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- 16 - - 17 - December 11, 2015, Room A
December 11, 2015, Room A
Plenary Session I
9:00-10:45
I-1
[P10-01]
9:00-9:15
Chairs: Mark Udey, Jonathan Barker, Shinichi Sato
Co-blockade of TIGIT and PD-1 signals in tumor-infiltrating cytotoxic T lymphocytes is an effective antimelanoma therapy
Takashi Inozume1, Tomonori Yaguchi2, Junpei Furuta1, Kazutoshi Harada3, Yutaka Kawakami2, Shinji Shimada1
1
Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Division of Cellular Signaling, Institute for Advanced
Medical Research, Keio University School of Medicine, 3Department of Dermatology, Tokyo Medical University
I-2
[P01-04]
9:15-9:30
Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD
8 epitope peptide
Naoko Okiyama1,2,3,4, Hisanori Hasegawa1, Takatoku Oida3, Shinya Hirata1, Hiroo Yokozeki2, Manabu Fujimoto4, Hitoshi Kohsaka1,3
1
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo,
Japan, 2Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo,
Japan, 3Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan, 4Department of Dermatology,
Faculty of Medicine, University of Tokyo, Ibaraki, Japan
I-3
[P04-03]
9:30-9:45
TLN-58, newly discovered hCAP18 processing form found in the lesion vesicle of palmoplantar pustulosis
I-4
[P01-03]
9:45-10:00
Anti-desmoglein 3 IgG production is reduced by intravenous immunoglobulin in B220- antibody-secreting cells in
mice with pemphigus vulgaris
Masamoto Murakami, Kana Masuda, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Mikiko Tohyama, Koji Sayama
Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan
Yuko Kase1,2, Jun Yamagami1, Naoko Wada1, Hayato Takahashi1, Shigeo Koyasu3,4, Masayuki Amagai1,3
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Central Research Laboratory, Japan Blood Products
Organization, 3RIKEN Center for Integrative Medical Sciences, 4Department of Microbiology and Immunology, Keio University School
of Medicine
I-5
[P04-02]
10:00-10:15
Expression ability of RNAIII encoding δ-toxin in S. aureus isolated from infant skin is associated with atopic
dermatitis development
Yuumi Nakamura1, Yuzaburo Inoue2, Yuki Katayama1,2, Gabriel Nunez3, Naoki Shimojo2, Hiroyuki Matsue1
1
Department of Dermatology, Chiba University, Chiba, Japan, 2Department of Pediatrics, Chiba University, Chiba, Japan, 3Pathology
and Comprehensive Cancer Center, University of Michigan, Michigan, USA
I-6
[P12-01]
10:15-10:30
Antiinflammatory role of Langerhans cells and apoptotic keratinocytes in UVB-induced cutaneous inflammation
I-7
[P08-01]
10:30-10:45
Inducible basal keratinocyte-specific knockout of the LamA3 gene: a model for wound healing and fibrosis?
Mayumi Hatakeyama, Atsushi Fukunaga, Ken Washio, Kumiko Taguchi, Chikako Nishigori
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan
Monique Aumailley1, Sabrina Koenig1, Takako Sasaki2, Monika Pesch1
1
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany, 2Department of Matrix Medicine, Faculty of
Medicine, Oita University, Oita, Japan
Concurrent Oral Session 1
(Epidermal Structure and Function)
10:50-12:14
C01-01
[P05-14]
10:50-11:02
Chairs: Masashi Akiyama, Mayumi Komine
Knockdown of either filaggrin or loricrin increases the productions of IL-1α, IL-8, IL-18 and GM-CSF in stratified
human keratinocytes
Takashi Sakai1, Ryo Nishiyori2, Yutaka Hatano1, Wei Zhang1, Sakuhei Fujiwara1
1
Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan, 2Medical student, Faculty of Medicine, Oita
University, Oita, Japan
C01-02
[P05-13]
11:02-11:14
Corneodesmosome degradation is disturbed in stratum corneum of atopic dermatitis lesional skin in spite of
kallikrein 7 over-expression
Satomi Igawa, Mari Kishibe, Takashi Shibuya, Nao Saito, Shin Iinuma, Masaru Honma, Akemi Ishida-Yamamoto
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
C01-03
[P05-11]
11:14-11:26
Wy14643, a PPARα agonist, down-regulates expressions of TARC and RANTES and up-regulates those of filaggrin
in cultured human keratinocytes
Wei Zhang, Takashi Sakai, Yutaka Hatano, Sakuhei Fujiwara
Department of Dermatology, Faculty of Medicine, Oita University
- 18 -
C01-04
[P05-12]
11:26-11:38
Increase of Prolactin-like protein expression by SIRT1 knockdown or cellular aging
C01-05
[P05-09]
11:38-11:50
A novel RIPK1 function in human epidermal inflammation and keratinization
C01-06
[P05-08]
11:50-12:02
TRAF6-dependent activation of keratinocytes triggers early immunological events in Th17 immune response
C01-07
[P05-07]
12:02-12:14
Discovery of a novel parathyroid hormone family member in skin that regulates keratinocyte differentiation
Kohei Horimoto1, Risa Kunimoto2, Risa Hashimoto2, Naohiro Ueda2, Yoshiyuki Horio2, Toshiharu Yamashita1
1
Department of Dermatology, Sapporo Medical University School of Medicine, 2Department of Pharmacology, Sapporo Medical
University School of Medicine
Nao Saito, Masaru Honma, Takashi Shibuya, Satomi Igawa, Mari Kishibe, Akemi Ishida-Yamamoto
Asahikawa Medical University, Hokkaido, Japan
Reiko Matsumoto, Teruki Dainichi, Kenji Sakurai, Takashi Nomura, Kenji Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Emi Sato1, Jun Muto2, Ling-juan Zhang1, Christopher Adase1, James A. Sanford1, Teruaki Nakatsuji1, Richard L. Gallo1
1
Department of Dermatology, University of California, San Diego, 2Department of Dermatology, Aichi medical University
Luncheon Seminar 1
"Cutaneous immunity"
12:25-13:15
LS1-1
Chair: Shinichi Sato
B cell pathobiology and B cell-targeted therapy: an update
Manabu Fujimoto
Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
LS1-2
New aspects of autoantibodies in collagen diseases
Minoru Hasegawa
Department of Dermatology, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Co-sponsored by Tokiwa Pharmaceutical Co., Ltd
The 16th Galderma Award Presentation Meeting and Ceremony
13:20-14:20
GAW1
Chairs: Shinichi Sato, Masayuki Amagai, Yoshiki Tokura
Chemoradiotherapy with taxane is superior to conventional surgery and radiotherapy in the management of
cutaneous angiosarcoma: a multicentre, retrospective study
Yasuhiro Fujisawa
Department of Dermatology, University of Tsukuba
GAW2
Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora’s Box: A Novel Genetic Pathogenesis
Yasushi Ogawa
Nagoya University Graduate School of Medicine, Department of Dermatology
GAW3
Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
Shinji Noda
Department of Dermatology, The University of Tokyo Graduate School of Medicine
GAW4
An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug
reactions
Nao Saito
Department of Dermatology, Asahikawa Medical University
Co-sponsored by GALDERMA K.K.
- 19 -
JSID Award Lecture
14:20-14:50
Chair and Presenter: Shinichi Sato
Tumor microenvironment in cutaneous T-cell lymphoma
Makoto Sugaya
Department of Dermatology, University of Tokyo Graduate School of Medicine
JSID Kisaragi Award
14:50-14:55
Presenter: Shinichi Sato
High expression of Mcl-1L via the MEK-ERK-phospho-STAT3 (Ser727) pathway protects melanocytes and
melanoma from UVB-induced apoptosis
Takeshi Fukumoto
Doctoral Program, Graduate School of Medicine, Kobe University
Award Ceremony
14:55-15:10
JSID’s Fellowship SHISEIDO Research Grant
Presenter: Shinji Inomata
The role of epidermal basement membrane on skin aging
Ken Natsuga
Department of Dermatology, Hokkaido University Graduate School of Medicine
The role of ex vivo induced regulatory B cells in oxidative stress with systemic sclerosis
Ayumi Yoshizaki
Department of Dermatology, The University of Tokyo Graduate School of Medicine
JSID Honorary Membership
Presenter: Shinichi Sato
Tanioku Kihei Memorial Lecture
15:10-15:40
Chair: Keiji Iwatsuki
T cells in Barrier Tissues: new insights
Thomas S. Kupper
Brigham and Women’s Hospital Department of Dermatology, Harvard Institutes of Medicine
(Autoimmunity Inflammation)
!
15:45-16:57
C04-01
[P01-25]
15:45-15:57
Chairs: Setsuya Aiba, Qianjin Lu, Michihiro Hide
Kinetic of two distinct diseases induced by topical treatment with imiquimod cream in mice: skin inflammation
and systemic autoimmunity
Sayo Kataoka, Mayuko Yamamoto, Kentaro Ohko, Reiko Kamijima, Chisa Matsuoka, Shigetoshi Sano
Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan
C04-02
[P01-23]
15:57-16:09
Characterization of the population like follicular helper T cells in the peripheral blood in patients with pemphigus
C04-03
[P01-24]
16:09-16:21
Interleukin-17A plays a fundamental role in the expression of psoriasis signature genes in keratinocytes through
the induction of IκB-ζ
Jun Yamagami, Aki Kamata, Masayuki Amagai
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
Ryuta Muromoto, Toru Hirao, Keisuke Tawa, Tadashi Matsuda
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
- 20 -
C04-04
[P01-21]
16:21-16:33
Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody
production and disease activity
Takashi Matsushita1, Yasuhito Hamaguchi1, Minoru Hasegawa2, Manabu Fujimoto3, Kazuhiko Takehara1
1
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,
2
Department of Dermatology, University of Fukui, 3Department of Dermatology, Faculty of Medicine, University of Tsukuba
C04-05
[P01-22]
16:33-16:45
CRH is a stimulator for mucosal-type mast cell degranulation and proliferation
C04-06
[P01-20]
16:45-16:57
Inflammatory skin march: a concept for IL-1 mediated skin inflammation to cardio-vascular events including
atopic dermatitis and psoriasis
Yukari Mizukami1, Koji Sugawara1, Ralf Paus2, Daisuke Tsuruta1
1
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, 2Centre for Dermatology, Institute of
Inflammation and Repair, University of Manchester, Manchester, UK
Keiichi Yamanaka, Hitoshi Mizutani
Department of Dermatology, Mie University, Mie, Japan
Sweets Seminar 1
"TCR BCR Repertoire Analysis and Array CGH for Health and Disease
・T B Cell Receptor Repertoire Analysis for ‘Deep Surveillance’ of Diseases
・Array Comparative Genomic Hybridization to Analyze Copy-Number
Alterations in Genomic DNA from Cutaneous Lymphoma"
!
!
17:10-17:55
SS1-1
Chairs: Minoru Takata, Toshihisa Hamada
!
Development and applications of next generation T cell receptor (TCR) B cell receptor (BCR) repertoire analysis
Takaji Matsutani
Repertoire Genesis, Inc., Osaka
SS1-2
"
Array Comparative Genomic Hybridization to Analyze Copy Number Alterations in Genomic DNA from
Cutaneous Lymphoma
Maarten H. Vermeer
Department of Dermatology, Leiden University, Leiden
!
Co-sponsored by Repertoire Genesis Incorporation Wako Pure Chemical Industries, Ltd.
One-minute presentation I
(Epidermal Structure and Function, Autoimmunity Inflammation, Immunology 1:
Adaptive Immunity)
!
18:00-19:00
O1-01
[P05-04]
Chair: Daisuke Sawamura
Sphingomyelin synthase knockout mice exhibit an ichthyotic phenotype with epidermal lipid abnormalities
Akihito Nishi1, Takeshi Ichikawa2, Shota Sakai3, Tadashi Yamashita1, Yoshihiro Tokudome2, Toshiro Okazaki4, Debra Crumrine5,
Yoshikazu Uchida5, Peter M. Elias5, Yoshio Hirabayashi6, Sumiko Hamanaka2,6
1
Laboratory of Biochemistry, Azabu University School of Veterinary Medicine, 2Laboratory of Dermatological Physiology, Faculty of
Pharmaceutical Sciences, Josai University, 3Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life
Science, Hokkaido University, 4Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical
University, 5Department of Dermatology, School of Medicine, University of California, San Francisco, 6Laboratory for Molecular
Membrane Neuroscience, Brain Science Institute, RIKEN
O1-02
[P05-10]
Alterations of Epidermal Functions in 3 beta-hydroxysteroid-delta 8, delta 7-isomerase deficient (ConradiHunermann) Mice
Mao-Qiang Man, Carolyn Cheung, Peter M. Elias
dermatology, VAMC and University of California San Francisco, CA, USA
O1-03
[P05-15]
Pituitary adenylate cyclase-activating polypeptide promotes eccrine sweat secretion
Shun Sasaki1, Jun Watanabe2, Hirokazu Ohtaki3, Seiji Shioda4, Hirohiko Sueki1
1
3
Department of Dermatology, Showa University School of Medicine, Tokyo, Japan, 2Center for Biotechnology, Showa University,
Department of Anatomy, Showa University School of Medicine, 4Hoshi University School of Pharmacy and Pharmaceutical Sciences
- 21 -
O1-04
[P05-16]
Physiological impacts of carbonylated proteins in the stratum corneum
Hitoshi Masaki1, Yumiko Yamawaki1, Yuki Sagawa1, Taeko Mizutani1, Yuri Okano1, Difei Chen2, Jinhua Li3
1
School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan, 2ROLMEX (Shanghai) Biotechnology
Research, 3Nature Beauté (Shanghai) Cosmetics
O1-05
[P05-17]
An immunohistochemical and ultrastructural study of familial type- and non-familial type- white sponge nevus
Toshio Demitsu1, Yoshinori Jinbu2, Aki Yamamoto2, Naoka Umemoto1, Kozo Yoneda3, Hidetoshi Tsuda4, Mamitaro Ohtsuki4,
Yoshiyuki Mori2, Mayumi Komine4
1
Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama City, Japan, 2Department of Dentistry, Oral
and Maxillofacial Surgery, Jichi Medical University School of Medicine, 3Department of Dermatology, Faculty of Medicine, Kagawa
University, 4Department of Dermatology, Jichi Medical University School of Medicine
O1-06
[P05-18]
N-glycosylation in desmoglein is required for desmosome assembly
Seon-Pil Jin1,2, Jang-Hee Oh2, Eun Young Seo2, Jin Ho Chung1,2
1
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea, 2Department of Dermatology, Seoul
National University College of Medicine, Seoul, Korea
O1-07
[P05-19]
Sandalwood oil downregulates skin inflammation through 11β-HSD1 activation in keratinocytes
Saori Itoi-Ochi, Sayaka Matsumura, Mika Terao, Hiroyuki Murota, Ichiro Katayama
Department of Dermatology, Osaka University Graduate School of Medicine
O1-08
[P05-20]
Non-Staining Imaging of Keratinocyte Differentiation with Stimulated Raman Scattering Microscopy
Shinya Iwanaga1, Mariko Egawa1, Kyoya Tokunaga2, Junichi Hosoi1, Yasuyuki Ozeki2
1
Shiseido Research Center, Yokohama, Japan, 2Department of Electrical Engineering and Information Systems, The University of
Tokyo, Tokyo, Japan
O1-09
[P05-21]
Intense pulsed light increases hyaluronan and CD44 in the epidermal keratinocytes and improves age-related
epidermal structure defects
Sang Eun Lee1, Hye Rang On1, Hee Jung Lee2
1
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea, 2Department of Dermatology, CHA Bundang
Medical Center, CHA University, Seongnam, Korea
O1-10
[P05-22]
Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis
Makiko Kido-Nakahara1, Khudishta M Aktar1, Masutaka Furue1,2, Takeshi Nakahara2
1
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Division of Skin Surface
Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
O1-11
[P05-23]
Regulatory roles of Syk in epidermal keratinocyte differentiation
Nan-Lin Wu1,2, Duen-Yi Huang3, Wan-Wan Lin3
1
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan, 2Department of Medicine, Mackay Medical College, New
Taipei City, Taiwan, 3Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
O1-12
[P05-32][SE]
Comprehensive analysis of long non-coding RNAs in keratinization
Toshifumi Nomura
O1-13
[P01-11]
Analysis of domain structure-function relationship in NOD-like receptor family members
Junichiro Hiruma1,2, Masashi Miyai1, Mami Yamamoto-Tanaka1,2, Ryoji Tsuboi2, Toshihiko Hibino1
1
O1-14
[P01-13]
Shiseido Research Center, Yokohama, Japan, 2Department of Dermatology, Tokyo Medical University, Tokyo, Japan
Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice
Noriko Ando1, Yuki Nakamura2, Rui Aoki1, Kayoko Ishimaru2, Shinji Shimada1, Atsuhito Nakao2
1
Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Immunology, University of Yamanashi,
Yamanashi, Japan
O1-15
[P01-14]
Bone marrow-derived clonal mesenchymal stem cells inhibit NK- and T-cell infiltration and reduce alopecia
areata in mouse model
Ji Won Byun1, Hyo Jin Kim1, Kwangmin Na2, Sun Uk Song2, Myung Shin Jeon2, Gwang Seong Choi1
1
The Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea, 2Translational Research Center,
Inha University School of Medicine, Incheon, Republic of Korea
O1-16
[P01-26]
Exosome expression in the skin and sera of systemic sclerosis patients, and its possible therapeutic application
against skin ulcer
Kayo Nakamura, Masatoshi Jinnin, Satoshi Fukushima, Hironobu Ihn
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
- 22 -
O1-17
[P01-27]
NOD2 inflammasome is up-regulated in the skin with atopic dermatitis.
Masashi Miyai1, Mami Yamamoto-Tanaka1,3, Mika Sawane1, Haruyo Yamanishi1, Masakiyo Sakaguchi2, Ryoji Tsuboi3,
Toshihiko Hibino1
1
Shiseido Research Center, Yokohama, 2Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry
and Pharmaceutical Sciences, Okayama, 3Department of Dermatology, Tokyo Medical University, Tokyo, Japan
O1-18
[P01-28]
Cathelicidin peptide LL-37 induces UVB-triggered inflammasome activation and angiogenesis: Possible
implications for rosacea
Yoji Hirai1, Sonja Kresse2, Suzanna Salzer2, Shin Morizane1, Keiji Iwatsuki1, Thomas Ruzicka2, Juergen Schauber2
1
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,
Japan, 2Department of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany
O1-19
[P01-29]
KLK6 is required for imiquimod-induced psoriasiform skin inflammation in mice
Shin Iinuma1, Mari Kishibe1, Nao Saito1, Satomi Igawa1, Masaru Honma1, Yoshio Bando2, Shigetaka Yoshida2,
Akemi Ishida-Yamamoto1
1
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan, 2Department of Functional Anatomy and
Neuroscience, Asahikawa Medical University, Asahikawa, Japan
O1-20
[P01-30]
Mechanism of S100A9 induction in the skin with atopic dermatitis―involvement of NOD2 inflammasome
activation―
Mami Yamamoto-Tanaka1,2, Masashi Miyai1, Mika Sawane1, Haruyo Yamanishi1, Masakiyo Sakaguchi3, Ryoji Tsuboi2,
Toshihiko Hibino1
1
Shiseido Research Center, Yokohama, Japan, 2Department of Dermatology, Tokyo Medical University, Tokyo, Japan, 3Department of
Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
O1-21
[P01-31]
IL-1 and IL-36 are the dominant cytokines in Palmar Plantar Pustulosis
Andrew Johnston1, Xianying Xing1, Liza Wolterink1, Drew H. Barnes1, J. Michelle Kahlenberg3, Paul W. Harms2,
Johann E. Gudjonsson1
1
Dermatology, University of MIchigan, Ann Arbor, MI, USA, 2Department of Pathology, University of MIchigan, Ann Arbor, Michigan,
USA, 3Department of Rheumatology, University of MIchigan, Ann Arbor, Michigan, USA
O1-22
[P01-32]
Platelets contribute to leukocyte recruitment to skin in allergic and irritant contact dermatitis
Risa Tamagawa-Mineoka, Risa Yasuike, Eri Hotta, Hiromi Mizutani, Naomi Nakamura, Norito Katoh
Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
O1-23
[P01-33]
!
Prostaglandin E receptor4 inhibition restores UVB-induced downregulation of ATP2A2 SERCA2 in cultures
normal human keratinocytes
Maya Kamijo1, Akino Wada1, Reiko Mineki2, Tamami Sakanishi3, Shigaku Ikeda1
1
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2Laboratory of Proteomics and
Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, 3Division of Cell Biology,
Research Support Center, Juntendo University Graduate School of Medicine
O1-24
[P01-34]
Subcutaneous presensitization to protease antigen and IL-33-dependent airway responses cooperatively
contribute to airway inflammation
Hirono Ochi1,2, Toshiro Takai2, Seiji Kamijo2, Sakiko Shimura2, Natsuko Maruyama1,2, Akira Matsuda3, Hirohisa Saito2,4,
Susumu Nakae2,5, Ko Okumura2, Hideoki Ogawa1,2, Shigaku Ikeda1,2
1
Department of Allergology and Dermatology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Atopy (Allergy)
Research Center, Juntendo University Graduate School of Medicine, 3Department of Ophthalmology, Juntendo University Graduate
School of Medicine, 4Department of Allergy and Immunology, National Research Institute for Child Health and Development, 5The
Institute of Medical Science, The University of Tokyo
O1-25
[P01-35]
Analysis of the ROS production in neutrophils of Nakajo-Nishimura syndrome patients
Kayo Kunimoto1, Fumiko Ozaki2, Fukumi Furukawa1, Nobuo Kanazawa1
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Center for iPS Cell research and Application, Kyoto
University
O1-26
[P01-36]
Serum levels of various anti-Fcγ receptor antibodies in patients with systemic sclerosis
Takafumi Kadono1, Manabu Tomita2, Yoshihide Asano2, Shinichi Sato2
1
Department of Dermatology, St. Marianna University, School of Medicine, Kawasaki, Japan, 2Department of Dermatology, The
University of Tokyo, Tokyo, Japan
O1-27
[P01-37]
Increased Expression of CXCR3 and its Ligands in Vitiligo Patients and its Role as Potential Clinical Markers for
Vitiligo
Xiuxiu Wang, Leihong Xiang
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China
- 23 -
O1-28
[P01-38]
Electrophysiological characterization of BNP- and GRP-responsive dorsal horn neurons in spinal itch
transmission
Mitsutoshi Tominaga1, Fumiya Kusube1,2, Hiroaki Kawasaki1, Fumiyuki Yamakura3, Hisashi Naito4, Hideoki Ogawa1,
Yasuhiro Tomooka2, Kenji Takamori1,5
1
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2Department of
Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 3Juntendo University
Faculty of International Liberal Arts, 4Institute of Health and Sports Science & Medicine, Juntendo University, 5Department of
Dermatology, Juntendo University Urayasu Hospital
O1-29
[P01-39]
Glycyrrhizin ameliorates fibrosis, vasculopathy, and immune abnormalities in animal models of systemic sclerosis
Takashi Yamashita1, Yoshihide Asano1, Takashi Taniguchi1, Ryosuke Saigusa1, Kouki Nakamura1, Shunsuke Miura1,
Tetsuo Toyama1, Takehiro Takahashi1, Yohei Ichimura1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
O1-30
[P01-40]
University of Tokyo Graduate School of Medicine, 2Arthritis Center, Boston University School of Medicine
Keratin1, keratin10, desmoglein1 and desmocollin1 expressions are downregulated in the lesional epidermal
keratinocytes of atopic dermatitis
Ami Totsuka1, Miyuki Omori-Miyake2, Yuichiro Tsunemi1, Junji Yagi2, Makoto Kawashima1
1
Department of Dermatology, Tokyo Women’s Medical University, Tokyo, Japan, 2Department of Microbiology and Immunology,
Tokyo Women’s Medical University, Tokyo, Japan
O1-31
[P01-41]
Key immune modulatory effects exerted by combination of calcipotriol and corticosteroid on psoriasis
inflammation
Paola Lovato1, Hanne Norsgaard1, Mads Røpke2
1
O1-32
[P01-42]
Skin Research, LEO Pharma, Denmark, 2Clinical Pharmacology, LEO Pharma, Denmark
Glycolic acid silences inflammasome complex genes by inducing DNA methylation in HaCaT cells
Jen-Hung Yang1, Sheau-Chung Tang1,2, Jih-I Yeh1,3, Sung-Jen Hung1, Yu-Ping Hsiao4, Fu-Tong Liu2,5
1
1. Department of Dermatology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 2. Department of Biochemistry, Tzu Chi
University; 3. Institute of Medicine, Tzu Chi University, Hualien, Taiwan, 2Institute of Biomedical Sciences, Academia Sinica, Taipei,
Taiwan, 3Department of Family Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, 4Department of Dermatology, Chung
Shan Medical University Hospital, Taichung, Taiwan, 5Department of Dermatology, University of California Davis School of
Medicine, Sacramento, California, USA
O1-33
[P01-43]
Increase of psoriasis-associated IL-8 in the intralesional blood despite undetectable in the peripheral blood
Tatsushi Ishimoto, Saho Kataoka, Takeo Shiga, Shigetoshi Sano
O1-34
[P01-44]
Decreased expression of ELOVL and ceramide synthase in dermatitis caused by repeated exposure to house-dust
mite in NC Nga mice
!
Hiroyuki Kanoh1, Asako Ishitsuka1, Etsuko Fujine1, Shuhei Matsuhaba2, Mitsuhiro Nakamura3, Naoki Inagaki2, Yoshiko Banno1,
Mariko Seishima1
1
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 2Laboratory of Pharmacology, Gifu
Pharmaceutical University, Gifu, Japan, 3Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan
O1-35
[P01-45]
Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis
Kanako Matsuyama1, Yoko Mizutani1, En Shu1, Hiroyuki Kanoh1, Tatsuhiko Miyazaki2, Mariko Seishima1
1
The department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 2the division of Pathology, Gifu
University Hospital
O1-36
[P01-46]
Autoantibody profile and clinical manifestations related to anti-synthetase syndrome
Hiroko Fukamatsu1, Yoji Hirai1, Tomoko Miyake1, Tatsuya Kaji1, Toshihisa Hamada1, Seiichiro Norikane2, Keiji Iwatsuki1
1
O1-37
[P01-47]
Department of Dermatology, Okayama University Hospital, 2Department of Radiology, Okayama University Hospital
Usefulness of flow cytometric analysis for detection of anti-FcεRIα autoantibody in chronic spontaneous urticaria
Satoshi Izaki1,2, Satoshi Nunomura1,2, Koremasa Hayama1,2, Daisuke Fujisawa1,2, Yuko Hatada1,2, Hideki Fujita1, Chisei Ra2,
Yoshimichi Okayama2, Tadashi Terui1
1
Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan, 2Allergy and
Immunology Group, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan
O1-38
[P01-48]
Increased levels of high mobility group box-1 in the serum and skin in patients with generalized pustular psoriasis
Tomoya Watanabe, Yukie Yamaguchi, Noriko Komitsu, Naoko Takamura, Yuko Watanabe, Michiko Aihara
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
O1-39
[P01-49]
Association of urinary biopyrrin with disease activity of atopic dermatitis in adults
Sayaka Shibama1,2, Tsukasa Ugajin1, Tokio Yamaguchi3, Hiroo Yokozeki1
1
Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 2Department of Dermatology, Sakura Hospital,
Medical Center, Toho University, 3Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental
University
- 24 -
O1-40
[P01-50]
Gnaphalium affine D. Don inhibits the inflammatory response by suppressing the MAPK-mediated transcriptional
activation in RAW264.7 cells.
Kyung-Baeg Roh1, Jung-A Lee1, Junho Park2, Kwangseon Jung2, Eunsun Jung1, Deokhoon Park1
1
O1-41
[P01-51]
Elevated serum YKL-40 in patients with Behcet’s disease
Do-Young Kim1,2, Yuri Ahn1, Zhenlong Zheng1, Dae Suk Kim1, Min Ju Choi1, Dongsik Bang2
1
2
O1-42
[P01-52]
Biospectrum Life Science Institute, seongnam, Korea, 2SkinCure Inc., seongnam, Korea
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea,
Department of Dermatology, Catholic Kwandong University, International St. Mary´s Hospital, Incheon, Korea
The evaluation of B10 cells in the patients with autoimmune blistering diseases
Miho Kabuto, Noriki Fujimoto, Toshifumi Takahashi, Toshihiro Tanaka
Department of Dermatology, Shiga University of Medical Science, Shiga, Japan
O1-43
[P01-53]
Expression of phosphatidylglucoside in human skin disorders atopic dermatitis and psoriasis
Roudy C. Ekyalongo1, Noriko Yokoyama1, Katsunari Kina1, Hitoshi Nakayama1, Mitsuaki Tominaga1, Hideoki Ogawa1,
Kenji Takamori1,2, Yasushi Suga2, Yoshio Hirabayashi1,3, Kazuhisa Iwabuchi1,4
1
Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, 2Department of
Dermatology, Juntendo University Urayasu Hospital, 3Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science
Institute, 4Infection Control Nursing, Juntendo University Graduate School of Health Care and Nursing
O1-44
[P01-54]
A possible example of an inverse intramolecular epitope-spreading phenomenon in bullous pemphigoid
associated with psoriasis
Naoki Oiso1, Kazunori Okahashi1, Norito Ishii2, Shusuke Uchida1, Hiromasa Matsuda1, Takashi Hashimoto2, Akira Kawada1
1
Department of Dermatology, Kinki University Faculty of Medicine, 2Department of Dermatology, Kurume University School of
Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
O1-45
[P10-06]
Filaggrin gene mutations are significantly associated with food allergy in Japanese primary school children
Michihiro Kono1, Masashi Akiyama1, Toshifumi Nomura2, W. H. Irwin McLean3, Hiroshi Shimizu2, Kazumitsu Sugiura1,
Akira Hata4, Yoshitaka Okamoto5, Yuzaburo Inoue6, Yoichi Suzuki4,7, Naoki Shimojo6
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Dermatology,
Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Centre for Dermatology and Genetic Medicine, College of Life
Sciences and College of Medicine, Dentistry & Nursing, University of Dundee, Dundee, UK, 4Department of Public Health, Graduate
School of Medicine, Chiba University, Chiba, Japan, 5Department of Otolaryngology, Head and Neck Surgery, Graduate School of
Medicine, Chiba University, Chiba, Japan, 6Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan,
7
Department of Education and Training, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
O1-46
[P10-07]
Distinctive downmodulation of plasmacytoid dendritic cell functions by vitamin D3 analogue
Takahiro Suzuki, Kazuki Tatsuno, Taisuke Ito, Yoshiki Tokura
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
O1-47
[P10-08]
TSLP and IL-4 interact to promote mutual receptor expression on CD4+ T cells in atopic dermatitis
Kazuki Tatsuno, Toshiharu Fujiyama, Hayato Yamaguchi, Yoshiki Tokura
Department of Dermatology, Hamamatsu University School of Medicine
O1-48
[P10-09]
Increased serum soluble DNAM-1 levels and decreased membrane DNAM-1 expression on NK cells and CD8
+ cells in cutaneous T-cell lymphoma
Naomi Takahashi, Makoto Sugaya, Hiraku Suga, Tomonori Oka, Tomomitsu Miyagaki, Shinichi Sato
Department of Dermatology, University of Tokyo, Tokyo, Japan
O1-49
[P10-10]
Tumor-associated macrophages and stromal factors play roles at different stages in developing mycosis fungoides
Taku Fujimura, Sadanori Furudate, Aya Kakizaki, Yumi Kambayashi, Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine
O1-50
[P10-11]
Heparinoid blocks the triggering of keratinocyte-mediated inflammation by inhibiting ERK pathway
Ryo Utsunomiya1, Hidenori Okazaki2, Xiuju Dai1, Masamoto Murakami1, Ken Shiraishi1, Mikiko Tohyama1, Koji Sayama1
1
The Department of Dermatology, University of Ehime, Ehime, Japan, 2The Department of Dermatology, Ehime Prefectural Central
Hospital, Ehime, Japan
O1-51
[P10-12]
Murine models of epicutaneous sensitization to protease allergen, which leads to airway eosinophilia upon
subsequent airway challenge
Sakio Shimura1, Toshiro Takai2, Hideo Iida1, Seiji Kamijo2, Hirono Ochi1,2, Natsuko Maruyama2, Izumi Nishioka1,2,
Punyada Suchiva1,2, Akira Matsuda3, Hirohisa Saito1,4, Susumu Nakae1,5, Hideoki Ogawa1,2, Ko Okumura1, Shigaku Ikeda1,2
1
Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Department of Ophthalmology, Juntendo
University Graduate School of Medicine, Tokyo, Japan, 4Department of Allergy and Immunology, National Research Institute for
Child Health and Development, 5The Institute of Medical Science, The University of Tokyo
- 25 -
O1-52
[P10-13][SE]
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses
Tetsuya Honda1, Yu Sawada1,2, Yuichi Kobayashi3, Motonobu Nakamura2, Yoshiki Miyachi1, Kenji Kabashima1,4
1
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Dermatology, University
of Occupational and Environmental Health, Kitakyushu, Japan, 3Department of Biomolecular Engineering, Graduate School of
Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan, 4PRESTO, Japan Science and Technology Agency,
Tokyo, Japan
Award Ceremony
19:00-19:20
!
SID JSID Young Fellow Collegiality Awards
Presenter: Mark Udey
Anna DiNardo, University of California
!
ESDR JSID Young Fellow Collegiality Awards
Presenter: Jonathan Barker
Joanna Jackow, Institut Imagine
!
ASDR JSID Exchange Program
Presenter: Nikolas Haass
Miko Yamada, The University of Queensland
- 26 -
December 11, 2015, Room B
(Human Clinical Research and Therapeutics)
10:50-12:14
Chairs: Takuro Kanekura, Maarten H. Vermeer, Manabu Fujimoto
C02-01
[P04-17]
10:50-11:02
Molecular imaging based skin cancer diagnostic platform
C02-02
[P04-16]
11:02-11:14
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis
C02-03
[P04-15]
11:14-11:26
The presence of anti-phosphatidylserine-prothrombin complex antibodies in patients and model rats with
rheumatoid vasculitis
Miko Yamada1, Dennis Miller2, Julia Parrish-Novak2, Lynda Spelman3, Tarl Prow1
1
Dermatology Research Centre, University of Queensland, School of Medicine, Translational Research Institute, 2Blaze Bioscience,
Inc Seattle, WA, USA, 3Veracity Clinical Research, Brisbane, Australia
Masaru Honma, Shin Iinuma, Kyoko Kanno, Shigetsuna Komatsu, Masako Minami-Hori, Hajime Iizuka, Akemi Ishida-Yamamoto
Department of Dermatology, Asahikwa Medical University, Asahikawa, Japan
Tamihiro Kawakami1, Sora Takeuchi1, Yoshinao Soma1, Akihiro Ishizu2
1
Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan, 2Faculty of Health Sciences, Hokkaido
University, Sapporo, Japan
C02-04
[P04-13]
11:26-11:38
!
Clinicopathological insights into the phenotypic variation of autosomal recessive hypotrichosis wooly hair by
c.736T>A LIPH mutation
Misaki Ise1,2, Akiharu Kubo2, Takashi Sasaki3, Noriko Umegaki-Arao2, Masayuki Amagai2, Manabu Ohyama1,3
1
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan, 2Department of Dermatology, Keio University
School of Medicine, Tokyo, Japan, 3KOSE Endowed Program for Skin Care and Allergy Prevention, Keio University School of
Medicine, Tokyo, Japan
C02-05
[P04-14]
11:38-11:50
!
Preferential suppression of Th17 infiltrate in psoriasis plaque by topical calcipotriol corticosteroid combination:
T cell propagation study
Toshiharu Fujiyama1, Kazuki Tatsuno1, Hayato Yamaguchi1, Hideo Hashizume1,2, Taisuke Ito1, Yoshiki Tokura1
1
C02-06
[P04-11]
11:50-12:02
Hamamatsu University School of Medicine, 2Shimada city municipal hospital
A polarizing light microscopy can be an easy and reliable diagnostic tool of congenital keratinizing disorders
including Netherton syndrome
Daisuke Utsumi1, Hiroshi Uezato1, Hiroo Amano2, Yasushi Suga3, Kenzo Takahashi1
1
Department of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan, 2Department of
Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, 3Department of Dermatology, Juntendo University
Urayasu Hospital, Urayasu, Japan
C02-07
[P04-10]
12:02-12:14
High-incidence of Kaposi’s sarcoma in Miyako Island can be contributed by both high prevalence of HHV8 and
male specific susceptibility gene
Ryoko Awazawa1, Harutaka Katano2, Daisuke Utsumi1, Kentaro Hayashi1, Hiroshi Uezato1, Kenzo Takahashi1
1
Department of Dermatology, University of the Ryukyus, Okinawa, Japan, 2Department of Pathology, National Institute of Infectious
Disease, Tokyo, Japan
Luncheon Seminar 2
12:25-13:15
LS2-1
Chair: Shinji Shimada
Anti cancer immunity elicited by type 2 diabetes drug, metformin, is mediated by reversion of exhausted CD8T
cells within tumor tissues.
Heiichiro Udono
Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
LS2-2
New Insights of Tumor Immunology
Atsushi Otsuka
Department of Dermatology, Kyoto University Graduate School of Medicine
!
Co-sponsored by Bristol-Myers Squibb ONO PHARMACEUTICAL CO., LTD.
- 27 -
(Genetic Disease Gene Regulation and Gene Therapy)
!
15:45-16:57
C05-01
[P07-09]
15:45-15:57
Chairs: Yoshihide Asano, Akemi Yamamoto
Hyperpigmentation over the metacarpophalangeal joints as an initial cutaneous finding of hyaline fibromatosis
syndrome with ANTXR2 mutations
Kazumitsu Sugiura1, Atsuko Ohno2, Michihiro Kono1, Hiroshi Kitoh3, Kazuya Itomi2, Masashi Akiyama1
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Neurology, Aichi
Children’s Health and Medical Center, 3Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine,
Nagoya, Japan
C05-02
[P07-06]
15:57-16:09
A single laminin subunit deficiency alters other laminin expression depending on the mutated genes
Ken Natsuga1, Wataru Nishie1, Satoru Shinkuma1, Hideki Nakamura1, Mika Watanabe1, Naotomo Kambe2, Atsushi Hatamochi3,
Utako Kimura4, Yasushi Suga4, Hiroshi Shimizu1
1
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Dermatology,
Chiba University Graduate School of Medicine, Chiba, Japan, 3Department of Dermatology, Dokkyo Medical University School of
Medicine, Mibu, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan
C05-03
[P07-05]
16:09-16:21
Autoimmune Vitiligo is Associated with a Transcriptional Regulator that Affects Expression of HLA-A＊02: 01 In
Vivo
Masahiro Hayashi1,2, Ying Jin1,3, Daniel Yorgov4, Stephanie A Santorico1,4, James Hagman5,6, Richard A Spritz1,3
1
Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, USA, 2Department of
Dermatology, Yamagata University School of Medicine, Yamagata, Japan, 3Department of Pediatrics, University of Colorado School
of Medicine, Aurora, USA, 4Department of Mathematical & Statistical Science, University of Colorado Denver, Denver, USA,
5
Department of Biomedical Research, National Jewish Health, Denver, USA, 6Department of Immunology and Microbiology,
University of Colorado School of Medicine, Aurora, USA
C05-04
[P07-03]
16:21-16:33
Disruptive effect of mutated polycystin-1 on keratin 17 polymerisation in polycystic kidney disease with
steatocystoma multiplex
Kozo Yoneda1, Kozo Nakai1, Toshio Demitsu2, Yasuo Kubota1
1
Department of Dermatology, Faculty of Medicine, Kagawa University, 2Department of Dermatology, Jichi Medical University,
Saitama Medical Center
C05-05
[P07-04]
16:33-16:45
Mitotic recombination causes frequent somatic reversion of a dominant KRT1 mutation in ichthyosis hystrix
Curth-Macklin
Shotaro Suzuki1, Toshifumi Nomura1, Toshinari Miyauchi1, Hideki Nakamura1, Masashi Akiyama2, Hiroshi Shimizu1
1
Nagoya University Graduate School of Medicine, Nagoya, Japan
C05-06
[P07-02]
16:45-16:57
Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family
Takuya Takeichi1,2, Arti Nanda3, Masashi Akiyama2, Hejab Al-Ajmi3, John_A. McGrath1
1
St Johns Institute of Dermatology, Kings College London, Guys Hospital, London, UK, 2Department of Dermatology, Nagoya
University Graduate School of Medicine, Nagoya, Japan, 3Asad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait
Sweets Seminar 2
"New Concept of Psoriasis"
17:10-17:55
SS2-1
Chairs: Shigetoshi Sano, Yukari Okubo
Association between metabolic syndrome and bone markers in psoriatic arthritis
Hideki Nakajima
Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan
SS2-2
Psoriasis: an inflammatory disease with the orchestrated activation of cytokines
Akihiko Asahina
Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
Co-sponsored by Mitsubishi Tanabe Pharma Corporation
- 28 -
One-minute presentation II
(Human Clinical Research and Therapeutics, Genetic Disease Gene Regulation
and Gene Therapy, Hair and Cutaneous Development, Immunology 2: Innate
Immunity and Microbiology, Pigmentation and Melanoma)
!
18:00-19:00
O2-01
[P04-07]
Chair: Fukumi Furukawa
Diminishing sweating in patients with tuberous sclerosis and the relationship to mTOR signaling pathway
Fei Yang, Mari Wataya-Kaneda, Lingli Yang, Ichiro Katayama
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
O2-02
[P04-12]
VZV skin-test reaction, but not antibody, is an important predictive factor for postherpetic neuralgia
Kyoko Imoto1, Aiko Okazaki1, Fumitake Onishi2, Yoshiyuki Miyazaki2, Masayuki Okeda2, Shuichiro Yano2, Yukiko Takao2,4,
Yasuyuki Gomi2, Toyokazu Ishikawa2, Yoshinobu Okuno2, Yasuko Mori3, Hiroyasu Iso4, Koichi Yamanishi2,5, Hideo Asada1
1
Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan, 2The Research Foundation for Microbial
Diseases of Osaka University, Kagawa, Japan, 3Division of Clinical Virology, Department of Microbiology and Infectious Diseases,
Kobe University Graduate School of Medicine, Kobe, Japan, 4Public Health, Department of Social and Environmental Medicine,
Osaka University, Graduate School of Medicine, Osaka, Japan, 5National Institute of Biomedical Innovation, Ibaraki, Japan
O2-03
[P04-18]
Analyzing the content of metabolites in sweat derived from subjects with atopic dermatitis by use of nuclear
magnetic resonance
Emi Ono1, Hiroyuki Murota1, Yuki Mori2, Yoshichika Yoshioka2, Ichiro Katayama1
1
O2-04
[P04-19]
Department of Dermatology, Osaka University, Osaka, Japan, 2Institute for protein research Osaka University
Characterization of the centrosome cycle in normal human epidermis, Bowen’s disease and squamous cell
carcinoma
Saori Watanuki1, Toru Atsugi2, Takashige Hirano3, Keiji Tanese4, Keisuke Kouyama5, Masayuki Amagai4, Akiharu Kubo4
1
Department of Dermatology, National Center for Child Health and Development, Tokyo, Japan, 2KOSÉ Corporation, Tokyo, Japan,
Maruho Corporation, Kyoto, Japan, 4Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 5Center for
Clinical Research, Keio University School of Medicine, Tokyo, Japan
3
O2-05
[P04-20]
Serum interleukin-6 levels in response to biologic treatment in patients with psoriasis
Shinnosuke Muramatsu, Ryoji Kubo, Emi Nishida, Yoichi Shintani, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
O2-06
[P04-21]
Secukinumab, a Novel Anti-IL-17A Antibody, Exhibits Low Immunogenicity in Clinical Trials and Human in vitro
Assays
Frank Kolbinger1, Andrew Blauvelt2, April Armstrong3, Todd Fox4, Jiaqing Huang5, Eric Liang6, Annette Karle1,
Sebastian Spindeldreher1, Gerard Bruin1, Kristian Reich7
1
Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Oregon Medical Research Center, Portland, Oregon, USA,
Department of Dermatology, Colorado Health Outcomes Program, University of Colorado, School of Medicine, Aurora, Colorado,
USA, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharmaceuticals, East Hanover, New Jersey, USA, 6China Novartis Institutes
for BioMedical Research Co., Ltd, Shanghai, China, 7Dermatologikum Hamburg and Georg-August-University Göttingen, Hamburg,
Germany
3
O2-07
[P04-22]
The impact of antiviral therapy on renal function in herpes zoster patients: A multiple linear regression analysis
of 211 cases
Akira Kasuya1, Hayato Yamaguchi1, Masahiro Aoshima1, Kazuki Tatsuno1, Shigeki Ikeya1, Takahiro Suzuki1, Tetsuya Kawamura2,
Toshiharu Fujiyama1, Taisuke Ito1, Yoshiki Tokura1
1
O2-08
[P04-23]
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan, 2Hamamatsu Higashi Hospital
Increased CCL22 expression levels in psoriatic skin predict the good response to infliximab.
Ikko Kajihara, Syuhei Kusumoto, Saori Yamada, Katsunari Makino, Asako Ichihara, Takamitsu Makino, Satoshi Fukushima,
Masatoshi Jinnin, Hironobu Ihn
O2-09
[P04-24]
Relationship between incidence of secondary failure and antibody formation to infliximab in Japanese psoriasis
patients
Emi Nishida, Shinnosuke Muramatsu, Ryoji Kubo, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University of Medical Sciences, Nagoya, Japan
O2-10
[P04-25]
The comparison of the microRNAs profiles as the diagnostic tool between the cutaneous type adult T-cell
lymphoma and mycosis fungoides.
Sayaka Yamaguchi, Takuya Miyagi, Yu-ichi Yamamoto, Hiroshi Uezato, Kenzo Takahashi
Department of Dermatology, University of the Ryukyus, Japan
- 29 -
O2-11
[P04-26]
Ten cases of antihistamine-resistant Dermographic Urticaria treated with oral cyclosporine
Keiko Hanaoka, Makiko Hiragun, Akio Tanaka, Mikio Kawai, Michihiro Hide
Department of Dermatology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan
O2-12
[P04-27]
Factors that affect the duration of antibody treatment for cellulitis
Makoto Inaoki, Chihiro Nishijima
Department of Dermatology, National Hospital Organization Kanazawa Medical Center
O2-13
[P04-28]
New approach of Gold nanoparticles for treating skin disease
Tarl Prow1, Nhung Dang1, Kaitlin Nufer1, Liz Payne1, H.Peter Soyer1, Matthew Foote2
1
Dermatology Research Centre, University of Queensland, School of Medicine, Translational Research Institute, 2Department of
Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia
O2-14
[P07-07]
Abnormal locomotion in the XPA-deficient cell
Seiji Takeuchi1, Makoto Sato2, Chikako Nishigori1
1
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 2Department of Anatomy
and Neuroscience, Graduate School of Medicine, Osaka University
O2-15
[P07-08]
Identification of an Palindromic Motif in the Upstream Region of ABCA12 required for Promoter Activity in
Cultured Human Keratinocytes
Yoshitaka Shimizu1, Yasushi Ogawa1, Kazumitsu Sugiura1, Jun-ichi Takeda2, Kaori Sakai-Sawada3, Teruki Yanagi3, Atsushi Kon4,
Daisuke Sawamura5, Hiroshi Shimizu3, Masashi Akiyama1
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Division of Neurogenetics, Nagoya
University Graduate School of Medicine, Nagoya, Japan, 3Department of Dermatology, Hokkaido University Graduate School of
Medicine, Sapporo, Japan, 4Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan, 5Department of
Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
O2-16
[P07-10]
New insights into the pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation
Sei-ichiro Motegi1, Yoko Yokoyama1, Sachiko Ogino1, Kazuya Yamada1, Akihiko Uchiyama1, Buddhini Perera1, Yuko Takeuchi1,
Hiroshi Ohnishi2, Osamu Ishikawa1
1
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan, 2Department of Laboratory
Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan
O2-17
[P07-11]
Generalized verrucosis caused by a GATA2 deficiency
Mai Hattori1, Akira Shimizu1, Hiroo Amano1, Osamu Ishikawa1, Takeki Mitsui2, Kyoichi Kaira3, Daisuke Oikawa4,
Fuminori Tokunaga4, Hajime Nakano5, Daisuke Sawamura5
1
Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, 2Department of Hematology, Gunma
University Graduate School of Medicine, Gunma, Japan, 3Department of Oncology Clinical Development, Gunma University
Graduate School of Medicine, Gunma, Japan, 4Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation,
Gunma University, Gunma, Japan, 5Department of Dermatology, Hirosaki University Graduate School of Medicine, Aomori, Japan
O2-18
[P07-12]
Analysis of wound healing-related chemokines in the sera of epidermolysis bullosa patients.
Inkin Ujiie, Yasuyuki Fujita, Wakana Matsumura, Shotaro Suzuki, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe,
Hiroshi Shimizu
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
O2-19
[P07-13]
Genetic testing in cases of nevoid basal cell carcinoma syndrome using next-generation sequencing
Yoshihiro Matsudate1, Yoshiaki Kubo1, Issei Imoto2
1
Department of Dermatology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan,
2
Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
O2-20
[P07-14]
Downregulation of long thymic stromal lymphopoietin (TSLP) variant using antisense oligonucleotide
Zacharias A.D. Pramono1, Glenda G.K. Oh1, Dave K.B. Wee2, Mark B.Y. Tang1
1
Research Division, National Skin Centre, Singapore, 2Institute of High Performance Computing (IHPC, A＊STAR), 1 Fusionopolis
Way, #16-16 Connexis North, Singapore
O2-21
[P07-15]
COL5A1 gene mutation in three cases of classic type Ehlers-Danlos syndrome
Tatsushi Kiyohara1, Yumi Okubo1, Michiya Yamaguchi2, Mariko Yozaki1, Fumi Usui1, Masahiko Muto2, Sakuhei Fujiwara3,
Atsushi Utani1
1
Department of Dermatology, Nagasaki University Graduate School of Biochemical Science, 2Department of Dermatology,
Yamaguchi University Graduate School of Medicine, 3Department of Dermatology, Oita University
O2-22
[P07-16]
Mutation analysis of the IL36RN gene in Japanese patients with palmoplantar pustulosis
Toshifumi Takahashi, Noriki Fujimoto, Miho Kabuto, Takeshi Kato, Norikazu Fujii, Takeshi Nakanishi, Toshihiro Tanaka
Department of dermatology, Shiga university of medical science, Shiga, Japan
- 30 -
O2-23
[P07-17]
A case of xeroderma pigmentosum complementation group C with dyschromatosis on the covered area of the
skin
Taro Masaki1, Eiji Nakano1, Chikako Nishigori1, Tamio Suzuki2
1
Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe,
Japan, 2Department of Dermatology, Yamagata University Faculty of Medicine, Japan
O2-24
[P09-04]
Roles of two sphingomyelin synthase isoforms in murine hair
Takeshi Ichikawa1, Akihito Nishi2, Shota Sakai3, Asami Makino4, Yoshihiro Tokudome1, Tadashi Yamashita2, Toshiro Okazaki5,
Yoshikazu Uchida6, Tetsuya Tsuchida7, Yoshio Hirabayashi8, Sumiko Hamanaka1,7,8
1
Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, 2Laboratory of Biochemistry, Azabu
University School of Veterinary Medicine, 3Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life
Science, Hokkaido University, 4Lipid Biology Laboratory, Advanced Science Institute, RIKEN, 5Division of Hematology and
Immunology, Department of Internal Medicine, Kanazawa Medical University, 6Department of Dermatology, School of Medicine,
University of California, San Francisco, 7Department of Dermatology, Faculty of Medicine, Saitama Medical University, 8Laboratory
for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN
O2-25
[P09-06]
Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma
Gaku Tsuji1,2, Takamichi Ito1, Takeshi Nakahara1,3, Chikage Mitoma1,2, Akiko Hachiya2, Masaki Takemura2, Makiko Nakahara2,
Masutaka Furue1,2, Hiroshi Uchi2
1
Research and Clinical Center for Yusho and Dioxin, Kyushu University, Fukuoka, Japan, 2Department of Dermatology, Kyushu
University, Fukuoka, Japan, 3Division of Skin Surface Sensing, Kyushu University, Fukuoka, Japan
O2-26
[P09-07]
FGF18 Signaling Determines Radioresistance of Telogen Hair Follicles by the Arrest of Hair Cycling
Fumiaki Nakayama1, Sachiko Umeda1, Takashi Yasuda2, Mitsuko Kawano1, Mayumi Fujita1, Atsuko Ishikawa1, Toru Imamura1,3,4,
Takashi Imai1
1
Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological
Sciences (NIRS), Chiba, Japan, 2Radiation Emergency Medicine Research Program, Research Center for Radiation Emergency
Medicine, National Institute of Radiological Sciences (NIRS), Chiba, Japan, 3Biotechnology Research Institute for Drug Discovery,
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 4School of Bioscience and Biotechnology,
Tokyo University of Technology, Hachioji, Japan
O2-27
[P09-08]
FGF18 Maintains Hair Follicle Stem Cells after Radiation Exposure
Mitsuko Kawano1, Sachiko Umeda1, Takashi Yasuda2, Toru Imamura1,3,4, Takashi Imai1, Fumiaki Nakayama1
1
Sciences (NIRS), 2Radiation Emergency Medicine Research Program, Research Center for Radiation Emergency Medicine, National
Institute of Radiological Sciences (NIRS), 3Biotechnology Research Institute for Drug Discovery, National Institute of Advanced
Industrial Science and Technology (AIST), 4School of Bioscience and Biotechnology, Tokyo University of Technology
O2-28
[P11-08]
An unfavorable shift from Treg to Th17 development can be preventable by selective depletion of IL-6producting proinflammatory monocytes
Ryo Takahashi1, Yukiko Ushigome2, Tetsuo Shiohara1,2
1
Division of Flowcytometry, Kyorin University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology, Kyorin
University School of Medicine, Tokyo, Japan
O2-29
[P11-09]
!
!
Angiogenic peptide (AG) -30 5C activates human keratinocytes to produce cytokines chemokines, migrate and
proliferate via MrgX receptors
Chanisa Kiatsurayanon1,2, François Niyonsaba1, Shigaku Ikeda1,2, Ko Okumura1, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology,
Juntendo University Graduate School of Medicine, Tokyo, Japan
O2-30
[P11-10]
IL-33 promotes ICAM-1 expression via NF-kB in murine mast cells
Takafumi Numata, Tomonobu Ito, Tatsuo Maeda, Chizu Egusa, Ryoji Tsuboi
Department of Dermatology, Tokyo Medical University
O2-31
[P11-11]
Stem Cell Factor inhibited MHC class II expression in IL-33-treated mast cells
Tomonobu Ito1, Chizu Egusa1, Tatsuo Maeda1, Takafumi Numata1, Nobuhiro Nakano2, Chiharu Nishiyama3, Ryoji Tsuboi1
1
3
O2-32
[P11-12]
Department of Dermatology, Tokyo Medical University, 2Atopy (Allergy) Research Center, Juntendo University School of Medicine,
Department of Biological Science and Technology, Tokyo University of Science
House Dust Mite Allergen Induces Atopic Dermatitis via Toll-like Receptor 1 and 6 Triggering of Keratinocytes
Yong Hyun Jang, Weon Ju Lee, Seok-Jong Lee, Do Won Kim
Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea
O2-33
[P11-13]
The novel antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) activates
Panjit Chieosilapatham1,2, François Niyonsaba1, Chanisa Kiatsurayanon1,2, Ko Okumura1, Shigaku Ikeda1,2, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology and
Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 31 -
O2-34
[P11-14]
TGF-β-induced suppression of mast cell functions is mediated by the transcription factor Ehf
Nobuhiro Nakano1, Susumu Yamazaki2, Chiharu Nishiyama1,3, Ko Okumura1, Hideoki Ogawa1,4, Shigaku Ikeda1,4
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Pediatrics and
Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Department of Biological Science and
Technology, Tokyo University of Science, Tokyo, Japan, 4Department of Dermatology and Allergology, Juntendo University Graduate
School of Medicine, Tokyo, Japan
O2-35
[P11-15]
Terminal differentiation of keratinocytes enhances TLR3 expression and anti-viral activity.
Yuriko Yamamura1, Shin Morizane2, Keiji Iwatsuki2
1
Center for Rheumatology, Okayama Saiseikai General Hospital, Okayama, Japan, 2Department of Dermatology, Okayama University
Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
O2-36
[P11-16]
Dissecting out the taxonomic heterogeneity within Propionibacterium acnes and proposal for two novel
subspecies of the species
Itaru Dekio1,2, Renata Culak2, Raju Misra3, Tom Gaulton2, Min Fang2, Masaru Tanaka1, Hans-Peter Klenk4, Dunstan Rajendram5,
Saheer E. Gharbia3, Haroun N. Shah2
1
Department of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan, 2Proteomics Research Unit,
Culture Collections, Public Health England, Colindale, London, United Kingdom, 3Genomic Research Unit, Public Health England,
Colindale, London, United Kingdom, 4School of Biology, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Genomic
Services Unit, Public Health England, Colindale, London, United Kingdom
O2-37
[P11-17]
Effects of antimicrobial peptides on expression of axon guidance molecules in normal human epidermal
keratinocytes
Yoshie Umehara1, Yayoi Kamata1, Mitsutoshi Tominaga1, François Niyonsaba2,3, Hideoki Ogawa1,2, Kenji Takamori1,4
1
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, 2Atopy
(Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo
University, Tokyo, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan
O2-38
[P11-18]
Increased expression of toll like receptors 3, 7, 8, and 9 in peripheral blood mononuclear cells in patients with
psoriasis
Hee Joo Kim, Hong Kyu Kang, Sung Hee Kim, Dong Youn Shin, Dae Suk Kim, Min-Geol Lee
Department of Dermatology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea
O2-39
[P11-19]
Keratolytic and comedolytic effects of topically applied benzoyl peroxide in hairless mice and rhino mice.
Kazuaki Okamoto, Rie Tamura, Keisuke Tabara, Takamichi Kitano, Shoji Kanayama, Hiroko Kido, Tomo Sasaki, Takayasu Moroki,
Fumiaki Ikeda, Tatsumi Matsumoto, Ritsuko Ishii
Research Laboratories, Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan
O2-40
[P13-09]
Delta-like protein 3 promotes proliferation and migration of melanoma via MAPK activation.
Yukiko Kiniwa, Eisaku Ogawa, Aya Uchiyama, Naomi Kumagai, Ryuhei Okuyama
Department of Dermatology, Shinshu University School of Medicine, Nagano, Japan
O2-41
[P13-10]
Immunomodulatory effects of imiquimod cream on tumor-infiltrating leukocytes in B16F10 melanomas
Sadanori Furudate, Taku Fujimura, Aya Kakizaki, Yumi Kambayashi, Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
O2-42
[P13-11]
AT-rich interaction domain-containing protein 3B has a potential to be a new stem cell marker of melanoma
Satoshi Nakahara, Satoshi Fukushima, Junji Yamashita, Yosuke Kubo, Aki Tokuzumi, Azusa Miyashita, Masatoshi Jinnin,
Hironobu Ihn
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, University of Kumamoto, Kumamoto, Japan
O2-43
[P13-12]
Tumor-selective killing and TRAIL sensitization by garlic organosulfur compounds in human melanoma cells: role
of L-type calcium channel
Chinatsu Nakagawa1, Miki Suzuki-Karasaki1, Itsuho Fujikawa1, Toyoko Ochiai1, Yoshihiro Suzuki-Karasaki2,3
1
Department of Dermatology, Nihon University Hospital, Tokyo, Japan, 2Division of Physiology, Department of Biomedical Sciences,
Nihon University School of Medicine, Tokyo, Japan, 3Innovative Therapy Research Group, Nihon University Research Institute of
Medical Science, Tokyo, Japan
O2-44
[P13-13]
Immunohistopathological analysis of immature melanocytes from hair follicles of patients with Rhododenolinduced leukoderma
Ken Okamura1, Rintaro Ohe2, Yuko Abe1, Masao Ueki3, Yutaka Hozumi1, Gen Tamiya4, Kayoko Matsunaga5,
Mitsunori Yamakawa2, Tamio Suzuki1
1
Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan, 2Department of Pathological Diagnostics,
Yamagata University Faculty of Medicine, Yamagata, Japan, 3Biostatistics Center, Kurume University, Kurume, Japan, 4Tohoku
Medical Megabank Organization, Tohoku University, Sendai, Japan, 5Department of Dermatology, Fujita Health University School of
Medicine, Toyoake, Japan
- 32 -
O2-45
[P13-14]
Studies on the Melanosome-Phagocytic Activity of Human Dermal Fibroblast (HDF)
Haruka Kohda1, Mami Ishikawa1, Hirokazu Ishii2, Hideya Ando3, Masamitu Ichihashi4, Takahito Nishikata1
1
Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Japan, 2Marine Biological Laboratory,
Woods Hole, MA, USA, 3Department of Applied Chemistry and Biotechnology, Okayama University of Science, Okayama, Japan,
4
SAISEI MIRAI Clinic Kobe, Kobe, Japan
O2-46
[P13-15]
Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and
AP736 on viability of melanocytes
Chang Seok Lee, Yung Hyup Joo, Heung Soo Baek, Miyoung Park, Jeong Hwan Kim, Hong Ju Shin, Nok Hyun Park,
John Hwan Lee, Young Ho Park, Song Seok Shin, Hae Kwang Lee
Amorepacific R&D Center
O2-47
[P13-16]
Regulatory mechanisms of Emodin isolated from Polygoni Multiflori Ramulus on melanogenesis
Jongsung Lee, Sunghee Jang
Dept. of Genetic Engineering, Sungkyunkwan University, Suwon City, Gyunggi Do, Republic of Korea
O2-48
[P13-17]
Hermansky-Pudlak syndrome type 4: the second case in Japanese
Yuta Araki1, Yoshiyuki Ishii2, Yuko Abe1, Junko Yoshizawa1, Fumiki Okamoto3, Yutaka Hozumi1, Tamio Suzuki1
1
Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan, 2Department of Dermatology, Tsukuba
University School of Medicine, Ibaraki, Japan, 3Department of Ophthalmology, Tsukuba University School of Medicine, Ibaraki, Japan
O2-49
[P13-18]
IMP-3 expression predicts unfavorable prognosis in acral lentiginous melanoma
Yi-Shuan Sheen1,2, Yi-Hua Liao1, Hsien-Ching Chiu1, Shiou-Hwa Jee1, Yih-Leong Chang2, Chia-Yu Chu1
1
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan, 2Graduate Institute of Pathology, College of
Medicine, National Taiwan University and Department of Pathology, National Taiwan University Hospital
O2-50
[P13-19]
Inhibition of melanogenesis by Gaillardia aristata flower extract
Minkyung Kim
Biospectrum Life Science Institute, Sangdaewon-Dong, Seongnam-City, Gyeonggi-Do, Republic of Korea
O2-51
[P13-20]
Diagnostic usefulness of dermoscopy in differentiating lichen aureus from nummular eczema
Min Soo Jang, Myeong Hyeon Yang,
Joon Hee Kim, Kang Hoon Lee, Sang Hwa Han, Kee Suck Suh
Department of Dermatology, Kosin University College of Medicine, Busan, Korea
O2-52
[P13-21]
Comparison of the Q-switched ND: YAG and Ruby lasers in treating semi-permanent make up
Kyu Uang Whang1, Young Lip Park2, Jong Suk Lee3, Ga Hee Jung3, Je Min An1, Kyung O Kim2, Sun Bum Kwon1
1
Department of Dermatology, Soonchunhyang University Hospital, Seoul, Republic of Korea, 2Department of Dermatology,
Soonchunhyang University Hospital, Bucheon, Korea, 3Department of Dermatology, Soonchunhyang University Hospital, Cheonan,
Korea
- 33 -
December 11, 2015, Room C
(Tissue Regeneration Stem Cell and Wound Healing)
!
10:50-12:14
Chairs: Katsuto Tamai, Thomas Krieg, Emi Nishimura
C03-01
[P08-10]
10:50-11:02
Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability
C03-02
[P08-09]
11:02-11:14
From Hair to Heart: Nestin-Expressing Hair Follicle Associated Pluripotent (HAP) Stem Cells Differentiate to
Beating Cardiac Muscle Cells
Daisuke Nanba1,2,5, Chihiro Hiraoka1,2,3, Fujio Toki2,5, Ken Shiraishi4, Koji Sayama4, Hiromasa Miura3, Shigeki Higashiyama1,2
1
Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan, 2Department of Biochemistry
and Molecular Genetics, Graduate School of Medicine, Ehime University, Ehime, Japan, 3Department of Bone and Joint Surgery,
Graduate School of Medicine, Ehime University, Ehime, Japan, 4Department of Dermatology, Graduate School of Medicine, Ehime
University, Ehime, Japan, 5Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University,
Tokyo, Japan
Masateru Yashiro1, Sumiyuki Mii1, Ryoichi Aki1, Yuko Hamada1, Nobuko Arakawa1, Katsumasa Kawahara2,3, Robert M. Hoffman4,5,
Yasuyuki Amoh1
1
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan, 2Department of Physiology, Kitasato
University School of Medicine, 3Department of Cellular & Molecular Physiology, Kitasato University Graduate school of Medical
Sciences, 4AntiCancer, Inc., Ostrow Street, San Diego, CA, 5Department of Surgery, University of California San Diego, CA
C03-03
[P08-07]
11:14-11:26
Endothelialized and innervated 3D skin glycated model
C03-04
[P08-06]
11:26-11:38
Two distinct spontaneous regenerative activities to repair ionizing radiation-induced dystrophy in anagen
follicles
Sebastien Cadau1, Sabrina Leoty-Okombi1, Schinichi Nakajima2,
1
Valerie Andre-Frei1,2
2
BASF Beauty Care Solutions, France, BASF Beauty Creations, Tokyo, Japan
Wen-Yen Huang1, Hsien-Yi Chiu1,2,3, Sung-Jan Lin1,2
1
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Department of Dermatology, National Taiwan
University, 3Department of Dermatology, Hsin-Chu Branch, National Taiwan University Hospital, Hsin-Chu City, Taiwan
C03-05
[P08-05]
11:38-11:50
Hair-follicle associated pluripotent (HAP) stem cells differentiate to beating cardiac tissue sheets
Aiko Yamazaki1, Masateru Yashiro1, Sumiyuki Mii1, Ryoichi Aki1, Yuko Hamada1, Nobuko Arakawa1, Katsumasa Kawahara2,3,
Robert M. Hoffman4,5, Yasuyuki Amoh1
1
Department of Dermatology, Kitasato University School of Medicine, 2Department of Physiology, Kitasato University School of
Medicine, 3Department of Cellular & Molecular Physiology, Kitasato University Graduate school of Medical Sciences, 4AntiCancer,
Inc., Ostrow Street, San Diego, CA, 5Department of Surgery, University of California San Diego, CA
C03-06
[P08-03]
11:50-12:02
Population of pluripotent stem cells Muse cells are possibly self-maintained in human adipose-derived stem cells.
C03-07
[P08-02]
12:02-12:14
Generation of transgene-free induced pluripotent stem cells from keratinocytes of recessive dystrophic
epidermolysis bullosa patient
Takeshi Yamauchi1, Kenshi Yamasaki1, Kenichiro Tsuchiyama2, Saaya Koike1, Setsuya Aiba1
1
Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi, Japan, 2Department of dermatology, Tohoku
University hospital, Miyagi, Japan
Wakana Matsumura, Yasuyuki Fujita, Satoru Shinkuma, Inkin Ujiie, Chihiro Nakayama, Kazuma Matsumoto, Toshifumi Nomura,
Riichiro Abe, Hiroshi Shimizu
Luncheon Seminar 3
"Pursuing optimal solutions for psoriasis comorbidities with biologics"
12:25-13:15
LS3-1
Chairs: Hironobu Ihn, Hideshi Torii
Clinical stratification of psoriasis∼can we optimize the treatment?
Shinichi Imafuku
Department of Dermatology, Faculty of Medicine, Fukuoka University
LS3-2
Proactive approach by biologics in psoriasis treatment
Daisuke Tsuruta
Department of Dermatology, Osaka City University Graduate School of Medicine
Co-sponsored by Janssen Pharmaceutical K.K.
- 34 -
(Photobiology)
15:45-16:57
C06-01
[P12-10]
15:45-15:57
Chairs: Yoshiki Tokura, Akimichi Morita
Enhancement of UVB-induced apoptosis and elimination of DNA damages by pre-irradiation of IRA does not
depend on the repair of DNA damages
Shizuka Okazaki, Yoko Funasaka, Seiji Kawana, Hidehisa Saeki
Department of Dermatology, Nippon Medical School, Tokyo, Japan
C06-02
[P12-09]
15:57-16:09
Comparisons of the effects of single and multi-wavelength irradiation photodynamic therapy using 5aminolevulinic acid
Hideyuki Masuda1,2, Makoto Kimura1,2, Akimichi Morita1
1
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya,
Japan, 2USHIO INC.
C06-03
[P12-06]
16:09-16:21
Usefulness of flow-cytometry based nucleotide excision repair assay for diagnosis of xeroderma pigmentosum
variant type
Eiji Nakano, Seiji Takeuchi, Taro Masaki, Ryusuke Ono, Chikako Nishigori
Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan
C06-04
[P12-04]
16:21-16:33
AhR-dependent COX-2 upregulation is involved in the mechanisms underlying voriconazole-induced UVassociated skin cancer development
Shigeki Ikeya, Jun-ichi Sakabe, Yoshiki Tokura
Department of Dermatology, Hamamatsu University School of Medicine, Shizuoka, Japan
C06-05
[P12-02]
16:33-16:45
Longer wavelength UVB irradiation induces HMGB1 in keratinocytes without causing apoptosis
C06-06
[P12-03]
16:45-16:57
Ultraviolet B (UVB) exposure expands thymus-derived Foxp3＋CD4＋ regulatory T cells with distinctive phenotype
in the skin
Kan Torii, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan
Sayuri Yamazaki1, Mizuyu Odanaka1, Akiko Nishioka2, Saori Kasuya2, Shoryu Takayama1, Masaki Imai1, Osamu Taguchi2,
Akimichi Morita2
1
Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 2Department of Geriatric
and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
Sweets Seminar 3
17:10-17:55
SS3
Chair: Mamitaro Ohtsuki
Inflammatory immune cells orchestrating in psoriasis.
Kenshi Yamasaki
Co-sponsored by Janssen Pharmaceutical K.K.
One-minute presentation III
(Tissue Regeneration Stem Cell and Wound Healing, Photobiology,
Carcinogenesis Growth Factors Signal Transduction Cancer Genetics, Cell
Adhesion Matrix Vascular Biology, Epidemiology Health Service Research,
Human Clinical Research and Therapeutics, Epidermal Structure and Function)
!
! !
!
!
!
!
18:00-19:00
O3-01
[P08-04]
Chair: Yumi Aoyama
Hyaluronan catabolism modulates macrophage polarization and wound repair
Jun Muto1, Daisuke Watanabe1, Richard L. Gallo2
1
Department of Dermatology, Aichi Medical University, Nagakute, Japan, 2Department of Dermatology, University of California, San
Diego, La Jolla
- 35 -
O3-02
[P08-08]
Long-term maintenance and proliferation of murine skin epithelial stem cells by Wnt-3a in vitro
Yukiteru Ouji, Fukumi Nakamura-Uchiyama, Masahide Yoshikawa
Department of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Japan
O3-03
[P08-11]
TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury
Yelin Wu
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China
O3-04
[P08-12]
Whisker follicles transplanted to the spine of nude mice for spinal cord repair generate extensive ectopic hair
growth
Wenluo Cao1,2,3, Lingna Li1, Sumiyuki Mii4, Yasuyuki Amoh4, Fang Liu3,
1
Robert M. Hoffman1,2
AntiCancer Inc., San Diego, CA, Dept of Surgery, University of California, San Diego, CA, 3Dept of Anatomy, Second Military
Medical University, Shanghai, China, 4Dept of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan
O3-05
[P08-13]
2
High glucose suppresses DDX5 to delay wound healing in diabetic mice
Hongquan Li, Wang Wang, Yuping Lai
O3-06
[P08-14]
Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche
Takaaki Yamada1,2,3, Seiji Hasegawa1,3,4, Yu Inoue1, Yasushi Date1,4, Akiko Yagami3, Naoki Yamamoto5, Satoru Nakata1,
Kayoko Matsunaga3, Hirohiko Akamatsu2
Research Laboratories, Nippon Menard Cosmetic Co., Ltd., 2Department of Applied Cell and Regenerative Medicine, Fujita Health
University School of Medicine, Aichi, Japan, 3Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan,
4
Nagoya University-Menard Collaborative Research Chair, Nagoya University Graduate School of Medicine, Aichi, Japan, 5Laboratory
of Molecular Biology, Fujita Health University Joint Research Laboratory, Aichi, Japan
1
O3-07
[P08-15]
Silk fibroin produced by transgenic silkworms overexpressing the Arg-Gly-Asp motif accelerates cutaneous
wound healing in mice
Atsunori Baba1, Kasumi Kitayama2, Tetsuo Asakura2, Hideki Sezutsu3, Akihide Tanimoto4, Takuro Kanekura1
1
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan,
Department of Biotechnology, Tokyo University of Agriculture and Technology, 3Transgenic Silkworm Research Unit, National
Institute of Agrobiological Sciences, 4Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of
Medical and Dental Sciences
2
O3-08
[P08-16]
Antiaging property of Andrographis paniculata extract
Ji-young You, Kyung-Baeg Roh, Deokhoon Park, Eunsun Jung
Biospectrum, Korea
O3-09
[P08-17]
Phlorizin increases epidermal thickness and p63 positive cells with increased expression of type IV Collagen and
inhibition of MiR135b
Young-Ji Hwang1, Hye-Ryung Choi1, Kazumi Toyama2, Jung-Won Shin1, Kyoung-Chan Park1
1
Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Republic of Korea, 2P&G Group,
Kobe, Japan
O3-10
[P08-18]
Mechanism of Aloe vera gel on wound healing in human epidermis
Mariko Moriyama1, Hirokazu Kubo1, Yuka Nakajima1, Arisa Goto1, Junji Akaki2, Ikuyo Yoshida2, Yukio Nakamura2,
Takao Hayakawa1, Hiroyuki Moriyama1
1
Pharmaceutical Research and Technology Institute, Kindai University, Osaka, Japan, 2Kobayashi Pharmaceutical Co., Ltd., Osaka,
Japan
O3-11
[P08-19]
Hierarchy of Cells and Roles of Stem Cells in the Dermis
Yuichi Hasebe1,2, Seiji Hasegawa1,2,3, Yuichirou Ogata1, Satoru Nakata1, Masashi Toyoda4, Kenji Matsumoto5, Akihiro Umezawa6,
1
NIPPON MENARD COSMETIC CO., LTD, 2Nagoya University-MENARD Collaborative Reserch Chair Nagoya University Graduate
School of Medicine, Aichi, Japan, 3Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan, 4Research
Team for Geriatric Medicine (vascular medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, 5Department of Allergy
and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, 6Department of Reproductive
Biology, National Research Institute for Child Health and Development, Tokyo, Japan, 7Department of Applied Cell and Regenerative
Medicine, Fujita Health University School of Medicine, Aichi, Japan
O3-12
[P08-20]
Role of topical or systemic corticosteroid application on hot water-induced mouse burn models of various grades
Naotaka Doi, Yumi Nakatani, Yutaka Inaba, Nobuo Kanazawa, Fukumi Furukawa
Dermatology, Wakayama Medical University, Wakayama, Japan
O3-13
[P12-05]
Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat
cells
Eun Ju Kim1,2,3, Yeon Kyung Kim1,2,3, Sungsoo Kim1,2,3, Ji Eun Kim1,2,3,
1
Dong Hun Lee1,2,3, Jin Ho Chung1,2,3,4
Department of Dermatology, Seoul National University College of Medicine, 2Laboratory of Cutaneous Aging Research, Biomedical
Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, 3Institute of Human-Environment Interface Biology,
Seoul National University, Seoul, Republic of Korea, 4Institute on Aging, Seoul National University, Seoul, Republic of Korea
- 36 -
O3-14
[P12-07]
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in
human skin
Dong Hun Lee1,2,3, Eun Ju Kim1,2,3, Yeon Kyung Kim1,2,3, Sungsoo Kim1,2,3,
Jin Ho Chung1,2,3,4
1
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea, 2Laboratory of Cutaneous
Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, 3Institute of HumanEnvironment Interface Biology, Seoul National University, Seoul, Republic of Korea, 4Institute on Aging, Seoul National University,
Seoul, Republic of Korea
O3-15
[P12-08]
UV irradiation-induced production of monoglycosylated biglycan through downregulation of xylosyltransferase 1
in human dermal fibroblasts
Jang-Hee Oh1,2,3, Cheng Long Jin1,2,3,4, Mira Han1,2,3, Min Kyeong Shin1,2,3, Cheng Yao1,2,3, Chi-Hyun Park1,2,3,
Mira Choi1,2,3, Yeon Kyung Kim1,2,3, Se-Rah Lee1,2,3, Xinghua Yuan1,2,3,4, Zhe Hu Jin4, Jin Ho Chung1,2,3
Hanon Lee1,2,3,
1
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea, 2Laboratory of Cutaneous Aging
Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, 3Institute of Human-Environment Interface
Biology, Medical Research Center, Seoul National University, Seoul, Korea, 4Department of Dermatology, Yanbian University
Hospital, Yanji, Jilin, China
O3-16
[P12-11]
The Distinct Effect of UVB and Near-infrared Radiation on Sebum Secretion in Differentiated Hamster Sebocytes
Shoko Ojima1, Noriko Akimoto1, Hiroko Sugimoto1, Shiho Tanaka1,2, Mana Hirayama1,3, Yuko Takenaka1,3, Yuichiro Tsunemi3,
Makoto Kawashima3, Takashi Sato1
1
Department of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 2Aoyama Institute of Women´s
Medicine, Tokyo Women´s Medical University, Tokyo, Japan, 3Department of Dermatology, Tokyo Women´s Medical University,
Tokyo, Japan
O3-17
[P12-12]
A novel effects of a novel ascorbic acid derivative, 3-O-laurylglyceryl ascorbate, on improvement of skin barrier
Yushi Katsuyama1, Tatsuya Tsuboi1, Sayaka Nakamura1, Norihisa Taira1, Hitoshi Masaki2, Masato Yoshioka1
1
O3-18
[P12-13]
SEIWA KASEI CO., LTD. Osaka, Japan, 2Tokyo University of Technology
Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of
HSP70-inducers
Keiko Usui1, Tsuyoshi Ikeda2, Keiko Inoue3, Kenichi Hamada3, Tohru Mizushima1
1
Department of Drug Discovery and Development, Faculty of Pharmacy, Keio University, Tokyo, Japan, 2Faculty of Pharmaceutical
Sciences, Sojo University, Kumamoto, Japan, 3Saishunkan Phamaceutical Co., ltd.
O3-19
[P12-14]
Carbonylated proteins in the stratum corneum generate reactive oxygen species under short wavelength visible
light
Taeko Mizutani, Yumiko Yamawaki, Yuri Okano, Hitoshi Masaki
School of Bioscience and Biotechnology, Tokyo University of Technology
O3-20
[P12-15]
The Effect of Near-infrared Radiation on the Skin of Hamsters
Misaki Minemura1, Noriko Akimoto1, Hiroko Sugimoto1, Shiho Tanaka1,2, Mana Hirayama1,3, Yuko Takenaka1,3, Yuichiro Tsunemi3,
1
Tokyo, Japan
O3-21
[P12-16]
The effects of inaudible ultrasound on UV-irradiated human skin equivalent
Hyangtae Choi
Skin Research Team, R&D center, Amorepacific Co. LTD., Korea
O3-22
[P12-17]
The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people―the
relationship with the usage―
Makoto Mizuno1,2, Kayo Kunimoto1, Mikiko Seigan1, Eiji Naru2, Koichi Kameyama2, Fukumi Furukawa1, Yuki Yamamoto1,3
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Fundamental Research Laboratories, KOSÉ
Corporation, 3Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University
O3-23
[P12-18]
Up-regulation of expression of Heme oxygenase-1 by Psidium guajava extract
Yuumi Horibe2, Yoshiki Okita1, Keiko Usui1, Keiko Inoue2, Kenichi Hamada2, Tohru Mizushima1
1
Department of Drug Discovery and Development, Faculty of Pharmacy, Keio University, Tokyo, Japan, 2Saishunkan Phamaceutical
Co., Itd
O3-24
[P02-04]
Effects of macrophage migration inhibitory factor on heat-induced apoptosis in keratinocytes
Yoko Yoshihisa1, Mati Ur Rehman1,2, Takashi Kondo2, Tadamichi Shimizu1
1
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan,
2
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama,
Japan
- 37 -
O3-25
[P02-06]
!
The sphingosine-1-phosphate S1PR1 axis as a potential therapeutic target in angiosarcoma
Daigo Oka1,2, Risa Koresawa1, Hideyo Fujiwara1, Hirotake Nishimura1, Isao Irei1, Takashi Akiyama1, Shuji Hamazaki1,
Yoshito Sadahira1, Wataru Fujimoto2, Mikio Masuzawa3
1
The First Department of Pathology, Kawasaki Medical University, Okayama, Japan, 2Department of Dermatology, Kawasaki Medical
University, Okayama, Japan, 3Department of Pathology Chemical, Allied Health Sciences, Kitasato University, Kanagawa, Japan
O3-26
[P02-08]
Epidermal growth factor receptor inhibitor induces TNFα via activation of the PPARγ and NF-κB in sebocytes
Atsuko Ashida, Eisaku Ogawa, Ryuhei Uchiyama, Hisashi Uhara, Ryuhei Okuyama
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
O3-27
[P02-09]
Identification of novel receptor tyrosine kinases in basal cell carcinoma
Hiroshi Mitsui1, James G. Krueger2, John A. Carucci3, Tatsuyoshi Kawamura1, Shinji Shimada1
1
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Japan, 2Laboratory for Investigative Dermatology, the
Rockefeller University, USA, 3Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, USA
O3-28
[P02-10]
Oxidative damage and Nrf2 (Nuclear factor erythroid 2-related factor 2) protein expression in normal skin and
keloid tissues
Kyu Uang Whang1, Jong Suk Lee3, Sung Yul Lee3, Je Min An1, Kyung O Kim2, Sun Bum Kwon1, Hyun ju Kim2
1
Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea, 2Department of Dermatology,
Soonchunhyang University College of Medicine, Bucheon, Korea, 3Department of Dermatology, Soonchunhyang University College
of Medicine, Cheonan, Korea
O3-29
[P02-11]
Triptolide induces antitumor activity in human melanoma cells via inhibiting transactivation of heat shock factor 1
Yoshitaka Nakamura, Yuko Nakatani, Akiko Nakamura, Masahiko Muto
Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
O3-30
[P02-12]
FAK and Src expression in premalignant and malignant skin lesions
Chong Won Choi1, Yoon Hwan Kim2, Hyunjoo Lee3, Won-Serk Kim2
1
3
O3-31
[P03-06]
Department of Dermatology, Seoul National University, Seoul, Korea, 2Department of Dermatology, Kangbuk Samsung Hospital,
Department of Pathology, Kangbuk Samsung Hospital
Epitope reduction of anti-desmoglein 1 autoantibodies in pemphigus foliaceus patients sera during clinical stages.
Yumi Aoyama1, Koji Kamiya2, Osamu Yamasaki3, Ken Ishii4, Aki Kamata5, Jun Yamagami5, Yoshiki Tokura2, Keiji Iwatsuki3
1
Department of Dermatology, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan, 2Department of Dermatology,
Hamamatsu University School of Medicine, Hamamatsu, Japan, 3Department of Dermatology, Okayama University Graduate School
of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 4Department of Dermatology, Toho University Omori Medical
Center, Tokyo, Japan, 5Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
O3-32
[P03-07]
Extra- and intracellular activities of COMP control collagen homeostasis in skin and fibrotic diseases.
Thomas Krieg, Beate Eckes
Department of Dermatology, Medical Faculty, University of Cologne, Cologne, Germany
O3-33
[P03-08]
Regulation of IL-33 expression is associated with keratinocyte adhesion, but not with differentiation.
Mayumi Komine1,2, Jitlada Meephansan3, Hidetoshi Tsuda1, Tomoyuki Oshio1, Shin-ichi Tominaga2, Mamitaro Ohtsuki1
1
Department of Dermatology, Jichi Medical University, 2Department of Biochemistry, Jichi Medical University, 3Department of
Dermatology, Chulabhorn International College of Medicine, Thammasat University
O3-34
[P03-09]
The role of basement membrane components on psoriasis in mice
Aki Natsumi, Koji Sugawara, Yukari Mizukami, Hisayoshi Imanishi, Daisuke Tsuruta
Department of Dermatology, Osaka City University Grduate School of Medcine, Osaka, Japan
O3-35
[P03-10]
Sebaceous Gland is a Hyaluronan Synthesis Organ in the Skin
Noriko Akimoto, Takashi Sato
Department of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
O3-36
[P03-11]
Profile of upregulated molecules in keloids
Misachi Asai1, Kazuya Kashiyama2, Yutaka Kuwatsuka1, Tatsushi Kiyohara1, Yumi Okubo1, Atsushi Utani1
1
Department of Dermatology, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Plastic
and Reconstructive Surgery, Tomishiro Central Hospital
O3-37
[P06-01]
Anti-aging Effects of Camellia Japonica flower extract on a pollutant-induced stress
Seoungwoo Shin, Minkyung Kim, Eunsun Jung, Deokhoon Park
O3-38
[P04-29]
Effects of topical agents containing VD3 analogues on serum calcium level in rats
Maho Hirabe1, Atsushi Hosomi1, Takuya Tokuda1, Hiroaki Nakamura1, Toru Amano1, Tadao Okamoto2
1
Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan, 2Leo Pharma K.K., Tokyo, Japan
- 38 -
O3-39
[P04-30]
Evaluation of an anti-dandruff treatment schedule against chronic recurrent seborrheic dermatitis
Virginie Turlier1, Cecile Viode1, Ophelie Lejeune1, Amandine Rouquier1, Christiane Casas1, Daniel Redoules1, Valerie Mengeaud1,
Jean-Baptiste Grieu2, Anne-Marie Schmitt1
1
Skin Research Center Pierre Fabre Dermo-Cosmétique Toulouse, France, 2Asian Innovation Center Pierre Fabre Dermo-Cosmétique,
Tokyo, Japan
O3-40
[P04-31]
Analysis of hair minerals in children with atopic dermatitis
Jeoung Eun Kim, Jae Min Shin, Won Seon Koh, Joo Yeon Ko, Young Suck Ro
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea
O3-41
[P04-32]
!
Efficacy and safety of the interleukin-12 interleukin-23 antagonist ustekinumab in Korean patients with moderate
to severe psoriasis
Kyu Uang Whang1, Young Lip Park2, Kyung O Kim2, Je Min An1, Sun Bum Kwon1, Jong Suk Lee3, Ga Hee Jung3
1
Department of Dermatology, Soonchunhyaung University Hospital, Seoul, Korea, 2Department of Dermatology, Soonchunhyaung
University Hospital, Bucheon, Korea, 3Department of Dermatology, Soonchunhyaung University Hospital, Cheonan, Korea
O3-42
[P04-33]
Fingernail Onychomycosis Caused by Molds: Epidemiology, Clinical and Laboratory characteristics
Charussri Leeyaphan, Sumanas Bunyaratavej, Sutasinee Phaitoonwattanakij, Chanai Muanprasat, Lalita Matthapan
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University
O3-43
[P04-34]
Usefulness of ultrasonography for rapidly diagnosing cutaneous sinus tracts of dental origin
Chinatsu Shobatake1, Fumi Miyagawa1, Takaya Fukumoto1, Toshiko Hirai2, Nobuhiko Kobayashi1, Hideo Asada1
1
Department of Dermatology, Nara Medical University, Nara, Japan, 2Department of Endoscopy and Ultrasound, Nara Medical
University, Nara, Japan
O3-44
[P04-35]
Histological analysis of the treatment for melasma and solar lentigo with low-fluence Q-Switched 1,064-nm Nd:
YAG Laser.
Chikako Kaminaka1,2, Fukumi Furukawa1, Yuki Yamamoto1,2
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Department of Cosmetic Dermatology and
Photomedicine, Wakayama Medical University, Wakayama, Japan
O3-45
[P04-36]
Clinical trial for evaluation of the efficacy and safety of monochromatic red and polychromatic white LED
devices for periocular wrinkles
Seung-Phil Hong, Chanhee Nam, Minyoung Jung, Misoo Choi, Minkee Park, Byungcheol Park, Myunghwa Kim
Department of Dermatology, Dankook University College of Medicine, Cheonan, Republic of Korea
O3-46
[P05-24]
Inhibitory factors of semaphorin 3A expression in human epidermal keratinocytes
Yayoi Kamata1, Yoshie Umehara1, Mitsutoshi Tominaga1, Osamu Negi2, Hideoki Ogawa1, Kenji Takamori1,2
1
2
O3-47
[P05-25]
Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan,
Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan
Analysis of micro-inflammation in human keratinocytes by quantitative measurement of mechanical property
changes
Hyeongwon Choi1,
Min Kyung Shin2, Hey Jin Ahn2, Youngsook Son3, Hun-Kuk Park4, Kyung Sook Kim5
1
Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yong In,
Korea, 2Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea, 3Kyung Hee Institute of Regenerative
Medicine, Seoul, Korea, 4Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, Korea, 5Program
of Medical Engineering College of Medicine, Kyung Hee University, Seoul, Korea
O3-48
[P05-26]
!
Host defense protein S100A7 psoriasin regulates pores in the epidermis: aquaporins and tight junctions
Fumihiro Hattori1,2, Shigaku Ikeda1,3, Ko Okumura3, Mitsutoshi Tominaga4, Kenji Takamori4, Hideoki Ogawa3,
Kikumoto Okamoto2,5, François Niyonsaba3
1
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Mikimoto
Pharmaceutical Co., Ltd., Mie, Japan, 3Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo,
Japan, 4Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan,
5
Juntendo Clinical Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
O3-49
[P05-27]
Sandalwood oil enhanced Epithelial-Mesenchymal Transition and promoted wound healing
Sayaka Matsumura, Saori Itoi-Ochi, Mika Terao, Hiroyuki Murota, Ichiro Katayama
O3-50
[P05-28]
The presence of Glyceraldehyde-derived AGEs in the skin
Mami Yokota1, Yuri Okano2, Hitoshi Masaki2, Masayoshi Takeuchi3, Yoshihiro Tokudome1
1
Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, 2School of Bioscience and
Biotechnology, Tokyo University of Technology, 3Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical
University
- 39 -
O3-51
[P05-29]
Phosphate buffered saline induces filaggrin expression in a human epidermal keratinocyte cell line (HaCaT cells)
Kozo Nakai1, Kozo Yoneda1, Toshitaka Nakagawa2, Tetsuya Moriue1, Yasuo Kubota1
1
Department of Dermatology, Kagawa University, Kagawa, Japan, 2Department of Life Science Research Center, Kagawa University,
Kagawa, Japan
O3-52
[P05-30]
A novel imaging technique for skin dermal viscoelasticity and its correlation with dermal density
Min Ah Kim, Sun Young Park, Hae Kwang Lee, John Hwan Lee
Skin Research Institute, Amorepacific R&D Center, Yongin, Korea
O3-53
[P05-31]
Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda
Teruhiko Makino, Megumi Mizawa, Yuri Seki, Masao Hayashi, Tadamichi Shimizu
Department of Dermatology, University of Toyama, Toyama, Japan
- 40 -
Morning Seminar 1
"Emerging evidence of IL-17A in psoriasis pathogenesis"
8:00-8:50
MS1-1
Chairs: Masayuki Amagai, Chikako Nishigori
Anti-IL-17A antibody secukinumab reverses disease-defining psoriasis histopathology
Frank Kolbinger
Novartis Institutes for BioMedical Research, Basel, Switzerland
MS1-2
Th17-related pathogenesis, biologic therapies and biomarkers in psoriasis
Yoshiki Tokura
Co-sponsored by Novartis Pharma K.K.
(Autoimmunity Inflammation, Immunology 1: Adaptive Immunity)
!
8:55-10:31
Chairs: Hyunjung Kim, Riichiro Abe, Kenji Kabashima
C07-01
[P01-08]
8:55-9:07
The role of purinergic signaling in development of irritant dermatitis of acrodermatitis enteropathica
C07-02
[P01-07]
9:07-9:19
Vitamin D analogue MC903 improves imiquimod-induced psoriatic skin lesion via directly inhibiting IL-23
production by Langerhans cells
Youichi Ogawa, Tatsuyoshi Kawamura, Takamitsu Matsuzawa, Rui Aoki, Shinji Shimada
Dermatology, University of Yamanashi
Nobuhiro Kusuba, Akihiko Kitoh, Kenji Kabashima
C07-03
[P01-05]
9:19-9:31
Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid
C07-04
[P01-06]
9:31-9:43
Lymph node stromal cell-mediated deletional tolerance controls the development of GVHD-like skin lesion in
involucrin-mOVA mice
Kentaro Izumi, Wataru Nishie, Yosuke Mai, Mayumi Wada, Ken Natsuga, Hideyuki Ujiie, Hiroaki Iwata, Hiroshi Shimizu
Yujin Nakagawa1, Gyohei Egawa1, Tetsuya Honda1, Jun-ichi Sakabe2, Kenji Kabashima1
1
Department of Dermatology, Kyoto University Graduate School of Medicine, 2Agency for Science, Technology and Research,
Singapore
C07-05
[P10-05]
9:43-9:55
Skin resident CD8+ T cells display low cytotoxic potential in healthy skin and fail to fully mature in primary
melanoma lesions
Judith A. Seidel1,4, Sian H. Henson1, Natalie Riddell1, Milica Vukmanovic-Stejic1, Malcolm H. Rustin2, Frank Nestle3, Katie Lacy3,
Arne N. Akbar1
1
4
C07-06
[P10-04]
9:55-10:07
University College London, 2Royal Free Hospital, London, United Kingdom, 3Kings College London, London, United Kingdom,
Kyoto University, Japan
EpCAM Expressed by Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously-applied Protein
Antigen
Takeshi Ouchi1,2, Mark_C Udey1
1
Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, 2Department of Dermatology, Keio University
C07-07
[P10-03]
10:07-10:19
Immunological function of Langerhans cells in HIV in vitro and ex vivo infection
C07-08
[P10-02]
10:19-10:31
Contribution of basophil-derived amphiregulin in prurigo-like skin inflammation
Takamitsu Matsuzawa1, Tatsuyoshi Kawamura1, Youichi Ogawa1, Hiroaki Mitsuya2, Shinji Shimada1
1
Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Infectious Diseases and Department of Hematology,
Kumamoto University School of Medicine, Kumamoto, Japan
Takashi Hashimoto1,2,3, Takahiro Satoh1, Hiroo Yokozeki2
1
Department of Dermatology, National Defense Medical College, Saitama, Japan, 2Department of Dermatology, Graduate School,
Tokyo Medical and Dental University, Tokyo, Japan, 3Department of Dermatology, Yokohama City Minato Red Cross hospital,
Yokohama, Japan
- 41 -
Plenary Session II
10:40-12:10
II-1
[P01-01]
10:40-10:55
Chairs: Richard Gallo, Masayuki Amagai, Tilo Biedermann
The impact of Fli1 deficiency in B cells on the development of systemic sclerosis.
Ryosuke Saigusa1, Yoshihide Asano1, Kouki Nakamura1, Shunsuke Miura1, Takashi Yamashita1, Yohei Ichimura1,
Takehiro Takahashi1, Tetsuo Toyama1, Takashi Taniguchi1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Arthritis Center, Boston University
School of Medicine, Boston, Massachusetts
II-2
[P13-01]
10:55-11:10
Novel non-cell autonomous role of epidermal polarity protein Par3 in melanocyte homeostasis and
melanomagenesis
Melina Mescher1,2, Matthias Ruebsam1,3, Peter Jeong1, Marina Kranen1, Jennifer Landsberg4, Max Schlaak3, Cornelia Mauch3,
Carien M. Niessen1,2,3, Thomas Tueting4, Sandra Iden1,2
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany, 2Center for Molecular Medicine Cologne, University of
Cologne, Cologne, Germany, 3Department of Dermatology, University of Cologne, Cologne, Germany, 4Department of Dermatology
and Allergy, University of Bonn, Bonn, Germany
1
II-3
[P03-01]
11:10-11:25
Anti-CX3CL1 monoclonal antibody: a promising therapy for systemic sclerosis
Vu H. Luong1, Takenao Chino1, Atsushi Tokuriki1, Noritaka Oyama1, Minoru Hasegawa1, Yoshikazu Kuboi2, Takashi Obara2,
Nobuyuki Yasuda2, Kenzo Muramoto3, Toshio Imai3
1
II-4
[P07-01]
11:25-11:40
The Department of Dermatology-Fukui University, 2Eisai Co., Ltd., 3KAN Research institute. Inc.
Mutations of zinc finger E-box binding homeobox 2 (ZEB2) leading to develop connecting tissue disorder similar
to Ehlers-Danlos syndrome
Mika Teraishi1, Mikiro Takaishi1, Kimiko Nakajima1, Seiji Mizuno2, Yoko Hiraki3, Toshiyuki Fukada4, Shinji Shimoda5,
Yoshinobu Asada6, Nobuaki Wakamatsu2, Takahisa Furukawa7, Shigetoshi Sano1
1
Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan, 2Department of Clinical Genetics, Central
Hospital, Aichi Human Service Center, Kasugai, Japan, 3Hiroshima Municipal Center for Child Health and Development, Hiroshima,
Japan, 4Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, 5Department of Anatomy-1, Tsurumi
University School of Dental Medicine, Yokohama, Japan, 6Department of Pediatric Dentistry, Tsurumi University School of Dental
Medicine, Yokohama, Japan, 7Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University,
Suita, Japan
II-5
[P11-01]
11:40-11:55
IL-17 produced by group 3 innate lymphoid and γδT cells is pivotal for host defense to epicutaneous candidiasis
via neutrophil activation
Mari T. Iwasawa1, Yuumi Nakamura1, Seiichiro Wakabayashi1, Shinobu Saijo2, Hiroyuki Matsue1
1
The Department of Dermatology, Chiba University, Chiba, Japan, 2Medical Mycology Research Center, Chiba University, Chiba,
Japan
II-6
[P05-01]
11:55-12:10
Homeostatic cell turnover mechanisms that maintain tight junction barrier integrity in the epidermis
Mariko Yokouchi1,2, Mayumi Kajimura3, Makoto Suematsu3, Mikio Furuse4, Masayuki Amagai1, Akiharu Kubo1
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Nerima General Hospital, 3Department of
Biochemistry & Integrative Medical Biology, 4Division of Cerebral Structure, National Institute for Physiological Sciences
Luncheon Seminar 4
"New pathogenesis of psoriasis and its therapeutic target, IL-17A"
12:20-13:10
LS4-1
Chair: Ichiro Katayama
Pathogenesis of Psoriasis and the Effect of Anti-IL-17 Antibody Therapy
Mayumi Komine
Department of Dermatology, Jichi Medical University
LS4-2
What is the optimal treatment goal to treat not only skin manifestations, but also psoriasis patient?
Keiichi Yamanaka
Department of Dermatology, Mie university
!
Co-sponsored by Maruho Co., Ltd. Novartis Pharma K.K.
Plenary Session III
13:15-14:30
III-1
[P04-01]
13:15-13:30
Chairs: Alice Pentland, Shinji Shimada, Nikolas Haass
Regulatory B cells are functionally impaired in patients with psoriasis
Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Hidemi Nakagawa
- 42 -
III-2
[P05-02]
13:30-13:45
Re-innervation of a skin model; functionality study
Valerie Andre-Frei1, Christine Jeanmaire1, Jean-Pierre Pennec3, Carine Tedeschi1, Schinichi Nakajima4, Laurent Misery2,
Nicolas Lebonvallet2
1
BASF Beauty Care Solutions, France, 2Laboratory of Neurosciences, Faculty of Medicine, Brest, France, 3Faculty of Medicine and
Health Science, University of Brest, 4BASF Beauty Creations, Tokyo
III-3
[P13-02]
13:45-14:00
Disruption of the autophagy-lysosome pathway is involved in hypopigmented macules in patients with tuberous
sclerosis complex
Lingli Yang, Fei Yang, Mari Wataya-Kaneda, Ichiro Katayama
Department of dermatology, Osaka University
III-4
[P02-01]
14:00-14:15
Artemin-administered mice develop thermohyperesthesia of skin via central sensitization to heat
III-5
[P01-02]
14:15-14:30
Am80 ameliorates fibrosis, inflammation, and vasculopathy in animal models of systemic sclerosis
Hiroyuki Murota1, Yuki Mori2, Yoshichika Yoshioka2, Ichiro Katayama1
1
Depatment of Dermatology, Osaka University, Osaka, Japan, 2Biofunctional Imaging, Immunology Frontier Research Center, Osaka
University, Osaka, Japan
Tetsuo Toyama1,2, Yoshihide Asano1, Kouki Nakamura1, Takashi Yamashita1, Ryosuke Saigusa1, Takehiro Takahashi1,
Yohei Ichimura1, Takashi Taniguchi1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
School of Medicine
(Autoimmunity Inflammation)
!
14:35-16:11
C10-01
[P01-19]
14:35-14:47
Chairs: Dedee Murrell, Michel Gilliet, Hiroo Yokozeki
Impaired expression of the antimicrobial protein REG3A exacerbates TLR3-mediated inflammation in diabetic
skin wounds
Yelin Wu1, Yuanqi Liu1, Yanchun Quan1, Keiwei Liu1, Hongquan Li1, Ziwei Jiang1, Tian Zhang1, Hu Lei1, Katherine Radek2,
Dongqing Li1, Zhenhua Wang1, Jilong Lu1, Zhaofan Xia3, Yuping Lai1
1
School of Life Sciences, East China Normal University, Shanghai, China, 2Department of Surgery, Burn and Shock Trauma Research
Institute, Loyola University Chicago, Health Sciences Campus, Maywood, 3Burn Institute of Chinese PLA and Department of Burn
Surgery, Changhai Hospital, Second Military Medical University, Shanghai
C10-02
[P01-18]
14:47-14:59
!
Monocyte-derived IP-10 has a major role in the pathogenesis of sustained progressing phenotypes in NakajoNishimura syndrome
Nobuo Kanazawa1, Yumi Nakatani1, Yutaka Inaba1, Kayo Kunimoto1, Fukumi Furukawa1, Fumiko Ozaki2
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Center for iPS Cell Research and Application,
Kyoto University, Kyoto, Japan
C10-03
[P01-17]
14:59-15:11
The antifibrotic effect of α2AP neutralization in systemic sclerosis dermal fibroblasts and mouse models of
systemic sclerosis
Yosuke Kanno1, En Shu2, Hiroyuki Kanoh2, Mariko Seishima2
1
Doshisha Women’s Collage of Liberal Arts, 2Gifu University Graduate School of Medicine
C10-04
[P01-16]
15:11-15:23
Activation of p38 MAPK mediates the induction of murine psoriatic dermatitis
C10-05
[P01-15]
15:23-15:35
Leptin may enhance IL-6 production via decreased expression of caveolin-1 in human keratinocytes
C10-06
[P01-12]
15:35-15:47
Regnase-1 of the epidermis plays a regulatory role in inflammatory response to irritative innate stimuli, but not
to contact allergy.
Kenji Sakurai, Teruki Dainichi, Reiko Matsumoto, Yuri Nakano, Kenji Kabashima
Yuko Watanabe, Yukie Yamaguchi, Noriko Komitsu, Michiko Aihara
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
!
Mikiro Takaishi1, Takashi Satoh2, Shizuo Akira2, Shigetoshi Sano1
1
Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan, 2Department of Host Defense, Research
Institute for Microbial Diseases, Osaka University, Suita, Japan
C10-07
[P01-09]
15:47-15:59
!
Recruitment, activation and function of monocytes macrophage in skin wound healing
Sebastian Willenborg1, Nhu-Nguyen Do1, Xiaolei Ding1, Geert van Loo2, Manolis Pasparakis3,4,5, Sabine A. Eming1,4,5
1
Department of Dermatology, University of Cologne, Cologne, Germany, 2Department for Molecular Biomedical Research, VIB and
Department of Biomedical Molecular Biology, Ghent University, Belgium, 3Institute for Genetics, University of Cologne, Cologne,
Germany, 4Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, 5Cologne Excellence Cluster on
Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany
- 43 -
C10-08
[P01-10]
15:59-1611
Upregulation of interleukin-33 receptor expression on basophils in human atopic dermatitis; interaction of
scratching and IL-33 production
Yumi Nonomura, Atsushi Otsuka, Chisa Nakashima, Kenji Kabashima
Sweets Seminar 4
"Hot topics in 2015"
17:00-17:45
SS4-1
Chair: Keiji Iwatsuki
The comprehensive human biology for the future generation preventive medicine
Fumihiko Matsuda
The Center for Genomic Medicine, Kyoto University Graduate School of Medicine
SS4-2
Cytotoxic lymphocytes in delayed drug allergy
!
Jean François Nicolas, Axel Villani, Aurore Rozieres, Osami Kanagawa, Benoit Bensaid, Frédéric Bérard, Audrey Nosbaum,
Marc Vocanson
!
!
INSERM U1111 CIRI, Lyon Sud University Hospital, University Lyon1
Co-sponsored by Consultations of Dermatology in Okayama
JSID-Asia-Oceania-Forum
17:50-18:35
JAOF1
Chair: Ichiro Katayama
Chronic active EB virus infection and hydroa vacciniforme-like skin eruptions
Zigang Xu
Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing
JAOF2
Neurofibromatosis I
Jong-Hee Chae
Department of Pediatrics, Seoul National University, Seoul
JAOF3
Pemphigus: Epidemiology, Clinical Presentation and New Treatments
Chia-Yu Chu
Department of Dermatology, National Taiwan University Hospital, Taipei
- 44 -
(Hair and Cutaneous Development, Immunology 2: Innate Immunity and
Microbiology)
8:55-10:31
Chairs: Manabu Ohyama, Hayato Takahashi
C08-01
[P09-05]
8:55-9:07
Inducing hair follicle organogenesis with defined environmental protein factors
C08-02
[P09-03]
9:07-9:19
Plasmacytoid dendritic cells as a key player in the initiation phase of alopecia areata-induced C3H HeJ mouse
C08-03
[P09-02]
9:19-9:31
BNIP3 PLAYS CRUCIAL ROLES IN THE DIFFERENTIATION AND MAINTENANCE OF EPIDERMAL
KERATINOCYTES
Sabrina Mai-Yi Fan1, Chien-Mei Yen1,2, Su-Hua Pan3, Yu-Ju Chen4,
Sung-Jan Lin1,2
1
University, 3Institute of Genomics and Proteomics, National Taiwan University, 4Institute of Chemistry, Academia Sinica
!
Taisuke Ito, Takahiro Suzuki, Jun-ichi Sakabe, Atsuko Funakoshi, Yoshiki Tokura
Hamamatsu University School of Medicine
Hirokazu Kubo, Mariko Moriyama, Yuka Nakajima, Arisa Goto, Takao Hayakawa, Hiroyuki Moriyama
Pharmaceutical Research and Technology Institute, Kinki University, Osaka, Japan
C08-04
[P09-01]
9:31-9:43
Functional tight junction barriers in sebaceous glands: defects in holocrine secretion in claudin-1 deficient mice
C08-05
[P11-05]
9:43-9:55
Dermokine β γ deficiency enhances imiquimod-induced psoriasis-like inflammation
C08-06
[P11-04]
9:55-10:07
SCF from keratinocyte delivers microbiome signals to skin mast cell
C08-07
[P11-03]
10:07-10:19
Cooperation of IL-1 and IL-36 plays a pivotal role in epicutaneous S.aureus-induced skin inflammation via IL-17
production
Toru Atsugi1,2, Mariko Yokouchi1,3, Ai Hirabayashi4,5, Manabu Ohyama6, Masayuki Amagai1,4,5, Akiharu Kubo1
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Fundamental Research Laboratories, KOSÉ
Corporation, Tokyo, Japan, 3Department of Dermatology, Nerima General Hospital, Tokyo, Japan, 4Laboratory for Skin Homeostasis,
RIKEN Center for Integrative Medicine Sciences, Kanagawa, Japan, 5KOSÉ Endowed Program for Skin Care and Allergy Prevention,
Keio University School of Medicine, Tokyo, Japan, 6Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
!
Atsushi Tokuriki1, Takenao Chino1, Vu H. Luong1, Noritaka Oyama1, Kiyoshi Higashi2, Koichi Saito2, Minoru Hasegawa1
1
Department of Dermatology, University of Fukui, Fukui, Japan, 2Environmental Health Science Laboratory, Sumitomo Chemical Co.,
Ltd., Osaka, Japan
Anna Di Nardo, Zhenping Wang, Nicholas Mascarenhas
Dermatology Department, University of California San Diego
Seitaro Nakagawa1, Yumi Nakamura-Matsuoka1, Yuki Katayama1, Gabriel Nunez2, Hiroyuki Matsue1
1
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, 2Pathology and Comprehensive Cancer
Center, University of Michigan, Ann Arbor, MI, United States
C08-08
[P11-02]
10:19-10:31
Decreased signaling of stem cell factor transforms bone marrow-derived cultured mast cells into M2
macrophage-like cells.
Seiichiro Wakabayashi, Yuumi Nakamura, Hiroyuki Matsue
Dermatology, Chiba University, Chiba, Japan
Luncheon Seminar 5
"Harvesting the fruits of work in dermatological research."
12:20-13:10
LS5-1
Chair: Manabu Ohyama
The regulatory mechanism of Resolvin E1, an omega-3 fatty acids derived lipid mediator, on cutaneous immune
responses
Tetsuya Honda1,2
1
Department of Dermatology, Kyoto University, Kyoto, Japan, 2Department of Innovation Center for Immunoregulation Technologies
and Drugs, Kyoto University Graduate School of Medicine, Kyoto, Japan
LS5-2
The impact of Fli1 deficiency on the immunological aspect of systemic sclerosis
Yoshihide Asano
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Co-sponsored by Mitsubishi Tanabe Pharma Corporation
- 45 -
(Immunology 2: Innate Immunity and Microbiology, Pigmentation and Melanoma)
14:35-16:11
Chairs: Tamio Suzuki, Toshiyuki Yamamoto
C11-01
[P11-07]
14:35-14:47
Role of basophils and eosinophils in the development of pruritus
C11-02
[P11-06]
14:47-14:59
Effects of antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, on human
mast cell functions
Chisa Nakashima, Atsushi Otsuka, Kenji Kabashima
François Niyonsaba1,2, Ko Okumura1, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Faculty of International Liberal
Arts, Juntendo University, Tokyo, Japan
C11-03
[P13-07]
14:59-15:11
Cell division cycle associated gene 1 as a new therapeutic target for melanoma
Aki Tokuzumi, Satoshi Fukushima, Azusa Miyashita, Junji Yamashita, Satoshi Nakahara, Yosuke Kubo, Takamitsu Makino,
Department of Dermatology and Plastic Surgery, Faculty of Life Science, Kumamoto University, Kumamoto, Japan
C11-04
[P13-08]
15:11-15:23
Rhododendrol-induced cytotoxicity to melanocytes is enhanced by UVB exposure
C11-05
[P13-06]
15:23-15:35
Aspirin induces cell death, TRAIL sensitization, and mitochondrial network abnormalities in human melanoma
cells
Noriko Goto1, Taro Masaki1, Hiroshi Nagai1, Shosuke Ito2, Chikako Nishigori1
1
Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan, 2Department of Chemistry, Fujita Health
University School of Health Sciences, Toake, Aichi, Japan
Itsuho Fujikawa1, Miki Suzuki-Karasaki1, Toyoko Ochiai1, Yoshihiro Suzuki-Karasaki2,3
1
Department of Dermatology, Nihon University Hospital, Tokyo, Japan, 2Innovative Therapy Research Group, Nihon University
Research Institute of Medical Science, Tokyo, Japan, 3Division of Physiology, Department of Biomedical Sciences, Nihon University
C11-06
[P13-05]
15:35-15:47
Hair shaft miRNA-221 levels as a new tumor marker of melanoma
Satoshi Fukushima, Taisuke Inada, Masayuki Murai, Masatoshi Jinnin, Azusa Miyashita, Satoshi Nakahara, Aki Tokuzumi,
Hironobu Ihn
C11-07
[P13-04]
15:47-15:59
IFN-β modulates chemokines from tumor-associated macrophages to enhance the therapeutic effect of anti-PD-1
antibodies in B16F10 melanoma
Aya Kakizaki1, Taku Fujimura1, Sadanori Furudate1, Yumi Kambayashi1, Takeshi Yamauchi1, Hideo Yagita2, Setsuya Aiba1
1
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Department of Immunology, Juntendo
C11-08
[P13-03]
15:59-16:11
TLR3 agonist Poly (I : C) enhance Rab27A and melanosome transportation through TLR3 and MAVS pathway in
human epidermal melanocytes
Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Mai Inoue, Kenichiro Tsuchiyama, Setsuya Aiba
Sweets Seminar 5
17:00-17:45
SS5
Chair: Michihiro Hide
Recent advances in skin immunity in the perspective of obesity and antibody distribution
Kenji Kabashima
Co-sponsored by GlaxoSmithKline K.K.
- 46 -
(Carcinogenesis Growth Factors Signal Transduction Cancer Genetics,
Cell Adhesion Matrix Vascular Biology)
!
! !
!
!
8:55-10:31
C09-01
[P02-07]
8:55-9:07
Chairs: Koji Sayama, Masatoshi Jinnin, Minoru Hasegawa
Identification of CD44 transcripts that segregate with proliferation, redox and differentiation activities in human
epidermal keratinocytes
Kwesi Teye1, Sanae Numata1, Norito Ishii1, Rafal_P Krol1, Takahiro Hamada1, Hiroshi Koga1, Daisuke Tsuruta2, Hideyuki Saya3,
Marek Haftek4, Takashi Hashimoto1
1
Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology,
Kurume, Japan, 2Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, 3Division of Gene
Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan, 4University of Lyon 1, EA
4169 and CNRS, Lyon, France
C09-02
[P02-05]
9:07-9:19
Quercetin is a possible agent for combination therapy with vorinostat
C09-03
[P02-03]
9:19-9:31
Sphingosine-1-phosphate stimulating CAMP overexpression accelerates development of cutaneous SCC through
FPRL1 activation
Kazuyasu Fujii, Miho Hatanaka, Atsuko Ibusuki, Takuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences
Kyungho Park1, Young-Il Kim1, Anna Nielsen-Scotta1, Kyong-Oh Shin2, Carine Mainzer1, Yong-Moon Lee2, Walter M. Holleran1,
Sarah Arron1, Theodora M. Mauro1, Peter M. Elias1, Yoshikazu Uchida1
1
Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, 2College of Pharmacy
Chungbuk National University, Cheongju, South Korea
C09-04
[P02-02]
9:31-9:43
The significance of over-expression both of NUAK2 and of phospho-Akt (S473) on patient’s survival of acral
melanomas
Takeshi Namiki1,2,3, Tomonori Yaguchi1, Kenta Nakamura1,4, Masakazu Kawaguchi3, Atsushi Tanemura5, Ichiro Katayama5,
Hiroo Yokozeki2, Yutaka Kawakami1, Vincent J Hearing3
1
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, 2Department of
Dermatology, Tokyo Medical and Dental University, 3Laboratory of Cell Biology, National Cancer Institute, National Institutes of
Health, 4Department of Dermatology, Shinshu University, 5Department of Dermatology, Osaka University
C09-05
[P03-05]
9:43-9:55
Mechanistic Insight into the Norepinephrine-induced Fibrosis in Systemic Sclerosis
Akihito Uehara, Kazuya Yamada, Akihiko Uchiyama, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi,
Osamu Ishikawa, Sei-ichiro Motegi
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
C09-06
[P03-04]
9:55-10:07
!
DJM-1 cells deficient in BP180 Type XVII collagen exhibit rudiment hemidesmosomes and abnormal pattern of
laminin-332 matrix
Yoshiaki Hirako, Ryotaro Kamo, Minori Kaneda
Division of Biological Science, Graduate School of Science, Nagoya University, Aichi, Japan
C09-07
[P03-03]
10:07-10:19
Classical cadherins control polarized organization of junctions and cytoskeleton in stratified epithelia
Matthias Ruebsam1, Akiharu Kubo2, Aaron Mertz3, Barbara Boggetti1, Gladiola Goranci1, Eric Dufresne3, Valerie Horsley3,
Masayuki Amagai2, Carien M. Niessen1
1
Department of Dermatology, University of Cologne, Cologne, Germany, 2Department of Dermatology, Keio University School of
Medicine, Tokyo, Japan, 3Yale University, New Haven, CT, USA
C09-08
[P03-02]
10:19-10:31
Inhibitory regulation of apelin on fibrosis in systemic sclerosis
Yoko Yokoyama, Sachiko Ogino, Akihiko Uchiyama, Kazuya Yamada, Akihito Uehara, Osamu Ishikawa, Sei-ichiro Motegi
- 47 -
Luncheon Seminar 6
"The Key Pathogenic Players for Psoriasis Vulgaris―From Immunological
Viewpoint"
12:20-13:10
LS6-1
Chair: Akimichi Morita
Nucleic Acid Recognition by Toll-like Receptors
Kensuke Miyake1,2,3
1
Division of Innate Immunity, Department of Microbiology and Immunology, 2Laboratory of Innate Immunity, Center for Experimental
Medicine and Systems Biology, 3The Institute of Medical Science, The University of Tokyo
LS6-2
!
Calcipotriol and betamethasone dipropionate show additive inhibitory effects on TNFα and IL-23 Th17 immune
axis in psoriasis
Paola Lovato
!
LEO Pharma A S
!
Co-sponsored by LEO Pharma K.K. Kyowa Hakko Kirin Co., Ltd.
(Human Clinical Research and Therapeutics, Epidermal Structure and Function)
14:35-16:11
Chairs: Yuping Ran, Hideo Asada, Ryuhei Okuyama
C12-01
[P04-08]
14:35-14:47
Induction of S100 calcium-binding protein A2 expression in keratinocytes by telaprevir and trichloroethylene
C12-02
[P04-09]
14:47-14:59
Bath-PUVA therapy improves impaired resting regulatory T cells and increases circulating activated regulatory T
cells in psoriasis.
Manabu Yoshioka, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Yu Sawada, Daisuke Nisio, Motonobu Nakamura
University of Occupational and Environmental Health, Japan
Ryoji Kubo1, Shinnosuke Muramatsu1, Yoko Sagawa1, Chiyo Saito1, Saori Kasuya1, Akiko Nishioka1, Emi Nishida1,
Sayuri Yamazaki2, Akimichi Morita1
1
Japan, 2Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
C12-03
[P04-06]
14:59-15:11
Distinct lymphocyte subsets responsible for classical and systemic hydroa vacciniforme
Tomoko Miyake1, Yoji Hirai1, Takenobu Yamamoto1,2, Masahide Imada1, Shin Morizane1, Toshihisa Hamada1, Hiroshi Kimura3,
Keiji Iwatsuki1
1
2
C12-04
[P04-05]
15:11-15:23
Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences,
Departments of Dermatology, Kawasaki Medical College, 3Departments of Dermatology, Nagoya University School of Medicine
!
Presence of anti-β2GP1 HLA-DR complex autoantibodies in the non-APS patients with recurrent limb
ulcerations
Noriko Arase1,2, Kenji Tanimura2,3, Jin Hui2, Sumiko Matsuoka2, Toshifumi Yamaoka1, Megumi Nishioka1, Eiji Kiyohara1,
Mamori Tani1, Koichiro Ohmura4, Hiroyuki Murota1, Hisashi Arase2,5, Ichiro Katayama1
Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan, 2Department of Immunochemistry,
Research Institute for Microbial Diseases, Osaka University, 3Department of Obstetrics and Gynecology, Graduate School of
Medicine, Kobe University, 4Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University,
5
Immunochemistry, Immunology Frontier Research Center, Osaka University
1
C12-05
[P04-04]
15:23-15:35
Preferential expression of CD134, HHV-6 cellular receptor, on CD4 T cells in drug-induced hypersensitivity
syndrome
Fumi Miyagawa, Yuki Nakamura, Hideo Asada
Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan
C12-06
[P05-06]
15:35-15:47
Initiation of cornification is regulated by Ca2+ and pH in isolated mouse stratum granulosum cells
C12-07
[P05-05]
15:47-15:59
Decreased filaggrin level leads to sweat duct obstruction, a possible underlying mechanism of reduced sweating
in atopic dermatitis
Takeshi Matsui1, Yuki Furuichi1,2, Ai Hirabayashi2,3, Masayuki Amagai1,2
1
Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 2Department of Dermatology,
Keio University School of Medicine, 3KOSÉ Endowed Program for Skin Care and Allergy Prevention, Keio University School of
Medicine
Pawinee Rerknimitr1,2,3, Hideaki Tanizaki1, Atsushi Otsuka1, Yoshiki Miyachi1, Kenji Kabashima1
1
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Division of Dermatology, Department of
Medicine, Faculty of Medicine, Allergy and Clinical Immunology Research Group, Chulalongkorn University, Bangkok, Thailand,
3
Dermatology Unit, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
- 48 -
C12-08
[P05-03]
15:59-16:11
!
!
The Nrf2 Keap1 pathway contributes to the pathogenesis of atopic dermatitis by directly regulating the IL33 ST2
pathway in the epidermis
Yosuke Ishitsuka, Dennis Roop
Department of Dermatology Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado
Anschutz Medical Campus
Sweets Seminar 6
"Treatment Strategy for Psoriasis with Comorbidities Taken into Account"
17:00-17:45
SS6-1
Chair: Wataru Fujimoto
―The Biologics Era Chapter 2―Focusing on Comorbidities and Prognosis of Psoriasis
Yayoi Tada
Department of Dermatology, University of Teikyo, Tokyo, Japan
SS6-2
Advances in the Managements of Psoriatic Arthritis: A Rheumatologist’s viewpoint
Masahiro Yamamura
Center for Rheumatology, Okayama Saiseikai General Hospital
!
Co-sponsored by AbbVie GK Eisai Co., Ltd.
- 49 -
Morning Seminar 2
"Pustular psoriasis: how pustules develop？―Considerations with special
reference to genetic backgrounds and therapeutic responses―"
8:00-8:50
MS2-1
Chair: Shigaku Ikeda
Genetic background of pustular psoriasis
Kazumitsu Sugiura
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya Japan
MS2-2
A new therapy for generalized pustular psoriasis: Granulocyte and Monocyte Adsorption Apheresis
Takuro Kanekura
Co-sponsored by JIMRO Co., Ltd.
International Symposium on Intractable Skin Diseases:
Current Advances and Medical Innovations
9:00-12:35
"Ministry of Health, Labour and Welfare
Research Initiative on Overcoming Intractable Skin Diseases"
9:00-9:45
Chair: Masayuki Amagai
"Research team on rare and intractable skin diseases"
ISY1-1
Activities of the research team for rare and intractable skin diseases
Masayuki Amagai
Department of Dermatology, Keio University School of Medicine
Principal Investigator of rare and intractable skin diseases
ISY1-2
Inherited epidermolysis bullosa: the international consensus classification
Giovanna Zambruno
Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata, IRCCS, Rome
9:50-10:35
Chair: Chikako Nishigori
"Establishing evidence-based clinical guidelines for interdepartmental
investigations of neurocutaneous syndrome"
ISY2-1
!
Establishing evidence based clinical guidelines for interdepartmental investigations of neurocutaneous
syndromes
Chikako Nishigori
Department of Dermatology, Graduate School of Medicine, Kobe University
Principal Investigator of neurocutaneous syndromes
ISY2-2
Targeted Gene Correction in DNA Repair-Deficient XERODERMA PIGMENTOSUM Skin Cells
Alain Sarasin, Aurélie Dupuy
!
Laboratory of genetic instability and oncogenesis, UMR8200 CNRS, Gustave Roussy Institute, University Paris Sud, Villejuif
"Coffee Break"
10:35-10:50
- 50 -
"Special Lecture"
10:50-11:35
SL
Chair: Hironobu Ihn
New strategies for targeting fibrosis in systemic sclerosis
Maria Trojanowska
Arthritis Center, Boston University School of Medicine, Boston
"Latest medical developments in intractable skin diseases"
11:40-12:00
Chairs: Masayuki Amagai, Chikako Nishigori
"ASDR exchange program"
ISY3-1
High risk squamous cell carcinoma in recessive dystrophic epidermolysis bullosa and the role of a permissive
tumor microenvironment
Dedee F. Murrell1,2
1
Dept of Dermatology, St George Hospital, University of New South Wales, Sydney, 2Australasian Society for Dermatological
Research
12:05-12:35
"Panel discussion"
ISY3-2
Mesenchymal cell therapy for recessive dystrophic epidermolysis bullosa
Katsuto Tamai, Yasushi Kikuchi, Yasufumi Kaneda, Ichiro Katayama
Osaka University Graduate School of Medicine, Suita, Osaka
ISY3-3
Topical rapamycin formulation for tuberous sclerosis complex
!
Mari Wataya Kaneda
Department of Dermatology, Graduate School of Medicine, Osaka University
ISY3-4
In vitro study of read-through therapy for pseudoxanthoma elasticum
Yumi Okubo1, Yuka Nakazawa2,3, Tomoo Ogi2,4, Michinori Matsuo5, Keisuke Hamada6, Akihiro Taguchi6, Kentaro Takayama6,
Yoshio Hayashi6, Akira Iwanaga1, Atsushi Utani1
1
Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, 2Nagasaki University Research Centre
for Genomic Instability and Carcinogenesis (NRGIC), 3Department of Genome Repair, Atomic Bomb Disease Institute, Nagasaki
University, 4Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, 5Department of Food
and Nutrition, Faculty of Home Economics, Kyoto Women’s University, 6Department of Medicinal Chemistry, School of Pharmacy,
Tokyo University of Pharmacy and Life Sciences
ISY3-5
Establishment and characterization of iPS cells derived from XPA patients
Chihiro Shimizuhira1, Hidaka Yokota1,2, Atsushi Otsuka1, Yumi Nonomura1, Shinichi Moriwaki3, Yoshinori Yoshida2,
Yoshiki Miyachi1, Shinya Yamanaka2, Kenji Kabashima1
1
Department of Dermatology, Graduate School of Medicine, Kyoto University, 2Department of Reprogramming Science, Center for
iPS Cell Research and Application, Kyoto University, 3Department of Dermatology, Osaka Medical College
Luncheon Seminar 7
12:40-13:30
LS7-1
Chair: Shigetoshi Sano
Crucial role of the tissue structure for stratum corneum permeability
Marek Haftek
Laboratory for Dermatological Research, EA4169 “Fundamental, Clinical and Therapeutic Aspects of the Skin Barrier Function”
Faculté de Médecine et de Pharmacie, Université Lyon 1, Lyon, France
LS7-2
New Insights into the Pathogenesis of Atopic Dermatitis
Peter M. Elias
Dermatology Service, VA Medical Center and Department of Dermatology, UCSF, San Francisco, CA, USA
LS7-3
! ! !
Two bird one stone solution on atopic dermatitis treatment
Hyunjung Kim
Department of Dermatology, Seoul Metropolitan Medical Center, Seoul, Korea
Co-sponsored by Consultations of Dermatology in Okayama & SOMREK
- 51 -
December 11-12, 2015, Poster Venue
Poster Presentation
Category 1 (P01): Autoimmunity Inflammation
!
P01-01
[II-1]
The impact of Fli1 deficiency in B cells on the development of systemic sclerosis.
Ryosuke Saigusa1, Yoshihide Asano1, Kouki Nakamura1, Shunsuke Miura1, Takashi Yamashita1, Yohei Ichimura1,
Takehiro Takahashi1, Tetsuo Toyama1, Takashi Taniguchi1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
School of Medicine, Boston, Massachusetts
P01-02
[III-5]
Am80 ameliorates fibrosis, inflammation, and vasculopathy in animal models of systemic sclerosis
Tetsuo Toyama1,2, Yoshihide Asano1, Kouki Nakamura1, Takashi Yamashita1, Ryosuke Saigusa1, Takehiro Takahashi1,
Yohei Ichimura1, Takashi Taniguchi1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
School of Medicine
P01-03
[I-4]
Anti-desmoglein 3 IgG production is reduced by intravenous immunoglobulin in B220- antibody-secreting cells in
mice with pemphigus vulgaris
Yuko Kase1,2, Jun Yamagami1, Naoko Wada1, Hayato Takahashi1, Shigeo Koyasu3,4, Masayuki Amagai1,3
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Central Research Laboratory, Japan Blood Products
Organization, 3RIKEN Center for Integrative Medical Sciences, 4Department of Microbiology and Immunology, Keio University School
of Medicine
P01-04
[I-2]
Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD
8 epitope peptide
Naoko Okiyama1,2,3,4, Hisanori Hasegawa1, Takatoku Oida3, Shinya Hirata1, Hiroo Yokozeki2, Manabu Fujimoto4, Hitoshi Kohsaka1,3
1
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo,
Japan, 2Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo,
Japan, 3Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan, 4Department of Dermatology,
Faculty of Medicine, University of Tokyo, Ibaraki, Japan
P01-05
[C07-03]
Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid
Kentaro Izumi, Wataru Nishie, Yosuke Mai, Mayumi Wada, Ken Natsuga, Hideyuki Ujiie, Hiroaki Iwata, Hiroshi Shimizu
P01-06
[C07-04]
Lymph node stromal cell-mediated deletional tolerance controls the development of GVHD-like skin lesion in
involucrin-mOVA mice
Yujin Nakagawa1, Gyohei Egawa1, Tetsuya Honda1, Jun-ichi Sakabe2, Kenji Kabashima1
1
Department of Dermatology, Kyoto University Graduate School of Medicine, 2Agency for Science, Technology and Research,
Singapore
P01-07
[C07-02]
Vitamin D analogue MC903 improves imiquimod-induced psoriatic skin lesion via directly inhibiting IL-23
production by Langerhans cells
Nobuhiro Kusuba, Akihiko Kitoh, Kenji Kabashima
P01-08
[C07-01]
The role of purinergic signaling in development of irritant dermatitis of acrodermatitis enteropathica
Youichi Ogawa, Tatsuyoshi Kawamura, Takamitsu Matsuzawa, Rui Aoki, Shinji Shimada
Dermatology, University of Yamanashi
P01-09
[C10-07]
!
Recruitment, activation and function of monocytes macrophage in skin wound healing
Sebastian Willenborg1, Nhu-Nguyen Do1, Xiaolei Ding1, Geert van Loo2, Manolis Pasparakis3,4,5, Sabine A. Eming1,4,5
1
Department of Dermatology, University of Cologne, Cologne, Germany, 2Department for Molecular Biomedical Research, VIB and
Department of Biomedical Molecular Biology, Ghent University, Belgium, 3Institute for Genetics, University of Cologne, Cologne,
Germany, 4Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, 5Cologne Excellence Cluster on
Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany
P01-10
[C10-08]
Upregulation of interleukin-33 receptor expression on basophils in human atopic dermatitis; interaction of
scratching and IL-33 production
Yumi Nonomura, Atsushi Otsuka, Chisa Nakashima, Kenji Kabashima
P01-11
[O1-13]
Analysis of domain structure-function relationship in NOD-like receptor family members
Junichiro Hiruma1,2, Masashi Miyai1, Mami Yamamoto-Tanaka1,2, Ryoji Tsuboi2, Toshihiko Hibino1
1
Shiseido Research Center, Yokohama, Japan, 2Department of Dermatology, Tokyo Medical University, Tokyo, Japan
- 52 -
P01-12
[C10-06]
!
Regnase-1 of the epidermis plays a regulatory role in inflammatory response to irritative innate stimuli, but not
to contact allergy.
Mikiro Takaishi1, Takashi Satoh2, Shizuo Akira2, Shigetoshi Sano1
1
Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan, 2Department of Host Defense, Research
Institute for Microbial Diseases, Osaka University, Suita, Japan
P01-13
[O1-14]
Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice
Noriko Ando1, Yuki Nakamura2, Rui Aoki1, Kayoko Ishimaru2, Shinji Shimada1, Atsuhito Nakao2
1
Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Immunology, University of Yamanashi,
Yamanashi, Japan
P01-14
[O1-15]
Bone marrow-derived clonal mesenchymal stem cells inhibit NK- and T-cell infiltration and reduce alopecia
areata in mouse model
Ji Won Byun1, Hyo Jin Kim1, Kwangmin Na2, Sun Uk Song2, Myung Shin Jeon2, Gwang Seong Choi1
1
The Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea, 2Translational Research Center,
Inha University School of Medicine, Incheon, Republic of Korea
P01-15
[C10-05]
Leptin may enhance IL-6 production via decreased expression of caveolin-1 in human keratinocytes
Yuko Watanabe, Yukie Yamaguchi, Noriko Komitsu, Michiko Aihara
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
P01-16
[C10-04]
Activation of p38 MAPK mediates the induction of murine psoriatic dermatitis
Kenji Sakurai, Teruki Dainichi, Reiko Matsumoto, Yuri Nakano, Kenji Kabashima
P01-17
[C10-03]
The antifibrotic effect of α2AP neutralization in systemic sclerosis dermal fibroblasts and mouse models of
systemic sclerosis
Yosuke Kanno1, En Shu2, Hiroyuki Kanoh2, Mariko Seishima2
1
P01-18
[C10-02]
Doshisha Women’s Collage of Liberal Arts, 2Gifu University Graduate School of Medicine
!
Monocyte-derived IP-10 has a major role in the pathogenesis of sustained progressing phenotypes in NakajoNishimura syndrome
Nobuo Kanazawa1, Yumi Nakatani1, Yutaka Inaba1, Kayo Kunimoto1, Fukumi Furukawa1, Fumiko Ozaki2
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Center for iPS Cell Research and Application,
Kyoto University, Kyoto, Japan
P01-19
[C10-01]
Impaired expression of the antimicrobial protein REG3A exacerbates TLR3-mediated inflammation in diabetic
skin wounds
Yelin Wu1, Yuanqi Liu1, Yanchun Quan1, Keiwei Liu1, Hongquan Li1, Ziwei Jiang1, Tian Zhang1, Hu Lei1, Katherine Radek2,
Dongqing Li1, Zhenhua Wang1, Jilong Lu1, Zhaofan Xia3, Yuping Lai1
1
School of Life Sciences, East China Normal University, Shanghai, China, 2Department of Surgery, Burn and Shock Trauma Research
Institute, Loyola University Chicago, Health Sciences Campus, Maywood, 3Burn Institute of Chinese PLA and Department of Burn
Surgery, Changhai Hospital, Second Military Medical University, Shanghai
P01-20
[C04-06]
Inflammatory skin march: a concept for IL-1 mediated skin inflammation to cardio-vascular events including
atopic dermatitis and psoriasis
Keiichi Yamanaka, Hitoshi Mizutani
Department of Dermatology, Mie University, Mie, Japan
P01-21
[C04-04]
Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody
production and disease activity
Takashi Matsushita1, Yasuhito Hamaguchi1, Minoru Hasegawa2, Manabu Fujimoto3, Kazuhiko Takehara1
1
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,
2
Department of Dermatology, University of Fukui, 3Department of Dermatology, Faculty of Medicine, University of Tsukuba
P01-22
[C04-05]
CRH is a stimulator for mucosal-type mast cell degranulation and proliferation
Yukari Mizukami1, Koji Sugawara1, Ralf Paus2, Daisuke Tsuruta1
1
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, 2Centre for Dermatology, Institute of
Inflammation and Repair, University of Manchester, Manchester, UK
P01-23
[C04-02]
Characterization of the population like follicular helper T cells in the peripheral blood in patients with pemphigus
Jun Yamagami, Aki Kamata, Masayuki Amagai
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
P01-24
[C04-03]
Interleukin-17A plays a fundamental role in the expression of psoriasis signature genes in keratinocytes through
the induction of IκB-ζ
Ryuta Muromoto, Toru Hirao, Keisuke Tawa, Tadashi Matsuda
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
- 53 -
P01-25
[C04-01]
Kinetic of two distinct diseases induced by topical treatment with imiquimod cream in mice: skin inflammation
and systemic autoimmunity
Sayo Kataoka, Mayuko Yamamoto, Kentaro Ohko, Reiko Kamijima, Chisa Matsuoka, Shigetoshi Sano
P01-26
[O1-16]
Exosome expression in the skin and sera of systemic sclerosis patients, and its possible therapeutic application
against skin ulcer
Kayo Nakamura, Masatoshi Jinnin, Satoshi Fukushima, Hironobu Ihn
P01-27
[O1-17]
NOD2 inflammasome is up-regulated in the skin with atopic dermatitis.
Masashi Miyai1, Mami Yamamoto-Tanaka1,3, Mika Sawane1, Haruyo Yamanishi1, Masakiyo Sakaguchi2, Ryoji Tsuboi3,
Toshihiko Hibino1
1
Shiseido Research Center, Yokohama, 2Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry
and Pharmaceutical Sciences, Okayama, 3Department of Dermatology, Tokyo Medical University, Tokyo, Japan
P01-28
[O1-18]
Cathelicidin peptide LL-37 induces UVB-triggered inflammasome activation and angiogenesis: Possible
implications for rosacea
Yoji Hirai1, Sonja Kresse2, Suzanna Salzer2, Shin Morizane1, Keiji Iwatsuki1, Thomas Ruzicka2, Juergen Schauber2
1
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama,
Japan, 2Department of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany
P01-29
[O1-19]
KLK6 is required for imiquimod-induced psoriasiform skin inflammation in mice
Shin Iinuma1, Mari Kishibe1, Nao Saito1, Satomi Igawa1, Masaru Honma1, Yoshio Bando2, Shigetaka Yoshida2,
Akemi Ishida-Yamamoto1
1
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan, 2Department of Functional Anatomy and
Neuroscience, Asahikawa Medical University, Asahikawa, Japan
P01-30
[O1-20]
Mechanism of S100A9 induction in the skin with atopic dermatitis―involvement of NOD2 inflammasome
activation―
Mami Yamamoto-Tanaka1,2, Masashi Miyai1, Mika Sawane1, Haruyo Yamanishi1, Masakiyo Sakaguchi3, Ryoji Tsuboi2,
Toshihiko Hibino1
1
Shiseido Research Center, Yokohama, Japan, 2Department of Dermatology, Tokyo Medical University, Tokyo, Japan, 3Department of
Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
P01-31
[O1-21]
IL-1 and IL-36 are the dominant cytokines in Palmar Plantar Pustulosis
Andrew Johnston1, Xianying Xing1, Liza Wolterink1, Drew H. Barnes1, J. Michelle Kahlenberg3, Paul W. Harms2,
Johann E. Gudjonsson1
1
Dermatology, University of MIchigan, Ann Arbor, MI, USA, 2Department of Pathology, University of MIchigan, Ann Arbor, Michigan,
USA, 3Department of Rheumatology, University of MIchigan, Ann Arbor, Michigan, USA
P01-32
[O1-22]
Platelets contribute to leukocyte recruitment to skin in allergic and irritant contact dermatitis
Risa Tamagawa-Mineoka, Risa Yasuike, Eri Hotta, Hiromi Mizutani, Naomi Nakamura, Norito Katoh
Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
P01-33
[O1-23]
!
Prostaglandin E receptor4 inhibition restores UVB-induced downregulation of ATP2A2 SERCA2 in cultures
Maya Kamijo1, Akino Wada1, Reiko Mineki2, Tamami Sakanishi3, Shigaku Ikeda1
1
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2Laboratory of Proteomics and
Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, 3Division of Cell Biology,
Research Support Center, Juntendo University Graduate School of Medicine
P01-34
[O1-24]
Subcutaneous presensitization to protease antigen and IL-33-dependent airway responses cooperatively
contribute to airway inflammation
Hirono Ochi1,2, Toshiro Takai2, Seiji Kamijo2, Sakiko Shimura2, Natsuko Maruyama1,2, Akira Matsuda3, Hirohisa Saito2,4,
Susumu Nakae2,5, Ko Okumura2, Hideoki Ogawa1,2, Shigaku Ikeda1,2
1
Research Center, Juntendo University Graduate School of Medicine, 3Department of Ophthalmology, Juntendo University Graduate
School of Medicine, 4Department of Allergy and Immunology, National Research Institute for Child Health and Development, 5The
Institute of Medical Science, The University of Tokyo
P01-35
[O1-25]
Analysis of the ROS production in neutrophils of Nakajo-Nishimura syndrome patients
Kayo Kunimoto1, Fumiko Ozaki2, Fukumi Furukawa1, Nobuo Kanazawa1
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Center for iPS Cell research and Application, Kyoto
University
P01-36
[O1-26]
Serum levels of various anti-Fcγ receptor antibodies in patients with systemic sclerosis
Takafumi Kadono1, Manabu Tomita2, Yoshihide Asano2, Shinichi Sato2
1
Department of Dermatology, St. Marianna University, School of Medicine, Kawasaki, Japan, 2Department of Dermatology, The
University of Tokyo, Tokyo, Japan
- 54 -
P01-37
[O1-27]
Increased Expression of CXCR3 and its Ligands in Vitiligo Patients and its Role as Potential Clinical Markers for
Vitiligo
Xiuxiu Wang, Leihong Xiang
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China
P01-38
[O1-28]
Electrophysiological characterization of BNP- and GRP-responsive dorsal horn neurons in spinal itch
transmission
Mitsutoshi Tominaga1, Fumiya Kusube1,2, Hiroaki Kawasaki1, Fumiyuki Yamakura3, Hisashi Naito4, Hideoki Ogawa1,
Yasuhiro Tomooka2, Kenji Takamori1,5
1
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2Department of
Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 3Juntendo University
Faculty of International Liberal Arts, 4Institute of Health and Sports Science & Medicine, Juntendo University, 5Department of
Dermatology, Juntendo University Urayasu Hospital
P01-39
[O1-29]
Glycyrrhizin ameliorates fibrosis, vasculopathy, and immune abnormalities in animal models of systemic sclerosis
Takashi Yamashita1, Yoshihide Asano1, Takashi Taniguchi1, Ryosuke Saigusa1, Kouki Nakamura1, Shunsuke Miura1,
Tetsuo Toyama1, Takehiro Takahashi1, Yohei Ichimura1, Ayumi Yoshizaki1, Maria Trojanowska2, Shinichi Sato1
1
P01-40
[O1-30]
University of Tokyo Graduate School of Medicine, 2Arthritis Center, Boston University School of Medicine
Keratin1, keratin10, desmoglein1 and desmocollin1 expressions are downregulated in the lesional epidermal
keratinocytes of atopic dermatitis
Ami Totsuka1, Miyuki Omori-Miyake2, Yuichiro Tsunemi1, Junji Yagi2, Makoto Kawashima1
1
Department of Dermatology, Tokyo Women’s Medical University, Tokyo, Japan, 2Department of Microbiology and Immunology,
Tokyo Women’s Medical University, Tokyo, Japan
P01-41
[O1-31]
Key immune modulatory effects exerted by combination of calcipotriol and corticosteroid on psoriasis
inflammation
Paola Lovato1, Hanne Norsgaard1, Mads Røpke2
1
P01-42
[O1-32]
Skin Research, LEO Pharma, Denmark, 2Clinical Pharmacology, LEO Pharma, Denmark
Glycolic acid silences inflammasome complex genes by inducing DNA methylation in HaCaT cells
Jen-Hung Yang1, Sheau-Chung Tang1,2, Jih-I Yeh1,3, Sung-Jen Hung1, Yu-Ping Hsiao4, Fu-Tong Liu2,5
1
1. Department of Dermatology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 2. Department of Biochemistry, Tzu Chi
University; 3. Institute of Medicine, Tzu Chi University, Hualien, Taiwan, 2Institute of Biomedical Sciences, Academia Sinica, Taipei,
Taiwan, 3Department of Family Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, 4Department of Dermatology, Chung
Shan Medical University Hospital, Taichung, Taiwan, 5Department of Dermatology, University of California Davis School of
Medicine, Sacramento, California, USA
P01-43
[O1-33]
Increase of psoriasis-associated IL-8 in the intralesional blood despite undetectable in the peripheral blood
Tatsushi Ishimoto, Saho Kataoka, Takeo Shiga, Shigetoshi Sano
P01-44
[O1-34]
Decreased expression of ELOVL and ceramide synthase in dermatitis caused by repeated exposure to house-dust
mite in NC Nga mice
!
Hiroyuki Kanoh1, Asako Ishitsuka1, Etsuko Fujine1, Shuhei Matsuhaba2, Mitsuhiro Nakamura3, Naoki Inagaki2, Yoshiko Banno1,
Mariko Seishima1
1
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 2Laboratory of Pharmacology, Gifu
Pharmaceutical University, Gifu, Japan, 3Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan
P01-45
[O1-35]
Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis
Kanako Matsuyama1, Yoko Mizutani1, En Shu1, Hiroyuki Kanoh1, Tatsuhiko Miyazaki2, Mariko Seishima1
1
The department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 2the division of Pathology, Gifu
University Hospital
P01-46
[O1-36]
Autoantibody profile and clinical manifestations related to anti-synthetase syndrome
Hiroko Fukamatsu1, Yoji Hirai1, Tomoko Miyake1, Tatsuya Kaji1, Toshihisa Hamada1, Seiichiro Norikane2, Keiji Iwatsuki1
1
P01-47
[O1-37]
Department of Dermatology, Okayama University Hospital, 2Department of Radiology, Okayama University Hospital
Usefulness of flow cytometric analysis for detection of anti-FcεRIα autoantibody in chronic spontaneous urticaria
Satoshi Izaki1,2, Satoshi Nunomura1,2, Koremasa Hayama1,2, Daisuke Fujisawa1,2, Yuko Hatada1,2, Hideki Fujita1, Chisei Ra2,
Yoshimichi Okayama2, Tadashi Terui1
1
Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan, 2Allergy and
Immunology Group, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan
P01-48
[O1-38]
Increased levels of high mobility group box-1 in the serum and skin in patients with generalized pustular psoriasis
Tomoya Watanabe, Yukie Yamaguchi, Noriko Komitsu, Naoko Takamura, Yuko Watanabe, Michiko Aihara
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
- 55 -
P01-49
[O1-39]
Association of urinary biopyrrin with disease activity of atopic dermatitis in adults
Sayaka Shibama1,2, Tsukasa Ugajin1, Tokio Yamaguchi3, Hiroo Yokozeki1
1
Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 2Department of Dermatology, Sakura Hospital,
Medical Center, Toho University, 3Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental
University
P01-50
[O1-40]
Gnaphalium affine D. Don inhibits the inflammatory response by suppressing the MAPK-mediated transcriptional
activation in RAW264.7 cells.
Kyung-Baeg Roh1, Jung-A Lee1, Junho Park2, Kwangseon Jung2, Eunsun Jung1, Deokhoon Park1
1
P01-51
[O1-41]
Biospectrum Life Science Institute, seongnam, Korea, 2SkinCure Inc., seongnam, Korea
Elevated serum YKL-40 in patients with Behcet’s disease
Do-Young Kim1,2, Yuri Ahn1, Zhenlong Zheng1, Dae Suk Kim1, Min Ju Choi1, Dongsik Bang2
1
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea,
2
Department of Dermatology, Catholic Kwandong University, International St. Mary´s Hospital, Incheon, Korea
P01-52
[O1-42]
The evaluation of B10 cells in the patients with autoimmune blistering diseases
Miho Kabuto, Noriki Fujimoto, Toshifumi Takahashi, Toshihiro Tanaka
Department of Dermatology, Shiga University of Medical Science, Shiga, Japan
P01-53
[O1-43]
Expression of phosphatidylglucoside in human skin disorders atopic dermatitis and psoriasis
Roudy C. Ekyalongo1, Noriko Yokoyama1, Katsunari Kina1, Hitoshi Nakayama1, Mitsuaki Tominaga1, Hideoki Ogawa1,
Kenji Takamori1,2, Yasushi Suga2, Yoshio Hirabayashi1,3, Kazuhisa Iwabuchi1,4
1
Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, 2Department of
Dermatology, Juntendo University Urayasu Hospital, 3Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science
Institute, 4Infection Control Nursing, Juntendo University Graduate School of Health Care and Nursing
P01-54
[O1-44]
A possible example of an inverse intramolecular epitope-spreading phenomenon in bullous pemphigoid
associated with psoriasis
Naoki Oiso1, Kazunori Okahashi1, Norito Ishii2, Shusuke Uchida1, Hiromasa Matsuda1, Takashi Hashimoto2, Akira Kawada1
1
Department of Dermatology, Kinki University Faculty of Medicine, 2Department of Dermatology, Kurume University School of
Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan
!
!
!
Category 2 (P02): Carcinogenesis Growth Factors Signal Transduction Cancer
Genetics
P02-01
[III-4]
Artemin-administered mice develop thermohyperesthesia of skin via central sensitization to heat
Hiroyuki Murota1, Yuki Mori2, Yoshichika Yoshioka2, Ichiro Katayama1
1
Depatment of Dermatology, Osaka University, Osaka, Japan, 2Biofunctional Imaging, Immunology Frontier Research Center, Osaka
University, Osaka, Japan
P02-02
[C09-04]
The significance of over-expression both of NUAK2 and of phospho-Akt (S473) on patient’s survival of acral
melanomas
Takeshi Namiki1,2,3, Tomonori Yaguchi1, Kenta Nakamura1,4, Masakazu Kawaguchi3, Atsushi Tanemura5, Ichiro Katayama5,
Hiroo Yokozeki2, Yutaka Kawakami1, Vincent J Hearing3
1
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, 2Department of
Dermatology, Tokyo Medical and Dental University, 3Laboratory of Cell Biology, National Cancer Institute, National Institutes of
Health, 4Department of Dermatology, Shinshu University, 5Department of Dermatology, Osaka University
P02-03
[C09-03]
Sphingosine-1-phosphate stimulating CAMP overexpression accelerates development of cutaneous SCC through
FPRL1 activation
Kyungho Park1, Young-Il Kim1, Anna Nielsen-Scotta1, Kyong-Oh Shin2, Carine Mainzer1, Yong-Moon Lee2, Walter M. Holleran1,
Sarah Arron1, Theodora M. Mauro1, Peter M. Elias1, Yoshikazu Uchida1
1
Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, 2College of Pharmacy
Chungbuk National University, Cheongju, South Korea
P02-04
[O3-24]
Effects of macrophage migration inhibitory factor on heat-induced apoptosis in keratinocytes
Yoko Yoshihisa1, Mati Ur Rehman1,2, Takashi Kondo2, Tadamichi Shimizu1
1
Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan,
2
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama,
Japan
P02-05
[C09-02]
Quercetin is a possible agent for combination therapy with vorinostat
Kazuyasu Fujii, Miho Hatanaka, Atsuko Ibusuki, Takuro Kanekura
- 56 -
P02-06
[O3-25]
!
The sphingosine-1-phosphate S1PR1 axis as a potential therapeutic target in angiosarcoma
Daigo Oka1,2, Risa Koresawa1, Hideyo Fujiwara1, Hirotake Nishimura1, Isao Irei1, Takashi Akiyama1, Shuji Hamazaki1,
Yoshito Sadahira1, Wataru Fujimoto2, Mikio Masuzawa3
1
The First Department of Pathology, Kawasaki Medical University, Okayama, Japan, 2Department of Dermatology, Kawasaki Medical
University, Okayama, Japan, 3Department of Pathology Chemical, Allied Health Sciences, Kitasato University, Kanagawa, Japan
P02-07
[C09-01]
Identification of CD44 transcripts that segregate with proliferation, redox and differentiation activities in human
epidermal keratinocytes
Kwesi Teye1, Sanae Numata1, Norito Ishii1, Rafal_P Krol1, Takahiro Hamada1, Hiroshi Koga1, Daisuke Tsuruta2, Hideyuki Saya3,
Marek Haftek4, Takashi Hashimoto1
1
Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology,
Kurume, Japan, 2Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, 3Division of Gene
Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan, 4University of Lyon 1, EA
4169 and CNRS, Lyon, France
P02-08
[O3-26]
Epidermal growth factor receptor inhibitor induces TNFα via activation of the PPARγ and NF-κB in sebocytes
Atsuko Ashida, Eisaku Ogawa, Ryuhei Uchiyama, Hisashi Uhara, Ryuhei Okuyama
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
P02-09
[O3-27]
Identification of novel receptor tyrosine kinases in basal cell carcinoma
Hiroshi Mitsui1, James G. Krueger2, John A. Carucci3, Tatsuyoshi Kawamura1, Shinji Shimada1
1
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Japan, 2Laboratory for Investigative Dermatology, the
Rockefeller University, USA, 3Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, USA
P02-10
[O3-28]
Oxidative damage and Nrf2 (Nuclear factor erythroid 2-related factor 2) protein expression in normal skin and
keloid tissues
Kyu Uang Whang1, Jong Suk Lee3, Sung Yul Lee3, Je Min An1, Kyung O Kim2, Sun Bum Kwon1, Hyun ju Kim2
1
Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea, 2Department of Dermatology,
Soonchunhyang University College of Medicine, Bucheon, Korea, 3Department of Dermatology, Soonchunhyang University College
of Medicine, Cheonan, Korea
P02-11
[O3-29]
Triptolide induces antitumor activity in human melanoma cells via inhibiting transactivation of heat shock factor 1
Yoshitaka Nakamura, Yuko Nakatani, Akiko Nakamura, Masahiko Muto
Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
P02-12
[O3-30]
FAK and Src expression in premalignant and malignant skin lesions
Chong Won Choi1, Yoon Hwan Kim2, Hyunjoo Lee3, Won-Serk Kim2
1
3
Department of Dermatology, Seoul National University, Seoul, Korea, 2Department of Dermatology, Kangbuk Samsung Hospital,
Department of Pathology, Kangbuk Samsung Hospital
!
!
Category 3 (P03): Cell Adhesion Matrix Vascular Biology
P03-01
[II-3]
Anti-CX3CL1 monoclonal antibody: a promising therapy for systemic sclerosis
Vu H. Luong1, Takenao Chino1, Atsushi Tokuriki1, Noritaka Oyama1, Minoru Hasegawa1, Yoshikazu Kuboi2, Takashi Obara2,
Nobuyuki Yasuda2, Kenzo Muramoto3, Toshio Imai3
1
P03-02
[C09-08]
The Department of Dermatology-Fukui University, 2Eisai Co., Ltd., 3KAN Research institute. Inc.
Inhibitory regulation of apelin on fibrosis in systemic sclerosis
Yoko Yokoyama, Sachiko Ogino, Akihiko Uchiyama, Kazuya Yamada, Akihito Uehara, Osamu Ishikawa, Sei-ichiro Motegi
P03-03
[C09-07]
Classical cadherins control polarized organization of junctions and cytoskeleton in stratified epithelia
Matthias Ruebsam1, Akiharu Kubo2, Aaron Mertz3, Barbara Boggetti1, Gladiola Goranci1, Eric Dufresne3, Valerie Horsley3,
Masayuki Amagai2, Carien M. Niessen1
1
Department of Dermatology, University of Cologne, Cologne, Germany, 2Department of Dermatology, Keio University School of
Medicine, Tokyo, Japan, 3Yale University, New Haven, CT, USA
P03-04
[C09-06]
!
DJM-1 cells deficient in BP180 Type XVII collagen exhibit rudiment hemidesmosomes and abnormal pattern of
laminin-332 matrix
Yoshiaki Hirako, Ryotaro Kamo, Minori Kaneda
Division of Biological Science, Graduate School of Science, Nagoya University, Aichi, Japan
P03-05
[C09-05]
Mechanistic Insight into the Norepinephrine-induced Fibrosis in Systemic Sclerosis
Akihito Uehara, Kazuya Yamada, Akihiko Uchiyama, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi,
Osamu Ishikawa, Sei-ichiro Motegi
- 57 -
P03-06
[O3-31]
Epitope reduction of anti-desmoglein 1 autoantibodies in pemphigus foliaceus patients sera during clinical stages.
Yumi Aoyama1, Koji Kamiya2, Osamu Yamasaki3, Ken Ishii4, Aki Kamata5, Jun Yamagami5, Yoshiki Tokura2, Keiji Iwatsuki3
1
Department of Dermatology, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan, 2Department of Dermatology,
Hamamatsu University School of Medicine, Hamamatsu, Japan, 3Department of Dermatology, Okayama University Graduate School
of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 4Department of Dermatology, Toho University Omori Medical
Center, Tokyo, Japan, 5Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
P03-07
[O3-32]
Extra- and intracellular activities of COMP control collagen homeostasis in skin and fibrotic diseases.
Thomas Krieg, Beate Eckes
Department of Dermatology, Medical Faculty, University of Cologne, Cologne, Germany
P03-08
[O3-33]
Regulation of IL-33 expression is associated with keratinocyte adhesion, but not with differentiation.
Mayumi Komine1,2, Jitlada Meephansan3, Hidetoshi Tsuda1, Tomoyuki Oshio1, Shin-ichi Tominaga2, Mamitaro Ohtsuki1
1
Department of Dermatology, Jichi Medical University, 2Department of Biochemistry, Jichi Medical University, 3Department of
Dermatology, Chulabhorn International College of Medicine, Thammasat University
P03-09
[O3-34]
The role of basement membrane components on psoriasis in mice
Aki Natsumi, Koji Sugawara, Yukari Mizukami, Hisayoshi Imanishi, Daisuke Tsuruta
Department of Dermatology, Osaka City University Grduate School of Medcine, Osaka, Japan
P03-10
[O3-35]
Sebaceous Gland is a Hyaluronan Synthesis Organ in the Skin
Noriko Akimoto, Takashi Sato
Department of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
P03-11
[O3-36]
Profile of upregulated molecules in keloids
Misachi Asai1, Kazuya Kashiyama2, Yutaka Kuwatsuka1, Tatsushi Kiyohara1, Yumi Okubo1, Atsushi Utani1
1
Department of Dermatology, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Plastic
and Reconstructive Surgery, Tomishiro Central Hospital
Category 4 (P04): Human Clinical Research and Therapeutics
P04-01
[III-1]
Regulatory B cells are functionally impaired in patients with psoriasis
Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Hidemi Nakagawa
P04-02
[I-5]
Expression ability of RNAIII encoding δ-toxin in S. aureus isolated from infant skin is associated with atopic
dermatitis development
Yuumi Nakamura1, Yuzaburo Inoue2, Yuki Katayama1,2, Gabriel Nunez3, Naoki Shimojo2, Hiroyuki Matsue1
1
Department of Dermatology, Chiba University, Chiba, Japan, 2Department of Pediatrics, Chiba University, Chiba, Japan, 3Pathology
and Comprehensive Cancer Center, University of Michigan, Michigan, USA
P04-03
[I-3]
TLN-58, newly discovered hCAP18 processing form found in the lesion vesicle of palmoplantar pustulosis
Masamoto Murakami, Kana Masuda, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Mikiko Tohyama, Koji Sayama
Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan
P04-04
[C12-05]
Preferential expression of CD134, HHV-6 cellular receptor, on CD4 T cells in drug-induced hypersensitivity
syndrome
Fumi Miyagawa, Yuki Nakamura, Hideo Asada
Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan
P04-05
[C12-04]
!
Presence of anti-β2GP1 HLA-DR complex autoantibodies in the non-APS patients with recurrent limb
ulcerations
Noriko Arase1,2, Kenji Tanimura2,3, Jin Hui2, Sumiko Matsuoka2, Toshifumi Yamaoka1, Megumi Nishioka1, Eiji Kiyohara1,
Mamori Tani1, Koichiro Ohmura4, Hiroyuki Murota1, Hisashi Arase2,5, Ichiro Katayama1
1
Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan, 2Department of Immunochemistry,
Research Institute for Microbial Diseases, Osaka University, 3Department of Obstetrics and Gynecology, Graduate School of
Medicine, Kobe University, 4Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University,
5
Immunochemistry, Immunology Frontier Research Center, Osaka University
P04-06
[C12-03]
Distinct lymphocyte subsets responsible for classical and systemic hydroa vacciniforme
Tomoko Miyake1, Yoji Hirai1, Takenobu Yamamoto1,2, Masahide Imada1, Shin Morizane1, Toshihisa Hamada1, Hiroshi Kimura3,
Keiji Iwatsuki1
1
2
P04-07
[O2-01]
Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences,
Departments of Dermatology, Kawasaki Medical College, 3Departments of Dermatology, Nagoya University School of Medicine
Diminishing sweating in patients with tuberous sclerosis and the relationship to mTOR signaling pathway
Fei Yang, Mari Wataya-Kaneda, Lingli Yang, Ichiro Katayama
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
- 58 -
P04-08
[C12-01]
Induction of S100 calcium-binding protein A2 expression in keratinocytes by telaprevir and trichloroethylene
Manabu Yoshioka, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Yu Sawada, Daisuke Nisio, Motonobu Nakamura
University of Occupational and Environmental Health, Japan
P04-09
[C12-02]
Bath-PUVA therapy improves impaired resting regulatory T cells and increases circulating activated regulatory T
cells in psoriasis.
Ryoji Kubo1, Shinnosuke Muramatsu1, Yoko Sagawa1, Chiyo Saito1, Saori Kasuya1, Akiko Nishioka1, Emi Nishida1,
Sayuri Yamazaki2, Akimichi Morita1
1
Japan, 2Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
P04-10
[C02-07]
High-incidence of Kaposi’s sarcoma in Miyako Island can be contributed by both high prevalence of HHV8 and
male specific susceptibility gene
Ryoko Awazawa1, Harutaka Katano2, Daisuke Utsumi1, Kentaro Hayashi1, Hiroshi Uezato1, Kenzo Takahashi1
1
Department of Dermatology, University of the Ryukyus, Okinawa, Japan, 2Department of Pathology, National Institute of Infectious
Disease, Tokyo, Japan
P04-11
[C02-06]
A polarizing light microscopy can be an easy and reliable diagnostic tool of congenital keratinizing disorders
including Netherton syndrome
Daisuke Utsumi1, Hiroshi Uezato1, Hiroo Amano2, Yasushi Suga3, Kenzo Takahashi1
1
Department of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan, 2Department of
Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, 3Department of Dermatology, Juntendo University
Urayasu Hospital, Urayasu, Japan
P04-12
[O2-02]
VZV skin-test reaction, but not antibody, is an important predictive factor for postherpetic neuralgia
Kyoko Imoto1, Aiko Okazaki1, Fumitake Onishi2, Yoshiyuki Miyazaki2, Masayuki Okeda2, Shuichiro Yano2, Yukiko Takao2,4,
Yasuyuki Gomi2, Toyokazu Ishikawa2, Yoshinobu Okuno2, Yasuko Mori3, Hiroyasu Iso4, Koichi Yamanishi2,5, Hideo Asada1
1
Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan, 2The Research Foundation for Microbial
Diseases of Osaka University, Kagawa, Japan, 3Division of Clinical Virology, Department of Microbiology and Infectious Diseases,
Kobe University Graduate School of Medicine, Kobe, Japan, 4Public Health, Department of Social and Environmental Medicine,
Osaka University, Graduate School of Medicine, Osaka, Japan, 5National Institute of Biomedical Innovation, Ibaraki, Japan
P04-13
[C02-04]
!
Clinicopathological insights into the phenotypic variation of autosomal recessive hypotrichosis wooly hair by
c.736T>A LIPH mutation
Misaki Ise1,2, Akiharu Kubo2, Takashi Sasaki3, Noriko Umegaki-Arao2, Masayuki Amagai2, Manabu Ohyama1,3
1
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan, 2Department of Dermatology, Keio University
School of Medicine, Tokyo, Japan, 3KOSE Endowed Program for Skin Care and Allergy Prevention, Keio University School of
Medicine, Tokyo, Japan
P04-14
[C02-05]
!
Preferential suppression of Th17 infiltrate in psoriasis plaque by topical calcipotriol corticosteroid combination:
T cell propagation study
Toshiharu Fujiyama1, Kazuki Tatsuno1, Hayato Yamaguchi1, Hideo Hashizume1,2, Taisuke Ito1, Yoshiki Tokura1
1
P04-15
[C02-03]
Hamamatsu University School of Medicine, 2Shimada city municipal hospital
The presence of anti-phosphatidylserine-prothrombin complex antibodies in patients and model rats with
rheumatoid vasculitis
Tamihiro Kawakami1, Sora Takeuchi1, Yoshinao Soma1, Akihiro Ishizu2
1
Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan, 2Faculty of Health Sciences, Hokkaido
University, Sapporo, Japan
P04-16
[C02-02]
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis
Masaru Honma, Shin Iinuma, Kyoko Kanno, Shigetsuna Komatsu, Masako Minami-Hori, Hajime Iizuka, Akemi Ishida-Yamamoto
Department of Dermatology, Asahikwa Medical University, Asahikawa, Japan
P04-17
[C02-01]
Molecular imaging based skin cancer diagnostic platform
Miko Yamada1, Dennis Miller2, Julia Parrish-Novak2, Lynda Spelman3, Tarl Prow1
1
Dermatology Research Centre, University of Queensland, School of Medicine, Translational Research Institute, 2Blaze Bioscience,
Inc Seattle, WA, USA, 3Veracity Clinical Research, Brisbane, Australia
P04-18
[O2-03]
Analyzing the content of metabolites in sweat derived from subjects with atopic dermatitis by use of nuclear
magnetic resonance
Emi Ono1, Hiroyuki Murota1, Yuki Mori2, Yoshichika Yoshioka2, Ichiro Katayama1
1
P04-19
[O2-04]
Department of Dermatology, Osaka University, Osaka, Japan, 2Institute for protein research Osaka University
Characterization of the centrosome cycle in normal human epidermis, Bowen’s disease and squamous cell
carcinoma
Saori Watanuki1, Toru Atsugi2, Takashige Hirano3, Keiji Tanese4, Keisuke Kouyama5, Masayuki Amagai4, Akiharu Kubo4
1
Department of Dermatology, National Center for Child Health and Development, Tokyo, Japan, 2KOSÉ Corporation, Tokyo, Japan,
Maruho Corporation, Kyoto, Japan, 4Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 5Center for
Clinical Research, Keio University School of Medicine, Tokyo, Japan
3
- 59 -
P04-20
[O2-05]
Serum interleukin-6 levels in response to biologic treatment in patients with psoriasis
Shinnosuke Muramatsu, Ryoji Kubo, Emi Nishida, Yoichi Shintani, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
P04-21
[O2-06]
Secukinumab, a Novel Anti-IL-17A Antibody, Exhibits Low Immunogenicity in Clinical Trials and Human in vitro
Assays
Frank Kolbinger1, Andrew Blauvelt2, April Armstrong3, Todd Fox4, Jiaqing Huang5, Eric Liang6, Annette Karle1,
Sebastian Spindeldreher1, Gerard Bruin1, Kristian Reich7
1
Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Oregon Medical Research Center, Portland, Oregon, USA,
Department of Dermatology, Colorado Health Outcomes Program, University of Colorado, School of Medicine, Aurora, Colorado,
USA, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharmaceuticals, East Hanover, New Jersey, USA, 6China Novartis Institutes
for BioMedical Research Co., Ltd, Shanghai, China, 7Dermatologikum Hamburg and Georg-August-University Göttingen, Hamburg,
Germany
3
P04-22
[O2-07]
The impact of antiviral therapy on renal function in herpes zoster patients: A multiple linear regression analysis
of 211 cases
Akira Kasuya1, Hayato Yamaguchi1, Masahiro Aoshima1, Kazuki Tatsuno1, Shigeki Ikeya1, Takahiro Suzuki1, Tetsuya Kawamura2,
Toshiharu Fujiyama1, Taisuke Ito1, Yoshiki Tokura1
1
P04-23
[O2-08]
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan, 2Hamamatsu Higashi Hospital
Increased CCL22 expression levels in psoriatic skin predict the good response to infliximab.
Ikko Kajihara, Syuhei Kusumoto, Saori Yamada, Katsunari Makino, Asako Ichihara, Takamitsu Makino, Satoshi Fukushima,
P04-24
[O2-09]
Relationship between incidence of secondary failure and antibody formation to infliximab in Japanese psoriasis
patients
Emi Nishida, Shinnosuke Muramatsu, Ryoji Kubo, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University of Medical Sciences, Nagoya, Japan
P04-25
[O2-10]
The comparison of the microRNAs profiles as the diagnostic tool between the cutaneous type adult T-cell
lymphoma and mycosis fungoides.
Sayaka Yamaguchi, Takuya Miyagi, Yu-ichi Yamamoto, Hiroshi Uezato, Kenzo Takahashi
Department of Dermatology, University of the Ryukyus, Japan
P04-26
[O2-11]
Ten cases of antihistamine-resistant Dermographic Urticaria treated with oral cyclosporine
Keiko Hanaoka, Makiko Hiragun, Akio Tanaka, Mikio Kawai, Michihiro Hide
Department of Dermatology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan
P04-27
[O2-12]
Factors that affect the duration of antibody treatment for cellulitis
Makoto Inaoki, Chihiro Nishijima
Department of Dermatology, National Hospital Organization Kanazawa Medical Center
P04-28
[O2-13]
New approach of Gold nanoparticles for treating skin disease
Tarl Prow1, Nhung Dang1, Kaitlin Nufer1, Liz Payne1, H.Peter Soyer1, Matthew Foote2
1
Dermatology Research Centre, University of Queensland, School of Medicine, Translational Research Institute, 2Department of
Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia
P04-29
[O3-38]
Effects of topical agents containing VD3 analogues on serum calcium level in rats
Maho Hirabe1, Atsushi Hosomi1, Takuya Tokuda1, Hiroaki Nakamura1, Toru Amano1, Tadao Okamoto2
1
P04-30
[O3-39]
Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan, 2Leo Pharma K.K., Tokyo, Japan
Evaluation of an anti-dandruff treatment schedule against chronic recurrent seborrheic dermatitis
Virginie Turlier1, Cecile Viode1, Ophelie Lejeune1, Amandine Rouquier1, Christiane Casas1, Daniel Redoules1, Valerie Mengeaud1,
Jean-Baptiste Grieu2, Anne-Marie Schmitt1
1
Skin Research Center Pierre Fabre Dermo-Cosmétique Toulouse, France, 2Asian Innovation Center Pierre Fabre Dermo-Cosmétique,
Tokyo, Japan
P04-31
[O3-40]
Analysis of hair minerals in children with atopic dermatitis
Jeoung Eun Kim, Jae Min Shin, Won Seon Koh, Joo Yeon Ko, Young Suck Ro
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea
P04-32
[O3-41]
!
Efficacy and safety of the interleukin-12 interleukin-23 antagonist ustekinumab in Korean patients with moderate
to severe psoriasis
Kyu Uang Whang1, Young Lip Park2, Kyung O Kim2, Je Min An1, Sun Bum Kwon1, Jong Suk Lee3, Ga Hee Jung3
1
Department of Dermatology, Soonchunhyaung University Hospital, Seoul, Korea, 2Department of Dermatology, Soonchunhyaung
University Hospital, Bucheon, Korea, 3Department of Dermatology, Soonchunhyaung University Hospital, Cheonan, Korea
- 60 -
P04-33
[O3-42]
Fingernail Onychomycosis Caused by Molds: Epidemiology, Clinical and Laboratory characteristics
Charussri Leeyaphan, Sumanas Bunyaratavej, Sutasinee Phaitoonwattanakij, Chanai Muanprasat, Lalita Matthapan
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University
P04-34
[O3-43]
Usefulness of ultrasonography for rapidly diagnosing cutaneous sinus tracts of dental origin
Chinatsu Shobatake1, Fumi Miyagawa1, Takaya Fukumoto1, Toshiko Hirai2, Nobuhiko Kobayashi1, Hideo Asada1
1
Department of Dermatology, Nara Medical University, Nara, Japan, 2Department of Endoscopy and Ultrasound, Nara Medical
University, Nara, Japan
P04-35
[O3-44]
Histological analysis of the treatment for melasma and solar lentigo with low-fluence Q-Switched 1,064-nm Nd:
YAG Laser.
Chikako Kaminaka1,2, Fukumi Furukawa1, Yuki Yamamoto1,2
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Department of Cosmetic Dermatology and
Photomedicine, Wakayama Medical University, Wakayama, Japan
P04-36
[O3-45]
Clinical trial for evaluation of the efficacy and safety of monochromatic red and polychromatic white LED
devices for periocular wrinkles
Seung-Phil Hong, Chanhee Nam, Minyoung Jung, Misoo Choi, Minkee Park, Byungcheol Park, Myunghwa Kim
Department of Dermatology, Dankook University College of Medicine, Cheonan, Republic of Korea
Category 5 (P05): Epidermal Structure and Function
P05-01
[II-6]
Homeostatic cell turnover mechanisms that maintain tight junction barrier integrity in the epidermis
Mariko Yokouchi1,2, Mayumi Kajimura3, Makoto Suematsu3, Mikio Furuse4, Masayuki Amagai1, Akiharu Kubo1
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Nerima General Hospital, 3Department of
Biochemistry & Integrative Medical Biology, 4Division of Cerebral Structure, National Institute for Physiological Sciences
P05-02
[III-2]
Re-innervation of a skin model; functionality study
Valerie Andre-Frei1, Christine Jeanmaire1, Jean-Pierre Pennec3, Carine Tedeschi1, Schinichi Nakajima4, Laurent Misery2,
Nicolas Lebonvallet2
1
BASF Beauty Care Solutions, France, 2Laboratory of Neurosciences, Faculty of Medicine, Brest, France, 3Faculty of Medicine and
Health Science, University of Brest, 4BASF Beauty Creations, Tokyo
P05-03
[C12-08]
!
!
The Nrf2 Keap1 pathway contributes to the pathogenesis of atopic dermatitis by directly regulating the IL33 ST2
pathway in the epidermis
Yosuke Ishitsuka, Dennis Roop
Department of Dermatology Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado
Anschutz Medical Campus
P05-04
[O1-01]
Sphingomyelin synthase knockout mice exhibit an ichthyotic phenotype with epidermal lipid abnormalities
Akihito Nishi1, Takeshi Ichikawa2, Shota Sakai3, Tadashi Yamashita1, Yoshihiro Tokudome2, Toshiro Okazaki4, Debra Crumrine5,
Yoshikazu Uchida5, Peter M. Elias5, Yoshio Hirabayashi6, Sumiko Hamanaka2,6
1
Laboratory of Biochemistry, Azabu University School of Veterinary Medicine, 2Laboratory of Dermatological Physiology, Faculty of
Pharmaceutical Sciences, Josai University, 3Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life
Science, Hokkaido University, 4Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical
University, 5Department of Dermatology, School of Medicine, University of California, San Francisco, 6Laboratory for Molecular
Membrane Neuroscience, Brain Science Institute, RIKEN
P05-05
[C12-07]
Decreased filaggrin level leads to sweat duct obstruction, a possible underlying mechanism of reduced sweating
in atopic dermatitis
Pawinee Rerknimitr1,2,3, Hideaki Tanizaki1, Atsushi Otsuka1, Yoshiki Miyachi1, Kenji Kabashima1
1
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Division of Dermatology, Department of
Medicine, Faculty of Medicine, Allergy and Clinical Immunology Research Group, Chulalongkorn University, Bangkok, Thailand,
3
Dermatology Unit, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
P05-06
[C12-06]
Initiation of cornification is regulated by Ca2+ and pH in isolated mouse stratum granulosum cells
Takeshi Matsui1, Yuki Furuichi1,2, Ai Hirabayashi2,3, Masayuki Amagai1,2
1
Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 2Department of Dermatology,
Keio University School of Medicine, 3KOSÉ Endowed Program for Skin Care and Allergy Prevention, Keio University School of
Medicine
P05-07
[C01-07]
Discovery of a novel parathyroid hormone family member in skin that regulates keratinocyte differentiation
Emi Sato1, Jun Muto2, Ling-juan Zhang1, Christopher Adase1, James A. Sanford1, Teruaki Nakatsuji1, Richard L. Gallo1
1
P05-08
[C01-06]
Department of Dermatology, University of California, San Diego, 2Department of Dermatology, Aichi medical University
TRAF6-dependent activation of keratinocytes triggers early immunological events in Th17 immune response
Reiko Matsumoto, Teruki Dainichi, Kenji Sakurai, Takashi Nomura, Kenji Kabashima
- 61 -
P05-09
[C01-05]
A novel RIPK1 function in human epidermal inflammation and keratinization
Nao Saito, Masaru Honma, Takashi Shibuya, Satomi Igawa, Mari Kishibe, Akemi Ishida-Yamamoto
Asahikawa Medical University, Hokkaido, Japan
P05-10
[O1-02]
Alterations of Epidermal Functions in 3 beta-hydroxysteroid-delta 8, delta 7-isomerase deficient (ConradiHunermann) Mice
Mao-Qiang Man, Carolyn Cheung, Peter M. Elias
dermatology, VAMC and University of California San Francisco, CA, USA
P05-11
[C01-03]
Wy14643, a PPARα agonist, down-regulates expressions of TARC and RANTES and up-regulates those of filaggrin
in cultured human keratinocytes
Wei Zhang, Takashi Sakai, Yutaka Hatano, Sakuhei Fujiwara
Department of Dermatology, Faculty of Medicine, Oita University
P05-12
[C01-04]
Increase of Prolactin-like protein expression by SIRT1 knockdown or cellular aging
Kohei Horimoto1, Risa Kunimoto2, Risa Hashimoto2, Naohiro Ueda2, Yoshiyuki Horio2, Toshiharu Yamashita1
1
Department of Dermatology, Sapporo Medical University School of Medicine, 2Department of Pharmacology, Sapporo Medical
University School of Medicine
P05-13
[C01-02]
Corneodesmosome degradation is disturbed in stratum corneum of atopic dermatitis lesional skin in spite of
kallikrein 7 over-expression
Satomi Igawa, Mari Kishibe, Takashi Shibuya, Nao Saito, Shin Iinuma, Masaru Honma, Akemi Ishida-Yamamoto
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
P05-14
[C01-01]
Knockdown of either filaggrin or loricrin increases the productions of IL-1α, IL-8, IL-18 and GM-CSF in stratified
human keratinocytes
Takashi Sakai1, Ryo Nishiyori2, Yutaka Hatano1, Wei Zhang1, Sakuhei Fujiwara1
1
Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan, 2Medical student, Faculty of Medicine, Oita
University, Oita, Japan
P05-15
[O1-03]
Pituitary adenylate cyclase-activating polypeptide promotes eccrine sweat secretion
Shun Sasaki1, Jun Watanabe2, Hirokazu Ohtaki3, Seiji Shioda4, Hirohiko Sueki1
1
3
P05-16
[O1-04]
Department of Dermatology, Showa University School of Medicine, Tokyo, Japan, 2Center for Biotechnology, Showa University,
Department of Anatomy, Showa University School of Medicine, 4Hoshi University School of Pharmacy and Pharmaceutical Sciences
Physiological impacts of carbonylated proteins in the stratum corneum
Hitoshi Masaki1, Yumiko Yamawaki1, Yuki Sagawa1, Taeko Mizutani1, Yuri Okano1, Difei Chen2, Jinhua Li3
1
School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan, 2ROLMEX (Shanghai) Biotechnology
Research, 3Nature Beauté (Shanghai) Cosmetics
P05-17
[O1-05]
An immunohistochemical and ultrastructural study of familial type- and non-familial type- white sponge nevus
Toshio Demitsu1, Yoshinori Jinbu2, Aki Yamamoto2, Naoka Umemoto1, Kozo Yoneda3, Hidetoshi Tsuda4, Mamitaro Ohtsuki4,
Yoshiyuki Mori2, Mayumi Komine4
1
Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama City, Japan, 2Department of Dentistry, Oral
and Maxillofacial Surgery, Jichi Medical University School of Medicine, 3Department of Dermatology, Faculty of Medicine, Kagawa
University, 4Department of Dermatology, Jichi Medical University School of Medicine
P05-18
[O1-06]
N-glycosylation in desmoglein is required for desmosome assembly
Seon-Pil Jin1,2, Jang-Hee Oh2, Eun Young Seo2, Jin Ho Chung1,2
1
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea, 2Department of Dermatology, Seoul
National University College of Medicine, Seoul, Korea
P05-19
[O1-07]
Sandalwood oil downregulates skin inflammation through 11β-HSD1 activation in keratinocytes
Saori Itoi-Ochi, Sayaka Matsumura, Mika Terao, Hiroyuki Murota, Ichiro Katayama
P05-20
[O1-08]
Non-Staining Imaging of Keratinocyte Differentiation with Stimulated Raman Scattering Microscopy
Shinya Iwanaga1, Mariko Egawa1, Kyoya Tokunaga2, Junichi Hosoi1, Yasuyuki Ozeki2
1
Shiseido Research Center, Yokohama, Japan, 2Department of Electrical Engineering and Information Systems, The University of
Tokyo, Tokyo, Japan
P05-21
[O1-09]
Intense pulsed light increases hyaluronan and CD44 in the epidermal keratinocytes and improves age-related
epidermal structure defects
Sang Eun Lee1, Hye Rang On1, Hee Jung Lee2
1
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea, 2Department of Dermatology, CHA Bundang
Medical Center, CHA University, Seongnam, Korea
- 62 -
P05-22
[O1-10]
Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis
Makiko Kido-Nakahara1, Khudishta M Aktar1, Masutaka Furue1,2, Takeshi Nakahara2
1
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Division of Skin Surface
Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
P05-23
[O1-11]
Regulatory roles of Syk in epidermal keratinocyte differentiation
Nan-Lin Wu1,2, Duen-Yi Huang3, Wan-Wan Lin3
1
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan, 2Department of Medicine, Mackay Medical College, New
Taipei City, Taiwan, 3Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
P05-24
[O3-46]
Inhibitory factors of semaphorin 3A expression in human epidermal keratinocytes
Yayoi Kamata1, Yoshie Umehara1, Mitsutoshi Tominaga1, Osamu Negi2, Hideoki Ogawa1, Kenji Takamori1,2
1
2
P05-25
[O3-47]
Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan,
Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan
Analysis of micro-inflammation in human keratinocytes by quantitative measurement of mechanical property
changes
Hyeongwon Choi1,
Min Kyung Shin2, Hey Jin Ahn2, Youngsook Son3, Hun-Kuk Park4, Kyung Sook Kim5
1
Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yong In,
Korea, 2Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea, 3Kyung Hee Institute of Regenerative
Medicine, Seoul, Korea, 4Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, Korea, 5Program
of Medical Engineering College of Medicine, Kyung Hee University, Seoul, Korea
P05-26
[O3-48]
!
Host defense protein S100A7 psoriasin regulates pores in the epidermis: aquaporins and tight junctions
Fumihiro Hattori1,2, Shigaku Ikeda1,3, Ko Okumura3, Mitsutoshi Tominaga4, Kenji Takamori4, Hideoki Ogawa3,
Kikumoto Okamoto2,5, François Niyonsaba3
1
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Mikimoto
Pharmaceutical Co., Ltd., Mie, Japan, 3Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo,
Japan, 4Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan,
5
Juntendo Clinical Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
P05-27
[O3-49]
Sandalwood oil enhanced Epithelial-Mesenchymal Transition and promoted wound healing
Sayaka Matsumura, Saori Itoi-Ochi, Mika Terao, Hiroyuki Murota, Ichiro Katayama
P05-28
[O3-50]
The presence of Glyceraldehyde-derived AGEs in the skin
Mami Yokota1, Yuri Okano2, Hitoshi Masaki2, Masayoshi Takeuchi3, Yoshihiro Tokudome1
1
Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, 2School of Bioscience and
Biotechnology, Tokyo University of Technology, 3Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical
University
P05-29
[O3-51]
Phosphate buffered saline induces filaggrin expression in a human epidermal keratinocyte cell line (HaCaT cells)
Kozo Nakai1, Kozo Yoneda1, Toshitaka Nakagawa2, Tetsuya Moriue1, Yasuo Kubota1
1
Department of Dermatology, Kagawa University, Kagawa, Japan, 2Department of Life Science Research Center, Kagawa University,
Kagawa, Japan
P05-30
[O3-52]
A novel imaging technique for skin dermal viscoelasticity and its correlation with dermal density
Min Ah Kim, Sun Young Park, Hae Kwang Lee, John Hwan Lee
Skin Research Institute, Amorepacific R&D Center, Yongin, Korea
P05-31
[O3-53]
Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda
Teruhiko Makino, Megumi Mizawa, Yuri Seki, Masao Hayashi, Tadamichi Shimizu
Department of Dermatology, University of Toyama, Toyama, Japan
P05-32[SE]
[O1-12]
Comprehensive analysis of long non-coding RNAs in keratinization
Toshifumi Nomura
!
Category 6 (P06): Epidemiology Health Service Research
P06-01
[O3-37]
Anti-aging Effects of Camellia Japonica flower extract on a pollutant-induced stress
Seoungwoo Shin, Minkyung Kim, Eunsun Jung, Deokhoon Park
- 63 -
!
Category 7 (P07): Genetic Disease Gene Regulation and Gene Therapy
P07-01
[II-4]
Mutations of zinc finger E-box binding homeobox 2 (ZEB2) leading to develop connecting tissue disorder similar
to Ehlers-Danlos syndrome
Mika Teraishi1, Mikiro Takaishi1, Kimiko Nakajima1, Seiji Mizuno2, Yoko Hiraki3, Toshiyuki Fukada4, Shinji Shimoda5,
Yoshinobu Asada6, Nobuaki Wakamatsu2, Takahisa Furukawa7, Shigetoshi Sano1
1
Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan, 2Department of Clinical Genetics, Central
Hospital, Aichi Human Service Center, Kasugai, Japan, 3Hiroshima Municipal Center for Child Health and Development, Hiroshima,
Japan, 4Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, 5Department of Anatomy-1, Tsurumi
University School of Dental Medicine, Yokohama, Japan, 6Department of Pediatric Dentistry, Tsurumi University School of Dental
Medicine, Yokohama, Japan, 7Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University,
Suita, Japan
P07-02
[C05-06]
Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family
Takuya Takeichi1,2, Arti Nanda3, Masashi Akiyama2, Hejab Al-Ajmi3, John_A. McGrath1
St Johns Institute of Dermatology, Kings College London, Guys Hospital, London, UK, 2Department of Dermatology, Nagoya
University Graduate School of Medicine, Nagoya, Japan, 3Asad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait
1
P07-03
[C05-04]
Disruptive effect of mutated polycystin-1 on keratin 17 polymerisation in polycystic kidney disease with
steatocystoma multiplex
Kozo Yoneda1, Kozo Nakai1, Toshio Demitsu2, Yasuo Kubota1
1
Department of Dermatology, Faculty of Medicine, Kagawa University, 2Department of Dermatology, Jichi Medical University,
Saitama Medical Center
P07-04
[C05-05]
Mitotic recombination causes frequent somatic reversion of a dominant KRT1 mutation in ichthyosis hystrix
Curth-Macklin
Shotaro Suzuki1, Toshifumi Nomura1, Toshinari Miyauchi1, Hideki Nakamura1, Masashi Akiyama2, Hiroshi Shimizu1
1
Nagoya University Graduate School of Medicine, Nagoya, Japan
P07-05
[C05-03]
Autoimmune Vitiligo is Associated with a Transcriptional Regulator that Affects Expression of HLA-A＊02: 01 In
Vivo
Masahiro Hayashi1,2, Ying Jin1,3, Daniel Yorgov4, Stephanie A Santorico1,4, James Hagman5,6, Richard A Spritz1,3
1
Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, USA, 2Department of
Dermatology, Yamagata University School of Medicine, Yamagata, Japan, 3Department of Pediatrics, University of Colorado School
of Medicine, Aurora, USA, 4Department of Mathematical & Statistical Science, University of Colorado Denver, Denver, USA,
5
Department of Biomedical Research, National Jewish Health, Denver, USA, 6Department of Immunology and Microbiology,
University of Colorado School of Medicine, Aurora, USA
P07-06
[C05-02]
A single laminin subunit deficiency alters other laminin expression depending on the mutated genes
Ken Natsuga1, Wataru Nishie1, Satoru Shinkuma1, Hideki Nakamura1, Mika Watanabe1, Naotomo Kambe2, Atsushi Hatamochi3,
Utako Kimura4, Yasushi Suga4, Hiroshi Shimizu1
1
Chiba University Graduate School of Medicine, Chiba, Japan, 3Department of Dermatology, Dokkyo Medical University School of
Medicine, Mibu, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan
P07-07
[O2-14]
Abnormal locomotion in the XPA-deficient cell
Seiji Takeuchi1, Makoto Sato2, Chikako Nishigori1
1
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 2Department of Anatomy
and Neuroscience, Graduate School of Medicine, Osaka University
P07-08
[O2-15]
Identification of an Palindromic Motif in the Upstream Region of ABCA12 required for Promoter Activity in
Cultured Human Keratinocytes
Yoshitaka Shimizu1, Yasushi Ogawa1, Kazumitsu Sugiura1, Jun-ichi Takeda2, Kaori Sakai-Sawada3, Teruki Yanagi3, Atsushi Kon4,
Daisuke Sawamura5, Hiroshi Shimizu3, Masashi Akiyama1
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Division of Neurogenetics, Nagoya
University Graduate School of Medicine, Nagoya, Japan, 3Department of Dermatology, Hokkaido University Graduate School of
Medicine, Sapporo, Japan, 4Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan, 5Department of
Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
P07-09
[C05-01]
Hyperpigmentation over the metacarpophalangeal joints as an initial cutaneous finding of hyaline fibromatosis
syndrome with ANTXR2 mutations
Kazumitsu Sugiura1, Atsuko Ohno2, Michihiro Kono1, Hiroshi Kitoh3, Kazuya Itomi2, Masashi Akiyama1
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Neurology, Aichi
Children’s Health and Medical Center, 3Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine,
Nagoya, Japan
- 64 -
P07-10
[O2-16]
New insights into the pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation
Sei-ichiro Motegi1, Yoko Yokoyama1, Sachiko Ogino1, Kazuya Yamada1, Akihiko Uchiyama1, Buddhini Perera1, Yuko Takeuchi1,
Hiroshi Ohnishi2, Osamu Ishikawa1
1
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan, 2Department of Laboratory
Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan
P07-11
[O2-17]
Generalized verrucosis caused by a GATA2 deficiency
Mai Hattori1, Akira Shimizu1, Hiroo Amano1, Osamu Ishikawa1, Takeki Mitsui2, Kyoichi Kaira3, Daisuke Oikawa4,
Fuminori Tokunaga4, Hajime Nakano5, Daisuke Sawamura5
1
Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, 2Department of Hematology, Gunma
University Graduate School of Medicine, Gunma, Japan, 3Department of Oncology Clinical Development, Gunma University
Graduate School of Medicine, Gunma, Japan, 4Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation,
Gunma University, Gunma, Japan, 5Department of Dermatology, Hirosaki University Graduate School of Medicine, Aomori, Japan
P07-12
[O2-18]
Analysis of wound healing-related chemokines in the sera of epidermolysis bullosa patients.
Inkin Ujiie, Yasuyuki Fujita, Wakana Matsumura, Shotaro Suzuki, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe,
Hiroshi Shimizu
P07-13
[O2-19]
Genetic testing in cases of nevoid basal cell carcinoma syndrome using next-generation sequencing
Yoshihiro Matsudate1, Yoshiaki Kubo1, Issei Imoto2
1
2
P07-14
[O2-20]
Department of Dermatology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan,
Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Downregulation of long thymic stromal lymphopoietin (TSLP) variant using antisense oligonucleotide
Zacharias A.D. Pramono1, Glenda G.K. Oh1, Dave K.B. Wee2, Mark B.Y. Tang1
1
Research Division, National Skin Centre, Singapore, 2Institute of High Performance Computing (IHPC, A＊STAR), 1 Fusionopolis
Way, #16-16 Connexis North, Singapore
P07-15
[O2-21]
COL5A1 gene mutation in three cases of classic type Ehlers-Danlos syndrome
Tatsushi Kiyohara1, Yumi Okubo1, Michiya Yamaguchi2, Mariko Yozaki1, Fumi Usui1, Masahiko Muto2, Sakuhei Fujiwara3,
Atsushi Utani1
1
Department of Dermatology, Nagasaki University Graduate School of Biochemical Science, 2Department of Dermatology,
Yamaguchi University Graduate School of Medicine, 3Department of Dermatology, Oita University
P07-16
[O2-22]
Mutation analysis of the IL36RN gene in Japanese patients with palmoplantar pustulosis
Toshifumi Takahashi, Noriki Fujimoto, Miho Kabuto, Takeshi Kato, Norikazu Fujii, Takeshi Nakanishi, Toshihiro Tanaka
Department of dermatology, Shiga university of medical science, Shiga, Japan
P07-17
[O2-23]
A case of xeroderma pigmentosum complementation group C with dyschromatosis on the covered area of the
skin
Taro Masaki1, Eiji Nakano1, Chikako Nishigori1, Tamio Suzuki2
1
Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe,
Japan, 2Department of Dermatology, Yamagata University Faculty of Medicine, Japan
!
Category 8 (P08): Tissue Regeneration Stem Cell and Wound Healing
P08-01
[I-7]
Inducible basal keratinocyte-specific knockout of the LamA3 gene: a model for wound healing and fibrosis?
Monique Aumailley1, Sabrina Koenig1, Takako Sasaki2, Monika Pesch1
1
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany, 2Department of Matrix Medicine, Faculty of
Medicine, Oita University, Oita, Japan
P08-02
[C03-07]
Generation of transgene-free induced pluripotent stem cells from keratinocytes of recessive dystrophic
epidermolysis bullosa patient
Wakana Matsumura, Yasuyuki Fujita, Satoru Shinkuma, Inkin Ujiie, Chihiro Nakayama, Kazuma Matsumoto, Toshifumi Nomura,
Riichiro Abe, Hiroshi Shimizu
P08-03
[C03-06]
Population of pluripotent stem cells Muse cells are possibly self-maintained in human adipose-derived stem cells.
Takeshi Yamauchi1, Kenshi Yamasaki1, Kenichiro Tsuchiyama2, Saaya Koike1, Setsuya Aiba1
1
Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi, Japan, 2Department of dermatology, Tohoku
University hospital, Miyagi, Japan
P08-04
[O3-01]
Hyaluronan catabolism modulates macrophage polarization and wound repair
Jun Muto1, Daisuke Watanabe1, Richard L. Gallo2
1
Department of Dermatology, Aichi Medical University, Nagakute, Japan, 2Department of Dermatology, University of California, San
Diego, La Jolla
- 65 -
P08-05
[C03-05]
Hair-follicle associated pluripotent (HAP) stem cells differentiate to beating cardiac tissue sheets
Aiko Yamazaki1, Masateru Yashiro1, Sumiyuki Mii1, Ryoichi Aki1, Yuko Hamada1, Nobuko Arakawa1, Katsumasa Kawahara2,3,
Robert M. Hoffman4,5, Yasuyuki Amoh1
1
Department of Dermatology, Kitasato University School of Medicine, 2Department of Physiology, Kitasato University School of
Medicine, 3Department of Cellular & Molecular Physiology, Kitasato University Graduate school of Medical Sciences, 4AntiCancer,
Inc., Ostrow Street, San Diego, CA, 5Department of Surgery, University of California San Diego, CA
P08-06
[C03-04]
Two distinct spontaneous regenerative activities to repair ionizing radiation-induced dystrophy in anagen
follicles
Wen-Yen Huang1, Hsien-Yi Chiu1,2,3, Sung-Jan Lin1,2
1
University, 3Department of Dermatology, Hsin-Chu Branch, National Taiwan University Hospital, Hsin-Chu City, Taiwan
P08-07
[C03-03]
Endothelialized and innervated 3D skin glycated model
Sebastien Cadau1, Sabrina Leoty-Okombi1, Schinichi Nakajima2,
1
P08-08
[O3-02]
Valerie Andre-Frei1,2
2
BASF Beauty Care Solutions, France, BASF Beauty Creations, Tokyo, Japan
Long-term maintenance and proliferation of murine skin epithelial stem cells by Wnt-3a in vitro
Yukiteru Ouji, Fukumi Nakamura-Uchiyama, Masahide Yoshikawa
Department of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Japan
P08-09
[C03-02]
From Hair to Heart: Nestin-Expressing Hair Follicle Associated Pluripotent (HAP) Stem Cells Differentiate to
Beating Cardiac Muscle Cells
Masateru Yashiro1, Sumiyuki Mii1, Ryoichi Aki1, Yuko Hamada1, Nobuko Arakawa1, Katsumasa Kawahara2,3, Robert M. Hoffman4,5,
Yasuyuki Amoh1
1
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan, 2Department of Physiology, Kitasato
University School of Medicine, 3Department of Cellular & Molecular Physiology, Kitasato University Graduate school of Medical
Sciences, 4AntiCancer, Inc., Ostrow Street, San Diego, CA, 5Department of Surgery, University of California San Diego, CA
P08-10
[C03-01]
Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability
Daisuke Nanba1,2,5, Chihiro Hiraoka1,2,3, Fujio Toki2,5, Ken Shiraishi4, Koji Sayama4, Hiromasa Miura3, Shigeki Higashiyama1,2
1
Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan, 2Department of Biochemistry
and Molecular Genetics, Graduate School of Medicine, Ehime University, Ehime, Japan, 3Department of Bone and Joint Surgery,
Graduate School of Medicine, Ehime University, Ehime, Japan, 4Department of Dermatology, Graduate School of Medicine, Ehime
University, Ehime, Japan, 5Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University,
Tokyo, Japan
P08-11
[O3-03]
TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury
Yelin Wu
P08-12
[O3-04]
Whisker follicles transplanted to the spine of nude mice for spinal cord repair generate extensive ectopic hair
growth
Wenluo Cao1,2,3, Lingna Li1, Sumiyuki Mii4, Yasuyuki Amoh4, Fang Liu3,
Robert M. Hoffman1,2
1
AntiCancer Inc., San Diego, CA, 2Dept of Surgery, University of California, San Diego, CA, 3Dept of Anatomy, Second Military
Medical University, Shanghai, China, 4Dept of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan
P08-13
[O3-05]
High glucose suppresses DDX5 to delay wound healing in diabetic mice
Hongquan Li, Wang Wang, Yuping Lai
P08-14
[O3-06]
Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche
Takaaki Yamada1,2,3, Seiji Hasegawa1,3,4, Yu Inoue1, Yasushi Date1,4, Akiko Yagami3, Naoki Yamamoto5, Satoru Nakata1,
1
Research Laboratories, Nippon Menard Cosmetic Co., Ltd., 2Department of Applied Cell and Regenerative Medicine, Fujita Health
University School of Medicine, Aichi, Japan, 3Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan,
4
Nagoya University-Menard Collaborative Research Chair, Nagoya University Graduate School of Medicine, Aichi, Japan, 5Laboratory
of Molecular Biology, Fujita Health University Joint Research Laboratory, Aichi, Japan
P08-15
[O3-07]
Silk fibroin produced by transgenic silkworms overexpressing the Arg-Gly-Asp motif accelerates cutaneous
wound healing in mice
Atsunori Baba1, Kasumi Kitayama2, Tetsuo Asakura2, Hideki Sezutsu3, Akihide Tanimoto4, Takuro Kanekura1
1
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan,
Department of Biotechnology, Tokyo University of Agriculture and Technology, 3Transgenic Silkworm Research Unit, National
Institute of Agrobiological Sciences, 4Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of
Medical and Dental Sciences
2
P08-16
[O3-08]
Antiaging property of Andrographis paniculata extract
Ji-young You, Kyung-Baeg Roh, Deokhoon Park, Eunsun Jung
Biospectrum, Korea
- 66 -
P08-17
[O3-09]
Phlorizin increases epidermal thickness and p63 positive cells with increased expression of type IV Collagen and
inhibition of MiR135b
Young-Ji Hwang1, Hye-Ryung Choi1, Kazumi Toyama2, Jung-Won Shin1, Kyoung-Chan Park1
1
Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Republic of Korea, 2P&G Group,
Kobe, Japan
P08-18
[O3-10]
Mechanism of Aloe vera gel on wound healing in human epidermis
Mariko Moriyama1, Hirokazu Kubo1, Yuka Nakajima1, Arisa Goto1, Junji Akaki2, Ikuyo Yoshida2, Yukio Nakamura2,
Takao Hayakawa1, Hiroyuki Moriyama1
1
Pharmaceutical Research and Technology Institute, Kindai University, Osaka, Japan, 2Kobayashi Pharmaceutical Co., Ltd., Osaka,
Japan
P08-19
[O3-11]
Hierarchy of Cells and Roles of Stem Cells in the Dermis
Yuichi Hasebe1,2, Seiji Hasegawa1,2,3, Yuichirou Ogata1, Satoru Nakata1, Masashi Toyoda4, Kenji Matsumoto5, Akihiro Umezawa6,
NIPPON MENARD COSMETIC CO., LTD, 2Nagoya University-MENARD Collaborative Reserch Chair Nagoya University Graduate
School of Medicine, Aichi, Japan, 3Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan, 4Research
Team for Geriatric Medicine (vascular medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, 5Department of Allergy
and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, 6Department of Reproductive
Biology, National Research Institute for Child Health and Development, Tokyo, Japan, 7Department of Applied Cell and Regenerative
Medicine, Fujita Health University School of Medicine, Aichi, Japan
1
P08-20
[O3-12]
Role of topical or systemic corticosteroid application on hot water-induced mouse burn models of various grades
Naotaka Doi, Yumi Nakatani, Yutaka Inaba, Nobuo Kanazawa, Fukumi Furukawa
Dermatology, Wakayama Medical University, Wakayama, Japan
Category 9 (P09): Hair and Cutaneous Development
P09-01
[C08-04]
Functional tight junction barriers in sebaceous glands: defects in holocrine secretion in claudin-1 deficient mice
Toru Atsugi1,2, Mariko Yokouchi1,3, Ai Hirabayashi4,5, Manabu Ohyama6, Masayuki Amagai1,4,5, Akiharu Kubo1
1
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Fundamental Research Laboratories, KOSÉ
Corporation, Tokyo, Japan, 3Department of Dermatology, Nerima General Hospital, Tokyo, Japan, 4Laboratory for Skin Homeostasis,
RIKEN Center for Integrative Medicine Sciences, Kanagawa, Japan, 5KOSÉ Endowed Program for Skin Care and Allergy Prevention,
Keio University School of Medicine, Tokyo, Japan, 6Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
P09-02
[C08-03]
BNIP3 PLAYS CRUCIAL ROLES IN THE DIFFERENTIATION AND MAINTENANCE OF EPIDERMAL
KERATINOCYTES
Hirokazu Kubo, Mariko Moriyama, Yuka Nakajima, Arisa Goto, Takao Hayakawa, Hiroyuki Moriyama
Pharmaceutical Research and Technology Institute, Kinki University, Osaka, Japan
P09-03
[C08-02]
!
Plasmacytoid dendritic cells as a key player in the initiation phase of alopecia areata-induced C3H HeJ mouse
Taisuke Ito, Takahiro Suzuki, Jun-ichi Sakabe, Atsuko Funakoshi, Yoshiki Tokura
Hamamatsu University School of Medicine
P09-04
[O2-24]
Roles of two sphingomyelin synthase isoforms in murine hair
Takeshi Ichikawa1, Akihito Nishi2, Shota Sakai3, Asami Makino4, Yoshihiro Tokudome1, Tadashi Yamashita2, Toshiro Okazaki5,
Yoshikazu Uchida6, Tetsuya Tsuchida7, Yoshio Hirabayashi8, Sumiko Hamanaka1,7,8
1
Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, 2Laboratory of Biochemistry, Azabu
University School of Veterinary Medicine, 3Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life
Science, Hokkaido University, 4Lipid Biology Laboratory, Advanced Science Institute, RIKEN, 5Division of Hematology and
Immunology, Department of Internal Medicine, Kanazawa Medical University, 6Department of Dermatology, School of Medicine,
University of California, San Francisco, 7Department of Dermatology, Faculty of Medicine, Saitama Medical University, 8Laboratory
for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN
P09-05
[C08-01]
Inducing hair follicle organogenesis with defined environmental protein factors
Sabrina Mai-Yi Fan1, Chien-Mei Yen1,2, Su-Hua Pan3, Yu-Ju Chen4,
Sung-Jan Lin1,2
1
University, 3Institute of Genomics and Proteomics, National Taiwan University, 4Institute of Chemistry, Academia Sinica
P09-06
[O2-25]
Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma
Gaku Tsuji1,2, Takamichi Ito1, Takeshi Nakahara1,3, Chikage Mitoma1,2, Akiko Hachiya2, Masaki Takemura2, Makiko Nakahara2,
Masutaka Furue1,2, Hiroshi Uchi2
1
Research and Clinical Center for Yusho and Dioxin, Kyushu University, Fukuoka, Japan, 2Department of Dermatology, Kyushu
University, Fukuoka, Japan, 3Division of Skin Surface Sensing, Kyushu University, Fukuoka, Japan
- 67 -
P09-07
[O2-26]
FGF18 Signaling Determines Radioresistance of Telogen Hair Follicles by the Arrest of Hair Cycling
Fumiaki Nakayama1, Sachiko Umeda1, Takashi Yasuda2, Mitsuko Kawano1, Mayumi Fujita1, Atsuko Ishikawa1, Toru Imamura1,3,4,
Takashi Imai1
1
Sciences (NIRS), Chiba, Japan, 2Radiation Emergency Medicine Research Program, Research Center for Radiation Emergency
Medicine, National Institute of Radiological Sciences (NIRS), Chiba, Japan, 3Biotechnology Research Institute for Drug Discovery,
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 4School of Bioscience and Biotechnology,
Tokyo University of Technology, Hachioji, Japan
P09-08
[O2-27]
FGF18 Maintains Hair Follicle Stem Cells after Radiation Exposure
Mitsuko Kawano1, Sachiko Umeda1, Takashi Yasuda2, Toru Imamura1,3,4, Takashi Imai1, Fumiaki Nakayama1
1
Sciences (NIRS), 2Radiation Emergency Medicine Research Program, Research Center for Radiation Emergency Medicine, National
Institute of Radiological Sciences (NIRS), 3Biotechnology Research Institute for Drug Discovery, National Institute of Advanced
Industrial Science and Technology (AIST), 4School of Bioscience and Biotechnology, Tokyo University of Technology
Category 10 (P10): Immunology 1: Adaptive Immunity
P10-01
[I-1]
Co-blockade of TIGIT and PD-1 signals in tumor-infiltrating cytotoxic T lymphocytes is an effective antimelanoma therapy
Takashi Inozume1, Tomonori Yaguchi2, Junpei Furuta1, Kazutoshi Harada3, Yutaka Kawakami2, Shinji Shimada1
1
Department of Dermatology, University of Yamanashi, Yamanashi, Japan, 2Division of Cellular Signaling, Institute for Advanced
Medical Research, Keio University School of Medicine, 3Department of Dermatology, Tokyo Medical University
P10-02
[C07-08]
Contribution of basophil-derived amphiregulin in prurigo-like skin inflammation
Takashi Hashimoto1,2,3, Takahiro Satoh1, Hiroo Yokozeki2
1
Department of Dermatology, National Defense Medical College, Saitama, Japan, 2Department of Dermatology, Graduate School,
Tokyo Medical and Dental University, Tokyo, Japan, 3Department of Dermatology, Yokohama City Minato Red Cross hospital,
Yokohama, Japan
P10-03
[C07-07]
Immunological function of Langerhans cells in HIV in vitro and ex vivo infection
Takamitsu Matsuzawa1, Tatsuyoshi Kawamura1, Youichi Ogawa1, Hiroaki Mitsuya2, Shinji Shimada1
1
Dermatology, University of Yamanashi, Yamanashi, Japan, 2Department of Infectious Diseases and Department of Hematology,
Kumamoto University School of Medicine, Kumamoto, Japan
P10-04
[C07-06]
EpCAM Expressed by Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously-applied Protein
Antigen
Takeshi Ouchi1,2, Mark_C Udey1
1
Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, 2Department of Dermatology, Keio University
P10-05
[C07-05]
Skin resident CD8+ T cells display low cytotoxic potential in healthy skin and fail to fully mature in primary
melanoma lesions
Judith A. Seidel1,4, Sian H. Henson1, Natalie Riddell1, Milica Vukmanovic-Stejic1, Malcolm H. Rustin2, Frank Nestle3, Katie Lacy3,
Arne N. Akbar1
1
4
P10-06
[O1-45]
University College London, 2Royal Free Hospital, London, United Kingdom, 3Kings College London, London, United Kingdom,
Kyoto University, Japan
Filaggrin gene mutations are significantly associated with food allergy in Japanese primary school children
Michihiro Kono1, Masashi Akiyama1, Toshifumi Nomura2, W. H. Irwin McLean3, Hiroshi Shimizu2, Kazumitsu Sugiura1,
Akira Hata4, Yoshitaka Okamoto5, Yuzaburo Inoue6, Yoichi Suzuki4,7, Naoki Shimojo6
1
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Dermatology,
Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Centre for Dermatology and Genetic Medicine, College of Life
Sciences and College of Medicine, Dentistry & Nursing, University of Dundee, Dundee, UK, 4Department of Public Health, Graduate
School of Medicine, Chiba University, Chiba, Japan, 5Department of Otolaryngology, Head and Neck Surgery, Graduate School of
Medicine, Chiba University, Chiba, Japan, 6Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan,
7
Department of Education and Training, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
P10-07
[O1-46]
Distinctive downmodulation of plasmacytoid dendritic cell functions by vitamin D3 analogue
Takahiro Suzuki, Kazuki Tatsuno, Taisuke Ito, Yoshiki Tokura
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
P10-08
[O1-47]
TSLP and IL-4 interact to promote mutual receptor expression on CD4+ T cells in atopic dermatitis
Kazuki Tatsuno, Toshiharu Fujiyama, Hayato Yamaguchi, Yoshiki Tokura
Department of Dermatology, Hamamatsu University School of Medicine
P10-09
[O1-48]
Increased serum soluble DNAM-1 levels and decreased membrane DNAM-1 expression on NK cells and CD8
+ cells in cutaneous T-cell lymphoma
Naomi Takahashi, Makoto Sugaya, Hiraku Suga, Tomonori Oka, Tomomitsu Miyagaki, Shinichi Sato
Department of Dermatology, University of Tokyo, Tokyo, Japan
- 68 -
P10-10
[O1-49]
Tumor-associated macrophages and stromal factors play roles at different stages in developing mycosis fungoides
Taku Fujimura, Sadanori Furudate, Aya Kakizaki, Yumi Kambayashi, Setsuya Aiba
P10-11
[O1-50]
Heparinoid blocks the triggering of keratinocyte-mediated inflammation by inhibiting ERK pathway
Ryo Utsunomiya1, Hidenori Okazaki2, Xiuju Dai1, Masamoto Murakami1, Ken Shiraishi1, Mikiko Tohyama1, Koji Sayama1
1
The Department of Dermatology, University of Ehime, Ehime, Japan, 2The Department of Dermatology, Ehime Prefectural Central
Hospital, Ehime, Japan
P10-12
[O1-51]
Murine models of epicutaneous sensitization to protease allergen, which leads to airway eosinophilia upon
subsequent airway challenge
Sakio Shimura1, Toshiro Takai2, Hideo Iida1, Seiji Kamijo2, Hirono Ochi1,2, Natsuko Maruyama2, Izumi Nishioka1,2,
Punyada Suchiva1,2, Akira Matsuda3, Hirohisa Saito1,4, Susumu Nakae1,5, Hideoki Ogawa1,2, Ko Okumura1, Shigaku Ikeda1,2
1
Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Department of Ophthalmology, Juntendo
University Graduate School of Medicine, Tokyo, Japan, 4Department of Allergy and Immunology, National Research Institute for
Child Health and Development, 5The Institute of Medical Science, The University of Tokyo
P10-13[SE]
[O1-52]
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses
Tetsuya Honda1, Yu Sawada1,2, Yuichi Kobayashi3, Motonobu Nakamura2, Yoshiki Miyachi1, Kenji Kabashima1,4
1
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Dermatology, University
of Occupational and Environmental Health, Kitakyushu, Japan, 3Department of Biomolecular Engineering, Graduate School of
Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan, 4PRESTO, Japan Science and Technology Agency,
Tokyo, Japan
Category 11 (P11): Immunology 2: Innate Immunity and Microbiology
P11-01
[II-5]
IL-17 produced by group 3 innate lymphoid and γδT cells is pivotal for host defense to epicutaneous candidiasis
via neutrophil activation
Mari T. Iwasawa1, Yuumi Nakamura1, Seiichiro Wakabayashi1, Shinobu Saijo2, Hiroyuki Matsue1
1
The Department of Dermatology, Chiba University, Chiba, Japan, 2Medical Mycology Research Center, Chiba University, Chiba,
Japan
P11-02
[C08-08]
Decreased signaling of stem cell factor transforms bone marrow-derived cultured mast cells into M2
macrophage-like cells.
Seiichiro Wakabayashi, Yuumi Nakamura, Hiroyuki Matsue
Dermatology, Chiba University, Chiba, Japan
P11-03
[C08-07]
Cooperation of IL-1 and IL-36 plays a pivotal role in epicutaneous S.aureus-induced skin inflammation via IL-17
production
Seitaro Nakagawa1, Yumi Nakamura-Matsuoka1, Yuki Katayama1, Gabriel Nunez2, Hiroyuki Matsue1
1
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, 2Pathology and Comprehensive Cancer
Center, University of Michigan, Ann Arbor, MI, United States
P11-04
[C08-06]
SCF from keratinocyte delivers microbiome signals to skin mast cell
Anna Di Nardo, Zhenping Wang, Nicholas Mascarenhas
Dermatology Department, University of California San Diego
P11-05
[C08-05]
!
Dermokine β γ deficiency enhances imiquimod-induced psoriasis-like inflammation
Atsushi Tokuriki1, Takenao Chino1, Vu H. Luong1, Noritaka Oyama1, Kiyoshi Higashi2, Koichi Saito2, Minoru Hasegawa1
1
Department of Dermatology, University of Fukui, Fukui, Japan, 2Environmental Health Science Laboratory, Sumitomo Chemical Co.,
Ltd., Osaka, Japan
P11-06
[C11-02]
Effects of antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, on human
mast cell functions
François Niyonsaba1,2, Ko Okumura1, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Faculty of International Liberal
Arts, Juntendo University, Tokyo, Japan
P11-07
[C11-01]
Role of basophils and eosinophils in the development of pruritus
Chisa Nakashima, Atsushi Otsuka, Kenji Kabashima
P11-08
[O2-28]
An unfavorable shift from Treg to Th17 development can be preventable by selective depletion of IL-6producting proinflammatory monocytes
Ryo Takahashi1, Yukiko Ushigome2, Tetsuo Shiohara1,2
1
Division of Flowcytometry, Kyorin University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology, Kyorin
- 69 -
P11-09
[O2-29]
!
!
Angiogenic peptide (AG) -30 5C activates human keratinocytes to produce cytokines chemokines, migrate and
proliferate via MrgX receptors
Chanisa Kiatsurayanon1,2, François Niyonsaba1, Shigaku Ikeda1,2, Ko Okumura1, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology,
Juntendo University Graduate School of Medicine, Tokyo, Japan
P11-10
[O2-30]
IL-33 promotes ICAM-1 expression via NF-kB in murine mast cells
Takafumi Numata, Tomonobu Ito, Tatsuo Maeda, Chizu Egusa, Ryoji Tsuboi
Department of Dermatology, Tokyo Medical University
P11-11
[O2-31]
Stem Cell Factor inhibited MHC class II expression in IL-33-treated mast cells
Tomonobu Ito1, Chizu Egusa1, Tatsuo Maeda1, Takafumi Numata1, Nobuhiro Nakano2, Chiharu Nishiyama3, Ryoji Tsuboi1
1
3
P11-12
[O2-32]
Department of Dermatology, Tokyo Medical University, 2Atopy (Allergy) Research Center, Juntendo University School of Medicine,
Department of Biological Science and Technology, Tokyo University of Science
House Dust Mite Allergen Induces Atopic Dermatitis via Toll-like Receptor 1 and 6 Triggering of Keratinocytes
Yong Hyun Jang, Weon Ju Lee, Seok-Jong Lee, Do Won Kim
Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea
P11-13
[O2-33]
The novel antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) activates
Panjit Chieosilapatham1,2, François Niyonsaba1, Chanisa Kiatsurayanon1,2, Ko Okumura1, Shigaku Ikeda1,2, Hideoki Ogawa1
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology and
Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan
P11-14
[O2-34]
TGF-β-induced suppression of mast cell functions is mediated by the transcription factor Ehf
Nobuhiro Nakano1, Susumu Yamazaki2, Chiharu Nishiyama1,3, Ko Okumura1, Hideoki Ogawa1,4, Shigaku Ikeda1,4
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Pediatrics and
Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Department of Biological Science and
Technology, Tokyo University of Science, Tokyo, Japan, 4Department of Dermatology and Allergology, Juntendo University Graduate
P11-15
[O2-35]
Terminal differentiation of keratinocytes enhances TLR3 expression and anti-viral activity.
Yuriko Yamamura1, Shin Morizane2, Keiji Iwatsuki2
1
Center for Rheumatology, Okayama Saiseikai General Hospital, Okayama, Japan, 2Department of Dermatology, Okayama University
Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
P11-16
[O2-36]
Dissecting out the taxonomic heterogeneity within Propionibacterium acnes and proposal for two novel
subspecies of the species
Itaru Dekio1,2, Renata Culak2, Raju Misra3, Tom Gaulton2, Min Fang2, Masaru Tanaka1, Hans-Peter Klenk4, Dunstan Rajendram5,
Saheer E. Gharbia3, Haroun N. Shah2
1
Department of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan, 2Proteomics Research Unit,
Culture Collections, Public Health England, Colindale, London, United Kingdom, 3Genomic Research Unit, Public Health England,
Colindale, London, United Kingdom, 4School of Biology, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Genomic
Services Unit, Public Health England, Colindale, London, United Kingdom
P11-17
[O2-37]
Effects of antimicrobial peptides on expression of axon guidance molecules in normal human epidermal
keratinocytes
Yoshie Umehara1, Yayoi Kamata1, Mitsutoshi Tominaga1, François Niyonsaba2,3, Hideoki Ogawa1,2, Kenji Takamori1,4
1
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, 2Atopy
(Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo
University, Tokyo, Japan, 4Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan
P11-18
[O2-38]
Increased expression of toll like receptors 3, 7, 8, and 9 in peripheral blood mononuclear cells in patients with
psoriasis
Hee Joo Kim, Hong Kyu Kang, Sung Hee Kim, Dong Youn Shin, Dae Suk Kim, Min-Geol Lee
Department of Dermatology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea
P11-19
[O2-39]
Keratolytic and comedolytic effects of topically applied benzoyl peroxide in hairless mice and rhino mice.
Kazuaki Okamoto, Rie Tamura, Keisuke Tabara, Takamichi Kitano, Shoji Kanayama, Hiroko Kido, Tomo Sasaki, Takayasu Moroki,
Fumiaki Ikeda, Tatsumi Matsumoto, Ritsuko Ishii
Research Laboratories, Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan
Category 12 (P12): Photobiology
P12-01
[I-6]
Antiinflammatory role of Langerhans cells and apoptotic keratinocytes in UVB-induced cutaneous inflammation
Mayumi Hatakeyama, Atsushi Fukunaga, Ken Washio, Kumiko Taguchi, Chikako Nishigori
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan
- 70 -
P12-02
[C06-05]
Longer wavelength UVB irradiation induces HMGB1 in keratinocytes without causing apoptosis
Kan Torii, Akimichi Morita
Department of Geriatric and Environmental Dermatology, Nagoya City University, Aichi, Japan
P12-03
[C06-06]
Ultraviolet B (UVB) exposure expands thymus-derived Foxp3＋CD4＋ regulatory T cells with distinctive phenotype
in the skin
Sayuri Yamazaki1, Mizuyu Odanaka1, Akiko Nishioka2, Saori Kasuya2, Shoryu Takayama1, Masaki Imai1, Osamu Taguchi2,
Akimichi Morita2
1
Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 2Department of Geriatric
and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
P12-04
[C06-04]
AhR-dependent COX-2 upregulation is involved in the mechanisms underlying voriconazole-induced UVassociated skin cancer development
Shigeki Ikeya, Jun-ichi Sakabe, Yoshiki Tokura
P12-05
[O3-13]
Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat
cells
Eun Ju Kim1,2,3, Yeon Kyung Kim1,2,3, Sungsoo Kim1,2,3, Ji Eun Kim1,2,3,
Dong Hun Lee1,2,3, Jin Ho Chung1,2,3,4
1
Department of Dermatology, Seoul National University College of Medicine, 2Laboratory of Cutaneous Aging Research, Biomedical
Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, 3Institute of Human-Environment Interface Biology,
Seoul National University, Seoul, Republic of Korea, 4Institute on Aging, Seoul National University, Seoul, Republic of Korea
P12-06
[C06-03]
Usefulness of flow-cytometry based nucleotide excision repair assay for diagnosis of xeroderma pigmentosum
variant type
Eiji Nakano, Seiji Takeuchi, Taro Masaki, Ryusuke Ono, Chikako Nishigori
Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan
P12-07
[O3-14]
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in
human skin
Dong Hun Lee1,2,3, Eun Ju Kim1,2,3, Yeon Kyung Kim1,2,3, Sungsoo Kim1,2,3,
Jin Ho Chung1,2,3,4
1
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea, 2Laboratory of Cutaneous
Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, 3Institute of HumanEnvironment Interface Biology, Seoul National University, Seoul, Republic of Korea, 4Institute on Aging, Seoul National University,
P12-08
[O3-15]
UV irradiation-induced production of monoglycosylated biglycan through downregulation of xylosyltransferase 1
in human dermal fibroblasts
Jang-Hee Oh1,2,3, Cheng Long Jin1,2,3,4, Mira Han1,2,3, Min Kyeong Shin1,2,3, Cheng Yao1,2,3, Chi-Hyun Park1,2,3,
Mira Choi1,2,3, Yeon Kyung Kim1,2,3, Se-Rah Lee1,2,3, Xinghua Yuan1,2,3,4, Zhe Hu Jin4, Jin Ho Chung1,2,3
Hanon Lee1,2,3,
1
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea, 2Laboratory of Cutaneous Aging
Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, 3Institute of Human-Environment Interface
Biology, Medical Research Center, Seoul National University, Seoul, Korea, 4Department of Dermatology, Yanbian University
Hospital, Yanji, Jilin, China
P12-09
[C06-02]
Comparisons of the effects of single and multi-wavelength irradiation photodynamic therapy using 5aminolevulinic acid
Hideyuki Masuda1,2, Makoto Kimura1,2, Akimichi Morita1
1
Japan, 2USHIO INC.
P12-10
[C06-01]
Enhancement of UVB-induced apoptosis and elimination of DNA damages by pre-irradiation of IRA does not
depend on the repair of DNA damages
Shizuka Okazaki, Yoko Funasaka, Seiji Kawana, Hidehisa Saeki
Department of Dermatology, Nippon Medical School, Tokyo, Japan
P12-11
[O3-16]
The Distinct Effect of UVB and Near-infrared Radiation on Sebum Secretion in Differentiated Hamster Sebocytes
Shoko Ojima1, Noriko Akimoto1, Hiroko Sugimoto1, Shiho Tanaka1,2, Mana Hirayama1,3, Yuko Takenaka1,3, Yuichiro Tsunemi3,
1
Tokyo, Japan
P12-12
[O3-17]
A novel effects of a novel ascorbic acid derivative, 3-O-laurylglyceryl ascorbate, on improvement of skin barrier
Yushi Katsuyama1, Tatsuya Tsuboi1, Sayaka Nakamura1, Norihisa Taira1, Hitoshi Masaki2, Masato Yoshioka1
1
SEIWA KASEI CO., LTD. Osaka, Japan, 2Tokyo University of Technology
- 71 -
P12-13
[O3-18]
Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of
HSP70-inducers
Keiko Usui1, Tsuyoshi Ikeda2, Keiko Inoue3, Kenichi Hamada3, Tohru Mizushima1
1
Department of Drug Discovery and Development, Faculty of Pharmacy, Keio University, Tokyo, Japan, 2Faculty of Pharmaceutical
Sciences, Sojo University, Kumamoto, Japan, 3Saishunkan Phamaceutical Co., ltd.
P12-14
[O3-19]
Carbonylated proteins in the stratum corneum generate reactive oxygen species under short wavelength visible
light
Taeko Mizutani, Yumiko Yamawaki, Yuri Okano, Hitoshi Masaki
School of Bioscience and Biotechnology, Tokyo University of Technology
P12-15
[O3-20]
The Effect of Near-infrared Radiation on the Skin of Hamsters
Misaki Minemura1, Noriko Akimoto1, Hiroko Sugimoto1, Shiho Tanaka1,2, Mana Hirayama1,3, Yuko Takenaka1,3, Yuichiro Tsunemi3,
1
Tokyo, Japan
P12-16
[O3-21]
The effects of inaudible ultrasound on UV-irradiated human skin equivalent
Hyangtae Choi
Skin Research Team, R&D center, Amorepacific Co. LTD., Korea
P12-17
[O3-22]
The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people―the
relationship with the usage―
Makoto Mizuno1,2, Kayo Kunimoto1, Mikiko Seigan1, Eiji Naru2, Koichi Kameyama2, Fukumi Furukawa1, Yuki Yamamoto1,3
1
Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 2Fundamental Research Laboratories, KOSÉ
Corporation, 3Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University
P12-18
[O3-23]
Up-regulation of expression of Heme oxygenase-1 by Psidium guajava extract
Yuumi Horibe2, Yoshiki Okita1, Keiko Usui1, Keiko Inoue2, Kenichi Hamada2, Tohru Mizushima1
1
Department of Drug Discovery and Development, Faculty of Pharmacy, Keio University, Tokyo, Japan, 2Saishunkan Phamaceutical
Co., Itd
Category 13 (P13): Pigmentation and Melanoma
P13-01
[II-2]
Novel non-cell autonomous role of epidermal polarity protein Par3 in melanocyte homeostasis and
melanomagenesis
Melina Mescher1,2, Matthias Ruebsam1,3, Peter Jeong1, Marina Kranen1, Jennifer Landsberg4, Max Schlaak3, Cornelia Mauch3,
Carien M. Niessen1,2,3, Thomas Tueting4, Sandra Iden1,2
1
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany, 2Center for Molecular Medicine Cologne, University of
Cologne, Cologne, Germany, 3Department of Dermatology, University of Cologne, Cologne, Germany, 4Department of Dermatology
and Allergy, University of Bonn, Bonn, Germany
P13-02
[III-3]
Disruption of the autophagy-lysosome pathway is involved in hypopigmented macules in patients with tuberous
sclerosis complex
Lingli Yang, Fei Yang, Mari Wataya-Kaneda, Ichiro Katayama
Department of dermatology, Osaka University
P13-03
[C11-08]
TLR3 agonist Poly (I : C) enhance Rab27A and melanosome transportation through TLR3 and MAVS pathway in
human epidermal melanocytes
Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Mai Inoue, Kenichiro Tsuchiyama, Setsuya Aiba
P13-04
[C11-07]
IFN-β modulates chemokines from tumor-associated macrophages to enhance the therapeutic effect of anti-PD-1
antibodies in B16F10 melanoma
Aya Kakizaki1, Taku Fujimura1, Sadanori Furudate1, Yumi Kambayashi1, Takeshi Yamauchi1, Hideo Yagita2, Setsuya Aiba1
1
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Department of Immunology, Juntendo
P13-05
[C11-06]
Hair shaft miRNA-221 levels as a new tumor marker of melanoma
Satoshi Fukushima, Taisuke Inada, Masayuki Murai, Masatoshi Jinnin, Azusa Miyashita, Satoshi Nakahara, Aki Tokuzumi,
Hironobu Ihn
- 72 -
P13-06
[C11-05]
Aspirin induces cell death, TRAIL sensitization, and mitochondrial network abnormalities in human melanoma
cells
Itsuho Fujikawa1, Miki Suzuki-Karasaki1, Toyoko Ochiai1, Yoshihiro Suzuki-Karasaki2,3
1
Department of Dermatology, Nihon University Hospital, Tokyo, Japan, 2Innovative Therapy Research Group, Nihon University
Research Institute of Medical Science, Tokyo, Japan, 3Division of Physiology, Department of Biomedical Sciences, Nihon University
P13-07
[C11-03]
Cell division cycle associated gene 1 as a new therapeutic target for melanoma
Aki Tokuzumi, Satoshi Fukushima, Azusa Miyashita, Junji Yamashita, Satoshi Nakahara, Yosuke Kubo, Takamitsu Makino,
Department of Dermatology and Plastic Surgery, Faculty of Life Science, Kumamoto University, Kumamoto, Japan
P13-08
[C11-04]
Rhododendrol-induced cytotoxicity to melanocytes is enhanced by UVB exposure
Noriko Goto1, Taro Masaki1, Hiroshi Nagai1, Shosuke Ito2, Chikako Nishigori1
1
Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan, 2Department of Chemistry, Fujita Health
University School of Health Sciences, Toake, Aichi, Japan
P13-09
[O2-40]
Delta-like protein 3 promotes proliferation and migration of melanoma via MAPK activation.
Yukiko Kiniwa, Eisaku Ogawa, Aya Uchiyama, Naomi Kumagai, Ryuhei Okuyama
Department of Dermatology, Shinshu University School of Medicine, Nagano, Japan
P13-10
[O2-41]
Immunomodulatory effects of imiquimod cream on tumor-infiltrating leukocytes in B16F10 melanomas
Sadanori Furudate, Taku Fujimura, Aya Kakizaki, Yumi Kambayashi, Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
P13-11
[O2-42]
AT-rich interaction domain-containing protein 3B has a potential to be a new stem cell marker of melanoma
Satoshi Nakahara, Satoshi Fukushima, Junji Yamashita, Yosuke Kubo, Aki Tokuzumi, Azusa Miyashita, Masatoshi Jinnin,
Hironobu Ihn
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, University of Kumamoto, Kumamoto, Japan
P13-12
[O2-43]
Tumor-selective killing and TRAIL sensitization by garlic organosulfur compounds in human melanoma cells: role
of L-type calcium channel
Chinatsu Nakagawa1, Miki Suzuki-Karasaki1, Itsuho Fujikawa1, Toyoko Ochiai1, Yoshihiro Suzuki-Karasaki2,3
1
Department of Dermatology, Nihon University Hospital, Tokyo, Japan, 2Division of Physiology, Department of Biomedical Sciences,
Nihon University School of Medicine, Tokyo, Japan, 3Innovative Therapy Research Group, Nihon University Research Institute of
Medical Science, Tokyo, Japan
P13-13
[O2-44]
Immunohistopathological analysis of immature melanocytes from hair follicles of patients with Rhododenolinduced leukoderma
Ken Okamura1, Rintaro Ohe2, Yuko Abe1, Masao Ueki3, Yutaka Hozumi1, Gen Tamiya4, Kayoko Matsunaga5,
Mitsunori Yamakawa2, Tamio Suzuki1
1
Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan, 2Department of Pathological Diagnostics,
Yamagata University Faculty of Medicine, Yamagata, Japan, 3Biostatistics Center, Kurume University, Kurume, Japan, 4Tohoku
Medical Megabank Organization, Tohoku University, Sendai, Japan, 5Department of Dermatology, Fujita Health University School of
Medicine, Toyoake, Japan
P13-14
[O2-45]
Studies on the Melanosome-Phagocytic Activity of Human Dermal Fibroblast (HDF)
Haruka Kohda1, Mami Ishikawa1, Hirokazu Ishii2, Hideya Ando3, Masamitu Ichihashi4, Takahito Nishikata1
1
Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Japan, 2Marine Biological Laboratory,
Woods Hole, MA, USA, 3Department of Applied Chemistry and Biotechnology, Okayama University of Science, Okayama, Japan,
4
SAISEI MIRAI Clinic Kobe, Kobe, Japan
P13-15
[O2-46]
Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and
AP736 on viability of melanocytes
Chang Seok Lee, Yung Hyup Joo, Heung Soo Baek, Miyoung Park, Jeong Hwan Kim, Hong Ju Shin, Nok Hyun Park,
John Hwan Lee, Young Ho Park, Song Seok Shin, Hae Kwang Lee
Amorepacific R&D Center
P13-16
[O2-47]
Regulatory mechanisms of Emodin isolated from Polygoni Multiflori Ramulus on melanogenesis
Jongsung Lee, Sunghee Jang
Dept. of Genetic Engineering, Sungkyunkwan University, Suwon City, Gyunggi Do, Republic of Korea
P13-17
[O2-48]
Hermansky-Pudlak syndrome type 4: the second case in Japanese
Yuta Araki1, Yoshiyuki Ishii2, Yuko Abe1, Junko Yoshizawa1, Fumiki Okamoto3, Yutaka Hozumi1, Tamio Suzuki1
1
Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan, 2Department of Dermatology, Tsukuba
University School of Medicine, Ibaraki, Japan, 3Department of Ophthalmology, Tsukuba University School of Medicine, Ibaraki, Japan
- 73 -
P13-18
[O2-49]
IMP-3 expression predicts unfavorable prognosis in acral lentiginous melanoma
Yi-Shuan Sheen1,2, Yi-Hua Liao1, Hsien-Ching Chiu1, Shiou-Hwa Jee1, Yih-Leong Chang2, Chia-Yu Chu1
1
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan, 2Graduate Institute of Pathology, College of
Medicine, National Taiwan University and Department of Pathology, National Taiwan University Hospital
P13-19
[O2-50]
Inhibition of melanogenesis by Gaillardia aristata flower extract
Minkyung Kim
P13-20
[O2-51]
Diagnostic usefulness of dermoscopy in differentiating lichen aureus from nummular eczema
Min Soo Jang, Myeong Hyeon Yang,
Joon Hee Kim, Kang Hoon Lee, Sang Hwa Han, Kee Suck Suh
Department of Dermatology, Kosin University College of Medicine, Busan, Korea
P13-21
[O2-52]
Comparison of the Q-switched ND: YAG and Ruby lasers in treating semi-permanent make up
Kyu Uang Whang1, Young Lip Park2, Jong Suk Lee3, Ga Hee Jung3, Je Min An1, Kyung O Kim2, Sun Bum Kwon1
1
Department of Dermatology, Soonchunhyang University Hospital, Seoul, Republic of Korea, 2Department of Dermatology,
Soonchunhyang University Hospital, Bucheon, Korea, 3Department of Dermatology, Soonchunhyang University Hospital, Cheonan,
Korea
Late Abstract Submission
L-01
Immunological effects of granulocyte and monocyte adsorption apheresis (GMA) in the patients with
neutrophilic dermatoses
Masanao Sakanoue, Yuko Higashi, Takuro Kanekura
Kagoshima University, Department of Dermatology
L-02
Effective melanoma defense by turning tumor resident mast cells into T-cell recruiting immune sentinels
S. Kaesler1,2, F. Wölbing1, Y. Skabytska2, M. Köberle1, W. Kempf1, T. Volz1, M. Röcken2,
1
L-03
T. Biedermann1,2
2
Department of Dermatology and Allergy, TU Munich, Germany, Department of Dermatology, University of Tübingen, Germany
Identifying the biomarker of atopic dermatitis using TMT-labeling proteomic analysis
Jung U Shin1, Ji Yeon Noh1, Seo Hyeong Kim1,2, Ji Hye Kim1,2, Hyeran Kim1, Jin Shan1,2, Hemin Lee1, Jung Soo Lee1,
Chang Ook Park1, Ju Hee Lee1, Kwang Hoon Lee1,2
1
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine,
Seoul, Republic of Korea, 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
L-04
Detection of circulating IgE autoantibody to BP180 and its possible correlation with disease severity for urticarial
erythema
Eijiro Akasaka, Chihiro Kinjo, Noriko Takiyoshi, Takayuki Aizu, Yuki Kanda, Yuka Toyomaki, Hajime Nakano, Daisuke Sawamura
Department of Dermatology, Hirosaki University Graduate School of Medicine
L-05
Evaluation of oxidative stress in patients with psoriasis and atopic dermatitis by measuring the level of urinary 8OHdG
Junko Shimamoto, Nao Fukui, Hideaki Tanizaki, Teruo Kurokawa, Shinichi Moriwaki
Department of Dermatology, Osaka Medical College
L-06
Characterising severity cut offs and responsiveness of the Epidermolysis Bullosa Disease Activity and Scarring
Index (EBDASI)
Swaranjali V. Jain1,5, Adam G. Harris1,5, John C. Su2, David Orchard2, Lachlan J. Warren3, Hamish McManus4,
1
Dedee F. Murrell1,5
2
Department of Dermatology, St George Hospital, Sydney, Australia, Department of Dermatology, The Royal Children’s Hospital,
Melbourne, Australia, 3Department of Dermatology, Women’s and Children’s Hospital, Adelaide, Australia, 4Kirby Institute, University
of New South Wales, Sydney, Australia, 5Faculty of Medicine, University of New South Wales, Sydney, Australia
L-07
Striae distensae due to topical glucocorticoids is relatively rare in atopic dermatitis than psoriasis patients
Sung Jay Choe, Dong Hye Kim, Eun Jung Kim, Eung Ho Choi
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea
L-08
TNF-alpha and IL-17A increase SPINK5 expression in epidermal keratinocytes.
Satoru Sugihara, Shin Morizane, Saeko Sugimoto, Mina Kobashi, Keiji Iwatsuki
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
L-09
Increased efficacy of topical steroids using biodegradable microneedle patch in pruigo nodularis
Hong Kyu Kang, Jung U Shin, Jung Soo Lee, Howard Chu, Hemin Lee, Kwang Hoon Lee
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine,
- 74 -
L-10
Serum interleukin-6 and tumor necrosis factor-alpha levels may correlate with anti-tumor effect of nivolumab in
patients with metastatic melanoma.
Mikio Ohtsuka, Nobuyuki Kikuchi, Natsuko Matsumura, Takako Miura, Tomoko Hiraiwa, Toshiyuki Yamamoto
Department of Dermatology, Fukushima Medical University School of Medicine
L-11
Oral itraconazole for treatment of infantile hemangiomas and its possible molecular mechanisms investigation
Yuping Ran, Shuang Chen, Chan Mu, Xiaoxi Xu, Kaiyi Sun, Kaiwen Zhuang, Xiaowei Feng, Jiaoqin Tang, Qing Yang, Xin Ran,
Yao Lu, Daoxian Kang, Yalin Dai
Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China
L-12
BMP signalling and Sox2 in the Dermal Papilla regulates the Hair Follicle Stem Cell niche
Delia Quek, Jamien Lim,
Carlos Clavel
Hair & Pigmentation Development, A*Star Institute of Medical Biology, Singapore
L-13
Gene editing of COL7A1 genomic sequence to generate a new mouse model for RDEB using two steps counter
selection method based on HR
Joanna Jacków1,2, Lorenzo Anton-Louis Talà3, Matthias Titeux1,2, Alain Hovnanian1,2,4
1
Laboratory of genetic skin diseases, Inserm UMR1163 and Imagine Institute of Genetic Diseases, Paris, France, 2University Paris
Descartes-Sorbonne Paris Cite, Paris, France, 3Faculty of Life Science, École Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland, 4Department of Genetics, Necker Hospital, Paris, France
L-14
B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow
Kenichi Kato1, Takaaki Hanafusa1,4, Hiroaki Azukizawa1,5, Jun-ichi Miyazaki2, Junji Takeda3, Ichiro Katayama1
1
Department of Dermatology, Osaka University, Osaka, Japan, 2Division of Stem Cell Regulation Research, Osaka University, Osaka,
Japan, 3Center for Advanced Science and Innovation & Department of Social Environmental Medicine, Osaka University, Osaka,
Japan, 4Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan, 5Department of Dermatology, Nara
Medical University, Nara, Japan
L-15
Calcium but not 1,25 (OH)2 vitamin D3 or retinoic acid increases SPINK5 expression in epidermal keratinocytes
Mina Kobashi, Shin Morizane, Saeko Sugimoto, Satoru Sugihara, Keiji Iwatsuki
Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
L-16
New Hair Follicles Generated from Tissue Culture Expanded Adult Mouse Cells
Chih-Chieh (Tom) Chan1,2, Yi-Fen Mu1, Yi-Fan Chan1, Wei-Hung Wang2, Mai-Yi Fan2, Sung-Jan Lin1,2
1
Department of Dermatology, National Taiwan University Hospital and College of Medicine, 2Institute of Biomedical Engineering,
National Taiwan University Hospital
L-17
Epidermis-specific ablation of O-GlcNAc transferase (OGT) affects skin homeostasis
Ki-Duck Kim, Dae-Kyoung Choi, Sue Jeong Kim, Kyung-Cheol Sohn, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim,
Jeung-Hoon Lee
Department of Dermatology, Chungnam National University, Daejeon, Korea
L-18
!
!
!
TNF alpha, IL 17A, a Toll like receptor 3 ligand, and high calcium enhances the expression of SPINK6 in
epidermal keratinocytes.
Saeko Sugimoto, Shin Morizane, Satoru Sugihara, Mina Kobashi, Keiji Iwatsuki
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
L-19
Oncogenic mutations and epidemiology in cutaneous malignant melanoma
Tatsuya Kaji, Hiroko Katayama, Osamu Yamasaki, Masaki Otsuka, Minoru Takata, Keiji Iwatsuki
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama,
Japan
- 75 -

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