The largest life science cluster of the Netherlands

The largest life science
cluster of the Netherlands
2-BBB MEDICINES | 3D-ONE | 4WEB MEDICAL | ACHMEA | ACTIVEVIEW CONNECT GROEP | ADD2X
BIOSCIENCES | AEON ASTRON EUROPE | AIRBUS DEFENCE AND SPACE NETHERLANDS | ALRIJNE
ZIEKENHUIS | AMARNA THERAPEUTICS | AN VALUATIONS | APOTEX NEDERLAND | APPLIED RADAR
TECHNOLOGY | ASTP | ASTELLAS PHARMA EUROPE | AVERY DENNISON | BABYBLOOM HEALTHCARE
| BALANS LABORATORIUM LEIDEN | BASECLEAR | BATAVIA BIOSCIENCES | BIOFOCUS | BIOMARIN
NEDERLAND | BIOMIMIQ | BIOPARTNER CENTER LEIDEN | BIOSPARQ | BIOTOP MEDICAL | BIRD
RECRUITMENT | BISLIFE FOUNDATION | BOERHAAVE NASCHOLING | BRUKER | BUCHEM | CAM
BIOCERAMICS | CATEXEL | CELL SIGNALING TECHNOLOGY EUROPE | CENTRE FOR HUMAN DRUG
RESEARCH | CHILTERN INTERNATIONAL | CHIRALVISION | CLINICAL REACH DRUG DEVELOPMENT |
CLINICAL SCIENCE SYSTEMS | COMPAAN DESIGN | CONDI FOOD | CORPUS EXPERIENCE | COSINE
| CRUCELL | CSC | CULGI | CURARATA | CURIUM | CWTS | DARWIN DIGITS | DCPRIME | DE STAL
| DELTA CRYSTALLON | DELTAPATENTS | DIANOVA | DRIEHOEK RESEARCH SUPPORT | DUPONT
INDUSTRIAL BIOSCIENCES | EBMT CLINICAL TRIALS & STUDY OFFICE | EXPLANT TECHNOLOGIES
| FACIO THERAPIES | FIBRIANT | FITLAND XL LEIDEN | FLEXMERS | FORUM PHARMACEUTICALS
| FYTAGORAS | GALAPAGOS | GENERADE | GGZ LEIDEN RIVIERDUINEN | GIMARIS | GIOTTO
MANAGEMENT CONSULTANTS | GLOBAL TECHNICS | GOOD BIOMARKER SCIENCES | GOUTIER
LABORATORIES | HAL ALLERGY | HALIX | HAMPSHIRE HOTEL FITLAND LEIDEN | HARBOUR FIELDS |
HELPLINE | HILTON GARDEN INN | HOGESCHOOL LEIDEN | HOOGHEEMRAADSCHAP VAN RIJNLAND |
HUURMIJ | IDRIS SOLUTIONS | IEMO | IN OVO | INNOSER LABORATORIES | ISA PHARMACEUTICALS
| JANSSEN BIOLOGICS | KARBOR SERVICES | KENNISCENTRUM LEIDEN | LABOLUTIONS | LAP&P |
LEIDEN ACADEMIC CENTRE FOR DRUG RESEARCH (LACDR) | LEIDEN BIO SCIENCE PARK FOUNDATION
Content
Page
Page
7
Intro
80
Biotech Training Facility
8
Discover the park
86
Careers
24
Community
92
Park news
36
Research & Development
102
Infrastructural developments
48
Recent drug development
108
Join us
52
Pipeline
118
Whom to contact
Drug development services
& business services
129
Colophon
72
5
Welcome to
Leiden Bio Science Park
The key to discovery
6
Our park features over 90 dedicated
medical life sciences companies
and institutions, the largest number
of bioscience startups in the
Netherlands, several multinationals
and internationally acclaimed research
institutes.
Please have a look at this overview of the
Leiden Bio Science Park ecosystem, where
everything is in place for your science and
business to flourish.
This lively community is the gateway to
life science in Europe for companies and
institutions from around the globe.
The team of Leiden Bio Science Park
foundation
Thinking about joining the Leiden R&D cluster?
We’d love to have you on board!
7
Discover
the
The key to
drug discovery
Leiden Bio Science Park is the leading life sciences and health cluster
in the Netherlands and ranks among the top five most successful
R&D hubs in Europe.
It is a mature science cluster which includes drug development
companies in all phases of the value chain and the top academic
R&D institutes of Leiden University and Leiden University Academic
Center (LUMC).
8
9
An unique ecosystem that combines:
10
•
The largest Dutch cluster of biotech and pharmaceutical companies
•
Top academic research with a focus on translational drug research
•
World-class drug development service providers
•
Active collaboration between public and private stakeholders
•
State-of-the-art research and training facilities, including the Biotech Training Facility
•
Biopharmaceutical education at all levels, from academic to vocational lab training
•
An enthusiastic, well-trained and internationally oriented workforce
•
Two world-class museums: Naturalis Biodiversity Center and CORPUS
16.900
people are employed
at Leiden Bio
Science Park
11
Employees working at organisations at the park (1-1-2014)
696 public administration
3294 education
205 museums
Number of students life science and health related
4526
4795
5193
771 health care
12
6978 LUMC
306 other companies
603 companies active in other scientific areas
4054 life science companies
2011/2012
2012/2013
2013/2014
13
11 research institutes
Leiden Bio
Science Park
counts
173
organisations
8 educational institutions
10 health care organisations
14
other organisations
130 companies
14
15
130 companies of which:
93 biomedical (red) biotech companies
18 scientific areas other than life sciences
20 drug development companies
6 other non-scientific areas
4 provide services to health care organisations
10medtech companies
4 green biotech
16
93 biomedical (red) biotech companies, of which:
2 health care insurers
2 veterinary biotech
1 industrial (white) biotech
22 providing business services dedicated
to drug development
41 companies that provide drug
development services
17
Origin
divisions
with HQ
elsewhere
start-ups
20
relocations
27
companies
started here
35
spin-offs
from
academia
18
Nationality of the companies
51
14
10
joint
ventures
1
1
1
2
2
1
146 1
2
15 Belgium
Canada
France
Germany
Great Britain
Japan
Netherlands
Switzerland
Taiwan
USA
19
20
12 left
16 new
8 left
4 left
12 new
18 new
7 left
19 new
16907
15972
15270
15032
173
164
162
147
Development of the cluster
2011 2012 2013 2014
2011 2012 2013 2014
2011 2012 2013 2014
Number of
organisations at
the park
Employees working at
organisations
New organisations and
organisations that left
the park
21
Leiden Bio Science Park is proud to host a vibrant cluster of
companies & institutions, we name some:
2-BBB | ASTELLAS | BOERHAAVE CME
CENTER OF BIOSCIENCE AND DIAGNOSTICS | CHDR
CORPUS EXPERIENCE ON THE HUMAN BODY | GALAPAGOS
HAL ALLERGY | HOGESCHOOL LEIDEN | ISA PHARMACEUTICALS
JANSSEN BIOLOGICS | LACDR | LEIDEN FUTURELAB
LEIDEN UNIVERSITY | LEIDEN UNIVERSITY ACADEMIC CENTER (LUMC)
LEIDSE INSTRUMENTMAKERS SCHOOL | LIS ACADEMY | LUMC
NATURALIS BIODIVERSITY CENTER | OCELLO | PROQR | ROC LEIDEN
THE BIOTECH TRAINING FACILITY | TNO | TOXYS
Companies
Renowned research institutes
Biopharmaceutical education
Professional training programs
Academic programs
Amazing life science museums
22
23
Community
Committed
collaboration
Companies and academia at Leiden Bio Science Park together
invent, describe, screen, test, develop, produce and apply today’s
and tomorrow´s medical treatments. It is the people that make the
cluster work, and this makes us even more committed to foster this
special community.
To facilitate interaction, lots of meetings and partnering events are
regularly organised. In addition there are multiple social events and
formal and informal gatherings.
24
25
Thriving network
At Leiden Bio Science Park
you can join lots of events
Stimulating competitions
for young entrepreneurs
Networking gatherings
to bring people together
Networks
with colleagues
26
Partnering events
with investor pitches
Meetings
for the R&D community
Come
and
meet
the
park
at:
The monthly Life
Sciences Cafés
The annual BBQ
The CEO breakfast
meetings
The HR, business developers,
communication and R&D networks
The regular R&D events, such
as the Leiden Pharma Science
Symposia or the Tech Talks
27
Get
moving
and
join
us at:
The Life Sciences
soccer tournament
The Leiden Bio Science Park
sports day
1. Shuttle buses in rush hours
(OV BSP)
2. Recertification of safety
at the park (KVO)
The tennis tournament
The golf course
The running group
28
Facilities are in order
3. Improved mobility: extra
bus line, start of the road
works at Plesmanlaan
4. Start of the extension of
De Stal and development
of a new park next to it
5. Park maintenance is
addressed by Leo Zandvliet
29
Ample support
For companies and institutions based at Leiden Bio Science Park or
wishing to enter the park, the following supportive facilities are available:
•
•
•
30
LURIS
Technology Transfer Office
InnovationQuarter
Regional investment agency
Expat Centre Leiden
The Expat Centre Leiden welcomes and advises international employees
•
•
CHEC
K
OUR
WEBS
ITE
Entrepreneurial society OV BSP
Shared purchasing contracts,
the shuttle bus, maintenance and park management
Cluster development
The Leiden Bio Science Park
foundation enhances the network and further develops the cluster
•
•
•
De Stal
Grand café for lunches, events
and meetings
Starter’s support
Support for starting and young life sciences entrepreneurs
Hotels
In the direct vicinity of the park: Golden Tulip hotel,
Hampshire Fitland XL hotel,
Hilton Garden Inn, Holiday Inn,
Ibis hotel, Tulip Inn,
Van der Valk hotel Haagsche Schouw
•
•
Housing
Flexible offices and labs at the
incubator BioPartner Center,
multitenant buildings or ample space
to build your own premises
Meeting rooms at the park: BioPartner Auditorium,
CORPUS Congress Centre, Hampshire Fitland XL Leiden,
Grand Café De Stal,
Hilton Garden Inn, Holiday Inn Event
& Convention Center (ECC),
Kenniscentrum Leiden,
Leiden University,
Naturalis Biodiversity Center
31
32
33
Get started
on our park!
Do you have a great science-based business idea that you want to grow into
a company? Leiden Bio Science Park has the right network, financing tools and
locations to support you in making it a success!
As single point of contact we will:
engage individually with you,
speedily connect you with all relevant contacts and,
pragmatically get things done together with you.
34
Start-up
environment
If you are a student busy with
entrepreneurship we can offer
you the student entrepreneurs
club Lugus, as a place to spar
with peers and make your first
steps.
When financing becomes a topic
the Leiden TTO Luris has two
tailor made starter loans to help
you out.
Are you ready for an office or a
lab? The incubator BioPartner is
the place for you.
If you simply want to stay
up-to-date join our LinkedIn
starters group.
For more information on getting
started: please contact Barbara
Brunnhuber.
35
& t
h
c en
r
a
e
m
s
p
Re velo
De
Drug
development
At Leiden Bio Science Park 93 companies and organisations, together
with Leiden University and the LUMC are active in the life sciences R&D.
Here they develop innovative drugs, vaccines, diagnostics and platform
technologies.
They work, for instance, on solutions for major health issues like
infections, HIV, arthritis, brain diseases, various types of cancers, and
orphan diseases like Cystic Fybrosis and Duchenne Muscular Dystrophy.
36
37
Leiden Red Carpet videos
on drug development in Leiden
The Leiden Red Carpet series of short
videos show the most relevant steps in drug
­development as it takes place at Leiden Bio
Science Park.
You will find the videos at our website,
where you will also find information on the
accompanying walk through the park and app.
The Leiden Red Carpet series is developed by
the entrepreneurial society of the science park,
the OV BSP.
38
Biomedical companies
at Leiden Bio Science Park
2-BBB MEDICINES | 4WEB MEDICAL | AEON ASTRON EUROPE
AMARNA THERAPEUTICS | APOTEX | APPLIED RADAR TECHNOLOGY
ASTELLAS PHARMA EUROPE | AVERY DENNISON
BABYBLOOM HEALTHCARE | BIOMARIN | BIOSPARQ
BRUKER | CAM BIOCERAMICS | CRUCELL | DCPRIME
DELTA CRYSTALLON | FACIO THERAPIES | FIBRIANT
FORUM PHARMACEUTICALS | GALAPAGOS | HAL ALLERGY
ISA PHARMACEUTICALS | JANSSEN BIOLOGICS
MENTOR MEDICAL SYSTEMS | MYMETICS | PHARMING | PROQR
THE MEDICINES COMPANY | TLC BIOPHARMACEUTICALS
WELCH ALLYN
20 Drug development companies
10 Medtech companies
39
Successful
breeding ground
40
Ready for the future
Leiden Bio Science Park has seen companies
start from academic spin-off phase and grow
to SME´s or to stock market listed companies,
whereas others have been taken over by large
pharmaceutical companies.
The more than 30 years history
of ­Leiden Bio Science Park has
fuelled the next wave of young and
fast growing companies like ProQR
Therapeutics, ISA Pharmaceuticals,
2-BBB, and DCPrime.
For example, the successful company
Prosensa that grew up on Leiden, was
acquired by BioMarin in 2015. And the
Janssen family of companies of Johnson &
Johnson, includes former start-up Crucell, and
Centocor and Mentor.
And, the park attracted numerous
innovative service providers such as
Pluriomics (stem cell technology), Mimetas
(organ-on-a-chip), OcellO (3D drug discovery
screening services), BaseClear (genomics) and
many others.
World class clinical trial facilities are
available at the Centre for Human Drug
Research (early clinical evaluation of novel
therapeutics).
Together, the companies and institutions at
Leiden Bio Science Park are well prepared
as the leading cluster for innovative therapy
development in Europe.
41
Drug development environment
Modern therapy development is a complex
multidisciplinary endeavour requiring extensive interplay between academia, doctors,
pharmacists, development companies, service
providers including screening platforms, diagnostic tools and model development. The park
stimulates this interaction.
Leiden: inspiring environment
• Famous 17th century medical researchers:
• Franciscus Sylvius (1614-1672), observed the sick and discussed
possible treatment,
42
440 years of innovation
Leiden University (that celebrates its 440th anniversary in 2015) is an international research
university that cherishes its independent approach towards research and teaching. An approach that dates from the 17th century and
continues to attract innovative ­researchers.
• Herman Boerhaave (1668-1738), the first medical training at the
patients sickbed,
• 16 Nobel Prize laureates worked and
studied in Leiden.
Life
science
research
profiles
at
Leiden
University
and LUMC
Bioscience
the science base of health
Brain function
and dysfunction over the lifespan
Health
prevention and the human life cycle
Translational drug discovery
and development
Vascular
and regenerative medicine
43
LUMC research profiles
Vascular and
Regenerative medicine
Immunity, Infection
and Tolerance
Ageing
Innovation in Health
Strategy and Quality of Care
Translational Neuroscience
Biomedical Imaging
Cancer Pathogenesis
and Therapy
44
Research institutes
• Centre for Medical • Leyden Academy
• Institute of Biology Leiden
Systems Biology (CMSB)
on Vitality and Ageing
• Center for Translational • Naturalis Biodiversity
• Leiden Institute
of Advanced Computer Science
Molecular Medicine
Center
(CTMM)
• Leiden Institute for Brain and Cognition (LIBC)
• Leiden Academic Centre for Drug Research (LACDR)
• Centre for Human
Drug Research (CHDR)
• Mathematical Institute
• Leiden Institute of • Leiden Centre of
Chemistry
Data Science
• Leiden Institute of Physics
45
Leiden Bio Science Park
features state-of-the-art life
science research facilities
46
•
Cell Observatory
•
Leiden Genome Technology Center
•
Leiden Metabolomics Facility
•
Molecular Imaging Laboratories Leiden
•
Natural Products Lab
•
Netherlands Centre for Electron
Nanoscopy (NeCEN)
•
Ultra-high field NMR facility
Please look at the OARI website for an
overview of the Open Access Research
Infrastructure at Leiden University, Faculty
of Science.
47
Recent drug
developments
48
2-BBB Medicines
BioMarin
2-BBB’s lead product 2B3-101 completed
a Phase I/IIa trial treating patients with
various forms of cancer. The product
2B3-201 (several CNS indications) is
finishing a Phase I clinical trial in healthy
volunteers and MS patients.
In June 2015, BioMarin submitted the
New Drug Application at the FDA for
drisapersen, the lead candidate for
the treatment of Duchenne Muscular
Dystrophy, developed by Prosensa. The
European Medicines Agency (EMA)
validated drisapersen’s Marketing
Authorization Application, which means
that the submission is complete and the
EMA’s standard review process will start.
49
Galapagos
ISA Pharmaceuticals
Pharming
ProQR Therapeutics
In June 2015, the DARWIN 1 and
DARWIN 2 studies of Galapagos both met
their primary endpoint at 12 weeks of
treatment with the selective JAK1 inhibitor
filgotinib. Patients in both studies showed
improvements in signs and symptoms of
active rheumatoid arthritis.
Two Phase II clinical trials of ISA
Pharmaceuticals´s lead compound
ISA101 are currently ongoing in cervical
cancer and anal intraepithelial neoplasia.
In addition, clinical trials with ISA´s first
SLPR-AMPLIVANTR conjugates (ISA201
program) have been initiated in February
2015.
In July 2014 after a long trajectory,
Pharming celebrated the FDA approval
of Ruconest R for the treatment of acute
attacks of angioedema in patients with
Hereditary Angioedema (HAE) in the US,
and initiated a Phase II clinical trial to
investigate Ruconest R for the prophylaxis
of HAE.
ProQR Therapeutics successfully raised
funds of $102 million (€79.3 million) at
NASDAQ, $3 million from Cystic Fibrosis
Foundation Therapeutics, and €42 million
from institutional investors. The company
is preparing a first clinical trial for its
lead candidate, QR-010, an RNA-based
therapy for Cystic Fibrosis.
Results of the Phase II study with
filgotinib) in Crohn’s disease will be
available in Q4 2015, and the cystic
fibrosis program entered the clinic.
50
51
e
n
i
l
ipe
P
R&D
pipeline
The pipelines of drug development companies and research
institutions at Leiden Bio Science Park show successful results in
the development of their products.
Here is an overview of the disease areas, the pipeline and the
number of products in development of the companies and research
institutions at the park.
52
53
Disease
areas 2014
As the table shows, a large amount of
research and development is done in
the disease areas Infections, the Central
nervous system and the Cardiovascular
and circulatory system.
Number of products under development
per disease area in 2014.
54
Dermatology
13
Respiratory system
23
Kidneys and urinary system
29
Digestive system
34
Musculo-skeletal disorders
37
Autoimmune and inflammation
64
Central nervous system
92
Infections
97
Cardiovascular and circulatory system
87
Cancer
49
Pain
33
Metabolic/endocrinology
29
Miscellaneous
24
Blood and lymphatic system
17
Eye, ear
12
55
56
15
24
27
29
17
12
Phase I
Phase II
Pending approval
21
12
28
33
3
1
0
2
7
3
Phase III
18
14
2014
21
42
34
2013
Preclinical
4
Through the years a healthy influx of
new targets is being researched.
Please note also the progress towards
more products in phase III.
2012
28
This table shows the focus of Leiden
Bio Science Park on early stage drug
development. In 2014 21 products were
in the preclinical phase, 17 were in
Phase I, 15 in Phase II and 7 were
in Phase III.
2011
2
Number of
products in
development
Market
57
Leiden Bio
Science Park
drug
development
pipeline
An overview of the pipeline of companies
and research institutions at Leiden Bio
Science Park in 2014, as compiled from
publicly available information.
Source: Biopharm Insight
58
59
Which
companies
research
which disease
areas?
Apotex and Astellas stand out, due to
their many products on the market, while
most other companies are in product
development phases.
Per disease area percentage of company
pipeline products in 2014.
60
Companies
Apotex (AP)
Janssen
Astellas (AS)
Biologics (JB)
BBB
LACDR (LA)
Therapeutics (BBB)
LUMC (LU)
Crucell (CR)
Mymetics (MY)
Delta Crystallon (DEL)
Pharming (PH)
DCPrime (DCP)
ProFibrix (PF)
Facio Therapies (FT)
ProQR
Galapagos (GA)
Therapeutics (PRQ)
Forum
Prosensa (BMN)
Pharmaceuticals (FP)
TLC (TLC)
HAL Allergy (HA)
Top Institute
ISA
Pharma (TIP)
Pharmaceuticals (ISA)
ZoBio (ZB)
48% AP
13% HA
9% GA
9% AS
6% DEL
6% JB
2% BBB
2% CR
2% PH
2% MY
2% LU
Autoimmune and
inflammation
86% AP
11% AS
1% TLC
1% BBB
Cardiovascular and
circulatory system
65% AP
18% AS
6% CR
6% JB
6% PF
63% AS
16% AP
10% TLC
4% DCP
2% ZB
2% ISA
2% BBB
Blood and lymphatic
system
77% AP
13% AS
7% FP
1% BBB
1% BMN
1% TLC
Central nervous system
Cancer
62% AP
15% AS
15% GA
8% TIP
Dermatology 61
Companies
Apotex (AP)
Janssen
Astellas (AS)
Biologics (JB)
BBB
LACDR (LA)
Therapeutics (BBB)
LUMC (LU)
Crucell (CR)
Mymetics (MY)
Delta Crystallon (DEL)
Pharming (PH)
DCPrime (DCP)
ProFibrix (PF)
Facio Therapies (FT)
ProQR
Galapagos (GA)
Therapeutics (PRQ)
Forum
Prosensa (BMN)
Pharmaceuticals (FP)
TLC (TLC)
HAL Allergy (HA)
Top Institute
ISA
Pharma (TIP)
Pharmaceuticals (ISA)
ZoBio (ZB)
62
76% AP
18% AS
3% CR
3% LU
Digestive system
55% AP
45% AS
Metabolic/endocrinology
51% AP
28% AS
16% CR
2% MY
1% BBB
1% TIP
1% GA
Infections
41% AP
24% AS
19% BMN
11% GA
3% FT
3% TLC
Musculo-skeletal disorders
48% AP
48% AS
3% ISA
Kidneys and urinary system
58% AP
25% AS
8% TLC
8% PRQ
Eye, ear
63
Companies
Apotex (AP)
Janssen
Astellas (AS)
Biologics (JB)
BBB
LACDR (LA)
Therapeutics (BBB)
LUMC (LU)
Crucell (CR)
Mymetics (MY)
Delta Crystallon (DEL)
Pharming (PH)
DCPrime (DCP)
ProFibrix (PF)
Facio Therapies (FT)
ProQR
Galapagos (GA)
Therapeutics (PRQ)
Forum
Prosensa (BMN)
Pharmaceuticals (FP)
TLC (TLC)
HAL Allergy (HA)
Top Institute
ISA
Pharma (TIP)
Pharmaceuticals (ISA)
ZoBio (ZB)
64
65% AP
17% GA
9% AS
4% PRQ
4% CR
Respiratory system 67% AP
30% AS
3% GA
1
00% LA
Pain
Miscellaneous
65
Development
of research
per disease
area
Per disease area an overview
of the number of products in
development in each pipeline
phase in 2014.
Phases
Discovery (DIS)
Preclinical (PRE)
Phase I (P1)
Phase II (P2)
Phase III (P3)
Pending approval (PA)
Market (MA)
2 DIS
1 PRE
9 P1
7 P2
2 P3
43 MA
Autoimmune and inflammation
68
1 P2
1 P3
3 PA
12 MA
5 DIS
2 PRE
10 P1
8 P2
3 P3
1 PA
19 MA
Blood and lymphatic system
3 DIS
5 PRE
3 P1
3 P2
2 P3
76 MA
Central nervous system
1 PRE
86 MA
Cancer
1 DIS
2 P2
10 MA
Dermatology
Cardiovascular and
circulatory system
1 DIS
1 PRE
2 P2
1 PA
29 MA
Digestive system
69
10 DIS
5 PRE
3 P1
5 P2
5 P3
1 PA
67 MA
Infections
3 PRE
1 P1
8 MA
Eye, ear
70
1 DIS
3 P1
5 P2
1 P3
18 MA
Kidneys and urinary system
2 DIS
1 PRE
2 P1
1 P3
17 MA
Respiratory system
2 DIS
6 PRE
7 P1
3 P3
18 MA
4 P1
1 P2
1 PA
23 MA
Metabolic/endocrinology
1 DIS
2 P1
4 P3
26 MA
Musculo-skeletal disorders
24 DIS
Pain
Miscellaneous
71
Drug
development
services and
business
services
72
Drug development
services
Leiden Bio Science Park boasts an extensive cluster of drug
development support with companies and institutions that offer
services throughout the (bio)pharmaceutical value chain: from
target definition to a registered and ready-to-market product.
73
Services
throughout
the (bio)
pharmaceutical
value chain
Please find the latest overview of
available service companies at
our website.
74
Companies
s
ion s
sat
n
ani isatio
g
r
g O rgan
n
i
r
O
s
ctu
ice
ch
es
ufa
erv
vic
ear
ser ture
al s t Man t Res livery nish
s
i
l
r
t
a
ics
l
ing
i
nic
e
c
c
l
c
lyti ell Cu linica ontra ontra rug d ll & F enom roteo creen
G
P
Ana
C
C
C
C
D
Fi
S
BaseClear
Batavia Biosciences
Biofocus
Biomimiq
Centre for Human
Drug Reseach
Chiltern International
ChiralVision
Clinical Reach
Drug Development
FlexMers
75
Companies
HALIX
InnoSer Laboratories
LUMC
MicroSafe Laboratories
Miltenyi Biotec
Mimetas
OcellO
OctoPlus
OmniComm Promasys
Pluriomics
ProBase Pharma
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Protein Labelling Innovation Technologies
PROXY Laboratories
QuickZyme Biosciences
ServiceXS
Thermo Fisher Scientific
Toxys
Verilabs Nederland
ZF-pharma
ZF-screens
ZoBio
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Business services
3 Human resources
management
4 Management
consulting
Information management
2 Medical
translations
3 Cluster
development
3 Equipment,
suppliers
Clinical science systems, CSC,
Darwin Digits, helpLine, LAP&P,
MedVision360, Omnicomm Promasys,
Szienz
Management consulting
Cluster development
BioPartner Center Leiden,
Leiden Bio Science Park foundation,
OV BSP
Equipment, suppliers
3 Legal affairs
8 Information
management
Human resources management
Balans Laboratorium,
Bird Bioflex,
Harbour fields
Labolutions, MediRent, XTAC Analytical
Driehoek Research Support,
LifeScienceGO!,
LSJ Medisch Projectbureau,
Xendo
Medical translations
MediLingua,
Wilkens CS Medical Translations
Legal affairs
BioTop Medical,DeltaPatents,
LURIS
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Biotech
Training
Facility
Biotech
Training Facility
Starting January 2016 the facility is going to be a state-of-the-art GMP
training facility for the production of (bio-)pharmaceuticals, where
employees are trained in working under GMP and biosafety conditions
in a realistic environment.
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The Biotech Training Facility
in a nutshell
•
Commissioning process is offered as a training course
Training under up-to-date GMP and biosafety (up to level 2) conditions
•
Equipment demonstration facility
•
Taught by professional trainers
•
•
We will offer a flexible program and tailor-made courses
With rooms for common unit operations, Gowning rooms, Cleanrooms
(Class A to D)
•
An open, transparent structure
•
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•
•
Learn by doing
Also for technical personnel/
maintenance suppliers
Professional
trainers
& flexible
programme
At the Biotech Training Facility
experienced trainers from the industry
will train your employees. All unit
operations used in the industry will be
available.
We offer all sorts of training programs: 1-day
GMP introductions, SOP writing to complete
courses on cleaning validation, upstream &
downstream processing, process validations,
aseptic filling of vials, etc.
The facility also offers tailor-made courses, e.g.
to train how to use new equipment, train-thetrainer, training for support personnel, and
much more.
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Technical systems
Demonstration facility
A complete, open floor is
dedicated to the technical
installations. These too are
open for instruction and
can be used for GMPspecific training for technical
personnel and maintenance
suppliers.
The BTF itself will be a
splendid location for suppliers
of equipment, training or
consultancy to hold their
seminars or to test their
new equipment in a neutral
environment.
More information
on the Biotech Training
Facility?
Please contact Rebekah Bikker
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Human Capital
Careers
The Leiden Bio Science Park foundation invests in various activities
revolving around human capital. For example, the ‘LBSP HRM network’
and its bi-annual meetings allow local human resource professionals to
connect and to exchange knowledge, experiences and ideas.
Plenty of job opportunities
Companies at Leiden Bio Science Park are fast growing and there is
near constant need for well-educated personnel. Please have a look at
the many challenging job openings in the database at our website.
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Life science education
Leiden Bio Science Park offers a wide range of life science education from
vocational level, to PhDs and postdocs. There is:
• Vocational laboratory training at ROC Leiden,
• The vocational Leiden Instrumentmakers School,
• Laboratory studies at university of applied sciences
CHEC
K OUR
WEBS
IT
FOR M E
O
RE
INFOR
MATIO
N
Hogeschool Leiden, and
• Various academic careers in medicine, biomedical and biopharmaceutical sciences at Leiden University and the LUMC.
Career events
and workshops
Team
challenge!
Throughout the year at the park,
numerous career events and
workshops are organised, to bring
students and companies in contact.
A new experimental concept from
Hogeschool Leiden was launched:
Team challenge!
• Bètabanenmarkt for science faculty student
• ‘Employability outside academia’
for postdocs
In Team challenge, students from different
disciplines team up to address real-life
challenges issued by LBSP companies
or other organisations, such as a market
analysis or product testing.
• Manifestation for MBO students
• ICP career events for international students
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Red Career
Together with the OV BSP, the Red Career
project was started. This project will deliver a
series of 3 minute videos that illustrate the
broad range of jobs or careers at Leiden Bio
Science Park.
In particular, jobs will be selected where finding
the right professional can be difficult. The first
Red career ‘episode’ was produced to cover
the work of biochemistry technicians and was
filmed at Apotex Nederland.
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For more information on education
and labor market, please contact:
Thomas Dijkmans.
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Park news
Members of the Leiden Bio Science Park community celebrated several
anniversaries, won prizes, had their new facilities opened, or attracted
investments:
1. Avery Dennison officially opened their new sustainable European HQ
at the Oegstgeest area of the park.
2. The first investment of the regional
development agency Innovation
Quarter went to Leiden based
BabyBloom Healthcare, that develops ergonomic incubators.
1
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3. October 2014: start of the
construction of the unique
international Biotech Training
Facility, opening January 2016.
4. Charles River Laboratories acquired
Galapagos’ Argenta and BioFocus
service operations.
5. Condi food won the Herman
Wijffels Innovation Award 2014.
6. Facio Therapies raised €2 million for
its FSHD drug development program. FSHD is a rare, hereditary form of
muscular dystrophy.
3
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7. Mimetas raised $5.2 million and
$1.6 million for organ-on-a-chip
technology.
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8. Prosensa was taken over by
BioMarin Pharmaceutical for
$680 million.
9. Funds for the enlargement of the
Leiden instrumentmakers School
(LiS) were raised, so the plans can
be realized.
10. Mymetics’ promising HIV vaccine
candidate obtained funding to begin
a study at the Texas Biomedical Research Institute.
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11. By crowd funding and donations Naturalis raised enough funds to buy a T. rex skeleton. The grand old lady of nearly 12 meters can be admired from mid 2016 in the Pesthuis building.
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12. TomTom co-founder navigated into
biotech with investment in OcellO for the further development of their
3D cell models.
13. In Ovo raised €200,000 from the
Leiden University and €500,000 euro
to further develop the technique that can determine the gender of chicken
eggs.
14. Pluriomics raised €4 million from
several investors, including the
regional investment fund Innovation
Quarter, to accelerate the further growth of the company.
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15. ProQR raised $97.5 million at
NASDAQ for development of a
treatment of Cystic Fibrosis.
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16. Janssen announced the start of
Phase I clinical trials of a preventive Ebola vaccine.
17. To-BBB Therapeutics passed
through a rough period: the
company was renamed BBB
Therapeutics and went bankrupt.
Founder Pieter Gaillard who left
the company prior to the
bankruptcy, in 2015 restarted the
company under the new name
2-BBB Medicines.
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Infrastructural developments
Infrastructural
developments
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From the end of 2016,
traffic directed at the
science park will be able
to use the overpass at the
Plesmanlaan and the new
access road Ehrenfestweg.
This major investment
will end to the daily
infrastructural bottleneck at
the Plesmanlaan.
For faster connections with
the Oegstgeest part of the
science park by bus, bike
and on foot the Niels Bohr
tunnel (connecting the
Niels Bohrweg with the
Willem Einthovenstraat) is
available since July 2015.
The construction of the
RijnlandRoute, that will
link the highways A4 and
A44, is expected to start in
the beginning of 2016.
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Coming up
September 2015
Galapagos will move into
the new Beagle Zernike
multi-tenant building. In
January 2016 Batavia
Biosciences will also move
into the building.
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REA
D
October 2015 Opening of the redesigned
and landscaped
Leeuwenhoek park
with trees and a pond for
everyone’s enjoyment.
THE
AT O L ATES
AND UR WET NEW
SUB BSIT S
E
S
NEWTO OURCRIBE ,
SLE
T TE
R!
January 2016
Opening of the Biotech
Training Facility, first
courses will start.
Q2 2016 De Stal will reopen in their
new facilities with a larger
kitchen, storage and a
large south facing terrace.
September 2016
At the Beta Campus,
the new Faculty of
Science building of Leiden
University, phase I will
open.
Q3 2018 Naturalis: opening of the
enlarged and reorganised
museum with T-rex and
extra space for collections
and researchers.
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Leiden Bio Science Park welcomes new innovative life sciences
companies dedicated to drug development, advanced therapies and
personalized medicine in combination with diagnostics.
Join Us
5 reasons
to establish your company at Leiden Bio Science Park
•
Availability of labs and office space
•
•
•
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Strong R&D collaboration between academia and industry
Largest Dutch life science and
health cluster
•
Accessible state-of-the-art
research facilities
Vibrant international community
with a highly educated life sciences
labour force and students
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Well-developed
cluster
State-of-the-art
research facilities
Well
connected
The presence of a
well-developed cluster
of drug developing
companies, drug related
service providers,
business services and
top research institutions
makes Leiden Bio
Science Park an attractive
location to start-ups
as well as established
businesses.
The park also offers
access to state-of-theart research facilities and
equipment, numerous real
estate options and lots of
interaction and meetings.
Leiden is conveniently
located at only 20
minutes from Amsterdam
Schiphol Airport and is
well connected to the
main train lines and
highways.
Lots of
real estate
options
Leiden Bio Science Park offers you a
lot of options to settle. You can rent or
buy existing property. Or build your own
premises. Whatever your need, our park
has a fitting solution for you.
In close cooperation with the regional
investment agency InnovationQuarter we
offer tailor-made fact-finding visits and
introductions to our network.
111
26 companies joined us
The cluster boasts a healthy influx of new companies, both established international
companies and start-ups. In 2014 and 2015 twenty-six companies and organisations
joined the cluster.
2-BBB Medicines
4WEB Medical
AN Valuations
Avery Dennison
BioFocus
Bruker
DeltaPatents
Facio Therapies
Fibriant
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Generade
Global technics
Goutier
Huurmij
InnoSer lboratories
Karbor Services
Leiden Centre for
Data Sciences
Leiden Spin Imaging
MyLife Technologies
Mucosa
Piculet Biosciences
QVM
Stellar Space Industries
SysBioSim
Topaz Revitel
Toxys
Welch Allyn
Some examples of the
organisations that recently
joined our cluster
and computational methods for scientific
data within, among others, the domains of
life, health and bioscience.
Avery Dennison
American medical technology company
offering pharmaceutical labelling solutions,
electro medical adhesive products and
radio frequency identification inlays for
patients.
Mucosa
Mucosa is a tissue-engineering company
that developed a unique propriety platform
technology for oral skin transplantations.
Facio Therapies
Dutch start-up dedicated at developing
a therapy against the muscular disease
FSHD.
Leiden Centre for Data Science
Focuses on the development of statistical
Toxys
LUMC spin-out Toxys offers genotoxicity
testing services and won the HollandBio
BioBusiness Masterclass Award 2015.
Welch Allyn
American medical technology company,
offering digital and connected diagnostic
solutions.
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Why settle
in Leiden?
Leiden is an attractive environment
in which to work and live. It is an
internationally oriented, young and
culturally rich city. Home to the oldest
university in the Netherlands. Which is why
Leiden has a long tradition of knowledge
& science. No less than 16 Nobel Prize
winners are linked to Leiden.
114
Pleasant city
Leiden has a beautiful and vibrant city
centre, seeped in history with many canals
and monuments. It boasts 12 world-class
museums with amazing exhibitions on
antiquity, the arts, nature, science and
anthropology.
115
A welcoming place
for Expats
To underline the importance of
international knowledge workers to the
Leiden region, the Expat Centre was set
up. They advise expats on matters of
immigration, formalities and the practical
aspects of living, international schools and
social life in Leiden.
holds the forth place globally on the UN’s
Human Development Ranking - only
Norway, Australia and Switzerland have
higher scores.
For more information on establishing
at the science park: please contact
Ellen Smit.
High standard of living
The Netherlands is proud to provide a high
standard of living, while maintaining an
affordable life for its residents. It currently
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Whom to
contact
Facilitating
the cluster
Entrepreneurial society
The companies and organisations at the park are represented by the
entrepreneurial society of Leiden Bio Science Park (OV BSP) that, for
instance, lobbies for infrastructural
improvements, organises park
management and maintenance, and
manages joint facilities on the park.
For more information, please look at
the OV BSP website.
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119
Cluster development
The development of the cluster
is managed by the Leiden Bio
Science Park foundation. We
enhance the internal cohesion of the
cluster, manage projects (such as
on labour market and start-ups), do
the marketing communication of the
park, and we attract new life science
related organisations to the cluster.
For contact details, please look at
page 124.
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Incubation
Valorisation
Housing for young and maturing
companies is available at the
4 incubator buildings of the
BioPartner Center Leiden. The
Accelerator building is designed
for maturing companies, and there is a BioPartner Starters office for
start-ups. Networking events for young entrepreneurs are organised
by Science Meets Business.
The valorisation of Leiden University
and LUMC research is managed by
Luris. Luris is dedicated to knowledge
partnering between academia and
industry, it stimulates academic
entrepreneurship, and offers legal support and assistance in finding the right research funding.
For more information, please look at the
Luris website.
For more information, please look at
the BioPartner website.
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123
People involved
These are the facilities and the people behind them that make Leiden Bio
Science Park work.
Cluster development
Saco de Visser is responsible for the further
development of the Leiden Bio Science Park cluster.
Contact Saco de Visser (Director Cluster Development)
at +31 71 524 75 55.
Start-up support
Barbara Brunnhuber is your contact person
for all matters concerning starting a life science company.
Call Barbara Brunnhuber, Project Manager Starters
at +31 71 524 75 58.
124
Connecting education and companies at the park
Thomas Dijkmans is the one you need on all matters concerning
education and labour market at the science park.
Call Thomas Dijkmans, Project Manager Education & Labour
at +31 71 524 75 51.
Biotech Training Facility
For professional training in GMP and Biosafety in the realistic
environment of the Biotech Training Facility (operational January
2016), please contact Rebekah Bikker, Business Development
Manager Biotech Training Facility at +31 639 86 51 92.
Joining us and park management
Your first point of contact when you consider settling at the park
is Ellen Smit. For all matters on the OV BSP services, please also
contact Ellen Smit, in her role as Business Park Manager. You
can reach Ellen at +31 71 524 75 54 or +31 625 18 05 97.
125
Maintenance of the park
Management
For any issues concerning the maintenance of the science park,
please contact Leo Zandvliet, the OV BSP Maintenance
Manager, at +31 638 14 88 80.
Thijs de Kleer is director of both the BioPartner Center Leiden
and the Leiden Bio Science Park foundation (LBSPf).
Call Thijs de Kleer at the LBSPf at +31 71 524 75 56.
Urban planning
Marketing communication
The two municipalities at whose territory the science park is
located, Leiden and Oegstgeest, are much involved in facilitating
the further growth of the Park. Please look at their websites for
more information on urban planning at the park.
For all matters concerning the marketing and communication of
the park, please contact Hermine Klein, (Marketing Manager)
at +31 71 524 75 53.
Expat: warm welcome
To assist international knowledge workers in settling in
the Leiden region, the Expat Centre Leiden was set up.
Please have a look at the Expat Centre website.
126
New media
For all matters concerning start-ups and new media,
please contact Bas Schenkeveld, New Media Manager,
at +31 71 524 75 55.
127
Colophon
Office management
For any questions on the Life Sciences café, the website and
office management for the Leiden Bio Science Park foundation
and the OV BSP, please contact Carla van der Laan,
(Office Manager) at +31 71 524 75 55.
Leiden Bio Science Park foundation
Rijnsburgerweg 10
2333 AA Leiden
The Netherlands
From January 2016 our new address is:
J.H. Oortweg 19
2333 CH Leiden
The Netherlands
Publisher:
Concept and design: Leiden Bio Science Just, Leiden
Park foundation
Photography i.a. by:
Copy:
Marc de Haan
Leiden Bio Science OctoPlus
Park foundation &
Hans Lebbe
Just, Leiden
Studio Hartzema
+31 71 524 7555
Printing house:
[email protected]
Veenman+, Rotterdam
www.leidenbiosciencepark.nl
128
This issue gives you an overview of the Leiden Bio Science
Park ecosystem. Showing what this leading Dutch life
science cluster has to offer: the 90+ companies, Leiden
University and the LUMC, their research, the available
facilities and the thriving network.
Copies:
Rob Overmeer
September 2015
1.000
129
LEIDEN FUTURELAB | LEIDEN CENTRE OF DATA SCIENCE | LEIDEN PROBE MICROSCOPY | LEIDEN
SPIN IMAGING | LEIDEN UNIVERSITY | LEIDEN UNIVERSITY MEDICAL CENTER (LUMC) | LEIDSE
INSTRUMENTMAKERS SCHOOL | LEIDSE PROEFTUIN ZORG & WELZIJN | LEXISNEXIS UNIVENTIO |
LEYDEN ACADEMY ON VITALITY AND AGEING | LIFE SCIENCE METHODS | LIFESCIENCEGO! | LINK |
LIVING LAB VOOR ZORGINNOVATIES | LIVIT ORTHOPHEDIE | LSJ MEDISCH PROJECTBUREAU | LURIS
| MEDILINGUA | MEDIRENT | MEDIS MEDICAL IMAGING SYSTEMS | MENTOR MEDICAL SYSTEMS |
MICROSAFE LABORATORIES | MILTENYI BIOTEC | MIMETAS | MUCOSA | MYMETICS | NALCO | NATURALIS
BIODIVERSITY CENTER | NETHERLANDS CENTRE FOR ELECTRON NANOSCOPY (NECEN) | NEWCATCH |
NIJSSEN KOELING | OCELLO | OCTOPLUS | OMNICOMM PROMASYS | OV BSP | PHARMING | PHILA
DEL ART | PICULET BIOSCIENCES | PLURIOMICS | PRISNA | PROBASE PHARMA | PROMEGA | PROQR
THERAPEUTICS | PROTEIN LABELLING INNOVATION TECHNOLOGIES | PROTEONIC | PROTHIX | PROXY
LABORATORIES | QUALITY RA | QUICKZYME BIOSCIENCES | QVM | RIJNLANDS REVALIDATIECENTRUM
| ROC LEIDEN | SANQUIN BLOOD BANK | SCAL MEDISCH DIAGNOSTISCH CENTRUM | SERVICEXS |
SERVIER | SINENSIS LIFE SCIENCES | SODEXO | (SPORT)FYSIOTHERAPIE ERIK VAN PUTTEN | STICHTING
CONTACTEN BEDRIJFSLEVEN | STICHTING INTERPLAST HOLLAND | STICHTING LEVEDNA! | STICHTING
OPSPORING ERFELIJKE TUMOREN | STICHTING VALK | SYSBIOSIM | SZIENZ | THE MEDICINES
COMPANY | THERMO FISHER SCIENTIFIC | TLC BIOPHARMACEUTICALS | TNO | TOKO | TI PHARMA
| TOPAZ REVITEL | TOPLAB HOGESCHOOL LEIDEN | TOXYS | TROMBOSEDIENST LEIDEN | VERILABS
NEDERLAND | VERLOSKUNDIG CENTRUM DE POORT | VISIMETRIX | VISIO | VITALNEXT | WELCH
ALLYN | WILKENS CS MEDICAL TRANSLATIONS | WILLEM-ALEXANDER KINDERFONDS | XENDO | XTAC
ANALYTICAL | ZF-PHARMA | ZF-SCREENS | ZOBIO | ZORG ACADEMIE LEIDEN | ZORG EN ZEKERHEID
The premier life science hotspot
in the Netherlands
Leiden Bio Science Park is the leading life sciences cluster in the Netherlands
and ranks among the top five most successful science parks in Europe. It is
fully dedicated to biomedical life sciences and offers opportunities for both
established companies and start-ups to flourish.
www.leidenbiosciencepark.nl