PEqEH314f,
Transcription
PEqEH314f,
PEqEH314f, flxcepraqroHeH rpyA Ha TeMa ,, Bt3MO!|(HOCTX Ha ooro-aKTtlBl{paHata Ae3xHoeKqxn }r x:rrbqBaHero Ha ND: YAG ,ra3ep 3a enr4MrHxpaHeTo Ha Ha eHAOAOHTCKaTa i/t]tKpooropa " c agrop A-p qBererlHa reoprheBa feoprxeBa AoKtopcKa nporpa a: "Tepanesrn,iHa croMaronorni" , npooecuoHarHo Hanpa6reHre O3,O3.O1. OopMa Ha rqorropaHrypatai caMocrorrerHa noAroroBKa KbM XareApa no koHcepBaryBHo 3t6one'{eHre , OAM, MY-Coohr. HayqeH pbRoaoAner:npo0.A-p I.M. CnaB'.to KpyMos ArMurpos PeqeH3GtIE nfoo.q-p CrcrH EorHoE B.aAxMxpoq Alr Hayr,ta cneu,,a,,{occ TepaneBrx'rHa croMato^oryt UHciqut4f, : P\Ko@Atre Ha KareApa no OneparxBHo 3b6o^e{eHxe l,l aHAoAoHmg Oat<y ret no aeHra fla MqArqrHa, MeAxqtHcK, yHEBepcxrer-IlioEAliB BbHu.reH q/\eH Ha HeyqHoro xypr.r He3HaqeH cbc3anoaeA ilg PK3E-1021/28.05.201S, OflpeAeneH 3a peqerceHr cbrracHo nporoko, N91Ha HayqHoro AADoc x xyp, t(or.Exm: noulorc(s a,{tec:4OO0- IlioBAxB, 6y J(pxcfo Bor6B 3, Oal(y Iet no A€Hra Ha Meax|Irtla. Kareapa no oneparxBHo 3r6o/teqeHxe x eHApaorllxt EteKrponoH qapoc: stoyanvladimtrov@ abv.bli IM€oonri 032 602 666, 08aa$3704 PeqeKxrra B E ctorEarsllxa c xsrcxBaflkFta SPACPE lr npa6x^Hxxa Ha My- Ha Coori Gpx^oxeHxe 2) O6t4o npedcmoenxe na npoqedypama u doxmopaxma or Ao(Topafia AoKyMeHU Ga B cborB€tctBre c noco{eHrte ll3trcxBaHxt B npaBxnHrka Ha My-Cooxr, :hqrcreH e xaro AoKropaHr Ha caMocroFrerHa noatotoBl(a E XareApa no KoHGepBarxEHo 3rSorEqeHre, OAM-CoSrs c HayqeH npoo. A-p CraBqo ArmrrpoB (3anog€A N9PK36588/03.04.2014 r.). llpeAEraBeHl.le 1 KNnBU 6uozpo6uqBu AoH,,u A-p qBerer[Ha feoprneBa feoprneoa e poAeHa npe3 1980 r. npe3 1998 r. 3aBlpt[Ba rrMHa3h, , a npe3 2004 r. croMaTolorrf, BbB OAM, My {oonr. l4Ma pa3MnHaBaHe Mex(Ay 6uorpaorqHxre AaHHr, KbAero e nocoqeHo, qe ce eArnroMrpara xaro AeHTaIeH MeArx npe3 2OO2 r., a A|uoMara e r3AaAeHa npe3 2004 r. npe3 2005 r., cneA cneqereH xoHRypc e Ha3HaqeHa 3a aclicTeHr B KareApaTa no KoHcep8anaBHo 3r6oreqeHre BlB OAM{oour. npxAo6nla e cneqranHoo,, onepauaHo 3t6oreqeHre r eHAoAoHrrf, , npe3 2oo9 r. no HeiHr aaHHu BIaAee aHrnnickH u opeHo{x e3x(. llMa yqacrre B 3 x3c.reAoBare^cxx npoeKra Ha My-Coorf,. nposex(Aa npaxfl4,lec(I ynpaHHeHnf Ha cryAeHrx no AncqrnrnHaril ,l{oHcepBafliBHo 3!6ore9eHre,. Amyon Hocm Ho me Mamu Koma l,l36paHala reMa e amyarHa. Mxxpo6Hara ,Hoexqua e eAHa orocHoBHrre npuqrHl.l I 3a 3a6orrBaHrnTa Ha 3t6HaTa nylna x neproAoBqxyMa. ycnexbT Ha eBApAoHtcxoTo .reqeHre e clinHa 3aBrcnMocT, (aKTo or eoeKIxBHoTo n MaRcIMaIHO enrMl4HIpaBe Ha Mlit{poopraHy3MnTe oT r oT xepMerxqHoTo o6rypxpaHe Ha xopeHokaHarHoro npocrpaHcr8o c o eA HeaonycxaHe Ha pexHoekqxi. npl/l MexaHn'{HaTa o6pa6ofl{a Ha xaHara He e s!3MoxHo Aa ce nocTlrHe qr.rocTHo oTqrpaHt8aHe Ha MrxpoopraHl3Mhte nopaAr4 lHaa3rirTa rM B AeHTxHoBl4Te eHAOAOHTa, Taka ry6yr{, croxHara aHaroMl4, Ha eHAoAoHra x HeBt3MoxeH Ao6bn Ha HHcrpyMeHTme 8 (aHarr. ETo 3aqo rbpceHeTo Ha HoBl/l aHrr6aHTeprarH, cpeAqrBa l.l MeToat4 3a IaTepanHuTe Ae3rHoekqnn Ha eBAoAoHrir, xaKro n noAo6pnBaHeTo eonxacHocrra Ha l.3BecrHtTe e BaxHo, RaKro 3a HayqHaTa eHAoAoHTr,i, Taka l,l 3a MriHrqHara npa'N.fuxa. Toeo onpedeng 3Hoqu\ocmmo Ho p@po6omeHue om dot<mopoHmxomo npoekm. no?Haeaue Ha npodnena-numepamypen oStop OmeqaraHxrr AlcepraqnoHeH rpyA r,rna o6q o6eM 185 qraHAaprHx nplFrepHn crpaHxqx, or Koxro BlBeAeHxe- 1, 5 crp., nxreparypeH o63op c aHarx3 kbM Hero- 35 crp., qen u 3aAaqx- 1,5 crp., co6crBeH6 r3creABaHlr-82 clp., (Hxronxc- 30 srp. n npxroxeHla- fip. hMa cbpa3MepHocr MexAy orAerHxre ,iacrx Ha pa3pa6oreHrf, npoexr. ,nreparypHrrr o63op BR,loqBa 374 x3ToqHxRa, 15 or (ol,tro ca Ha xxpx.oxqa. 130 l,l3ToqHnKa ca or nocreAHlre LO toA$H\134,75%), Roero npaB[ Ao6po Bne,rarreHre t1 10 roBopx, (aKTo 3a aKryarHocna Ha npo6reMa, Ta(a x 3a xHoopMxpaHocra Ha AoKTopaHTa. HanpaseH e o6sroeH nper.neA Ha Hay\Hara ,xreparypa orHacaula ce 3a ttrluxpo$aopara npu at6r c npoBeAeHo eHAoAoHTcHo ne'reHre. Pa3rreAaHn ca Mlll(poopaaHtl3Ml,lre B KOpeHOBXTe (aHar, n B neplanlKanHxre TtkaHI, (aKIo x Ha BtapycHara xH0eKqxr. AHarx3l1paHx ca r3non3aaHrre B cbBpeMeHHHara eHAoAoHTx, MeroAx x cpeAcrBa 3a Bb3AeicrBle Bbpry MlxpoopfirHx3Mllle - RaHalHara xHcrpyMeHrallxn r nprraraHMle Macr'{eckrre r HoBra axnt6arrepraaxr paaraopr. Pa3TeAaH[ ca Bce non{eclo [3nor3BaHnre {oroglxamrru aErBHt4 cbeAnHeHxi ($oroceacr6raraaropr) u cBerrlHHxre ra3ro.rHtaqr r3nor3BaH[ 3a afirBaqrfl, xaKTo ,r MexaHr3MITe Ha aHlx6aKrepkarHoro AeiqrBlie ra $oto4txal\al,lxara repan{a !t Bb3MoxHoqrxre i 3a npxnoxeHxe B eHAoAoHTxaTa. ,( HanpaBeH eHAOAOHCHOTO e nperleA Ha ErcoKoeHeprxiHt{Te .[a3epHn cl4creMn nplraraHl,i npx re{eHl/le. numepqmypHuam o6?op e qenenocoqeB , docmqmt|fio uHQowqmuee| u dHqnumu.reH. JlpeAcraBerrre n xprrl{{Ho aHa.ru3rpaHr B ghBpeMe8Ha cBerrlHa nxreparypHlt AaHHI AaBaT Bb3MOXBOCT Ha AOrrOpaHE Aa HanpaBx o6o6qeHx ]t3BoAn, Rol,lTo BoArr Ao ,orlqHo onpeAelnHe Ha qenra ll 3aAa{l/lTe Ha Hacroruun AlcepraqnoHHx, TpyA. flocraBeHera {e, e OopmyllpaHa AcAo- c eKcDepuneHmonHu, no6opomoplu u KruHutlHu u3cnedeoHun dq ce otpHu ebexmuBHocmmo uo $omoceucu6unuaomopume u u3nbtleqHemo Ho Nd:YAG nBep 30 enu\uHupoHe Ho MuKpobnopamo npu endodonmcxo neqeHue. lDopMyr{paHx ca 6 ocHoBH14 3aAa'{x,Roxro ca Aocrarr'{Hl,r 3a nocIrraHe Ha qerra. Memoduxa xo uscnedeauemo (uamepudn u Memodu) B pa3Aela ,,Co6crBeHr npoyleatra" 4oxropaHt-a pa3rrexAa pa3AerHo r3nor3BaHm Marepxar, MeroAxRnre Ha n3cneABaHe, noIlI{eH[Te pe3y,lTarx, o66MaHero Ha pe3ynrarrre r 3aMK,qeHre no BcrKa or nocraBeHxre saAa,rx. pa3Aera 3aB.bpuJaa c 8 ocHoBHx r.r3BoAa. C,{nraM, ,{e o6eAxHrBaHero Ha Marep[ala c MeroAure Ha pe3yrrarxre c o6cbxAaHero qe orfipaHr t,t3lnuHxre noBTopeHxf, x 3arpyAHeHln BbB ab3npreMaHero Ha A[cepTal{xrra, Pa36xpa ce, r3nor3BaHara MaTp{qa npn npeAcraBaHeTo Ha TpyAa He HaMarraa HeroBara croiHocr. r ll3creAo8arerc$lFr Marepra, e Aocrarbgex no o6em aa 4a ce noryqar AocroaepHx pe3ylTaTx x ra3BoAn. h3no.n3BaHx ca 56 3b6a Ha naqreHT[ c AnarHo3a periodontitis chronica granulomatosa Hyx(Aaeqx ce or eHAoAoHTct{o re{eHne 3a r4eunr}xqlpaxe Ha M.o. or t{opeHoBl4Te XAHAIT. OnpeAeIeH e aHT[6arrepxarHxn eoeKr Ha OAA c 4 GeAlHeHxr- MerruteHoBo cl.tHbo, xeMaronopot.pnH, Zn- Ga (raalf,) {raaoqtaHxxu. I npx 40 e(qpaxxpaHr ropHo '{enlocrH}l pesqll c rrQexrnpaxr (opeHoBI xaxaau (aa Bcf,xa rpyna) in vitro e [3creABaH aHllr6aKTeprarHn, eoeKr Ha OM c Fotosan, Si- { Ga Sraaoqrarrxu, Nd:YAG na3ep , I Karo RoHrpola - alla6arrepuaarrn eoeKr Ha 3 npomrarr axu6arreplanHx pa3rBopa- Harplee xrnoxaopnr (2,5 %), xlopxe(cxA[H(2%) 14 rucropoAHa BoAa (3%). Bbpry 72 n,l.bxa nopoAa Wistar e ,r3creABaHa 6[onorxqHara noHoct{MocT Merarora,/loqxaHxHosr{ ooToceHcx6xnl43aTopx Ha 6a3ara Ha Zn- Ga npenapar Fotosan(karo xorrpoaa). HoBl,! OM 14 Ha Ha ABa TbproBcKyrr 3a npoyqBaHe c repMoBr,t3xoHHa KaMepa Ha reuneprypHxre npoMeHx a ar6rre npt ca x3noI3BaHn 72 eRcrpaxlpaHx ropHogerpcrHn pBq[(ra6opaTopHo x:cae4eaxe) I 8 naqxeHra npmeqeHxero Ha xpoHr'{eH nep[oAoHTrr Ha pe3qx x npemolapu( xaxHxqHo x3creABaHe). B xnxHx,lHoro npoy,{BaHe Ha OM c Fotosan l,| Nd:YAG ra3ep ca BfirIo,{eH}r 54 3-b6a Ha xonro e npoBex{AaHo eHAoAoHcxo IeqeHIe, pa3npeAeleH[ paBHoMepHo B rpx rpynxl)Bb3AeicrBr4e c Nd:YAG ,a3ep; 2) OM c Fotosan x aKrxBxpaHe c aaaep ,/laxcra Mtaod, u 3)- npoMxBrlr c HarpxeB xxnoMopxr x EATA ( xorrpoaa) MeroArire Ha x3creABaHe flpxnoxeHx ca ra6oparopH[, eRcneprMeBtarrn, urrpo6roaougHt4, xracrororlqHr , HnrHx.tHll I crarlfihqecxn MeroA[. MeroAxRxre ca npaBrnHo no46parr cuo6paaxo nocraBeHlTe 3aAa'{x. h3cneABaH[lTa ca npoaeaeH{ xopeKrHo caMocToflTelHo I a qbaBTopcrBo qbc cneqra.nrcrl BbB OAM l.i Apyrx npefirx(Hx ,Hcfl4Tyrr a crpaHara, Roxro ca nocoleHl, xaKTo l.t t(oHcyITaHTxTe. Pe3yrlarx nory,{eHlre pe3yrrar[ ca o6exruaxt B pe3ynrar Ha npaBrlHo noA6paHxre x npeqx3Ho l.i3nbnHeB{ MeroAxRx. B Ao6pe npeAcraBeHoro o6cbxAaHe Ha pe3y.[Tar[Te !t cbnocraB(aTa c Apyrx noAo6Hx x3c,leABaHl4' B Hay{HaTa .,llTepaTypa nponxqaBar pea,lHHTe nprHocr{ Ha AoKToparra c pa:pa6ouara xa To3x rpyA. llpuHocu Axcepraqnrra ,Ma 6e3cnopHx nprHocn 3a pa3Blrxero Ha eHAoAoHTlnra, or Koxro no-cbqecTBeHx ca: -lgetrrr$txaqna Ha MxKpoopraHx3Mrrre or rH(beKrxpaHnre xopeHoBl{ KaHaln npx naqxeHTx y Hac; -ycTaHoBFBaHe Ha 6XOIOntqHaTa nOHOCI.IMOCT Ha HOBOCb3AaAeHITe 6bIrapcR' Qorocexcl6uaraaropx Ha ocHoaara Ha qxH( x rar!!i; -r3cneABaHe ra e$erra Ha 0oro aKTxBxpaHara Ae3l1Hoexqhr (OAfl) c noane {orocercr6raauaaropu (Zn- I Ga {raaoqraxunr.r); - npowBaHe Ha reMneparypHxre npoMeHx Ha BbHuHaTa xopeHoBa noBbpxHocT npl OM crepMoBx3xoHHa xaMepa; -cpaBHxrerHo ,t3creABaHe eoeKrnBHoqEa Ha OM x aHTxMxHpo6H[f,T e+efi Ha Bllcoxo eHepfriHl,rrr Nd:YAG na3ep l,l rpenopbqBaHeTo ]tM Haro a.rrepHar]t8Hl aHTnMXKpO6Hn MeTOAI npn eHAoAoHTCXO neqeHle, (aKTO 14 CpaBHeHnero Ha eOeKTa }lM c x,acxqecHITe aHTxMltxpo6Hx xpxrxpaqn pa3rBopx ; -npoBeAeHxre r3crleABaHrn Ha HoBr4Te 6bnrapcxx 0oroceHc$6t tn3aropn , nonyqeHy[e pe3yrrar[, ca npeAnocraBKa 3a cepr]roxqxpaHero, npoE3BoAcrBoro ,t pa3peuraBaHeTo xM 3a npularaHe B eHAoAoHTCKaTa l{,rHtt'{Ha npaRTUXa. J, L, llpeqenxa aa trydnuxaquume u nutHun npunoc na doxmopoxma npeAcraBeH[ ca 3 ny6alxaqln cBbp3aHx c AxcepraqloHHaTa reMa Raro npn ABe oT TAX AOKrOpaHTbr e nbpBx aBTop. BIB Bpb3(a c ArcepraqxsTa ca HanpaBeH[ 5 Hay,{Hx cbo6qeHxf, (3 nocrepa rl 2 oparH}{ npe3eHraqllx) npx 4 or Koxro n.bpBr aBTop e AoxropaHTKara. A-p feoprneBa e r3Btplllxra pa6orara caMoqroirerHo l.l chc cbrpyAHxql l,t aa6oparopru, xolro ca (opeKTHo nocoqeHr. B Aemope$epam ABTopeoeparbr B 63 crpaHxqn, BMloqBaqx 5 ra6anql x 10 Olrrypx, orpa3sBa cbAbpxaHrero Ha Ahcepraq[BTa. [lpeAcraBeHx ca MeroAxre Ha r3cneABaHe, pe3yrrarr ]t o6cuxgare,raeo4l, npnHocx ,t ny6arxaqrr. ABTope$eparbr e qbo6paeet c arsnpreure l,t3l.tcxBaHlla. Kpumuuau ea6enetcxu u npenopbxu noBeqero xpxruqHxre 6eaexxr r.r npenopbKx ,Roxro 6nxa AaAeHx B npeABaplrenHara peqeH3xr ca B3err B npeABhA. He oAo6pf,BaM HaroxeHlire npaBxna B Qaxyarera ea pas4eanxero Ha Marep[artre or MeroAxre, Ha pe3yrrarxre - or ocr,xAaHero uM . AncepraHrbr 6x rpn6Bano Aa xMa npaBo Ha x36op 3a oQopranre Ha cBo, rpyA. AxcepraqxnTa e rBop{ecK(, a He cnlHAapTeH npoAyKT. SoxntoqeHue A[cepraqxoHHnrr rpyA Ha reMa Ae3xHoerqx, x ,, BtamoxHoc Ha ooro-affixBrpaHaTa [:rrDqBaHero Ha ND: YAG ,ra3ep 3a errM]rHtlpaHeTo Ha eHAOAOHTCKa?a MXKPOonOpa " e aKryanHa Hay,{Ha pa3pa6orKa, Korro l4Ma 3HaqeHre 6 3a MlHrqHara npaKTlKa. [locEBeHara qe.n e nocrxrHara c nraHlpaHero x h3nbnHeHrero Ha 6 ocHoBHn , 3 noA3aAa,{n. B pe3yrrar Ha npoBeAeHrre r3creABaHnn AoKropaHTxara npenopb'{aa nptuamHero Ha Qorocexcx6raraarop}t t{ Ha BxcoKo eHeprxiHxaT Nd:YAG ,a3ep RaTo anrepHarxBHli 14 Aon.brHxrerHlt MeToAl4 3a atumrxpo6xo aua4eficrere flpx eHAoAoHcRoro reqeHre Ha xHtbeKrltpaHn HopeHoBx RaHa.I14. Pe3y.nTaTxre or npoBeAeHxre r3cneABaHx, Ha HoBlre BoAHopa3Taop[Mx 6uarapcxu 0oroceHcx6nrn3aropl4 Ha ocHoBara Ha zn- x Ga Qrraaoqraunrr ca BaxHx 3a ceprroxqxpaHero x npox3BoAcr8oro xM 3a npnnaraHe a K,lrHltqHara eHAoAoHTl.tf,. npeAqraBeHxf,r rpyA, Ao6pe noApeAeH M oHarreAeH, e Aoka3arencrBo, ,{e AOKTOpaHTbT e oBIaAAn reopeT{qHxTe n npaKuqecKx yMeHxn 3a caMocrorTenHo nra|IpaHe n npoBexAaHe Ha SayqHx x3cleAaaHnr. Alcepraqnrra x 6o6pa3f,Bafixx ce c (p{Tepxrire 3a npxAo6nEaHe Ha o6pa3oaare,[Hara r Hayt{Ha cTeneH,Aotfiop' GuacHo 3aKoHa 3a OL{eHnBaiKx no AocroiHcrBo pa3BxaeTo Ha aKaAeMlqH[fl cbcTaB, [lpaBx.nHl1Ka 3a HeroBoro nputoxeHl/le ]i npaBxnHr(a Ha My-Coorn AaBaM no.[oxtiTerHa oqeHxa 3a AxcepraqxoHHxf, rpyA rpyA l,r y6eAeHo npeAlaraM Ha HarrHoTo xypn Aa npxcbAn Ha A-p LlBeTenrHa reoprueBa reoprxeBa o6pa3oBarerHara x Hay{Ha creneH ,AoKrop" no HaylHara cneqnarHocr repaneBTr,{Ha cToMarorort4, 03.03.01. 21.08.2015 r. PeqeH3eHr