course brochure - University of Arizona

Explore Tucson
One-half day has been allowed for relaxing or touring the
spectacular sites surrounding Tucson, which is part of the Sonoran desert. Activities could include jeep tours into the mountains,
a visit to the internationally acclaimed Arizona-Sonora Desert
Museum or Kitt Peak National Observatory, or a tram ride and
hike into Sabino Canyon. We will assist you in forming groups
interested in various excursions.
May in Tucson is warm (average high temperature is 90°) and
dry during the day but the desert rapidly cools once the sun
sets. Bring a sweater or light jacket for the conference room and
evenings. Tucson is located in a valley at an elevation of about 2500
feet. Phoenix is 100 miles to the north and Mexico is 70 miles to
the south. Tucson is serviced by numerous airlines
A special rate of $169.00 per night plus tax (the resort services
fee normally $20 per night is waived for our group) has been arranged. This cost is not included in the registration fee and each
attendee will be responsible for making his/her own hotel arrangements. Please call 800-937-8461 or 520-742-6000 before March
28, 2012, as rooms will only be held until that date or until the
block has been filled.
The Westin La Paloma is located about 20 miles north of the
Tucson International Airport. Transportation is available from
the airport via Arizona Stagecoach or by taxi. If you would like
to do sightseeing in the area or dine in many of the restaurants,
a car will be needed as Tucson
has limited public transportation. There are several rental car
agencies located at the Tucson
International Airport.
The objective of this course is to present the principles of pharmacokinetics and toxicokinetics on an
elementary yet sufficiently detailed level. The student
will be able to apply these principles in a practical
way in an industrial setting. Emphasis will be given to
a conceptual understanding. The groundwork begun
here will allow the student to further his/her own
specific assignments in these general areas. The course
is designed to introduce and integrate the principles
of pharmacokinetics, biopharmaceutics, toxicokinetics
and drug dynamics. These principles will be developed without the need for complex mathematical
formalism; when needed, the necessary mathematics
will be presented. The principles will be established
with the use of extensive examples from the literature
to illustrate the principles, solidify understanding of
the material and to illustrate the use of this information in the work environment. The course will promote better interdisciplinary understanding of basic
concepts essential for drug development.
principles of
PHARMACOKINETICS
& TOXICOKINETICS
for the
INDUSTRIAL SCIENTIST
The course enrollment will be limited in order to
allow more personalized attention and discussion of
specific problems or issues of interest to the students
and relevant to his/her activities.
The University of Arizona
College of Pharmacy
Continuing Education
PO Box 210202
Tucson, AZ 85721-0202
The course will be held in Tucson, Arizona at The Westin La
Paloma Resort & Spa, 3800 East Sunrise Drive, Tucson, Arizona
85718. The Westin La Paloma is set in the lush, high Sonoran desert and positioned within close proximity to the beautiful Santa
Catalina mountains. Giant saguaro cacti, rare native succulents,
wild flowers and songbirds are abundant in the area. Enjoy this
premier, full-destination resort with breathtaking views, Jack Nicklaus Signature Golf Course, tennis courts, swimming pool and spa
facilities. The atmosphere is strictly informal Southwestern.
Course Description
& Objectives
Ask us about On-Site Courses!
Course Location
Who Will Benefit
from the Course?
On-Site Courses...
are also a popular option. These courses are designed to meet
the specific needs of your organization. Please contact us to
request a brochure or discuss this option in more detail.
April 29 - May 4, 2012
The Westin La Paloma Resort & Spa
Tucson, Arizona
Four & One-Half Day
Intensive Course
in the form
of Lectures,
& Discussions
NON-PROFIT ORG.
U.S. POSTAGE
PAID
TUCSON, ARIZONA
PERMIT NO. 190
Complete information about Tucson dining,
accommodations, and excursions is available at
www.visitTucson.com.
This course will be valuable to individuals in the pharmaceutical,
chemical and cosmetic industries and those in governmental agencies
concerned with regulatory issues. In the pharmaceutical industry this
course will benefit those active in formulation research and development, preclinical and clinical professionals (pharmacology, toxicology, biochemistry, veterinary medicine, analytical chemists, clinical
research associates, clinical monitors) and those in regulatory affairs.
The course will be useful for those in the chemical industry who are
involved with metabolic or toxicologic research, risk assessment and
regulatory affairs. The course will also be useful for clinical chemists
involved in aspects of therapeutic monitoring.
course registration form
PHARMACOKINETICS
& TOXICOKINETICS
April 29 - May 4, 2012
Westin La Paloma Resort, Tucson, Arizona
on line registration available:
www.pharmacy.arizona.edu/pk2012
NAME ____________________________________________________________________________________________________________
DEGREE _________________________________________________________________________________________________________
TITLE ____________________________________________________________________________________________________________
ORGANIZATION _____________________________________________________________________________________________
DEPARTMENT _________________________________________________________________________________________________
ADDRESS ________________________________________________________________________________________________________
CITY ______________________________________________________________________________________________________________
STATE _____________________________________________________ ZIP ________________________________________________
WORK PHONE ________________________________________________________________________________________________
FAX _______________________________________________________________________________________________________________
EMAIL ___________________________________________________________________________________________________________
SPECIAL DIETARY REQUIREMENTS _________________________________________________________________
_____ Registration fee: $3200.00
_____ I will/ ___ will not attend dinner Monday evening
(included in registration fee)
_____ Guest - Monday dinner ticket(s) at $50.00 per guest
Please indicate method of payment:
___ Check made payable to the The University of Arizona Foundation
___ Visa
___ Mastercard
___ American Express
Card # ___________________________________________________________ Exp Date __________
(The UA Foundation will appear as the vendor on your statement)
Cardholder’s name as it appears on card
__________________________________________________________________________________________
Credit Card billing address if different from address above
__________________________________________________________________________________________
Registration
Information
To register for the course, please
complete and return the registration form with your payment.
Enrollment will be limited and
registrations will be accepted on
a first come basis. If delays are
expected in processing, please call
one of the numbers listed or fax us
your intent to attend and a place
will be held for you and/or your
colleagues. The cost of the course
is $3200 which includes all course
materials, reception, breakfast each
morning, four lunches, breaks,
and one dinner. Checks should be
made payable to The University of
Arizona Foundation.
Office of Continuing Education
The University of Arizona
College of Pharmacy
PO Box 210202, 1295 N. Martin • Tucson, Arizona 85721-0202
Fax: 520-626-2023
HENRY (HANK) J. PIENIASZEK, JR. received his Ph.D. from the University of
Arizona. He joined DuPont Pharmaceuticals in 1982 and when he left in 2002, he
was the Senior Director of the Clinical PK/PD and Biomarker Group. At DuPont,
he specialized in cancer, cardiovascular, CNS, HIV, metabolic diseases and transplantation. He has assisted in the development and approval of eight novel medicines
during his career: Apriso (ulcerative colitis, 11/08), Opana ER (moderate to severe pain,
6/06), BiDil (heart failure, 6/05), Innohep (LMWH, 7/00), Sustiva (HIV, 9/98), Bianda
(anticancer, 2/96), ReVia (alcohol dependence, 12/94) and Ethmozine (antiarrhythmic,
6/90). He has over 50 publications and he currently serves on the Journal of Clinical Pharmacology Editorial Board. He is a former governing Regent (1999-2004) of
the American College of Clinical Pharmacology (ACCP) and the Past-Chair of the
American Association of Pharmaceutical Scientists (AAPS), Clinical Pharmacology
and Translational Research Section (2002). He was elected as Fellow of ACCP (1991)
and of AAPS (1999). Dr. Pieniaszek is currently a consultant/service provider to the
pharmaceutical industry.
Note: Registration fees paid to The
University of Arizona Foundation
are not considered to be a taxdeductible gift contribution.
If not registering online, return registration to:
For More Information
Office of Continuing Education
PO Box 210202, Tucson, AZ 85721
Phone (520) 626-3020
Fax (520) 626-2023
www.pharmacy. arizona.edu
Above butterfly, above bird, above-right lightning
and lizard on outside panel are photos
by Scott Mayersohn.
MICHAEL MAYERSOHN, PH.D. is Professor of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona. He received the B.S. in Pharmacy
(Columbia University College of Pharmacy) and the Ph.D. in Pharmaceutics
(College of Pharmacy, State University of New York at Buffalo, with Dr. Milo
Gibaldi). He has spent his entire career in academia. He teaches undergraduate
and graduate courses in pharmacokinetics and toxicokinetics and he has won the
Teacher of the Year Award seven times at the College of Pharmacy. Michael has
published over 160 research papers and several book chapters on absorption and
drug disposition. His research activities have involved pharmacokinetic studies of
drugs in animals and phase 1-3 clinical studies in humans. He is a past member
of the USP Biopharmaceutics Committee and the FDA Advisory Committee for
Pharmaceutical Sciences.
“Dr. Mayersohn—Great teacher, very enthusiastic. Makes
hard concepts easier to understand through example.”
“Dr. Pieniaszek—Encyclopedic knowledge of drug development programs: significant industrial experience. Mike
and Hank compliment each other very well.”
- course participants
REFUND POLICY: A refund (less
$250.00 administrative fee) will be
available for cancellations received
in writing prior to March 30, 2012.
Due to commitments to vendors,
there will be no refunds after
that date.
Persons with a disability may
request a reasonable accommodation, such as sign language interpreter, by contacting the Office of
Continuing Education, 520-626-3020,
e-mail [email protected]. Requests should be made
as early as possible to allow time to
arrange the accommodation.
Instructors
continuinged@
pharmacy. arizona.edu
NATHAN J. CHERRINGTON, PH.D. is an Associate Professor in the Department
of Pharmacology and Toxicology at the University of Arizona. He received a B.S. in
Zoology from Brigham Young University and a Ph.D. in Toxicology from North
Carolina State University with an emphasis on xenobiotic metabolism in the laboratory of Dr. Ernst Hodgson. He then moved to the University of Kansas Medical
Center to pursue postdoctoral training in drug metabolism and disposition with Dr.
Curtis Klaassen. He has taught Drug Metabolism and Disposition, Systems Toxicology and Advanced Toxicology courses since joining the faculty at the University of
Arizona in 2002. Nathan has published over 60 original research papers and serves
on the editorial board of Drug Metabolism and Disposition, Toxicological Sciences,
Toxicology and Applied Pharmacology, and Journal of Molecular and Biochemical
Toxicology. He has served on numerous NIH study sections and international society committees. He was recently awarded the Achievement Award by the Society of
Toxicology at their 50th annual meeting. His current research emphasis includes the
effect of disease on an individual’s ability to metabolize and eliminate drugs, as well
as the role of drug transporters to selectively deliver drugs across biological barriers.
Course Outline
SUNDAY, April 29, 2012
Arrive in Tucson, Westin La Paloma Resort & Spa
“I enjoyed the input from colleagues/discussion during the lectures.
It was great that you both encouraged people’s insight and expertise.
The venue was excellent..”
- course participant
Registration/Reception 5:30 - 7:30 pm
MONDAY, April 30, 2012
7:30-8:30 am REGISTRATION AND BREAKFAST
8:30-9:30 Introduction to course and attendees
9:30-9:45 BREAK
9:45-12:30 Disposition, models and data analysis
12:30-1:30 pm LUNCH
1:30-3:30 Clearance concepts I
3:30-3:45 BREAK
3:45-5:00 Clearance concepts II
5:00-5:30 Review/questions
6:30 GROUP DINNER
WEDNESDAY, MAY 2, 2012
7:30-8:30 am BREAKFAST
8:30-9:00 Review/questions
9:00-11:00 Drug metabolism
11:00-11:15 BREAK
11:15-12:30 Bioavailability/bioequivalence
12:30-1:30 pm LUNCH
TUESDAY, MAY 1, 2012
7:30-8:30 am BREAKFAST
8:30-9:00 Review/questions
9:00-10:00 Illustration of clearance concepts
10:00-11:00 Non-compartmental data analysis
11:00-11:15 BREAK
1:30-3:00 Nonlinearity in absorption and disposition
3:00-315 BREAK
3:15-5:15 Pharmacodynamics (PK/PD)
5:15-5:45 Review/questions
THURSDAY, MAY 3, 2012
7:30-8:30 BREAKFAST
8:30-9:00 Review/questions
9:00-12:00 Special populations: elderly, pediatric, gender,
hepatic and renal diseases
11:15-12:30 pm Multiple dosing
LUNCH ON OWN
12:30-1:30 LUNCH
AFTERNOON AND EVENING FREE
1:30-3:30 Absorption I. In vitro considerations
3:30-3:45 BREAK
3:45-5:00 Absorption II. In vivo considerations
5:00-5:30 Review/questions
“Excellent course, instructors and staff!”
7:30-8:30 am BREAKFAST
8:30-9:00 Review/questions
9:00-10:30 PK/PD of large molecule drugs
10:30-10:45 BREAK
10:45-12:30pm Preclinical pharmacokinetic considerations
- course participant
“Wonderful course! Great venue and excellent learning
environment/class interaction.”
- course participant
“This was probably the most useful course I have taken.
It is very well taught.”
- course participant
FRIDAY, MAY 4, 2012
12:30-1:30 LUNCH
1:30-3:00 Allometry (species scaling)
3:00-3:15 BREAK
3:15-4:00 Review and summary
4:00 GRADUATION