American Acupuncturist_V64_Summer13
Transcription
American Acupuncturist_V64_Summer13
Acupuncturist The American Volume | Summer 2013 AAAOM’s Official Publication for Practitioners of Oriental Medicine Inside Acupuncture Improves Working Memory and Reduces Anxiety Clinical Therapeutic Effect of “Ji Liu Nei Xiao Pill” for Uterus Fibroid Case Study on Management of Benign Prostatic Hypertrophy SAR 2013 Conference A Study on Scientific Writing: The Materials and Methods Section V Chinese Herbal Products You Can Trust AT K AN, QUALIT Y IS A WAY OF LIFE Scientific Assurance Extensive Product Selection Satisfaction Guaranteed Practitioner Support Kan Herb Company Online MADE AND TESTED IN THE USA Kan Herbals Kan Traditionals Kan Essentials Chinese Modular Solutions Gentle Warriors Jade Woman/Jade Man Herbals Sage Solutions MycoHerb Kan Singles Alembic Herbals Volume | Summer 2013 The American Acupuncturist is published quarterly by the American Association of Acupuncture & Oriental Medicine (AAAOM) 9650 Rockville Pike Bethesda, Maryland 20814-3998 toll free 866-455-7999 fax 301-634-7099 email [email protected] www.aaaomonline.org Original Research Acupuncture Improves Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial Jason Bussell PhD, LAc © Copyright The American Acupuncturist 2013 ISSN: 1520-7714 Clinical Therapeutic Effect of “Ji Liu Nei Xiao Pill” for Uterus Fibroid Tang Ling, Wang DongMei, Gu HuiXia, Liu Li, Wang XanXia, He ZhiPing Beijing University of Chinese Medicine Translated by Doreen G.F. Chen, MD, CMD, LAc Resource Directory ACAOM—Accreditation Commission for Acupuncture and Oriental Medicine Selection of Clinical Research Abstracts Presented at the 2013 Society for Acupuncture Research Conference: Impact of Acupuncture Research on 21st Century Health Care Jennifer A. M. Stone, LAc 14502 Greenview Drive, Suite 300B Laurel, MD 20708 phone 301-313-0855 fax 301-313-0912 www.acaom.org Case Study CCAOM—Council of Colleges of Acupuncture and Oriental Medicine Perspectives 600 Wyndhurst Avenue, Ste. 112 Baltimore, MD 21210 phone 410-464-6040 fax 410-464-6042 www.ccaom.org NCCAOM—National Certification Commission of Acupuncture and Oriental Medicine 76 South Laura Street, Suite 1290 Jacksonville, FL 32202 phone 904-598-1005 fax 904-598-5001 email [email protected] www.nccaom.org SAR—Society for Acupuncture Research 130 Cloverhurst Court Winston Salem, NC 27103 phone: 336-306-6888 www.acupunctureresearch.org A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine Connie L. Christie, MA, Dipl OM (NCCAOM), LAc A Study on Scientific Writing: The Materials and Methods Section Jennifer A. M. Stone, LAc Society for Acupuncture Research 2013 Conference: Public Health Aspects Elizabeth Sommers, PhD, MPH, LAc Book Review Evaluating the Economics of Complementary and Integrative Medicine Reviewed by Elizabeth Sommers, PhD, MPH, LAc 3 From the Editor: Jennifer A. M. Stone, LAc 6 In Memoriam: Al Loren Stone, DAOM, LAc 7 AAAOM Board of Directors & Mission Statement 28 Index to Advertisers 29 Trudy McAlister Foundation 2013 Scholarships The American Acupuncturist 1 2 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 From the Editor Jennifer A. M. Stone, LAc Welcome to the summer 2013 issue of The American Connie L. Christie, MA, Dipl OM (NCCAOM), LAc. Christie provides Acupuncturist. We are very pleased to present our new feature, the an interesting and informative review of prostate problems from a English translation of a selected Chinese research paper, previously Western medical perspective that is a valuable resource for AOM published in the World Chinese Medicine Journal, titled “Clinical professionals who treat prostate issues. Details on more serious Therapeutic Effect of ‘Ji Liu Nei Xiao Pill’ for Uterus Fibroid.” In prostate problems that should be ruled out are discussed. addition, we include a report, “Acupuncture Improves Working In the spring issue of The American Acupuncturist, I wrote a Memory and Reduces Anxiety: A Report of a Randomized, short study on how to write a scientific discussion section for a Clinical Trial,” as well as an original case study, “Management scientific manuscript. In this issue, I have prepared a study on of Benign Prostatic Hypertrophy Using Acupuncture and Chinese writing a methods section for this kind of paper. In future issues, Herbal Medicine.” I will include a short informative study on additional parts of the We also present a report on the 2013 Society of Acupuncture scientific manuscript to serve as a resource for AOM students, new Research Conference that was held in April in Ann Arbor, Michigan. authors, and new investigators. These perspectives are available to The Conference was a great success! Researchers from at least the general public in our open access issues of the journal on the 20 different countries gathered together to present their findings AAAOM website, www.aaaomonline.org. and discuss current issues surrounding acupuncture research. The book we have chosen to review in this issue is Evaluating the Many editorial board members and peer reviewers who lend their Economics of Complementary and Integrative Medicine by Patricia services to The American Acupuncturist were in attendance. I have Herman, ND, PhD, reviewed by Elizabeth Sommers, PhD, MPH, LAc. prepared a short summary on a few selected abstracts from the oral Elizabeth’s expertise in public health makes her the perfect person presentations presented at the conference that I think will interest to review this book. She provides a valuable chart that compares our readers. different types of analysis, benefits, limitation and examples. The Chinese research paper, “Clinical Therapeutic Effect of ‘Ji Liu Nei Xiao Pill’ for Uterus Fibroid,” was translated into English by Doreen Chen, MD, CMD, LAc. It was originally published in the Elizabeth recommends the book as a valuable resource for AOM professionals. Thank you authors, peer reviewers, and our translator for their World Chinese Medicine Journal and written by Tang Ling, Wang contributions to this issue. We continue to welcome submission DongMei, Gu HuiXia, Liu Li, Wang XanXia, He ZhiPing from Beijing of articles at any time on research topics, case studies, literature University of Chinese Medicine, Dong Zhi Men Hospital, Beijing, reviews, and opinion papers by both established authors and China. The study reports on 60 cases of uterine fibroids collected first-time authors. When considering submission to the journal, randomly and divided into two groups, half in a Chinese medicine please refer to our Author Guidelines, www.aaaomonline. treatment group and the other half in the Western medicine org/?page=authorguidelines. If you have questions or need more treatment group. information, please contact Associate Editor Lynn Eder, leder@ Jason Bussell, PhD, LAc reports on “Acupuncture Improves aaaomonline.org. Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial,” which examines the impact of acupuncture on memory. Ninety subjects of varied ethnicity were recruited from Respectfully, local universities around the Chicago area and randomized into two Jennifer A. M. Stone, LAc groups. One group received an acupuncture treatment that was Editor in Chief, The American Acupuncturist tailored for reduction in anxiety and improved memory. The other group received a needleless placebo. Please take a look at the full text of this article to see the amazing results. Our case study, “Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine,” is written by The American Acupuncturist 3 CONSISTENT INSTANT AFFORDABLE www.ActiveHerbWholesale.com The American Acupuncturist is published quarterly, providing a professional venue for both published and first time authors. We welcome articles on clinical research, case studies, translated works, legislative issues, education developments, commentaries, literature reviews, and other current topics of importance to AOM. We value your AOM perspective. Please review the Author Guidelines at http://www.aaaomonline. org/?page=authorguidelines which also includes the submissions link. Editor in Chief Editorial Board Jennifer A. M. Stone, LAc John K. Chen, PhD, PharmD, OMD, LAc Evergreen Herbs Indiana University School of Medicine E-mail: [email protected] Managing Editor Michael J. Jabbour, MS, LAc E-mail: [email protected] Senior Editor Adam Burke, PhD, MPH, LAc Institute for Holistic Health Studies San Francisco State University Peter Johnstone, MD, FACR Indiana University School of Medicine Lixing Lao, PhD, LAc Center for Integrative Medicine University of Maryland Medical School Will Morris, PhD, DAOM, LAc Academy of Oriental Medicine at Austin Rosa N. Schnyer, DAOM, LAc School of Pharmacy, University of Texas at Austin Associate Editor Lynn Eder, MFA E-mail: [email protected] Senior Field Editor Janet Borges, MSTCM, Dipl Ac & CH (NCCAOM), LAc Misha Ruth Cohen, OMD, Dipl Ac & CH (NCCAOM), LAc UCSF Institute for Health and Aging Sherman Cohn, Esq. Georgetown University Law Center Kevin V. Ergil, MA, MS, Dipl OM (NCCAOM), LAc Finger Lakes School of Acupuncture and Oriental Medicine of NYCC John Fang, DAOM, LAc Graduate School of Traditional Oriental Medicine, Emperor’s College Steve Given, DAOM, LAc American College of Traditional Chinese Medicine Valerie Hobbs, Dipl OM & CH (NCCAOM), LAc Southwest Acupuncture College Jeannie Kang, MSTOM, DNBAO, DNBIM, LAc Serenity, TATC David W. Miller, MD, LAc East-West Integrated Medicine, LLC Karen Reynolds, MS, RN, LAc Balance Restored Center for Integrative Medicine Tammy Sajdyk, PhD Indiana University School of Medicine Elizabeth Sommers, PhD, MPH, LAc Boston University Naomi Takazawa, LAc, Licensed Moxibustionist Tokyo, Japan Dawn Upchurch, PhD, LAc UCLA School of Public Health S. Prasad Vinjamury, MD (Ayurveda), MAOM Southern California University of Health Sciences Jun Wang, PhD, DOM San Francisco State University The American Acupuncturist 5 In Memoriam: Al Loren Stone, DAOM, LAc With the untimely passing of Al Stone, DAOM, LAc on May 24th, the field of acupuncture and Oriental medicine lost a dedicated and revered pioneer, teacher, practitioner and advocate. Al’s accomplishments and reputation for excellence will long be felt and appreciated. Over the years, Al dedicated a significant amount of time and energy towards building the AAAOM presence, particularly in the areas of web technology and herbal medicine regulation. To honor Al and his work, AAAOM has created the Stone Memorial Fund. Its purpose is to support a prominent and informative web presence for our field. AAAOM thanks and recognizes Al for his life’s work, dedication, and persistence in promoting our profession. www.aaaomonline.org/StoneMemorialFund " Ê "7, Ê - Ê , - Innovative & Traditional Concentrated Chinese Herbal Formulas, Needles & Clinic Supplies, Books, Charts & Essential Oils. Summertime Formulas for Travel and Play* *For a complete description of these and our other formulas, give us a call or visit our website. Toll-Free 1.800.729.8509 Email [email protected] 6 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Find us on Facebook www.gfcherbs.com 2013 AAAOM Board of Directors Executive Committee Michael Jabbour MS, LAc President [email protected] Kimberley Benjamin LAc Vice President [email protected] Jane Yu MAOM, Dipl OM (NCCAOM), LAc, Secretary [email protected] John Barrett Dipl Ac (NCCAOM), LAc Treasurer [email protected] Jeannie Kang MS, DNBAO, DNBIM, LAc Immediate Past President [email protected] C. Daer Reid LAc [email protected] Ann Wang CMD (China), LAc [email protected] Jennifer Minor MA, MTCM, Dipl OM (NCCAOM), LAc [email protected] Joshua Saul Student Organization President [email protected] Directors-at-Large Public Directors American Association of Acupuncture and Oriental Medicine Mission Statement Hannah Seoh MPH, MS [email protected] Jay Sexton AB, MBA, JD [email protected] The American Association of Acupuncture and Oriental Medicine (AAAOM) is a national membership organization of 2013 AAAOM Committees/Chairs acupuncture and Oriental medicine (AOM) practitioners and supporters that serves to Committee Chair Email Conference Deborah Lincoln, MSN, RN, Dipl Ac (NCCAOM) [email protected] Education and Credentialing Michael Jabbour, MS, LAc [email protected] Essential Health Benefits Jeannie Kang, MS, DNBAO, DNBIM, LAc [email protected] Executive Michael Jabbour, MS, LAc [email protected] Finance John Barrett, Dipl Ac (NCCAOM), LAc [email protected] Good Preparation and Dispensing Kevin Ergil, MA, MS, Dipl OM (NCCAOM), FNAAOM, LAc Governance Jay Sexton, AB, MBA, JD Herbal Medicine Eric Buckley, DOM advocacy in our commitment to [email protected] Insurance Mark Evans, LAc facilitate access to the highest [email protected] Inter-Professional Standards William Hendry, DOM, LAc quality of healthcare in the [email protected] Media and Public Education Kari Auer, MA United States. [email protected] Membership Jane Yu, MAOM, Dipl OM (NCCAOM), LAc [email protected] Public Policy Jeannie Hoyt [email protected] advance the profession and practice of AOM. The mission of the AAAOM is to support our members and the AOM community through education, occupational resources, [email protected] media support, and legislative [email protected] The American Acupuncturist 7 Acupuncture Improves Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial By Jason Bussell PhD, LAc Jason Bussell earned his MSOM from the Midwest College Abstract and his PhD in acupuncture from the Guangzhou University Introduction: To investigate whether acupuncture can improve memory and reduce anxiety. Design, Setting, and Subjects: A two-group, randomized, single-blind study involving 90 undergraduate university students. Interventions: Subjects completed the State-Trait Anxiety Inventory (STAI) form Y-1 (State Anxiety, SA) and Y-2 (Trait Anxiety, TA). Then each subject laid on a treatment table for 20 minutes. The acupuncture group had needles inserted into select acupoints; control subjects did not. Subjects then completed the STAI form Y-1 again and also completed the Automated Operation Span Task (AOSPAN)—a computerized test of working memory. Main outcome measures: Performance on the AOSPAN and STAI scores. Results: Acupuncture group scored 9.5% higher than control on the AOSPAN Total Correct Score (65.39 vs. 59.90 p=0.0134) and committed 36% fewer math errors (2.68 vs. 4.22, p=0.0153). Acupuncture subjects also reported lower SA after intervention than control (26.14 vs. 29.63, p=0.0146). Conclusion: This acupuncture protocol improves working memory and reduces anxiety. of Chinese Medicine. He served three terms as president of the Illinois Association of Acupuncture and Oriental Medicine and is currently on the Illinois State Government’s Board of Acupuncture. Jason has authored The Asian Diet: Simple Secrets for Eating Right, Losing Weight, and Being Well, published by Findhorn Press. He is also the creator of Supplemental Herb Songs: A 2-CD Collection of Songs to Help Students and Practitioners Learn Herbal Formulas, published by CD Baby. [email protected] Keywords: acupuncture, working memory, anxiety, AOSPAN, STAI 8 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Introduction Innovation A recent study demonstrates that an acupuncture protocol can improve memory and test taking and reduces anxiety immediately after administration. The study report was published in the Elsevier Journal of Acupuncture and Meridian Studies1 and the findings were presented at the Society for Acupuncture Research 2013 conference. The full report can be viewed at http://www.jams-kpi.com. All prior research into memory has studied impaired human or animal subjects. This is the first study to examine acupuncture’s ability to improve memory in healthy subjects. All previous research investigated the effect of a course of acupuncture on memory. This is the first study to examine the effect of one single acupuncture treatment on WM. It is also the first to investigate the connection between acupuncture’s ability to improve memory and its ability to reduce anxiety. Working Memory Working memory (WM) was originally described by Baddeley and Hitch.2 WM is basically short-term memory plus attentional control. It is comprised of three constituent systems: the phonological loop, where people keep repeating information to themselves in their mental voice to keep it in their short-term memory; the visual sketchpad, where people keep information in their short-term memory by thinking about how it looks; and the central executive, which decides how much mental attention to devote to actively remembering this information and how much attention is devoted to performing other tasks.3 WM has been associated with predicting such diverse capabilities as reading comprehension,4 arithmetic calculation,5 note taking,6 language comprehension,7 learning a computer language,8 learning to spell,9 following directions,1 building vocabulary,1 writing,1 complex learning,1 and reasoning ability.1 WM capacity is correlated with aptitude in many areas. It is measured by Operation Span Task (OSPAN) tests such as the Automated Operation Span Task. Anxiety Impairs WM Anxiety has been shown to impair performance in math,5,15 reading,16 and OSPAN task measures of WM.17 Anxiety impairs test performance and can be a serious problem for students. According to the American Test Anxiety Association, up to 38% of students have performance impaired by anxiety. Students with high test anxiety score approximately 12 percentage points lower than their peers on school examinations.18 Reducing subjects’ anxiety should help improve their test performance. Acupuncture Reduces Anxiety Studies have shown that acupuncture can reduce many types of anxiety, including generalized anxiety,19 depressive anxiety,20,21 and pre-operative anxiety.22–26 Pilkington, Kirkwood, Rampes, Cummings, and Richardson27 conducted a review of the literature regarding acupuncture and anxiety. They reviewed hundreds of studies and found the consensus to be promising for many types of anxiety. However, they also noted that there is a need for further research. Hypotheses UÊÊÊ/ ÃÊ>VÕ«ÕVÌÕÀiÊ«ÀÌVÊV>ÊÀi`ÕViÊ>ÝiÌÞ° UÊÊÊ/ ÃÊ>VÕ«ÕVÌÕÀiÊ«ÀÌVÊV>Ê«ÀÛiÊ7°ÊÊÊ UÊÊÊ/ iÊ«ÀÛiiÌÊÊ7ÊÜÊLiÊVÀÀi>Ìi`ÊÜÌ ÊÌ iÊ reduction in anxiety. Methodology Participants: During 2011, 90 subjects of varied ethnicity were recruited from local universities around the Chicago area via solicitation flyers. Inclusion criteria was that all subjects must: be undergraduate university students aged 18-30; be willing to receive acupuncture; have not received acupuncture in the three months prior to testing; be free of any serious medical problems; not be taking any psychoactive medication; not be pregnant or breastfeeding; and be fluent in the English language. Subjects received financial compensation for their participation. All subjects were treated in accordance with the NIH guidelines for research on human subjects. Instruments and Measures: The State-Trait Anxiety Inventory (STAI) consists of two forms: Y-1 for state anxiety (SA) and form Y-2 for trait anxiety (TA). The STAI has shown test-retest reliability and external validity28 and is one of the most widely-used anxiety measurement instruments in the world.29 The Automated Operation Span Task (AOSPAN) is a computerized test of WM that has demonstrated good internal reliability and external validity.30 Subjects are presented with a math problem to perform in their head, and then they must answer the problem on the computer. After answering the question, they are shown a letter to remember for one second. Then they are presented with another math problem followed by another letter. After a set of between three and seven of these math-letter pairs, subjects are shown a recall screen and must use the mouse to select the letters they were shown in the correct order. The math-letter sets and recall screens are presented serially in sets of three to seven in each set, with a total number of 75 letters and math problems each. The AOSPAN Absolute Score and the Total Correct Score both reflect the accuracy of the letter recall. The Total Correct Score counts all correct letter responses, while the Absolute Score only gives credit for letters recalled correctly when the entire set is recalled correctly. For example, if a set has seven math-letter pairs and the subject recalls six of the letters correctly, the Total Correct Score would be six and the Absolute Score would be zero. The AOSPAN also monitors performance on the math problems. It provides a numerical score for the total number The American Acupuncturist 9 “Care was taken to reduce the likelihood that control subjects would know that they were in the control group. When control subjects were presented with the AOSPAN, they were told, ‘Now we will have you take the first memory test.’ This was intended to raise the possibility in subjects’ minds that they might still receive acupuncture and take the test again.” of math errors and subcategorizes the totally number into accuracy errors and speed errors (failure to answer in the allotted time).30 The AOSPAN can be understood as a test of how well subjects can keep information in the back of their minds while actively processing other tasks and vice versa. Variables The independent variable was whether or not the participant received acupuncture for 20 minutes while laying on a treatment table for 20 minutes. The dependent variables analyzed were: initial SA (SA1), SA after the variable period (SA2), TA, change from SA1 to SA2 ( SA), AOSPAN Total Correct Score, AOSPAN Absolute Score, AOSPAN Math Total Errors, AOSPAN Math Speed Errors, and AOSPAN Math Accuracy Errors. Procedure Subjects were randomized ahead of time into acupuncture and control groups with a computer randomization program (www. random.org). Each subject was tested individually and seen for only one appointment. At the start of the appointment, subjects had the study design partially explained to them. They were told, “You will fill out some self-evaluation questionnaires, take some computerized memory tests, and you may receive acupuncture at some point.” Then they completed demographic questionnaire and informed consent forms. All subjects completed STAI forms Y-1 and Y-2. After this, all subjects laid on a treatment table. Subjects randomized into the acupuncture group and then received acupuncture according to clean needle technique (CNT) from an experienced, licensed acupuncturist at: Sishencong (EXHN1), Shenting (GV24), Yintang (EX-HN3), Shenmen (Ht7), Neiguan (PC6), and Taixi (Kd3). All treatments were administered by the same acupuncturist. Sishencong (EX-HN1), Shenting (GV24) and Yintang (EX-HN3) were needled with DBC Spring needles size 15 mm long and 0.20 mm thick. Neiguan (PC6), Shenmen (Ht7), and Taixi (Kd3) were needled bilaterally with DBC Spring needles size 30 mm long and 0.20 mm thick. The needles were inserted with even method to the depths specified in the Manual of Acupuncture by Peter Deadman and Mazin Al-Khaf31 and were retained for 20 minutes. There was no requirement for needling sensation to be obtained. After 20 minutes, the needles were removed and disposed according to CNT. Acupoints were chosen in an effort to calm the spirit and improve cognition. According to the Manual of Acupuncture, Sishencong 10 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 (EX-HN1) benefits the eyes and ears, calms the spirit, and is indicated for treating poor memory. Shenting (GV24) benefits the brain and calms the spirit. Additionally, the GV channel travels to and through the brain. Yintang (EX-HN3) calms the spirit and is indicated to reduce anxiety and agitation. Shenmen (Ht7) calms the spirit, regulates and tonifies the Heart, and is indicated for poor memory, fear, and fright. Additionally, the Heart organ is the house of the spirit. Neiguan (PC6) is indicated for poor memory, apprehension, fear and fright. Taixi (Kd3) was chosen because of the kidney’s association with the marrow and brain and because its low position on the body balances the effect of all the points on the upper body. In this treatment, Tai Xi (Kd3) was chosen to ground the treatment and the patient’s consciousness.31 Subjects in the control group were instructed to lay on the same table for 20 minutes. The same acupoints were touched and swabbed with cotton and alcohol, but no needles were inserted into the subjects. They were not led to believe that they were receiving acupuncture at this point, but they were not certain that they would not receive acupuncture later in the session. The amount of verbal and physical contact was consistent between groups, as Finness et al. have shown that differences in these areas can establish a placebo effect and alter outcomes.32 Care was taken to reduce the likelihood that control subjects would know that they were in the control group. When control subjects were presented with the AOSPAN, they were told, “Now we will have you take the first memory test.” This was intended to raise the possibility in subjects’ minds that they might still receive acupuncture and take the test again. After this variable period, all subjects completed the STAI Y-1 again (to see if subjects were more relaxed than before the intervention) and then completed the AOSPAN. To motivate subjects to use their best effort, they were told that a strong performance on the memory tests would enter them into a drawing for a cash prize. This study protocol was approved by the Institutional Review Board of the National University of Health Sciences. Clinical Trial ID = NCT01492738. Statistical Analysis The unpaired t-test was used to compare mean values between groups and subgroups. Regression analysis was used to examine interactions between SA, TA, and all parameters of AOSPAN performance. Acupuncture Improves Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial Results Ninety subjects met inclusion criteria and participated. The control group had 46 subjects (22 males, 24 females) and a mean age of 21.3 years. The acupuncture group had 44 subjects (16 males, 28 females) and a mean age of 20.5 years. There were no significant differences in gender makeup or age between the two groups. Results are presented as Mean Value ± Standard Deviation. Results were deemed significant with a p-value < 0.05. There were no adverse effects reported by any participants. All tables are taken from the aforementioned article in the Journal of Acupuncture and Meridian Studies. STAI The STAI provided numeric values for: Initial State-level anxiety (SA1), Trait level anxiety (TA), and State-level anxiety after the variable period (acupuncture or rest, SA2). The difference between SA1 and SA2 was calculated and termed SA. There were no significant differences in SA1 or TA between groups. The mean SA2 was significantly lower in the acupuncture group vs. the control group (26.14 ± 4.5 compared to 29.63 ± 8.2, p=0.0146). STAI State-Anxiety Score After Intervention Figure 1: Mean State-Level Anxiety After Intervention (SA2) The values obtained for TA ranged from 23 to 63. Using a median split, subjects with TA below 43 were classified as Low-Anxious (LA, n=62) and those with TA at or above 43 were considered as HighAnxious (HA, n=28). Within the acupuncture group, the reduction in SA ( SA) was greater for those considered to be HA (9.93 ± 6.40, n=14) compared to those considered LA (6.53 ± 5.02, n=30), but this was not quite statistically significant (p= 0.0623). AOSPAN The AOSPAN provided numeric values for Total Correct Score of letter memory, Absolute Score of letter memory, Total Number of Math Errors, Math Speed Errors, and Math Accuracy Errors. The highest possible Total Correct and Absolute Correct score were each 75. Subjects who received acupuncture performed better than the control on the AOSPAN. The Total Correct Score for the acupuncture group was 9.5% higher than those in the control group (65.39 ± 7.38 compared to 59.70 ± 13.12, p=0.0134). Mean AOSPAN Absolute Score was 45.87 ± 18.36 in control group and 52.20 ± 14.28 in acupuncture group (p=0.072). For the subgroup of males, AOSPAN Absolute Score was 44.14 ± 16.73 in the control group (n=22) and 55.13 ± 15 in the acupuncture group (n=16, p=.044). The acupuncture group committed 36% fewer math errors than the control group (2.68 ± 2.3 vs. 4.22 ± 3.44, p=0.0153). The mean number of math speed errors was 1.24 ± 1.59 in the control group and 0.80 ± 1.3 in the acupuncture group (p=0.153). The mean number of math accuracy errors was 2.98 ± 2.52 in the control group and 1.89 ± 1.71 in p (p=0.0188). Figure 2: AOSPAN Total Correct Score P=0.0146 AOSPAN Total Correct Score Control Acu Control Acu (SA2 values for Control and Acupuncture group. Bars represent Standard Error of Measurement (SEM) of 1.21 and 0.67 for Control and Acupuncture groups respectively. Acupuncture group had 12% lower anxiety than Control group after the variable period.) Mean SA1 was 35.98 ± 7.26 in the control group and 33.75 ±7.14 in the acupuncture group (p=.146, not significant). Mean TA was very similar between groups: 38.46 ± 10.6 in the control group and 37.86 ± 10.39 in the acupuncture group (p=.789, not significant). The mean SA was -6.35 ± 7.49 in the control group and -7.61 ± 5.65 in the acupuncture group (p=0.33, not significant). (AOSPAN Total Correct Scores for Control and Acupuncture groups. Bars represent SEM of 1.93 and 1.11 for Control and Acupuncture groups respectively. Acupuncture group scored 9.5% higher than Control group.) The American Acupuncturist 11 Acupuncture Improves Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial “Taken as a whole, males performed worse than females on every measure of the AOSPAN. But when broken down into acupuncture and control groups, males who received acupuncture outperformed females on nearly every measure.” AOSPAN Total Number of Math Errors Figure 3: AOSPAN Total Number of Math Errors Control Acu Table 2: AOSPAN Performance by TA among Control and Acupuncture Groups (Mean) Absolute Correct P=0.0153 (AOSPAN Total Math Errors for Control and Acupuncture groups. Bars represent SEM of 0.51 and 0.39 for Control and Acupuncture groups respectively. Acupuncture group committed 36% fewer math errors than Control group) Regression analysis was performed. There were no significant correlations found between: SA1 and AOSPAN performance, TA and AOSPAN performance; SA2 and AOSPAN performance; SA1 and SA; nor between SA and AOSPAN performance. Other trends UÊÊÊÊ*ÀiÛÕÃÊÀiÃi>ÀV Ê >ÃÊà ÜÊÌ >ÌÊÃÕLiVÌÃÊÜÌ Ê } Ê/Ê«iÀvÀÊ worse on tests of WM.15,33,34 This study confirmed these results. Subjects with low TA outperformed subjects with high TA on all parameters of the AOSPAN; but that difference was much less pronounced in the acupuncture group. Table 1: AOSPAN Performance by TA (Mean) Absolute Correct Total Correct Total Math Errors Speed Errors Accuracy Errors LA (n=62) 50.45 (± 16.74) 63.44 (± 9.96) 3.19 (± 2.49) 0.92 (± 1.26) 2.27 (±1.93) HA (n=28) 45.68 (± 16.45) 60.36 4.07 (± 12.99) (± 3.96) 1.25 (± 1.86) 2.82 (± 2.75) Difference -4.77 (9.45%) -3.08 (4.8%) + 0.33 (+36%) + 0.55 (+.24%) + 0.88 (+27%) Using a median split, subjects with TA below 43 were classified as Low-Anxious (LA) and those with TA of 43 or above were classified as High-Anxious (HA). LA individuals, as a whole, outperformed HA individuals on every measure, although the results are not statistically significant. 12 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Total Correct Total Math Errors Speed Errors Accuracy Errors LA (n=32) 47.59 (± 17.84) 61.31 (± 11.53) 3.56 (± 2.37) 0.91 (± 0.10) 2.66 (±1.94) HA (n=14) 41.93 (± 19.59) 56 (± 15.99) 5.71 (± 4.92) 2.0 (± 2.35) 3.71 (± 3.47) Difference - 5.96 (-11.8%) -5.31 (-8.6%) + 1.86 (60.4%) + 1.09 (120%) + 1.05 (39.5%) LA (n=30) 53.50 (± 15.19) 65.70 (± 7.50) 2.80 (± 2.59) 0.93 (± 1.51) 1.87 (±1.87) HA (n=14) 49.43 (± 12.15) 64.71 (± 7.35) 2.43 (± 1.60) 0.5 (± 0.65) 1.93 (± 1.38) Difference -4.07 (-7.6%) -0.99 (-1.5%) -0.37 (-13.2%) -0.4.3 (-43%) + 0.06 (3.2%) This chart compares Control Group LA subjects to Control HA and compares Acupuncture LA to Acupuncture HA. The impairment in performance observed in HA subjects compared to LA subjects was much less for the Acupuncture group than for the Control Group, although this difference was not statistically significant. UÊÊÊ/ iÊ«ÀÛiiÌÊvÕ`ÊÊÌ iÊ>VÕ«ÕVÌÕÀiÊ}ÀÕ«ÊÜ>ÃÊÀiÊ pronounced for males than for females. Taken as a whole, males performed worse than females on every measure of the AOSPAN. But when broken down into acupuncture and control groups, males who received acupuncture outperformed females on nearly every measure. Acupuncture Improves Working Memory and Reduces Anxiety: A Report of a Randomized, Clinical Trial Table 3: AOSPAN Gender Differences (Mean) Absolute Correct Total Correct Total Math Errors Speed Errors Accuracy Errors Female (n=52) 49.12 (± 16.84) 62.71 (± 10.26) 2.96 (± 2.32) 0.78 (± 0.89) 2.17 (± 1.89) Male (n=38) 48.76 (± 16.75) 62.16 (± 12.10) 4.16 (± 3.72) 1.34 (± 1.98) 2.82 (± 2.59) Total math errors male vs. female p = 0.0638 Math speed errors male vs. female p = 0.0772 Why No Sham (Placebo) Group AOSPAN performance by females compared to males. As a whole, females outperformed males on every measure of the AOSPAN, although not to the point of statistical significance. Table 4: AOSPAN Performance by TA among Control and Acupuncture Groups (Mean) Absolute Correct Total Correct Total Math Errors “This research shows only the shortterm effects of one acupuncture treatment. Future study should investigate: A) how long these effects last and B) how much more effective a course of treatment may be compared to just one treatment.” Speed Errors Accuracy Errors Female Control (n=25) 47.46 (± 19.97) 60.58 (± 12.62) 3.04 (± 2.26) 0.83 (± 0.70) 2.21 (± 1.93) Female Acu (n=27) 50.54 (± 13.84) 64.54 (± 7.48) 2.89 (± 2.41) 0.75 (± 1.04) 2.14 (± 1.88) Difference + 3.08 (6.4%) + 3.96 (6.5%) - 0.15 (-4.9%) - 0.08 (-9.6%) - 0.7 (-3.2%) Male Control (n=22) 44.14 (± 16.73) 58.73 (± 13.83) 5.5 (±4.07) 1.68 (± 2.12) 3.82 (± 2.84) Male Acu (n=16) 55.13 (± 15.01) 66.88 (± 7.21) 2.31 (± 2.15) 0.88 (± 1.71) 1.44 (± 1.31) Difference + 10.99 (24.9%) + 8.15 (13.9%) - 3.19 (-58%) - 0.80 (-47.6%) - 2.38 (-62.3%) Absolute score for Male Control vs. Male Acu P=0.0442 This chart compares AOSPAN performance by Control females to Acupuncture females and compares Control males to Acupuncture males. The improvement in AOSPAN performance for subjects receiving acupuncture was more pronounced for males than for females. Sham acupuncture does not exist. Placebo acupuncture is not an inert intervention. The two most common methods for administering sham acupuncture are superficial needling or “off-site” needling, both of which have been shown via functional MRI to have measurable effects. Placebos are supposed to have no effect at all, but sham acupuncture does not meet this criteria. Some studies have shown that sham acupuncture is as effective as verum (true) acupuncture and that both are more effective than placebo medication.35–37 Other studies have shown that the addition of either verum or sham acupuncture to standard medication provides superior benefit than standard medication alone but that the addition of verum acupuncture affects greater benefit than sham.38,39 Others have shown that while both sham and verum may be helpful, they may work through different biomechanisms.40 At least one study even reported that sham acupuncture was more effective than verum.37 Clearly, these techniques are not inert. Lundeberg et al. reviewed the literature regarding “placebo” acupuncture and concluded that it does not serve to elucidate acupuncture’s effects but rather introduces a potential bias which interferes with understanding its true effects.41 Discussion This study shows that acupuncture improves memory and reduces anxiety but that those effects are not correlated. It was not the case that the subjects with the lowest anxiety performed best nor was it the case that those with the greatest reduction in anxiety performed best. These two effects were not related. This suggests that acupuncture improves performance in WM through another mechanism than merely reducing anxiety. This study validates previous research showing that acupuncture reduces anxiety and improves memory. This research is unique, however, in that it is the first study to show that one acupuncture treatment has a measurable improvement on WM. continued on page 32 The American Acupuncturist 13 Clinical Therapeutic Effect of “Ji Liu Nei Xiao Pill” for Uterus Fibroid By Tang Ling, Wang DongMei, Gu HuiXia, Liu Li, Wang XanXia, He ZhiPing, Beijing University of Chinese Medicine, Dong Zhi Men Hospital, Beijing, China Published in World Chinese Medicine, 2012,7(5) Translated by Doreen G.F. Chen, MD, CMD, LAc Doreen Guo-Fong Chen, MD, CMD, LAc received eight years of Western medical education in the U.S. and China. In 1960, she graduated from the advanced class for Western MDs to study CM assigned by the Chinese Ministry of Health. In 1980, Dr. Chen was a visiting scholar at the Department of Pediatric Cardiology of the New York Hospital. In 1985, Dr. Chen obtained the New York State acupuncture license and operated three clinics. Dr. Chen is a strong advocator for integrative medicine. She took the first and second term as the president of the United Alliance of NY Licensed Acupuncturists (UANYLA). She is a long-time supporter and member of AAAOM and is honorary chair of the Chinese Advisory Council of AAAOM. She is also a senior advisor to the World Federation of Chinese Medicine Societies. 14 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Uterus fibroid (UF) is an overgrowth of the smooth muscle on the uterus, which is considered as a benign tumor. It contains fibroid tissue and becomes hard. It is a commonly seen tumor in the female reproductive system,1 and its occurrence rate remains high2. It often causes heavy menstruation and a prolonged menstrual period3 that can affect a woman’s daily life. Meantime, modern Western medicine (WM) has applied use of anti-estrogen medication or surgical removal of the uterus, but this has not resolved the root of the problem and the chances of re-occurrence. In addition, side effects of the medicine and high medical expenses are a problem. Therefore, finding an effective, reasonable, and low cost therapeutic treatment is important and practical. In Chinese medicine (CM), there is no such diagnostic term as “uterus fibroid,” but it belongs to the gynecological category described as “Zhen Xia” (mass in abdomen), “Tai Xi” (morbid leukorrhea), “Beng Lou” (metrostaxis), etc. Professor Xiao ChenZong has stated his principle and strategy of treatment using CM for UF as ”Benefit the Qi; Remove the Stasis,” which is a combination strategy of nourishing and attacking, i.e., put the nourishing in the attacking, while putting the attacking on top of the nourishing. Prof. Xiao has developed a herbal formula in pill form called “Ji Liu Nei Xiao.” It has achieved a good therapeutic effect on UF and has been broadly used in China. In our hospital research clinic, we have studied 60 cases of UF patients from November 2010 to September 2011. The following is our report of the results: I) Material and Method: 1.1 Clinical material: The 60 cases of UF were collected randomly and divided into two groups. Thirty cases were in the CM treatment group and 30 cases were in the WM treatment group. Both groups were treated according to the standards for diagnosis and therapeutic effectiveness from both the WM national standards and the “the principle of clinical guidance in new products in CM.” These 60 cases had been clinically examined by gynecologists and examined by color Doppler ultrasound to measure the inner and outer size of the UF and to study the circulation flow image (CDFI). 1.2 In reference to the 2002 issue of “The Clinical Research Guidance to CM” and according to CM diagnostic standard, the establishment of diagnosis for UF was as follows: a) irregular menstruation, including delayed, prolonged, or abnormal period; b) fatigue and tiring easily; c) menstruation with dark color and blood clots; d) loose stool; e) tongue color dark red, tongue body fat coated with white or yellowish coating, and teeth marks on the side edge of the tongue; f ) pulse deep and threaded or sticky. A patient had to manifest 4 of these agreed items among the 6 items plus the ultrasound or Doppler exam to confirm a diagnosis of UF before their case could be included in the study. The age of the CM group ranged from 23 to 45 years old, averaging 40.2 yrs. The age of the WM group ranged from 19 to 44 years old, averaging 40.7 yrs. The course of treat- ment had to be at least eight weeks. The information collected from the two groups was not much different (P<0.05), which indicated its comparability. 1.3 Treatment method: The CM treatment group was given 6gm of the “Ji Liu Nei Xiao” pills (manufactured by Dong Zhi Men Hospital) twice a day. If the patient’s menstruation was too heavy during the period, she would stop taking the pills for a few days. One month constituted a course of treatment. Each group received three months of treatments. The WM treatment group was given oral Mefestone (manufactured by the Ju Su You Chow pharmaceutical company, no. 120090137) 0.5gm each time, three times a day (best taken one half hour before the three meals), also with a total treatment time of three months. 1.4 Standard for evaluation: Before and after the three month course of treatment of patients in each group, every patient was given a gynecological examination. This included color Doppler circulation flow image (CDFI) and a high sensitive color Doppler image exam to measure the size of the uterus and the size of the fibroid body (using formula 4 abc/3cm³ for calculation, and also using abc to indicate the 3 dimensions of the radius of the measurement). These were then graded into four results for record: 1) no change as ineffective, 2) fibroid shrunk <50% as effective, 3) fibroid shrunk >50% as significantly effective, 4) fibroid totally disappeared as cured.4 1.5 Statistical calculation: Double person double time calculation for input figures applied SPSS 13.0 statistic software method to calculate the P value, with double examination. If the P value was <0.05, this would be considered as statistically significant. II) Final Results: The comparison of the treatment results of the two groups was statistically significant (P<0.05). This indicated the CM treatment group has a better effective rate (see chart). Group cases cured CM Treatment 30 8 WM Treatment 30 4 * P value <0.05 x²=4.36 significantly effective no effect total effectiveness 18 4 86.67%* 15 11 63.33% Discussion “In the book Lin Shu (“The Origin of an Illness”), it is stated that anything accumulated at the beginning must be because the body itself was weak. Therefore, any outside intruder will come to attack.” UF is a commonly seen issue in women’s reproductive organs (90% in the uterus body, 8% in the uterus neck). Research has indicated that the occurrence and growth of the UF was closely related to the level of estrogen and progesterone.5 Most scholars believe that using anti-estrogen or suppressing progesterone was the main approach of treatment, especially the use of Mefestone, which, when combined with the PR in our body, could completely suppress the biological reaction of progesterone. Also, by suppressing the estrogen through the biofeedback mechanism of the axis of middle brain-pituitarysex gland, you could suppress the growth of the UF.6 The American Acupuncturist 15 Clinical Therapeutic Effect of “Ji Liu Nei Xiao Pill” for Uterus Fibroid That was the Western medical approach, but it did not solve all of the problems. There were still the issues of side effects, recurrence, and the high medical expenses. Although there were no diagnostic terms for UF, UF has, as previously indicated above, belonged to the CM category as “Zhen Xia,” “Tai Xia,” and “Beng Lou.” In the book Lin Shu (“The Origin of an Illness”), it is stated that anything accumulated at the beginning must be because the body itself was weak. Therefore, any outside intruder will come to attack. It starts from the outside layer of the body, then progresses to the inner layer through the vessels or channels(经络), then deeply further into the “Fu Chong (伏 冲),” then at the outside of the organs of the body, including the gastrointestinal, urinary, and reproductive organs, finally reaching the inter space of the origin “Mu Yuan”(募原). The theory of “the evil Qi invaded from the outer shallow layer then proceeds into the inner deeper organs” has its practical meaning and makes common sense. So in CM the earliest documentation of the pathogenesis of illness stated that “it is the accumulation of evil Qi due to the weakness of the righteous Qi.” The same book also states, “a strong healthy person has no accumulation of evil Qi, but when that person gets weak in his/her righteous Qi, then illness will happen” and “stasis blood accumulated will become a lump and mass, then eventually become like a rock (Zhen).” This often happens in women and especially applies to the menstrual period. The anger hurts the liver, the rebellion Qi causes blood stasis; worry and depression hurts the spleen and weakens the Qi flow that will cause stagnation of the blood. If the remaining blood does not clean up and remains in the body then from time to time it accumulates and builds up to become a lump or tumor. So this is the theory in CM for the pathogenesis of the UF. Professor Chen-Zong Xiao, based on his numerous years of clinical experiences and the theory for the pathogenesis of UF in CM, developed the “Ji Liu Nei Xiao” pills for the treatment of UF. His basic principle of his treatment is to nourish and strengthen the Qi and to activate the blood flow so as to resolve the stagnation of blood and ultimately to dissolve the fibroid. His strategy is to combine the nourishing in the attacking, while putting the attacking on top of the nourishing. Professor Xiao researched and developed this “Ji Liu Nei Xiao” pill for the treatment of UF, which has now clinically gained good results and has been popularized in China. The basic herbs in “Ji Liu Nei Xiao Pill 肌瘤内消丸” are: 鬼箭羽 Ramulus Euonymi 生牡犡 Raw Oyster Shell 生首乌 Polygonacese Nourish the blood, resolve swollen, dissolve lump. 荔枝核 Litchi Seed Move the Qi, dissolve lump 黄芪 Nourish the Qi, move the stagnation Astragalus Root 川牛夕 Achyranthes Root Connect to the Right People and Opportunities with NYCC’S CAREER OPPORTUNITIES DATABASE... 16 Move the blood, resolve stagnation; nourish kidney Combining these herbs can take care of the weakness and the strong. Treat the disease by looking into both its root cause and symptoms. References: 1. Liu XiuFong. Clinical observation of CM differential diagnosis in assistance to WM treatment in UF. Liao Ning Journal of CM. 2011;38(6):1160. 2. Wan Min, Observation of 30 cases of UF underwent radioactive knife surgery under the ultrasound guidance. Report from Bon Fu Medical College. 2007;32(4):449. FREE! For more information: PHONE: 1-315-568-3039 WEB SITE: www.nycc.edu } Dissolve blood stasis, nourish the Ying and 制鳖甲 Cocked Turtle Shell } Clean the heat THE CAREER CONNECTION Finger Lakes School of Acupuncture & Oriental Medicine of New York Chiropractic College Career Development Center Promote blood circulation, dissolve blood stasis, Soften the hard, resolve the lump 3. Dou Shao Li, Dian Jing, et al. Clinical Analysis of 46 cases of UF underwent electric knife surgery. China Journal of Endoscopy. 2011;17(8):888. Sell your Acupuncture Practice Hire an Acupuncture Associate/IC Sell Acupuncture Equipment Rent Acupuncture Office Space Send postings by: FAX: 1-315-568-3566 E-MAIL: [email protected] T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 4. Chen Quan Xing. Clinical Effectiveness of Mifistone with Gui-Zhi,Fu-Ling capsule in the treatment of UF. Report from Tai San Medical Hospital. 2009;30(3):209. 5. Xia L, Coon JS et al. Regulates Growth of Uterine Leiomyoma Smooth muscle cells. Reprod. Sci. 2010;17(9):791-797. 6. Gun Zong Hua. Clinical observation of small dosage of mifistone in the treatment of UF. Sang Dong Medicinal Medica. 2011;51(18):89. A Study on Scientific Writing: The Materials and Methods Section By Jennifer Stone, LAc, Editor in Chief A scientific paper is usually comprised of these sections: Abstract Introduction Materials and Methods Results Discussion/Conclusion Acknowledgments Literature Cited Scientific writing is direct and orderly. The materials and methods section structure should: ÊÊÊUÊÊÊÊDescribe in detail the materials used in the study and include all tools: needles, herbs, surveys and questionnaires. (It’s not necessary to include all questions in the questionnaire if it is a proven measure previously used in research (ex. SF-MPQ, FACIT, etc.) ÊÊÊUÊÊÊÊiÃVÀLiÊÌ iÊ Õ>ÊÃÕLiVÌÃ]Ê>}i]Êi}LÌÞÊVÀÌiÀ>]Ê`i}À>« VÃ]ÊiÌV° ÊÊÊUÊÊÊÊvÊÞÕÊ``Ê>Êwi`ÊÀÊÃÕÀÛiÞÊÃÌÕ`Þ]Ê«ÀÛ`iÊ>Ê`iÃVÀ«ÌÊvÊÌ iÊÃÌÕ`ÞÊÃÌi]ÊVÕ`}ÊÌ iÊ«ÀiVÃiÊV>Ì]ÊÌÜ]ÊÃÌ>ÌiÊ>`ÊVÕÌÀÞ°ÊÊ If an online internet survey was used, include details on who received the surveys, inclusion/exclusion criteria, how many surveys were sent out, how many were completed and returned, how many were included in the data analysis. ÊÊÊUÊÊÊÊvÊÌ iÊ>ÕÃVÀ«ÌÊÃÊ>ÊiÌ>>>ÞÃÃÊÀÊÀiÛiÜ]ÊVÕ`iÊÌ iÊÃi>ÀV Êi}iÃÊ>`ÊÃViÌwVÊ`>Ì>L>ÃiÃÊÌ >ÌÊÜiÀiÊÃi>ÀV i`Ê>`ÊÌ iÊ inclusion/exclusion criteria for the studies that were discussed in the results section. ÊÊÊUÊÊÊÊÝ«>Ê ÜÊÌ iÊ>ÌiÀ>ÃÊÜiÀiÊÕÃi`ÊÊÌ iÊÃÌÕ`Þ ÊÊÊUÊÊÊÊiÃVÀLiÊÌ iÊÀiÃi>ÀV Ê«ÀÌV°ÊVÕ`iÊ ÜÊÃÕLiVÌÃÊÜiÀiÊÀ>`âi`ÊiÝ°ÊÕLiÀÃÊ«Vi`ÊÕÌÊvÊ>Ê >ÌÊÀÊLVÊ randomization). Include controls, treatment, variables that were measured, etc. ÊÊÊUÊÊÊÊÝ«>Ê ÜÊÌ iÊ`>Ì>ÊÜiÀiÊViVÌi`]Ê ÜÊi>ÃÕÀiiÌÃÊÜiÀiÊ>`i]Ê>`ÊÜ >ÌÊV>VÕ>ÌÃÊÜiÀiÊ«iÀvÀi`Ê ÊÊÊUÊÊÊÊ-Ì>ÌiÊÜ V ÊÃÌ>ÌÃÌV>ÊÌiÃÌÃÊÜiÀiÊ`iÊÌÊ>>ÞâiÊÌ iÊ`>Ì> The materials and methods section should always be written in past tense and in 3rd person. The description of preparations, measurements, and the protocol should be organized clearly and chronologically. Only include information relevant to the description of the materials and methods. Do not include any personal thoughts in this section; only describe what took place. Personal thoughts should be reserved for the discussion section. A materials and methods section should clearly explain the details of the study so that another researcher can read the manuscript and replicate the study exactly. In acupuncture research, remember to describe what brand of needle was used including: manufacturer, length and gauge, points used, how the treatment was determined, depth of insertion, style of needling, length of time needles were retained, etc. Example: Six acupuncture needles, Seirin Corp., Shizuoka, Japan, No. 3(0.20) x 30mm were inserted bilaterally into acupoints San Yin Jiao (SP6), Zusanli (ST36), and Tai Xi (KI3) at a depth of 1.5cm and gently rotated until daqi was observed. Needles were retained for 20 minutes. Acupoints were chosen through consensus by a group of 4 TCM experts, each with over 20 years of TCM practice. When describing an herbal formula, include the formula name if it is a patent herb formula. Also include the brand, manufacturer, dose, and each individual herb included in the formula. Some writers choose to list the indications for the herbal formula or each herb or acupoint although it is not necessary. If a writer chooses to list indications, it should not be listed in the materials and methods section. Indications should be reserved for the introduction or discussion section. Remember, the materials and methods section is a description of exactly what was done and how it was done so another researcher can duplicate the protocol exactly. continued on page 36 The American Acupuncturist 17 Society for Acupuncture Research 2013 Conference: Public Health Aspects By Elizabeth Sommers, PhD, MPH, LAc As the acupuncture and Oriental medicine (AOM) profession evolves in the U.S. and internationally, so do the corresponding research paradigms. It was inspiring and gratifying to see the variety of approaches to research and evaluation presented at the April 2013 Society for Acupuncture Research International Conference held in Ann Arbor, Michigan. In addition to presentations on both clinical studies and other more advanced concepts concerning the mechanisms of acupuncture, the conference incorporated a variety of public health-related perspectives, such as studies of the economics of acupuncture, factors influencing utilization (e.g., transportation issues, sociodemographics, need for care), and comparative effectiveness research. These diverse approaches more fully inform us about the nature of acupuncture as it is practiced “on the ground” in clinical settings and in communities. Presentations spanned the spectrum of acupuncture research— from the cellular (micro) level to the population (macro) level. This diversity of perspectives gives us a more comprehensive understanding and appreciation of acupuncture. In addition to the ongoing process of continuous improvement of treatment, these innovative approaches to understanding and describing acupuncture lend themselves to the broader medical and public health community. Going beyond the randomized clinical trial paradigm, studies on utilization can edify us about who uses acupuncture and why they seek this type of treatment. Economic evaluations provide information for policymakers, insurers, and other third party payers. These types of studies enable health departments to better determine the cost benefits related to acupuncture. At a time when healthcare dollars are more scarce and hotly debated, evidence about cost savings associated with acupuncture is crucial. These types of approaches have been developed through health services research, which is based on principles of public health. Although public health is sometimes misinterpreted as charity for the poor, it is more appropriately viewed as being related to improving the general health and well-being of society. The three basic tenets of public health—access, affordability, and acceptability of care—are used as the bases for determining how to best study and evaluate any treatment or intervention. Health services research examines all levels of an intervention (effectiveness, acceptance, cost) in order to provide a thorough picture of evidence that can be used by policymakers. In his keynote speech, “The Elusive Nature of Facts and the Subtle Effects of Power: Why We Need More Than the Natural Sciences for Acupuncture Research,” Volker Scheid, PhD made an eloquent argument for appreciating the contributions of medical humanities to acupuncture research. His thesis supported the need for truly holistic and comprehensive investigation of the underlying assumptions and goals of research. In other words, just as we have learned the principles of traditional Asian medicine and how to use them in the clinical setting, we can further develop and refine our understanding by learning how to be better informed readers, consumers, and architects of research. A panel discussion entitled “Impact of Acupuncture Research on 21st Century Health Care” included remarks (Left to right): Angela Tu, Deborah Lincoln, Jennifer Stone, Doreen Chen, Joanna Zhang. Photo by Buffalo Child 18 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 from Kristen Huntley, PhD; Wayne Jonas, MD; Lixing Lao, PhD, MD; Volker Scheid, PhD and Claudia Witt, MD. Discussants reviewed a variety of perspectives that contribute to today’s understanding of acupuncture research. These perspectives range from federal (National Institutes of Health and National Center for Complementary and Alternative Medicine), public health, military medicine, epidemiology, and anthropology. Although issues such as these are sometimes confined to a certain niche at AOM conferences, Society for Acupuncture Research organizers effectively and strategically integrated public health concerns into the fabric of the conference. International colleagues in Europe, Canada, and Australia provide foundations and directions for further development of them. Some of these contributions were evident at this conference, making it truly visionary for our profession. Elizabeth Sommers, PhD, MPH, LAc is director of research and education at Pathways to Wellness in Boston, MA. She is on the faculty at Boston University School of Public Health in Health Policy and Management and co-chairs the American Public Health Association’s group on Complementary and Alternative Health Practices. She has published numerous papers on public health aspects of acupuncture. Areas of interest include acupuncture studies related to health economics, recovery from substance use, and promoting health for people living with HIV/ AIDS. She was guest co-editor for the 2013 public health issue of the European Journal of Integrative Medicine. (Left to right): Robert Davis, Helene Langevin, Ryan Milley, Rosa Schnyer, Deborah Lincoln, Jennifer Stone. Photo by Buffalo Child Enhancing the profession by– Protecting acupuncture scope of practice Increasing public and professional awareness Providing discounted CEUs on educational conferences Offering business support resources Providing discounts to AOM vendors Since 1981, AOM practitioners have fought for what our profession has achieved today. As a member of your national professional organization, you will be supporting our continued efforts. You sacrificed a lot for your right to practice; make those sacrifices mean something—advance the profession by joining today! Join the AAAOM today! aaaomonline.org 1-866-455-7999 The American Association of Acupuncture and Oriental Medicine offers you the opportunity to have all of this. The American Acupuncturist 19 Selection of Clinical Research Abstracts Presented at the 2013 Society for Acupuncture Research Conference: Impact of Acupuncture Research on 21st Century Health Care By Jennifer Stone, LAc, Editor in Chief Approximately 200 researchers representing over 30 countries gathered to present their data at the Society for Acupuncture Research 2013 International Conference: Impact of Acupuncture Research on 21st Century Health Care held this past April in Ann Arbor, Michigan. Thirty-two oral presentations were featured, and over 100 posters were presented. The following is a sampling of the abstracts of the oral presentations. Clinical Research Abstracts: Acupuncture in Patients with Seasonal Allergic Rhinitis Results of a Randomized Controlled Trial, presented by Benno Brinkhaus, Institute for Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin Brinkhaus and colleagues conducted this three group randomized, controlled trial involving 422 patients suffering from seasonal allergic rhinitis. The study interventions were acupuncture plus rescue medication (RM, Cetirizine) (n=212), sham acupuncture plus RM (n=102), or rescue medication alone (n=108). Acupuncture led to improvements in disease-specific quality of life and antihistamine intake after 8 weeks of treatment compared to sham acupuncture and rescue medication alone in the first and second year. A Randomized Comparative Effectiveness Clinical Trial of Acupuncture as an Adjunctive Therapy in Patients with Depression, presented by Lin lin Sun, Beijing University of Chinese Medicine, and colleagues Dr. Sun and colleagues examined whether acupuncture plus the antidepressant paroxetine is more effective than paroxetine alone in patients with depression. Eighty-eight patients were randomized into three groups: electroacupuncture (EA), EA + paroxetine (Paxil), and paroxetine alone. The results indicated that acupuncture as an adjunctive therapy for patients with depression may be both safe and more effective than pharmaceuticals alone. Management of Gulf War Syndrome Symptoms with Acupuncture: Report on Preliminary Findings of an Ongoing Waitlist Control RCT, presented by Lisa Conboy, New England School of Acupuncture Conboy and colleagues conducted a preliminary analysis of symptom improvement in GWI veterans associated with acu20 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 puncture treatment. A preliminary analysis of symptom improvement comparing baseline scores to 6 month data collection indicates statistically significant improvements in the severity of veterans’ self reported main (p<0.01) and secondary (p<0.009) complaints. How Acupuncturists and Physicians View the Presence of In-Patient Acupuncture Care at Beth Israel Medical Center: A Qualitative Phenomenological Study, presented by Basia Kielczynska, Beth Israel Medical Center, New York Kielczynska and colleagues surveyed the “living experience” of acupuncturists while they provided acupuncture inpatient care and interacted with medical staff in a hospital-based acupuncture fellowship program. Researchers discovered that (1) Acupuncturists were excited about integrative practice opportunities, disappointed about limited interactions with medical staff, creative in adjusting to restrictions of hospital setting, and ambivalent about clinical research opportunities; (2) Acupuncturists considered their in-patient care limited but effective, and they expressed pride in holism of their practice; and (3) Physicians’ support for acupuncture care depended more on the clinical results and patient satisfaction than on their understanding of the philosophy behind acupuncture or acupuncture clinical research, and different departments of the hospital represented distinct “cultures,” some of which were more receptive to acupuncture than others. Acupuncture in a Managed Care Program: Evaluating Clinical Outcomes, Member Satisfaction, and Costs of Care, presented by Elizabeth Sommers, Boston University School of Public Health Sommers and colleagues evaluated a community health center and clinic specializing in acupuncture partnered with a large managed care organization to determine whether acupuncture treatment might influence clinical outcomes and costs of care for patients referred for the following conditions: pain, headache, menstrual or menopausal symptoms, carpal tunnel syndrome. Preliminary results indicate that offering acupuncture in a community health setting is acceptable and desirable by patients and physicians. Favorable clinical and cost of care outcomes were observed in this ongoing project. Adjuvant Whole Systems Traditional Chinese Medicine Improved Fresh, Non Donor In Vitro Fertilization: A Retrospective Chart Review, presented by Lee Hullender Rubin, Oregon College of Oriental Medicine Data from records of 1,069 fresh, non-donor cycles from a private infertility clinic were reviewed. The main outcome measure was live birth beyond 24 weeks gestation. In this retrospective review of records, researchers found that whole systems TCM pre-treatment prior to ET and acupuncture on the day of ET significantly improved live births in fresh, non-donor IVF cycles. Selection of Clinical Research Abstracts Presented at the 2013 Society for Acupuncture Research Conference Basic Science Abstracts: Central Mechanism of Instant Analgesia Effect of Aupoints on Shao Yang Meridians to Migraine Patients, presented by Yang Jie, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine Jie and colleagues examined patients who matched the inclusion criteria and randomly divided them into 2 groups: Group A received acupuncture on the shaoyang meridian once (GB20, SJ5, GB34); Group B was a waiting list group. Positron emission tomography computed tomography (PETCT) was performed to detect the cerebral glucose metabolism among the 40 patients after the first administration of puncturing. Then the difference among them was analyzed by SPM2, which was used to discuss the central mechanism of instant analgesic effect of puncturing at acupoints. The researchers discovered that the effect of puncturing at the acupoints on the shaoyang meridian could influence the regions related with pain, including middle cingulate gyrus, posterior cingulate gyrus, insula, hippocampus, and parahippocampal gyrus. Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats is Corrected by Electroacupuncture, presented by Stefania Lucia Nori, Department of Pharmaceutical and Biomedical Sciences FARMABIOMED NANOMATES, University of Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy Diabetes was induced in rats by streptozotocin (STZ). One week after STZ, EA treatments were started and continued for three weeks. NGF and NGF receptors protein and mRNA, NGF signaling pathways and the presence of NGF-regulated transient receptor potential vanilloid receptor 1 (TRPV1) were analyzed in dorsal root ganglia (DRGs). NGF receptors expression and colocalization was analyzed in spinal cord and skin. Researchers found that STZ increased NGF and NGF receptors expression, activated c-Jun N-terminal kinase (JNK) and p38 kinase and increased TRPV1 in DRG; EA in diabetic rats decreased both NGF and NGF receptors, normalized JNK and p38 activation, decreased TRPV1 and activated the transcription factor Nf- B. Expression of p75 neurotrophin receptor was increased in diabetic skin, while receptor tyrosine kinase A was increased in the spinal cord. EA in diabetic animals counteracted both these STZ-induced deregulations. Effects of a Topical Chinese Herbal Formula TLSJ Gel for Bone Cancer Pain in Rats, presented by Lixing Lao, University of Maryland School of Medicine A bone cancer pain rat model was used to investigate the effects and mechanisms of the herbal analgesic gel Tong Luo San Jie (TLSJ) on bone cancer pain. The rat model was established by inoculating Walker 256 rat carcinoma cells directly into the right tibial medullary cavity of Sprague Dawley rats (150 -170 g); PBS tibial inoculation was used as control. Cancer-bearing rats were treated twice a day with external TLSJ gel (0.5 g/cm2/day) or inert gel for 21 days (n=10/group). Mechanical threshold and paw withdrawal latency (PWL) were respectively assessed with von Frey filaments and Hargreaves’ Method. The data demonstrated that TLSJ treatment significantly restored bone cancer-induced decrease of PWL and mechanical threshold compared to inert gel. It also decreased the level of blood serum ICTP and BAP and inhibited osteoclast activities. Doses of Caffeine Relevant to Dietary Human Intake can Inhibit the Acupuncture-Induced Analgesia, presented by Ari More, Universidade Federal de Santa Catarina, Brasil Recently, the role of adenosine receptors in acupuncture analgesia (AA) has been shown, and caffeine, one of the world’s most commonly consumed dietary ingredients, is an antagonist of these receptors. In this study, the post-incisional pain model was used to investigate caffeine’s influence on AA. Mice were treated with acupuncture needling after administration of acute or chronic of caffeine. We found that acute pre-administration of caffeine (10 mg/kg, i.p.) completely reversed AA in both types of acupuncture. In the chronic pre administration, we used two doses that mimicked the average daily caffeine consumption in Western countries and China. Interestingly, the “Western dose” of caffeine (70 mg/kg/ day) administered during eight days in the drinking water reversed AA, and the “Chinese dose” (4 mg/kg/day) administered during the same period did not. These results indicate that the use of caffeine can inhibit the analgesic effect of different forms of acupuncture. Also, our findings suggest that doses of caffeine relevant to dietary human intake levels could be a confounding factor in the context of acupuncture research. Effects of Electroacupuncture at Neiguan (PC6) on Blood Pressure in Myocardial Infarction Rats, presented by Haiping Deng, Shanghai University of Traditional Chinese Medicine, China Shanghai Research Center of Acupuncture & Meridian, China To observe the effects of electroacupuncture at Neiguan on blood pressure in myocardial infarction rats, male SD rats (weighing 250300g) were randomly divided into an electroacupuncture group, a model group, and a control group. In the electroacupuncture group and the model group, the myocardial infarction model was established by permanent ligation of the left anterior descending (LAD) of left coronary artery. In the electroacupuncture group, rats were treated 30 min/d for consecutive 5d with EA at both “Neiguan” after the day of the operation, 2-15 Hz, 1-4mA. ECG had been recorded before and after the operation and after the treatment. Artery catheterization method for measuring femoral arterial and right carotid arterial systolic pressure, diastolic pressure, mean arterial blood pressure, and pulse pressure was used. Results suggested that electroacupuncture at Neiguan plays a role in the improvement of systolic pressure, diastolic pressure, and mean arterial blood pressure of the right carotid artery in myocardial infarction rats. The American Acupuncturist 21 A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine By Connie L. Christie, MA, Dipl OM (NCCAOM), LAc Connie L. Christie, MA, Dipl OM (NCCAOM), LAc, and certified Rolfer® is the owner of Affinity Acupuncture and Rolfing in Spokane, WA. She specializes in women’s and men’s hormonal health and pain relief and rehabilitation. A graduate of California State University, Northridge, and Yo San University in Los Angeles, she will complete the Doctor of Acupuncture and Oriental Medicine at Oregon College of Oriental Medicine in August 2013. Contact info: [email protected]. Abstract Benign prostatic hypertrophy (BPH), otherwise known as benign prostatic hyperplasia, is an enlargement of the prostate, a condition that often occurs in aging men. In the United States alone, more than fifty percent of men over the age of sixty reportedly suffer from some symptoms of BPH, ranging from mild discomfort to intolerable pain and refractory urinary retention. This case study documents the use of acupuncture and Chinese herbal medicine to treat a 67-year-old male diagnosed with BPH and the distressing urinary symptoms of pain, straining, urgency, nocturia and impotence for two and a half years. The patient was diagnosed and treated for Liver qi stagnation and Kidney yin deficiency. The patient had positive results as documented by the “AUA Symptom Index for BHP.” This case study supports the premise that acupuncture and herbal medicine may be beneficial in reducing or alleviating these symptoms of BPH, treating both acute symptoms and the root patterns implicated in the disease. Further research is needed to investigate the role of TCM in the treatment of BPH. Keywords: benign prostatic hypertrophy, acupuncture, Chinese herbal formulas 22 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Biomedical Perspective Benign prostatic hypertrophy (BPH), otherwise known as benign prostatic hyperplasia, is defined as enlargement of the prostate. The condition of BPH refers to the histological proliferation of smooth muscle and epithelial cells within the prostate. The prostate grows throughout a man’s life with two main growth phases: the first during puberty and the second around the age of 25. This second growth phase can years later contribute to BHP.1 As the prostate enlarges, the surrounding tissue stops it from expanding and thereby applies pressure to the urethra. As the prostate changes, the bladder also undergoes changes, becoming thicker and irritated. There are a number of studies that have reviewed casualty factors for BPH. Some of these studies have suggested a hereditary component while others have suggested differences in race.2 A study performed in Sweden supports the hypothesis of a relationship between high insulin levels and metabolic syndrome with development of BPH.3 The role of hormones, specifically DHT (dihydrotestosterone), was examined in a study conducted in 2000.4 The functional androgen-signaling axis is essential to prostate development. Within this axis, DHT plays a role in normal prostate development and can contribute to pathologic growth in the aging male. According to the American Urological Association, BPH rarely causes symptoms before the age of 40, but more than half of men in their sixties and up to ninety percent in their seventies and eighties have some symptoms of it.2 BPH is the most common benign tumor in men and, although not necessarily life-threatening, the symptoms can range from mild discomfort to intolerable pain.2 In addition, it can be problematic if urine is retained, as this can cause bacterial growth and infection. Symptoms typically become more prevalent with age and appear as changes in urinary flow. Common symptomatology includes nocturia, straining to urinate, an interrupted or weak urinary stream and the feeling of incomplete bladder emptying. Urgency, leakage, and dribbling after urination also occur. Even a small amount of urine in the bladder can cause contraction and create urgency and frequent urination. Before arriving at a diagnosis of BPH, it is essential to rule out other diagnoses, including urinary tract infection, neurological disorder, stricture disease, and prostate or bladder cancer.2 To confirm the diagnosis of BPH, the following main diagnostic tools are utilized: 1) The American Urological Association Symptom Index, which is attached in Appendix 1, is not only a valuable diagnostic tool to evaluate obstructive and irritating voiding symptoms but also essential to establish a baseline prior to treatment. 2) Digital Rectal Examination (DRE) to determine the size and condition of the prostate gland. 3) Prostate Specific Antigen (PSA) Blood Test is performed to rule out prostate cancer. Current research debates the benefits of using PSA as a test of prostate cancer.5 4) Cystoscopy may also be performed to obtain information on prostate size, as well as the location and degree of obstruction. Biomedical treatment of BPH consists of watchful waiting when the symptoms are mild, i.e., a score of less than 7 on the AUA. When watchful waiting is insufficient, the drug finasteride has been shown to be effective in reducing symptoms of BPH.4 Ultimately, surgery is indicated in life-threatening circumstances such as refractory urinary retention, large bladder deverticula, or a sequelae to BPH of recurrent urinary tract infections, recurrent gross hematuria, bladder stones or chronic kidney disease.2 Incidentally, the 5 alpha-reductase inhibitors (finasteride) which reduce DHT have been the only pharmaceutical class to halt the BPH disease process by reducing prostate volume and improving symptoms.4 Recent studies are investigating the use of alpha blockers and 5-reductase inhibitors to manage BPH.4 Oriental Medicine Perspective Research with acupuncture has shown it to be beneficial in treating voiding issues associated with the prostate. One study hypothesized that acupuncture regulates the nerves related to the prostate.6 Several studies on treating chronic prostatitis/chronic pelvic pain syndrome with acupuncture confirm that acupuncture relieves voiding symptoms and improves quality of life.7,8 A double-blinded randomized control trial is currently underway to explore the efficacy of electroacupuncture at a specific point for mild and moderate BPH.9 This trial follows a pilot study that showed a reduction of the International Prostate Symptom Score (IPPS) and improvement of difficult urination in patients with BPH. Historically, benign prostatic hyperplasia, being a modern Western disease category, has not been treated by Chinese medicine. Instead, TCM focuses on the clinical patterns of urinary symptoms. BPH has been described and treated as Long Bi or urinary retention. It is often treated in stages of severity of urinary symptoms.10,11 The first stage is nocturia, discomfort in the peroneal region, and no residual urination. This is the Chinese disease categorization of Ye Niao Duo Zheng.10 The second stage, Niao Bi, is pronounced urinary obstruction with dysuria, residual urine, and actual prostate enlargement. The final stage, Lin Zheng, manifests as urinary incontinence and polyuria. Chinese herbal formulations are commonly prescribed for the first two stages.12 In general, use of Chinese herbal medicine is well documented for Long Bi.13 The three most common herbal treatment methods by modern Chinese doctors are to nourish the yin, clear heat, and eliminate qi stagnation.13 One correlative study found the majority of BPH symptom parameters to correspond to Kidney yin and yang deficiency and qi stagnation.10,11,15 BPH tends to be relapsing by nature. Therefore, several authors believe treatment should be separated into two distinct categories: acute exacerbations and chronic experience.10,11,15 Several studies in China have shown various Chinese herbal formulations to be effective in treating BPH in rats.16,17 One of the The American Acupuncturist 23 A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine The patient experienced occasional belching and had hemorrhoids and occasional hard stools, which loosened when he did yoga routinely. The patient engaged in Bikram yoga five times a week and had an energy level of 8/10, with 10 being abundant energy for the day. His urination was frequent and he had slight post-urination dribbling. The patient stated that he was sleeping well but was waking up twice nightly to urinate. He also said he was eating a balanced diet, did not consume alcohol, and drank two cups of coffee per week. Examination revealed a red tongue, no coat with a deep central crack, and several horizontal branches and swollen sides. His pulse was wiry and rapid on the right and slippery on the left. studies verifies the efficacy of Lui wie di huang tang (Rehmannia Six decoction) in treating BPH in rats, of which a variation is used in this case study.18 Another study, comparing the use of formulations to treat Kidney deficiency patients and patients with blood and phlegm stasis, found that both approaches decreased the size of the prostate gland.19 Methods Case History: A 67-year-old male sought treatment in June 2012 for the following symptoms: hesitant, urgent and painful urination that included straining and frequency. He also complained of occasional impotence. He reported that these symptoms had been occurring for two and a half years and had been getting worse for the past year. In addition to the symptoms just indicated, the patient reported that he had been under severe distress in the three months prior to seeking treatment due to a job loss and marital disharmony. The patient appeared angry and frustrated, with a dry, withered face. The patient presented with a diagnosis of BPH from his physician based on a DRE. The patient weighed 153 lbs and was 5’10.” He reported no serious injuries and only one surgery, a vasectomy, 20 years prior. He was not on any medication except an over the counter nutritional supplement for prostate and kidney health that he had been taking for the past year. The patient stated he saw no improvements while taking the supplement but continued taking it for the duration of his treatment. TCM Diagnosis and Treatment This patient’s TCM diagnosis was Liver qi stagnation and Kidney yin deficiency with some phlegm and blood stasis. Liver qi stagnation was indicated by urinary blockage, the patient’s swollen tongue sides, wiry pulse, stressful lifestyle, and angry mannerisms. Kidney yin deficiency was evident in his dry skin and stools, withered face, red and coatless tongue with deep cracks, frequent scanty urination, dribbling of urine, and micturition stops and starts. Blood stasis was reflected in age in general, his wiry pulse, and prostatic hypertrophy. Phlegm stasis was manifested as enlarged prostate. In general, the etiology of this patient’s patterns was from emotional frustration and aging. Bikram yoga, performed in a room heated to approximately 105°F (40.6°C), had further depleted his yin. Treatment principles for this patient were to soothe the Liver and tonify the Kidney yin, while invigorating the blood, resolving phlegm, softening hardness, and opening the water passages. Table 1. Acupuncture Treatment Point Function Depth Needling method Note Yintang calm the shen 0.3 cun reinforcing method Hegu LI-4 harmonize the yin, move the qi 0.5 cun reducing method Zhongji CV-3 benefit urination, stop dribbling and regulate the lower jiao 1.5 cun reinforcing method angle needle toward root of penis Guanyuan CV-4 tonify the Kidneys and strengthen yin 1.0 cun reinforcing method angle needle toward root of penis Sanyinjiao SP-6 tonify the Spleen, Liver and Kidney yin and move the blood 0.5 cun reinforcing method Taixi KI-3 nourish Kidney yin 0.5 cun reinforcing method Taichong LV-3 soothe the Liver, drain the Liver channel, invigorate the blood and resolve pain 0.3 cun reducing method ZulingQi GB-41 promote the smooth flow of qi 0.3 cun reducing method Qianlieyanxue (extra point, prostate point) empirical point for benefiting the prostate 1.5 cun even method, angle 45° inward 24 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 15 located midway between huiyin CV-1 and the anus A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine The patient received nine acupuncture treatments: one per week for 6 weeks and then one treatment every 3 weeks for 3 sessions, with needles retained for 30-40 minutes. The needles used were 0.16x30mm, spring type, Acuzone brand, Korea. Table 1 describes the points needled and methods used.20 After two weeks of acupuncture, the patient was prescribed an herbal formula (Formula One) for six weeks to reinforce the acupuncture treatment and assist with the branch symptoms of pain, straining, urgency, and weak urinary flow. Table 2 presents this formula, modified from a formula created by Yan De-Xin for qi stagnation and blood stasis.11 Chuan lian zi (Fructus Toosendan) was substituted for chen xiang (Lignum Aquilariae Agallochae) and qing pi (Pericarpium Citri Reticulatae) for chen pi (Pericarpium Citri Reticulatae) because of the stronger Liver pattern in the patient. Dong kui zi (Semen Abutilonis Seu Malvae) and kai xin guo (Semen Pistachionis) were omitted because they were unavailable and che qian zi (Semen Plantaginis) was added to further strengthen the effects of promoting urination, clearing heat, and resolving dampness. Table 2. Formula One (focus on branch treatment) Herb Rationale Chuan lian zi (Fructus Toosendan) 3% regulates Liver qi, relieves pain Qing pi (Pericarpium Citri Reticulatae) 6% regulates Liver qi, breaks up qi stagnation Dang gui wei (Radix Angelicae Sinensis tail) 9.4% nourishes and invigorates the blood and directs it downward Huai niu xi (Radix Chyranthis Bidentatae) 9.4% tonifies Liver and Kidneys, invigorates the blood and directs it downward Wang bu liu xing (Semen Vaccariae Segetalis) 9.4% invigorates the blood, transforms stasis and softens hardness Shi wei (Folium Pyrrosiae) 16% promotes urination, dissolves phlegm Hua shi (Talcum) 9.4% promotes urination, clears heat, resolves dampness Mu dan pi (Cortex Radicis Moutan) 9.4% cools and invigorates the blood, disperses stasis, clears heat Shan zhi zi (Fructus Gardenia Jasminoidis) 9.4% drains damp-heat downward, sedates fire, relieves irritability Tao ren (Semen Pruni Persicae) 9.4% invigorates the blood, removes stasis, moistens the intestines After six weeks on Formula One, the patient’s herbal prescription was then changed. A second formula, Formula Two, a modified variation of zhi bai di huang tang (Anemarrhena, Phellodendron, and Rehmannia decoction) described in Table 3, was prescribed to treat the patient’s root disharmony by nourishing the kidney yin and soothing the Liver.21 This patient has a Liver constitution and is prone to Liver qi stagnation. Liver qi stagnation accumulates damp phlegm. Along with his age, this stagnation had generated heat and contributed to consuming his yin. Kidney deficiency is known to be the root cause of BHP because it results in the failure to transform and transport fluids in the lower jiao. Furthermore, the deficient heat cooks and thickens the fluids making it increasing more difficult to transform and eliminate them thereby leading to accumulation of dampness and phlegm enlarging the prostate.13 Table 3. Formula Two (focus on root treatment) Herb Rationale Sheng di huang (Radix Rehmanniae nourishes the yin and blood, cools the blood and tonifies the Kidneys Shan Zhu Yu (Fructus Corni Officinalis) 10.2% tonifies the Liver and Kidneys Shan Yao (Radix Dioscoreae Oppositae) 10.2% strengthens the Spleen, stabilizes the Kidneys and nourishes the essence Fu ling (Sclerotium Poriae Cocos) 7.7% strengthens the Spleen and drains dampness Mu dan pi (Cortex Moutan Radicis) 7.7% cools the blood and moves blood stasis Ze xie (Rhizome Alismatis Orientalis) 7.7% regulates water passage Zhi mu (Radix Amenarrhenae Asphodeloidis) 5.1% nourishes the yin, generates fluids, clears deficient heat Huang bai (Cortex Phellodendri) 2.6% clears deficient heat and dries dampness Chai hu (Radix Bupleuri) 7.7% moves Liver qi, eliminates stagnation Xiang fu (Rhizome Cyperi) 7.7% moves Liver qi, eliminates stagnation Wang bu liu xing (Semen Vaccariae Segetalis) 7.7% invigorates the blood, transforms stasis and softens hardness Yin yang huo (Herbaa Epimedii) 5.1% tonifies the Kidneys and boosts the yang The American Acupuncturist 25 A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine Both formulas were composed of KPC herbal granules with a standard 5:1 concentration. The patient was advised to take 5 grams twice per day, dissolved in 8 ounces of boiling water, once after breakfast and again after dinner. To stop consuming his yin, the patient was advised to stop or greatly curtail his Bikram yoga practice. He was also advised to walk in the woods and practice simple deep breathing exercises to manage his stress. Results This case study demonstrated generally positive results. The patient’s score on the “AUA Symptom Index for BHP” went from an indicated IPSS of 32 (severe symptoms) to a 7 (mild symptoms) and his impotence was resolved. The patient reported less pain and better erectile function by the second acupuncture treatment. At that time, the first herbal formula was prescribed. The patient continued to report symptomatic relief. By the third week of acupuncture treatments, (a week into his herbal formula) he reported no nocturia, little straining, and a stronger urination flow. After another two weeks receiving both treatments, the patient related that he had less urgency to urinate and that about half the time he felt that his bladder could completely empty. After six weeks, due to limited funds, the patient cut back on his weekly acupuncture treatments and began receiving treatments only once every three weeks. At that time, while using the formulas but with reduced acupuncture treatments, he continued to report improvement in his urinary symptoms. However, he started to complain about signs of erectile dysfunction again. After three prescriptions (6 weeks into treatment) of Formula One, the most severe symptoms of painful, hesitant, urgent, straining and frequent urination had subsided. The patient’s prescription was then changed to Formula Two. After one month on Formula Two, the patient continued to report minimal urinary discomfort and stated that he no longer experienced impotence. Regarding his chief complaints, this patient reported that he experienced satisfactory resolution. Following the primary course of treatment, it was recommended that the patient continue on Formula Two and be evaluated every six weeks. He was advised that if he experienced another acute episode of urinary discomfort, he should return to Formula One until it subsided. The patient was also instructed to be mindful of how he allowed external events to affect him internally and to continue to engage in stress management techniques. Discussion / Prognosis This case study documents and further supports success in an area where biomedicine offers no treatment besides watchful waiting, drugs, and surgery. Acupuncture and Chinese herbal medicine are demonstrated herein as effective for the management of the acute symptomatic stage of BPH and suggest an alternative to biomedicine for long term management. This study demonstrated 26 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 a significant resolution by IPPS standards of the most troublesome symptoms, including pain, a weak, straining and hesitant urinary stream, incomplete emptying of the bladder, and nocturia. The patient’s baseline IPPS before treatment was 32—severe and requiring medical intervention, with signs and symptoms of urinary distress over a one month period as defined in Appendix 1. The patient reported that the over the counter nutritional supplement for prostate and kidney health he had been taking for the past year had produced no symptomatic relief. It was therefore not considered a variable in the treatment protocol. Since he had purchased a large supply, he continued with the supplement in lieu of disposing of it. The patient’s post-treatment score of 7 after 3 months of treatment with acupuncture and Chinese herbal formulas showed great improvement over the initial evaluation per the IPPS index. The patient’s biomedical status went from needing intervention in the form of drugs or surgery to watchful waiting. This case study indicates that acupuncture and Chinese herbal medicine may relieve the disturbing symptoms of BPH and further supports the premise that acute symptoms and root patterns are not separate but intertwined. Success was achieved by treating acute exacerbations separately from the more chronic symptoms. Since BPH tends to be relapsing by nature, a patient must be committed to long-term vigilance and treatment. In this case, a strong formula was used to focus on the branch urinary symptoms and, once those subsided, the formula was changed to deal with the patient’s constitution and root disharmony of Kidney yin deficiency and Liver qi stagnation. In addition, by treating the patient’s Liver qi stagnation and Kidney yin deficiency, he once again had normal erectile function. The patient’s positive response to treatment contributed to a positive prognosis as did the fact that he was highly compliant with his treatment plan. The patient’s overall health, as reported on his intake forms, supports a history of good Kidney jing. He has not suffered from serious ailments or diseases. He has led a healthy lifestyle, eats and sleeps well, and consumes limited alcohol and caffeine. He has found acupuncture and herbal remedies to be successful and he was compliant. Conclusion This case study presents further optimistic results for treating BPH with acupuncture and Chinese herbal formulas and could be used as a reference for other practitioners treating BPH. The patient achieved significant resolution of urinary symptoms and restoration of his erectile function. Further research is recommended to investigate and document the role of Chinese medicine in the treatment of benign prostatic hypertrophy. A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine Appendix 1 The AUA Symptom Index for BHP and the Disease-Specific Quality-of-Life Question Reprinted from the Journal of Urology (1992), 148(5), Barry, M. J., Fowler Jr, F. J., O’Leary, M. P., Bruskewitz, R. C., Holtgrewe, H. L., Mebust, W. K. and Cockett, A. T. (The Measurement Committee of the American Urological Association), ‘The American Urological Association Symptom Index for Benign Prostatic Hyperplasia’, pp. 1549-1557. (c) American Urological Association, 1992. Reproduced with permission. Patient name: __________________________________ DOB: _______________ ID: _______________ Date of assessment: _____________________ Initial Assessment ( ) Monitor during: ___________________ Therapy ( ) after: ___________________ Therapy/surgery ( ) ______________________ AUA BPH Symptom Score Not at all Less than 1 time in 5 Less than About half half the time the time More than half the time Almost always 1. Over the past month, how often have you had a sensation of not emptying your bladder completely after you finished urinating? 0 1 2 3 4 5 2. Over the past month, how often have you had to urinate again less than 2 hours after you finished urinating? 0 1 2 3 4 5 3. Over the past month, how often have you found you stopped 0 and started again several times when you urinated? 1 2 3 4 5 4. Over the past month, how often have you found it difficult to postpone urination? 0 1 2 3 4 5 5. Over the past month, how often have you had a weak urinary stream? 0 1 2 3 4 5 6. Over the past month, how often have you had to push or strain to begin urination? 0 1 2 3 4 5 7. Over the past month, how many times did you most typically get up to urinate from the time you went to bed at night until the time you got up in the morning? 0 1 2 3 4 5 Total Symptom Score: IPSS Score: 0-7: Mild symptoms 8-19: Moderate symptoms 20-35: Severe symptoms The Disease-Specific Quality-of-Life Question (bother score): “If you were to spend the rest of your life with your urinary condition just the way it is now, how would you feel about that?” Delighted (0); Pleased (1); Mostly satisfied (2); Mixed (3); Mostly disappointed (4); Unhappy (5); Terrible (6) Treatment Decisions: IPSS 7, or no bothersome symptoms: watchful waiting IPSS 8: discuss treatment options; consider referral to Urology for further testing The American Acupuncturist 27 A Case Study on the Management of Benign Prostatic Hypertrophy Using Acupuncture and Chinese Herbal Medicine References 1. Isaacs JT. Etiology of benign prostatic hyperplasia. European Urology. 1994;5:6-9. 2. Meng MS, Stoller M, Walsh T. Urologic disorders: Benign prostatic hyperplasia. In McPhee, Current Medical Diagnosis and Treatment, 50th ed. (pp. 921-926). New York, NY: McGraw Hill Lange, 2011. 3. Harmarsten J, Hogsted B. Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia. Blood Pressure. 1999:29-36. 4. Bartch G, Rittmaster RS, Klocker, H. Dihydrotesterone and the concept of 5-alpha reductase inhibition in benign prostatic hyperplasia. European Urology. 2000;37:367-380. 5. Barry, M. Clinical practice: Prostate-specific-antigen testing for early diagnosis of prostate cancer. New England Journal of Medicine. 2001;344(18):1373-1377. 6. Yang Y, Jingli K. Clinical studies on treatment of chronic prostatis with acupuncture and mild moxibustion. Journal of Traditional Chinese Medicine. 2005;25(3):177-181. 7. Chen R, Nickel, JC. 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Chinese Journal of Integrative Medicine. 2012;18(11):824-830. 17. Huang YP, Du J, Hong ZF, Chen ZQ, Wu JF, Zhao JY. Effects of kangquan recipe on sex steroids and cell proliferation in rats with benign prostatic hyperplasia. Chinese Journal of Integrative Medicine. 2009;15(4):289-292. 8. Rosted P. Chronic prostatitis/chronic pelvic pain syndrome and acupuncture: A case report. Acupuncture in Medicine. 2007;25(4):198-199. 18. Shin IL, Lee MY, Ha HK, Seo CS, Shin HK. Inhibitory effect of yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats. BMC Complementary Alternative Medicine. 2012; 20(12):48. 9. Wang Y, Liu Z, Yu J, Ding Y, Liu X. Efficacy of electroacupuncture at zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: Study protocol for a randomized controlled trial. Trials. 2011;12:211. 19. Xie JS, Shen ZY, Wang WJ. Clinical study on comparison of tonifying kidney replenishing vitality and removing blood stasis and resolving mass in the treatment of prostatic hyperplasia. Zhonghua Nan Ke Xue. 1994;14(9):519-521. 10. Lin A. A Handbook of TCM Urology & Male Sexual Dysfunction. Boulder, CO: Blue Poppy Press, 1992. 20. Deadman P, Baker K, Al-Khafaji M. A Manual of Acupuncture. Journal of Chinese Medicine Publications, 1998. 11. Yan DX. Aging and Blood Stasis, A New TCM Approach to Geriatrics. Boulder, Colorado: Blue Poppy Press, 1995. 21. Bensky D, Barolet R. (1990). Chinese Herbal Medicine Formulas & Strategies. Seattle, WA: Eastland Press, 1990. Thank you AA Advertisers! In the same way that your business depends on us as practitioners, our business is made possible by the products and services you offer. AAAOM extends heartfelt appreciation to those advertisers that have traveled the distance in giving your support, and we extend a sincere welcome to those of you that recently joined our family. INDEX TO ADVERTISERS ActiveHerb Technologies, Inc. 510-487-5326 1-888-805-HERB(4372) Lhasa Medical Inc. 800-722-8775 Back Cover AOMA - Austin (800) 824-9987 ext. 209 35 Mayway 800-2-MAYWAY American Acupuncture Council 800-838-0383 36 Oregon College of Oriental Medicine 503-253-3443 ext. 201 36 Blue Poppy 800-487-9296 35 Pacific Symposium www.PacificSymposium.org 34 Five Branches University 408-345-2656 34 Seirin America 800-337-9338 Golden Flower Chinese Herbs 800-729-8509 Kan Herb Company 800-543-5233 28 4 6 Inside Front Cover 33 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 The Career Connection 315-568-3039 2 Inside Back Cover 16 Trudy McAlister Foundation Announces Four Scholarships in 2013 Awards Trudy McAlister Foundation 2013 Scholarship Recipients Carrie Lovemark Katie Ngan Elaina Stover Joanne White The Trudy McAlister Foundation (TMF) is pleased to announce As the Foundation is determined to continue to provide an the recipients the Trudy McAlister Foundation scholarships. increasing number of scholarships, we ask the support of Two scholarships for $3000 each and two scholarships for individuals, vendors, and national organizations to help us $2000 each were awarded. make the opportunity of an Oriental medicine education The recipients of the 2013 TMF Scholarships are: Carrie Lovemark, Five Branches University; Katie Ngan, Southern California University of Health Sciences; Elaina Stover, AOMA Graduate School of Integrative Medicine; Joanne White, New available to deserving, committed students. The Board and Advisors for the Foundation are Gene Bruno, OMD, LAc; William B. Pettis, MS, DOM, LAc; Roni Wilbur, MSOM, LAc; Pamela Lee, PhD; and William Prensky, MD, OMD. England School of Acupuncture. A goal of the foundation is to provide generous assistance to deserving students of Oriental medicine and, at the same time, grow and preserve funds for future scholarships. Each year the Foundation Board announces the scholarships in national publications and requests that the Council of Colleges for Acupuncture and Oriental Medicine notify colleges about these scholarships. Remember, the nonprofit Foundation has 501(c)(3) status and contributions from suppliers, manufacturers, individuals, colleges, vendors and organizations can be made directly to the Trudy McAlister Foundation and via the website. All who contribute are recognized on our website. More information is available at www.trudymcalisterfoundation.org The American Acupuncturist 29 BOOK REVIEW Evaluating the Economics of Complementary and Integrative Medicine by Patricia Herman, ND, PhD Reviewed by Elizabeth Sommers, PhD, MPH, LAc Acupuncturists in the U.S. are faced with economic realities related to Paperback, 100 pages patients’ challenges with out-of$15.95 pocket payment for services, insurers’ Available at Amazon and requirements for documentation, www.SamueliInstitute.org and demands from research funders. The need to upgrade our understanding of economics has never been more salient. The new handbook by Patricia Herman ND, PhD, Evaluating the Economics of Complementary and Integrative Medicine, is a valuable resource as both a text and a reference. Her descriptions and examples effectively demystify health economics and offer valuable insight into understanding how to design or interpret cost-related studies. Herman’s book is replete with relevant examples and illustrations of economic principles and is useful for both students and practitioners. Using a variety of studies of interest to the community of complementary and integrative health proponents, she provides definitions and de-constructs concepts and terminology. Although the book contains references to studies of chiropractic, massage, naturopathic care, Alexander technique, homeopathy, and music therapy, there are substantial references related to a number of aspects of Chinese and Asian medicine, including acupuncture, moxibustion, and Tai Qi. The book begins with an overview of the fundamentals of economic analysis. One of these is the perspective from which an evaluation is done. Perspectives encompass the spectrum of those affected by health costs—individual consumers, health insurers, employers, hospital and health care providers, and society itself. Consideration of costs will include direct medical costs (including costs of any of the following: medication or outpatient visits, hospital stay, lab or diagnostic tests, emergency room visits); direct non-medical costs (intervention-related costs such as transportation, patient’s time, childcare); or indirect costs (usually from a broad societal perspective including changes in work-related productivity or an individual’s ability to contribute to society). All these factors are taken into consideration in determining the type of economic evaluation to conduct. The major four types of complete economic evaluation are cost effectiveness analysis, cost utility analysis, cost benefit analysis, and cost consequence analysis. Costs, in whatever forms we decide to measure them, become the numerator in each of these approaches. The denominators represent a variety of impacts to health, as illustrated in the table on the following page. ISBN: 978-1479390359 2012 30 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 “Sham procedures frequently result in small, non-negligible effects. Thus, by comparing a relatively larger effect (due to true acupuncture) with a smaller effect (related to the sham comparison), study results often fail to achieve significance from a statistical perspective.” The value of Herman’s book lies not only in describing principles of health economics but also in its visionary approach to conceptualizing future research on acupuncture and Asian medicine. By incorporating and appreciating the importance of economic evaluation, researchers can reach beyond the limited paradigm of the randomized clinical trial that relies on sham or placebo comparators. A critical point against sham or placebo-controlled trials is that economic analyses are most appropriately conducted by comparing an intervention to the current standard of care, not to a placebo. Just as this is relevant for all types of health-related studies of biomedical interventions, I expect we’ll be seeing this manifest in acupuncture studies as well. Furthermore, recent studies have indicated that sham or placebo comparators may indeed have physiological effects and thus are not inert.6 Imaging studies using magnetic resonance or other scanning approaches have recorded effects associated with sham procedures. Biomarkers and hemodynamic indicators such as blood pressure also provide evidence of physiological changes, which become evident following sham procedures.7 Sham procedures frequently result in small, non-negligible effects. Thus, by comparing a relatively larger effect (due to true acupuncture) with a smaller effect (related to the sham comparison), study results often fail to achieve significance from a statistical perspective. Although clinicians and patients may observe favorable health-related outcomes, the final results may not show a difference that achieves a large enough difference between true and sham procedures, thus leading to the false conclusion that true acupuncture procedures are no better than comparison or placebo procedures. Herman’s book offers insight into the world of health economics. Like our own science of Asian medicine, health economics offer a holistic, comprehensive and inclusive approach to understanding the ramifications of our medicine. More importantly, for society and the public’s health, economic analyses represent additional Book Review: Evaluating the Economics of Complementary and Integrative Medicine Type of Analysis Health Impact Measured Advantages Limitations Examples Cost effectiveness analysis (CEA) Standardized unit of health outcome (e.g., years of life saved, changes in hemoglobin A1c) Can directly use units of health outcome as determined by effectiveness trials; if health outcome is widely accepted metric for a particular disorder, CEA can use that outcome to directly compare results across a number of therapeutic interventions Does not allow direct cost comparisons over a variety of interventions available for different disorders; although intervention may favorably impact a number of health parameters for a given disorder, CEA could not accommodate multiple outcomes Cost per reduction in breech birth presentations following moxibustion of BL671 Cost utility analysis (CUA) Global health status (broad measures of health) By incorporating a broad measure of health, allows direct comparisons across a number of different therapeutic approaches; integrates measurements related to quality of life Challenge of actually defining and interpreting “utility” Studies of acupuncture for a variety of conditions (osteoarthritis, rhinitis)2,3 “Utility” defined as strength of individual’s health preferences in the context of uncertainty Cost benefit analysis (CBA) All benefits measured in monetary terms Costs can be directly subtracted from benefits to give net monetary benefit of one intervention versus another intervention; allows for comparisons to be conducted across different therapies; can incorporate benefits that are not health-related per se (e.g., patient empowerment) Requires monetary value to be placed on health states Use of naturopathic care for low back pain4 Cost consequence analysis (CCA) Method for reporting results of a comprehensive economic evaluation Based on inclusive list of cost components and associated outcomes for multiple therapies; can include specific health outcomes as well as quality of life measures Full information may not be available for each intervention being considered Comparison of acupuncture, manual therapy, injections, and other pain management techniques for back pain and knee injury5 and innovative frameworks for evaluating and improving care and treatment. I highly recommend Evaluating the Economics of Complementary and Integrative Medicine as a guide and resource for continuing to explore our dynamic field of Asian medicine. 6. Linde K, Niemann K, Meissner K. Are sham acupuncture interventions more effective than (other) placebos? A re-analysis of data from the Cochrane Review on placebo effects. Forshende Komplementarmedizin 2010;17:259-264. References Elizabeth Sommers, PhD, MPH, LAc is director of research and education at Pathways to Wellness in Boston, MA. She is on the faculty at Boston University School of Public Health in Health Policy and Management and co-chairs the American Public Health Association’s group on Complementary and Alternative Health Practices. She has published numerous papers on public health aspects of acupuncture. Areas of interest include acupuncture studies related to health economics, recovery from substance use, and promoting health for people living with HIV/ AIDS. She was guest co-editor for the 2013 public health issue of the European Journal of Integrative Medicine. 1. Van Den Berg I, Kaandrop GC, Bosch JL, Duvekot JJ, Arends LR, Hunink MG. Cost-effectiveness of breech version by acupuncture-type interventions on BL 67, including moxibustion, for women with a breech fetus at 33 weeks gestation: A modeling approach. Complementary Therapies in Medicine 2010 April;18(2):67-77. 2. Reinhold T, Witt CM, Brinkhaus JS, Willich SN. Quality of life and cost-effectiveness of acupuncture treatment in patients with osteoarthritis pain. European Journal of Health Economics 2008;9(3):209-219. 3. Witt CM, Reinhold T, Jena S, Brinkhaus B, Willich SN. Cost effectiveness of acupuncture treatment in women and men with allergic rhinitis: A randomized controlled study in usual care. American Journal of Epidemiology 2009;169(5):562-571. 4. Herman PM, Szczurko O, Cooley K, Mills EJ. Cost- effectiveness of naturopathic care for chronic low back pain. Alternative Therapies in Health and Medicine 2008;14(2):32-39. 7. Choi EM, Jiang F, Longhurst JC. Point specificity in acupuncture; Chinese Medicine 2012,7;4.http://www.cmjournal.org/content/7/1/4. Accessed 3/12/13. 5. Brown APL, Kennedy ADM, Torgerson DJ, Campbell J, Webb JAG, Grant AM. The OMENS Trial: Opportunistic evaluation of musculoskeletal physician care among orthopaedic outpatients unlikely to receive surgery. Health Bulletin 2001;59(3):199-210. The American Acupuncturist 31 Acupuncture Improves Working Memory continued from page 13 One limitation of this study design is that subjects in the control group did not know that they were in the control group, but subjects in the acupuncture group did know that they were in the active group. To reduce any potential effect this difference may create, future research may incorporate a placebo-pill for the control group so that every subject believes they are receiving an active treatment. This research shows only the short-term effects of one acupuncture treatment. Future study should investigate: A) how long these effects last and B) how much more effective a course of treatment may be compared to just one treatment. Future study may also investigate the relative effectiveness of different point combination and manipulation methods. The trends found in gender differences and HA/LA groups approached statistical significance and may reach significance in a larger sample. For this reason, it would also be beneficial to reproduce this exact study using a larger number of subjects. Future study should also examine subjects of different ages as there is no reason to assume that these benefits are limited to individuals aged 18-30. This research presents a new use for acupuncture services. It is helpful not only for those who are functioning sub-optimally, but it can help healthy individuals perform even better. With further study, we might learn that acupuncture may improve performance on the SAT, GRE, MCAT, board exams, and other important tests. Conclusion This study shows that this acupuncture protocol does improve working memory and does reduce anxiety. However, those effects were found to be unrelated. This technique may be helpful for those who suffer with anxiety and those who wish to improve their memory. References 1. Bussell J. The effect of acupuncture on working memory and anxiety. Journal of Acupuncture and Meridian Studies. 2013; Article in Press DOI: 10.1016/j. jams.2012.12.006. 2. Baddeley AD, Hitch G. Working memory. In: Bower GH, ed. The psychology of learning and motivation: Advances in research and theory. Vol 8. New York: Academic Press; 1974:47–89. 3. Baddeley AD. Is working memory still working? Am Psychol. 2001;56(11):851–864. 4. Daneman M, Carpenter PA. Individual differences in working memory and reading. Journal of Verbal Learning and Verbal Behavior. 1980;19(4):450–466. 5. LeFevre JA, DeStefano D, Coleman B, Shanahan T. Mathematical cognition and working memory. in: Campbell JID, ed. The handbook of mathematical cognition. 1st ed. Psychology Press; 2004. 6. Kiewra KA, Benton SL. The relationship between information-processing ability and notetaking. Contemporary Educational Psychology. 1988;13(1):33. 7. MacDonald MC, Just MA, Carpenter PA. Working memory constraints on the processing of syntactic ambiguity. Cogn Psychol. 1992;24(1):56–98. 8. Shute VJ. Who is likely to acquire programming skills? Journal of Educational Computing Research. 1991;7(1):1–24. 9. Ormrod JE, Cochran KF. Relationship of verbal ability and working memory to spelling achievement and learning to spell. Reading Research and Instruction. 1988;28(1):33–43. 10. Engle RW, Carullo JJ, Collins KW. Individual differences in working memory for comprehension and following directions. Journal of Educational Research. 1991;84(5):253–262. 11. Daneman M, Green I. Individual differences in comprehending and producing words in context. Journal of Memory and Language. 1986;25(1):1–18. 32 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 12. Richardson JTE. Working memory and human cognition. Oxford University Press; 1996. 13. Kyllonen PC, L. Stephens D. Cognitive abilities as determinants of success in acquiring logic skill. Learning and Individual Differences. 1990;2(2):129–160. 14. Kyllonen PC, Christal RE. Reasoning ability is (little more than) working-memory capacity?! Intelligence. 1990;14(4):389–433. 15. Ashcraft MH, Krause JA. Working memory, math performance, and math anxiety. Psychon Bull Rev. 2007;14(2):243–248. 16. Darke S. Effects of anxiety on inferential reasoning task performance. J Pers Soc Psychol. 1988;55(3):499–505. 17. Eysenck MW, Derakshan N, Santos R, Calvo MG. Anxiety and cognitive performance: attentional control theory. Emotion. 2007;7(2):336–353. 18. McDonald AS. The prevalence and effects of test anxiety in school children. Educational Psychology. 2001;21:89–101. 19. Gao L, Zhou Y. Observations on the efficacy of mind-calming and brain-refreshing acupuncture and moxibustion for treating 42 anxiety patients. Journal of Acupuncture and Tuina Science. 2006;4:300–302. 20. Eich H, Agelink MW, Lehmann E, Lemmer W, Klieser E. Akupunktur bei leichten bis mittelschweren depressiven episoden und angststörungen - Ergebnisse einer experimentellen untersuchung -. Fortschritte der Neurologie · Psychiatrie. 2000;68(3):137–144. 21. Williams J, Graham C. Acupuncture for older adults with depression-A pilot study to assess acceptability and feasibility. Int J Geriatr Psychiatry. 2006;21(6):599–600. 22. Karst M, Winterhalter M, Münte S, et al. Auricular acupuncture for dental anxiety: A randomized controlled trial. Anesthesia & Analgesia. 2007;104(2):295–300. 23. Ng SKS, Chau AWL, Leung WK. The effect of pre-operative information in relieving anxiety in oral surgery patients. Community Dent Oral Epidemiol. 2004;32(3):227–235. 24. Rosted P, Bundgaard M, Gordon S, Pedersen AML. Acupuncture in the management of anxiety related to dental treatment: a case series. Acupunct Med. 2010;28(1):3–5. 25. Wong T. Use of electrostimulation of acupuncture points in general dental practice. Anesth Prog. 1989;36(4-5):243–244. 26. Wu S, Liang J, Zhu X, Liu X, Miao D. Comparing the treatment effectiveness of body acupuncture and auricular acupuncture in preoperative anxiety treatment. J Res Med Sci. 2011;16(1):39–42. 27. Pilkington K, Kirkwood G, Rampes H, Cummings M, Richardson J. Acupuncture for anxiety and anxiety disorders—a systematic literature review. Acupuncture Med. 2007;25(1-2):1–10. 28. Joesting J. Test-retest reliabilities of state-trait anxiety inventory in an academic setting. Psychological Reports. 1975;37:270–270. 29. Marteau TM, Bekker H. The development of a six-item short-form of the state scale of the Spielberger state-trait anxiety inventory (STAI). Br J Clin Psychol. 1992;31 ( Pt 3):301–306. 30. Unsworth N, Heitz RP, Schrock JC, Engle RW. An automated version of the operation span task. Behav Res Methods. 2005;37(3):498–505. 31. Deadman P, Al-Khafaji M, Baker K. A Manual of Acupuncture. 2nd ed. Journal of Chinese Medicine Publications; 2007. 32. Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. The Lancet. 2010;375(9715):686–695. 33. Bishop SJ. Trait anxiety and impoverished prefrontal control of attention. Nat. Neurosci. 2009;12(1):92–98. 34. Sorg BA, Whitney P. The effect of trait anxiety and situational stress on working memory capacity. Journal of Research in Personality. 1992;26:235–241. 35. Cherkin DC, Sherman KJ, Avins AL, et al. A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain. Arch Intern Med. 2009;169(9):858–866. 36. Enblom A, Lekander M, Hammar M, et al. Getting the grip on nonspecific treatment effects: Emesis in patients randomized to acupuncture or sham compared to patients receiving standard care. PLoS Clinical Trials. 2011;8(3):1. 37. So EWS, Ng EHY, Wong YY et al. A randomized double blind comparison of real and placebo acupuncture in IVF treatment. Hum Reprod. 2009;24(2):341–348. 38. Facco E, Liguori A, Petti F et al. Traditional acupuncture in migraine: A controlled, randomized study. Headache: The Journal of Head & Face Pain. 2008;48(3):398–407. 39. Vas J. Acupuncture as a complementary therapy to the pharmacological treatment of osteoarthritis of the knee: Randomised controlled trial. BMJ. 2004;329(7476):1216–0. 40. Schneider A, Weiland C, Enck P, et al. Neuroendocrinological effects of acupuncture treatment in patients with irritable bowel syndrome. Complementary Therapies in Medicine. 2007;15:255–263. 41. Lundeberg T, Lund I, Sing A, Näslund J. Is placebo acupuncture what it is intended to be? Evid Based Complement Alternat Med. 2009. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/19525330. Accessed September 20, 2011. Disclosure Statement This was a self-funded study that was conducted as part of the author’s PhD dissertation. There were no financial conflicts of interest. Chinese Herbal Products You Can Trust The American Acupuncturist 33 F I N A N C I A L A I D A V A I L A B L E ! Doctor of Acupuncture and Oriental Medicine D E G R E E P RO G R A M ■ Study with recognized TCM experts Dr. Shunfa Jiao, inventor of head acupuncture and FBU faculty member, teaching doctoral class and Stanford MD professors ■ Option of earning your Ph.D. in China Quarterly Admissions ■ Enhance your expertise with the classics taught by clinical specialists ■ Broad core program and multiple specializations Five BraNches UNIVERSITY ■ Explore the latest integrative medicine research ■ Flexible program with monthly 4-day modules Graduate School of Traditional Chinese Medicine ■ Doctoral modules available to LAc’s as CEU courses. [email protected] ■ (408) 345-2656 See schedule at www.fivebranches.edu/news/818 3031 Tisch Way, San Jose, California 95128 w w w. f i ve b r a n c h e s . e d u Oriental Medicine · Acupuncture · Massage Therapy October 24-27, 2013 The Catamaran Resort Hotel & Spa, San Diego, CA Learn From the Best: Matt Callison Magnolia Goh Mark Kastner Misha Cohen Debra Betts Felice Dunas Rick Gold Osi Livni Kiiko Matsumoto Giovanni Maciocia Jake Fratkin Lillian Bridges Bill Helm Keynote Address: Ted Kaptchuck - October 25 Jeffrey Yuen - October 23 Kiiko Matsumoto - October 28 34 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Giovanni Maciocia - October 28-29 Miki Shima - October 28-29 Where leaders transform. REGIONALLY ACCREDITED DOC TOR AL PROGR AM Modular format for professionals Specialty in pain & associated psychosocial phenomena Apply online at aoma.edu/doctoral-program 4701 West Gate Blvd.Austin, TX 78745 800.824.9987 AOMA’s regionally accredited DAOM program affords students the highest level of academic and professional recognition in the field. Prepare to take a leadership role in the national advancement of TCM. A Study on Scientific Writing continued from page 17 Example: Traditionals, Zizyphus Sleep Formula, Suan Zao Ren Tang, distributed by Kan Herb Company, Scotts Valley, CA. Lot 0610-07, was used in this study. The dose given to the subjects was: 2 tablets, 3 times a day for 5 days on an empty stomach (1 hour before/2 hours after eating). Herbs include: Sour jujube seed (dry fried) (Suan Zao Ren (chao)), Sichuan lovage rhizome (Chuan xiong), Poria (Fu ling), Anemarrhena rhizome (Zhi mu), Chinese Licorice root (Gan cao). When preparing to write a scientific paper, refer to these guidelines but before you begin, PLEASE search for more information online. There are so many fantastic resources for people writing scientific papers. Many of these resources are on the websites of major research institutions and universities. Here are a few: How to Write the Methods Section of a Research Paper by Richard H Kallet, MSc, RRT, FAARC http://cancer.dartmouth.edu/documents/pdf/methods_ section.pdf Scientific Writing Booklet http://cbc.arizona.edu/sites/default/files/marc/ Sci-Writing.pdf http://abacus.bates.edu/~ganderso/biology/resources/ writing/HTWsections.html#methodsstructure 36 T h e A m e r i c a n A c u p u n c t u r i s t Summer 2013 Lead the Way Earn your doctorate in Acupuncture and Oriental Medicine Flexible, modular format benefits non-Oregon residents Specializations in women’s health and healthy aging Federal Financial Aid and scholarships available ACAOM-accredited Doctoral Student for a Day Join us at our campus in Portland’s historic Old Town Chinatown: October 19 – GI Disorders November 16 – Liver Disorders *Both with Guohui Liu, MMed (PRC), LAc Contact Anna Lewis for more information: 503-253-3443 x201 ocom.edu