The Principles, Technique, and Complications
Transcription
The Principles, Technique, and Complications
CARDIOPULMONARY BYPASS The P rinciples, Technique, and Com plications Dr. Saswata Deb, MD, BSc Hon Resident, Cardiac Surgery Mazankowski Alberta Heart Institute University of Alberta Objectives 1 History of CPB 2 Physiological Principles of CPB 3 Components and Technique of CPB 4 Complications History of CPB • • Dr.Gibbons, inventor of the Heart & Lung machine – Also known as, cardio-pulmonary bypass machine (CPB) 1930 – mentor Dr.Churchill, did a pulmonary embolectomy on a female patient – Embolus removed, patient died – “It was then that I found myself thinking how we could have Dr. John H. Gibbons Jr. helped her if we only had had some way of taking out the blue venous blood, getting oxygen into it while carbon dioxide escaped, and then putting the blood back into the arterial system. • • ” 1935 – maintained a cat’s circulation on CPB while closing the pulmonary artery 1936 – teamed with IBM president Thomas Watson and a group of engineers History of CPB • 1953 – Cecelia Bavolek – First patient to undergo open heart surgery using CPB to repair an atrial septal defect Dr. Gibbons & Cecelia Bavolek ...More than 40 years of Innovation, Research, and Hard Work..... Melrose Cross Rygg Objectives 1 History of CPB 2 Principle of CPB 3 Components and Technique of CPB 4 Complications Principle of CPB • Deoxygenated blood (Venous Return) taken away from the body to the CPB machine pumped and oxygenated returned back to the body Principles of CPB • TEAM – Surgeon – Anesthetist – Perfusionist • Ultimately the surgeon is directly responsible for patient outcome, but for success, needs strong/open communication between each team member The CPB Team • Roles – Surgeon • Determines the planned operation, target perfusion temperatures, methods of quadriplegia, annulations • Communicates procedural steps – Connecting/disconnecting CPB, perfusion management, surgical exposure – Perfusionist • Setting up and priming the CPB machine, safety checks, monitoring anticoagulation, adding prescribed drugs, maintaining records – Anesthetist • Anesthesia • “Troubleshooter” of complex procedures along with the surgeon Objectives 1 History of CPB 2 Principle of CPB 3 Components and Technique of CPB 4 Complications Components of CPB • • • • • • • • • Venous and arterial cannulas Venous Reservoir Centrifugal pump Oxygenator, heat exchanger , venous reservoir Microfilter bubble trap on the arterial side Suction systems – Aspirate blood cardiotomy reservoir and filter returns to venous reservoir – Field blood washed in a cell saver system returned as pRBCs Partial and occluding clamps to direct and regulate flow Various ports in the system to obtain blood samples, sensors for monitoring pressures, temperatures, O2 sats, blood gases Cardioplegic system, LV Vent The Complete CPB Circuit Venous Drainage and Cannulation • Venous Drainage – Drains into circuit through venous cannula – Enters circuit by gravity or siphonage into venous reservoir 40-70cm below level of heart – Amount of drainage determined by: • CVP, height differential, resistance in cannulas, tubing and connectors, absence of SI PHON air in the system Venous Drainage and Cannulation • Venous Cannulation • 3 basic approaches – Venous cannulas – usually made of flexible plastic – Size determined by patient size, anticipated flow rate, flow characteristics and resistance • Usually 30F in SVC and 34F in IVC or a single 42F – Bicaval, single atrial, cavoatrial (2-stage Cannula) • 2-stage cannulas (Usual choice) cathether in right atrial appendage • Narrowed distal end into IVC while wider proximal portion has side holes designed to rest within RA • More stable and provides better drainage than single cannula A: Bicaval B: 2-stage Cannula Augmented / Assisted Venous Return • Negative pressure can be applied using roller pump, centrifugal pump or regulated vacuum – Augmented negative pressure increases risk of aspirating air cerebral injury & hemolysis • Positive pressure in venous reservoir air can enter venous lines and right heart • Therefore, must carefully analyze and reevaluate lines and monitors Complications of Venous drainage • • • • • • Arrhythmias Atrial or caval tears Bleeding Air embolization Unexpected decanulation Caval tapes may displace CV or PA monitor catheters • Improperly placed pure-string sutures may obstruct cava when tied Arterial Cannulation Arterial Cannulation Aortic Axillary Femoral Ascending Aortic Cannulation • Tip of arterial cannula narrowest part of the perfusion system • Distal ascending aorta is preferred due to ease of placement and fewest complications • Usually 2 sutures (full or partial thickness) through aortic wall placed • 4-5mm full thickness stab wound made • Cannula inserted under a finger with MAP of 6080mmHg – Cannula inserted 1-2cm with some back bleeding, rotated to ensure that it is in lumen, and positioned to direct flow to the mid-transverse aorta • Proper placement confirmed by noting non-pulsatile pressure in aortic line monitor • Once in place, cannula MUST be secured in place Complications of AA Cannulation • • • • Difficult insertion, bleeding, tear in aortic wall, intramural or malposition of cannula tip, air emboli, plaque emboli, aortic dissection Atherosclerosis of the ascending aorta – Dislodgement of plaque/debris from wall manipulation/Xclamping/or sand-blasting effect of the cannula jet = Major cause of Peri-operative Stroke Majority of surgeons use simple palpation but epiaortic scanning is ideal Epiaortic scanning indicated for: – Hx of TIA, CVA, severe PVD, palpable aortic calcification, calcified aortic knob on CXR Complications of AA Canulation • Aortic dissection – 0.01-0.09% of aortic cannulations – Common in aortic root disease – First SSx – discoloration beneath adventia near cannula site, increase in art line pressure, sharp reduction in return to venous reservoir • Emergency Management: – Transfer cannula to a peripheral artery or uninvolved distal aorta – Control BP pharmacologically – Decrease perfusate temperature to < 20 ºC – Circulatory arrest and repair aorta Femoral Cannulation • First alternative to aortic cannulation • Indicated for initiating CPB quickly, cardiac arrest, acute intraop dissection, limited access – Complications: • Retrograde arterial dissection (0.21.3%) – MOST SERIOUS with 50% mortality • Tears, late stenosis, thrombosis, bleeding, lymph fistula, infection in groin, cerebral or coronary atheroembolism Axillary Cannulation • Increasing use • Aortic surgery, circulatory arrest cases • Advantage: – Freedom from atherosclerosis, antegrade flow into arch vessels, protection of arm and hand by collateral flow • Disadvantage: – Risk of brachial plexus injury, axillary artery thrombosis Components of CPB • • • • • • • • • • Venous and arterial cannulas Venous Reservoir Centrifugal pump Oxygenator, heat exchanger , venous reservoir Microfilter bubble trap on the arterial side Suction systems – Aspirate blood cardiotomy reservoir and filter returns to venous reservoir – Field blood washed in a cell saver system returned as pRBCs Partial and occluding clamps to direct and regulate flow Various ports in the system to obtain blood samples, sensors for monitoring pressures, temperatures, O2 sats, blood gases Cardioplegic system LV Vent Venous Reservoir Venous Reservoir • Placed immediately before arterial pump • Reservoir is high capacitance (low pressure) receiving chamber for Venous Return • Facilitates gravity drainage • Can add drugs, fluids, or blood – Can hold 1-3L of blood when patient on full CPB Venous Reservoir Hard-Open Rigid Plastic Canisters •(+) – facilitate measurements •-easier to prime •-larger capacity •Easier mgt of venous air •(-) – higher risk of micro-emboli d/t silicon SoftClosed Venous Return Reservoirs Collapsible Plastic Bags •Eliminate Blood-gas interface •Collapses reduce risk of air emboli Pumps Pumps • Most machines use 2 types of pumps – Roller pump and Centrifugal pump Pumps • Centrifugal pump – Used in the primary circuit – Consist of nested plastic cones, rotated rapidly, propel blood by centrifugal force – Pumps with up to 900 mmHg forward pressure and 400mmHg of backward pressure • Forward pressure determined by speed of rotation and afterload of the arterial line – Can pump small amounts of air but become deprimed if > than 50mL of air enters blood chamber – Produce pulseless blood flow Pumps • Roller Pumps – Used for central pump, sucker systems and for delivering cardioplegic solutions – Length of polyvinyl silicone/latex tubing compressed by 2 rollers 180 degrees apart – Forward flow generated by roller compression – Flow rate dependent on tubing diameter, rate of rotation, length of compression raceway – Produces a sine wave pulse blood flow at 5mmHg • No evidence to produce pulsatile perfusion during short/long-term CPB Pump Comparison Description Advantages Roller pump Centrifugal pump Nearly occlusive Nonocclusive Afterload independent Afterload sensitive Ease of use Portable, position insensitive Low cost Safe positive and negative pressure No potential for backflow Adapts to venous return Shallow sine-wave pulse Superior for right or left heart bypass Preferred for long-term bypass Protects against massive air embolism Disadvantages Excessive positive and negative pressure Large priming volume Spallation Requires flowmeter Tubing rupture Potential passive backward flow Potential for massive air embolism Higher cost Necessary occlusion adjustments Requires close supervision Pump Complications • • • • Loss of electricity Loss of ability to control pump speed Loss of flow meter or RPM indicator Rupture of tubing in the roller pump raceway • Means to manually provide pumping in case of electrical failure should always be available Heat Exchangers Heat Exchangers • Control body temperature • Hypothermia often preferred – Gasses more soluble in cold than warm blood • Rapid rewarming may cause bubble emboli • Heater is also placed upstream of oxygenator to prevent bubble emboli • Temperature difference between body and perfusate kept <10 • Temp kept < 40ºC to prevent denaturation of proteins • Cardioplegia requires separate heat exchanger • Simplest system is to use bags of precooled quadriplegia solution and is circulated through a dedicated heat exchanger/ice baths Oxygenator Oxygenator • Membrane Oxygenators – Imitates natural lung by providing a thin membrane of either microporous polypropylene or silicone rubber between the gas and blood phases – Plasma filled pores prevent gas from entering blood but allows exchange of Oxygen and CO2 – O2 = poor diffusate in plasma • Blood is spread as thin film over large area with high differential gas pressures between compartments • Areas of turbulence enhance diffusion of oxygen within blood Oxygenator Oxygenator • Can produce upto 470mL of O2 and remove 350mL of CO2 / minute at 1-7L of flow • Other tools in the oxygenator include: – Flow regulators, flow meters, gas blender, oxygen analyzer, gas filter, moisture trap • Malfunctioning of oxygenators occurs in 0.02-0.26% of cases – Most common reason=development of abnormal resistant of blood path in the oxygenator • Heparin coating can help to reduce this – Others include leaks, loss of gas supply, rupture of connections, failure of the blender, and failure of gas exchange – Monitoring of blood gasses is very important to ensure adequate removal of CO2 and oxygenation Heparin Coated Circuits • Can be attached to blood surfaces of all components of the CPB through ionic and covalent bonds • Literature for need is controversial – No credible evidence that heparin-coated perfusion circuits reduce need for systemic heparin, or reduce bleeding or thrombotic problems associated with CPB Cardiotomy Reservoir / Field Suction • Blood aspirated from surgical wound maybe directed to cardiotomy reservoir – Gets defoamed, filtered and added to perfusate • Macro and microfilters are crucial – Negative pressure for suction generated by roller pump – Suction = major sources of hemolysis, emboli, platelet injury, thrombin generation, fibrinolysis – Current reservoirs manufactured to reduce this • Alternate option is cell saver – Field aspirate blood is diluted with saline and saline removed to return only pRBC to perfusate Venting the Heart • RV distention rarely a problem during cardiac arrest • LV distention is a problem – Insidious – Multiple sources of blood • Escaping blood from the atrial or venous cannulas • Blood from coronary sinus and the thebesian veins pass into Pulmonary circulation • Bronchial arterial and venous blood • Blood from Aortic Valve regurgitation • Unknown sources (PFO, PDA) Left Heart Venting • Commonly, multihole, soft-tip catheter (8-10F) inserted into RPSV and LA and into LV • Vent connected to cardiotomy reservoir • Most common complication = Residual air when heart restarted and begins to fill – De-airing maneuvers and TEE important to ensure removal – Aspirate ascending aorta via small metal or plastic cannula Cardioplegia System Cardioplegia System • Solution contains 8-20 MeQ/L of K+, Mg++, and other components • Given Anterograde and/or Retrograde • Temp varies (4-37ºC) – Normothermic continuous – Cold intermittent • Delivered through separate perfusion system that includes a reservoir, heat exchanger, roller pump and bubble trap Filter and Bubble Traps • Can generate gaseous, biologic and non-biologic microemboli – O2, N, thrombus, broken cells, atherosclerotic debris, muscle debris, materials of the circuit • Strategies of prevention – – – – Reduce PCO2 cerebral vasoconstriction Hypothermia Placing cannulas downstream of cerebral vessels Microfilters • Depth and screen filters – Depth – packed fibers or porous forms and removes debris by absorption and impaction – Screen filters – made of woven polyester or nylon thread, defined pore size and filter by interception Perfusion Monitors and Safety Devices Device or procedure Low venous blood level alarm With pump cut-off Usage (%)* 60–100 34–80 High arterial line pressure alarm With pump cut-off 84–94 35–75 Macrobubble detector With pump cut-off 42–88 62–63 Arterial line filter 44–99 Pre-bypass recirculation/filtration 75–81 Oxygen supply filter 81–95 In-line venous oxygen saturation 75–76 Batteries in heart-lung machine 29–85 Back-up arterial pump head 80 Back-up heater-cooler 97 Back-up oxygen supply 88–91 Emergency lighting 62–91 Pre-bypass activated clotting time 74–99 The CPB Team • Roles – Surgeon • Determines the planned operation, target perfusion temperatures, methods of quadriplegia, annulations • Communicates procedural steps – Connecting/disconnecting CPB, perfusion management, surgical exposure – Per fusionist • Setting up and priming the CPB machine, safety checks, monitoring anticoagulation, adding prescribed drugs, maintaining records – Anesthetist • Anesthesia • “Troubleshooter” of complex procedures along with the surgeon The Set-UP • • • • Per fusionist responsible for setting up Takes 10-15 minutes Can be kept on stand-by for upto 7days Takes 15min to prime with fluid, once primed, must be used within 8 hours Priming • Adult circuits require 1.5-2L of balanced electrolyte solution – RL, Normosol-A, or Plasma-Lyte • Volume ~40% of patient’s blood volume – ↓ HCT by 1/3 of pre-op value • Sometimes banked blood added to raise HCT • No consensus on optimal HCT • Usually 20-25% – Dilution may also ↓ O2 carrying capacity and ↓ MvO2 to <60% • If this occurs, need to transfuse or increase pump flow • Sometimes, 12.5-50g of mannitol added to stimulate diuresis minimize post-op renal dysfunction • No evidence to support colloids in the priming volume • Addition of Glucose/Lactate avoided because shown to increase neurologic deficits Anticoagulation • 300 – 400 Units/Kg IV heparin given before arterial and venous cannulation • Porcine vs bovine – Bovine more antigenic – ↑ antiplatelet IgG antibodies • Measure ACT 3 minutes after dose – ACT >400 to begin – If ACT not increasing • May increase heparin dose to 500U/kg • May need FFP (antithrombin) • ACT measured every 30min • Usually 1/3rd of initial heparin dose given every hour to maintain target ACT Reversal • Protamine (1mg/100U of heparin) given • Heparin-protamine complex activates complement hypotension – May need to add Calcium (2mg/1mg protamine) • After 1/3rd of protamine dose administered, blood must not be returned to the cardiotomy reservoir from the surgical field • Neutralization of heparin must be confirmed by an ACT Going on Bypass • Started on surgeon’s request with concurrence of the anaesthesiologist and perfusionist • As VR enters machine, perfusionists progressively increases arterial flow while watching BP and all reservoir volumes • 6 observations are critical: – – – – – – Is venous drainage adequate for desired flow? Is pressure in arterial line acceptable? Is arterial blood adequately oxygenated? Is systemic arterial pressure acceptable? Is systemic venous pressure acceptable? Is the heart adequately decompressed? • Once on full bypass for at least 2 min, lung ventilation discontinued, perfusion cooling may begin, aorta may be clamped for cardiac arrest Key determinants of Safe Perfusion • Blood flow rate – Basic CO determined by O2 consumption (250ml/min) – Generally accepted flow rate with HCT 25%, deeply anaesthetized, muscle-relaxed patient = 2.4L/min/m.sq – For every ↓ 10ºC = ↓ 0.5 of O2 consumption – Also ↓flow = ↓O2 consumption Oxygen Consumption Nomogram Kirklin and Barrett-Boyes suggest that flows be reduced only to levels that permit at least 85% of maximal O2 consumption. Key determinants of Safe Perfusion • Arterial Pressure – Systemic BP = flow rate x viscosity (HCT) x vascular tone – At 24% HCT, MAP between 55-60, adequate to maintain autoregulation • In older patients with vascular disease, MAP generally maintained between 70-80 – Higher MAPs undesirable as it increases blood in the operative field d/t to collateral blood flow to heart and lungs – Hypotension – causes are low pump flow, aortic dissection, vasodilation • Phenylephrine, vasopressin – Hypertension – nitroprusside (arterial dilator), nitroglycerine (venodilator and pulmonary vessel) Key determinants of Safe Perfusion • Hematocrit – Ideal level still under debate – Low HCT = reduced viscosity, hemolysis, and O2 carrying capacity and autologous blood transfusion – Viscosity remains stable when % HCT and Temp are equal – General acceptable %HCT is 20-25% Key determinants of Safe Perfusion • Temperature – Another unsettled parameter – Hypothermic temp (25-30ºC) • Adv=protects brain, permit perfusion at low flows and HCTs, support hypothermic quadriplegia • Disadv=enzyme and organ dysfuntion, aggravates bleeding, increases SVR, delays cardiac recovery, higher embolic risk – Since embolic risk of cerebral injury > perfusion risk, tepid temperature (33-35ºC) recommended Key determinants of Safe Perfusion • pH/Pco2 • 2 strategies – pH-stat – maintains pH at 7.40 at all temperatures • Requires addition of CO2 while cooling • Cerebral blood flow is higher, and uncoupled to cerebral oxygen demand • Recommended for pediatric surgery – Alpha-stat – pH allowed to increase during cooling • Blood becomes alkalotic • Cerebral blood flow is lower, autoregulated, and coupled to cerebral oxygen demand Key determinants of Safe Perfusion • PaO2 – >150mmHg to assure complete arterial saturation • Glucose – Some concerns that hyperglycemia related to neurologic injury • Still under research Patient Monitors • • • • Radial/brachial/femoral arterial catheter CVP via jugular venous catheter Routine use of Swan-Ganz PA cath controversial TEE – important tool for cathether and vent insertion, aortic atherosclerosis, thrombi and air assessment, contractility, valve function, diagnosis of dissection • Urine output • Temperature – Nasopharyngeal or tympanic membrane temp used more commonly – arterial line temp correlates best with jugular venous bulb temp (best surrogate for brain temp) Coming off Bypass • Prior to stopping – Patient re-warmed to 34-36ºC – heart defibrillated, lungs re-expanded and ventillated – Cardiac rhythm, HCT, blood gases, acidbase status, plasma electrolytes reviewed – TEE for air detection – Caval catheters are adjusted to ensure no obstruction to venous return to heart Coming Off Bypass • Weaning off bypass – Venous line gradually occluded – As flow rate approaches zero, volume is added/removed to keep arterial and venous pressures within physiologic range – Cardiac filling, contractility, and repairs are assessed while weaning – Once sats near 100%, ETCO2 >25mmHg, and MvO2 >65% = satisfactory circulation – If all satisfied, can give protamine, remove annulations. Objectives 1 History of CPB 2 Principle of CPB 3 Components and Technique of CPB 4 Complications Complications Coagulation Inflammatory Systemic Dysfunction Pathophysiological Response • Triggers – Passage of blood through non-endothelial circuitry – Temperature change, acid-base balance, hemodilution, non-pulsatile flow, drugs, circulatory pump and bypass mechanics Activation of Blood Constituents • Plasma protein systems (5) – – – – – Contact Intrinsic System Extrinsic System Complement Cascade Fibrinolytic Cascade • Cellular systems (5) – – – – – Platelets Neutrophils Monocytes Lymphocytes Endothelial cells Plasma Proteins • Blood + non-endothelialized surface adsorption of plasma proteins onto the surface • Protein layer created • LAYER VARIES WITH THE MATERIAL AND DURATION OF EXPOSURE • Dynamic between circulating and adsorbed proteins is established • Heparin coated circuits change the reactivity of these proteins but DOES NOT reduce thrombogenecity Plasma Protein System • Contact System – procoagulant + pro-inflammatory • Intrinsic System procoagulant • Extrinsic System procoagulant • Complement System pro-inflammatory • Thrombin production – pro-coagulant + anti-coagulant – Activated by non-endothelial surfaces – F12, 11, prekalikrein and kinogen – Activates the intrinsic pathway, complement pathway, and neutrophils – Activated by the contact system – Activates F10 (300,000x more than Extrinsic system) – Wound surface tissue damage Tissue Factor Extrinsic system activation – F12 C1 of the classic complement pathway – CPB alternative complement pathway (C3 based) – Classic + Alternative pathways increase capillary permeability, alter vasomotor tone, impair cardiac function, mast cell and platelet activation – Stimulates endothelial cells to produce TPA progressive fibrinolysis Cellular System • Platelet activation • Neutrophils • Monocytes • Lymphocytes (B-cells, natural killer cells, T-cells) • Endothelial cells – Activated by G2b/3a receptor complex • Stimulants include heparin, thrombin, complement, plasmin, PAF, adrenaline • Result in decrease platelets major cause of post-op bleeding – Activated by complement, kallikrein, F12, interlukins • Increase neutrophils in lungs increase capillary permeability interstitial edema – Activated by contact with circuit, complement, and endotoxins • Help to produce TF and multiple cytokines – Reduced by CPB – Increase risk of infection post-op – Increase in TPA production in response to thrombin activates fibrinolytic pathway Optimal Balance Systemic Dysfunction • Major causes = micro-emboli + hypoperfusion • Hemostatic – Complications related to Platelet activation, heparin, protamine – Bleeding time after full CPB reversal does not return to normal for 4-12 after bypass • Fluid balance – Massive shift into interstitum • Increase in inflammatory process increase in capillary permeability, increase in systemic venous pressure, volume loading • Endocrine – Stressors, hypothermia, CPB, non-pulasite flow increased cortisol, adrenaline and noradrenaline, glucose for at least 24hrs after surgery – Decrease in circulating T3 Systemic Dysfunction • Cardiac – Difficult to decipher post-op cardiac dysfunction and injury due to CPB – Subject to emboli, cytotoxins – Myocardial “stunning”, reperfusion injury • Lung – Pulmonary edema (complement activation and neutrophil sequestration) – CPB reduces effect of natural surfactant reduces pulmonary function – CPB increases shunts, reduces compliance and functional residual volume – ARDS Systemic Dysfunction • Kidney – Hemodilution, microemboli, catecholamines, diuretics, hypothermia, aprotinin all impair renal function • GI – Peptic ulcers (from surgical stress) – Pancreatitis and mild jaundice – Gastroenteritis (from increase inflammatory response) Systemic Dysfunction • Brain – Most sensitive organ exposed to injury by CPB – Difficult assessment – but hard outcomes are stroke, delirium, coma – Risk increases with age (>60) • Proximal aortic atherosclerosis and PHx of neurologic disease ↑ ↑ ↑ ↑ risk – Mechanism – microemboli (air, debris, fat) or hypoperfusion – Protection strategies • Mild hypothermia, HCT>25%, cerebral perfusion, offpump Neuro-dysfunction follow CVSx Percentages of patients with deficits on two or more tests. (n = 374). 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