Knowledge Based BioEconomy KBBE

Berlin, 10.11.2010
Knowledge Based BioEconomy KBBE
Wachstumsmotor Weiße Biotechnologie
Biotechnology Research
ha
no
A n dBIino ft oe rcm
t i loong yN eRtewsoerakr cAhG
And Information Network AG
Dr. Holger Zinke, Gründer und Vorstand BRAIN AG
En Route to the Knowledge Based Bio-Economy (KBBE)
(…) Biotechnology will be an important pillar of Europe´s economy by 2030,
indespensable to sustainable economic growth, employment, energy supply and to
maintaining the standard of living. It will be increasingly used in labour-intensive
sectors, e.g. industrial processing, pharmaceuticals, agriculture an food. By 2030,
the products of white biotechnology and bio-energy will have an estimated onethird share, worth 300bln€, of industrial production.
“En Route to the Knowledge-Based BioEconomy”
Cologne Paper, May 30, 2007
2
© Copyright 2010 BRAIN AG, All Rights Reserved
Knowledge Based BioEconomy and the Colour-Code of Biotechnology
red
biotechnology
white
biotechnology
Feed/Food/Agro
industry
Specialty
Chemicals
[ 79 bln. € (13.5%) ]
Fine
Chemicals/API
green
biotechnology
[ 23 bln. € (4%)]
White Biotechnology:
Application of nature´s
toolbox
in industrial production
[Fine Chemicals: 56 bln. € (9.5%)
Pharmaceuticals: 146 bln. € (24.9%)]
[EuropaBio, Bruxelles 2003]
Bulk
Chemicals
[54 bln. € (9.3%)]
[…] = EUMarket total Vol. 537bln€, CEFIC data 2007
Home and
personal-care
[ 61 bln. € (10.4%)]
BioFuels/BioEnergy
[Polymers & Petrochemicals 166 bln. € (28.4%)]
Polymers
3
© Copyright 2010 BRAIN AG, All Rights Reserved
Strongly growing industrial “white” biotechnology markets
Share of industrial “white” biotechnology within chemicals industry
2010
2005
7%
Bio-dependent sales 2005 vs. 2010 (bln €)
CAGR 2005-2010
Biof uels
28
72
20.8%
10%
Plant extracts
20
Pharmaceutical
ingredients
25
10
4.6%
20
14.9%
90%
93%
Bulk/polymers
Industrial "w hite" biotechnology
19
31
10.3%
8 11
6.6%
Total chemical industry
Food/f eed
ingredients
Growth rates
CAGR: 4.0%
Oleochemicals
8 9
2.4%
Enzymes
23
8.4%
Others
12
14.9%
€ billion
CAGR: 12.6%
1,400
95
2005
1,700
Total Bio
172
2010
Industrial "w hite" biotechnology
2005
95
172
12.6%
2010
Total chemical industry
2005
2005-2010 grow th
Industrial “white” biotechnology is rapidly growing and estimated to account for 10% of chemicals sales in 2010
4
© Copyright 2010 BRAIN AG, All Rights Reserved
Source: McKinsey: Industrial Biotechnology – a perspective on the industry
Dimensions of sustainability as drivers of BioEconomy/White Biotechnology
Sustainability triangle and Drivers
Underlying fundamental
trends
Innovation need
Margin pressure
Increasing energy prices
Increasing demands in emerging markets
Raw material pricing
Globalization
Economical drivers
Sustainability
triangle
Societal drivers
Ecological drivers
Underlying fundamental
trends
Growing population
Aging population
New markets
Demand for healthy
products
Underlying fundamental
trends
Regulation issues
Raw material access
Disposal of waste
Green chemistry
Industrial “white” biotechnology addresses all three dimensions of sustainability
5
© Copyright 2008 BRAIN AG, All Rights Reserved
Source: Brundtland report 1987, BRAIN
The Biological Knowledge Explosion drives Innovation in BioEconomy
Full Genomes
GenBank
Repository
DNA Sequence Output
Kilo BasePairs
Per Day
Sequence Information
BasePairs / Entries
GenBank
Repository
6
© Copyright 2008 BRAIN AG, All Rights Reserved
European Chemical Industry faces Challenges
Production
Employment
R&D spending
7
© Copyright 2010 BRAIN AG, All Rights Reserved
Source: McKinsey 2008: Industrial Biotechnology – a perspective on the industry
Industrial Transformation: Enzymes are the Active Ingredients of Detergents
Detergents become more and more “biological” HighTech Products. Why?
Courtesy Henkel KGaA, Düsseldorf
8
© Copyright 2008 BRAIN AG, All Rights Reserved
Industrial Transformation: Developping an „ideal“ Production organism
Use of State-of-the-Art Technology is crucial for economic success
(yield, lys concentration, volumetric productivity)
1,0
0,9
Lysine Fermentation Technology
Performance in Industrial Production
0,8
0,7
0,6
0,5
Company D
Genomic Design
Metabolic engineering,
functional genomics
and systems biology
Company A
Pioneer and broad R&D basis with
focus on technology leadership
0,4
0,3
0,1
Company B
Constrained to classic strain optimization by
random mutation and selection
0,0
1960
1970
0,2
1980
1990
Company C
Applying metabolic
engineering
2000
2010
2020
Courtesy Dr. Ralf Kelle, EvonikDegussa R&D Health & Nutrition / Feed Additives
© Copyright 2008 BRAIN AG, All Rights Reserved
Source: Lorenz & Eck (2005) Nature Microbiology Rev 3: 510-516
9
The Network Enterprise Concept: Alliance organizations are complex but efficient
Vertical/Horizontal Organization
Prof. Dr. Manuel Castells, University of California, Berkeley
Department of City and Regional Planning
Berkeley's Center for Western European Studies
Network Organization
The Information Age: Economy, Society, and Culture,
The Rise of the Network Society, The Information Age: Economy, Society and Culture, Vol. I. M. Castells (1996).
Cambridge, MA; Oxford, UK: Blackwell, 556 pp., ISBN 1-55786-617-1
The Power of Identity, The Information Age: Economy, Society and Culture, Vol. II. M. Castells (1997).
Cambridge, MA; Oxford, UK: Blackwell, 461 pp., ISBN 1-55786-874-3
The End of the Millennium, The Information Age: Economy, Society and Culture, Vol. III. M. Castells (1997).
Cambridge, MA; Oxford, UK: Blackwell, 418 pp., ISBN 1-55786-872-7
10
© Copyright 2010 BRAIN AG, All Rights Reserved
Chemical industry reacts on KBBE challenge
Companies
Year
Event
2002
Sale of petrochemistry unit
2002
Acquisition of Roche Vitamins
2005
€ 150 million for Industrial “white” biotechnology R&D
2005
€ 50 million for industrial “white” biotechnology S2B
+
2006
Collaboration on biopolymers (glycolic acid)
+
2007
€ 250 million: Joint effort of industry + BMBF
2007
Emerging business area: Industrial “white” biotechnology
+
2008
Cooperation on bioethanol
+
2008
Cooperation on bioethanol
+
2008
50/50 JV on cellulosic ethanol
11
© Copyright 2010 BRAIN AG, All Rights Reserved
Source: Press releases
Industrial Joint Ventures and Strategic Technology Alliances established
Technology Partner
JV/Joint
R&D
Size
Year
Industrial Partner
Burcon
Nutrascience
NA
ADM
2003
Metabolic Explorer
Biochemicals
NA
Roquette
2006
Metabolix
Bioplastics
> $ 100 mill.
ADM
2006
Codexis
Bioethanol
> $ 30 mill. *
Shell
2007
AB Enzymes
Bioethanol
NA
DuPont, BP
2007
Genencor
Bioplastics
NA
DuPont
2008
Verenium
Bioethanol
> $ 90 mill.
BP
2008
Synthetic Genomics
Bioethanol
> $ 600 mill.
Exxon
2009
Algenol
Bioethanol
> $ 30 mill.
Dow
2009
Senomyx
Sweet. Enh.
> $ 35 mill.
Firmenich
2009
(…..)
To be continued ….
12
© Copyright 2010 BRAIN AG, All Rights Reserved
German BioEconomy Landscape & White Biotechnology R&D Activities
Academic Cooperation Network
German Cooperation Partners
J acobs University Br emen
D ep artment of Biolo gical Engineeri ng
Prof. Dr. Ulrich Schwaneb erg
C omputation al Chemistry and Bi ochemistry
Dr. D anilo Roccatano
MPI für Marine Mikr obiologie Br emen
Microbial Genomics
Prof. Dr. Fran k Ol iver Glöckner
Technische Univer sität Brauns chweig
Insti tut für Technische Chemie
Prof. Dr. Klaus Buchholz / PD Dr. Jürg en Sei bel
Univ ersitätsklinikum Düsseldorf
H au tkli nik
PD Dr. med. Hel ger Stege
Heinrich-Heine-Univ ersität Düsseldorf
Insti tut für Molekul are Enzymtechn ologie (IMET)
Prof. Dr. Karl-Erich J äger
Technische Univer sität Darmstadt
Org anische Chemie und Biochemie
Prof. Dr. Harald Kolmar
Microbiol ogy & Gen eti cs
PD Dr. Arnu lf Kletzin
Johann Gutenberg Univer sität Mainz
Insti tut für Mikrobiol ogie und Wei nforschun g
Prof. Dr. Helmut Kön ig
Hoc hschule Mannheim
Faku ltät für Biotechnol ogie
Profs. W. Storhas/M. Mack /M. Hafn er
Univ ersitäts-Hautklinik Tübingen
Zentrum für Hauttumoren
Prof. Dr. med. Cl aus Garbe
Univer sität Rostock
Institut für Chemi e
Prof. Dr. U do Krag l
Ernst-Moritz-Arndt-Univer sity Gr eifswald
Dep t. of Biotechnolog y & Enzyme C atal ysi s
Prof. Dr. Uwe Bornscheuer
Dep artment o f Applie d Microbi ology
Prof. Dr. Fried er Schau er
Universität H ambur g
Al lgemeine Mikrobiol ogie un d Biotechn ologie
Prof. Dr. Wolfgang Streit
Georg-August-Universität Göttinge n
Institut für Org. und Biomolekul are C hemie
PD Dr. Stefan ie Grond
Institut für Forstbo tani k
Pr of. Dr. Ursul a Kües
Leibniz Inst. forN atural Product R esear ch
and Infection Biology e.V.
Hans-Knöll-Institute (HKI), Jena
Dr. Marti n R oth
Johann-Wolfgang-Goethe-Univer s. Frankfurt
Insti tut für mo lekulare Biowissenschaften
Prof. Dr. Beatri x Süß
60 industrial cooperations based on BRAIN technology
Julius-Maximilians-Universität Würzburg
Ze ntrum für Infektionsforsch ung
PD Dr. Ute Hentschel
Univer sität Hohenheim
Inst. für Lebensmittel wissenschaft und Biotech.
Prof. Dr. J örg Hinrichs / Prof. Dr. Lutz Fischer
Cooperation
examples
Univ ersität Stuttgart
Insti tu te of Technical Biochemistry
Prof. Dr. Rolf D. Schmi d/ Prof. Dr. Jürgen Pl eiss
Specialties / Personal-care
Pharmaceutical ingredients
Food / Feed ingredients
EvoSolution®: for novel BioActives
and novel Enzymes
Datei unte r: CompanyData/accounting and finances/Project APPLE/Name_Ver sion... 18
BioArchives & Biodiversity
B RAIN´s pr oprietary Screening R esour ces & Techno log ies
BRAINzym e®
Ev oSolution
®
®
BioBased Chemicals / Polymers
Enzymes
LIL®
ABEL ®
Oleochemicals
17
© Copyrig ht 2010 BRAIN AG, All Rights Reserved
13
© Copyright 2010 BRAIN AG, All Rights Reserved
Vielen Dank!
Berlin, 10.11.2010
Knowledge Based BioEconomy KBBE
Wachstumsmotor Weiße Biotechnologie
Dr. Holger Zinke, Gründer und Vorstand BRAIN AG
Biotechnology Research
ha
no
A n dBIino ft oe rcm
t i loong yN eRtewsoerakr cAhG
And Information Network AG
[email protected] +49-6251-9331-0