2010 BTCCRC Research Report - School of Medicine

BTCCRC
2010 RESEARCH REPORT
Mission and Aims
1
Report - Chair
2
Executive Profiles
3
Advisory Board Members
4
Fulbright Senior Specialist Visit
5
Research Interests
6
Research Themes
10
Researcher Showcase
19
Research Funding
21
Student Supervision
22
Research Students
23
Visiting Researchers
28
Publications
29
Teaching Activities 33
Achievements and Awards
Conferences
34
35
Workshops/Courses 38
Professional Activities
39
Trauma Research Group 41
New Staff 43
Collaborators 44
Enquiries 47
Burns Trauma & Critical Care
Research Centre
Level 3 Ned Hanlon Building and Level 7 Block 6
Royal Brisbane & Women’s Hospital
Herston QLD 4029
Proudly supported by
OUR MISSION
AND
OUR AIMS
Overview
The Burns Trauma & Critical Care
Research Centre was established in 2002 in
response to the Bali bombings. The
devastation and tragedy of this event
focused national and international attention
on burns victims and emphasized that there
was a critical need to improve the treatment
and outcomes of burnt and critically ill
patients. The outstanding response from the
critical care, burns, emergency medicine
and anaesthetics teams of the Royal
Brisbane & Women‘s Hospital (RBWH) and
The University of Queensland (UQ)
highlighted the skill and expertise we
possess in this area.
Our Mission
The Burns Trauma & Critical Care Research
Centre was established to further advance and
improve the level of treatment and care given to
burns and critically ill patients through worldclass research-based clinical practice.
It began as a collaborative venture between the
RBWH Burns and Intensive Care Units, the
University of Queensland and has incorporated
the Departments of Anaesthesia and Emergency
Medicine.
The research within the centre is divided up
into five core disciplines, each with their
own research agenda.

Burns — the overall management
and outcomes of burns patients.
Our Aims
The main aims of our research centre are to:

Improve both the survival and outcome of
patients by conducting high quality research in
the area of Burns, Trauma, Critical Care,
Emergency Medicine and Anaesthesia in
general.

Antibiotic dosing, distribution and
pharmacokinetics in burns and nonburns critically ill patients.

Provide a research-driven evidence base that
informs clinical practice and policy in Burns,
Trauma, Critical Care, Emergency Medicine
and Anaesthesia.
Management and outcomes of nonburns critically ill patients.

Anaesthesia—evaluating new
procedures for anaesthetising
critically ill patients.

Establish local, national and international
collaboration in these areas thus increasing
research opportunities.


Enhance the research training and knowledge
base of postgraduate students and staff in the
above clinical areas.
Emergency Medicine—improving
outcomes and evaluating new
processes for treating patients in the
Emergency Department.

1
REPORT FROM THE CHAIR
The year 2010 has been one of continuing success and expansion for the
BTCCRC. We are now a thriving centre with clinicians and scientists from critical care, burns, trauma, emergency and anaesthetics involved in cutting edge
research.
We have enrolled a number of new postgraduate students in 2010 including
Bernadette Bissett, Geetha Kayambu and Syamhanim Adnan and are also a
popular centre for clinical doctorate, coursework masters and Honours students.
Our staff continued to be in high demand nationally and internationally and Professor Jeffrey Lipman, Professor Anthony Brown, Dr Jeremy Cohen, Dr Andrew
Udy, Dr Jason Roberts, Dr Andrew Holley and Dr Jennifer Paratz presented
either workshops or invited papers at international venues.
We were fortunate to win a Fulbright Senior Specialist award this year and Professor Andy Shorr from the University of Washington spent a number of weeks with us at the BTCCRC. Professor Shorr is an intensivist, a thoracic physician and a specialist in outcomes research. All who attended from his stimulating lectures, workshops
and individual consultation would agree the visit was extremely worthwhile.
We also had notable success with NHMRC funding with Professor Jeffrey Lipman, Dr Jeremy Cohen and Dr
John Gowardman all receiving grants. Assoc. Prof Michael Steyn was successful in securing an ARC Linkage
grant, whilst Dr Jason Roberts was part of a $5,000,000 Wellcome trust grant. A number of clinical staff received significant RBWH Foundation grants including Arianne Churchill, Judith Bellapart, Marc McGuire, Martin
Wullschleger, Michael Muller, Jeff Lipman, Jason Roberts, Jeremy Cohen, Joel Dulhunty, Louise Cullen and
Merrilyn Banks. Emergency staff Julian Williams and Louise Cullen continued their success with further Queensland Emergency medicine Research Foundation (QEMRF) grants.
As further recognition of our staff excellence, Dr Jason Roberts received the prestigious Deans Award for his
PhD studies. Assoc. Prof Michael Muller received recognition for his burns prevention study with prizes for the
best paper received at both the Trauma symposium and the RBWH research week. Dr Anthony Holley received
the Australian Defence Force‘s Matthew Davey Award which facilitated a visit to Amsterdam for work on blood
products in the military. Dr Keith Greenland submitted his MD on airway management and will undoubtedly receive positive news in 2011.
We also thank the Maggiolo family for their generous support throughout the year. Their support has enabled
the continued clinical and academic research education of our staff.
Thank you to everyone for the continuing hard work and dedication and we look forward to a successful year in
2011.
Jennifer Paratz
2
Professor Jeffrey Lipman
MBBCh DA (SA) FFA (SA) FFA (CritCare) (SA) FJFICM MD
Director of BTCCRC, Director of Department of Intensive Care Medicine (DICM), RBWH
Professor, Anaesthesiology & Critical Care University of Queensland
Jeff is a co-director of the BTCCRC, Director of Department of Intensive Care (DICM), RBWH and
Professor of Anaesthesiology & Critical Care, University of Queensland and Honorary Professor,
Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong. He has
qualifications in anaesthesia and intensive care and has set up and run a number of Intensive
Care and Trauma Units in South Africa before coming to Australia in 1997. He is the author of over 240 peer reviewed
publications, 25 book chapters, has been invited to present at many national and international conferences and is a
reviewer for a number of high quality international journals and granting committees, including the NHMRC. He is
involved with a large number of committees, including ANZICS clinical trials group. Jeff has been instrumental in
developing the anaesthesiology & critical care component of the new graduate medical program for Queensland and
continues to lecture to medical and postgraduate students. He is site Principal Investigator for numerous multinational
trials. Research interests include all aspects of management in intensive care, resuscitation of burns and
pharmacokinetics of antibiotic dosage. His research into antibiotic usage in acute situations has received international
recognition. Jeff is involved in most research projects, oversees the direction of the research centre, mentors staff and
supervises postgraduate students attached to the research unit.
Dr Michael Rudd
MBBS FACS OAM PhD
Co-Director BTCCRC, Director of Burns Unit, RBWH
Michael is the other Co-Director of the BTCCRC and the current director of the Adult Burns Unit
at RBWH. He has fellowships in Burns and General Surgery. Michael has completed a PhD in
transplantation immunobiology. His research interests are in all aspects of burn management,
burn pathophysiology and immunobiology. His clinical and research background make him
uniquely qualified to work as a burns surgeon and scientist at both the bedside and in the
laboratory. Michael is involved as an investigator on many projects and also supervises postgraduate students and
laboratory work.
Dr Jennifer Paratz
MPhty FACP PhD Grad Cert Ed (Medical & Health Sciences)
Chair BTCCRC, Research Fellow
Jennifer has qualifications in clinical physiotherapy, medical education and research. She has
completed a masters, PhD and postdoctoral work in intracranial dynamics in the brain injured
adult and neonate and also a fellowship specializing in cardiopulmonary physiotherapy. She was
previously director of a cardiopulmonary research centre at Alfred Hospital/La Trobe University,
Melbourne and has a large amount of experience in clinical work, research and teaching at both
undergraduate and postgraduate levels. Jennifer has 7 completed doctoral students and is
currently supervising 7 PhD and 3 Master‘s students. She is currently reviewer for a number of high level international
journals and granting bodies and examiner for doctoral awards. She frequently is invited to present at international
conferences and workshops. Jennifer is currently running four randomized controlled trials, is responsible for overall
supervision of postgraduate students, liaison between School of Medicine postgraduate co-ordinator and BTCCRC.
She is also responsible for overseeing the direction and themes of the research centre, large grant applications,
statistical advice, mentoring with grants, manuscript writing and systematic reviews.
3
Professor Keith McNeil
MBBS, FRACP
Chief Executive Officer, Metro North Health Service District
Keith received his training in respiratory medicine in Queensland and underwent sub-specialty
training in cardio-pulmonary transplantation and pulmonary hypertension at Papworth Hospital in
Cambridge, UK. He was recruited to Cambridge as transplant physician and Director of Pulmonary
Vascular Diseases where he was an advisor to the UK Dept of Health on pulmonary hypertension
and established the UK national centre for pulmonary endarterectomy at Papworth Hospital. He
returned to Brisbane in 2001, heading the Transplant Services at The Prince Charles Hospital and was appointed
Associate Professor of Medicine at UQ. His research interests include the effect of brain stem death on pulmonary
vasculature and involvement in clinical trials of new PAH specific drugs. He has authored over 95 publications in the
fields of heart/lung transplantation and pulmonary hypertension. In 2007 he was appointed Professor of Medicine at UQ
and took up the position of CEO at RBWH. In 2008 he became CEO of the Metro North Health Service District, the
largest in Queensland.
Professor David Wilkinson
BSc(Hons) MBChB MSc MD PhD DSc FRACGP FAFPHM FRCP
Dean of Medicine and Head of School of Medicine
David is a specialist in general practice and public health medicine. He was awarded a fellowship
of the Royal College of Physicians (RCP) of London in recognition of distinguished contributions to
medicine. He spent 11 years in Africa as a researcher, public health doctor and medical
superintendent of a 450 bed hospital, focussing on infectious disease epidemiology and
pioneering community based directly observed therapy for TB. He led the development of a major
rural health research enterprise funded by WHO, NIH and the Wellcome Trust. He came to
Australia in 1999 as Foundation Chair in Rural Health at the University of Adelaide for 3 years. He then became PVC
for Health Sciences at the University of South Australia for 2 years where he drove a major organisational restructure.
Currently, he is Dean and Head of the School of Medicine. His research encompasses cardiovascular diseases,
medical education and skin cancer medicine and has authored over 200 publications.
Dr Ian Wilkey
BSc MBBS LLB FRCPA FAFPHM
Director-General of Health and Medical Services, RBWH (retired)
Ian obtained his BSc in 1960 and his medical degree in 1963, both from UQ. He has specialist
qualifications in Pathology and prior to his retirement, he had previously held senior positions in
Queensland Health and the Papua New Guinea health system, including Director of the Laboratory
of Microbiology and Pathology and Director-General of Health and Medical Services. Prior to his
retirement, Ian was Medical Superintendent at Royal Brisbane Hospital. He currently serves on the
RBWH Research Advisory Committee, the Scientific Committee of the Royal Brisbane and Women‘s Hospital
Foundation and the Queensland Institute of Medical Research Human Research Ethics Committee.
Mr Gilberto Maggiolo
Gilberto Maggiolo is a prominent member of the Queensland business community and is
Chairman of Directors and CEO of a number of companies operating throughout Australia, in
civil engineering construction, mining construction, transport industry and commercial property
development. He has had a long and successful career in these industries. From its birth in Mt
Isa in the early 1970‘s, the group has expanded where it now has a presence Australia-wide
and internationally. He is highly respected in industry circles and his companies currently
employ in excess of 1000 people. Gilberto has a long history as a benefactor of charitable
causes, such as Marist Mission Centre in Australia, Fiji, Brazil and New Zealand and San Isidro
Care Centre, Aruligo in Solomon Islands. He is also a very strong supporter of the RBWH Research Foundation.
4
This year, our research centre was awarded the prestigious Fulbright Senior Specialist grant and in so doing, was
successful in attracting Assoc. Prof. Andrew F. Shorr, Associate Director of Pulmonary and Critical Care at the
Washington Hospital Centre and Associate Professor of Medicine at Georgetown University. Assoc. Prof. Shorr
received his undergraduate degree (public policy) from Princeton University, a Masters of Public Health from
Johns Hopkins University and his medical degree from the University of Virginia. His research interests address
healthcare outcomes, epidemiology in pulmonary/critical care and infection in the hospitalized patient. He is an
authority on healthcare outcomes research, a relatively new field requiring expertise in applying aspects of both
traditional and social sciences. Health outcomes research can facilitate the improvement in practice and delivery
of health care thus limiting mortality and/or improving quality of health outcomes for patients.
Whilst here, Assoc. Prof Shorr delivered talks at the RBWH and PAH Grand Rounds, emphasizing the changing
epidemiology and issues related to various types of pneumonia focusing predominantly on nosocomial pneumonia
and the new concept of healthcare associated pneumonia. He delivered the Dean of Medicine‘s Lecture on the
current issues related to Venous Thromboembolism including prevention, diagnosis and management of the condition which can be fatal if not treated.
Senior academic administrators of the university and executive members of RBWH gained much knowledge from
Andrew on pertinent matters such as health outcomes research and how this important research impacts on
health economics. In addition to this, Andrew spoke to researchers at UQCCR and within the Centre for Healthcare Related Infection Surveillance (CHRISP).
We wish to thank the Fulbright commission for funding Andrew‘s visit to our institute and look forward to continued
collaboration with him and the Washington Hospital Centre.
5
RESEARCH
INTERESTS
Department of Intensive Care Medicine
Prof Jeffrey Lipman MBBCh DA FFA FFA (CritCare)
FJFICM MD

management in intensive care, resuscitation of
burns and pharmacokinetics of antibiotic dosage.
Dr Siva Senthuran MBBS BSc FRCA FJFCIM
 renal dysfunction and effect of changes in cerebral perfusion pressure in acute head injury patients on creatinine clearance.
Dr Jennifer Paratz MPhty FACP PhD Grad Cert Ed
(Medical & Health Sciences)
 management and outcome of critically ill and
burns patients, myocardial dysfunction, exercise
and metabolism.
Dr Anthony Holley BSc MBBCh DipPaeds DipDHM
FACEM FJFICM
 identifying alterations in microcirculation during
shock using side stream dark field imaging.
Dr Joel Dulhunty BSc (Hons) MTH MBBS PhD

epidemiology of burn injury and severe sepsis,
study design and methodology.
Dr Jeremy Cohen MBBS BSc MRCP FRCA FJFICM
 adrenal function in critical illness.
A/Prof Robert Boots MBBS (Hons) FRACP FJFICM
PhD Grad Dip Clin Epi MMedSci MHealth Admin IS
 clinical epidemiology, management of burns and
prevention of ventilator associated pneumonia.
Dr John Gowardman BSc BHB MBChB FRACP
FJFICM
 intra vascular access devices, weaning and extubation from mechanical ventilation, aspects of
enteral nutrition and sepsis.
Dr Andrew Udy BHB MBChB PGCert(AME)
 impact of augmented renal clearance on the prescription of antibiotics in the critically ill, acute
kidney injury, microcirculation, severe sepsis/
septic shock and measurement techniques in
ICU
Dr Judith Bellapart MD FJFICM
 cerebral blood flow haemodynamics in patients
on intra-aortic counterpulsation balloon pumps
and Endothelin, as a marker of severity in subarachnoid hemorrhage vasospasm.
Dr Neil Widdicombe MBBS FRCA (UK) FJFICM
 burns management, trauma, ethics in intensive
care and air medial retrieval, documentation of
death for transplants.
Dr Alex Douglas BMedSc MBBS FANZCA

current practice and education in Anaesthesia &
Intensive Care Medicine, pharmacokinetics of
routine antibiotics used in abdominal aortic
aneurism surgery.
Dr Steve O’Donoghue MBChB FANZCA FJFICM
 microcirculation in shocked critically ill patients
during resuscitation and prevention of ventilator
associated pneumonia.
Dr Jayesh Dhanani MBBS MD FJFICM
 antimicrobial therapy, lung infections, inhaled/
aerosol therapy.
Dr Jason Roberts BAppSc BPharm (Hons I) PhD
 pharmacokinetic models for various antibiotics in
critically-ill patients with sepsis using microdialysis, therapeutic drug monitoring.
Hiran Bandeshe BSc BEng
 data mining
Renae Deans BNurs Cert Crit Care
 involved in all projects from protocol writing to
publication, subject recruitment, data collection,
communication and liaison with other study coordinators and study sponsors.
6
Melissa Lassig-Smith Dip App Sc (Nursing) Grad Dip
(Adv Nursing) Grad Dip (Crit. Care) MNursing (Crit Care)
 involvement in all aspects of studies in intensive
care from initial proposal to completion.
Suzie Parker-Scott BSc Hons
 bioanalysis of drugs particularly measurement of
antibiotic and anaesthetic drug levels in all ICU
pharmacokinetic studies.
Dr Peter Thomas BPhthy (Hons) PhD
 cardiorespiratory physiotherapy, intensive care
physiotherapy, patient positioning.
Geetha Kayambu BSc (Phyt)(Hons)

improving Outcomes in Critical Illness with Early
Rehabilitation.
Anita Plaza BPhty (Hons I)
 exercise and metabolism following adult burn injuries.
James Walsh

pulmonary Rehabilitation, lung transplantation,
pulmonary vascular disease, adult survivors of
extreme pre-term birth.
Janine Stuart BNurs

involved with all research currently being completed in ICU, writing proposals, obtaining ethics
approvals, writing grants, data collection and publishing research articles.
Paul Jarrett Dip (He) Nurs
 involved in research studies taking place within
the ICU, from proposal to completion as well as
communication and liaison with study sponsors
and other co-ordinators.
Kellie Stockton BAppSc (Physio) Post Grad Dip
(Cardiothoracic)
 investigating exercise capacity in patients following burn injury particularly, physiological response
to maximal exercise testing in the burn population.
Dr Steve Wallis BSc (Hons) PhD
 bioanalysis of drugs particularly measurement of
antibiotic and anaesthetic drug levels in all ICU
pharmacokinetic studies.
Dr Sia Athanasas BSc MSc (Qual) PhD
 currently provides research co-ordination, research support and management support to the
Centre whilst maintaining research and financial
databases.
Dr Bhavik Patel MBBS MS
 blood stream infections in burns patients.
Dr Rajeev Hegde MBBS MD EDICM FJFICM
Therese Starr Grad Cert Crit Care, Grad Dip Health
Prom
 Certified Clinical research Coordinator involved in
major clinical trials.
7
Bernadette Bissett

Inspiratory muscle training in ventilated patients;
ventilatory weaning; physiotherapy in intensive
care.
Michelle Spermon BOccThy, Acc OT

burns Donor Site Scarring and Compression Garment Therapy.
Department of Anaesthesia and
Peri-operative Medicine
A/Prof Michael Steyn MBChB DRCOG MRCGP
FFARCSI FANZCA MSc
 burns anaesthesia
Dr David Belavy BMedSc MBBS FANZCA
 regional anaesthesia
Dr Paul Gray MBBS FANZCA FFPMANZCA
 acute and chronic neuropathic pain after burn injury, developing the concept of ―Phantom Skin
Pain‖.
Dr Keith Greenland MBBS, FANZCA, FHKCA

difficult airway management, especially emergency surgical airway, fibreoptic intubation, airway
morphology and video laryngoscopy.
A/Prof Kersi Taraporewalla MBBS FANZCA MClinEd
 high fidelity simulation training for crisis management and medical education.
Dr George Pang MBBS FANZCA
 lipid rescue from anaesthetic overdose.
Heather Reynolds BA CertTeach CertCritCareNurs
BHlthSc(Nurs) MN (Admin Anaes & Recovery) MRCNA

management of peripheral arterial catheters in Australian operating theatres
Department of Surgery
Dr William Lukin MBBS FACEM
 triage of older patients in trauma, aged care.
Dr Julian Williams MBBS FACEM
 Sepsis epidemiology and outcomes in ED.
Dr Janet Hou BMed MMed PhD
 emergency system management, ED
overcrowding, triage and trauma.
Dr Victoria Brazil MBBS FACEM MBA
 medical education and training.
Dr Sean Rothwell MBBS, FACEM
 wilderness medicine.
A/Prof Michael Muller MBBS MMedSci FRACS
 scar prevention, injury management, burn prevention, metabolic response to injury.
Dr Michael Rudd MBBS FACS OAM PhD
 aspects of burn management, burn pathophysiology and immunobiology.
RESEARCH
INTERESTS
Department of Emergency Medicine
Professor Anthony FT Brown
MBChB FRCP
FRCSEd FACEM FCEM
 anaphylaxis epidemiology; Acute coronary syndrome (ACS) risk stratification; Sepsis epidemiology; Medical writing and editing.
Dr Louise Cullen MBBS (Hons) FACEM
 chest pain and ACS related diagnoses and management, including biomarkers.
Dr Kevin Chu MBBS MS FACEM
 utility of diagnostic tests in clinical decision making.
Dr Catherine Hurn MBBS FACEM
 massive transfusion in trauma and team training
for trauma.
Dr Jaimi Greenslade BPsych (Hons) PhD
 how workplace stress, culture and fatigue influences nurses performance on one hand and
patient outcomes on the other, involved in all
research projects in ED.
8
9
Throughout 2010, the BTCCRC continued to grow in researchers and project numbers. This growth has
manifested itself in the form of increased funding from the Queensland Emergency Medicine Research
Foundation, the RBWH Private Practice Trust and the RBWH Foundation.
Our clinical research addresses serious questions in the fields of trauma, critical care, burns, emergency
medicine and anaesthesia. The multidisciplinary expertise and collaboration found within our research centre
places us in a coveted position to undertake and succeed in cutting edge research. Our expertise includes
intensivists, burns surgeons, anaesthetists, cardiologists, neurosurgeons, emergency physicians, scientists,
physiologists, nutritionists, physiotherapists and intensive care nurses. A number of hospital staff have
undertaken or are currently undertaking postgraduate degrees within our centre or combine clinical work with
research.
RESEARCH
THEMES
Our laboratory research is closely allied with our clinical research. The major themes developing within the
centre are:
1.
2.
3.
4.
5.
6.
7.
8.
Antibiotic resistance and infection control in the critically ill.
Pharmacokinetics and drug distribution in the critically ill.
Management and outcome of critically ill, trauma, head injury
and long stay ICU patients.
Critically ill patients with renal dysfunction.
Management and outcome of burns patients including pain
control, myocardial dysfunction, exercise and metabolism and
fluid and nutritional management post burn.
Anaesthesia.
Emergency medicine.
Multi-centre trial collaborations.
10
including MRSA, VISA, VRE and S. pneumoniae.
Cooper MA, Paterson DL, Roberts JA, Schlaes D .
Fundor: Wellcome Trust Seeding Drug Discovery Award
1. Antibiotic resistance and
infection control in the critically ill
Antibiotic resistance has long been recognized as a
potential threat to successful treatment of infectious
diseases. Antibiotic resistant infections commonly occur
in long stay, debilitated patients and contribute to
increased risk of death, longer ICU and hospital stay,
further weakness and long term dysfunction. This
problem also contributes to patients being unable to be
discharged from intensive care and/or hospital and so
exacerbating the shortage of acute hospital beds and
increases in surgery waiting time.
Projects addressing antibiotic resistance and infection in
the critically ill include:
Predicting the risk of invasive candidiasis in critically ill
patients. Sorrell TC, Lipman J, Playford EG, Jones M,
Iredell JR, Paterson D, Marriott D
Fundor: NHMRC
2. Pharmacokinetics and drug distribution in the
critically ill
Critically ill patients often have varying physiological
needs to an average patient and often require different
dosages of antibiotics and other drugs, particularly if
they are on renal replacement therapies. Professor
Lipman has pioneered work that demonstrates that
patients in intensive care are not receiving enough
antibiotics to achieve optimal levels to kill pathogens.
There is also a controversy over whether bolus dosing
or continuous infusion of β-lactams is more effective in
antibiotic delivery in critically ill patients. This centre is
using an in vivo technique, microdialysis, that permits
monitoring of local concentrations of drugs and
metabolites at sites in the body other than within the
blood stream, in an attempt to answer this controversy.
Multi-centre Australian and New Zealand study of
antibiotic utilisation in the ICU. Lipman J, Dulhunty J,
Paterson D
Projects which are investigating pharmacokinetics and
drug distribution in the critically ill are:
Antibiotic cycling in intensive care. Iredell J, Gallagher J,
Lipman J, Boots R, Gilbert L
Fundor: RBWH Foundation
Drug dosing in the ―at risk‖ critically ill patient. Lipman
J, Roberts MS, Paterson D, Kirkpatrick CMJ, Kruger P,
Roberts JA
Fundor: NHMRC
An International Epidemiological Study of Candidaemia
in a Critical Care Population Holley A, Dulhunty J,
Lipman J, Dancer C
Fundor: RBWH Foundation
Estimation of drugs, peptides and metabolites using
HPLC- Mass-spectrometry-microdialysis. Roberts M,
Cross S, Lipman J, Colditz P, Rudd M, Dalley A
Fundor: Mayne Bequest Fund
Multi-drug resistant Acinetobacter: an emerging
noscomial pathogen. Schembri M, Lipman J, Nimmo G,
McEwan A, Jennings M
Fundor: RBWH Foundation, RBWH
Microdialysis for pharmacokinetic modeling of
Piperacillin Tazobactam & Meropenem (continuous
infusion or intermittent bolus dosing) in critically ill
septic patients. Roberts J, Lipman J, Cross S, Dalley
A, Roberts M
Fundors: Australian and New Zealand College of
Anaesthetists (ANZCA), RBWH Foundation
Transmissible resistance in bacteria: effect of antibiotic
selection pressure. Iredell JI, Partridge S, Lipman J,
Gilbert GL
Is empiric anti-enterococcal therapy necessary?
Implications and outcome from an Antibiotic Cycling
Study in the ICU. Chatterjee I, Dulhunty J, Lipman J
Membrane-targeted antibiotic for the treatment of skin
and lung infections caused by drug resistant pathogens
11
Pharmacokinetics of cephalothin, vancomycin and
gentamycin used for antimicrobial prophylaxis during
elective abdominal aortic aneurysm surgery. Douglas
A, Roberts J, Lipman J
Fundors: RBWH, ANZCA
Imaging of the microcirculation using the Microscan
(orthogonal polarization spectral imaging) and providing
improved quality of drug analysis for PK studies in
critically ill patients. Lipman J, Paratz J, Boots R, Muller
M, Dalley A
Fundors: NHMRC/UQ, RBWH Foundation/Wormald
Infection and Survival Imperative – The need for
antibiotic dose optimisation in critically ill patients
receiving dialysis. Roberts J
Fundor: The Clive and Vera Ramaciotti Foundation, UQ
New Staff Start up grant.
DALI – Defining Antibiotic Levels in Intensive care unit
patients. Lipman J, Wallis S, Roberts J, Dimopoulos G,
Martin C, Rello J .
Fundor: RBWH, European Society of Intensive Care
Medicine.
3. Management and outcome of critically ill, head
injury and long stay ICU patients
Eurotherm: Investigating the effect of therapeutic mild
hypothermia on the pharmacokinetics of drugs in
Traumatic Brain Injury (TBI) patients. Roberts J, Wallis
S, Andrews P.
Fundor: RBWH
Pilot RCT of continuous β-lactam infusion compared
with intermittent dosing in critically ill patients. Lipman J,
Webb SAR, Dulhunty J, Myburgh J, Bellomo R,
Paterson D, Roberts J, Gomersall C
Fundor: Australia and New Zealand Intensive Care
Society (ANZICS)
Continuous versus intermittent β-lactam antibiotic
dosing in critically ill patients: determining the evidence
via a step-wise program of research. Dulhunty J,
Lipman J, Paterson D, Roberts J, Webb S, Myburgh J,
Bellomo R, Gomersall C, Davis J, Shirwadkar C.
Fundor: RBWH
An investigation of PK-PD characteristics of various βlactam antibiotics in patients with sepsis using
microdialysis. Peake S, Robertson T, Lipman J, Roberts
J, Roberts M.
Fundor: The Queen Elizabeth Hospital (TQEH)
Research Foundation
Pharmacokinetics of broad spectrum antibiotics in
extracorporeal membrane oxygenation (ECMO) – using
plasma concentrations to optimize antibiotic therapy.
Welch S, Roberts J, Burrows F, Levkovich B, Ray J,
Pellegrino V, Bui T, Wallis SC, Marriott D, Rudham S.
Fundor: Society of Hospital Pharmacists of Australia
(SHPA), RBWH Foundation
Antibiotics in critically ill patients - dosage adjustments
in renal failure and during continuous veno-venous
haemodialysis. Roberts J
Fundor: The Charles and Sylvia Viertel Charitable
Foundation
Patients who survive intensive care often are weak,
debilitated and with a poorer quality of life compared to
their pre morbid status. We are actively investigating
methods to prevent weakness and loss of function in
long stay intensive care patients. There are also many
projects investigating the optimum delivery of standard
procedures to ensure that the best quality of care is
offered to intensive care patients.
The damage occurring to the central nervous system in
head injury and subarachnoid haemorrhage often
impacts on other systems. For this reason we are
investigating how active management of cerebral
perfusion pressure impacts on renal function.
Projects which are investigating management of head
injury, critically ill and long stay intensive care patients
are:
Optimal pattern of manual hyperinflation in the
ventilated patient. Paratz J, Thomas P, Savian C,
Lipman J
A point prevalence survey of venous thromboembolism
prophylaxis management in the critically ill and an
epidemiological observational audit of venous
thromboembolism prophylaxis management in critically
ill patients with severe sepsis (VTE AUDIT).
Gowardman J
The clinical experience of nitric oxide use in the adult
ICU at the RBWH. Boots R
11-β-hydroxysteroid dehydrogenases activity in critical
illness. Cohen J
Fundor: ANZCA
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Trial of Steroids in Septic Shock. Cohen J, Venkatesh B,
Finfer S, Myburgh J, Webb S.
Fundor: NHMRC
Assessment of Functional Adrenal Status in Patients with
Septic Shock. Cohen J, Venkatesh B.
Fundor: RBWH
Early proactive rehabilitation in intensive care: RCT
Paratz J Boots R, Chang A, Lingwood B, Thomas P,
Lipman J
Fundors: University of Queensland, RBWH Foundation
Developing a research base for intravenous peripheral
catheter resites. The DRIP trial. Rickard C, Webster J,
Gowardman J, Wallis M, McCann D
Fundor: NHMRC
SAVED - Study of practices and complications
associated with central venous and arterial
catheterisation in an ICU population. Gowardman J,
Rickard C
Endothelin, a marker of severity in subarachnoid
hemorrhage vasospasm. Bellapart J, Fourie C, Stuart J,
Boots R, Paratz J
Crystalloid versus Hydroxy-Ethyl Starch Trials (CHEST).
Myburgh JA, Finfer SR, Bellomo R, Lipman J, Webb S,
Liu B
Fundor: NHMRC
Can exercise reduce risk factors for oesophageal
cancer? Winzer B, Paratz J, Stockton K, Whiteman D
Fundor: QLD Health Health Practitioner Research grant,
Wesley Research Institute, Good Life Health Clubs
Mechanisms of fatigue in systemic lupus erythematosus.
Stockton K, Kandiah D, Paratz J
Fundor: APA Scholarship for K Stockton
Pre-clinical testing of the AutoStart Burette for use with
intravascular devices: comparison with standard burette
technology. Rickard C, Webster J, McMillan D, Wallis S,
Zhang L, Marsh N
Fundor: Griffith University Industry Collaborative Scheme
Effect of intravenous glutamine in trauma
patients receiving enteral nutrition: a prospective doubleblind randomized clinical trial. Al Balushi R, Paratz J,
Cohen J, Banks M
Fundor: UQ Research Scholarship for R Al Balushi,
RBWH Foundation, Fresenius Kobe
13
Assessment of the Microcirculation in Shocked Critically
Unwell Patients during the First 24 hours of
Resuscitation. Holley A, Udy A, Boots R, Paratz J,
O‘Donoghue S, Douglas A, Roberts J, Hurn C, Lukin B,
Lipman J.
Fundor: RBWH Foundation/Wormald
Exogenous melatonin in critically ill patients: the impact
on sleep and ICU psychosis. Bellapart J, Boots R,
Zappala C, Paratz J, Morrison S, Brown M.
Fundor: RBWH
The tyranny of distance: exploring contributory factors for
delays in transfer and intervention in multi-trauma
patients. Wullschleger M, Pollard C, Dulhunty J, Paratz J,
Hosein S, Bandeshe H, Elcock M, Rashford S.
Fundor: RBWH
Inspiratory Muscle Training for ventilated patients. Bissett
B, Paratz J, Boots R, Leditschke A.
i-PERFORM Trial—Mobilising the Critically Ill:
Physiological and Functional Outcomes following Early
Rehabilitation in Sepsis. Kayambu G, Paratz J.
An audit of select indices of injury severity including the
Injury Severity Score; the Trauma and Injury Severity
Score and the Revised Trauma Score of trauma patients
managed in the Royal Brisbane & Women‘s Hospital from
2003-2005 to establish the potential to determine a
requirement for Intensive Care Unit involvement.
Holley,A, Douglas A
4. Critically ill patients with renal dysfunction
This relatively new area of collaboration with the Department of Renal Medicine investigates issues of drug
dosage, weaning from mechanical ventilation and
overall outcome in critically ill patients with existing
renal dysfunction. We are currently addressing these
important issues using novel markers for the estimation of plasma volume/liver blood flow, estimation of
glomerular filtration rate and total body water.
Projects associated with this area are:
Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD Study).
Varghese J, Ranganathan D, Roberts J, Lipman J,
Healy H, Fassett R, Wallis S.
Pharmacokinetics in CVVHDF-using plasma and tissue
antibiotic concentrations to optimize dosing of β-lactam
antibiotics. Varghese J, Lipman J, Roberts J.
Fundor: RBWH Foundation
The impact of augmented renal clearance on the prescription of antibiotics in the critically ill. Udy A, Lipman
J
Fundor: RBWH PhD Scholarship for A Udy
Antibiotics in critically ill patients - dosage adjustments
in renal failure and during continuous veno-venous
haemodialysis. Roberts J, Lipman J, Varghese J.
Fundor: Sylvia and Charles Viertel Charitable Foundation Clinical Investigatorship
Infection and Survival Imperative – The need for antibiotic dose optimisation in critically ill patients receiving
dialysis. Roberts J, Lipman J, Varghese J
Fundor: UQ New Staff Research Start Up Grant, Ramaciotti Foundation
Augmented Renal Clearance in the Intensive Care Unit.
Udy A, Lipman J, Roberts J, Boots R.
Fundor: RBWH Foundation
5. Management and outcome of burns patients including pain control, myocardial dysfunction, exercise and metabolism and nutritional management
post burn.
pain, but in the long term cosmetic and functional issues. As a means of improving the treatment and outcomes of these patients, the Burns Unit at RBWH, one
of the largest in Australia, has instituted a large number
of studies investigating initial cardiac function, management of pain, antibiotic efficacy, nutrition issues, exercise post burns, prevention of heterotopic ossificans.
With increased collaboration with other burns units in
Australia, improvement in both the survival and health
outcomes of burns patients will be achieved.
Projects which aim to improve the management and
outcome of burns patients include:
Randomised placebo controlled trial of pregabalin in the
treatment of neuropathic pain following severe burn injury in humans. Gray P, Williams B, Lipman J,
Cramond T
Neurotransmitters and pain receptors following burn
injury in a pre-clinical model and assays of pain medicines and their metabolites both in the clinical and preclinical model. Gray P, Lipman J, Cramond T
The analysis of morphine perfusion in burned and normal tissue using microdialysis in burn injured patients.
Gray P, Cross S, Dalley A, Muller M, Lipman J,
Cramond T
A survey of patients with healed burn injury to determine
the incidence and impact of persistent pain. Gray P
Metabolism and exercise post-burn injury. Muller M,
Paratz J, Rudd M, Lipman J, Plaza A, Boots R.
Fundor: RBWH Foundation/Wormald
Improving donor site epithelisation and scar maturation
times following split skin grafting in burns patients: a
novel research study using compression therapy. Rudd
M, Spermon M
Fundor: RBWH & RBWH Foundation/Wormald
Development and evaluation of an adult burns prevention program. Muller M, Paratz J, Dulhunty J.
Fundor: Statewide Trauma Clinical Network
Exercise testing in the chronic critically ill patient
Paratz J, Stockton K, Boots R.
Thermal injury is a devastating injury, not only for the
immediate concern of risk of loss of life and extreme
14
Diagnostic markers of sepsis in burns. Paratz J, Boots R,
Paterson D, Lipman J, Muller M.
Fundor: RBWH Foundation
Myocardial function post-burn injury. Paratz J, Lipman J,
Boots R, Muller M, Rudd M, Deans R, Widdicombe N,
Parsonage W
Fundor: RBWH
Indirect Calorimetry to monitor changes in energy requirements of adult burn patients. Forbes S, Ash C, Muller M, Paratz J, Rudd M, Lipman J
Blood stream infections and optimising β-lactam antibiotic dosing in burns patients. Patel B, Mallet T, Roberts
J, Paratz J, Muller M, Rudd M, Dulhunty J, Lipman J,
Paterson D.
Can adrenergic blockade improve outcome in burns?
Muller M, Paratz J, Roberts J, Dhanani J, Towsey K,
Younger J.
Fundor: RBWH
6.
Anaesthesia
This area of research has experienced significant growth
in the last 5 years and continues to do so. A key area of
focus is the ongoing research and teaching in Airway
Management – understanding and also translating this
into everyday clinical practice. A new project on board is
investigating the neurotoxicity of ultrasound gels.
Projects include:
Feedback Performance for Clinicians . Taraporewalla K
Impact of Single Episode of Knowledge Retrieval Skills.
Michener K, Taraporewalla K, Reynolds H (completed)
Haemodynamic change associated with positioning of
the Andrew‘s Spinal Table. Cumpston P, Antoniazzi P
Comparison of the C-Trach, Classic Laryngeal Mask and
Proseal Laryngeal Mask with the Aintree Catheter
against Direct Laryngoscopy with the Single-Use Bougie
for Simulated Unstable Cervical Spine Injuries.
Greenland K, Edwards M, Tan H, Donaldson A, Irwin M,
Reynolds H (completed/published)
The Vocal Cord – Carina Distance in Anaesthetised
Adults and Its Clinical Implication on Tracheal Tube Design. Pang G, Greenland K (completed/published)
15
Survey of Rural Anaesthetists‘ Management of Tracheal
Intubation for Patients With Difficult Airways. Eley V,
Greenland K, Lloyd B, Reynolds H (completed/
published)
Changes in airway configuration with different head and
neck positions using magnetic resonance imaging of
normal airways. Greenland K, Edwards MJ, Hutton N,
Challis V, Irwin MG, Sleigh J (completed/published)
Fundor: ANZCA
A reappraisal of the sniffing position and the Three-axes
Alignment Theory for direct laryngoscopy – s. Greenland
K, Edward M (completed/published)
Fundor: ANZCA
A Real-time and Self-Adaptive Stream Data Analyser for
Intensive Care Management. Zhang Y, Yi X, He J,
Pang C, Steyn M.
Fundor: Australian Research Council (ARC)
Ultrasound transmission gel: an assessment of neurotoxicity. Belavy D, Sunn N, Lau Q, Robertson T.
Fundor: ANZCA
7. Emergency medicine
The Department of Emergency Medicine‘s (DEM) research focus centres around improving outcomes and
evaluating new processes for treating patients in the
Emergency Department. Again, this year the research
teams were hugely successful in securing funding from
the QEMRF.
Projects include:
The Sepsis Registry: A prospective database to characterise and facilitate improved outcome for admitted
patients with community-acquired infection. Williams J,
Paterson D, Lipman J, Greenslade J, Brown A, Paratz
J, Dulhunty J, Chu K.
Fundor: QEMRF
Accelerated pathway in the assessment of acute coronary syndrome in the DEM. Cullen L, Brown A, Than
M, Greenslade J, Hammett C, Hou X-Y, Ungerer J,
Chu K, Parsonage W.
Fundor: QEMRF, RBWH Foundation
Evaluation of a new massive transfusion protocol for
exsanguinating trauma patients. Hurn C, Muller M,
Cook S, Chu K, Greenslade J, Hou X-Y, Campbell D,
Holley A, Rowell J.
Fundor: Statewide Trauma Clinical Network
End-of-Life Issues – Withdrawal of treatment/Decision
not to treat in the Emergency Department: A retrospective multi-centre review. Richardson P, Chu K, Greenslade J.
Fundor: QEMRF
Medication and fluid orders in the Emergency Department: Examining the incidence of error and adverse
events. Richardson P, Greenslade J, Doran E, Chu K
Fundor: QEMRF
Assessment of the microcirculation in shocked critically
unwell patients during the first 24 hours of resuscitation. Holley A, Lukin B Hurn C, Holley A, Greenslade J,
Lipman J, Paratz J, Udy A, Boots R, Chu K
Fundor: QEMRF
A comparison of the implementation of interventions
for controlling laboratory blood test ordering in four
Queensland Teaching Hospital Emergency Departments. Chu K, Spain D, Aitken P, McNeil I, Greenslade J, Lind J, Furyk J, Sinnott M, Hansen D, O‘Dwyer M, Mallit K-A, Ford M, Rothwell S, Cullen L, Hou
X-Y, Brown A, FitzGerald G.
Fundor: QEMRF
Triaging older major trauma patients in the Emergency
Department. Lukin W, Chu K, Greenslade J, Hou X-Y,
Brown A.
Fundor: Statewide Trauma Clinical Network
A randomized controlled trial comparing patient controlled sedation (PCS) versus physician controlled sedation with propofol in patients requiring procedural
sedation in ED. Bell A, Chu K, Lipp T, Duncan A, Rothwell S.
Fundor: QEMRF
Validation of CARING criteria: A diagnostic accuracy
study for predicting who should have an Advance
Health Directive (AHD). Richardson P, Chu K, Greenslade J.
Fundor: QEMRF
16
Tamsulosin for the treatment of Distal Ureteric Calculi: A
double-blinded, placebo-controlled, randomised, multicentre trial. Furyk J et al
Fundor: QEMRF
A comprehensive evaluation of a hospital in nursing
home program in three Queensland hospitals. Lukin W,
Hou X-Y et al
Fundor: QEMRF
Factors influencing triage allocation for patients with
acute myocardial infarction. Ryan K, Cullen L, Greenslade J, Chu K, Brown ATF.
Fundor: RBWH Foundation
Rapid assessment of cardiac chest pain: The Australia
and New Zealand Assessment of chest Pain Rule
(ANZAP rule): A prospective validation study. Cullen L,
Brown AT, Greenslade J, Chu K, Hou J, Parsonage W,
Graves N, Than M, Tate J.
Fundor: QEMRF
Prevalence and risk factors associated with CA-MRSA in
Queensland Urban Emergency Departments: A prospective study. Williams J, Paterson D, Nimmo G, Greenslade J, Doucet K, Chu K.
Fundor: QEMRF
8. Multi-centre trial collaborations
The RBWH Department of Intensive Care Medicine, Department of Emergency Medicine and the Burns Trauma
& Critical Care Research Centre are site investigators for
the following multi centre trials.
The extended study on prevalence of infection in intensive care: EPIC II.
Principal Site investigator: J Lipman
Multicentre, unblinded, randomised, controlled trial to
assess the effect of augmented vs. normal continuous
renal replacement therapy (CRRT) on 90-day all-cause
mortality of intensive care unit patients with severe
acute renal failure (ARF) (RENAL study).
Principal Site Investigator: R Boots
Safe translation of research into practice study (SAFE
study).
Principal Investigator: J Lipman
17
ASia Pacific Evaluation of Chest pain Trials (ASPECT
study).
Principal Site Investigator: L Cullen
DALI – Defining Antibiotic Levels in Intensive care unit
patients.
Principal Site Investigator: J Lipman, J Roberts, S Wallis
Continuous Monitoring of Acute Non-Specific Immunoinflammatory Response using SeptiCyte®Lab to Determine the Relationship Between Inflammatory Index
and Clinical Progression and Outcome Measures.
Principal Site Investigator: J Lipman
CHEST: A multi-centre randomised controlled trial of
fluid resuscitation with starch (6% hydroxyethyl starch
130/0.4) compared to saline (0.9% sodium chloride) in
intensive care patients on mortality.
Principal Site Investigator: J Lipman
Australian Resuscitation In Sepsis Evaluation (ARISE):
A randomised controlled trial comparing early goal directed therapy to standard care for patients in septic
shock.
Principal Site Investigator: J Williams
Conscious 2: A prospective, multi-centre doubleblinded, randomized, placebo-controlled, parallel-group
study to assess the efficacy and safety of clazosentan
in reducing vasospasm-related morbidity and all-cause
mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by surgical clipping.
Principal Site Investigator: J Bellapart
Conscious 3: A prospective, multi-centre, doubleblinded, randomized, placebo-controlled, parallel-group
study to assess the efficacy and safety of Clazosentan
in reducing vasospasm-related morbidity and all-cause
mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by endovascular coiling.
Principal Site Investigator: J Bellapart
ARTISAN: A randomized, double-blinded, placebocontrolled, phase 2B study to assess the safety and
efficacy effects of ART-123 on subjects with sepsis
and disseminated intravascular coagulation.
Principal Site Investigator: J Gowardman
PROWESS II: Efficacy and Safety of Drotrecogin Alfa
(Activated) in Adult Patients with Septic Shock - A randomized, double-blinded, placebo-controlled, multicentre, Phase 3 study of drotrecogin alfa (activated) administered as a continuous 96-hour infusion to adult patients
with septic shock.
Principal Site Investigator: R Boots
Augmented Renal Clearance in The Intensive Care
Study (ARCTIC)
Principal Site Investigator: A Udy
18
DEAN’S AWARD WINNER – Jason Roberts
Dr Jason Roberts is a clinical pharmacist who became interested in research in
critical care whilst working at RBWH. He found that there was little data available to guide clinicians for rational antibiotic dosing. Inspired by the Director of
the BTCCRC and Head of Intensive Care Medicine at RBWH, Professor Jeffrey Lipman, he decided to undertake a PhD. The clinical and academic nature
of the RBWH Intensive Care Unit and the BTCCRC provided the perfect opportunity to successfully address the deficiencies in data to guide appropriate antibiotic treatment in an attempt to lower the mortality rate of critically ill patients.
After completing his thesis, Dr Roberts has elected to remain at the BTCCRC,
as its efficient structure enables valuable descriptive clinical research to be
conducted in a timely manner. Dr Roberts is the Team Leader of the Clinical
Pharmacokinetics and Pharmacodynamics Group in the centre and currently
holds over 20 grants and has published in excess of 50 journal articles and 8
book chapters—an impressive achievement in such a short research career
span.
NEW ANAESTHESIA RESEARCHER GETS ANZCA FUNDING –
David Belavy
Regional anaesthetic techniques have become more popular
now that ultrasound (US) imaging can be used to guide the
needle with greater accuracy and safety. US transmission gel
is used to improve image quality when performing US guided
nerve blocks. Some gel can be carried by the needle to the
nerve during the process of needle insertion. US gels may
contain substances known to cause nerve damage like glycerol and propylene glycol. Currently there are no published
human or animal studies looking at whether US gel could
cause nerve damage. This gap in our knowledge means that
anaesthetists may be inadvertently exposing their patients to
the risk of nerve injury in their effort to improve pain relief. By
using an animal model, we will measure the concentration of
glycerol and propylene glycol in a variety of sterile gels used
in anaesthesia and test if US gel causes damage to nerves.
US gel will be injected around nerves using micro-ultrasound techniques similar to those applied in clinical nerve
blocks. Neuropathologists will then examine the nerves using light and electron microscopy for changes consistent
with nerve damage. This study will be the first assessment of neurotoxicity associated with US gel. The results will
guide anaesthetists in performing nerve block techniques with the greatest safety for patients. The study involves
collaboration between the Departments of Anaesthesia and Pathology at the RBWH, the Ultrasound Core Facility of
the Queensland Brain Institute and the BTCCRC.
Researcher
19
DON’T BE A FLAMIN’ FOOL – BURNS PREVENTION CAMPAIGN
IS A SUCCESS - Michael Muller
Assoc. Prof Michael Muller and his team from BTCCRC,
along with Dr John Harrison and Bruce Redman, from the
School of Journalism and Communication, worked together
to develop the ―Don‘t be a flamin‘ fool‖ campaign. The campaign utilised graphic television commercials and newspaper
ads to reduce the incidence of young males being burned by
throwing petrol on campfires, bonfires and outdoor BBQs.
The two week burns prevention campaign had been trialled
in regional Queensland as part of a study funded by the
Statewide Clinical Trauma Network, to evaluate the effectiveness of a targeted prevention message. Supported by
data from an 11-year study of patients admitted to the
RBWH Burns Unit with new burn injuries, the project included interviews with doctors, burns victims and their families. The study observed that a media prevention message had a significant impact on burn safety knowledge. In
follow-up telephone interviews, 83 percent of respondents who had seen the campaign thought it was effective in
getting its message across. Assoc. Prof Muller was awarded several prizes for this innovative study.
SEPSIS AT THE COAL FACE – Julian Williams
Bemused by the many more questions than answers provided by the Rivers Early Goal Directed Therapy
(EGDT) study, Julian has initiated Emergency Department
involvement in a variety of projects designed to further our
understanding and improve management of patients presenting with infections. A Sepsis Registry has been established to collect detailed clinical, microbiological and outcomes data on all patients admitted with infections over a
three year period, with studies resulting from this registry
forming the basis of a PhD thesis. The Emergency Department is also involved in the recruitment of patients with septic shock into the multicentre ARISE trial, an RCT comparing EGDT with standard resuscitative management. In the
near future, enrolment will commence for a study designed
to quantify prevalence and risk factors for CommunityAssociated MRSA (CA-MRSA) in patients admitted with skin
and soft tissue infection.
Showcase
20
Grant Title
Granting Body
Investigators
Amount
Prevalence and risk factors
associated with CA-MRSA in
Queensland Urban Emergency
Departments: A prospective
study
QEMRF
Williams J, Paterson D, Nimmo
G, Greenslade J, Doucet K, Chu
K
$94 100
Rapid assessment of cardiac
chest pain: The Australia and
New Zealand Assessment of
chest Pain Rule (ANZAP rule):
A prospective validation study
QEMRF
Cullen L, Brown AT, Greenslade
J, Chu K, Hou J, Parsonage W,
Graves N, Than M, Tate J.
$581 223
Fulbright Senior Specialist
Grant
Lipman J
Ultrasound transmission gel: an
assessment of neurotoxicity.
ANZCA
Belavy D, Sunn N, Lau Q,
Robertson T
A Real-time and Self-Adaptive
Stream Data Analyser for Intensive Care Management
ARC Linkage
Effect of Intravenous Glutamine
Supplementation in Trauma
Patients Receiving Enteral Nutrition: A Prospective DoubleBlind Randomized Clinical Trial
Health outcomes research
$21 249
Zhang Y(UV), Yi X, He J, Pang
C (AEHRC), Steyn M
$345 000
RBWH Foundation
Banks M, Paratz J, Cohen J, AlBalushi R, Roberts J
$23 000
Trial of Steroids in Septic Shock
NHMRC Project grant
Cohen J, Venkatesh B, Finfer S,
Myburgh J, Webb S.
$3.4 million
Accelerated pathway in the assessment of suspected acute
coronary syndrome in the Emergency Department.
RBWH Foundation
Cullen L, Greenslade J, Parsonage W, Brown A
$20 000
Continuous versus intermittent
β-lactam antibiotic dosing in
critically ill patients: determining
the evidence via a step-wise
program of research
RBWH Foundation
Dulhunty J, Lipman J, Paterson
D, Roberts J, Webb S, Myburgh
J, Bellomo R, Gomersall C, Davis
J, Shirwadkar C.
$35 000
The tyranny of distance: exploring contributory factors for delays in transfer and intervention
in multi-trauma patients
RBWH Foundation
Wullschleger M, Pollard C, Dulhunty J, Paratz J, Hosein S, Bandeshe H, Elcock M, Rashford S
$35 000
Can adrenergic blockade improve outcome in burns?
RBWH Foundation
Muller M, Paratz J, Roberts J,
Dhanani J, Towsey K, Younger J
$35 000
DALI—Defining Antibiotic levels
in Intensive care Unit patients
ESICM
Lipman J, Dimopoulos G, Martin
C, Rello J, Roberts J, Wallis S
$26 000
Pharmacokinetics of Enteric
Coated Mycophenolate Sodium
in Lupus Nephritis
RBWH Foundation
Ranganathan D, Roberts JA,
John G, Fassett R, Healy H, Lipman J, Kubler P, Ungerer J.
$30 000
Changes in airway configuration
with different head & neck positions using magnetic resonance
imaging of normal airways
ANZCA
Greenland B, Edwards M, Hutton
N, Challis V, Irwin M
$20 000
21
Grant Title
Granting Body
Investigators
Amount
NHMRC Project
Rickard C, Wallis M, Young J,
Gowardman J, Whitby M, Fraser
J, McMillan D, Zhang L.
$1 555 305.30
DALI – Defining Antibiotic Levels in Intensive care unit patients
RBWH Foundation
Lipman J, Wallis S, Roberts J.
$40 000
Eurotherm: Investigating the
effect of therapeutic mild hypothermia on the pharmacokinetics of drugs in Traumatic Brain
Injury (TBI) patients
RBWH Foundation
Roberts J, Wallis S, Andrews P.
$30 000
Exogenous melatonin in critically ill patients: the impact on
sleep and ICU psychosis
RBWH Foundation
Bellapart J, Boots R, Zappala C,
Paratz J, Morrison S, Brown M.
$40 000
Assessment of Functional
Adrenal Status in Patients with
Septic Shock
RBWH Foundation
Cohen J, Venkatesh B
$25 000
Membrane-targeted antibiotic
for the treatment of skin and
lung infections caused by drug
resistant pathogens including
MRSA, VISA, VRE and S.
pneumoniae.
Wellcome Trust Seeding
Drug Discovery Award
Cooper MA, Paterson DL,
Roberts JA, Schlaes D
$5 046 982
Intravascular Device administration sets: Replacement
after standard versus prolonged use (RSVP Trial).
Wormald Security
Edward Life Sciences
Astra Zeneca
$50 000
$24 000
$10 000
BTCCRC Research Supervision
Title
Name
Degree
BTCCRC Supervisor
Ms
Ms
Winzer, B
Stockton, K
PhD
PhD
Paratz J
Paratz J
Ms
Al-Balushi R
PhD
Paratz J/Cohen J
Ms
Kayambu, G
PhD
Paratz J/Boots R
Ms
Bissett, B
PhD
Paratz J/Boots R
Mr
Walsh, J
PhD
Paratz J
Dr
Patel, B
MPhil
Paratz J/Roberts J
Dr
Williams, J
PhD
Lipman J
Dr
Udy, A
PhD
Lipman J/Boots R
Ms
Spermon, M
MPhil
Muller M
Dr
Gray, P
PhD
Lipman J
Ms
Varghese, J
PhD
Lipman J/Roberts J/Boots R
Ms
Ulldemolins, M
MPhil
Roberts J/Lipman J
Mr
Jarugula, R
PhD
Brown A/Lipman J
22
Brooke Winzer
Paul Gray
Julie Varghese
Physiotherapist
PhD Student
Anaesthetist
PhD Student
Clinical Pharmacist
PhD Student
Barrett‘s oesophagus is an acquired condition in which cells
lining the oesophagus transform
into cells resembling the lining
of the intestines. The condition
is a risk factor for cancer of the
oesophagus and is therefore
considered a pre-malignant
condition.
My study aims to determine
whether exercise can influence
the progression of Barrett‘s oesophagus to oesophageal cancer via reducing cancer biomarkers. An increase or decrease in biomarkers will be
used to indicate whether exercise is beneficial in reducing
cancer risk.
Following two years of hard work
in the gym, my PhD study is almost coming to an end. Recruitment of obese males with Barrett‘s oesophagus, was completed in September 2010. Thirty
-three participants were randomly
allocated to an exercise intervention or control arm involving 24
weeks of either moderateintensity aerobic and resistance
training or a low-intensity stretching program. The effect of the
exercise program on metabolic
biomarkers associated with cancer development will be determined by May 2011.
STUDENT
SHOWCASE
23
My PhD thesis reviews the literature on the mechanism, epidemiology, assessment and treatment
of pain after burn injury in animal
models and in the clinical setting.
This includes developing the concept of ―Phantom Skin Pain‖ as a
term that accurately reflects the
underlying pathology and the
experience of the individual with
acute and persistent pain after a
severe burn injury. The majority
of the thesis will detail the methodology and results of a randomised placebo-controlled trial of
pregabalin in burns patients for
the management of pain and to
also determine if this intervention
assists in preventing long-term
pain. Finally, a measure of pain
assessment in the burn injured
patient will be proposed that incorporates an assessment of
different descriptors of pain, procedural pain and itch as well as
the psychological impacts of severe burn injury.
Continuous Venovenous Haemodiafiltration (CVVHDF), a form of
dialysis is commonly used in
ICU. Recent studies have highlighted the importance of antibiotic dosing of critically ill patients
with renal failure showing inappropriate dosing of patients, exposing them to treatment failure
and higher mortality rates. My
project aims to study the distribution and clearance of β-lactam
antibiotics in critically ill patients
undergoing CVVHDF, in an effort
to optimise drug dosing.
We are currently enrolling critically ill patients with acute kidney failure on CVVHDF to study
the distribution and clearance of
β-lactam antibiotics. I am also
working in collaboration with the
Renal Department at RBWH on
a project studying the pharmacokinetics of intraperitoneally
administered antibiotics in peritoneal dialysis patients with peritonitis. Both pharmacokinetic
studies are progressing well and
I am in the process of analysing
the collected samples in our
Bioanalysis Laboratory. We
hope to use the results from
these studies to develop dosing
recommendations to assist clinicians and pharmacists to optimize dosing of these antibiotics
in clinical practice for patients
with kidney failure undergoing
different types of dialysis.
Students Enrolled in
Other Schools who
are co-supervised
by our staff
Lawrence Caruana (SOMC) MPhil
Electrical impedance tomography &
positioning. Supervisors - A/Prof J
Fraser, Dr J Paratz, Dr A Chang
Brooke Wadsworth (SHRS) MPhil.
Abdominal bracing in spinal patients. Supervisors - Dr J Paratz,
Dr T Haines
Claire Prentice (SHRS) PhD.
Muscle weakness in intensive care
Supervisors—Dr J Paratz, Dr A
Bersten
David Koh (University of Tasmania) PhD. Vascular access. Supervisor—Dr J Gowardman
Niall Higgins (Skills Development
Centre) PhD. Videoconferencing
education and overseas trained
specialists. Advisors—A Prof M
Steyn, A Prof K Taraporewalla
Sukhpreet Kaur (University of
South Australia) PhD. Improving
drug utilisation in Australian aged
care facilities Supervisor—Dr J
Roberts
Syamhanim Adnan (UQCCR)
PhD. Optimising treatment of complicated infections in critically ill
patients. Supervisor—Dr J Roberts
Xuanhui Li (School of Pharmacy)
MCP. Improving vancomycin dosing in critically ill patients. Supervisor—Dr J Roberts
Julian Williams Andrew Udy
Kellie Stockton
Emergency Physician
PhD Student
Intensivist
PhD Student
Physiotherapist
PhD Student
Infection costs the Australian
healthcare system millions of
dollars every year and imposes a significant burden of
illness on the Australian community. Serious infections can
cause tragedy at a much more
personal level, with lethal outcomes possible even in young
previously healthy individuals.
Despite the significant consequences of these illnesses,
we have very limited information about the best way to
identify and treat infection in
Australian ED.
My research interests are in
critical care pharmacology
and sepsis, specifically the
prescription and pharmacokinetics of antibiotics in the
critically unwell. Current evidence stresses the importance of administering broad
spectrum antibiotics as early
as possible in the treatment of
patients with severe infection.
However, administering the
correct dose is influenced by
a variety of factors, most important of which is the underlying disease process and
other therapies provided.
Systemic Lupus Erythematosus
(SLE) is an episodic, multisystem autoimmune disease with
complex pathogenesis and no
known cure. Patients with SLE
have reduced exercise capacity, reduced strength, reduced
quality of life and elevated levels of fatigue. More than 50% of
these patients describe fatigue
as the most disabling disease
symptom. In addition more than
80% of patients report that fatigue is not adequately addressed in their management
plan. The overall aim of the
research included in my thesis
is to investigate gaps in knowledge of mechanisms relating to
fatigue in SLE. Aims are to:
Systematically review evidence
regarding the effect of vitamin D
supplementation on muscle
strength.
Evaluate the reliability of assessing muscle strength and
function in SLE.
Explore the relationship between muscle strength, vitamin
D status and fatigue in women
with SLE.
Investigate myocardial abnormalities in SLE patients without
clinical evidence of myocarditis
and explore the relationship
between myocardial abnormalities, fatigue and muscle
strength.
Mechanisms related to cause of
fatigue in SLE are poorly understood. An improved knowledge
of fatigue will assist with devising and evaluating more appropriate management strategies.
I am completing a PhD thesis
focusing on patients who present to the ED with community
acquired infection. This research aims to identify the
factors that are apparent early
during the course of infection
that may predict a poor outcome. In addition, I also aim
to improve the immediate
treatment of sepsis syndromes by determining and
optimising various aspects of
care, including antibiotic administration and fluid resuscitation. This ground breaking
body of research is likely to
have a significant impact on
the way that sepsis is identified and managed in the
emergency setting in Australia.
My research focuses on the
renal elimination of antibiotics
and how this is altered by the
administration of vasoactive
medications and fluids in the
critically ill. Augmented renal
clearance (ARC) of antibiotics
is likely to be common in this
setting, leading to subtherapeutic drug levels and
even treatment failure. With an
improved understanding of this
process, optimised dosing regimes can be developed and
implemented, leading to better
patient outcomes.
24
Geetha Kayambu
James Walsh
Ruqaiya Al Balushi
Physiotherapist
PhD Student
Physiotherapist
PhD Student
Dietitian
PhD Student
My thesis incorporates the i-PERFORM
Trial, a randomised clinical trial where
mobilisation of the critically ill is achieved
and the physiological and functional outcomes following early rehabilitation in
sepsis is determined.
Pulmonary rehabilitation has emerged
as recommended standard care for people with Chronic Obstructive Pulmonary
Disease (COPD). However access to
these programs is limited with the demand exceeding the available resources. The aims of my PhD are to
identify the predictive factors for success in pulmonary rehabilitation in terms
of improved health related quality of life
or exercise capacity. The results from
my first study have identified that higher
Taunton Respiratory Questionnaire
scores predicted responders in pulmonary rehabilitation. My current study will
use measures of: expiratory flow limitation, serum inflammatory markers, muscle strength, physical activity
levels, quality of life and self-efficacy
measures in conjunction with the Taunton Respiratory Questionnaire to improve the predictive ability of these findings.
My study investigates the effect of intravenous (iv) Glutamine (Gln) supplementation in trauma patients receiving enteral nutrition. Gln has been traditionally
considered the most abundant nonessential free amino acid in the body
and is deemed to be ―conditionally indispensible‖ in trauma, where depletion in
plasma and tissues is associated with
increased rates of infection.
Early rehabilitation in critical illness has
remained a contentious area of interest
despite growing evidence of delayed
physical functional recovery and poor
quality of life following discharge from
ICU. Patients with sepsis syndromes can
have worse outcomes both for survival
and physical function. The ‗i-PERFORM
Trial‘ will investigate if early targeted
rehabilitation is both safe and effective in
patients with sepsis syndromes admitted
to ICU. This single-centre blinded randomized controlled trial will be conducted
in RBWH ICU. Participants will include
those ≥18 years, mechanically ventilated
for ≥48 hours and diagnosed with a sepsis syndrome. Patients will be randomised to an intervention arm which will
undergo an early targeted rehabilitation
program according to the level of
arousal, strength and cardiovascular
stability. The control group will receive
normal care. The primary outcome
measures will be physical function tests
and anxiety components on discharge
from ICU. Health related quality of life
will be measured at six months post discharge. Secondary measures will include
inflammatory biomarkers, peripheral
blood mitochondrial DNA content and
lactate, fat free muscle mass, tissue oxygenation and microcirculatory parameters. This trial will determine whether
early rehabilitation for patients with sepsis is effective at improving patient outcomes.
In the past, many trials have reported
beneficial effects of Gln supplementation in critically ill patients and currently,
it is the standard of care when parenteral nutrition is given. However, Gln
supplementation in patients on enteral
nutrition is still controversial and more
trials are needed to confirm its beneficial effects in this group. To ensure we
reach our high dose target and to avoid
the possibility of altered gut absorption
capacity, we decided to supplement
Gln via the iv route. To our knowledge,
no study has looked at the effect of iv
Gln in trauma patients receiving standard enteral nutrition on outcomes such
as infectious morbidity.
My study will determine if high dose iv
Gln dipeptide (alanyl-glutamine) is associated with improved clinical outcomes
ie: reduction in infectious morbidity in
trauma patients receiving enteral nutrition.
25
Bernice Bissett
Michelle Spermon
Physiotherapist
PhD Student
Occupational Therapist
MSc Student
My thesis project will investigate Inspiratory Muscle Training (IMT) for ventilated patients.
My study is a novel research project
investigating how donor site epithelisation and scar maturation times following
split skin grafting in burns patients can
be improved using compression therapy.
Patients requiring mechanical ventilation suffer residual inspiratory muscle
weakness following weaning from ventilation. This weakness is correlated
with the duration of ventilation and
may also contribute to difficulty in
weaning from mechanical ventilation.
Specific training of the inspiratory muscles using a threshold device to provide incremental training pressures in
a high-intensity interval-based training
program may hasten weaning and/or
ameliorate some of the residual weakness suffered by patients who have
become ventilator -dependent.
I will be conducting 2 concurrent randomised controlled trials, over 3 years,
to investigate whether IMT facilitates
weaning, reduces post-weaning weakness, enhances quality of life and improves functional measures for patients who have been ventilatordependent for 7 days or more. As a
substudy I will also be investigating
whether IMT has any inflammatory
effects (as measured by urine cortisol)
and may also investigate the relationship between diaphragm thickness
and IMT over a long time period for a
chronically ventilator-dependent
patient.
It is anticipated this research may promote a cost effective intervention
(elasticised bike pants which applies
gentle pressure to the thigh) to accelerate healing and reduce scar formation
for patients with donor sites.
The research aims to improve the quality
and efficiency of current Occupational
Therapy practice for scar management
through evidence based practice. It will
provide valuable information for the future of burns scar management in the
face of a currently expanding treatment
budget and may improve the postoperative management of donor sites.
The study is being conducted in the Professor Pegg Adult Burns Unit and the
Specialist Outpatient Service at RBWH.
I have just obtained ethics approval
and am due to commence subject
recruitment and data collection in
January 2011.
26
Bhavik Patel
Tony Mallett
Surgical Registrar
MPhil Student
MBBS Honours Student
My ten year retrospective study will investigate blood stream infections in
burns patients. The Burns Unit, receives
approx 300 patients with serious burn
injuries every year with a mortality rate
of less than 2%. The most significant
risk factor for mortality is the development of blood stream infections. This
study will evaluate the potential factors
that are predictive of blood stream infections and provide important information
for clinicians in relation to future management of infection in burns patients.
The one year prospective study will
investigate the Therapeutic Drug Monitoring (TDM) of β-lactam antibiotics in
burns patients. Recent data from the
BTCCRC has shown that β-lactams are
inappropriately dosed in 70% of ICU
patients, including burns patients. Dose
adjustment after TDM represents an
appropriate method of dose optimisation
for these patients although no data has
ever been produced in this group. Given
that burn patients have profoundly altered host defences which predisposes
them to an increased incidence of infection, improving antibiotic dosing is essential. This study seeks to measure the
appropriateness of empiric dosing, dose
adjustment based on TDM and potential
for improved resolution of infection in
burns patients.
Burns patients have profoundly altered
host defences which increases the impact of infection in this group. Bloodstream infections (BSI) in particular are
a major cause of morbidity and mortality
in these patients. The choice of initial
antibiotics is critical in the management
of BSI because inadequate empirical
antibiotic treatment significantly increases mortality. Improved prediction
of the likely organisms and their susceptibilities would improve empirical antibiotic treatment and therefore survival.
Specific aims are to:
Identify the organisms causing BSI.
Identify any changes in the types of organisms causing BSIs with increasing
length of stay.
Identify the risk factors for mortality in
patients with BSI.
A retrospective study was conducted
using patient charts and databases
maintained by the Stuart Pegg Burns
Unit at the RBWH. Data was collected
from 99 patients who experienced BSI
during the 10 year study period from
January 1999 to December 2008.
Staphylococcal spp were most common
(34%) followed by Pseudomonas aeruginosa (30%) and Acinetobacter baumannii (10%). Gram positive organisms
were most common in the first week
post admission (78%) falling in week two
(50%) and week three (30%). Inhalation
injury was the sole independent risk
factor for mortality.
27
Smriti Tandon
Medical Student 4th Year
Australia's vast size and relatively small
population provides a challenge for competent and timely management of surgical emergencies and trauma.
Over the last 10-20 years there has
been an increasing trend towards specialization and subspecialization in surgery and a move away from broadly
trained general surgeons and general
practitioners. Despite the RFDS, and
increasing use of telemedicine and retrieval services there are still situations
anecdotally reported in which procedures (e.g. burr holes following head
injury, escharotomies for burns and fasciotomies for compartment syndrome)
performed in the rural hospital may have
improved the consequent outcome of
the patient.
We are investigating records of interhospital transfers to RBWH (2004-2008) to
identify whether a delay in surgical intervention in the rural setting may have
affected patient outcome. This will have
implications for the training of future
surgical trainees.
I am from the University of Melbourne
undertaking this project under the guidance of Dr Cliff Pollard and Dr Jennifer
Paratz, along with Patrick Pearce (4th
year medical student, UQ).
28
Marta Ulldemolins
Visiting Pharmacist
I am a recent graduate in Pharmacy
from Barcelona and am a MPhil candidate. Currently I am working in critical care research in Tarragona,
Spain and have come to Brisbane to
undertake a one year training course
in
pharmacokinetics/
pharmacodynamics (PK/PD) with
Prof. Jeffrey Lipman and Dr. Jason
Roberts.
My main interest of research is the
alterations in antibiotic PK/PD that
occur in critically ill patients. Dr Roberts is supervising my project which
endeavours to study whether low
albumin concentration levels
(hypoalbuminaemia) observed in
critically ill patients affect the PK of
highly protein-bound antibiotics. With
this data, we will evaluate if standard
dose and dosing regimens are appropriate for the treatment of severe
infections in critically ill patients with
hypoalbuminaemia and develop optimal dosing recommendations to better treat these patients.
My time with the Burns Trauma and
Critical Care Research Centre team
has been very fulfilling and valuable.
This hard-working and multidisciplinary team guided me throughout the
full research pathway, from sample
collection to data analysis, which has
assisted me greatly in my MPhil.
Journal Articles
Martin JH, Norris R, Barras M, Roberts JA, Morris R,
Doogue M, Jones GRD. Therapeutic Monitoring of
Vancomycin in Adult Patients: A Consensus Review of the
American Society of Health-System Pharmacists, the
Infectious Diseases Society of America, and the Society of
Infectious Diseases Pharmacists. Clin Biochem Rev 2010;
31: 21-24.
Greenland KB, Edwards MJ, Hutton NJ. External auditory
meatus-sternal notch relationship in adults in the sniffing
position: a magnetic resonance imaging study. British
Journal of Anaesthesia 2010;104: 268-269
Greenland KB. Airway assessment based on a three column
model of direct laryngoscopy. Anaest Intens Care 2010;38
(1): 14-19.
Roberts JA, Hope WH, Lipman J. Therapeutic drug
monitoring of β-lactams for critically ill patients Unwarranted or essential? Int J Antimicrob Agents 2010;35
(5): 419-420
Ulldemolins M, Roberts JA, Lipman J. Optimizing antibiotic
use in the intensive care unit. Clin Pulm Med 2010;17(4) 162
–169.
Udy AA, Putt M, Shanmugathasan S, Roberts JA, Lipman J.
Augmented Renal Clearance (ARC) in the Intensive Care
Unit - An illustrative Case Series. Int J Antimicrob Agents
2010; Jun 35(6): 606-608.
Roberts JA, Ulldemolins M, Lipman J. Meropenem: Focus
on its use in Serious Bacterial Infections, Clin Med Rev Ther
2010; 2:1-14.
Dulhunty JM, Webb SAR, Paterson DL, Bellomo R, Myburgh
J, Roberts JA, Lipman J.A survey of antibiotic prescribing
practices in Australian and New Zealand intensive care
units. Crit Care Resusc 2010;12: 162-170.
Ulldemolins M, Roberts JA, Wallis SC, Rello J, Lipman J.
Flucloxacillin dosing in critically ill patients with
hypoalbuminaemia - special emphasis on unbound
pharmacokinetics. J Antimicrob Chemother 2010;65( 8):
1771–1778.
Cowlishaw PJ, Belavy D. Is cell salvage safe in transnasal
surgery? Anaesthesia. 2010; 65:207. Letter
Ulldemolins M, Roberts JA, Lipman J, Rello J. Antibiotic
dosing in multiple organ dysfunction syndrome. Crit Care
Res Pract. 2010; in press
Bilgrami I, Roberts JA, Wallis SC, Thomas J, Davis J,
Fowler S, Goldrick PB, Lipman J. Meropenem dosing in
29
critically ill patients with sepsis receiving high volume
continuous veno-venous hemofiltration. Antimicrob Agents
Chemother, 2010; 54(7): 2974–2978.
Tan T, Chang L, Woodward A, McWhinney B, Galligan J,
Macdonald G, Cohen J,
Venkatesh B. Characterising
adrenal function using directly measured plasma free
cortisol in stable severe liver disease. J Hepatol. 2010; 53
(5):841-848
Varghese JM, Roberts JA, Lipman J. Pharmacokinetics and
pharmacodynamics in critically ill patients. Curr Opin
Anesthesiol 2010; 23: (4): 472-478.
Bell A, Lipp T, Greenslade J, Chu K, Rothwell S, Duncan A.
A Randomized Controlled Trial Comparing PatientControlled and Physician-Controlled Sedation in the
Emergency Department. Annals of Emergency Medicine.
2010;56(5):502-508
Higgins N, Taraporewalla K, Steyn M, Brijball R, Watson M.
Workforce education issues for international medical
graduate specialists in anaesthesia. Australian Health
Review, 2010; 34: 246–251.
Zugai BM, Eley V, Mallitt KA, Greenland KB. Practice
patterns for predicted difficult airway management and
access to airway equipment by anaesthetists in
Queensland, Australia. Anaesth Intensive Care. 2010
Jan;38(1):27-32.
Martin JH , Fay MF, Udy A, Roberts JA, Kirkpatrick CMJ,
Ungerer J, Lipman J. Pitfalls of using estimations of
glomerular filtration rate in an intensive care population
Intern Med J. 2010; Jan 4,
doi: 10.1111/j.14455994.2010.02160.
Playford EG, Lipman J, Sorrell TC. Management of invasive
candidiasis in the intensive care unit. Drugs. 2010 May 7;70
(7):823-839.
Roberts JA, Kirkpatrick CM, Roberts MS, Dalley AJ, Lipman
J. First-dose and steady-state population pharmacokinetics
and pharmacodynamics of piperacillin by continuous or
intermittent dosing in critically ill patients with sepsis. Int J
Antimicrob Agents. 2010 Feb;35(2):156-163.
Udy AA, Roberts JA, Boots RJ, Paterson DL, Lipman J.
Augmented renal clearance: implications for antibacterial
dosing in the critically ill. Clin Pharmacokinet. 2010; 49(1):116.
Doidge M, Allworth AM, Woods M, Marshall P, Terry M,
O'Brien K, Goh HM, George N, Nimmo GR, Schembri MA,
Lipman J, Paterson DL. Control of an outbreak of
carbapenem-resistant Acinetobacter baumannii in Australia
after introduction of environmental cleaning with a
commercial oxidizing disinfectant. Infect Control Hosp
Epidemiol. 2010 Apr;31(4):418-420.
Frohmader TJ, Chaboyer WP, Robertson IK, Gowardman J.
Decrease in frequency of liquid stool in enterally fed critically
ill patients given the multispecies probiotic VSL#3: A pilot
trial. Am J Crit Care. 2010 May;19(3):e1-11.
Cohen J, Venkatesh B. Relative adrenal insufficiency in the
intensive care population; background and critical appraisal
of the evidence. Anaesth Intens Care 2010; 38(3): 425-436.
Corona A, Bertolini G, Lipman J, Wilson PA, Singer M.
Antibiotics use and impact on bacteraemic critical illness
outcome: the BActeraemia Study in Intensive Care (BASIC)
J Antimicrob Chemother 2010 Jun;65(6):1276-1285.
Patil V, Dulhunty JM, Udy AA, Thomas P, Kucharski G,
Lipman J. Do burns patients cost more? The intensive care
unit costs of burn patient compared with controls matched for
length of stay and acuity. J Burn Care Res. 2010; 31(4):598602.
Winzer BM, Paratz JD, Reeves MM, Whiteman DC. Exercise
and the Prevention of Oesophageal Cancer (EPOC) Study
Protocol: A Randomized Controlled Trial of Exercise Versus
Stretching in Males with Barrett‘s Oesophagus. BMC Cancer.
2010; 10: 292.
McWhinney BC, Wallis SC, Hillister T, Roberts JA, Lipman J,
Ungerer JPJ. Analysis of twelve β-lactam antibiotics in
human plasma by HPLC with ultraviolet detection. J
Chromatograph B 2010; 878 (22): 2039-2043.
Venkatesh B, Morgan J, Cohen J Interstitium: The next
diagnostic and therapeutic platform in critical illness Crit Care
Med 2010; 38 (10) [Suppl.]:S630 –S636
Gowardman JR, Lipman J, Rickard CM. Assessment of
peripheral arterial catheters as a source of sepsis in the
critically ill: a narrative review. J Hosp Infect. 2010 May;75
(1):12-8. REVIEW
Roberts JA, Field J, Visser A, Whitbread R, Tallot M, Lipman
J, Kirkpatrick CMJ. Using population pharmacokinetics to
dose gentamicin during extended-daily diafiltration in critically
ill patients with acute kidney injury. Antimicrob Agents
Chemother 2010; 54(9): 3635–3640.
Belavy D. Regional Anesthesia Needles Can
Introduce Ultrasound Gel into Tissues. Anaesthesia and
Analgesia 2010 ;111(3):811-2.
Dhanani JA, Roberts JA, Chew M., Lipman J, Boots RJ,
Paterson DL, Fraser J. Antimicrobial Chemotherapy and
Lung Microdialysis - A Review. Int J Antimicrob Agents 2010;
36(6);491-500.
Roberts JA, Ulldemolins M, Roberts MS, McWhinney BC,
Ungerer JPJ, Paterson DL, Lipman J. Therapeutic Drug
Monitoring of β-lactams in Critically Ill Patients: Proof of
concept. Int J Antimicrob Agents 2010; 36(4): 332-339.
Hayashi Y, Roberts JA, Paterson DL, Lipman J.
Pharmacokinetic evaluation of piperacillin plus tazobactam.
Exp Opin Drug Metab Toxicol 2010; 6 (8): 1017-31.
Roberts JA, Boots RJ, Lipman J. Optimal Antibiotic Therapy
in the Management of the lung of the critically ill. Curr Rev
Respir Med 2010; 6:253-63.
Makris N, Dulhunty JM, Paratz JD, Bandeshe H, Gowardman
JR. Unplanned early readmission to the intensive care unit: a
case-control study of patient, intensive care and ward-related
factors. Anaesth Intensive Care. 2010;38(4):723-31.
Playford EG, Lipman J, Sorrell TC. Prophylaxis, empirical
and preemptive treatment of invasive candidiasis. Curr Opin
Crit Care. 2010;16(5):470-4.
Bellapart J, Geng S, Dunster K, Timms D, Barnett AG, Boots
R, Fraser JF. Intraaortic Balloon Pump Counterpulsation and
Cerebral Autoregulation: an observational study. BMC
Anesthesiol. 2010;10:3.
Nunnink L, Venkatesh B, Krishnans A, Vidhani K, Udy A. A
prospective comparison between written examination and
either simulation-based or oral viva examination of intensive
care trainees' procedural skills. Anaesth Intensive Care.
2010;38(5):876-82.
Cohen J, Venkatesh B. When an effect is unclear,
questioning its proposed mechanism is appropriate. Crit Care
Resusc. 2010;12(1):68.
Holley A, Udy A, Paratz J, Lipman J The microcirculation,
regional blood flow and tissue oxygenation: will new
technologies drive new resuscitation goals? Anaesth
Intensive Care 2010; 37: 700-702
Douglas AE, Holley A, Udy A, Lipman J, Gomersall CD,
Joynt GM, Freebairn RC, Boots RJ. Can learning to sustain
life be BASIC? Teaching for the initial management of the
critically ill in Australia and New Zealand. Anaesth Intensive
Care. 2010 Nov;38(6):1043-51.
Brown AF, Cullen L, Than M. Future developments in chest
pain diagnosis and management. Med Clin North Am. 2010
Mar;94(2):375-400
30
Pang G, Edwards MJ, Greenland KB. Vocal cords-carina
distance in anaesthetised Caucasian adults and its clinical
implications for tracheal intubation. Anaesth Intensive Care
2010; 38: 1029-1033
Udy A, Boots R, Senthuran S, Stuart J, Deans R, LassigSmith M. Augmented Creatinine Clearance in Traumatic
Brain Injury. Anaesth Analg. 2010: 111 (6): 1505-1510.
Greenland KB, Edwards MJ, Hutton NJ, Challis VJ, Irwin
MG, Sleigh JW. Changes in airway configuration with
different head and neck positions using magnetic resonance
imaging of normal airways: a new concept with possible
clinical applications. Br J Anaesth. 2010 Nov;105(5):683-90.
Choi G, Gomersall CD, Tian Q, Joynt GM, Li AMMY, Lipman
J. Principles of Antibacterial Dosing in Continuous Renal
Replacement Therapy. Blood Purif 2010; 30:195–212.
Brown AFT. Emergency Medicine Australasia‘s first Impact
Factor. Emerg Med Australas 2010;22:361-362.
Brown AFT, Cullen L, Than M. Future developments in
chest pain diagnosis and management. Med Clin N Am
2010;94:375-400.
Cullen L, Than M, Brown AFT et al. Comprehensive
standardised data definitions for acute coronary syndrome
research in emergency departments in Australasia. Emerg
Med Australas 2010;22:35-55.
Miró O, Burillo-Putze G, Plunkett PK, Brown AFT. Female
representation on emergency medicine editorial teams. Eur
J Emerg Med 2010;17:84-88.
Belavy D. Regional Anesthesia Needles Can Introduce
Ultrasound Gel into Tissues. Anesth Analg 2010;111:811–
812.
Boots RJ, Dulhunty JM, Paratz J, Lipman J. Respiratory
burns: a clinical review. Current Respiratory Medicine
Reviews 2010:6;285-291.
Hanekom S, Berney S, Morrow B, Ntoumenopoulos G,
Paratz J, Patman S, Louw Q. The validation of a clinical
algorithm for the prevention and management of pulmonary
dysfunction in intubated adults – a synthesis of evidence
and expert opinion. J Evaluat Clin Pract 2010;
Prentice CE, Paratz JD, Bersten AD. Differences in the
degree of respiratory and peripheral muscle impairment are
evident on clinical, electrophysiological and biopsy testing in
critically ill adults: a qualitative systematic review. Crit Care
Resusc 2010; 12(2): 111–120
Roberts JA, Ulldemolins M, Roberts MS, McWhinney B,
Ungerer J, Paterson DL, Lipman J. The Utility of Beta-
31
lactam Therapeutic Monitoring in Critically Ill Patients: Proof
of concept. Int J Antimicrob Agents 2010; 36(4): 332-9.
Chang A, Palmer K, McNaught J, Thomas P. Inspiratory
flow rate, not type of incentive spirometry device influences
chest wall motion in healthy individuals. Physiotherapy
Theory and Practice, 2010; 26(6):385-392.
Boots RJ, Udy A, Holley AD, Lipman J. Preventative
Strategies for Ventilator Associated Pneumonia. Curr Resp
Med Rev. 2010;6(4):238-252.
Published Proceedings
Roberts, DM, Roberts, MS, Liu, X, Roberts, JA, Lipman, J
and Bellomo, R (2010). Clearance of antibiotics by high and
low intensity continuous renal replacement therapy in
critically ill patients. In 23rd Annual Meeting of the European
-Society-of-Intensive-Care-Medicine, OCT 09-13, 2010,
(S200-S200), Barcelona SPAIN.
De Waele, J, Moreno, R, Anzueto , A, Lipman, J, Rello, J,
Sakr, Y and Vincent, JL (2010). Infections and use of
antibiotics in patients admitted for severe acute pancreatitis:
data from the epic2 study. In 23rd Annual Meeting of the
European-Society-of-Intensive-Care-Medicine, OCT 09-13,
2010, (S250-S250), Barcelona SPAIN.
Putt, MT, Roberts, JA, Udy, AA, Martin, JH, Jarrett, P,
Salmon, N and Lipman, J (2010). Assessment of adequacy
of loading dose of phenytoin (ptn) in adult intensive care
patients using population pharmacokinetics. In 23rd Annual
Meeting of the European-Society-of-Intensive-CareMedicine, OCT 09-13, 2010, (S413-S413), Barcelona
SPAIN.
Walsh J, Paratz J, McKeough Z, Seale H & Morris N., The
Taunton Respiratory Questionnaire may be useful in
Identifying Responders to Pulmonary Rehabilitation.
Respirology, 2010;15(1):A40
Walsh J, Paratz J, Chang A, McKeough Z, Seale H & Morris
N., Identifying Responders to Pulmonary Rehabilitation, The
e-AJP, 2009; 55(4), S25.
Book Chapters
Ulldemolins M, Roberts JA, Rello J. Drug distribution – is it
a more important determinant of drug dosing than clearance?
In: Vincent JL ed. In Yearbook of Intensive Care and Emergency Medicine. in press
Ulldemolins M, Roberts JA, Varghese J, Lipman J. Antibiotic
Dosing in Critically Ill Patients. In: Nayar V et al ed. Critical
Care Update 2009, Jaypee Brothers Medical Publishers Ltd,
Delhi, 2010.
Holley A, Udy A, Boots R. Fluids. In Basic Assessment and
Support in Intensive Care Textbook. in press
Boots R, Holley A, Udy A. Medical Emergency Response
and Crisis Resource Management. In Basic Assessment and
Support in Intensive Care Textbook. in press
Brown AFT, Brazil V. ―Constipation‖. Chapter 14. in “An Introduction to Clinical Emergency Medicine”, 2nd edition, eds Mahadevan SV, Carmel GM. Cambridge University Press, Cambridge. in press
Brown AFT. ―Anaphylaxis‖. Chapter in ―Oxford Textbook of
Medicine‖ 5th Edition, eds Warrell DA, Cox TM, Firth JD, Benz
EJ. Oxford University Press, Oxford. May 2010.
Forewords
Brown AFT. Foreword to: Murray L, Daly F, Little M, Cadogan
M. Toxicology Handbook, 2nd edition. Elsevier, Sydney.
2010.
Brown AFT. Foreword to: Wilkes G, Peirce B, Foot C, Ting J.
Examination Emergency Medicine. Churchill Livingstone,
Sydney, 2010.
Boots R, Udy A, Roberts J, Lipman J. Effective Use of Antibiotics in Pulmonary Infections. in press
Udy A, Roberts J, Lipman J. Augmented Renal Clearance
(ARC) - unravelling the mystery of elevated antibiotic clearance. In: Vincent JL ed. In Yearbook of Intensive Care and
Emergency Medicine. Springer, Brussels, 2010, pp495-506.
Venkatesh B, Cohen J. Adrenal Insufficiency. In Surgical
Intensive Care Medicine. 2nd Edition. 2010, pp399-407.
Ulldemolins M, Roberts JA, Rello J. Drug distribution – is it
a more important determinant of drug dosing
than clearance? In: Vincent JL ed. In Yearbook of Intensive
Care and Emergency Medicine. Springer, Brussels. in press
Roberts JA, Lipman J. ―Dose adjustment and pharmacokinetics of antibiotics in severe sepsis and septic shock‖.
Rello, Kollef, Díaz, Rodríguez (Eds.) In Infectious Diseases
in Critical Care, 2nd ed. in press
Ulldemolins M, Roberts J. How do I adjust antimicrobial daily
dosage in Patients with MODS? A pharmacist contribution.
In: Rello, Lipman, Lisbon ed. Sepsis Management: PIRO
and MODS, Springer, Germany. in press
Paterson DL, Ulldemolins M Cephadroxil, Cephaloridine,
Cephacetrile, Cephapirin, Cephradine and Other Rarely
Used first generation Cephalosporins. The Use of Antibiotics. The American Society of Microbiology Publishers. in
press
Brown AFT. Senior Associate Editor for Textbook of Asian
Emergency Medicine, eds David S, Brown AFT, Banerjee A,
Anantharaman A, Nelson B. This is the first ever multi-author
textbook of emergency medicine developed for India and environs. Wolters Kluwer (Health). in press
32
Teaching
Jeffrey Lipman
 Specialties II, Critical Care Course, MBBS Year 4,
 Sepsis Symposium, MBBS Year 2
 Basic Assessment & Support in Intensive Care (BASIC)
course — intensive care trainees, senior nurses, medical
officers
Jenny Paratz
 PHTY 3250, PHTY 2230
 QLD Skills Development Centre—Physiotherapy & Critical Care Management (PACCMan)
Jason Roberts
 Adjunct lecturer, School of Pharmacy, Queensland University of Technology
 Invited lecturer, Monash University, Victorian Pharmacy
College of Practice
Michael Muller
 1st Year MBBS, Burns Lectures
 3rd Year MBBS, Burns Clinic
 2nd Year MBBS, Burns Lectures
 Surgical Registrars
 Intensive Care Paramedics students, Burns Lectures
 Physiotherapy students
Michelle Spermon
 P.A.R.T.Y (Prevent Alcohol and Risk-related Trauma in
Youth) Programme Education sessions.
James Walsh
 UQ physiotherapy courses PHTY 3250 -7825
 Griffith University physiotherapy courses
Bernadette Bissett
 Tutor and guest lecturer, School of Physiotherapy, University of Canberra.
Geetha Kayambu
 School of Physiotherapy, The University of Queensland
 Skills practice: Airway Clearance Techniques Tutorial
 CXR Lecture/Tutorial
 Skills practice: Suction and Manual hyperinflation
Weragoda Abeypala
 Teaching of undergraduates in Anaesthesia in the operating room.
 Module Supervisor for Obstetric Anaesthesia—
Teaching, training and assessment of anaesthetic trainees.
Anthony Holley
 Supervisor for College of Intensive Care Medicine training at The Royal Brisbane & Women‘s Hospital
Anthony Brown
 MB BS Program Yr 4
 CCC DEM students – clinical reasoning teaching
 Spec I – lectures
 Yr 2 – Lectures / CLG teaching on collapse
Andrew Udy
 BASIC Course,
 Early management of severe trauma (EMST) Course,
 Intensive care crisis event management (ICCEM) course
 Brisbane primary anaesthesia and intensivecare refresher course.
 4th Year MBBS
Kellie Stockton
 Arthritis Qld delivering public seminars and health professional education in MT Isa, Cloncurry, Mackay, Gladstone, Cairns and Townsville.
 Sessional lecturer UQ PHTY course.
Keith Greenland
 Fibreoptic workshops and Emergency Surgical Airway
workshops within the Dept of Anaesthesia RBWH.
Paul Gray
 trainees in Pain Medicine and Anaesthesia.
33
Achievements and Awards
Jeffrey Lipman
 Awarded RBWH 2010 Special Research Award
 Eurpoean Society of Intensive Care Medicine ECCRN
Established Investigator Award
Anthony Holley
 Matthew Davey Award 2010. RAN Professional studies
program
 Commanding Officer‘s Commendation 2010. HMAS
MANOORA. Exercise Croix Du Sud. French New Caledonia
Bhavik Patel
 Co-Winner Heat 1,UQ Three minute thesis competition,
Brisbane , Australia.
 Successfully completed Mid Candidature review for the
Masters in Research (MPhil) project with University of
Queensland.
Bernadette Bissett
 Best Paper - Inspiratory muscle training is safe in selected ventilated patients. Australian Physiotherapy Association, ACT Research Symposium Sept
 Canberra Hospital Private Practice Fund Major Grant—
Randomised trials of Inspiratory Muscle Training in Ventilated Patients.
Heather Reynolds
 Winner—best acute and critical care PhD student research oral presentation, Gold Coast Health and Medical
Research Conference (Griffith University), Gold Coast.
 Winner—best poster, Perioperative Nurses Association of
Queensland Annual Conference, Gold Coast.
Michael Muller
 Winner—best paper, 2010 Queensland Statewide
Trauma Symposium, Brisbane.
 Winner—best surgical presentation, RBWH Health Care
Symposium, Brisbane, Queensland.
Andrew Udy
 Free Paper Prize - Augmented Renal Clearance (ARC)
in traumatic brain injury - College of Intensive Care
Medicine, Annual Scientific Meeting
 Best Clinical Science Poster—Augmented renal clearance (ARC) in critically ill patients with SIRS and sepsis:
Are estimates of renal function accurate? - RBWH
Healthcare Symposium
Ruqaiya Al-Balushi
 PhD confirmation November 2010
Brooke Winzer
 Graduate School Research Travel Grant
Jason Roberts
 Awarded the School of Medicine Dean‘s Award for Outstanding Research Higher Degree.
 Finalist, Clinical Pharmacist of the Year Award, SHPA,
November.
Keith Greenland
 completed MD thesis "A Reappraisal of Adult Difficult
Airway Management - Theoretical and Practical Aspects"
Kellie Stockton
 PhD confirmation February 2010
34
Invited Presentations
Jeffrey Lipman
 ANZICS, Hawke‘s Bay, New Zealand Mar
 16th Annual Conference of Indian Society of Critical Care
Medicine, Hydrabad Feb
 30th International Symposium of Intensive Care and
Emergency Medicine, Brussels Mar
 7th Annual Critical Care Symposium – Oldham Hospital,
Manchester Apr
 Southern African Critical Care Society Meeting
Drakensberg South Africa Oct
 23rd Annual European Society of Intensive Care Medicine Meeting Barcelona Oct
 Infection Section Spanish Intensive Care Society, Las
Palmas, Nov
Anthony Brown
 Anaphylaxis Update. 27th Annual Scientific Meeting,
ACEM, Canberra. Nov
 Teaching medical students emergency medicine—Do
we have a common consensus. 27th Annual Scientific
Meeting, ACEM, Canberra. Nov
 How to engage your University in emergency medicine.
27th Annual Scientific Meeting, ACEM, Canberra. Nov
 Medical Emergencies. The College Lecture Series,
FRACP Training Program. Brisbane.
 Current understanding of traumatic shock. 2nd International Symposium on Emergency Medicine (ISEM). Keynote speaker. Kolkata, West Bengal, India. Aug
 Anaphylaxis: An overview. 2nd International ISEM. Keynote speaker. Kolkata, West Bengal, India. Aug
 New diagnostic markers in early sepsis. 2nd ISEM. Keynote speaker. Kolkata, West Bengal, India. August 2010.
 Critical asthma; Diagnosis and management. 2nd ISEM.
Invited Keynote speaker. Kolkata, West Bengal, India.
Aug
 Anaphylaxis gets the adrenaline going. A clinical update.
Christian Medical College (CMC) Hospital. Vellore, Tamil
Nadu, India. Aug
Paul Gray
 Acute Pain - General Principles. Training Program for
the Australian College of Rural and Remote Medicine
Novotel Hotel, Brisbane , May
 Persistent Pain National Professional Development
Workshop on Pain Management Pharmacy Australia
Centre of Excellence Brisbane, Apr
 Phantom Skin Pain– the Neuropathic Pain of Burn Injury. 30th Annual Scientific Meeting of the Australian
Pain Society Gold Coast Convention Centre Gold
Coast, Mar
Andrew Udy
 Antimicrobial Dosing in the Critically Ill - SHPA Continuing Education Session, Oct
35
Anthony Holley
 Critical Care 2010. Continuous Renal Replacement
Therapy and Toxicology, Sept
 ANZICS ASM. The Microcirculation in distress, Oct
 ACEM ASM What‘s new in critical care and Endpoints/
goals in resuscitation, Nov
 2HSB-RBWH Military Trauma Symposium. What‘s new
in trauma critical care, Dec
Jenny Paratz
 Importance of Exercise: from critical care patients to
those at home APA symposium Exercise in Body and
Mind Perth, June
 Proactive rehabilitation of the acute respiratory patient
APA symposium Exercise in Body and Mind Perth, June
Jason Roberts
 Optimizing PK/PD of antibiotics to improve outcomes.
American Thoracic Society International Conference,
New Orleans, USA, May
 Antimicrobial dosing during renal support. College of
Intensive Care Medicine Annual Scientific Meeting, Sydney, June
 Antibiotic therapeutic drug monitoring – The who, the
why and the how. SHPA South Australian/Northern Territory Branch, Autumn Symposium, Adelaide, May
 Antibiotics pharmacokinetics in ICU: where are we now?
And where are we headed? Antibiotic Symposium, The
Alfred Hospital, Melbourne, May
 Dosing antibiotics in the obese patient. Australian Society for Antimicrobials – Annual Scientific Meeting, Sydney, Australia, Feb
Marta Ulldemolins
 Ulldemolins M. How to adjust antibiotic dosing in MODSA pharmacist contribution. Sepsis 2010: Clinical Failure.
Tarragona, Spain, June
Robert Boots
 High frequency oscillation. Australia New Zealand Intensive Care Conference, Melbourne. Plenary session.
Keith Greenland
 Australian Society of Anaesthetists National Scientific
Meeting, Melbourne
Presentations
Jenny Paratz
 Paratz JD, Paratz ED, Muller MJ, O‘Donoghue S,
Holley A, Boots RJ. What is the optimal method to
resuscitate burns patients? A systematic review investigating fluid composition and endpoints of resuscitation. ANZBA, Darwin
 Plaza A, Stockton K, Muller M, Hoskin B, Paratz J
Exercise programmes are effective and safe in a
burns population: a controlled trial ANZBA, Darwin
 Stockton K1 Morrison M, Davis M, Brown M, Muller
M, Paratz J. Physiological responses to maximal exercise testing and modified shuttle walk test in adults
post thermal injury ANZBA, Darwin
 Muller M, Dulhunty J, Paratz J, Harrison J, Redman
B, Rudd M Fighting fuel and flame: effectiveness of a
burn prevention campaign ANZBA, Darwin
 Paratz JD, Paratz ED, Muller MJ, O‘Donoghue S,
Holley A, Boots RJ. What is the optimal method to
resuscitate burns patients? A systematic review investigating fluid composition and endpoints of resuscitation. ANZICS, Melbourne (poster).
Heather Reynolds
 Management of peripheral arterial catheters in Australian operating theatres. H. Reynolds, J. Dulhunty,
M. Tower, K. Taraporewalla, C. Rickard. RBWH Symposium (Poster)
 Management of peripheral arterial catheters in Australian operating theatres. Reynolds H, Dulhunty J,
Tower M, Taraporewalla K and Rickard C. RBWH
and perioperative nurses association of Qld Conference
James Walsh
 The Thoracic Society of Australia and New Zealand
Annual Scientific Meeting. Walsh J, Paratz J, McKeough Z, Seale H & Morris N, The Taunton Respiratory Questionnaire may be useful in Identifying Responders to Pulmonary Rehabilitation.
 Cardiac Society of Australia and New Zealand Annual Meeting. RJ Davis, K Hall, JR Walsh, HE Seale,
JE Harris, DJ Radford, FD Kermeen. Severe Hypoxia
in Eisenmenger Syndrome Does Not Preclude Safe
Performance of the Six Minute Walk Test
 The International Society of Heart and Lung Transplantation Annual Scientific Meeting. Walsh J, Chambers D, Davis R, Seale H, Morris N, Kermeen F, Hopkins P, Ambulatory Muscle Strength Recovery is Delayed when compared to Lung Function and Six Minute Walk Distance after Lung Transplantation (oral)
 The Thoracic Society of Australia and New Zealand
Annual Scientific Meeting. Davis R, Hall K, Walsh J,
Seale H, Harris J, Radford D, Kermeen F, Severe
Hypoxia in Eisenmenger Syndrome Does Not Preclude Safe Performance of the Six Minute Walk Test.
 The Thoracic Society of Australia and New Zealand An-
nual Scientific Meeting. Morris N, Seale H, Sabapathy N
& Walsh J, Pulmonary Rehabilitation Fails to Increase
the Level of Physical Activity in COPD.
 International Conference on Pulmonary Circulation, Prague RJ Davis, K Hall, JR Walsh, HE Seale, JE Harris,
DJ Radford, FD Kermeen, Severe Hypoxia in Eisenmenger Syndrome Does Not Preclude Safe Performance
of the Six Minute Walk Test (poster).
 The International Society of Heart and Lung Transplantation Annual Scientific Meeting, Chicago. Davis R, Hall K,
Walsh J, Seale H, Harris J, Radford D, Kermeen F., Severe Hypoxia in Eisenmenger Syndrome Does Not Preclude Safe Performance of the Six Minute Walk Test
(poster).
Andrew Udy
 Augmented renal clearance (ARC) in critically ill patients
with SIRS and sepsis: Are estimates of renal function
accurate? RBWH Healthcare Symposium
 Timing of Blood Culture Collection in Patients with Acute
Kidney Injury receiving Renal Replacement Therapy.
Annual Scientific Meeting, College of Intensive Care
Medicine, June
 Augmented Renal Clearance (ARC) in Traumatic Brain
Injury. Annual Scientific Meeting, College of Intensive
Care Medicine, June
 Assessment of Adequacy of Phenytoin Loading in Adult
Intensive Care Patients. RBWH Healthcare Symposium
(poster)
 Augmented renal clearance (ARC) in critically ill patients
with SIRS and sepsis: Are estimates of renal function
accurate? RBWH Healthcare Symposium (poster)
 Timing of Blood Culture Collection in Patients with Acute
Kidney Injury receiving Renal Replacement Therapy.
RBWH Healthcare Symposium (poster)
 Timing of Blood Culture Collection in Patients with Acute
Kidney Injury receiving Renal Replacement Therapy.
Annual Scientific Meeting, College of Intensive Care
Medicine, June (poster)
36
 Augmented Renal Clearance (ARC) in Traumatic Brain
Injury. Annual Scientific Meeting, College of Intensive
Care Medicine, Jun (poster)
 Augmented Renal Clearance (ARC) in Traumatic Brain
Injury. 30th International Symposium on Intensive Care
and Emergency Medicine, Mar (poster)
Bhavik Patel
 Characteristics of Blood stream infections in burn injury
patients: A ten year retrospective study at RBWH. Patel
B, Mallett A, Roberts J, Paratz J, Lipman J, Rudd M ,
Muller M and Paterson D. Annual Scientific Conference
of ANZBA, Darwin Oct (poster)
 Characteristics of Blood stream infections in burn injury
patients: A ten year retrospective study at RBWH. Patel
B, Mallett A, Roberts J, Paratz J, Lipman J, Rudd M ,
Muller M and Paterson D. RBWH Health Care Symposium, Brisbane (poster).
 Therapeutic drug monitoring of b-lactam antibiotics in
burns patients –One year prospective study. Patel B,
See N, Roberts J, Paratz J, Lipman J, Rudd M , Muller
M and Paterson D. RBWH Health Care Symposium,
Brisbane (poster).
Anthony Holley
 The Microcirculation in inhalational Injury- an ovine
model. Australian Military Medicine Association, Oct
Jason Roberts
 Roberts JA, Douglas A, Jarrett P, Lassig-Smith M, Stuart J, Wallis SC, Medley G, Jenkins J, Lipman J.
Plasma and tissue concentrations of cefazolin during
abdominal aortic aneurysm repair surgery – are standard doses sufficient? SHPA National Conference, Melbourne, Nov.
 Varghese JM, Ranganathan D, Lipman J, Roberts JA.
Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD Study).
SHPA National Conference, Melbourne, Nov.
 Varghese JM, McWhinney B, Ungerer J, Lipman J,
Roberts JA. Subtherapeutic trough β-lactam levels in
critically ill patients are associated with high creatinine
clearance. SHPA National Conference, Melbourne,
Nov.
 Li J, Udy AA, Kirkpatrick CMJ, Roberts JA. An educational intervention to improve vancomycin initial dosing
in critically ill patients. SHPA National Conference, Melbourne, Nov.
 Roberts JA, Roberts DM, Roberts MS, Liu X, Lipman J,
Bellomo R. Clearance of antibiotic by high and low intensity continuous renal replacement therapy in critically
ill patients. European Society of Intensive Care Medicine Annual Congress, Barcelona, Oct.
 Roberts JA, Putt MT, Udy AA, Jarrett P, Martin J,
Salmon N, Lipman J. Assessment of adequacy of
phenytoin loading dose in adult intensive care patients.
European Society of Intensive Care Medicine Annual
Congress, Barcelona, Oct (poster).
37
 Varghese JM, Ranganathan D, Lipman J, Roberts JA.
Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD Study).
RBWH Health Care Symposium, Brisbane, Oct (poster).
 Varghese JM, McWhinney B, Ungerer J, Lipman J, Roberts JA. Subtherapeutic trough β-lactam levels in critically ill patients are associated with high creatinine
clearance. RBWH Health Care Symposium, Brisbane,
Oct (poster).
 Roberts JA, Douglas A, Jarrett P, Lassig-Smith M, Stuart J, Wallis SC, Medley G, Jenkins J, Lipman J. Perioperative plasma and tissue pharmacokinetics of cefazolin during abdominal aortic aneurysm repair surgery.
Interscience Conference on Antimicrobial Agents and
Chemotherapy, Boston USA, Sept (poster)
 Mazzei T, Breilh D, Kwa A, Montakantikul P, Roberts
JA, Gomersall C, Mutters R, Kuti J, Nicolau DP. Carbapenem Pharmacodynamics Against Contemporary
Non-fermenting Gram-negative Bacteria Isolated from
European and Asia-Pacific Hospitals. Interscience Conference on Antimicrobial Agents and Chemotherapy,
Boston USA, Sept (poster)
Kellie Stockton
 Stockton K, Wrigley T, Mengersen K, Paratz J, Kandiah
D, Bennell K. Quantification of muscle strength and test
retest reliability using hand held dynamometry in
women with Systemic Lupus Erythematosus and comparison to healthy controls. Asia Pacific League Against
Rheumatism ASM (poster)
Michael Steyn
 Qing Zhang, Chaoyi Pang, McBride S, Hansen D,
Cheung C, Steyn M. Towards health data stream analytics. 2010 IEEE/ICME International Conference on
Complex Medical Engineering, Gold Coast, July
Bernadette Bissett
 Australian Physiotherapy Association ACT Research
Symposium
Julie Varghese
 Varghese J, Ranganathan D, Lipman J, Roberts J.
Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD Study).
RBWH Health Care Symposium, Brisbane, Oct (poster)
 Varghese J, McWhinney B, Ungerer J, Lipman J, Roberts J. Subtherapeutic trough β-lactam levels in critically
ill patients are associated with high creatinine clearance. RBWH Health Care Symposium, Brisbane, Oct
(poster)
 Varghese J, Ranganathan D, Lipman J, Roberts J.
Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD Study).
SHPA National Conference, Melbourne, Nov (oral)
 Varghese J, McWhinney B, Ungerer J, Lipman J, Roberts J. Subtherapeutic trough β-lactam levels in critically
ill patients are associated with high creatinine clearance, SHPA National Conference, Melbourne, Nov
(oral)
Paul Gray
 Training program for the Australian College of Rural and
Remote Medicine
 Professional development workshop on pain management Pharmacy Australia Centre of Excellence
Kellie Stockton
 Arthritis Queensland Health Professional Education Day
(invited)
Jenny Paratz
 Instructor (PACCman course)
Workshops/Courses
Anthony Brown
 Medical Emergencies, The College Lecture Series,
FRACP Training Program, Brisbane.
Keith Greenland
 Airway Special Interest group (ANZCA) meeting, Lorne
Victoria.
Jason Roberts
 SHPA, Critical Care Seminar, Sydney, July.
Andrew Udy
 New Fellows Conference, Sydney, College of Intensive
Care Medicine.
Anthony Holley
 Rotor Wing Aeromedical Evacuation (RAAF), Townsville, Mar.
 Transfusion Science Course. Melbourne, Sept.
Weragoda Abeypala
 Pain Workshop for Nursing Education—Epidural anaesthesia/analgesia in pain management
 Obstetric Anaesthesia—Post-graduate Institute in Colombo, Sri Lanka
 Peri-operative Obstetric Education Day
 Ultrasound Imaging of Lumbo-sacral spine as an aid in
siting Epidural Blocks in Pregnant women. Society of
Obstetric Anaesthesia & Perinatology, San Antonio,
Texas.
38
Professional Organisation
Activities
Lipman, J.
 Member, RBWH Scientists Committee
 Member, RBWH Drug Committee and High Cost Drug
Sub-Committee
 Member, RBWH Divisional (CC&CSS) Executive Committee
 Member, Centre for Clinical Research Committee
 Member, Australian Red Cross Blood Service Advisory
Committee
 Faculty Member, European Society of Intensive Care
Medicine
 Editor (Intensive Care), Anaesthesia and Intensive Care
 Editor, ICU Management
 Editor, The Open Respiratory Medicine Journal
Paratz, J.
 RBWH symposium committee - member
 Australian College of Physiotherapists - Chief censor
 Cardiorespiratory Physiotherapy Australia - President
QLD branch
 Prince Charles Hospital Research Foundation – committee member
 European Society of Intensive Care Medicine – member
 Australian and New Zealand Intensive Care Society –
Member
 ANZBA – member scientific committee 2011
 Critical Care – Reviewer
 Critical Care medicine - Reviewer
 Anaesthesia and Intensive Care – Reviewer
 Neurobiology and Physiology – Reviewer
 NHMRC project & CCRE – Reviewer
 Faculty member for Queensland Skills Centre
Thomas, P
 Reviewer, low risk research applications, RBWH HREC
 Adjudicator, RBWH Health Care symposium
Brown, A.F.T
 Grants Advisory Committee of the QEMRF
 Scientific Advisory Committee of the QEMRF
 Co chair of the Academic Emergency Medicine Special
Interest Group, ACEM
 Undergraduate Education Committee — ACEM
 Editor-in-Chief - Emergency Medicine Australasia
 Committee member Acute Coronary Syndrome (ACS)
working group reporting to Statewide Cardiac Clinical
Network
 ACEM Trainee Research Committee
Rudd, M
 Treasurer of Australian and New Zealand Burn Association
 Medical Director of Queensland skin banking service
39
Steyn, M
 Chairperson, Anaesthesia and Peri-operative statewide
network
 Medical Advisory Panel for Queensland Health
 eHealth Research Investment and Advisory Committee
Gray, P
 Ongoing chair of the Queensland regional committee of
the faculty of pain medicine, ANZCA
 Honorary secretary of Medical Benevelont Association
of Queensland
Greenland, K
 Reviewer Anaesthesia and Intensive Care
 Reviewer British Journal Anaesthesia
Cohen, J
 ANZICs scientific committee for 2011 ASM
 CICM General examination committee
 Management committee for ANZICS steroid trial
 CICM examiner
 Director ICCEM course
 Reviewer, Anaesthesia and Intensive Care
 Reviewer, Critical Care
 Reviewer, Intensive Care Medicine
 Reviewer, Critical Care Medicine
Udy, A
 Member, Australian and New Zealand Intensive Care
Society
 Co-opted Member, Queensland Regional Committee,
College of Intensive Care Medicine (CICM)
 Reviewer, Anaesthesia and Intensive Care
 Convenor, Annual Qld Trainee Research Meeting, CICM
Stockton, K
 Co-chair, organizing committee Australian Rheumatology Association/Rheumatology Health Professionals
Association 52nd Annual Scientific Committee 2011
 Queensland Representative Rheumatology Health Professionals Association
Holley, A
 Lieutenant Commander, Royal Australian Navy Reserve
 Regional chair ANZICS Queensland
 EMST instructor
 Visiting specialist hyperbaric & diving medicine, RBWH
 Member of the critical care expert working group for the
National blood Authority
 Transfusion committee representative
Roberts, J.A
 Member of SHPA
 Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
 Australian Society for Medical Research (ASMR)
 American Society for Microbiology (ASM)
 Australian Society for Antimicrobials (ASA)
 European Society of Intensive Care Medicine (ESICM)
Muller, M
 Burns (Editorial Board)
 Injury (Editorial Board)
 J Burn Care and Rehabilitation (Editorial Board)
 Co-Chair Trauma review committee RBWH
 Qld Statewide Clinical Trauma Network 2005 Alert Doctors, RBWH 2007 Trauma Research Committee, RBWH 2006Starr, T
 Member of Association of Clinical Research Professionals
Spermon, M
 Burns and Trauma Interest Group – State wide teleconference network
 Australian and New Zealand Burns Association
Bissett, B
 Chair—ACT Health Physiotherapy Cross Program Meeting
40
Trauma Grand Rounds – Bi-monthly
 Trauma and Pregnancy – Assoc. Prof. Rebecca
Kimble
 Whickey Tango Foxtrot: Haiti 2010 – Assoc. Prof.
Kevin Tetsworth
 Anaesthetics in Afghanistan – Dr Michael Corkeron
 Burns in Trauma – Dr Steven Jeffrey
 A Long Journey Home: Tobias Vincent Story – RBWH
Trauma Service and invited presenters
Workshops
 Burns / Trauma Directors Workshop, RACS ACS Meeting, Perth. Assoc. Prof. Cliff Pollard, Dr Martin Wullschleger
 RACS Alcohol & Injury Workshop, Melbourne. Dr Martin Wullschleger, Jodie Ross
 2010 Queensland Road Safety Awards: Community
Engagement Workshop. Dale Dally-Watkins
 Trauma Education Day, Mackay. Assoc. Prof. Cliff
Pollard, Dr Martin Wullschleger
Conferences
 CENA Conference, Canberra. Kerena Grant, Michael
Handy
 Austrauma, Sydney. Dr Catherine Hurn
 Trauma Conference, Coimbatore, India. Dr Martin
Wullschleger
 RACS ACS Meeting, Perth. Assoc. Prof. Cliff Pollard,
Dr Martin Wullschleger
 SWAN XVIII Trauma Conference, Sydney. Assoc.
Prof. Cliff Pollard, Dr Martin Wullschleger
 70th ASM AOA, Adelaide. Dr Martin Wullschleger
Trauma 2010 conference, Melbourne. Dr Martin Wullschleger, Jodie Ross, Dr Catherine Hurn
Courses
 EMST Course, Auckland New Zealand. Dr Martin
Wullschleger
 EMST Courses (3), Brisbane and St. George. Assoc.
Prof. Cliff Pollard
 EMST Course, Perth. Dr Martin Wullschleger
 EMST refresher course, Townsville. Dr Martin Wullschleger
 DSTC Courses (February and November), Melbourne.
Assoc. Prof. Cliff Pollard, Dr Martin Wullschleger
 DSTC Course, Sydney. Assoc. Prof. Cliff Pollard
TNCC, Brisbane. Alice Brandt and Kerena Grant
Publications
Reichert JC, Epari DR, Wulschleger ME, Saifzadeh S, Steck
R, Lienau J, Sommerville S, Dickinson IC, Schutz MA, Duda
GN, Hutmacher DW: Establishment of a preclinical Ovine
Model for Tibial Segmental Bone Defect Repair by Applying
Bone Tissue Engineering Strategies. Tissue Eng, 16(1):93104, 2010.
41
Irie F, Pollard C, Bellamy N: Characteristics and outcomes of
injury patients in an Aboriginal and Torres Strait Islander
population – Queensland Trauma Registry, Australia. Injury
41(7):731-6, 2010.
Schmutz B, Rathnayaka K, Wullschleger ME, Meek J, Schuetz MA: Quantitative fit assessment of tibial mail designs
using 3D computer modeling. Injury 41(2):216-219, 2010.
Nijboer JMM, Wullschleger ME, Nielsen SE, McNamee AM,
Lefering R, ten Duis HJ, Schuetz MA: A comparison of severely injured trauma patients admitted to level one trauma
centres in Queensland and Germany. ANZ J Surg, 80:145150, 2010.
Chen G, Schmutz B, Wullschleger ME, Pearcy M, Schuetz
MA: Computational investigations of mechanical failures of
internal plate fixation. Proc Inst Mech Eng H, 224(1):119-26,
2010.
Schmutz B, Wullschleger ME, Meek J, Noser H, Barry M,
Schuetz MA: Fit optimization of a Distal Medical Tibia Plate,
Comput Methods Biomech Biomed Engin, May 7:1, 2010.
Sugiyama S, Wullschleger ME, Wilson K, Williams R, Goss
B: Reliability of clinical assessment for assessing spinal fusion: an experimental sheep study, accepted for publication
in Spine in October 2010.
Reichert JC, Wullschleger ME, Cipitria A, Lienau J, Cheng
TK, Schuetz MA, Duda G, Noeth U, Eulert J, Hutmacher DW:
Custom-made composite scaffolds for segmental defect repair in long bones, Int Orthop 2010.
Ueno M, Urabe K, Naruse K, Uchida K, Minehara H, Yamamoto T, Steck R, Gregory L, Wullschleger ME, Schuetz MA,
Itoman M: Influence of internal fixator stiffness on murine
fracture healing:two types of fracture healing lead to two distinct cellular events and FGF-2 expressions, accepted for
publication in Experimental Animals in October 2010 (EA-100053).
Steck R, Ueno M, Gregory L, Rijken N, Wullschleger ME,
Itoman M, Schuetz MA: Influence of internal fixatorr stiffness
on murine fracture healing as characterized by mechanical
testing and microCT imaging, accepted for publication to
JOR in November 2010.
TRAUMA
RESEARCH
GROUP
Presentations
 Hervey Bay to Herston. Assoc. Prof. Cliff Pollard, Trauma
Grand Rounds, Hervey Bay, February 2010.
 Management of Pelvic Ring Injuries. Dr Martin Wullschleger. In-service meeting, Trauma Service, RBWH, Brisbane, March 2010
 Damage Control Orthopaedics. Dr Martin Wullschleger.
Traumacon 2010, 13th Annual Conference of Trauma Society
of India, Coimbatore, India, April 2010.
 MIPPO – LCP in Distal Fractures of Tibia. Dr Martin Wullschleger. Traumacon 2010, 13th Annual Conference of
Trauma Society of India, Coimbatore, India, April 2010.
 Early Management of Unstable Pelvic Ring Injuries. Dr
Martin Wullschleger. Traumacon 2010, 13th Annual Conference of Trauma Society of India, Coimbatore, India, April 2010.
 Case Presentation (Interesting case discussion). Dr Martin Wullschleger. Traumacon 2010, 13th Annual Conference of
Trauma Society of India, Coimbatore, India, April 2010.
 Problematic Chest Trauma. Dr Martin Wullschleger. CME
Programme General Surgery, RBWH, Brisbane, April 2010.
 Contemporary Trauma Management. Assoc. Prof. Cliff
Pollard, Trauma Grand Rounds, Cairns, May 2010.
 The Queensland Trauma Plan Project. Assoc. Prof. Cliff
Pollard, Trauma Grand Rounds, Cairns, May 2010.
 Contemporary Trauma Management. Assoc. Prof. Cliff
Pollard, Trauma Grand Rounds, Townsville, May 2010.
 The Queensland Trauma Plan Project. Assoc. Prof. Cliff
Pollard, Trauma Grand Rounds, Townsville, May 2010.
 Major Limb Injuries. Dr Martin Wullschleger. Trauma
Education Day, PAH Brisbane, July 2010.
 Challenges in Management of Compound, Perineal Pelvic
Injuries. Dr Martin Wullschleger. SWAN XVIII Trauma Conference, Sydney, July 2010: prize for best presentation.
 Improving Trauma Outcomes – the effective administrator? Assoc. Prof. Cliff Pollard. SWAN XVIII Trauma Conference, Sydney, July 2010.
 Trauma Case Presentation. Dr Martin Wullschleger.
CME Programme General Surgery, RBWH, Brisbane, August
2010.
 Pelvic Trauma – stop the bleeding. Assoc. Prof. Cliff Pollard, Lismore Hospital Trauma Day, Lismore, August 2010.
 Trauma Queensland 1970-2010. Assoc. Prof. Cliff Pollard.
RACS Queensland State Committee Meeting, Gold Coast,
August 2010.
 Trauma 2010 in Queensland – where to go? Assoc. Prof.
Cliff Pollard. Redcliffe Hospital Grand Rounds, Redcliffe, September 2010.
 Trauma Service and Immediate Management of Trauma
Patients. Dr Martin Wullschleger. RMO Education, RBWH,
Brisbane, September 2010.
 Challenges in Management of Compound Perineal Pelvic
Injuries. Dr Martin Wullschleger. 70th Annual Scientific Meeting of Australian Orthopaedic Association, Adelaide, October
2010.

The front-line: burns, blasts and bullets. Dr Keith Towsey.
19th Annual RBWH Health Care Symposium, Brisbane. October 2010.
 Bleeding coagulopathy transfusion. Dr Catherine Hurn.
19th Annual RBWH Health Care Symposium, Brisbane. October 2010.
 Calling the ―Red Blanket‖ fast tracking the acute trauma
population. Michael Handy, Kerena Grant. 19th Annual RBWH
Health Care Symposium, Brisbane. October 2010.
 Red Blanket – priority zero. Kerena Grant, Michael Handy.
CENA Conference, Canberra, October 2010.
 Minimally Invasive Plating: Evidence and Clinical Application. Dr Martin Wullschleger. CME Department of Orthopaedic Surgery, RBWH, October 2010.
 Burns retrieval. Dr Keith Towsey. QLD Statewide Trauma
Symposium. Brisbane. November 2010.
 Liver trauma. Dr Richard Bryant. QLD Statewide Trauma
Symposium. Brisbane. November 2010.
 P.A.R.T.Y. (Prevent Alcohol and Risk-related Trauma in
Youth): The Royal Brisbane experience. Dr Martin Wullschleger, Jodie Ross, Dale Dally-Watkins. Trauma Committee
Workshop – Alcohol & Injury, Melbourne, November 2010.
 Novel Severe Trauma Model in Sheep and its Clinical
Application. Dr Martin Wullschleger. UQCCR Seminar,
RBWH, November 2010
 Pelvic Trauma. Dr Martin Wullschleger. Trauma Education Day, Mackay, December 2010.
 QLD Trauma plan / QLD Trauma Registry. Assoc. Prof.
Cliff Pollard. Trauma Education Day, Mackay, December 2010.
 Surgical preparation of trauma patients prior to transfer.
Assoc. Prof. Cliff Pollard. Trauma Education Day, Mackay,
December 2010.
 Toby Vincent‘s Case Presentation. Dr Martin Wullschleger. Trauma Grand Rounds, RBWH, Brisbane, December 2010.
 Abdominal trauma. Assoc. Prof. Cliff Pollard. Military
Trauma Workshop. 2HSB-RBWH, Brisbane, December 2010.
Complex pelvic trauma. Assoc. Prof. Cliff Pollard. Military
Trauma Workshop. 2HSB-RBWH, Brisbane, December 2010.
Journal Review activity
Assoc. Prof. Cliff Pollard for Journal of Trauma
Undergraduate teaching in School of Medicine, The University of Queensland
Tutorial: lumps, bumps & hernia (Year 2). Assoc. Prof. Cliff
Pollard and Dr Martin Wullschleger.
Tutorial: Early trauma management (Year 3). Dr Martin Wullschleger.
Higher research degree graduation
PhD awarded to Dr Martin Wullschleger by Queensland University of Technology.
42
NEW TO
BTCCRC
Therese Starr
Therese is a Research Coordinator with over 25 years experience
as a registered nurse predominantly in the area of Intensive Care
and Neurosurgial Intensive Care nursing. She has a number of
qualifications in both neuroscience and critical care and is a Certified ACRP-Clinical Research Coordinator. She has a total of 7
years experience in conducting and co-ordinating clinical trials, 6 of
those years spent at Q-Pharm, a Phase 1 clinical trials facility.
Here, she undertook the role of Study Coordinator to Project Management of Australian and International Phase 1 clinical studies.
Recently returning to Intensive Care in the role of research coordinator working on predominantly Phase 2-3 trials in the critically ill
patient in the Intensive Care setting, she brings with her a plethora
of clinical trials management experience necessary for the growing
number of trials conducted by our research centre.
Suzanne Parker-Scott
Suzie graduated from QUT in Chemistry before starting her career
as an Analytical Chemist in the pharmaceutical industry. With this
grounding in a highly regulated and commercial environment she
then moved into clinical chemistry research with The University of
Queensland‘s Centre for Studies in Drug Disposition (CSDD).
Suzie remained with CSDD when it formed the private company QPharm Pty Limited where she acted as a Senior Analytical Chemist
and Study Director. Suzie is currently working as a research assistant within our BTCCRC Analytical Facility. Suzie‘s outstanding
background in regulated commercial pharmaceutical laboratories
(Alphapharm, Starpharma, Q-Pharm) as well as in academic clinical research (CSDD), brings a wealth of knowledge, experience
and technique to our measurement of drugs and metabolites in
clinical trials.
43
QUEENSLAND
Dr Helen Healy, Dr Adrian Kark,
Dr Dwarka Ranganathan, Prof Rob Fassett,
Dr Vincent D'Intini
Department of Renal Medicine
Royal Brisbane & Women’s Hospital
Dr Merrilyn Banks, Dr Lynda Gillen, Sharon Forbes
Department of Nutrition and Dietetics
Royal Brisbane & Women’s Hospital
Prof David Paterson
Consultant Infectious Diseases Physician and
Microbiologist
Royal Brisbane & Women’s Hospital
Professor of Infectious Diseases,
University of Queensland
A/Prof S Brauer
School of Health & Rehabilitation Sciences
University of Queensland
A/Prof Carl Kirkpatrick
School of Pharmacy
University of Queensland
A/Prof Paul Mills
Vet Pathology & Anatomy
University of Queensland
Prof Paul Colditz, Dr Barbara Lingwood
Perinatal Research Centre
University of Queensland
Prof Alastair McEwan, Prof Michael Jennings,
A/Prof Mark Schembri , Dr Scott Beatson
Molecular & Microbial Sciences
University of Queensland
A/Prof Graham Nimmo
Queensland Health Pathology Service
Prof Michael Roberts, Dr Greg Medley
Dr Sheree Cross, Dr Thomas Robertson
Therapeutics Research Unit
University of Queensland
Prof Zee Upton
Professor and leader of the Tissue Repair & Regeneration
Program, School of Life Sciences.
Queensland University of Technology
Dr Phillip Cowlishaw
Mater Hospital
Prof Claire Rickard
Device Research Group
Research Centre for Clinical & Community Practice Innovation & School of Nursing & Midwifery
Griffith University
Dr Peter Kruger, Prof Bala Venkatesh, ICU
Dr Geoff Playford, Infectious Diseases (ID)
Princess Alexandra Hospital
A/Prof John Fraser- Intensivist
ICU & Animal Research Centre
The Prince Charles Hospital
Dr Jonathan Field,
Intensive Care Unit,
Gold Coast Hospital
Dr James Lind
Dept of Emergency Medicine
Gold Coast Hospital
School of Medicine
Griffith University
Dr Christopher Hammet
Dr William Parsonage
Department of Cardiology
Royal Brisbane & Women’s Hospital
Ms Jill Tate
Pathology Queensland
Royal Brisbane & Women’s Hospital
Dr Jacobus Ungerer
Dr John Cardinal
Chemical Pathology
Royal Brisbane and Women’s Hospital
Dr Nana Sunn
Queensland Brain Institute
University of Queensland
Dr Queenie Lau, Dr Thomas Robertson
Department of Pathology
Royal Brisbane & Women’s Hospital
Dr Ian Shiels, A/Prof Steve Taylor
Department of Physiology & Pharmacology
University of Queensland
Prof Gerry FitzGerald
School of Public Health
Queensland University of Technology
44
Casey Pfluger
Neuroimmunology Research Group,
University of Queensland Centre for Clinical Research
A/Prof Steve Webb, Dr Geoff Dobb, Dr KM Ho ICU
Dr Andrew Heard, Dr Richard Riley
Royal Perth Hospital
Craig Readdy
Department of Medical Imaging
Royal Brisbane and Women’s Hospital
A/Prof Debbie Marriott - ID/Microbiology
Dr Sam Rudham – ICU
St Vincent’s Hospital, Sydney
Dr Claire Simpson
Skin Culture Facility
Royal Brisbane and Women’s Hospital
Dr Shane Patman
Notre Dame University, Perth
Dr Dianne Stephens
ICU
Royal Darwin Hospital
Professor Kerrie Mengersen
Department Mathematics,
Queensland University of Technology
Lisa New
School of Information Technology and Electrical Engineering
University of Queensland
NATIONAL
Dr Charudatt Shirwadkar
Blacktown Hospital
Elizabeth Skinner
Senior ICU Physiotherapist,
Monash Medical Centre, Melbourne
Dr. Reny Segal
Royal Melbourne Hospital
Prof Nick Taylor
La Trobe University, Melbourne
Dr. Chris Acott
Royal Adelaide Hospital
A/Prof Jon Iredell, Prof Tania Sorrell, Dr Heather Giddings
Centre for Infectious Diseases and Microbiology,
Dr Catriona Halliday - Molecular Mycology Laboratory
Dr John Gallagher - ICU
Westmead Hospital, Sydney
Prof Kim Bennell
Centre for Health, Exercise and Sports Medicine
School of Physiotherapy
University of Melbourne
A/Prof David Tuxen, A/Prof Carlos Scheinkestel,
Dr Andrew Davies - ICU
A/Prof Denis Spelman – Microbiology
Dr Alex Padiglione – ID
A/Prof Anne Holland, Carol Hodgson—Physiotherapy
Alfred Hospital, Melbourne
Dr Anne Leditschke, Ms Margot Green
Canberra Hospital
INTERNATIONAL
A/Prof Charles Gomersall, Prof Gavin Joynt,
Dr Gordon Choi, Prof Michael Irwin
Anaesthesiology & Intensive Care
Chinese University of Hong Kong
Prof Rinaldo Bellomo,
Ms Sue Berney - ICU
Prof Lindsay Grayson - ID
Dr Barrie Mayall - Microbiology
Austin & Repatriation Hospital, Melbourne
Prof Alice Jones
Hong Kong Polytechnic University
Prof John Myburgh, Prof Simon Finfer
The George Institute for International Health, Sydney
Dr George Ntoumenopolous
St Thomas & Guys Hospital Trust, London, UK
Dr George Kotsiou
ID/Microbiology
Royal North Shore Hospital, Sydney
Prof Wolfgang Krueger
Department of Anesthesiology and
Intensive Care Medicine,
Tübingen University Hospital, Germany
Dr Joshua Davis,
Menzies School of Health Research, Darwin
45
Dr Noelle Lim,
Dept of Anaesthesia & Surgical Intensive Care,
Changi General Hospital, Singapore
A/Prof Andrew Shorr
Pulmonary & Critical Care Medicine
Washington Hospital Center, USA
Prof Jordi Rello
Critical Care Department
Joan XXIII University Hospital,
University Rovira & Virgili, Spain
Prof Paul Marik
Pulmonary and Critical Care Medicine,
Thomas Jefferson University
Philadelphia, USA
Prof Satish Bhagwanjee,
Ms Juan Scribante
Dept of Anaesthesia
University of Witwatersrand, South Africa
Dr J Baptista
Coimbra University Hospitals, Portugal
Prof Mervyn Singer, Dr Alberto Corona
Bloomsbury Institute of Intensive Care Medicine
University College London, UK
Dr F Taccone
Erasme Hospital, Free University of Brussels
Dr Guido Bertolini
Laboratory of Clinical Epidemiology,
Institute of Pharmacological Research
Italy
Dr A Peter Wilson
Department of Microbiology,
University College London, UK
Dr Martin Than
Department of Emergency Medicine
University of Otago, New Zealand
Prof M Kollef
Washington University, Missouri, USA
Prof George Dursano
Ordway Research Institute, New York, USA
Dr Shahed Omar, Chris Hani
ICU
Baragwanath Hospital, Johannesburg, South
Africa
Prof Alan Merry
University of Auckland, New Zealand
Prof Jamie Sleigh
Waikato Clinical School of Medicine, New Zealand
Prof Andries Gous
School of Pharmacy
University of Limpopo, South Africa
46
Projects for Honours, postgraduate (Masters and PhD) and postdoctoral researchers are possible through the
Burns Trauma & Critical Care Research Centre. There is high expertise in postgraduate supervision within our
research centre.
The centre is also keen to support clinical staff who wish to undertake research projects.
Prospective candidates can obtain further information about postgraduate study from the UQ Graduate School
home page at http://www.uq.edu.au/research/grad-school. This page contains application forms, scholarship
details and information for international students.
Enquiries about research areas and projects that are available should be directed to the Director or Chair:
Professor Jeffrey Lipman
Director, Intensive Care Unit, Royal Brisbane and Women‘s Hospital and
Director, Burns Trauma & Critical Care Research Centre
Email [email protected]
Phone 61 7 3636 1852
Fax 61 7 3636 3542
Dr Jenny Paratz
Chair, Burns Trauma & Critical Care Research Centre
Email [email protected]
Phone 61 7 3636 1980
Fax 61 7 3636 3542
Postal Address
Burns Trauma & Critical Care Research Centre
Block 6, Level 7
Royal Brisbane and Women‘s Hospital
QLD, Australia, 4029
47
Burns Trauma & Critical Care
Research Centre
MAJOR SPONSOR
SUPPORTING SPONSORS
Your funding support of clinical research , training and
education is greatly appreciated. Please contact:
Royal Brisbane & Women‘s Hospital Foundation,
PO Box 94
Royal Brisbane & Women‘s Hospital QLD 4029
Phone (07) 3636 7588 or free call 1300 363 786
Email: [email protected]
Web site: www.rbwhfoundation.com.au