AnimalNEWS - Morris Animal Foundation
Transcription
AnimalNEWS - Morris Animal Foundation
A H E A L T H I E R T O M O R R O W F O R IN THIS ISSUE Special Report: Healing Animal Aches and Pains A N I M A L S® 12.2 volume IN THIS ISSUE 0 1 Snuff out the ouch 08 No squawking when it comes 03 A postoperative pop of pain relief 04 New tools get to the heart of 09 New wildlife studies help a multitude of species worldwide feline aches 12.2 to pain 05 Unique characteristics make 09 Say it with an eCard 06 On a cold-blooded crusade 12 Cancer campaign funds nearly 10 Your donations at work horses prone to pain 13 Your monthly gift makes a world of difference 13 Join us online 14 In loving memory 16 Chance encounter leads to lifelong puppy love $5 million in research in five years D E A R FRI ENDS, AnimalNews In the early 1800s, phrenology (the belief that the shape and features of one’s head determine the physiology of the body) was considered the state of medical arts. Likewise, in veterinary schools during the 1970s, students were taught that pets should not receive pain relief following surgery or injury because pain helps animals stay quiet, thus allowing them to heal faster. Thankfully, both schools of thought have been disproven through scientific study. Sometimes it takes time, scientific study and persistence to prove, or disprove in this case, something that seems obvious in retrospect. Today, veterinarians know that we should treat pets for pain, and pain control is a welcome and critical aspect of all clinical medicine. But it is still not easy because some animals are stoic, some pain signals are hard to perceive and some species give no outward indications until the pain is severe. Thanks to research in this area, we now have tools to help us understand when an animal is suffering. As president and CEO of Morris Animal Foundation, I’m really proud of the role the Foundation has played—and continues to play—in improving pain management for pets. This issue of AnimalNews focuses on how your donations have supported innovative science that helps veterinarians diagnose and treat pain in pets and exotic animals. We even share some tips to help you identify when your pet is in pain. I also want to point out Morris Animal Foundation’s new, more simplified logo, which you can see on the cover of this issue. The Foundation is a leader in cutting-edge veterinary science, and we wanted a logo that reflects our forward thinking. At the same time, we are proud of the four-animal emblem—created nearly 40 years ago—that symbolizes our scope. We hope our updated look captures where Morris Animal Foundation has been and where it’s going. Let us know what you think at [email protected]. Enjoy a safe and sunny summer with the animals you love. And thanks for all you do to advance animal health. Volume 12 Issue 2 May 2012 Kind regards, OUR MISSION Morris Animal Foundation improves the health and well-being of companion animals and wildlife by funding humane health studies and disseminating information about these studies. AnimalNews is published four times a year by Morris Animal Foundation. 10200 East Girard Avenue Suite B430 Denver, Colorado 80231 TOLL-FREE 800.243.2345 P 303.790.2345 www.MorrisAnimalFoundation.org David Haworth, DVM, PhD President/CEO Join us on Facebook at www.facebook.com/morrisanimal. Special Report: Healing Animal Aches and Pains Snuff out the ouch B y K elle y W eir Common pain relievers for pets Safety characteristics of pain relievers are very different in humans and animals. Never give your pet a drug without first checking with a veterinarian. Veterinarians have different drugclass options to choose from when treating pain in pets. • Nonsteroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory and analgesic • Opioids are reversible and have a short duration of action • Alpha-2 agonists are sedatives that also have analgesic properties • Local anesthetics and topical anesthetics block pain pathways Humans have been controlling their own pain for thousands of years—not so for animals. Just two decades ago, a graduating veterinarian would have completed relatively little course work that addressed pain management in pets because the standard thinking was that pain management could actually cause animals to injure themselves more. Thankfully, things have changed drastically over the years, and research has shown the importance of pain alleviation in the healing process. Veterinarians now have the knowledge and training to offer pet owners many options for treating pain in the furry and feathered friends who share their homes. Pain management for animals has come a long way, and Morris Animal Foundation has become a leader in funding pain management studies for all animals. In the last two decades alone, the Foundation has increased its funding by 67 percent for studies that focus on pain management for animals. This increase was in line with an industry trend that began in the early 2000s, when pet owners and veterinarians began demanding more information and options. Tuning in to pain type What began as trying to manage pain in pets after injury or illness now includes preventive measures to reduce or www.MorrisAnimalFoundation.org avoid pain altogether. Dr. Mike Petty, president of the International Veterinary Academy of Pain Management, says, “Animals feel pain as much, if not more, than we do, yet due to survival instincts they try to hide their pain.” There are two types of pain: acute and chronic. Acute pain is usually temporary and results from something specific, such as surgery, an injury or an infection. Chronic pain lasts beyond the term of an injury or painful stimulus, but it can also refer to cancer pain, pain from a chronic or degenerative disease and pain from an unidentified cause. Dr. Petty points out that, regardless of whether pain is chronic or acute, animals tend to hide their symptoms. The goal of veterinarians—and pet parents—is to see through the facade. A position paper by the American College of Veterinary Anesthesiologists on treatment of pain in animals states that the prevention and alleviation of pain in animals is a central, guiding principle of practice. Those in the industry advocate that animal pain and suffering are clinically important conditions that affect an animal’s quality of life, and that methods to prevent and control pain must be tailored to the animal. “The trend of pain prevention has resulted in research that is trying to validate both acute and chronic pain scales to better understand when animals are in pain,” Dr. Petty continued on ne x t pag e 1 Special Report: Healing Animal Aches and Pains S nuff out the ouch , C O N T. says. “There is also a big move for pharmaceutical organizations to develop specific pain medications or delivery systems so that we don’t have to rely on crossover from human medications.” Morris Animal Foundation is doing its part to find solutions. For example, the Foundation is funding several studies that are establishing subjective pain scales for companion animals, some of which are described in this issue. Dealing out the right dose In addition, some Foundation-funded scientists are working to establish proper dosing or administration techniques for drugs that are already approved by the U.S. Food and Drug Administration for use in humans. These medications offer potential solutions to pain, but because drugs are metabolized differently in animals than in humans, the dosing must be appropriate. The research team will have the information and ability to perform genetic testing as part of future studies if important correlations are found. “This study is the foundation for future research on the effectiveness of orally administered analgesics, such as carprofen, in dogs and should answer some important questions many veterinarians and owners have about this particular drug,” she says. Pain management is not only good for pets but it benefits owners and veterinary practitioners as well. Patients enjoy improved quality of life, owners maintain the bond with their pets and veterinary teams experience improved morale and job satisfaction. When pain loses, everybody wins. B “As veterinarians, we really need to know if these drugs work,” Dr. Petty says. “But without research, as we use these human drugs, we can go into uncharted territory.” Not only do different species react differently to certain drugs, but individual animals also have unique reactions. Some pets respond positively to pain medications, called analgesics, while some don’t experience an effect or suffer negative side effects. With funding from Morris Animal Foundation, Dr. Kristen Messenger, a veterinary anesthesiologist and researcher from North Carolina State University, is exploring reasons for these differences. She is looking at age, breed, sex, concurrent illness and how the drug carprofen is given to dogs, and she will then evaluate how these factors may contribute to diverse responses. Carprofen (trade name Rimadyl) is a commonly used pain medication for dogs. She will also look for alterations in plasma concentrations, or how the drug is absorbed, which may predispose a dog to develop adverse drug reactions. While many studies analyze medications using healthy animals, Dr. Messenger’s study is unique in that she will monitor dogs that are already on the medication for preexisting conditions. “This particular drug is the most commonly used drug at our veterinary teaching hospital, which shows how important this research will be,” Dr. Messenger says. 2 Plan ahead for your pet Pain management is an integral part of diagnosis and treatment. If your pet must undergo a painful procedure, plan with your veterinarian in advance for managing pain afterward. Fully discuss the expected needs of your pet and outline a therapy plan early in your pet’s care. The most important role you can play in managing your pet’s pain is to follow veterinary medical instructions completely and to finish all medications as directed. Another note of caution from Dr. Mike Petty, president of the International Veterinary Academy of Pain Management, is that you should always consult a veterinarian before giving an animal any type of medication, even herbal supplements, and be sure to tell your veterinarian if your animal is already being treated with another medication. A postoperative pop of pain relief B y L i z D e v itt Research shows that novel drug formulation works in just one shot Dr. Lesley J. Smith, a board-certified veterinary anesthesiologist at the University of Wisconsin, knows the importance of pain management firsthand. She remembers how, years ago, when her first dog developed complications from cancer and needed limb amputation surgery, she had to scramble to get more medication when the analgesics her dog had already taken weren’t strong enough to keep the pain at bay. More recently, Morris Animal Foundation funding allowed Dr. Smith to study a better way to treat postsurgical pain in dogs. “Right now, our standard of care for relief of severe pain requires an intravenous catheter, intensive care nursing and continuous infusions of drugs,” Dr. Smith explains. “Currently, there’s nothing commercially available that is effective, long lasting and easily administered. Our study looked at a single-injection drug, given under the skin, that lasts at least three days.” What’s the wonder drug? Hydromorphone, an opioid that has provided pain relief for decades. Although the drug is commonly used, a new formulation makes it easier to administer. Dr. Smith and her co-investigators reformulated hydromorphone into a lipid-based vesicle—called a liposome—that slowly releases the drug to deliver a steady stream of pain relief. “Most people are familiar with patient-controlled analgesia, where a person has an IV catheter and pushes a button for more medication,” Dr. Smith says. “Our pets can’t do that for themselves, though, so this formula of the drug DPPC-C hydromorphone is a chemical way to achieve that.” www.MorrisAnimalFoundation.org Photo courtesy of Dr. Lesley J. Smith When our pets hurt we ache for them, but managing pain in pets isn’t easy. Even though pain is considered the fourth vital sign, it’s hard to treat when animals hide their discomfort and when many medications prescribed for people are not as effective or have not been validated as effective in pets. Dr. Lesley Smith’s passion for pain management began with her first dog. Today, lovable Wilma provides inspiration. In earlier research, also funded by Morris Animal Foundation, Dr. Smith and Dr. Lisa Krugner-Higby studied the metabolism and side effects of DPPC-C hydromorphone in a group of healthy Beagles. Using the information they collected, they studied the new hydromorphone formulation in pets that needed major surgery. Their results show that a single dose of DPPC-C hydromorphone is as effective as the current standard of care for pain relief. An added bonus is that it doesn’t cause unexpected side effects and requires far less intensive care. Although there aren’t any plans to commercialize this drug formulation right now, Dr. Smith’s work paves the way for finding other formulations of longacting pain medications. With less pain, our pets have everything to gain. B 3 Special Report: Healing Animal Aches and Pains New tools get to the heart of feline aches B y K elle y W eir Have you ever watched a cat jump off a high countertop and the first thought that pops into your mind is, “Wow, that’s gotta hurt!” And yet, the cat doesn’t seem phased at all. A cat’s ability to hide pain is almost legendary. In the wild, an animal that is ill, lame or crying out in pain is vulnerable to attack, but in a domestic setting, being stoic could affect a cat’s quality of life because it may not get effective pain management—and that can lead to poor recovery after injury or surgery or a lack of treatment for illness. Chronic pain—and the resulting behavioral changes— can also affect the bond between cats and their owners, which can to lead to relinquishment and unnecessary euthanasia. That is why there is more focus on developing tools to help veterinarians and owners subjectively measure pain in cats. Masters of disguise Research suggests that owners are less likely to take cats to the veterinarian during their older years, when they may experience chronic pain. Dr. Mike Petty, president of the International Veterinary Academy of Pain Management, stresses that veterinarians are the best resource for identifying if and why a cat is in pain and for determining the best way to manage it. In addition to routine veterinary care, it’s important to look for subtle behavior changes: • Decreased appetite • Hiding Building tools to gauge pain • Decreased activity The older the cat, the more susceptible it is to experiencing chronic pain from osteoarthritis. Traditionally, the disease has been underdiagnosed in cats because symptoms can be subtle. Using Morris Animal Foundation funding, researchers from the University of Montreal, Drs. Mary Klinck and Eric Troncy, are developing two different arthritis pain scales for cats: one designed for use by owners and another for use by veterinarians. So far, their work shows promise, and next steps for the project include laboratory trials to increase the tests’ sensitivity and make them even better at detecting pain. • Lethargy At North Carolina State University, another study funded by the Foundation is also building a tool for diagnosing pain. Dr. Duncan Lascelles is developing a subjective owner-based questionnaire that could help owners and veterinarians assess how well cats are responding to treatments. These assessment tools are currently being vetted for validity and sensitivity but could be promising to future researchers and veterinarians in reducing pain in cats. B 4 • Decreased grooming • Inappropriate waste elimination • Vocalization • Aggression • Decreased interaction with other pets and family members • Altered facial expression or posture • Restlessness • Increased body tension or flinching in response to a gentle touch • Physical signs, such as elevations in heart rate, rapid breathing, higher body temperature and blood pressure or dilated pupils Unique characteristics make horses prone to pain B y K elle y W eir While the options for alleviating pain in cats and dogs have improved significantly over the past decade or so, there is much to be learned about which drugs will work best for horses’ unique physiology and anatomy. Large animal veterinary researchers are working hard to learn more about improving pain management in horses. inflammation by sending neutrophils, a type of white blood cell, to the site, but sometimes the neutrophils overreact and thus damage the tissue. With Morris Animal Foundation funding, Dr. Jones is studying how these cells orchestrate the inflammatory response and evaluating a new drug that may keep the neutrophils from overreacting. Dr. Samuel Jones, assistant head for equine programs at North Carolina State University’s College of Veterinary Medicine, points out three characteristics that are special to horses: their gastrointestinal tract, their susceptibility to endotoxemia and their vulnerability to laminitis. These three characteristics, he says, set horses apart from companion animals and pose a challenge to veterinarians who treat them. “The compound we are studying is not going to control pain, but it may control the overreaction of neutrophils that leads to pain,” Dr. Jones explains. “A lot of how we treat pain in horses has been derived from research that has been done for companion animals and humans,” he says, “but we have to be careful because there can be differences in how horses respond to different drugs or how they experience pain, for that matter.” Though much is left to learn, the good news is that pain management for horses has made great strides in the past 20 years ago. Dr. Jones explains that specific research is needed on equine pain management, and he’s one of the scientists doing just that. Specifically, he’s looking at how horses react to treatment. The immune system reacts to injury or This could be an important breakthrough for horses because they are susceptible to endotoxemia, a condition in which harmful bacteria in a horse’s gut get into the bloodstream, which can cause shock, colic-like symptoms, laminitis and even death. “Clinicians have all realized how important pain management is for a successful outcome,” Dr. Jones says. “Horses do much better clinically if we can control pain. That’s why there’s been an explosion of interest in the topic and importance placed on finding the best treatments.” B Signs of pain in horses • Restlessness • Sweating • Rigid stance • Dilated pupils • Muscle tremors • Reluctance to move • Abnormal gait • Reduced appetite www.MorrisAnimalFoundation.org 5 Special Report: Healing Animal Aches andReport: Pains Pain Management and Animal Health Special On a cold-blooded crusade B y A le x J imene z Researchers work to conquer pain in exotic animals Scientists now know that answer was wrong. And fortunately for those, like you, who love animals, the management of pain and suffering is now viewed as a critical part of animal health and care. Still, we are often guilty of playing favorites. In the case of veterinary medicine, the bounty given to advancing the health of domestic animals greatly exceeds what is allotted to their exotic counterparts. Nowhere is this more evident than in pain management research for exotic animals. Fortunately, new research funded by Morris Animal Foundation is addressing pain management in several exotic species, and scientists are now poised to answer questions about pain more thoroughly than ever before. Study breaks through the pain barrier When it comes to understanding pain, reptiles are among the most elusive animals to treat. In fact, reptile pain has been so understudied that most veterinarians traditionally have to use methods applied in mammalian species. Sadly, this can lead to less successful and even fatal treatments. With the help of Morris Animal Foundation funding, University of Wisconsin researcher Dr. Kurt Sladky is changing things for reptiles. In 2006, Dr. Sladky took on what is now considered to be the first-ever study to examine effective analgesic treatments in reptiles. He focused on red-eared slider turtles, the most popular pet turtle in the United States, and proved that butorphanol tartrate, the commonly used analgesic in reptiles, is not an adequate pain reliever in this species. Not only is it ineffective, but his research also showed that the drug can cause mild respiratory depression. “This is not something you really want happening in an animal that lives in water,” Dr. Sladky notes. 6 Photo courtesy of Dr. Kurt Sladky For centuries philosophers and scientists have debated the question, “Can animals feel pain?” Until about three decades ago, the answer to that question was thought to be “no.” Researchers are trying to provide effective pain relief for turtles that suffer propeller blade injuries. Fast forward to 2012, and Dr. Sladky is giving even more relief to our cold-blooded companions by learning more about what pain medication does work. In studies funded by Morris Animal Foundation, Dr. Sladky first demonstrated that the drug tramadol is a low risk and effective analgesic in red-eared slider turtles. Then, he took these data into the field, where he tested the efficacy of tramadol on loggerhead sea turtles—a highly endangered turtle found in oceans throughout the world. His study yielded strong results. To accomplish his research on loggerheads, Dr. Sladky teamed up with Dr. Terry Norton, director and veterinarian of the Georgia Sea Turtle Center. “This work on pain management is important when these turtles have issues,” Dr. Norton explains. “We have not had effective pain management in these species until now, and it can really increase their survival and rehabilitation rates.” Sadly, sea turtles experience a lot of painful issues. Propeller blade injuries are notorious for killing or disfiguring them. In addition, complications due to dredging, fishing lines and pneumonia are among the many issues that can debilitate a sea turtle. Measuring suffering in voiceless creatures Measuring pain in any animal can be difficult, but in species that can’t bark, whimper or cry, it can be an especially slippery task. For Dr. Sladky, this question is paramount to his research. “The question of ‘How do I measure pain?’ must come before the question ‘What drugs do I use?’” Dr. Sladky says. And Dr. Sladky believes any measurement of pain needs to take emotional suffering into account. He cites a chilling example from human medicine that reinforces his belief in giving the benefit of the doubt when dealing with pain. “Even just 40 years ago, human medicine adhered to the idea that the brains of newborn babies were too immature to experience pain,” he recounts. “In turn, they never received any pain medications, even after very invasive surgeries.” In another one of Dr. Sladky’s studies funded by Morris Animal Foundation, he and his laboratory colleague, Dr. Tracie Baker, measured the efficacy of several analgesic drugs in koi (the large Japanese fish) by monitoring attributes that dictated how well the fish could eat, swim and react to other stimuli after surgery. Understanding drug dosing in reptiles Studies are leading to less suffering for injured and ill bearded dragons, which are commonly kept as pets. Although this research is opening doors for managing pain in cold-blooded species beyond turtles and fish, there is more to be done. butorphanol, morphine, tramadol, carprofen, ketoprofen and meloxicam. In other Morris Animal Foundation–funded studies at the University of Tennessee, principal investigator Dr. Cheryl Greenacre’s research into the pain management of bearded dragons is making strides for lizards. She and a team of researchers developed a valid test for monitoring pain in reptiles and then used that test to evaluate the effectiveness of various pain-relieving medications in bearded dragons. They determined dosages for a number of medications that can provide some pain relief in bearded dragons, including www.MorrisAnimalFoundation.org Looking forward, Dr. Sladky hopes to use his research to learn more about managing pain in snakes. “These animals have incredible abilities,” Dr. Sladky emphasizes. “Their level of understanding and how they experience the world might be more complicated than we will ever know.” We’re happy that crusaders for cold-blooded creatures, like Drs. Sladky and Greenacre, keep pushing for answers. B 7 Special Report: Healing Animal Aches and Pains No squawking when it comes to pain B y A m y E ttin g er camera, because a bird will alter its behavior if it thinks it’s being watched. The apparatus is a perch that warms up, and if the bird feels that the perch is too hot, it will lift its foot, causing the perch to automatically cool down. “If a bird is on a warm perch and is given analgesic, its pain threshold is higher, and it won’t lift its foot as quickly,” says Dr. Paul-Murphy. With Foundation funding, Dr. Paul-Murphy and her colleague Dr. David Guzman have also studied how nalbuphine, a morphine-like drug, affects parrots. Her studies in this area found that nalbuphine works for about three to four hours. Hoping to find a longer-lasting drug, they continued the research by looking at the effects of tramadol in parrots. Long-lasting pain relief is in the pipeline for parrots and kestrels. Researcher finds ways to evaluate and treat pain in birds A dog may limp when in pain. A cat can hide or hiss. But sick birds often show no symptoms at all until an injury becomes debilitating. Dr. Joanne Paul-Murphy of the University of California–Davis is a renowned expert in pain management for birds, and thanks to Morris Animal Foundation funding, she has learned a lot over the years. “Birds are programmed to show that nothing is bothering them. They don’t whine or cry,” says Dr. Paul-Murphy. “Birds are not really domesticated, and so we haven’t really learned to understand when a bird is in pain.” To carry out the research, her scientific team developed an apparatus to test the birds’ discomfort without causing any real pain or injury. The apparatus is outfitted with a hidden 8 “Tramadol is given orally but may not provide as much pain relief as butorphanol,” says Dr. Paul-Murphy. It does have a few advantages, however: “We can send patients home with it, and it provides pain relief for a longer period of time.” Recently, Dr. Paul-Murphy and Dr. Guzman teamed up to look at the effect of different pain-relief drugs on raptors. The researchers are learning that analgesics work very differently in different avian species. “A parrot is as different from a kestrel as a cat is from a horse,” says Dr. Murphy. The team chose to work with American kestrels because they are very common in wildlife rehabilitation facilities. So far, the results have been very surprising. “We see great differences when compared with the other species of birds we evaluated,” Dr. Guzman says. “This is very important because it will help veterinarians to make the right choice regarding which opioid drug, and at what frequency, to provide it to kestrels and, by extrapolation, to some other raptors in pain. It will ultimately improve their welfare and health.” B New wildlife studies help a multitude of species worldwide Part of Morris Animal Foundation’s unique contribution to animal health is that our mission includes helping wildlife. And not only do we fund wildlife health research, but the Foundation is often the only source of funding for wildlife scientists. So much so, that a number of wildlife researchers have called Morris Animal Foundation the National Institutes of Health for wildlife funding. Support from Morris Animal Foundation fills a major void in funding for wildlife health. At our March Wildlife Scientific Advisory Board meeting this year, we committed to $1.9 million in funding for wildlife studies over the next three years. That includes more than $775,000 for 18 continuing studies and just over $1.1 million for 13 new studies. These studies address a vast array of health issues that affect captive and free-range wild animals worldwide. Just a few of the issues that will be addressed are pneumonia that is killing off bighorn sheep; deadly infectious diseases that are wiping out species of amphibians and bats; environmental contaminants affecting ducks in Argentina, birds in North America and marine life in the Gulf of Mexico; pain management in raptors; reproductive issues in elephants; stress-related illnesses in captive cheetahs; and decreasing disease transmission rates for lions, rhinos and tigers living in the wild. B Learn more www.MorrisAnimalFoundation.org Say it with an eCard Our holiday eCards were such a hit last year, that we’ve expanded our line of cards. Now, you can send an environmentally friendly eCard to memorialize a pet, send birthday or get well wishes, welcome a new pet or say congrats or thank you. There’s even an option for your pet to send a card to a special someone. The best part? Your donation supports research that advances animal health. So not only does your card brighten the day for that special someone, but your gift makes the world a healthier place for animals everywhere. B View more View all of the cards at www.MorrisAnimalFoundation.org. www.MorrisAnimalFoundation.org 9 Your donations at work Your donations truly make a difference in the lives of animals worldwide. At any given time, Morris Animal Foundation manages about 300 active studies. Here’s a look at some recent successes made possible through your support. For dogs Lack of bacteria increases risk of urinary stones Dr. Michael P. Murtaugh University of Minnesota Urinary stones are a common problem in dogs, and one that can cause lifethreatening obstruction of the urinary tract. It is suspected that natural bacteria in the gut can help prevent this condition. For dogs Study identifies potential bone cancer therapy Dr. Cheryl A. London The Ohio State University Osteosarcomas account for about 5 percent of all tumors in dogs. This type of cancer has a very high risk of spreading, particularly to the lungs. It is also aggressive, and treatment often requires amputation of the affected limb coupled with chemotherapy to provide temporary relief from this disease. Through this study and Morris Animal Foundation funding, researchers identified a new target for therapeutic intervention for this type of bone cancer. Information gained from the study has led to a clinical trial for dogs with osteosarcoma. So far, early results are encouraging. Using Morris Animal Foundation funding, researchers from the University of Minnesota examined natural bacteria in healthy dogs and compared them to those in dogs with urinary stones. They confirmed that a lack of certain types of bacteria in the gastrointestinal tract of dogs increases the possibility that the animal will develop urinary stones. The team was able to produce three probiotic bacteria that have the potential to be used for preventing and treating urinary stones in dogs. This study also provided research training for a veterinary graduate student who has now received her PhD and accepted a postdoctoral fellow position to study vaccine development at the University of Minnesota. For cats Research makes asthma shots safer Dr. Carol Reinero and Dr. Chee-Hoon Chang University of Missouri An estimated 1 to 5 percent of pet cats suffer from asthma caused by immune reactions to inhaled allergens. Previous Morris Animal Foundation–funded studies indicated that allergy shots show promise as a potential cure; however, these shots can take months to work, and most cats require concurrent treatment with steroids to control serious symptoms. 10 With continued Foundation funding, researchers from the University of Missouri examined whether treatment with steroids can affect testing for asthmacausing allergens and whether steroids reduce the efficacy of the allergy shots. They determined that allergy testing can proceed while cats are taking steroids. They also found that inhaled steroids are the preferred long-term treatment to control symptoms while allergy shots are being given. These findings will help veterinarians better diagnose and treat feline asthma. In addition to these results, this study provided extensive training to a postgraduate student and five veterinary students. For horses Insight could increase survival of sick foals Dr. Ramiro E. Toribio The Ohio State University Sepsis is the no. 1 cause of death in newborn foals. This life-threatening condition impairs several bodily functions, including energy metabolism. This study examined the levels of two important energy-regulating hormones, insulin and leptin, in foals with sepsis. With funding from Morris Animal Foundation, the researchers proved their hypothesis that these hormones are abnormal in foals with sepsis, and that the imbalances are associated with an increased risk of dying of sepsis. These results emphasize the importance of controlling the energy needs of critically ill foals. The results will help improve the treatment and prognosis for this deadly disease. For wildlife For wildlife For wildlife Parasite control improved in captive giraffes Better detection of chronic wasting disease Environment and stress affect cheetah health Dr. Gary West and Dr. Butch KuKanich Kansas State University Dr. Edward A. Hoover Colorado State University Dr. Karen A. Terio University of Illinois Captive giraffes are highly susceptible to parasitic infections that cause weight loss, lethargy and even death. Treatment to prevent parasites has caused some animals to develop resistance to medications, however. This resistance is likely due to improper dosing. The increasing incidence of resistance has limited the kinds of drugs caretakers can use to treat captive giraffes with intestinal parasites. Chronic wasting disease (CWD) is a fatal, contagious brain disease of cervids, including mule deer, elk and moose. It was originally found only in northern Colorado and southeastern Wyoming, but its range is spreading. Captive cheetah populations worldwide are plagued by debilitating diseases and infertility, conditions that are rare in wild cheetahs. Although these conditions were originally thought to be associated with the lack of genetic diversity in captive animals, mounting evidence indicates that chronic stress in response to aspects of the captive environment alters the cheetah’s immune system. Using Morris Animal Foundation funding, researchers from Kansas State University tested oral and topical formulations of an antiparasitic drug to determine which formulation is most effective. They found that although topical administration is easier, it is more variable and may promote drug resistance. Oral dosing produced the best therapeutic concentrations and appears to be the better dosing route to minimize the development of resistant parasites. With Morris Animal Foundation funding, researchers from Colorado State University have developed a test to detect low levels of the CWD agent in the blood and other body fluids of deer. This new method could help wildlife managers and veterinarians better identify CWD in deer and possibly in other species. The findings also have the potential to identify lifelong carrier animals. This work will benefit any species that may be exposed to CWD. Learn more Scientists from the University of Illinois investigated how individual animal temperament, environmental factors and captive management practices influence stress responses of cheetahs and affect the development of Helicobacter-induced gastritis, one of the more serious diseases affecting captive cheetahs. Through this Morris Animal Foundation–funded study, they found that cheetahs with certain temperaments are at high risk for detrimental stress responses and gastritis. They also learned that gastritis and stress hormone levels varied significantly by facility, indicating that overall facility management practices are important in controlling disease and stress response. In particular, housing animals with high-risk temperaments at certain facilities or improving facility designs to lower stress in these animals may be beneficial in improving the overall health of captive cheetahs. Want to learn more about the health issues that affect your pet? Morris Animal Foundation’s new online health info centers provide a wealth of information about various diseases that affect cats and dogs. Visit the For Pet Lovers section of the website, www.MorrisAnimalFoundation.org, to learn more. www.MorrisAnimalFoundation.org 11 Cancer campaign funds nearly $5 million in research in five years Five years ago, Morris Animal Foundation launched an initiative to increase our funding for studies that would tackle the no. 1 killer of dogs: cancer. At the time our objectives were simple. We wanted to give scientists genetic tools to study cancer, to help researchers test treatments and determine ways to prevent cancer and to train new canine cancer researchers. We knew cancer was a big concern for dog lovers, but we never anticipated the outpouring of support we received from thousands of people across the country. Thanks to their support, we pledged funding for more than 40 canine cancer studies—many of which are still under way— totaling more than $4.7 million. This campaign has been, without a doubt, an outstanding success. We would like to share some of the highlights of the past five years. Some campaign successes • Establishing a tumor tissue bank that houses samples of the most common canine cancers, which will help scientists study cancer and potential treatments • Funding two programs that train scientists to head research programs that will lead to new discoveries in the field of cancer for companion animals • Discovering genetic information that could lead to a prognostic lymphoma test • Identifying inherited deficiencies that may contribute to the development of lymphoma in Golden Retrievers • Developing dosing calculations that will help provide more effective and safer chemotherapy dosing, determining more effective ways to administer chemotherapy and finding evidence of how to overcome chemotherapy resistance • Identifying a promising inhibitor that may help kill bone cancer cells and a drug with potential for shrinking soft-tissue sarcomas • Raising awareness of canine cancer through the K9 Cancer Walk Program, which hosted 13 walks that involved more than 5,000 dog lovers and raised more than half a million dollars for canine cancer research It is thanks to your gifts that we have been able to make a significant difference in the lives of dogs with cancer. Though we will no longer use our Canine Cancer Campaign logo and website, Morris Animal Foundation remains dedicated to funding canine cancer studies. In fact, we’ve pledged nearly $5.5 million for more than 30 studies currently under way. We also recently launched the Canine Lifetime Health Project, a nationwide effort that involves groundbreaking studies designed to learn how to prevent and treat major diseases affecting dogs. The first study we’re funding addresses—you guessed it—cancer. We encourage you to visit www.CanineLifetimeHealth.org today to join the project. B 12 Your monthly gift makes a world of difference Become a loyal friend and your monthly gift will support science that truly makes a difference in the lives of animals. When you enroll in automatic monthly giving, you provide Morris Animal Foundation with ongoing, sustainable support for the programs that create a healthier tomorrow for animals. Even the smallest gifts add up quickly. Did you know that monthly giving is an easy and effective way to support Morris Animal Foundation? Monthly giving • Makes it easy to budget your charitable giving • Allows you to easily manage your donations through our online Service Center • Entitles you to receive our quarterly eNews and quarterly AnimalNews newsletter • Helps Morris Animal Foundation focus critical resources on advancing animal health worldwide Make your monthly giving commitment this spring. Simply visit the Donate section of our website, www.MorrisAnimalFoundation.org, and choose Monthly Giving to give a gift for all seasons. B Join us online Good things are happening every day at Morris Animal Foundation, and you can be part of our animal-loving community by joining us online. Simply “like” us on Facebook (www.facebook.com/morrisanimal), follow us on Twitter (www.twitter.com/morris_animal) or tune in to our YouTube channel (www.youtube.com/morrisanimal). Learn about how our funding makes animal health advances possible, read about or watch fun animal antics, share your passion for animals and tell us your thoughts on animal health. We also encourage you to share news about us with your animal-loving friends and family members. The more people working toward animal health advancements, the better off our pets will be. B www.MorrisAnimalFoundation.org 13 In loving memory At Morris Animal Foundation we know how difficult it is to lose a special pet. Pets are part of our families, and this section honors the amazing animals that have touched their families’ lives. The pets in this section were honored through qualifying donations made between December 16, 2011, and March 15, 2012. These gifts will be used to improve animal health by funding research that can help protect, treat and cure the animals of the future. Gifts of $200 or more per pet qualify a special pet to be listed in the “In loving memory” section of AnimalNews. Please send a photo for consideration with your donation. For donations of $500 or more, a brass plate engraved with your pet’s name will also be added to our Pet Memorial Wall. For more information, visit the Donate section on our website and click on Memorial and Honor Gifts. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 14 Abbie (1) Ellie (13) Max, Our Sunshine (21) Shadow (34) Abby (2) Elsa Maximus Decimus Meridius (Max) (22) Sinckers, Murphy & Charlie Beloved Great Dane DONOR: Dr. & Mrs. W. A. Deneke FAMILY: Bill, Sue, Emmy and all the kids and grandkids Beloved Pets DONOR: Linda McBain & George Waters FAMILY: Linda McBain & George Waters Maxine (23) Skylar Mio Sophie (35) Missy (24) Sprout (36) Hawkeye & Joker Missy (25) Storm & Rex (37) Irish Setters Mollie (26) Stuey (38) Molly Tara (39) Mugsy Malone (27) Thor Nattie (28) Toby (40) Pearl & Diamond (29) Truman (41) Pepper & Madison (30) Tucker Puk Tucker-B Robbie’s Fritzie, Robbie’s Penelope Katrina & Penny K. Wahl Vixen Beloved Best Friend D O NO R : Mark & Kathy Lowery FAMI LY : Mark & Kathy Lowery Beloved Dog D O NO R : Penny & Bill Carlson FAMI LY : Debby & Terry Fitch Abby (3) Beloved Best Friend D O NO R : Mike Nielson FAMI LY : Mike Nielson & Les Posey Alex Beloved Cat D O NO R : Elizabeth Cohen FAMI LY : Andy Ruland & Sue Sherwin Archie (4) Beloved Dog D O NO R : Penny & Bill Carlson FAMI LY : Jeanne Urna & Lino Legrottaglie Blossom Beloved Dog D O NO R : Mary Jo Scholand FAMI LY : Mary Jo Scholand Boomer (5) Beloved Dog D O NO R : Pamela & Arnold Loeb FAMI LY : Pamela & Arnold Loeb Bronwyn Beloved Dog D O NO R : Elizabeth & Erik Delfosse FAMI LY : Elizabeth & Erik Delfosse Butler (6) Beloved Dog D O NO R : Bob & Karen Jachens FAMI LY : Tish McGlynn & Jim Dixson Butterball Beloved Cat D O NO R : Elizabeth A. Biddick FAMI LY : Elizabeth A. Biddick Calin (7) Beloved Cat D O NO R : Veronique Delesalle FAMI LY : Veronique Delesalle Candi & Heather Beloved Smooth Collies D O NO R : Carol S. Martin FAMI LY : Carol S. Martin Charley (8) Beloved Dog D O NO R : Michael & Elizabeth Maroney FAMI LY : Susan & David Swain Charlie Girl (9) Beloved Best Dog and Friend D O NO R : John & Sandy Moss FAMI LY : John & Sandy Moss Chrissy (10) Beloved Cat D O NO R : Joseph A. Egrie FAMI LY : Joseph A. Egrie Chrissy (11) Beloved Poodle D O NO R : Dennis Snider FAMI LY : Dennis & Kristen Snider Dakota (12) Beloved Sweet Pea D O NO R : The Weir Family FAMI LY : Todd Bjella www.MorrisAnimalFoundation.org Beloved Companion DON OR: Anonymous FA M I LY: Carla Heiland Beloved Cat DON OR: Carolyn Edwards FA M I LY: Christine Patoff Freeway Beloved Dog DON OR: Denise Achram FA M I LY: Mr. & Mrs. Ken Mack Haley’s Peach Brandy Beloved Golden Retriever DON OR: Alonzo & Laura Rosado FA M I LY: Alonzo & Laura Rosado Hanna, Bosco & Maggie Beloved Dogs DON OR: Sacramento Valley Dog Fanciers Assocation FA M I LY: Sacramento Valley Dog Fanciers Assocation Beloved Pets DON OR: Mary O’Leary FA M I LY: Machelle & John O’Neill Beloved Companions No Longer with Us DON OR: Irish Setter Club of Colorado Inc. FA M I LY: Irish Setter Club of Colorado Inc. Jessie (14) Beloved Canine DON OR: Lynn Myers, VMD, & Irving Stein FA M I LY: Angela Butler & Ed Haare Jigsaw (15) Beloved Australian Cattle Dog DON OR: Anne Ruddy & Nancy Bertino FA M I LY: Tamara & Jim Fogelquist Kako (16) Beloved Cat DON OR: Hui Chau FA M I LY: The Chau Family Lily (17) Beloved Dog DON OR: Anne Pardee FA M I LY: Anne Pardee Loke Beloved Pet DON OR: Richard Rudman & Karen Greenberg FA M I LY: Darre Halloran Lonestar Sir Bubba Pantzalot Spruill (18) Beloved Most Loving & Gentle English Mastiff DON OR: Dottie Spruill FA M I LY: Frank & Dottie Spruill Mandy (19) Beloved Companion DON OR: Dave & Blanche Roberts FA M I LY: Dave & Blanche Roberts Manny (20) Beloved Cat DON OR: Joseph A. Egrie FA M I LY: Joseph A. Egrie Marla & Priss Beloved Pets DON OR: Douglas & Kathy Miller FA M I LY: Douglas & Kathy Miller Beloved Golden Retriever DONOR: Robert & Vicki Uhr FAMILY: Robert & Vicki Uhr Beloved Greyhound & Friend DONOR: Nancy Ann Shores FAMILY: Nancy Ann Shores Beloved German Shepherd DONOR: Kim Mason FAMILY: Kim Mason Beloved Toy Fox Terrier DONOR: Joanna Barnish FAMILY: The Barnish Family Beloved Cat DONOR: Jay & Marcia Newton FAMILY: Jay & Marcia Newton Beloved Dog DONOR: KT Torello & Linda Benedetti FAMILY: KT Torello & Linda Benedetti Beloved English Springer Spaniel DONOR: Shirley Thomas FAMILY: The David Newman Family Beloved Scottie DONOR: Sissy Dyer & Mike Clinton FAMILY: Sissy Dyer & Mike Clinton Beloved Cocker Spaniel DONOR: Linda & Marc Jarvis FAMILY: The Jarvis Family Beloved Greyhounds, Forever in My Heart DONOR: Mary Pat Parkhill FAMILY: Mary Pat Parkhill Beloved Miniature Schnauzers DONOR: Bill & Denise Jordan FAMILY: Bill & Denise Jordan Beloved Pet DONOR: Karrie Wright FAMILY: Gregg Wolf Beloved Dogs DONOR: Barbara J. Wahl FAMILY: Barbara J. Wahl Sadie (31) Beloved Dog DONOR: Catherine G. Ross FAMILY: Catherine G. Ross Schroeder (32) Beloved Pet DONOR: Walter & Judith Schirber FAMILY: Walter & Judith Schirber Beloved Pug DONOR: Ronald Yucas & John DeForge FAMILY: Ariuska & Phonzo Pearson Beloved Dog DONOR: Carol S. Martin FAMILY: Ed & Sandy Rutkowski Beloved West Highland White Terrier DONOR: Linda & Norm Shartzer FAMILY: Linda & Norm Shartzer Beloved Cat DONOR: Ashley & Michael Seymour FAMILY: Ashley & Michael Seymour Beloved Pets DONOR: Nancy Myers FAMILY: Nancy Myers Beloved Pet DONOR: Fran Sunseri FAMILY: Art & Sharon Stewart Beloved Irish Setter DONOR: Kathi Guerrant FAMILY: Susan Walker Beloved Pet DONOR: Kevin Nixon FAMILY: Kevin Nixon Beloved Border Collie DONOR: Katherine Wallace FAMILY: Katherine Wallace Beloved Friend & Companion DONOR: The Truman Collar Website FAMILY: Debby & Terry Fitch Beloved Dog DONOR: Mary Henning FAMILY: Mary Henning Beloved Dog DONOR: Mary Headley FAMILY: Mary Headley Beloved Canine DONOR: Claire Rolfs & Rick Koehler FAMILY: Rob & Andie Fetherston Walter (42) Beloved Rescued Shelter Dog DONOR: Pamela Green FAMILY: Pamela Green, Grover, Velvet and Fox Wiley (43) Beloved Beagle DONOR: Brenda Heaster & Keith Ritter FAMILY: Brenda Heaster & Keith Ritter Sgt. Benny Ardoir (33) Beloved Dog DONOR: Penny & Bill Carlson FAMILY: Ken & Pam Wicker 15 B y A le x J imene z Some people don’t just make a habit out of doing good deeds—they make it their life’s mission. At Morris Animal Foundation, we might also call these people Lamplighters. Diane Tanner is a perfect example. As a member of the Lamplighter Society, Diane is including Morris Animal Foundation in her estate plans. Her selfless choice will give more animals the opportunity to enjoy longer, healthier lives. But Diane didn’t decide to become a Lamplighter overnight. In fact, she can trace her commitment to Morris Animal Foundation all the way back to a youthful joy ride and a serendipitous encounter with a dog who changed her life. Diane impishly recounts how she had to stop for gas after being chased around town by the local boys, but she turns a bit serious as she recalls her unexpected encounter with the gas station owner’s ferocious-looking Doberman, Duke. “Duke came strolling across the lawn like some motorcycle rider with a pack of ciggies rolled up in his T-shirt sleeve,” she continues. “He walked right up to me, leaned on my leg, turned his head up to my eyes, and I swear, he said, ‘Hey baby, what’s your name?’” Diane was hooked and continued to visit Duke every day. A few years later, when he fathered puppies, Diane didn’t miss a beat and quickly adopted one. “I named her Ilsa,” Diane says. “And she was my entire life for the next 12-and-a-half years.” Photo courtesy of Diane Tanner Chance encounter leads to lifelong puppy love Losing her beloved Ilsa brought Diane Tanner in touch with the Foundation, and she’s supported our mission ever since. Sadly, on the night of Diane’s birthday many years ago, Ilsa lost a 9-week battle with cancer, passing away in Diane’s arms. It was terribly painful, but Diane remembers how much it meant when her veterinarian sent her a memorial card through Morris Animal Foundation, commemorating Ilsa’s life. This past year, Diane’s appreciation for Morris Animal Foundation grew even stronger when her late mother became attached to a copy of AnimalNews in the weeks leading up to her passing. The magazine’s cover featured two sweet kittens that Diane’s mother absolutely adored. Diane sees the magazine as a symbolic token of her mother’s love for animals. Diane’s mother passed away on Valentine’s Day, which she says is fitting because her mom had such a huge heart. “The more love she had, the more she gave away,” Diane says of her mom. “She taught me to love, as did Ilsa. Supporting Morris Animal Foundation is the perfect way to honor them both.” Now retired, Diane spends her time volunteering at several animal shelters and community outreach programs and tending to the local public gardens. She is also devoted to her greyhound, Fudgie Ripples. With such a huge heart and an unrivaled dedication to animals and the greater good, Diane is a superb embodiment of a Lamplighter, lighting the future of animal health. B Learn more Have you remembered Morris Animal Foundation in your estate plans, or are you thinking about doing so? Contact Amy Buchheit at [email protected] or 800.243.2345 for more information about how you can be involved in the Lamplighter Society! 16 Virtual view: thoughts from our Facebook fans Summer is just around the corner. We recently asked our Facebook fans to share how they plan to enjoy the warm, sunny days with their pets. Here are some of their responses • “Weekly Greyhound group walk along the American River.”—Janet Psik • “Dogs get more walks, horse gets more riding!”—Judy Dillon • “Bringing them to work with me on a regular basis and more barn trips.” —Colleen O’Dell • “Hiking and camping, perhaps. Maybe a 14er?”—Breann VanEpp • “Lots of running and swimming if I can get her in the water.”—Sue Skelly Evanoff Share your passion for animals with us at www.facebook.com/morrisanimal. S TA F F BOARD OF TRUSTEES BOARD OF TRUSTEES executive officers trustees emeriti David Haworth, President/CEO Wayne A. Jensen, Chief Scientific Officer Dan Reed, Executive Development Officer John Taylor, Chief Operating Officer Mark J. Carter, Chair (Evergreen, CO) Stanley M. Teeter, Vice Chair (Topeka, KS) Roger H. Bohart, Treasurer (Boulder, CO) Amy Hunkeler, Corporate Secretary (Lee’s Summit, MO) Deborah Davenport, Scientific Liaison (Lecompton, KS) Eve Anderson Patty Barnard G. Marvin Beeman Erik Bergishagen Lewis Berman R. Anthony Chamberlin Mrs. Robert V. Clark Jr. Robert Detterman Sue Ane Langdon Emrek Lester Fisher Murray Fowler animalnews editor Heidi Jeter, Director of Communications animalnews contributors Liz Devitt Amy Ettinger Alex Jimenez Kelley Weir For a full listing of Morris Animal Foundation staff, please visit the About Us section at www.MorrisAnimalFoundation.org. H O U R S & C O N TA C T I N F O Monday – Friday 8:00 a.m.– 4:30 p.m. Mountain Time TOLL-FREE 800.243.2345 P 303.790.2345 board members Prema Arasu (Pullman, WA) Jim Dickie (Boulder, CO) Robin A. Downing (Windsor, CO) Susan Giovengo (Mason, OH) James A. Kutsch Jr. (Morristown, NJ) Hugh B. Lewis (Vancouver, WA) Lon D. Lewis (Topeka, KS) Patrick O. Long (Corvallis, OR) Bette M. Morris (Topeka, KS) David R. Morris (Shawnee, KS) Judith Needham (Hunt Valley, MD) Janice Peterson (Ocean Park, WA) Dominic Travis (St. Paul, MN) Cheryl A. Wagner (Roswell, GA) Betty White (Los Angeles, CA) E [email protected] presidents emeriti 10200 East Girard Avenue Suite B430 Denver, Colorado 80231 www.MorrisAnimalFoundation.org Tom Sullivan Betty White Thank you to the generous animal lovers who sponsored studies featured in this issue at a level ranging from $3,000 per year to the full cost of the project: Anonymous George Sydney & Phyllis Redmond Miller Trust GREYLong Hill’s Pet Nutrition Kettering Family Foundation Lincoln State Cat Club Kathleen & Robert Mahoney Nick & Patti Mattera Orthopedic Foundation for Animals PetScreen Ltd. Cheryl Sedestrom twitter.com/morris_animal The Treehouse Fund Morris Animal Foundation has received the highest charity rating. Printed on recycled paper with soy-based inks. SPONSORS North American Falconers Association www.facebook.com/morrisanimal Please use the envelope inserted in this issue to provide updated information and to alert us of duplicate mailings. Thank you for helping us save postage costs. Richard Gebhardt Alan Kalter Arlene Klein Daniel Marsh Jr. Dayle Marsh Dennis Murphy Peter Rhulen Ken Rosenthal Mary Silkworth Neil & Sylvia Van Sloun, The Van Sloun Foundation Cheryl A. Wagner Our staff is unable to provide veterinary medical advice. The opinions of study investigators may not necessarily be those of your companion animal’s veterinarian. Materials, including photographs and artwork, in this publication may be reprinted only with the permission of Morris Animal Foundation. Please write or call to receive financial information or permission to reprint materials: Morris Animal Foundation, 10200 E. Girard Ave., Suite B430, Denver, Colorado 80231, or call us at 800.243.2345. Morris Animal Foundation is a nonprofit organization and is tax exempt under the Internal Revenue Service regulation 501(c)(3). Our audited financial statement and state registration information are available upon request. To remove your name from Morris Animal Foundation’s mailing list, send an e-mail to [email protected] or call us at 800.243.2345. PLEASE CALL YOUR VETERINARIAN TO ASK PET HEALTH QUESTIONS. ©2012 Morris Animal Foundation. All rights reserved. 17 10200 East Girard Avenue Suite B430 Denver, Colorado 80231 NONPROFIT ORG. U.S. POSTAGE PA ID *** *** MORRIS ANIMAL FOUNDATION Please use the envelope inserted in this issue to provide updated information and to alert us of duplicate mailings. Thank you for helping us save postage costs. Your Legacy Gift Lights the Way Have you made Morris Animal Foundation a beneficiary of any of the following? ✓ Your will ✓ Your trust ✓ Your securities ✓ Your life insurance ✓ Your qualified pension plan (401K, 403(b)(7), IRA, Keogh) If so, you are eligible to join our Lamplighter Society! See page 16 for more information. Your gift will advance animal health for years to come.