1. Kinase Inhibitors - wako

Transcription

1. Kinase Inhibitors
Wako Cat. No. Pkg. Size
Grade
CAS No.
Soluble in
IC50
Storage Condition
909910-43-6
DMSO
-
Keep at -20℃.
Summary
A-83-01 【TGF-β R I Kinase Inhibitor IV】
018-22521
2 mg
014-22523
10 mg
for Cellbiology
Product Name
<Protein kinase inhibitor>
Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7. Inhibits Smad2/3
phosphorylation and TGF-β-induced epithelial-to-mesenchymal transition. This product has little or no effect on bone morphogenetic protein
type I receptors, p38 MAP kinases, and extracellular-regulated kinases.
17-AAG, 97.0+ % (HPLC)
012-20101
1 mg
for Cellbiology
75747-14-7
DMSO, methanol
EC50 of HSP90 = 7.2 μM
Keep at -20℃.
<Protein kinase inhibitor/ protein tyrosine kinase (PTK) inhibitor>
Synthetic derivative of geldanamycin, which is one of the ansamycin antibiotics. 17-AAG inhibits the function of HSP90 by binding to the ATP
binding site of HSP90. HSP90 inhibitors dephosphorylate Akt resulting in inactivation of Akt and apoptosis.
AG 490, 95+% (TLC)
013-17181
5 mg
for Biochemistry
134036-52-5
DMSO, DMF,
methanol
IC50 of Dephosphorylation of EGF
receptor tyrosine kinase: 1.2 μmol;
EGF dependent cell proliferation: 6 μmol
Keep at -20℃.
<PTK inhibitor>
Specific and potent JAK-2 protein tyrosine kinase inhibitor. Also inhibits EGF receptor autophosphorylation.
AG 1296
016-20121
5 mg
for Cellbiology
146535-11-7
DMSO
-
Keep at -20℃.
<PTK inhibitor>
It inhibits signaling in human PDGF (platelet-derived growth factor) α receptor, PDGF β receptor, stem cell stimulating factor c-kit and FGF
(fibroblast growth factor) receptor.
AG 1478
017-20151
5 mg
for Cellbiology
175178-82-2
DMSO
-
Keep at -20℃.
<PTK inhibitor>
Potent and selective inhibitor of EGF receptor kinase. Decrease in EGF-stimulating DNA synthesis and inhibition of activation of EGFdependent src family kinase have been reported.
ALK5 Inhibitor, 96.0+ % (HPLC)
012-23021
1 mg
for Cellbiology
446859-33-2
methanol
-
Keep at -20℃.
Potent and selective ATP-competitive inhibitor of TGF-β RI kinase/ALK5. Can be used as substitute of Sox2 or c-Myc (Yamanaka 4 factors)
in induction of murine iPS cells.
Aminogenistein, 90.0+ % (HPLC)
017-15901
1 mg
for Biochemistry
132018-32-7
Ethanol, DMSO
IC50 of lck = 1.2 μM
Keep at -20℃.
<PTK inhibitor>
Inhibitor of PTK, especially p56lck. The product, even among other flavons, is able to specifically inhibit lck activity at a low dose and is
therefore employed as an useful tool for clarification of the mechanism of immune response activation.
Apigenin, 95+ % (TLC)
010-18914
5 mg
016-18911
10 mg
012-18913
50 mg
for Biochemistry
520-36-5
Methanol
-
Keep at 2-10℃.
<MAP kinase inhibitor>
Plant flavonoid. It changes phenotypes of many ras transformed cells to the original form. This is achieved by inhibition of signal transduction
route mediating MAP (Miogen Activated Protein) kinase (MAPK). In case of NIH3T3 cells transformed by v-H-ras, treatment with apigenin (12.5
μM) induces dephosphorylation of p44 MAPK resulting in a decrease in MAP kinase activity.
AS 604850, 98.0+ % (HPLC)
015-23131
5 mg
for Cellbiology
648449-76-7
DMSO
IC50 of PI3Kα: 4.5 μM; PI3Kγ: 250 nM;
PI3Kβ, PI3Kδ: 250 nM
Keep at 2 - 10℃
Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ. It exhibits highly selectivity.
1
Product Name
Grade
CAS No.
Soluble in
648450-29-7
DMSO
IC50
Storage Condition
Summary
AS 605240, 95.0+ % (HPLC)
012-23141
5 mg
for Cellbiology
IC50 of PI3Kα: 60 nM; PI3Kγ: 270 nM;
PI3Kβ: 8 nM; PI3Kδ: 300 nM
Keep at 2 - 10℃
Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ (Ki = 180 nM). It exhibits highly
selectivity.
ATM Kinase Inhibitor, 97.0+ % (HPLC)
015-22911
2 mg
for Cellbiology
587871-26-9
Ethanol
ATM: IC50 = 13 nM; Ki = 2.2 nM
Keep at -20℃.
<Cyclin-Dependent Kinase (CDK) Inhibitor>
Cell-permeable, ATP-competitive inhibitor of ATM kinase. Shows high ATM kinase selectivity for PIKK and PI3K family kinases.
6-Bromoindirubin-3'-oxime【BIO】
【GSK-3 Inhibitor IX】, 95.0+ % (HPLC)
029-16241
1 mg
for Cellbiology
667463-62-9
-
-
Keep at 2 - 10℃
Potent and reversible ATP-competitive inhibitor. It shows to activate the Wnt signaling pathway and maintain pluripotencies in human and
murine ES cells and also promotes cardiomyocyte proliferation and acts as a GSK-3 inhibitor.
Butein, 98.0+ % (HPLC)
027-14461
10 mg
for Biochemistry
487-52-5
Methanol, DMSO
-
Keep at -20℃.
<Protein tyrosine kinase (PTK) inhibitor>
Tyrosine kinase inhibitor isolated from plant polyphenols. Reported to activate SIrt1 (Class III HDAC).
Calphostin C, 95.0+ % (HPLC)
030-15133
50 μg
034-15131
100 μg
for Cellbiology
121263-19-2
DMSO, DMF
IC50 of PKC: 50 nM; HeLa S3: 0.23 μg/mL;
MCF-7: 0.18 μg/mL
Keep at 2-10℃.
<Protein kinase C (PKC) inhibitor>
Specific protein kinase C (PKC) inhibitor. Shows strong anticellular activity against a variety of cultured cells.
Carbonyl Cyanide m-Chlorophenylhydrazone, 97+% (TLC)
034-16993
100 mg
038-16991
1g
for Biochemistry
99534-03-9
Ethanol, acetone
-
Keep at -20℃.
-
Keep at -20℃.
Potent uncoupler of oxidative phosphorylation that inhibits mitochondrial function.
CKI-7 Dihydrochloride, 97.0+ % (HPLC)
034-21501
5 mg
for Cellbiology
-
Water
Casein kinase (CK1) inhibitor. Use with SB431542 and Y-27632 induces differentiation of human ES cells and human iPS cells into retinal
progenitor cells in serum- and feeder cell-free culture medium.
Compound 15e, 98.0+ % (HPLC)
031-21491
5 mg
for Cellbiology
371943-05-4
Ethanol
IC50 of PI3Kα: 2 nM; PI3Kβ: 16 nM;
PI3Kγ: 660 nM; PI3KC2β: 220 nM
Keep at 2 - 10℃
Permeable morpholino pyrimidine compound. A highly selective PI3Kα inhibitor.
Compound 401, 98.0+ % (HPLC)
033-21951
1 mg
039-21953
5 mg
for Cellbiology
168425-64-7
Methanol
IC50 of DNA-PK: 0.28 μM; mTOR: 5.3 μM;
ATM, ATR ＞ 100 μM
Keep at -20℃.
Reversible and selective DNA-PK and mTOR inhibitor. It exhibits negligible affinity to PI3K, ATM and ATR. It has been known to inhibit mTORdependent proliferation and induce apoptosis in TSC1-/- mouse embryo fibroblasts.
Deguelin
047-29211
5 mg
for Cellbiology
522-17-8
Acetone,
dichloromethane,
acetonitrile, DMSO
-
Keep at 2-10℃.
<Akt inhibitor>
Akt (Protein Kinase B; PKB) inhibitor. It inhibits proliferation of cells in the GM-2 stage of cell cycle. It induces apoptosis in the precancerous
and cancerated cell lines.
2
for other products, please visit the Wako Online Catalog www.e-reagent.com
Product Name
CAS No.
Grade
Soluble in
IC50
Storage Condition
Water, glacial acetic
acid, ethanol, acetone
and chloroform.
-
Keep at RT.
-
Keep at 2 - 10℃
Summary
Dibucaine Hydrochloride, 98.0+ % (after drying)(Titration)
049-20011
1g
for Biochemistry
61-12-1
Lipophilic PKC inhibitor. Inhibits Na+ and K+-ATPase activities, too.
Dorsomorphin, 99.6% (HPLC, the initiall lot)
045-31221
1 mg
041-31223
5 mg
for Cellbiology
866405-64-3
Methanol
Permeable pyrazolopyrimidine compound, which is potent, selective and reversible ATP-competitive inhibitor of AMPK (AMP-activated
protein kinasse). It has been shown to inhibit BMP signal strongly by inhibition of BMP type I receptors (ALK-2, ALK-3 and ALK- 6).
Dorsomorphin Dihydrochloride, 98.0+ % (HPLC)
047-31801
1 mg
043-31803
5 mg
for Cellbiology
1219168-18-9
Water
-
Keep at 2 - 10℃
This substance inhibits bone morphogenic factor (BMP) type I receptors (ALK2, ALK3 and ALK6). It has been shown to inhibit BMP signal
necessary for embryogenesis and accelerates important nerve differentiation from human pluripotential stem cells. It also functions as a
potent, selective and reversible ATP-competitive inhibitor of AMP-activating protein kinase (AMP-K).
Geldanamycin, from Streptomyces hygroscopicus, 95.0+ % (HPLC)
077-04571
100 μg
for Biochemistry
30562-34-6
Methanol
Keep at -20℃.
-
This product is an antitumor agent that has a benzoquinoid skeleton and has a pp60src tyrosine kynase inhibitory potency. Its
pharmacological action is more potent than that of herbimycin, which has a similar structure.
Genistein, 98.0+ % (HPLC)
073-05531
20 mg
079-05533
100 mg
for Cellbiology
446-72-0
Ethanol
-
Keep at -20℃.
Isoflavone compound. Tyrosine kinase inhibitor by antagonizing against ATP. Known to inhibit the proliferation of various solid tumor cells
and induce the differentiation of the tumor cells.
Genistin, from Soybean; 98.0+ % (HPLC)
070-04681
10 mg
076-04683
100 mg
for Biochemistry
529-59-9
Hot methanol
-
Keep at 2-10℃.
Soy extract isoflavone, or glucoside. Cancer-suppressing effects, antioxidant effects, and osteoporosis preventive effects have been
reported.
GF 109203X, 90.0+ % (HPLC)
079-03811
1 mg
for Cellbiology
133052-90-1
DMSO
IC50 of PKC: 10 nM
Keep at 2 - 10℃
<Protein kinase inhibitor / protein kinase C (PKC) inhibitor>
Potent and selective PKC inhibitor among bisindolylmaleimides, which have an inhibatory action on PKC. The structure is similar to that of
staurosporine.
Gö 6983
070-05801
1 mg
for Cellbiology
133053-19-7
DMSO
IC50 of PKCα: 7 nM; PKCβ: 7 nM; PKCγ: 6 nM;
PKCδ: 10 nM; PKCζ: 60 nM; PKCμ: 20μM
Keep at -20℃.
<Protein kinase C (PKC) inhibitor>
Cell-permeable PKC inhibitor
GSK 269962A, 97.0+ % (HPLC)
070-05921
2 mg
for Cellbiology
850664-21-0 DMSO, acetonitrile IC50 of ROCK-I: 1.6 nM; ROCK-II: 6 nM
Keep at 2 - 10℃
ROCK Inhibitor. Not available for sale in the USA due to patent.
3
Product Name
Grade
CAS No.
Soluble in
850664-21-0
Ethanol, DMSO,
water
IC50
Storage Condition
Summary
GSK 429286A, 97.0+ % (HPLC)
073-05911
2 mg
for Cellbiology
IC50 of ROCK: 14 nM
Keep at 2 - 10℃
ROCK inhibitor. It cancels out adrenaline-induced contraction of the aortic valve in rats and lowers the mean blood pressure in the arteries of
hypertensive rats.
H-1152 Dihydrochloride
088-09281
1 mg
for Cellbiology
871543-07-6
Water
IC50 of ROCK-II: 12 nM
Keep at -20℃.
ROCK inhibitor. Its inhibitory activity is more potent than that of Y-27632. It exhibits weak affinity to other serine/threonine kinases.
Herbimycin A, 98.0+ % (HPLC)
085-06491
1 mg
for Biochemistry
70563-58-5
Methanol, DMSO
-
Keep at 2-10℃.
Tyrosine kinase inhibitor by binding to the SH group of cysteine in oncogene src. It also inhibits transformation activity of oncogenes (src,
yes, fps, ros, abl, erbB) that have tyrosine kinase activity. It also has the unique ability to restore RSVts-NRK cells to their normal form.
Hypericin, from Hypericum perforatum
086-07761
1 mg
082-07763
5 mg
for Biochemistry
548-04-9
Water-THF
-
Keep at 2 - 10℃
<Protein kinase inhibitor / PKC inhibitor>
Inhibitor of PKC, insulin receptor, EGF receptor, casein kinase II, and thyrosine kinase activity of MAPK. It also exhibits antivirus and
antiretrovirus activities.
IPA-3, 97.0+ % (HPLC)
093-06231
5 mg
for Cellbiology
42521-82-4
DMSO, acetonitrile PAK1: IC50 = 2.5 μM
Keep at 2 - 10℃
p21 activation kinase (PAK) inhibitor, which binds to the regulatory domain of PAK and accelerates inactivation of PAKs structure. Shows
high selectivity to PAK1 in particular. PAK1 involves in tumor formation and metastasis.
K-252a
113-00561
50 μg
119-00563
100 μg
117-00564
250 μg
for Biochemistry
97161-97-2
Ethyl acetate
-
Keep at -20℃.
Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMPdependent protein kinase).
K-252b
110-00571
50 μg
114-00574
250 μg
for Biochemistry
99570-78-2
Methanol
-
Keep at -20℃.
Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMPdependent protein kinase).
Kenpaullone
110-00831
1 mg
116-00833
5 mg
for Cellbiology
142273-20-9
DMSO
-
Keep at -20℃.
<CDK Inhibitor>
Potent GSK-3β and CDK inhibitor. Inhibits antagonistically ATP binding. Reported to be substitutable for Klf4, one of the 4 Yamanaka
factors (Oct3/4, Klf4, Sox2, c-Myc), in iPS cell production. Also reported to improve reprogramming efficiency if added upon the introduction
of 4 Yamanaka factors.
Ki 8751, 96.0+ % (HPLC)
112-00891
5 mg
for Cellbiology
228559-41-9
DMSO
IC50 = 0.9 nM
Keep at -20℃.
Potent and selective VEGFR-2 tyrosine kinase inhibito.
4
Product Name
Grade
CAS No.
Soluble in
for Biochemistry
127191-97-3
Methanol, DMSO
IC50
Storage Condition
Summary
KN-62
118-00631
1 mg
114-00633
5 mg
Ca2+ / calmodulin-dependent protein
kinase II (in rat brain): IC50 = 0.3 μM
Keep at 2-10℃.
<Kinase inhibitor / Calmodulin antagonist>
Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. It inhibits the proliferation of K562 cells (1 μM).
KN-93
115-00641
1 mg
111-00643
5 mg
for Biochemistry
139298-40-1
Methanol
Ca2+ / calmodulin-dependent protein
kinase II (in rat brain): IC50 = 2.0 μM
Keep at 2-10℃.
<PKC inhibitor / Calmodulin antagonist>
Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans
caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.
KN-93, Water-Soluble
114-00731
1 mg
for Cellbiology
-
Water
-
Keep at -20℃.
<PKC inhibitor>
Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans
caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.
KT 5720
117-00581
50 μg
113-00583
100 μg
111-00584
250 μg
for Biochemistry
108068-98-0
Methanol
-
Keep at -20℃.
-
Keep at -20℃.
K252a derivative and membrane permeable PKA (cyclic AMP-dependent protein kinase) inhibitor
KT 5823
114-00591
50 μg
110-00593
100 μg
118-00594
250 μg
for Biochemistry
126643-37-6
Ethyl acetate,
methanol
<PKC inhibitor>
Cell-permeable PKC inhibitor
KU 0063794, 98.0+ % (HPLC)
115-00881
5 mg
for Cellbiology
938440-64-3
Acetone,
dichloromethane, IC50 of mTOR1: 10 nM; mTOR2: 10 nM.
acetonitrile, DMSO
Keep at 2-10℃.
<Akt inhibitor>
Selective mTOR (mammalian target of rapamycin) inhibitor. Shows no inhibitory activity against 76 types of protein kinases including PI3K
even at 1,000-fold concentration.
LDN 193189 Hydrochloride, 98.0+ % (HPLC)
124-06011
2 mg
for Cellbiology
1062368-62-0
Water
IC50 of ALK2: 5 nM; ALK3: 30 nM.
Keep at 2 - 10℃
This product inhibits ALK2 and ALK3, which are BMP type I receptors, and consequently inhibits phosphorylation of Smad1, Smad5 and
Smad8.
LY 294002, 97.0+%（HPLC)
129-04861
5 mg
125-04863
10 mg
123-04864
25 mg
for Biochemistry
154447-36-6
Ethanol, acetone
IC50 of PI3-kinase: 1.4 μM;
Histamine secretion by PBL-2H3: 5 μM.
Keep at 2-10℃.
<Akt inhibitor>
Highly cell-permeable, specific phosphatidylinositol 3-kinase (PI3-kinase) inhibitor. It inhibits the proliferation of rabbit aorta smooth muscle
cells without inducing apoptosis. It is also reported to inhibit histamine secretion by RBL-2H3 cells.
5
Product Name
Grade/Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
Summary
Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Tyr
331-43741
0.5 mg
Peptide Institute
(4374-v)
-
Water
5142-23-4
-
Keep at -20℃.
IC50 = 4.1 nM
Inhibitor of calmodulin-dependent protein kinase II.
3-Methyladenine
131-17671
100 mg
137-17673
1g
for Biochemistry
-
Keep at -20℃.
<PI3 kinase inhibitor>
This product prevents downstream mTOR kinase activity degradation by inhibition of PI3-kinase , which in turn suppresses autophagy.
NSC 693868, 98.0+ % (HPLC)
140-08891
5 mg
for Cellbiology
40254-90-8
DMSO
-
Keep at 2 - 10℃
154447-35-5
DMSO
IC50 of DNA-PK: 0.23 μM; PI3K: 13.0 μM;
ATM, ATR ＞100 μM
Keep at 2 - 10℃
Selective inhibitor of GSK-3β and CDK5.
NU 7026, 97.0+ %
145-08841
5 mg
for Cellbiology
ATP-competitive inhibitor of the protein kinase DNA-PK (DNA-dependent protein kinase).
NU 7441, 98.0+ % (HPLC)
143-09001
1 mg
149-09003
5 mg
for Cellbiology
503468-95-9
Methanol
IC50 of DNA-PK: 14 μM; mTOR: 1.7 μM;
PI3K: 13.0 μM; ATM, ATR ＞100 μM
Keep at -20℃.
Potent, reversible and selective inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR. Has little affinity with PI3K, ATM, and ATR.
Known to inhibit mTOR-dependent proliferation and induce apoptosis in TSC1-/- mouse embryonic fibroblasts.
Olomoucine, 97+ % (TLC)
157-01901
5 mg
for Biochemistry
101622-51-9
DMSO
-
Keep at -20℃.
<CDK Inhibitor / MAPK inhibitor>
It inhibits p34cdc/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, cerebral p33cdk5/p35 and erk1/MAPK, and it has been reported to inhibit in vitro the
transition of the G2/M phase in the oocytes of starfish, and the transition of the G1/S phase in the mesophyll protoplasts of petunia.
PD-98059, 95+ % (TLC)
169-19211
5 mg
for Biochemistry
167869-21-8
Ethanol, acetone
-
Keep at -20℃.
<Protein kinase inhibitor/ MAPK inhibitor>
MAPK-1 inhibitor. This product has been reported to inhibit MAPK activation by insulin and block completely the increase in cell growth and
MAP activity induced by leptin (obesity regulating hormone). The resting cell pretreated with PD-98059 has been demonstrated to inhibit a
great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent.
PD 173074
166-24351
5 mg
for Cellbiology
219580-11-7
Methanol
- Keep at 2-10℃.
<PTK inhibitor>
ATP competitive type FGF receptor inhibitor. The FGF signaling pathway is associated with spontaneous proliferation of stem cells in a host
of systems.
PD 184352, 98.0+ % (HPLC)
169-25181
5 mg
for Cellbiology
212631-79-3
Methanol, DMSO
-
Keep at 2-10℃.
<MAPK Inhibitor>
Poteent and selective inhibitor of MEK1. Recent studies showed that culturing ES cells in a medium containing CHIR99021, SU5402,
PD184352 allows for highly-efficient suppression of differentiation.
6
Product Name
Grade
CAS No.
Soluble in
for Cellbiology
391210-10-9
Methanol, DMSO
IC50
Storage Condition
Summary
PD 0325901
162-25291
5 mg
168-25293
25 mg
IC50 of MEK: 0.33 nM
Keep at -20℃.
<MAPK Inhibitor>
MAPK inhibitor with potent antitumor activity. It induces phosphorylation of MAPK, inhibition of its activation and inhibition of tumor cell
proliferation. PD0325901 inhibits MAPK activity without adverse reactions. Addition of this product and CHIR99021 to a culture medium
results in efficient culture of mouse ES cells.
Phloretin, 98.0+ % (HPLC)
160-17781
250 mg
for Biochemistry
60-82-2
Methanol
IC50 = 16 μM
Keep at 2 - 10℃
<PKC inhibitor>
The aglycone moiety of phlorizin, a specific inhibitor of the sugar active transport system, which is actually responsible for the inhibitory
action of phlorizin.
When used alone, phloretin has been reported to be less effective for the active transport system while it is known to be more inhibitory than
phlorizin to the carrier transport system, suggesting a difference in the mode of action according to structure.
It is also useful as means for the study of the kinetics and regulatory mechanisms of PKC as a non-specific inhibitor of PKC.
PI-103, 98.0+ % (HPLC)
163-24241
1 mg
169-24243
10 mg
for Cellbiology
371935-74-9
DMSO
-
Keep at -20℃.
<Akt inhibitor>
Potent, cell-permeable and ATP-competitive inhibitor of DNA-PK, PI-3K, and mTOR with selectivity for a wide range of lipids and protein
kinases. Reported to inhibit PIP3 production, insulin signal transduction, and Akt phosphorylation, suppress cell proliferation, and induce cell
death.
Piceatannol
169-21661
10 mg
for Cellbiology
10083-24-6
Ethanol
-
Keep at 2 - 10℃
<Protein kinase inhibitor / PTK inhibitor>
Selective inhibitor of non-reception type tyrosine kinase Syk. An activator of human deacetylase class III (SIrt1).
PIK-75 Hydrochloride, 98.0+ % (HPLC)
162-24451
5 mg
for Cellbiology
-
Water-methanol
IC50 of PI3Kα: 0.3 nM; PI3Kβ: 850 nM;
PI3Kγ: 40 nM; PI3K C2β: 100 nM
Keep at 2 - 10℃
Cell-permeable imidazopyridine compound, which is a selective inhibitor of PI3Kα.
PKC 412, 96.0+ % (HPLC)
164-25751
1 mg
160-25753
10 mg
for Cellbiology
120685-11-2
-
-
Keep at -20℃.
Wide range of kinase inhibitor. Inhibits PKC, PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1,EGFR, etc.
PP 2, 94.0+ % (HPLC) 166-20331
1 mg
for Biochemistry
172889-27-9
Methanol, DMSO
-
Keep at -20℃.
5334-30-5
Methanol
-
Keep at -20℃.
1092351-67-1
DMSO
IC50 of mTOR: 8 nM; PI3Kα: 2 μM; PI3Kβ:
2.2 μM; PI3Kγ: 1.3 μM; PI3Kδ: 0.1 μM
Keep at 2-10℃.
<PTK inhibitor>
Src family tyrosine kinase inhibitor.
PP 3, 94.0+ % (HPLC)
163-20341
1 mg
for Biochemistry
<PTK inhibitor>
EGF receptor type tyrosine kinase inhibitor
PP 242, 98.0+ % (HPLC)
165-24441
5 mg
for Cellbiology
<Akt inhibitor>
Potent and selective mTOR (mammalian target of rapamycin) inhibitor
7
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Practical Grade
6151-25-3
Ethanol, acetone
-
Keep at RT.
Summary
Quercetin Dihydrate
171-00404
100 mg
177-00401
1g
173-00403
10 g
<Akt inhibitor>
Yellow flavonoid. Has antioxidant and anti-tumor effects. Its fat absorption inhibitory effect is particularly strong compared with other
polyphenols, and it aids in eliminating the body fat. Boosts the fat metabolism in the liver, increases fat combustion, and inhibits fat
absorption by binding to fat in the digestive tract. Also said to reduce the inflammation in pollinosis.
Rac1 Inhibitor, 98.0+ % (HPLC)
180-02491
5 mg
for Cellbiology
-
Water
-
Keep at 2-10℃.
<MAPK Inhibitor>
Selective inhibitor of Rac1-GEF interaction. Specifically inhibits Rac1 activity by inhibiting the interactions between Rac1 and Rac-specific
GEFs (guanine nucleotide exchange factors), TrioN and Tiam1.
Radicicol, 97.0+ % (HPLC)
183-01901
1 mg
for Cellbiology
12772-57-5
Ethanol, methanol,
DMSO
-
Keep at -20℃.
<PTK inhibitor>
Macrocyclic lactone antifungal antibiotic with antimalarial activity. It inhibits a heat shock protein 90 (HSP90) and protein tyrosine kinase.
Rapamycin (mixture of isomers)
184-02531
1 mg
180-02533
10 mg
188-02534
50 mg
for Cellbiology
53123-88-9
-
-
Keep at -20℃.
Macrolide immunosuppressive agent. A structural analog of FK506 that binds to FK506 binding proteins (FKBPs) but does not inhibit
calcineurin activity. The rapamycin-FKBP complex inhibits the signal from IL-2 by inhibiting the kinase activity of mTOR. Inhibits G1-to-S
phase transition of the cell cycle.
RG-14620
188-02811
10 mg
184-02813
50 mg
for Cellbiology
136831-49-7
-
138489-18-6
Ethanol
IC50 = 3μM
Keep at -20℃.
IC50 of PKCα: 5 nM; PKCβI: 24 nM;
PKCβII: 14 nM; PKCγ: 27 nM; PKCε: 24 nM;
PKA: 0.9 μM; CaM kinase II: 17 μM
Keep at 2-10℃.
EGFR tyrosine kinase inhibitor
Ro 31-8220 Methanesulfonate
186-02591
1 mg
for Cellbiology
<PKC inhibitor>
A structural analog of staurosporine. Potent, cell-permeable PKC inhibitor. Its selectivity for PKAs and CaM kinase II is low, and it also has
inhibiting effects on glycogen synthase kinase 3 (GSK3) and voltage-dependent Na channels.
Roscovitine, 98.0+ % (HPLC)
182-01591
1 mg
188-01593
10 mg
for Biochemistry
186692-46-6
DMSO, ethanol,
acetone
-
Keep at -20℃.
<CDK inhibitor>
Olomoucine analog and CDK2 and CDK5 inhibitor. In Alzheimer's disease, it is believed to be associated with hyperphosphorylated tau.
SB 202190
193-13531
1 mg
for Cellbiology
152121-30-7
Methanol
-
Keep at -20℃.
<MAPK Inhibitor>
Potent and selective inhibitor of the p38α and β isoforms of p38 MAPK family. Shows membrane permeability. It has no effect on ERK and
JNK MAPK.
8
Product Name
Grade
CAS No.
Soluble in
152121-47-6
DMSO, methanol
IC50
Storage Condition
Summary
SB 203580, 98.0+ % (HPLC)
199-16551
1 mg
195-16553
10 mg
for Cellbiology
IC50 of SAPK2a / p38: 50 nM;
SAPK2b / p38β2: 50 nM
Keep at -20℃.
<Protein kinase inhibitor / MAPK inhibitor>
Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).
SB 203580 Hydrochloride, 98.0+ % (HPLC)
198-16761
1 mg
for Cellbiology
869185-85-3
Water
IC50 of p38α (in vitro): 34 nM;
(in vivo): 600 nM
Keep at -20℃.
<MAPK Inhibitor>
Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).
SB 415286, 98.0+ % (HPLC)
197-15751
5 mg
for Cellbiology
264218-23-7
DMSO
-
Keep at -20℃.
Potent, cell-permeable, and selective GSK-3 inhibitor. GSK-3β inhibitors are used in a variety of stem cell research including ES cells and
iPS cells. Reduces the cell death of cerebellar granule neurons in vivo. Also increases cytoplasmic β-catenin concentration and inhibits
GSK-3-dependent tau phosphorylation. Also reported to stimulate glycogen synthesis and gene transcription and have protective effects on
the heart and nerves.
SB 431542, 98.0+ % (HPLC)
192-16541
5 mg
198-16543
25 mg
for Cell Culture
331752-47-7
DMSO
Keep at -20℃.
IC50 of ALK = 7 nM
Selective inhibitor of activin receptor-like kinase (ALK) 4, 5 and 7 (the TGF-β type I receptor).
Promotes proliferation, differentiation and sheet formation of endothelial cells of ES cell origin. Can be able to grow dramatically efficiency
reprogramming to Human iPS Cells when used with Thiazovivin and PD0325901. It also promotes the speed.
SP 600125, 98.0+ % (HPLC)
197-16591
5 mg
193-16593
25 mg
for Cellbiology
129-56-6
Acetone, DMSO
IC50 of JNK1: 40 nM; JNK2: 40 nM;
JNK3: 90 nM
Keep at -20℃.
MAPK inhibitor and potent ATP-competitive inhibitor of the c-Jun N-terminal kinase (JNK) subfamily.
Its selectivity to JNK exceeds 20 times that of ERK and p38 MAPK. It inhibits c-Jun phosphorylation and the expression of inflammatory
genes such as COX-2, LI-2, IFN-γ, and TNF-α. It is neuroprotective in vivo.
D-erythro-Sphingosine, 99+% (TLC)
192-11161
25 mg
for Biochemistry
123-78-4
MethanolIC50 of PKC: 1 - 3 μM
chloroform mixture
Keep at -20℃.
<Protein kinase inhibitor / PTK inhibitor>
Selective PKC inhibitot. It exhibit inhibitory action competitively to diacylglycerol, phorbol dibutyrate and Ca2+. It does not affect the
activities of MLCK and PKA. It has also been reported to induce apoptosis in human myelocytic leukemia cells, HL-60.
SR 3677 Hydrochloride, 98.0+ % (HPLC)
195-16151
2 mg
for Cellbiology
1072959-67-1
Water, DMSO
IC50 of ROCK-I: 56 nM, ROCK-II: 3 nM
Keep at RT.
62996-74-1
DMSO
IC50 of PKC: 2.7 nM; PKA: 8.2 nM;
p60v-src tyrosine kinase: 6.4 nM
Keep at -20℃.
Potent ROCK inhibitor
Staurosporine, 95.0+ % (HPLC)
197-10251
100 μg
193-10253
500 μg
for Biochemistry
<PKC inhibitor / CDK inhibitor>
A microbial alkaloid and extremely potent inhibitor of protein kinase Cs (PKCs). Also has comparable inhibitory actions on cAMP-dependent
protein kinases (PKAs) and p60v-src tyrosine kinase, the product of an oncogene src.
Stellettamide A Triﬂuoroacetate, 95.0+ % (HPLC)
193-11831
100 μg
for Biochemistry
129744-24-7
Methanol
-
Keep at -20℃.
<PKC inhibitor>
Substance isolated and extracted from sponge (Stelletta sponge). It inhibits calmodulin.
9
Product Name
Grade
CAS No.
Soluble in
for Cellbiology
-
Ethanol
IC50
Storage Condition
Summary
SU 4312, 97.0+ % (HPLC)
190-15861
5 mg
Ki: unactivated form: 0.04 μM;
activated form: 4 μM
Keep at -20℃.
<Protein kinase inhibitor / Akt inhibitor>
VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.
SU 5402, 95.0+ % (HPLC)
193-16071
1 mg
for Cellbiology
215543-92-3
DMSO
-
Keep at -20℃.
<PTK inhibitor>
Tyrosine kinase inhibitor in fibroblast growth factor receptor 1 (FGFR1). It also inhibits phosphorylation of ERK1 and ERK2 induced by aFGF.
A recent study has demonstrated inhibition of differentiation at a high efficiency by incubating ES cells in a medium containing CHIR99021,
SU5402 and PD184352.
SU 5416, 97.0+ % (HPLC)
196-15841
5 mg
for Cellbiology
204005-46-9
Ethanol
IC50 of VEGFR2: 1.3 μM; FGFR1: 4.2 μM;
PDGFRβ: 37.9 μM
Keep at -20℃.
<Protein kinase inhibitor / Akt inhibitor>
VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.
SU 6668, 98.0+ % (HPLC)
193-15851
5 mg
for Cellbiology
252916-29-3
Ethanol
IC50 of VEGFR2: 3.9 μM; FGFR1: 3.8 μM;
PDGFRβ: 0.10 μM
Keep at 2 - 10℃
658084-23-2
-
IC50 of c-MET tyrosine kinase: 10 nM;
VEGFR1/2 tyrosine kinase: 0.8 mM;
PDGFR: 19.4 mM
Keep at -20℃.
54965-24-1
Ethanol
IC50 of PKC: 2.7 nM; PKA: 8.2 nM;
p60v-src tyrosine kinase: 6.4 nM
Keep at 2-10℃.
VEGFR2 tyrosine kinase inhibitor
SU 11274, 95.0+ % (HPLC)
198-17121
5 mg
for Cellbiology
194-17123
25 mg
Selective inhibitor of c-MET tyrosine kinase.
Tamoxifen Citrate, 98.0+ % (Ti)
209-14361
250 mg
205-14363
1g
203-14364
5g
207-14362
25 g
for Biochemistry
<PKC inhibitor>
Estrogen analog, which is used as a drug used for prophylactic therapy of breast cancer, is known to selectively bind to estrogen receptors
and is also called SERM (selective estrogen receptor modifier). It is considered to be deeply associated with diseases such as breast cancer
and osteoporosis.
Triciribine, 95.0+ % (HPLC)
206-19371
5 mg
for Cellbiology
35943-35-2
-
IC50 of AKT kinase: 150 nM
Keep at -20℃.
Triciribine is inhibitor of AKT1/2/3 kinase and DNA synthesis inhibitor.
TWS 119, 90.0+ % (HPLC)
206-17671
1 mg
202-17673
5 mg
for Cellbiology
601514-19-6
Methanol
-
Keep at 2 - 10℃
Acts as a potent and selective inhibitor of GSK-3β. Also reported to selectively induce neuronal differentiation in murine embryonic stem
cells.
Tyrphostin A25, 95.0+ % (HPLC)
204-19311
10 mg
200-19313
50 mg
for Cellbiology
118409-58-8
-
IC50: 3 μM
Keep at -20℃.
EGFR tyrosine kinase inhibitor
10
Product Name
CAS No.
Soluble in
IC50
Storage Condition
109511-58-2
Acetonitrile, ethanol
-
Keep at -20℃.
Grade
Summary
U 0126 (mixture of isomers), 95.0+ % (HPLC)
211-01051
5 mg
for Biochemistry
MAPK inhibitor used for signal transduction studies.
W-5 Hydrochloride
236-01721
5 mg
232-01723
25 mg
for Biochemistry
61714-25-8
Methanol, water
IC50 of PDE: 240 μM; MLCK: 230 μM
Keep at -20℃.
<PKC inhibitor / Calmodulin antagonist>
A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase (PDE) and myosin light chain
kinase (MLCK). However, compared to W-7, its action as a calmodulin antagonist is low, and the product is mainly used as a negative
control of W-7.
W-7 Hydrochloride
233-01731
5 mg
239-01733
50 mg
237-01734
250 mg
for Biochemistry
61714-27-0
Methanol, water
IC50 of PDE: 28 μM; MLCK: 51 μM
Keep at -20℃.
<Protein kinase inhibitor / Calmodulin antagonist>
A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase and myosin light chain kinase.
(+)-Wortmannin, 97.0+ % (HPLC)
230-02341
2 mg
236-02343
10 mg
for Cellbiology
19545-26-7
Ethanol
-
Keep at -20℃.
<Akt inhibitor>
Has selective and irreversible inhibitory actions on myosin light chain kinases, a type of protein kinase that regulates smooth muscle
contraction etc., and concentration-dependent and irreversible inhibitory actions on phosphatidylinositol 3-kinases, which are involved in
phosphatidylinositol metabolism, one of the intracellular signal transduction mechanisms.
Y-27632, 98.0+ % (HPLC)
257-00511
1 mg
253-00513
5 mg
251-00514
25 mg
for Cellbiology
146986-50-7
Water
p160ROCK (Ki = 140 nM)
Keep at -20℃.
Selective and potent ROCK inhibitor. It inhibits contraction of the vascular smooth muscle, infiltration of cancer cells, and regulation of cell
differentiation caused by a signal transduction system of ROCK. Enhances survival rate after cryopreservation and cloning efficiency of
human ES and iPS cells.
5 mmol/L Y-27632 Solution
253-00591
300 μL
for Cell Culture
331752-47-7
-
-
Keep at -20℃.
5 mmol/L Y-27632 in aqueous soution.
11
2. Protein Phosphatase Inhibitors
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Summary
2. Protein Phosphatase
Inhibitors
Calyculin A, 95.0+ % (HPLC)
038-14453
10 μg
032-14451
100 μg
for Biochemistry
101932-71-2
Methanol, ethanol, IC of PP2A: 3 nM; smooth muscle: 5 nM;
DMSO
smooth muscle endogenous: 1 nM
Keep at -20℃.
Contracts the smooth muscle regardless of the presence of external calcium, with its effects being approximately 100 times more potent
than okadaic acid. A variety of actions have been confirmed, such as equally-potent inhibition of type 1 and 2A phosphatase activities and
promotion of protein phosphorylation.
Cantharidin
036-20461
25 mg
032-20463
100 mg
030-20464
500 mg
for Cellbiology
56-25-7
Acetone
IC50 of PP2A: 40 nM; PPA: 473 nM
Keep at 2-10℃.
Potent and selective protein phosphatase 2A inhibitor. Also inhibits protein phosphatase 1 at high concentrations.
Cyclosporin A, 97.0+ % (HPLC)
031-18963
50 mg
035-18961
200 mg
for Cellbiology
59865-13-3
Methanol, ethanol,
acetone, ether,
chloroform
-
Keep at 2-10℃.
It is a representative immunosuppressant used for prevention of rejection reaction at the time of organ transplantation and it binds to the
intracellular receptor in T lymphocytes inhibiting IL-2 and IFN-γ transcription (calcineurin inhibition). Consequently, it inhibits activation and
proliferation of helper T cells contributing to immune reaction.
Fostriecin Sodium Salt
065-05051
10 μg
for Cellbiology
87860-39-7
Ethanol, water
IC50 of PP1: 131 nM; PP2A: 3.2 nM
Keep at -20℃.
An antibiotic with anti-tumor activity isolated from Streptomyces pulveraceous (subspecies fostreus). Binds near the active center of the
catalytic subunit of PP2A and inhibits substrate dephosphorylation. Does not affect PP2B enzyme activity but shows inhibitory action on
PP1 as well at high concentrations.
RK-682, 95.0+ % (HPLC)
185-01341
1 mg
for Biochemistry
-
Ethanol, acetone
IC50 of CD45: 54 μM; VHR: 2.0 μM
Keep at RT.
Specific tyrosine phosphatase inhibitor, which inhibits dephosphorylation of CD45 or VHR, protein-tyrosine phosphatase (PTPase), and
regulates the cell cycle from G1 to S period.
Tautomycin
209-12041
100 μg
for Biochemistry
109946-35-2
Chloroform,
ethanol, methanol
IC50 of PP2A, PP1 (smooth muscle):
32 nM; PP1 (skeletal muscle): 22 nM;
Smooth muscle endofenous: 6 nM
Keep at -20℃.
Protein phosphatase inhibitor and antifungal antibiotic produced from Streptomyces spiroverticillatus.
Disodium β-Glycerophosphate Pentahydrate, 95.0+ % (Titration)
046-31251
50 g
042-31253
250 g
for Cellbiology
13408-09-8
Water: 1 g/20 mL
-
Keep at 2-10℃.
Has a structure of phosphorylated glycerol and in animal tissues is released into the blood with the breakdown of triglycerides in the liver.
Also produced as a glycolytic intermediate.
Levamisole Hydrochloride, 98.0+ % (Titration)
123-04641
10 g
for Biochemistry
16595-80-5
Water: 210 g/L
(20℃)
-
Keep at RT.
Powder type of alkaline phosphatase inhibitor. It promotes the maturation of T lymphocytes and increases cellular immune responses.
12
3. Inhibitor Cocktail Sets
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
-
-
Keep at 2-10℃.
Summary
Phosphatase Inhibitor Cocktail Solution I (×100)
167-24381
1 mL
for Cellbiology
-
5 phosphatase inhibitor mixture [Inhibition Target] serine/threonine phosphatases, tyrosine phosphatases, and dual-specificity phosphatases
[Composition] sodium fluoride, sodium orthovanadate, sodium pyrophosphate, β-glycerophosphate, and sodium molybdate
Phosphatase Inhibitor Cocktail Solution II (×100)
160-24371
1 mL
for Cellbiology
-
-
-
Keep at 2-10℃.
5 phosphatase inhibitor mixture [Inhibition Target] acid phosphatases; alkaline phosphatases; tyrosine phosphatases
[Composition] sodium fluoride, sodium tartrate, sodium orthovanadate, imidazole, and sodium molybdate
Protease Inhibitor Cocktail Set I, Animal-derived-free (for general use) (x 100), Lyophilized
for 1 mL
161-26023
for 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
5 inhibitor mixture solution. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products.
[Inhibition Target] a wide variety of proteases and esterases.
Protease Inhibitor Cocktail Set III, DMSO Solution (EDTA free) (x 100)
163-26061 1 mL
169-26063 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
3. Inhibitor Cocktail Sets
165-26021
6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and
bacterial extracts. It does not contain EDTA or other metalloproteinase inhibitors.
[Inhibition Target] a wide range of proteases including aminopeptidases.
Protease Inhibitor Cocktail Set III, DMSO Solution, Animal-derived-free (EDTA free) (×100)
160-26071 1 mL
166-26073 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and
bacterial extracts. It inhibits a wide range of proteases including aminopeptidases. It does not contain EDTA or other metalloproteinase
inhibitors. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products.
Protease Inhibitor Cocktail Set IV, DMSO Solution (for Fungal and Yeast) (×100)
167-26081 1 mL
163-26083 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
-
Keep at -20℃.
4 inhibitor mixture DMSO solution, being suitable for use in mold and yeast extracts.
[Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.
Protease Inhibitor Cocktail Set V (EDTA free) (×100), Lyophilized
162-26031
for 1 mL
168-26033
for 1 mL x 5
for Cellbiology
-
-
4 inhibitor mixture solution, being suitable for experiments targeted on metal-binding proteins and recombinant proteins.
In addition, also useful for metal-affinity column chromatography.
[Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.
Protease Inhibitor Cocktail Set VI, DMSO Solution (for Plant) (×100)
164-26091 1 mL
160-26093 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
6 inhibitor mixture solution, being suitable for plant extracts.
[Inhibition Target] serin proteases, cystein proteases, trypsin-like proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases,
metalloproteases.
Protease Inhibitor Cocktail Set VII, DMSO Solution (for Histidine-tagged Protein) (× 100)
167-26101 1 mL
163-26103 1 mL x 5
for Cellbiology
-
-
-
Keep at -20℃.
EDTA-free 5 inhibitor mixture solution, being suitable for purification of histidine-tagged proteins.
[Inhibition Target] serin proteases, cystein proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases, metalloproteases.
13
4. Calcium Signaling related Inhibitors
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Summary
Alendronate Sodium Salt Trihydrate, 97.0+ % (HPLC)
012-22661
100 mg
018-22663
500 mg
for Pharmacology
Research
121268-17-5
Water
IC50 = 10 μM
Keep at -20℃.
<Calcium metabolism regulator>
This product is a bisphosphonate compound that is selectively distributed in the calcified bone surface to which the osteoclasts are attached.
It is released under an acid environment created by the osteoclasts, taken in the cells, and inhibits the bone resorption activity. The inhibition
of the bone resorption is considered to be caused by apoptosis induction effect of the osteoclasts and direct suppression of bone resorption
of the osteoclasts.
(-)-Blebbistatin, 98.0+ % (HPLC)
021-17041
1 mg
027-17043
5 mg
for Cellbiology
856925-71-8
DMSO (5 mg/mL)
-
Keep at -20℃.
<Calcium ATPase Inhibitors>
Specific inhibitor of myosin II. It inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly in the
vertebrate cell divisions. It has been reported to block blebbing and apoptosis and increases the colony forming rate when human ES cells
are dispersed to single cells from a colony.
Calpain Inhibitor 2, 95.0+ % (HPLC)
038-19811
10 mg
for Cellbiology
110115-07-6 Ethanol, methanol
-
Keep at -20℃.
4. Calcium Signaling
related Inhibitors
<Calpain inhibitors>
This product inhibits neutral cysteine proteinases such as calpain 1, calpain 2, cathepsin B and cathepsin L. It is also a weak inhibitor of
proteasomes.
Chlorpromazine Hydrochloride, 99.0+ % (Titration)
033-10581
10 g
for Biochemistry
69-09-0
Water, ethanol
IC50 = 25 μM
Keep below 25℃.
<Calmodulin antagonists>
Chlorpromazine Hydrochloride is a phenothiazine neuroleptic which induces tranquilization, analgesia, lowering of body temperature by
inhibiting the hypothalamic thermoregulatory mechanism, antiemesis by inhibiting CTZ of the medulla oblongata, inhibition of conditioned
avoidance response, and hypnosis, as well as an antidopaminergic. This reagent potently blocks α-adrenergic receptors. Its mode of action
in the biogenic system is inhibition of calmodulin, similar to trifluoperazine.
Cyclopiazonic Acid, 98.0+ % (HPLC)
030-17171
5 mg
for Biochemistry
18172-33-3
Methanol
IC50 of Ca2+: 0.2 μM; ATPase: 0.35 μM
Keep at -20℃.
Mycotoxin (fungal toxin). It is a specific inhibitor of Ca2+-ATPase.
2,5-Di-t-butylhydroquinone, 99.0+ % (Capillary GC)
040-24681
100 mg
for Biochemistry
046-24683
88-58-4
1g
Benzene，ethanol，
acetone，
IC50 = 66.7 ± 2.1 μM
carbon bisulfide
Keep at RT.
This product inhibits the Ca2+ ATPase of the sarcoplasmic reticulum and does not act on the plasma membrane Ca2+ pump.
E-64d, 97.0+ % (HPLC)
054-08021
1 mg
050-08023
5 mg
for Cellbiology
88321-09-9
Methanol
IC50 = 0.5 μM
Keep at -20℃.
Membrane-permeable cysteine protease inhibitor which is an analog of E-64, a cysteine protease inhibitor isolated from Aspergillus
japonicas. Esters are hydrolyzed when permeated through the membrane and E-64d is considered to change to an activated form, E-64c.
This reagent inhibits calpain and cathepsin. It is used in combination with pepstatin A in order to prevent degradation of LC3-II in the
autophagosome inner membrane during autophagy.
Fluphenazine Dimaleate, 98.0+ % (Titration)
061-01751
1g
for Biochemistry
3093-66-1
Dilute hydrochloric
acid
-
Keep at 2-10℃.
Phenothiazine neuroleptic. It is a calmodulin inhibitor, similar to chlorpromazine.
14
Product Name
Grade
CAS No.
Soluble in
for Cellbiology
72093-21-1
Water
IC50
Storage Condition
Summary
Mastoparan
139-16511
1 mg
IC50 = 15 μM
Keep at -20℃.
Amphiphilic peptide isolated as an ingredient of hornet poison. It activated directly pertussis toxin-sensitive G protein (Gi, G0) by a
mechanism resembling G protein-conjugate type receptors. It also acts as a calmodulin antagonist.
MG-132, 80.0+ % (HPLC)
139-16251
1 mg
135-16253
5 mg
for Cellbiology
133407-82-6
Methanol
IC50 = 1.25 μM
Keep at -20℃.
Membrane-permeable peptide aldehyde protease inhibitor which reversibly inhibits the chymotrypsin-like activity of 26S proteasome.
Quinacrine Dihydrochloride Dihydrate, 95.0+ % (HPLC)
171-00502
25 g
for Biochemistry
69-05-6
Water, ethanol
IC50 = 4.4 μM
Keep below 25℃.
Antimalarial; calmodulin inhibitor; phospholipase inhibitor
Suramin Sodium, 98.0+ % (HPLC)
199-10613
100 mg
193-10611
200 mg
for Biochemistry
129-46-4
Water
IC50 = 4.9 ± 1.2 μM
Keep at RT.
This product inhibits Ca2+ ATPase of the sarcoplasmic reticulum. It also blocks growth factors, including EGF from binding to the cell
envelope.
209-17281
1 mg
205-17283
5 mg
for Cellbiology
67526-95-8
Acetonitrile
IC50 = 0.13 ± 0.02 μM
Keep at -20℃.
Thapsigargin is an endoplasmic reticulum Ca2+-ATPase(SERCA) inhibitor which inhibits all SERCA isoforms. The endoplasmic reticulum
uptake of calcium ion is blocked causing releasing of calcium ions from the endoplasmic reticulum to the cytoplasm, by irreversible inhibition
of SERCA activity.
4. Calcium Signaling
related Inhibitors
Thapsigargin
5. Ion Channel-related
Blockers
5. Ion Channel-related Blockers
(1) Calcium Channel Blockers
Product Name
Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
Summary
ω-Agatoxin IVA (P-type Blocker), from Funnel Web Spider, Agelenopsis aperta
339-42561
0.1 mg
Peptide Institute, Inc.
(4256-s)
145017-83-0
-
Channel selective blockers with Cys-Cys binding. Peptidic ion channel blockers.
ω-Agatoxin TK (P-type Blocker)
339-42941
0.1 mg
(4294-s)
145017-83-0
-
Agelenin, from Spider, Agelena opulenta
330-42471
0.1 mg
(4247-s)
-
-
15
Product Name
Grade/Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
88150-42-9
-
-
Keep at RT.
Summary
Amlodipine, 98.0+ % (HPLC)
011-24951
100 mg
017-24953
1g
for Cellbiology
L-type calcium channel blocker with a hypotensive action.
It acts on cardiovascular system, including facilitation of NO production, inhibition of oxidative stress, and inhibition of adhesion of
monocytes to the endothelium. In addition, it acts for a prolonged period compared to other similar calcium channel blockers.
2,3-Butanedione Oxime
045-00652
25 g
047-00651
100 g
Wako Special Grade
57-71-6
Water, ethanol
IC50 = 15.3 mM
Keep at RT.
2,3-Butanedione Oxime has phosphatase activity and inhibits contraction of skeletal muscles and cardiac muscles.
Calcicludine (L-type Blocker), 99.0+ % (HPLC), from Green Mamba, Dendroaspis angusticeps
337-43101
0.1 mg
(4310-s)
178037-96-2
-
-
Keep at -20℃.
-
Keep at -20℃.
Neuronal L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
Calciseptine (L-type Blocker), from Black mamba, Dendroaspis polylepis polylepis
332-42551
0.1 mg
(4255-s)
-
-
L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
Cinnarizine, 98.0+ % (Titration)
030-13592
25 g
for Biochemistry
Acetone, ether,
chloroform,
benzene
298-57-7
IC50 = 0.75 μM
Keep at RT.
Cinnarizine has antihistaminic and vasodilatory activities, improves cerebral blood flow impairment, and exerts Ca2+ channel inhibitory activity.
ω-Conotoxin GVIA (N-type Blocker), from Marine Snail, Conus geographus
Blockers
336-41611
0.5 mg
(4161-v)
106375-28-4
-
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
ω-Conotoxin MVIIA (N-type Blocker), 99.0+ % (HPLC) from Marine snail, Conus magus
338-42891
0.5 mg
(4289-v)
107452-89-1
-
Reversible N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
ω-Conotoxin MVIIC (P/Q-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus magus
332-42833
336-42831
0.5 mg
(4283-v)
0.1 mg
(4283-s)
147794-23-8
-
P/Q-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
ω-Conotoxin SVIB (N-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus striatus
333-42841
0.5 mg
(4284-v)
150433-82-2
-
N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.
Diltiazem Hydrochloride, 98.0+ % (Titration)
047-20311
1g
043-20313
5g
for Biochemistry
33286-22-5
Formic acid, water,
ethanol, chloroform
IC50 = 4.5 μM
Keep at 2-10℃.
Therapeutic substance for circulatory diseases such as hypertension, angina and arrhythmia.
It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. Specific calcium
antagonists include nifedipine, verapamil and diltiazem.
16
Product Name
Grade/Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
-
Keep at -20℃.
Summary
Kurtoxin, 98.0+ % (HPLC), from Scorpion, Parabuthus transvaalicus
338-43751
0.1 mg
(4375-s)
-
-
T-type Ca2+ channel blocker. Peptidic ion channel blockers.
Nicardipine Hydrochloride, 99.0+ % (HPLC)
145-06381
1g
141-06383
5g
for Biochemistry
54527-84-3
Methanol,
chloroform
IC50 = 2.56 μM
Keep at RT.
It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts.
Nitrendipine, 98.0+ % (HPLC)
142-06411
200 mg
for Biochemistry
39562-70-4
Chloroform,
acetonitrile
IC50 = 23 μM
Keep at RT.
It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. It dilates peripheral
vessels and coronary arteries and has hypotensive and anti-angina actions. Its hypotensive action is comparable to nifedipine, and the action
lasts longer than nifedipine.
PLTX-II, 99.0+ % (HPLC), from Spide, Plectreurys tristes
331-43001
0.1 mg
(4300-s)
-
-
-
Keep at -20℃.
-
-
Keep at -20℃.
-
Keep at -20℃.
Presynaptic Ca2+ Channel Blocker
ProTx-1, 97.0+ % (HPLC), from Tarantula, Thrixopelma pruriens
338-44091
0.1 mg
(4409-s)
-
T-Type Ca2+ Channel / Na+ Channel / K+ Channel Blocker (Gating Modifier)
Ryanodine
185-02821
1 mg
for Cellbiology
15662-33-6
Methanol
Signal transduction Ca channel Inhibitor Ryanodine is an alkaloid isolated from Ryania speciosa Vahl. It acts to increase calcium
permeability by binding to the arcoplasmic reticulum calcium channel.
2+
338-43631
0.1 mg
(4363-s)
203460-30-4
-
-
Keep at -20℃.
Class E (R-type) Ca2+ Channel Blocker
Verapamil Hydrochloride, 98.0+ % (Titration)
222-00781
1g
228-00783
10 g
for Biochemistry
152-11-4
Ethanol
IC50 = 0.3 μM
Keep at RT.
Blockers
SNX-482, 99.0+ % (HPLC), from Tarantula, Hysterocrates gigas
Verapamil HCl directly affects the smooth muscle of blood vessels and the heart and is a Ca2+ antagonist. It also promotes effects of
tumoricidal drugs and is used in research concerning the mechanism of calcium antagonists.
(2) Potassium Channel Blockers
Product Name
Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
-
-
Keep at -20℃.
-
Keep at -20℃.
Summary
Apamin, 99.0+ % (HPLC), from Honeybee, Apis mellifera
336-42571
0.5 mg
(4257-v)
24345-16-2
Small conductance Ca2+-activated K+ channel blocker
Charybdotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus var. hebraeus
338-42271
0.1 mg
(4227-s)
95751-30-7
-
Ca2+-activated K+ channel blocker
17
Product Name
Grade/Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
-
Keep at -20℃.
Summary
Dendrotoxin 1, 99.0+ % (HPLC), from black mamba, Dednroaspis polylepis polylepis
339-43301
0.1 mg
(4330-s)
107950-33-4
-
-
Water
Voltage-dependent K+ channel blocker
E-4031 n-Hydrate, 98.0+ % (HPLC)
059-08451
10 mg
055-08453
50 mg
for Cellbiology
Native guinea pig HERG channel: IC50 =
397 nM
Keep at -20℃.
E-4031 is a HERG potassium channel blocker with antiarrhythmic action (class III ). It selectively inhibits Ikr, a rapid component of the delayed
rectifier K current, during repolarization after muscle cells are depolarized.
Glibenclamide, 98.0+ % (Titration)
078-03881
5g
076-03882
25 g
for Biochemistry
10238-21-8
DMF
IC50 = 0.1 μM
Keep at RT.
<Potassium Channel Blockers>
Sulfonylurea hypoglycemic substance. It blocks ATP-dependent K+ channel of the pancreas to increase intracellular Ca2+, thus increasing
insulin secretion. It pharmacologically antagonizes the action of K+ channel-opening agents in the heart and blood vessels.
Guangxitoxin-1E, 97.0+ % (HPLC), from Tarantula, Plesiophrictus guangxiensis sp. nov.
334-44331
0.1 mg
(4433-s)
-
-
Keep at -20℃.
-
Keep at -20℃.
-
-
Keep at -20℃.
-
-
Keep at -20℃.
-
-
Keep at -20℃.
-
Keep at -20℃.
-
Kv2.1/Kv2.2 channel blocker / Enhancer of glucose-dependent insulin secretion
Iberiotoxin, 99.0+ % (HPLC), from Scorpion, Buthus tamulus
330-42351
0.1 mg
(4235-s)
129203-60-7
-
Highly selective and potent high conductance Ca2+-activated K+ channel blocker
Kaliotoxin (1-37), 99.0+ % (HPLC), from Scorpion, Androctonus mauretanicus mauretanicus
Blockers
330-42591
0.1 mg
(4259-s)
145199-73-1
High conductance Ca2+-activated K+ channel blocker
Margatoxin【MgTX】, 99.0+ % (HPLC)
331-42901
0.1 mg
(4290-s)
145808-47-5
Voltage-dependent K+ channel blocker (specific for Kv1.3 channel )
MCD-Peptide, 99.0+ % (HPLC), from Honeybee, Apis mellifera
333-42581
0.5 mg
(4258-v)
32908-73-9
Voltage-dependent K+ channel blocker
Scyllatoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus hebraeus
333-42601
0.1 mg
(4260-s)
116235-63-3
-
Small conductance Ca2+-activated K+ channel blocker
Stichodactyla Toxin, 99.0+ % (HPLC), from Sea Anemone, Stichodactyla helianthus
334-42871
0.1 mg
(4287-s)
-
-
-
Keep at -20℃.
58694-52-3
-
-
Keep at -20℃.
Voltage-dependent K+ channel (A channel) blocker
Tertiapin, 99.0+ % (HPLC), from Apis mellifera
335-43641
0.1 mg
(4364-s)
Potent blocker of inward-rectifier K+ channels such as ROMK1 and GIRK1/4 at 2.5-10 nM.
18
Product Name
CAS No.
Manufacturer
Soluble in
IC50
Storage Condition
-
-
Keep at -20℃.
Soluble in
IC50
Storage Condition
Summary
Tityustoxin Kα, 99.0+ % (HPLC), from Scorpion, Tityus serrulatus
338-43131
0.1 mg
(4313-s)
39465-37-7
Voltage-dependent K+ channel (A channel) blocker
(3) Sodium Channel Blockers
Product Name
CAS No.
Grade/Manufacturer
Summary
Clotrimazole, 98.0+ % (HPLC)
035-16021
5g
033-16022
25 g
for Biochemistry
23593-75-1
Ethanol, chloroform,
IC50 = 1.8 μM
carbon tetrachloride
Keep at RT.
It exhibits bactericidal action by destroying cytoplasmic membranes of fungi.
μ-Conotoxin G3B, 99.0+ % (HPLC), from Marine Snail, Conus geographus
332-42171
0.5 mg
(4217-v)
140678-12-2
-
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
Na+ channel blocker: Specific for skeletal muscle
μ-Conotoxin GS, 95.0+ % (HPLC), from Marine Snail, Conus geographus
334-42631
0.5 mg
(4263-v)
171358-00-2
-
Selective blocker of Na+ channels of skeletal muscles.
μ-Conotoxin SIIIA, 99.0+ % (HPLC), from Marine Snail, Conus striatus
339-44401
0.5 mg
(4440-v)
877860-32-7
-
Tetrodotoxin-resistant Na+ channel blocker with analgesic activity
Huwentoxin-IV, 97.0+ % (HPLC), from Chinese Bird Spider, Ornithoctonus huwena
0.1 mg
(4455-s)
-
-
73590-58-6
Dichloromethane,
methanol
Neuronal tetrodotoxin-sensitive Na+-channel blocker
Omeprazole, 98.0+ % (HPLC)
150-02091
10 g
158-02092
25 g
for Biochemistry
IC50 = 4.2 μM
Keep at -20℃.
Blockers
330-44551
Eradicating agent for Helicobacter pylori (HP).
Selective inhibitor of gastric H+, K+ ATPase (proton pump), and used as a marker to test the susceptibility of HP to this product in vitro.
ProTx-II, 99.0+ % (HPLC)
335-44501
0.1 mg
4450-s
-
-
Keep at -20℃.
CAS No.
Soluble in
IC50
Storage Condition
545395-94-6
Ethanol
-
Keep at 2-10℃.
-
Na+ channel (especially Nav1.7) / Ca2+ channel blocker (gating modifier)
(4) Transient Receptor Potential (TRP) Channel Blockers
Product Name
Grade
Summary
AMG 9810, 98.0+ % (HPLC)
015-25071
10 mg
011-25073
50 mg
for Cellbiology
Antagonist of transient receptor potential vanilloid 1 (TRPV1). TRPV1 is one of the TRP channels cloned as a capsaicin receptor, functions
as a pain receptor, and is activated by capsaicin, heat, and protons. It also inhibits the activation of TRPV1 by heat and protons, besides
capsaicin.
19
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
for Cellbiology
55224-94-7
Ethanol
(10 mg/2 mL)
-
Keep at -20℃.
Summary
AP 18, 98.0+ % (HPLC)
014-25161
10 mg
010-25163
50 mg
Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor. TRPA1 is involved in pain transmission, and its involvement in respiratory
depression has also been reported.
2-APB, 98.0+ % (HPLC)
013-24911
100 mg
019-24913
500 mg
for Cellbiology
524-95-8
Ethanol
-
Keep at -20℃.
Inhibitor of inositol triphosphate (IP3) receptors. It can also block TRP channels TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7,
TRPM8 and TRPP2. At high concentrations, it can activate TRPV1, TRPV2 and TRPV3.
BCTC, 98.0+ % (HPLC)
027-18241
10 mg
023-18243
50 mg
for Cellbiology
393514-24-4
Ethanol
-
Keep at -20℃.
TRPV1 antagonist. It inhibits the activation of TRPV1 by capsaicin and acids.
Capsazepine, 98.0+ % (HPLC)
037-23171
10 mg
033-23173
50 mg
for Cellbiology
138977-28-3
Ethanol
-
Keep at 2-10℃.
349085-38-7
DMSO
-
Keep at RT.
Ethanol
-
Keep at -20℃.
TRPV1 antagonist. Capsaicin analog.
HC-030031, 98.0+ % (HPLC)
086-09961
10 mg
082-09963
50 mg
for Cellbiology
Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor.
Blockers
Olvanil, 98.0+ % (HPLC)
154-03231
10 mg
150-03233
50 mg
for Cellbiology
58493-49-5
It demonstrated to block intracellular accumulation of Anandamide through interaction with the anandamide transporter at concentrations
similar to those needed for TRPV1 activation. Also inhibits FAAH (fatty acid amide hydrolase). It also acts as a potent TRPV1 angonist and a
CB1 agonist.
RN-1747, 98.0+ % (HPLC)
183-02981
10 mg
189-02983
50 mg
for Cellbiology
1024448-59-6
DMSO
-
Keep at 2-10℃.
TRPM8 antagonist. It also acts as a TRPV4 (transient receptor potential vanilloid 4)-selective agonist.
Ruthenium Red
184-00331
100 mg
180-00333
1g
Wako Special Grade
11103-72-3
Water
-
Keep at RT.
472981-92-3
Ethanol
-
Keep at -20℃.
TRPA1 antagonist.
SB-366791, 98.0+ % (HPLC)
193-17431
10 mg
199-17433
50 mg
for Cellbiology
TRPV1 antagonist, which inhibits the activation of TRPV1 by capsaicin and heat. It has been reported that it does not inhibit activation by
protons.
20
(5) Acid-Sensing Ion Channel Blockers
Product Name
Manufacturer
CAS No.
Soluble in
IC50
Storage Condition
713544-47-9
-
-
Keep at -20℃.
Summary
APETx2, 99.0+ % (HPLC)
331-44721
0.1 mg
(4472-s)
Selective blocker of acid-sensing ion channel blocker, ASIC3
Psalmotoxin 1, 97.0+ % (HPLC), from South American Tarantula, Psalmopoeus cambridgei (Trifluoroacetate Form)
338-44351
0.1 mg
(4435-s)
-
-
-
Keep at -20℃.
Soluble in
IC50
Storage Condition
Selective blocker of ASIC1a
(6) Nicotinic Acetylcholine Receptor Blockers
Product Name
Manufacturer
CAS No.
Summary
α-Conotoxin G1, 97.0+ % (HPLC), from Marine Snail, Conus geographus (Hydrochloride Form)
337-41261
0.5 mg
(4126-v)
76862-65-2
-
-
Keep at -20℃.
-
Keep at -20℃.
-
Keep at -20℃.
Nicotinic acetylcholine receptor blocker
α-Conotoxin ImI, 99.0+ % (HPLC), from Marine Snail, Conus imperialis
334-43111
0.5 mg
(4311-v)
156467-85-5
-
Nicotinic acetylcholine receptor blocker in central nervous system
α-Conotoxin M1, 99.0+ % (HPLC), from Marine Snail, Conus magus
337-41401
0.5 mg
(4140-v)
88217-10-1
-
335-42281
0.5 mg
(4228-v)
133605-58-0
-
-
Keep at -20℃.
CAS No.
Soluble in
IC50
Storage Condition
(7) Other Blockers
Product Name
Manufacturer
Blockers
α-Conotoxin SI, 99.0+ % (HPLC), from Marine Snail, Conus striatus
Summary
Chlorotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus
339-42821
0.5 mg
(4282-v)
163515-35-3
-
-
Keep at -20℃.
-
-
-
Keep at -20℃.
-
Keep at -20℃.
Small-conductance Cl- channel blocker
GsMTx-4, 99.0+ % (HPLC)
336-43931
0.1 mg
(4393-s)
Inhibitor for cation-selective stretch-activated channels / Atrial fibrillation inhibiting peptide
Purotoxin-1, 99.0+ % (HPLC)
334-44571
0.1 mg
(4457-s)
-
-
P2X3 purinoreceptor inhibitor
21
6.G-protein Signaling and Second Messenger-related Inhibitors
Product Name
CAS No.
Grade/Manufacturer
Soluble in
IC50
Storage Condition
Summary
Andrographolide, 98.0+ % (HPLC)
014-15271
500 mg
for Biochemistry
5508-58-7
Methanol, acetone IC50 = 5.6 ± 0.7 μM
Keep at 2-10℃.
<Guanylate Cyclase Inhibitors>
It is reported to suppress the decrease of glutathion and to counteract toxic liver damage caused by substances such as carbontetrachloride
and t-butylhydroperoxide.
BAY 11-7085, 98+ % (NMR)
020-14331
10 mg
026-14333
25 mg
for Biochemistry
196309-76-9
Ethanol, acetone
IC50 = 10 μM
Keep at -20℃.
<NFκB Inhibitors>
Inhibitor of cytokine-induced IκBα phosphorylation and decreases expression of NFκB and adhesion molecule. It also exhibits strong
antiinflammatory activity.
8-(4-Chlorophenylthio)adenosine 3',5'-(Cyclic)monophosphate Sodium Salt, 98.0+ % (HPLC)
039-18121
10 mg
035-18123
100 mg
for Biochemistry
93882-12-3
Water
IC50 of PKA: 900 nM; PKG: 25 μM
Keep at -20℃.
<Adenylate Cyclase Inhibitors>
Cell permeable cAMP analog, used as an activator of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG).
Curcumin
038-04921
1g
036-04922
25 g
Wako Special Grade
IC50 of 5-Lipoxygenase: 5 - 10 μM,
COX ≦ 100 μM
458-37-7
Ethanol, acetic acid
477-57-6
-
-
Keep at 2-10℃.
Ethanol, acetone
IC50 of soluble Guanylate cyclase in human
platelets: 2 μM; leukotriene synthesis in
guinea pig lung and rat celiac cells: 1.8 μM
Keep at -20℃.
Keep at RT.
Inhibitor of 5-lipoxygenase and cyclooxygenase.
Isotetrandrine
306-01771
25 mg
Kaken Shoyaku Co.,
Ltd.
<G-protein Signaling Inhibitor>
A biscoclaurine alkaloid inhibitor of G protein activation of PLA2
LY-83583, 94+ % (TLC)
128-04691
5 mg
for Biochemistry
91300-60-6
It decreases the concentration of cellular cGMP through the inhibition of guanylate cyclase.
NS2028, 98.0+ % (HPLC)
6. G-protein Signaling and Second
Messenger-related Inhibitors
149-06921
5 mg
for Biochemistry
204326-43-2
Water, ethanol
-
Keep at -20℃.
Selective inhibitor of soluble guanylate cyclase (sGC) that is sensitive to NO. It does not inhibit sGC activity enhanced by YC-1 or CO.
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one【ODQ】, 97.0+ % (HPLC)
153-01981
10 mg
159-01983
25 mg
for Biochemistry
41443-28-1
Ethanol, acetone
-
Keep at 2-10℃.
It inhibits the guanylate cyclase activity of NO produced by NOS rather than NO synthase (NOS), and controls the increase in cGMP.
Pentoxifylline, 98.0+ % (Titration)
160-18761
10 g
for Biochemistry
6493-05-6
Methanol, ethanol,
TNFα: IC50 = 100 μM
acetone, water
Keep at RT.
TNF-α synthesis inhibior and phosphodiesterase inhibitor
22
Product Name
Grade
CAS No.
Soluble in
for Biochemistry
61413-54-5
Ethanol
IC50
Storage Condition
Summary
Rolipram, 98+ % (TLC)
180-01411
10 mg
IC50 = 20 μM
Keep at 2-10℃.
<NFκB Inhibitors>
This cAMP diphosphodiesterase inhibitor selectively inhibits phosphodiesterase IV, a type of isozyme. Improvement of arthritis (in rats with
collagen II induced arthritis) has been reported.
7.Neurotransmitter Inhibitors
(1) Glutamate Receptor Antagonists
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Hydrochloric acid,
water
-
Keep at 2-10℃.
Summary
DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)
013-22071
100 mg
for Cellbiology
6323-99-5
NMDA-type glutamate receptor antagonists.
L-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)
016-22083
10 mg
for Cellbiology
23052-81-5
Water
EC50 = 16.0 μM
Keep at 2-10℃.
Selective agonist for group III metabotropic glutamate receptors ( mgluR4, mgluR6).
D(-)-2-Amino-5-phosphonovaleric Acid 【D-AP5】
015-18481
10 mg
for Biochemistry
79055-68-8
Hydrochloric acid
IC50 = 3.7 ± 0.32 μM
Keep at RT.
A neural amino acid. It is a potent antagonist of the NMDA-type receptor, which is one of the ion-channel glutamine receptors.
DL-2-Amino-5-phosphonovaleric Acid 【DL-AP5】
018-18471
10 mg
for Biochemistry
76326-31-3
Water
IC50 = 90 μM
Keep at RT.
(R)-CPP
031-22091
1 mg
037-22093
5 mg
for Cellbiology
126453-07-4
Water (10 mg/mL)
-
Keep at RT.
Highly potent glutaminergic NMDA receptor antagonist. It exhibits a higher activity than racemic CPP. It is selective to NR2A in NMDA
receptor.
Dextromethorphan Hydrobromide Monohydrate, 98.0+ % (Titration)
041-21551
5g
049-21552
25 g
for Biochemistry
Methanol, acetic
acid, ethanol
-
Keep below 25℃.
364-98-7
DMSO
-
Keep at RT.
85797-13-3
NaOH soln.
IC50 = 11.1 ± 2.1 μM
Keep at RT.
NMDA receptor antagonist.
Diazoxide, 99.0+ % (HPLC)
047-23133
250 mg
041-23131
1g
for Biochemistry
Desensitization blocker of AMPA receptor.
DL-AP7, 98.0+ % (1H- NMR)
041-31941
5 mg
for Cellbiology
DNQX, 95+ % (TLC)
044-26301
50 mg
for Biochemistry
AMPA/Kainate receptor antagonist
2379-57-9
Methanol
-
Keep at -20℃.
7. Neurotransmitter
Inhibitors
6. G-protein Signaling and Second
Messenger-related Inhibitors
6700-34-1
23
Product Name
Grade
CAS No.
Soluble in
Practical Grade
314-13-6
Water
25451-15-4
DMSO, ethanol
IC50
Storage Condition
Summary
Evans Blue
056-04061
5g
054-04062
25 g
IC50 = 87 nM
Keep at RT.
AMPA/Kainate receptor antagonist.
Felbamate, 98.0+ % (HPLC)
060-05861
10 mg
066-05863
50 mg
for Cellbiology
IC50 = 0.78 ± 0.07 mM
Keep at -20℃.
Allosteric antagonist of NR2B subunit of glutaminergic NMDA receptor and exhibits strong anticonvulsant action. It also has a property as a
γ-aminobutyric acid (GABA) receptor agonist.
Joro Spider Toxin JSTX-3, 98.0+ % (HPLC)
104-00051
0.1 mg
for Biochemistry
112163-33-4
Water
IC50 = 1.7 μM
Keep at 2-10℃.
Toxin isolated from Joro Spider poison gland, paralyzes the movement of arthropods (insects, crustaceans, etc.). It irreversibly blocks
excitatory transmissions of neurons and muscles by glutamate released from the synaptic terminal of motor neurons. It acts selectively on
quisqualate glutamate receptor.
Loperamide Hydrochloride
129-05721
5g
127-05722
25 g
for Pharmacology
Research
34552-83-5
Methanol, ethanol
IC50 = 0.9 ± 0.2 μM
Keep at RT.
NMDA receptor antagonist. It reduces Ca2+ flow. Loperamide Hydrochloride is a NMDA receptor antagonist that reduces the flow of Ca2+.
It is an antidiarrheal agent that inhibits both peristaltic movement of the intestinal tract and secretion, and enhances absorption, via opioid
receptor in the intestinal tract.
(+)-MCPG, 99.0+ % (HPLC)
135-16111
2 mg
131-16113
10 mg
for Cellbiology
150145-89-4
0.1M NaOH
IC50 = 272 μM
Keep at 2-10℃.
Competitive antagonist for group 1 (mGluR1, mGluR5) and group 2 (mGluR2, mGluR3) metabotropic glutamate receptors. It is an active
enantiomer of (±)-MCPG.
Memantine Hydrochloride
132-16981
25 mg
138-16983
100 mg
for Cellbiology
41100-52-1
Water
IC50 = 1.2 ± 0.2 μM
Keep at RT.
This is a glutaminergic NMDA receptor antagonist and stimulates dopamine release by binding to the ion channel site. It is used in
researches on Parkinson's disease, spasms, Alzheimer's disease and so on.
(+)-MK 801 Maleate, 98.0+ % (HPLC)
130-17381
10 mg
136-17383
50 mg
for Cellbiology
77086-22-7
Methanol
Ki = 30.5 ± 1.5 nM
Keep at 2-10℃.
Selective antagonist of NMDA glutamate receptor. It inhibits calcium ion influx across cell membranes by binding mainly to the pore of the
ion channel opened upon the ligand binding. It is known as an anti-ischemic agent.
NBQX Disodium Salt, 98.0+ % (HPLC)
147-08661
10 mg
for Cellbiology
479347-86-9
Water
-
Keep at 2-10℃.
Water-soluble NBQX. NBQX is a potent and competitive AMPA/kainate receptor antagonist.
NBQX, 99+ % (TLC)
7. Neurotransmitter
Inhibitors
148-06751
24
10 mg
for Biochemistry
118876-58-7
Acetone
IC50 = 0.90 μM
Keep at 2-10℃.
IC50 = 2 - 18 μM
Keep at -20℃.
Antagonist of the AMPA/kainate receptor.
Pentamidine Isethionate, 98.0+ % (HPLC)
166-25191
50 mg
for Cellbiology
140-64-7
Water
This substance exhibits nerve protection activity and inhibits homeostatic NO synthase in the brain. It is an antagonist to NMDA glutamate
receptor. It inhibits glucose metabolism and protein synthesis in Pneumocystis carinii.
Product Name
Grade
CAS No.
Soluble in
71-44-3
Water, chloroform
IC50
Storage Condition
Summary
Spermine, 95.0+ % (Titration)
198-09811
250 mg
194-09813
1g
for Biochemistry
IC50 = 170 μM
Keep at 2-10℃.
Agonist during depolarization and antagonist during hyperpolarization.
(2) Inhibitors of Angiotensin Conversion Enzyme
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Ethanol
-
Keep at RT.
Summary
Benazepril Hydrochloride, 97.0+ % (HPLC)
024-14091
1g
020-14093
5g
for Biochemistry
86541-74-4
ACE inhibitor used clinically as a therapeutic for hypertension.
Captopril, 96.0+ % (Titration)
039-20951
1g
035-20953
5g
037-20952
25 g
for Pharmacology
Research
62571-86-2
Methanol, acetone,
water
Keep below 25℃.
IC50 = 9 nM
Angiotensin converting enzyme (ACE) inhibitor that blocks ACE and inhibits the pressor system while enhancing the depressor system. It is a
crude drug for essential and renal hypertensions.
Enalaprilat Dihydrate, 98.0+ % (HPLC)
055-06851
1g
for Biochemistry
84680-54-6
Methanol
IC50 = 4.8 nM
Keep at RT.
This is an active form of enalapril, which is an angiotensin converting enzyme (ACE) inhibitor. One of the percutaneous vasodilators.
Enalapril Maleate, 98.0+ % (HPLC)
051-06711
1g
057-06713
5g
for Biochemistry
76095-16-4
Methanol, ethanol
IC50 = 1 - 10 nM
Keep at RT.
IC50 = 1.2 nM
Keep at RT.
It inhibits angiotensin II synthesis by inhibiting angiotensin converting enzyme.
Lisinopril Dihydrate, 98.0+ % (HPLC)
128-04711
1g
124-04713
5g
for Biochemistry
76547-98-3
Water
It inhibits angiotensin II production by blocking angiotensin converting enzyme, and has antihypertensive effects. It is a crude drug for
treating hypertension, chronic heart failure, etc.
(3) Cannabinoid Receptor Antagonists
Product Name
Grade
CAS No.
for Biochemistry
149301-79-1
Soluble in
IC50
Storage Condition
Summary
011-18461
10 mg
Ethanol
IC50 = 15 μM
Selective inhibitor of cellular phospholipase A2 (cPLA2) and Ca independent phospholipase A2 (iPLA2) (IC50 = 15 μM).
2+
Keep at -20℃.
7. Neurotransmitter
Inhibitors
AACOCF3
25
Product Name
Grade
CAS No.
Soluble in
for Cellbiology
183232-66-8
DMSO, DMF
IC50
Storage Condition
Summary
AM 251, 95.0+ % (HPLC)
011-24191
2 mg
017-24193
10 mg
015-24194
50 mg
IC50 = 8.9 μM
Keep at -20℃.
Potent CB1 receptor antagonist/inverse agonist. Ki = 7.5 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.
AM 281, 97.0+ % (HPLC)
012-22161
2 mg
018-22163
10 mg
for Cellbiology
202463-68-1
Methanol
Keep at 2-10℃.
IC50 = 6 nM
Potent CB1 receptor antagonist/inverse agonist. Ki = 14 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.
AM 630
019-22551
2 mg
015-22553
10 mg
for Cellbiology
164178-33-0
DMSO
IC50 = 6.3 μM
Keep at 2-10℃.
Antagonist/inverse agonist of cannabinoid receptor subtype CB2 (Ki = 31.2 nM).
(4) GABA Receptor Antagonists
Product Name
Grade
CAS No.
Soluble in
485-49-4
Methanol,
chloroform
IC50
Storage Condition
Summary
(+)-Bicuculline, 98.0+ % (HPLC)
026-16131
50 mg
022-16133
250 mg
for Cellbiology
IC50 = 4.5 μM
Keep at -20℃.
Lactone of bixin, known for its use as a proconvulsant. It is a selective antagonist of GABA(A) receptor, a GABA receptor subtype that exists
in the central and peripheral nervous systems. Because this reagent binds to GABA binding site, it competitively blocks GABA and muscimol
actions.
(-)-Bicuculline Methobromide
026-14291
100 mg
for Biochemistry
IC50 = 15 nM
Keep at 2-10℃.
-
IC50 = 0.8 ± 0.2 μM
Keep at -20℃.
124-87-8
Ethanol
IC50 = 2.6 ± 0.4 μM
Keep at RT.
17617-45-7
Ethanol, Chloroform
IC50 = 25 ± 0.4 μM
Keep at 2-10℃.
73604-30-5
Water
GABAA receptor antagonist.
(-)-Bicuculline Methochloride, 93.0+ % (HPLC)
026-17611
10 mg
022-17613
50 mg
for Biochemistry
53552-05-9
Water-soluble methochloride salt of (+)-bicuculline
Picrotoxin, 97.0+ % (HPLC)
168-17961
1g
164-17963
5g
Wako 1st Grade
GABAA receptor antagonist.
Picrotoxinin, 95.0+ % (HPLC)
165-17351
500 mg
for Biochemistry
7. Neurotransmitter
Inhibitors
A bitter component isolated from a plant of family Menispermaceae (Anamirta cocculus). The toxic moiety of picrotoxin (central nerve
excitation agent), which blocks the Cl- channel in an allosterical manner that forms a molecular complex with GABA receptors.
26
(5) Serotonin-related Inhibitors
Product Name
CAS No.
Grade
Soluble in
IC50
Storage Condition
Summary
Amitriptyline Hydrochloride, 99.0+ % (Titration)
013-12882
25 g
for Biochemistry
549-18-8
Water, chloroform, 5-HT: IC50 = 39 nM
ethanol
NA: IC50 = 21 nM
Keep at RT.
Tricyclic antidepressant substance, anxiolytic substance. It inhibits reuptake of noradrenaline and serotonin in the brain and exerts an
antidepressant action.
Amoxapine, 98.0+ % (HPLC)
015-23631
011-23633
1g
5g
for Pharmacology
Research
14028-44-5
Acetic acid,
glacial, chloroform,
dichloroethane
-
Keep at RT.
This is a tricyclic antidepressant. It inhibits reuptake of serotonin (5-HT) and noradrenaline in nerve terminals in the brain.
Azasetron Hydrochloride, 90.0+ % (HPLC)
014-24441
50 mg
010-24443
200 mg
for Biochemistry
123040-16-4
Water
-
5-HT3 Receptor Antagonist
Blonanserin, 98.0+ % (HPLC)
022-17451
5 mg
028-17453
50 mg
for Pharmacology
Research
132810-10-7
Acetonitrile, acetic
Ki = 0.812 nM (5-HT2A); 0.142 nM
acid, methanol,
(Dopamine D2); 0.494 nM (Dopamine D3)
ethanol
Keep at RT.
This substance binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.
DL-p-Chlorophenylalanine, 99.0+ % (Titration)
037-10741
1g
033-10743
5g
035-10742
25 g
Wako Special Grade
7424-00-2
Dilute hydrochloric
acid
-
Keep at RT.
It irreversibly binds to tryptophan hydroxylase and decreases intracerebral serotonin (serotonin synthetic inhibitor).
Citalopram Hydrobromide, 98.0+ % (HPLC)
031-22231
25 mg
037-22233
100 mg
for Pharmacology
Research
59729-32-7
Water, ethanol
IC50 = 1.8 nM
Keep at 2-10℃.
Citalopram Hydrobromide is a selective serotonin reuptake inhibitor (SSRI). This reagent blocks the reuptake of intracerebral serotonin
and exhibits antidepressive effects by increasing serotonin in the synaptic cleft. It is considered to have almost no affinity for other
neurotransmitter receptors.
Clomipramine Hydrochloride, 98.0+ % (volumetric analysis), 98.0+ % (HPLC)
036-21941
032-21943
1g
5g
for Pharmacology
Research
17321-77-6
Water, acetic
acid, methanol,
chloroform
IC50 of 5-HT: 1.5 nM; NA: 24 nM
Keep at RT.
Clomipramine Hydrochloride is a derivative of imipramine and has tricyclic antidepressant effects. This reagent blocks the uptake of
intracerebral serotonin (5-HT) and noradrenaline into the nerve terminal. It potently blocks serotonin uptake.
Desipramine Hydrochloride, 99.0+ % (Titration); 99+ % (TLC)
044-23121
1g
040-23123
5g
for Biochemistry
58-28-6
Chloroform, water,
IC50 of 5-HT: 382 nM; NA: 1.26 nM
ethanol
Keep at RT.
Tricyclic antidepressant. It binds to amine transporter and blocks reuptake of intracerebral serotonin (5-HT) and noradrenaline into the nerve
terminal. It is an active metabolite of imipramine.
043-32001
1g
049-32003
5g
for Pharmacology
Research
1229-29-4
Water
IC50 of 5-HT: 280 nM; NA: 40 nM
Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.
Keep at RT.
7. Neurotransmitter
Inhibitors
Doxepin Hydrochloride (mixture of isomers), 98.0+ % (HPLC)
27
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
Summary
Duloxetine Hydrochloride, 98.0+ % (HPLC)
041-32041
10 mg
047-32043
100 mg
for Pharmacology
Research
136434-34-9
Methanol, DMSO
IC50 of 5-HT: 6.3 nM; NA: 5.8 nM
Keep at RT.
Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.
(±)-Fluoxetine Hydrochloride, 98.0+ % (HPLC)
068-04321
10 mg
064-04323
50 mg
068-04326
1g
for Biochemistry
56296-78-7
Methanol, ethanol,
acetonitrile,
IC50 = 6.8 nM
chloroform,
acetone
Keep below 25℃.
Selective serotonin reuptake inhibitor (SSRI). It inhibits serotonin reuptake and consequently elevates serotonin concentration in synaptic
gaps exhibiting antidepressive effect.
Fluvoxamine Maleate
065-05171
5g
061-05173
100 g
for Pharmacology
Research
61718-82-9
Ethanol
IC50 = 0.29 nM
Keep at 2-10℃.
Selective serotonin reuptake inhibitor (SSRI). It is used for treating melancholia, depression, obsessive compulsive disorder, and social
anxiety disorder.
Granisetron Hydrochloride, 98.0+ % (HPLC)
073-06131
5 mg
079-06133
50 mg
for Pharmacology
Research
107007-99-8
Water
IC50 = 0.20 nM
Keep at 2-10℃.
IC50 of 5-HT: 28.0 nM; NA: 29.6 nM
Keep at -20℃.
Highly selective serotonin receptor 5-HT3 antagonist. It is an antiemetic.
Milnacipran Hydrochloride, 98.0+ % (HPLC)
133-17011
25 mg
139-17013
100 mg
for Pharmacology
Research
101152-94-7
Water
Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals
thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.
Olanzapine, 98.0+ % (HPLC)
150-03071
156-03073
50 mg
500 mg
for Pharmacology
Research
132539-06-1
Acetonitrile
Ki of 5-HT2A: 2.5 nM; 5-HT2B: 11.8 nM;
5-HT2C: 28.6 nM; 5-HT6: 2.5 nM;
Dopamine D2: 11 nM; Dopamine D3: 16 nM;
Dopamine D4: 27 nM; α1-adrenaline: 19 nM;
Histamine H1: 7 nM
Keep at RT.
Olanzapine antagonizes various neuronal receptors including serotonin 5-HT2A, 2B, 2C, 5-HT6, dopamine D2, D3, D4, α1-adrenaline,
histamine H1 receptors.
Paroxetine Hydrochloride, 98.0+ % (HPLC)
168-24431
100 mg
for Pharmacology
Research
78246-49-8
Water
IC50 = 0.29 nM
Keep below 25℃.
Potent and selective serotonin reuptake inhibitor (SSRI) in the serotonin neuron system in brain
Perospirone Hydrochloride Dihydrate, 98.0+ % (HPLC)
167-25241
5 mg
163-25243
50 mg
for Pharmacology
Research
192052-81-6
Methanol, ethanol,
5-HT2: Ki=0.61 nM; Dopamine D2: 1.4 nM
acetonitrile, water
Keep at RT.
It binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.
7. Neurotransmitter
Inhibitors
Quetiapine Fumarate, 98.0+ % (HPLC)
28
172-00691
178-00693
1g
10 g
for Pharmacology
Research
111974-72-2
N,NDimethylformamide
IC50 of 5-HT2: 148 nM; Dopamine D2:
329 nM; adrenaline α1: 94 nM;
Histamine H1: 30 nM
Keep at RT.
Dibenzothiazepine compound. It inhibits dopamine D2 receptor and serotonin 5HT2 receptor. It shows affinity to a number of receptors other
than dopamine D2 and serotonin 5HT2. It shows higher affinity to serotonin 5HT2 receptor than dopamine D2 receptor.
Product Name
Grade
CAS No.
Soluble in
IC50
Storage Condition
for Pharmacology
Research
106266-06-2
Methanol
-
Keep at RT.
Summary
Risperidone
188-02311
50 mg
184-02313
250 mg
It binds selectively to dopamine D2 receptor and serotonin 5-HT2A receptor and exhibits antagonistic activities.
Sertraline Hydrochloride, 98+ % (HPLC)
193-16191
100 mg
199-16193
1g
for Pharmacology
Research
79559-97-0
Methanol
IC50 = 0.058 μM
Keep at RT.
Selective serotonin reuptake inhibitor (SSRI). It exhibits antidepressant activity by the inhibition of serotonin reuptake in the brain and
increase in the amount of serotonin in synaptic gaps.
Trazodone Hydrochrolide, 98.0+ % (HPLC)
209-14964
500 mg
for Biochemistry
25332-39-2
Water
IC50 of 5-HT uptake: 580 nM;
NA uptake: 11 μM
Keep at 2-10℃.
Triazolopyridine antidepressant, which acts more selectively on serotonin than on noradrenaline in its inhibition of monoamine reuptake and
exerts antidepressant activity. It has almost no anti-cholinergic effects and hardly inhibits reuptake of noradrenalin in the heart.
Venlafaxine Hydrochloride, 98.0+ % (HPLC)
227-01951
500 mg
for Pharmacology
Research
99300-78-4
Water
Ki = 41.0 ± 9.1 μM
Keep at RT.
Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals
thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.
(6) Dopamine Receptor Antagonists
Product Name
CAS No.
Soluble in
129722-12-9
Benzyl alcohol,
acetic acid
Grade
IC50
Storage Condition
Summary
Aripiprazole, 98.0+ % (HPLC)
017-23831
100 mg
013-23833
1g
for Pharmacology
Research
IC50 = 37 nM (with 100 nM Dopamine)
Keep at RT.
Quinoline derivative antagonist of dopamine D2 receptor when dopamine is insufficient. It also acts as partial agonist of serotonin 5-HT1A
receptor and dopamine D2 receptor and antagonist of serotonin 5-HT2A receptor.
Bupropion Hydrochloride, 98.0+ % (HPLC)
028-17311
100 mg
024-17313
1g
for Pharmacology
Research
21535-47-7
Methanol
IC50 of NA transporter: 1.4 μM;
DA transporter: 2.8 μM
Keep at RT.
Noradrenaline-dopamine reuptake inhibitors (DNRIs).
It inhibits the reuptake of noradrenalin and dopamine into the nerve terminals in the brain, thereby increasing the extracellular serotonin
concentrations of noradrenaline and dopamin in the brain.
Clozapine, 98.0+ % (HPLC)
038-22741
10 mg
034-22743
50 mg
for Pharmacology
Research
5786-21-0
Ethanol
IC50 of D4: 9 nM; 5-HT2A: 12 nM;
5-HT2C: 8 nM
Keep at RT.
Subtype D4 selective dopamine receptor antagonist. It also antagonizes serotonin receptors (5-HT2A, 5-HT2C, 5-HT3, 5-HT6, 5-HT7).
Haloperidol, 98.0+ % (Titration)
1g
080-04263
5g
082-04262
25 g
Wako Special Grade
52-86-8
Acetic acid, glacial,
chloroform
-
Keep at RT.
Haloperidol antagonizes especially dopamines at the dopamine receptor and blocks their action.
(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)
191-15531
10 mg
197-15533
50 mg
for Cellbiology
125941-87-9
DMF
IC50 of D1: 0.2 nM; D5: 0.3 nM
Keep at 2-10℃.
7. Neurotransmitter
Inhibitors
084-04261
Potent dopamine D1 receptor antagonist. It also potently agonizes 5-HT1C/2C receptors.
29
Product Name
CAS No.
Soluble in
15676-16-1
Acetic acid, glacial
Grade
IC50
Storage Condition
Summary
(±)-Sulpiride, 98.0+ % (Titration)
190-12061
1g
198-12062
25 g
196-12063
100 g
for Biochemistry
Keep at 2-10℃.
D2: IC50 = 4 nM
This product blocks dopamin D2 receptors, thereby increasing the extracellular dopamine levels in the brain. It exhibits little antagonist
action on the receptors of monoamine such as adrenaline and serotonin.
(7) Noradrenaline-related Inhibitors
Product Name
CAS No.
Grade
Soluble in
IC50
Storage Condition
Summary
Maprotiline Hydrochloride, 98.0+ % (HPLC)
139-17091
1g
135-17093
5g
for Pharmacology
Research
10347-81-6
Methanol,
chloroform
IC50 = 8.4 nM
Keep at RT.
Tetracyclic antidepressant. It increases noradrenaline concentrations by inhibiting the reuptake of noradrenaline into the nerve terminals.
Mianserin Hydrochloride
132-16861
138-16863
50 mg
500 mg
for Pharmacology
Research
21535-47-7
Methanol
IC50 of α2 adrenaline receptor: 12 nM;
α adrenaline receptor: 300 nM;
5-HT receptor: 22 nM
Keep at RT.
Tetracyclic antidepressant. It blocks presynaptic α2 adrenaline autoreceptor, thereby accelerates noradrenaline release into synaptic gaps.
Acceleration of metabolic turnover of noradrenaline in the brain has also been reported. It exhibits 5-HT receptor blocking activity.
Mirtazapine, 98.0+ % (HPLC)
134-16821
130-16823
10 mg
50 mg
for Pharmacology
Research
85650-52-8
pKi = 6.9 - 7.0 (α2); 5.2 (5-HTA1);
Ethanol, methanol,
7.88 (5-HT2); 6.8, 8.1 (5-HT3);
chloroform
5.5 - 5.8 (NA uptake); ＜5.0 (5-HT uptake)
Keep at RT.
Noradrenergic and specific serotonergic antidepressant. Mirtazapine acts as an antagonist on presynaptic α2-adrenergic autoreceptors and
heteroreceptors and enhances noradrenaline and serotonin (5-HT) releases and adrenergic and serotonergic neurotransmission in the brain.
It also blocks 5-HT2 and 5-HT3 receptors and selectively activates 5-HT1A receptors.
(8) Alzheimer's Disease Research
Product Name
CAS No.
Soluble in
IC50
Storage Condition
290315-45-6
-
-
Keep at -20℃.
Grade
Summary
BMS 299897, 97.0+ % (HPLC)
021-17781
5 mg
027-17783
25 mg
for Cellbiology
Potent γ-secretase inhibitor that inhibits the formation of the amyloids Aβ40 and Aβ42 in vitro. It is also known not to inhibit Notch signaling.
It has oral activity.
DAPT, 97.0+ % (HPLC)
045-30981
5 mg
041-30983
25 mg
for Cellbiology
208255-80-5
Methanol
-
Keep at -20℃.
Water (1 mg/mL)
-
Keep at 2-10℃.
7. Neurotransmitter
Inhibitors
γ-secretase inhibitor.
Donepezil Hudrochloride, 90.0+ % (HPLC)
045-32321
50 mg
041-32323
250 mg
for Biochemistry
120011-70-3
Reversible acetylcholinesterase (AChE) inhibitor. Donepezil-induced downregulation of AChE leads to increased levels of acetylcholine in the
brain, which in turn stimulates cholinergic nerve system in the brain.
L-685, 458, 98.0+ % (HPLC)
121-06141
1 mg
for Cellbnioloty
292632-98-5
DMSO (>10 mg/mL)
-
Keep at -20℃.
Potent and selective γ-secretase inhibitor. It also inhibits with equal potency to Aβ40 and Aβ42 peptides.
30
Index
Product Name
PAGE
A
A-83-01 ················································· 1
AACOCF3 ············································ 25
17-AAG ·················································· 1
AG 1296 ················································ 1
AG 1478 ················································ 1
AG 490 ·················································· 1
ω-Agatoxin IVA ···································· 15
ω-Agatoxin TK ····································· 15
Agelenin ··············································· 15
Alendronate Sodium Salt Trihydrate ···· 14
ALK5 Inhibitor ········································ 1
AM 251 ················································ 26
AM 281 ················································ 26
AM 630 ················································ 26
AMG 9810 ··········································· 19
DL-2-Amino-4-phosphonobutyric Acid ··· 23
L-2-Amino-4-phosphonobutyric Acid ··· 23
D(-)-2-Amino-5-phosphonovaleric Acid ··· 23
DL-2-Amino-5-phosphonovaleric Acid ··· 23
Aminogenistein ······································ 1
Amitriptyline Hydrochloride ················· 27
Amlodipine ·········································· 16
Amoxapine ·········································· 27
Andrographolide ·································· 22
AP 18 ··················································· 20
Apamin ················································ 17
2-APB ·················································· 20
APETx2 ················································ 21
Apigenin ················································ 1
Aripiprazole ········································· 29
AS 604850 ············································· 1
AS 605240 ············································· 2
ATM Kinase Inhibitor ····························· 2
Azasetron Hydrochloride ····················· 27
B
BAY 11-7085 ······································· 22
BCTC ··················································· 20
Benazepril Hydrochloride ···················· 25
(+)-Bicuculline ······································ 26
(-)-Bicuculline Methobromide ·············· 26
(-)-Bicuculline Methochloride ·············· 26
Bio ························································· 2
(-)-Blebbistatin ····································· 14
Blonanserin ·········································· 27
BMS 299897 ········································ 30
6-Bromoindirubin-3'-oxime ··················· 2
Bupropion Hydrochloride ···················· 29
2,3-Butanedione Oxime ······················ 16
Butein ···················································· 2
C
Calcicludine ········································· 16
Calciseptine ········································· 16
Calpain Inhibitor 2 ······························· 14
Calphostin C ·········································· 2
Calyculin A ··········································· 12
Cantharidin ·········································· 12
Capsazepine ········································ 20
Captopril ·············································· 25
Carbonyl Cyanide
m-Chlorophenylhydrazone ················· 2
Charybdotoxin ····································· 17
DL-p-Chlorophenylalanine ·················· 27
8-(4-Chlorophenylthio)adenosine 3,5-(Cyclic)
monophosphate Sodium Salt ················· 22
Chlorotoxin ·········································· 21
Chlorpromazine Hydrochloride ············ 14
Cinnarizine ··········································· 16
Citalopram Hydrobromide ··················· 27
CKI-7 Dihydrochloride ··························· 2
Clomipramine Hydrochloride ··············· 27
Clotrimazole ········································ 19
Clozapine ············································· 29
Compound 15e ······································ 2
Compound 401 ····································· 2
α-Conotoxin G1 ··································· 21
μ-Conotoxin G3B ································ 19
μ-Conotoxin GS ·································· 19
ω-Conotoxin GVIA ······························· 16
α-Conotoxin ImI ··································· 21
α-Conotoxin M1 ·································· 21
ω-Conotoxin MVIIA ······························ 16
ω-Conotoxin MVIIC ····························· 16
α-Conotoxin S1 ··································· 21
μ-Conotoxin SIIIA ································ 19
ω-Conotoxin SVIB ······························· 16
(R)-CPP ················································ 23
Curcumin ············································· 22
Cyclopiazonic Acid ······························ 14
Cyclosporin A ······································ 12
E-64d ···················································
Enalaprilat Dihydrate ···························
Enalapril Maleate ·································
Evans Blue ···········································
14
25
25
24
F
Felbamate ············································
(±)-Fluoxetine Hydrochloride ··············
Fluphenazine Dimaleate ······················
Fluvoxamine Maleate ··························
Fostriecin Sodium Salt ························
24
28
14
28
12
G
Geldanamycin ······································· 3
Genistein ··············································· 3
Genistin ················································· 3
GF 109203X ··········································· 3
Glibenclamide ······································ 18
Gö 6983 ················································· 3
Granisetron Hydrochloride ·················· 28
GSK-3 Inhibitor IX ································· 2
GSK 269962A ········································ 3
GSK 429286A ········································ 4
GsMTx-4 ·············································· 21
Guangxitoxin-1E ·································· 18
H
H-1152 Dihydrochloride ························ 4
Haloperidol ·········································· 29
HC-030031 ·········································· 20
Herbimycin A ········································· 4
Huwentoxin-IV ····································· 19
Hypericin ··············································· 4
D
I
D-AP5 ·················································· 23
DL-AP5 ················································ 23
DAPT ··················································· 30
Deguelin ················································ 2
Dendrotoxin 1 ······································ 18
Desipramine Hydrochloride ················· 27
Dextromethorphan Hydrobromide
Monohydrate ······································ 23
Diazoxide ············································· 23
Dibucaine Hydrochloride ······················· 3
Diltiazem Hydrochloride ······················ 16
Disodium β-Glycerophosphate
Pentahydrate ····································· 12
2,5-Di-t-butylhydroquinone ················· 14
DL-AP7 ················································ 23
DNQX ·················································· 23
Donepezil Hudrochloride ····················· 30
Dorsomorphin ········································ 3
Dorsomorphin Dihydrochloride ············· 3
Doxepin Hydrochloride ························ 27
Duloxetine Hydrochloride ···················· 28
Iberiotoxin ············································ 18
IPA-3 ······················································ 4
Isotetrandrine ······································ 22
E
E-4031 n-Hydrate ································ 18
J
Joro Spider Toxin JSTX-3 ···················· 24
K
K-252a ··················································· 4
K-252b ··················································· 4
Kaliotoxin (1-37) ·································· 18
Kenpaullone ··········································· 4
Ki 8751 ·················································· 4
KN-62 ···················································· 5
KN-93 ···················································· 5
KN-93, Water-Soluble ··························· 5
KT 5720 ················································· 5
KT 5823 ················································· 5
KU 0063794 ··········································· 5
Kurtoxin ··············································· 17
L
L-685, 458 ··········································· 30
LDN 193189 Hydrochloride ··················· 5
31
Index
Product Name
PAGE
Levamisole Hydrochloride ··················· 12
Lisinopril Dihydrate ······························ 25
Loperamide Hydrochloride ·················· 24
LY-83583 ·············································· 22
LY 294002 ·············································· 5
Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-AlaPhe-Asp-Ala-Tyr ·································· 6
M
Maprotiline Hydrochloride ··················· 30
Margatoxin ··········································· 18
Mastoparan ········································· 15
MCD-Peptide ······································ 18
(+)-MCPG ············································ 24
Memantine Hydrochloride ··················· 24
3-Methyladenine ···································· 6
MG-132 ··············································· 15
MgTX ··················································· 18
Mianserin Hydrochloride ····················· 30
Milnacipran Hydrochloride ·················· 28
Mirtazapine ·········································· 30
(+)-MK 801 Maleate ····························· 24
N
NBQX ··················································· 24
NBQX Disodium Salt ··························· 24
Nicardipine Hydrochloride ··················· 17
Nitrendipine ········································· 17
NS2028 ················································ 22
NSC 693868 ·········································· 6
NU 7026 ················································ 6
NU 7441 ················································ 6
O
ODQ ····················································· 22
Olanzapine ··········································· 28
Olomoucine ··········································· 6
Olvanil ·················································· 20
Omeprazole ········································· 19
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin1-one ················································· 22
P
Paroxetine Hydrochloride ···················· 28
PD-98059 ·············································· 6
PD 173074 ············································· 6
PD 184352 ············································· 6
PD 0325901 ··········································· 7
Pentamidine Isethionate ······················ 24
Pentoxifylline ······································· 22
Perospirone Hydrochloride Dihydrate ··· 28
Phloretin ················································ 7
Phosphatase Inhibitor Cocktail Solution I ··· 13
Phosphatase Inhibitor Cocktail Solution II ··· 13
PI-103 ···················································· 7
Piceatannol ············································ 7
Picrotoxin ············································ 26
Picrotoxinin ·········································· 26
PIK-75 Hydrochloride ···························· 7
32
PKC 412 ················································ 7
PLTX-II ················································· 17
PP 2 ······················································ 7
PP 3 ······················································ 7
PP 242 ··················································· 7
Protease Inhibitor Cocktail Set I ·········· 13
Protease Inhibitor Cocktail Set III ········ 13
Protease Inhibitor Cocktail Set IV ········ 13
Protease Inhibitor Cocktail Set V ········· 13
Protease Inhibitor Cocktail Set VI ········ 13
Protease Inhibitor Cocktail Set VII ······· 13
ProTx-1 ················································ 17
ProTx-II ················································ 19
Psalmotoxin 1 ······································ 21
Purotoxin-1 ·········································· 21
Suramin Sodium ·································· 15
T
Tamoxifen Citrate ································ 10
Tautomycin ·········································· 12
Tertiapin ··············································· 18
TGF-β R I Kinase Inhibitor IV ················· 1
Thapsigargin ········································ 15
Tityustoxin Kα ······································ 19
Trazodone Hydrochrolide ···················· 29
Triciribine ············································· 10
TWS 119 ·············································· 10
Tyrphostin A25 ····································· 10
U
U 0126 ················································· 11
Q
Quercetin Dihydrate ······························ 8
Quetiapine Fumarate ··························· 28
Quinacrine Dihydrochloride Dihydrate 15
V
Venlafaxine Hydrochloride ··················· 29
Verapamil Hydrochloride ····················· 17
R
W
Rac1 Inhibitor ········································ 8
Radicicol ················································ 8
Rapamycin ············································ 8
RG-14620 ·············································· 8
Risperidone ········································· 29
RK-682 ················································ 12
RN-1747 ·············································· 20
Ro 31-8220 Methanesulfonate ·············· 8
Rolipram ·············································· 23
Roscovitine ············································ 8
Ruthenium Red ···································· 20
Ryanodine ··········································· 17
W-5 Hydrochloride ······························ 11
W-7 Hydrochloride ······························ 11
(+)-Wortmannin ···································· 11
Y
Y-27632 ··············································· 11
5 mmol/L Y-27632 Solution ················· 11
S
SB 202190 ············································· 8
SB 203580 ············································· 9
SB 203580 Hydrochloride ····················· 9
SB-366791 ·········································· 20
SB 415286 ············································· 9
SB 431542 ············································· 9
(+)-SCH23390 Hydrochloride ·············· 29
Scyllatoxin ··········································· 18
Sertraline Hydrochloride ······················ 29
SNX-482 ·············································· 17
SP 600125 ············································· 9
Spermine ············································· 25
D-erythro-Sphingosine ·························· 9
SR 3677 Hydrochloride ························· 9
Staurosporine ········································ 9
Stellettamide A Trifluoroacetate ············ 9
Stichodactyla Toxin ····························· 18
SU 4312 ··············································· 10
SU 5402 ··············································· 10
SU 5416 ··············································· 10
SU 6668 ··············································· 10
SU 11274 ············································· 10
(±)-Sulpiride ········································ 30

1. Kinase Inhibitors - wako

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