Product Catalog - Quanta BioDesign

Transcription

Product Catalog
Leading innovator, producer and provider of single molecure
discrete PEG (dPEG® ) derivatives
Fax your orders to 614 760-9781 or NEW: Order online at www.quantabiodesign.com
195 West Olentangy Street
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Suite O
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Powell, Ohio 43065
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Tel: 866 792-9222
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Fax: 614 760-9781
Last update 7/10
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[email protected]
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www.quantabiodesign.com
®
)
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Ordering Information
How do I order?
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Phone:
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Fax:
E-mail:
Website:
(866) 792-9222 or (614) 792-2958
Monday through Friday 9:00 am to 5:00 pm (EST)
(614) 760-9781 (24 hours, 7 days a week)
[email protected]
www.quantabiodesign.com
Ordering Information needed
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Company Name
Purchaser
Telephone and Fax number
E-mail Address for shipping confirmation
Shipping and Billing Addresses
P.O # and Credit Card Information
Orders can be placed via web, e-mail or fax
Payment
We accept MasterCard, Visa, American Express, USD check, and bank transfers. Some
international orders may require payment in advance. Our banking information will be on the
invoice. (Please do not send cash)
Shipping and Storage Details
Products will usually ship the same day as ordered, if it is received by 3:00pm EST. We ship all
products by Fedex overnight. Storage details will be shipped with each product. We
recommend storing Quanta BioDesign products in the freezer at -20° or in the refrigerator at
4° for long term storage. Orders outside the United States are shipped by Fedex International
Priority.
No products are shipped or delivered on weekends or U.S. holidays.
General Information
If you have a technical question about a product you received or have seen in the
catalog, please send an e-mail to [email protected] or call us at (614) 7922958 or (866) 792-9222.
Material Safety Data Sheets
MSDS’s are available on our website under each individual product. We can also fax or
e-mail a copy. Please mention your request on the order form if needed.
Product Analysis
Quanta BioDesign’s products are unique, single molecular weight (MW), discrete
PEG (dPEG™) compounds, synthesized de novo from pure, small units (e.g.,
triethylene glycol or tetraethylene glycol).Purity is assayed by HPLC, TLC, and/or
NMR.
Certificate of Analysis
A certificate of analysis (C of A) will be sent with your product(s) if requested. The C of
A provides the test method used, the results, and the purity level of the product.
Re-Stocking Fee
Due to the cost of re-qualifying product, there is a charge of $250 for each previously
un-opened vial/bottle that is returned. No previously opened product will be accepted.
Please note there are no returns on bulk quantity purchases.
Distributors
United States
Europe
India
Peptides International
Bio-Connect BV
Sri Lakshmi Bhargavi Pharma Pvt. Ltd.
11621 Electron Drive
Louisville, Kentucky 40299
Phone: 1-800-777-4779
Fax: (502)-267-1329
www.pepnet.com
VWR International
1310 Goshen Parkway
West Chester, PA 19380
Orders: 800-932-5000
www.vwr.com
Tim Tec, Inc.
100 Interchange Boulevard
Newark, Delaware 19711
Phone: (302) 292-8500
Fax: (302) 292-8520
[email protected]
www.timtec.net
Fisher Scientific
200 Park Lane Drive
Pittsburg, PA 15275
Phone: (800) 776-7000
Fax: (800) 926-5007
[email protected]
www.fishersci.com
Begonialaan 3a
6851 TE Hulssen
The Netherlands
Phone: +31 (0)326 4450
Fax: +31 (0)26 326 4451
[email protected]
www.bio-connect.nl
Stratech Scientific Limited
7 Acorn Business Centre Oak Dr.
Newmarket Suffolk
CB8 7SY United Kingdom
Phone: +44 (0) 1638-782600
Fax: +44 (0) 1638-782606
www.stratech.co.uk
Iris Biotech GmbH
Waldershofer Str. 51
95615 Marktredwitz
Germany
Phone: +49-(0)9231-9619-73
Fax: +49-(0)9231-9619-99
[email protected]
www.iris-biotech.de
Dynamic Diagnostics, Inc.
12665 Richfield Ct
Livonia, MI 48150
Phone: (800)-717-4677
Fax: (734)-425-5226
[email protected]
www.dynamicdiagnostics.com
Canada
BioVectra
11 Aviation Ave.
Charlottetown, PE C1E 2E6
Canada
Phone: 866-883-2873
Fax: 902-628-2045
www.biovectra.com
3 GF and 3, 4, 5 FF, SDF BLOCK II, EPIP
Pashamylaram – 502307
Patancheru (M), Medak Dist, AP, INDIA
Telefax: 011-91-8455-223699
[email protected]
www.srilbpharma.com
Australia
Stratech Scientific APAC Pty Ltd.
Sydney, Australia
Phone: +61 (0)2 9973 2421
Fax: +61 (0)2 9012 0019
[email protected]
www.startechscientific.com.au
Japan
Nacalai Tesque, Inc.
498 Higashitamaya-cho
Nijo Karasuma,Nakagyo-ku
Kyoto 604-0855 Japan
Phone: +81 75 251 1723
Fax: +81 75 251-1762
[email protected]
www.nacalai.com
Wako Pure Chemical Industries
1-2 Doshomachi 3-Chome
Chuo-ku
Osaka 540-8605
Phone: +81 6 6203 3741
Fax: +81 6 6201 5964
[email protected]
www.wako-chem.co.j
Terms and Conditions
Quanta BioDesign, Ltd. owns self-developed technologies, materials and information, as well
as accompanying patents, patent applications, know- how and practical knowledge for the
production of discrete polyethylene glycols, dPEG®s, and related products.
The following are standard terms of trade and are an integral part of all quotations and sales of
Quanta BioDesign, Ltd. to customers, buyers and business enterprises:
1. By placing a Purchase Order, the customer
accepts the standard Terms and Conditions
of Sale of Quanta BioDesign, Ltd. as
binding.
2. Payment terms of sale are net 30 days of
date of invoice, unless otherwise stated.
Credit Cards may not be used on past due
invoices.
3. Products sold are solely for use by qualified
individuals who are experts in their fields for
laboratory use only and are not intended to
be used for any other purposes, including
but not limited to, in vitro diagnostic
purposes, in foods, drugs, medical devices,
cosmetics or commercial use. Customer
represents and warrants to Quanta
BioDesign, Ltd. that Buyer will properly test,
manufacture, use and market any products
purchased from or materials produced from
products made or purchased from Quanta
BioDesign, Ltd. in strict compliance with all
applicable laws and regulations.
4. Nothing in terms of trade or quotation of
orders by Quanta BioDesign, Ltd. may be
interpreted such that they would result in
the assignment of rights of use by Quanta
BioDesign, Ltd. technology by the
customer.
5. A separate licensing agreement/supply
agreement between Quanta BioDesign,
Ltd. and its customer will be necessary for
the use of Quanta BioDesign, Ltd. products
in applications beyond laboratory use.
Customers are responsible to informing
Quanta BioDesign when products are being
used beyond lab use.
6. All goods must be inspected upon arrival
and may not be returned for credit except
with Quanta BioDesign, Ltd.’s permission.
Due to the cost of re-qualifying product,
there is a charge of $250 for each previously
un-opened vial/bottle that is returned. No
previously opened product will be
accepted. Please note there are no returns
on bulk quantity purchases.
7. Quanta BioDesign, Ltd.’s products are
subject to US export laws, treaties, rules
international agreements and regulations.
All
customers
purchasing
Quanta
BioDesign, Ltd.’s products assume the
responsibility of abiding by US export laws,
treaties, rules international agreements and
regulations along with applicable foreign
laws.
Please Note: International customers are responsible for any international customs, duties or taxes on
merchandise delivered to addresses outside the United States. These amount are not included in the
shipping charges shown on invoices and will be billed to the customer separately by the chosen carrier,
if applicable.
Table of Contents
0BBioconjugate Techniques.......................................................................................................................................................5
dPEG ® Drug Delivery and Drug Loading Reagents.................................. 6
Phospholipids ...................................................................................................................... 6
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m-dPEG®x-DSPE..........................................................................................................................................................6
m-dPEG®24-amido-dPEG®24-DSPE .............................................................................................................................6
TFP-dPEG®13-DSPE .....................................................................................................................................................7
MAL-dPEG®12-DSPE....................................................................................................................................................7
dPEG ® Based Chemical Modification Reagents ....................................... 9
Branched dPEG® PK/Serum Half-Life Modifiers .................................................................... 9
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MAL-dPEG®12 or 24-Tris(m-dPEG®x or-dPEG®y-acid)3 and 9 .......................................................................................9
Amino-dPEG®12 or 24-Tris(m-dPEG®x or-dPEG®y-acid)3 and 9 ..................................................................................10
Bis-MAL-Lysine-dPEG®4+12-Tris(m-dPEG®24 or-dPEG®24-acid)3 ...............................................................................11
Amine Reactive .................................................................................................................. 12
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m-dPEG®x-NHS ester ................................................................................................................................................12
m-dPEG®48-NH-CO(CH2)3 CO-TFP ester .................................................................................................................13
m-dPEG®x-amido dPEG®x-TFP ester........................................................................................................................13
m-dPEG®x-amido-dPEG®x acid.................................................................................................................................13
m-dPEG®x-acid ..........................................................................................................................................................14
NHS/TFP-dPEG®4-(m-dPEG®x)3-ester.......................................................................................................................15
Carboxyl-dPEG®4-(m-dPEG®X)3 .................................................................................................................................16
m-dPEG®x-alcohol .....................................................................................................................................................17
Carboxyl and Active Ester Reactive.................................................................................... 18
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m-dPEG®x-NHS carbonate .......................................................................................................................................18
m-dPEG®x-Propionaldehyde ....................................................................................................................................19
m-dPEG®x-amine.......................................................................................................................................................20
Amino-dPEG®x-acids.................................................................................................................................................21
Amino-dPEG®4-(m-dPEG®x)3 .....................................................................................................................................23
Carbonyl Reactive .............................................................................................................. 24
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Aminooxy-dPEG®12-amido- dPEG®12-(m-dPEG®11)3.................................................................................................24
Thiol and Sulfhydryl Reactive ............................................................................................. 25
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m-dPEG®x-MAL .........................................................................................................................................................25
MAL-dPEG®4-(m-dPEG®x)3 ........................................................................................................................................26
Other important reactivities............................................................................................... 27
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m-dPEG®x-Azide (Azido-m-dPEG®x).........................................................................................................................27
Metal Surface Modification Reagents (e.g., Au) ................................................................. 28
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Thiol-dPEG®x-acid .....................................................................................................................................................28
m-dPEG®x-Thiol.........................................................................................................................................................29
Lipoamido-dPEG®x-TFP ester ..................................................................................................................................30
Lipoamido-dPEG®x-acid ...........................................................................................................................................31
MAL and Biotin-dPEG®x-lipoamide .........................................................................................................................32
m-dPEG®x-Lipoamide ...............................................................................................................................................33
Reactivity: Converting an Amine to a Latent Thiol ............................................................. 34
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dPEG®x-SATA (S-acetyl-dPEG®x-NHS ester)............................................................................................................34
dPEG®x-SATA acid (S-acetyl-dPEG®x-acid)..............................................................................................................35
Reagents to extend Carboxyl with a dPEG® spacer............................................................ 36
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Amino-dPEG®x-t-butyl ester .....................................................................................................................................36
Amino-dPEG®x-methyl ester Prep KIT .....................................................................................................................37
Hydroxy-dPEG®x-t-butyl ester ..................................................................................................................................38
Amino-dPEG®x-alcohol .............................................................................................................................................39
t-boc-N-amido-dPEG®x-alcohol ...............................................................................................................................39
Azido-dPEG®x-alcohol ..............................................................................................................................................40
S-acetyl-dPEG®x-alcohol ...........................................................................................................................................41
dPEG®12-diol ..............................................................................................................................................................41
m-dPEG®x-tosylate ....................................................................................................................................................41
dPEG ® Based Crosslinking Reagents ...................................................... 43
Heterobifunctional Reagents: Amine and Thiol Reactive .................................................... 43
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4-formyl-benzamido-dPEG®x- TFP ester..................................................................................................................43
Phthalimidooxy-dPEG®x NHS ester .........................................................................................................................44
MAL-dPEG®x-NHS ester ...........................................................................................................................................45
MAL-dPEG®x-acid .....................................................................................................................................................46
MAL-dPEG®x-t-boc-hydrazide ..................................................................................................................................47
SPDP-dPEG®x-NHS ester ..........................................................................................................................................48
SPDP-dPEG®x-acid ....................................................................................................................................................49
Tris(2-carboxyethyl)phosphine hydrochloride (TCEP).............................................................................................50
Homobifunctional Reagents: Amine Reactive..................................................................... 51
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Bis-dPEG®x-NHS ester ..............................................................................................................................................51
Bis-dPEG®x-PFP & TFP esters ...................................................................................................................................53
Bis-dPEG®x-acid ........................................................................................................................................................55
Click Reagents: Azide ........................................................................................................ 56
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Azido-dPEG®x-NHS ester..........................................................................................................................................56
Azido-dPEG®x-acid....................................................................................................................................................57
Azido-dPEG®x-amine ................................................................................................................................................58
www.QuantaBioDesign.com
Tel. 866 792-9222
Fax 614 760-9781
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Click Reagents: Amine and Carboxyl Acetylide Partners .................................................... 59
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Propargyl-dPEG®1-NHS ester...................................................................................................................................59
Propargyl amine ........................................................................................................................................................59
Homobifunctional: Thiol Reactive....................................................................................... 60
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Bis-MAL-dPEG®x........................................................................................................................................................60
Homobifunctional: Diamine Monoprotected ...................................................................... 60
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t-boc-N-amido-dPEG®x-amine .................................................................................................................................60
Azido-dPEG®x-amine ................................................................................................................................................61
Diamido-dPEG®11-diamine .......................................................................................................................................61
CBZ-N-amido-dPEG®3-amine...................................................................................................................................62
t-boc-N-EDA .............................................................................................................................................................62
Miscellaneous: Homobifunctional; Monoprotected ............................................................ 63
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Acid-dPEG®x-NHS ester............................................................................................................................................63
Amino-dPEG®11-ONH-t-boc .....................................................................................................................................64
Bis-dPEG®5, half benzyl half NHS ester....................................................................................................................64
Thiol Reactive Miscellaneous without dPEG® ..................................................................... 65
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MPS (NHS-3-maleimidopropionate) ........................................................................................................................65
MPS-Acid ...................................................................................................................................................................65
MPS-EDA.TFA ...........................................................................................................................................................65
Bis-Maleimide amine, TFA salt.................................................................................................................................66
Bis-MAL-Lysine-dPEG®4-acid....................................................................................................................................67
Bis-MAL-Lysine-dPEG®4-TFP ester...........................................................................................................................68
Others................................................................................................................................ 69
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Amino-dPEG®x-t-boc-hydrazide...............................................................................................................................69
Fmoc-N-amido-dPEG®4-t-boc-hydrazide ................................................................................................................70
NHS-dPEG®4-t-boc-hydrazide ..................................................................................................................................70
dPEG ® Biotinylation Reagents................................................................. 71
Amine Reactive .................................................................................................................. 71
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NHS-dPEG®x-biotin...................................................................................................................................................71
dPEG®x-biotin acid ....................................................................................................................................................72
Biotin-dPEG®x-TFP ester...........................................................................................................................................73
NHS-S-S-dPEG®4-biotin ............................................................................................................................................74
TFP/NHS-dPEG®x-biotinidase resistant biotin ........................................................................................................75
Carbonyl Reactive .............................................................................................................. 76
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Biotin-dPEG®4-hydrazide ..........................................................................................................................................76
Biotin-dPEG®x-NH2 ....................................................................................................................................................77
Biotin-dPEG®x-oxyamine. HCl ..................................................................................................................................78
Biotin-dPEG®4-SS-NH-dPEG®3-ONH2.......................................................................................................................79
Tel. 866 792-9222
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Thiol Reactive .................................................................................................................... 80
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Biotin-dPEG®x-MAL...................................................................................................................................................80
Photoaffinity Biotinylation Reagents .................................................................................. 81
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Biotin-dPEG®3-benzophenone .................................................................................................................................81
Biotin-dPEG®3-TFPA .................................................................................................................................................81
Miscellaneous Biotinylation Reagents ................................................................................ 82
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Biotinoylsarcosine .....................................................................................................................................................82
Biotinoyl-2-Aminobutyric acid..................................................................................................................................82
Biotin-dPEG®x-azide..................................................................................................................................................83
NHS-biotin.................................................................................................................................................................84
Bis-dPEG®3-biotin......................................................................................................................................................84
Biotin-dPEG®3-cyanocobalamin ...............................................................................................................................84
dPEG ® based Fluorescent and other Dye Labels ................................... 87
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Lissamine Rhodamine B sulfonamide-dPEG®4-acid................................................................................................87
DNP-dPEG®x-NHS ester ...........................................................................................................................................87
DNP-dPEG®x-acid .....................................................................................................................................................88
Carboxy Fluorescein-dPEG®12-NHS ester................................................................................................................88
dPEG ® Based Reagents for Peptide Modification .................................. 89
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Fmoc-N-amido-dPEG®x-acid....................................................................................................................................89
Fmoc-N-amido-dPEG®x-NHS esters ........................................................................................................................90
Fmoc-N-Lys-(dPEG®x-biotin)-OH-(acid) ...................................................................................................................91
t-boc-N-amido-dPEG®x-acid ....................................................................................................................................92
Fmoc-amidooxy-dPEG®12 acid .................................................................................................................................93
Methoxytrityl-N-dPEG®x-acid ...................................................................................................................................94
Methoxytrityl-N-dPEG®x-TFP ester ..........................................................................................................................95
CBZ-N-amido-dPEG®x-acid ......................................................................................................................................96
Methoxytrityl-S-dPEG®x acid ...................................................................................................................................97
dPEG ® Reagents for Nucleic Acids ......................................................... 99
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Amino-dPEG®12-ODMT ............................................................................................................................................99
Please Note:
We make and offer many intermediates from which a range of otherwise
unavailable nucleic/oligonucleotides reagetns can be created.
Tel. 866 792-9222
Fax 614 760-9781
4
Bioconjugate Techniques
0B
A Tour de Force!
Buy it NOW!!
Greg has accomplished a Tour de Force with his new edition of
“Bioconjugate Techniques.” It is without a doubt the best
resource for those practicing in this broad field. He not only
teaches his theory, but also shows practical applications of his
theory. The book dicusses the latest advances in the field of
bioconjugates and is a great tool for those wishing to further
their understanding of biomolecules and bioconjugates. See
Chapter 18 for an introduction to the world of discrete PEG
(dPEG®). Thank you, Greg!
Buy a copy for only $90 or
get it FREE with an order of $1200 or more!
One book per customer.
Upon Request.
PLEASE NOTE: Book is shipped separately from products ordered.
Plesase allow 7-10 days for delivery .
Product #
Description
Price Per Book
10000
Bioconjugate Techniques by Greg T. Hermanson
$90
Tel. 866 792-9222
Fax 614 760-9781
5
dPEG® Drug Delivery and Drug Loading Reagents
Phospholipids
Phospholipids
m-dPEG®x-DSPE
Product #
Description
25 mg
100 mg
11024
m-dPEG ®8-DSPE
$125
$250
$125
$250
$125
$250
Mol. Wt.:1173.60; single compound; dPEG® Spacer is 26 atoms and 29.8 Å, Avg.
m-dPEG ®₁₂-DSPE
11025
Mol. Wt.:1349.81; single compound; dPEG® Spacer is 38 atoms and 44 Å, Avg.
m-dPEG ®24-DSPE
11026
m-dPEG®24-amido-dPEG ®24-DSPE
Product #
Description
m-dPEG
11027
®
®
24-amido-dPEG 24-DSPE
25 mg
100 mg
$125
$250
Tel. 866 792-9222
Fax 614 760-9781
6
Phospholipids
TFP-dPEG ®13-DSPE
Product #
Description
TFP-dPEG
11029
®
13-DSPE
25 mg
100 mg
$125
$400
25 mg
100 mg
$250
$600
Mol. Wt. 1599.96; single compound; dPEG® Spacer is 43 atoms and 50.0 Å, Avg.
MAL-dPEG®12-DSPE
Product #
Description
MAL-dPEG
11028
®
12 -DSPE
Mol. Wt.:1529.97; single compound; dPEG® Spacer is 46 atoms and 53.3Å, Avg.
References
1.
2.
3.
Gavin T. Noble, Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer, Ligand-targeted liposome design: challenges and
fundamental considerations, Trends in Biotechnology, 2014, 32(1), 32-45; http://dx.doi.org/10.1016/j.tibtech.2013.09.007.
Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer, Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased
Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length, ACSNano, 2013, 7(9), 8115-8127;
http://dx.doi.org/10.1021/nn4033954.
Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer, ASystematic Analysis of Peptide Linker Length and Liposomal
Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes, ACSNano, 2013, 7(4), 2935-2947; http://dx.doi.org/
10.1021/nn305663e.
Tel. 866 792-9222
Fax 614 760-9781
7
Tel. 866 792-9222
Fax 614 760-9781
8
dPEG® Based Chemical Modification Reagents
Branched dPEG® PK/Serum Half Life Modifiers
Branched dPEG ® PK/Serum Half-Life Modifiers
®
®
12
24
x
®
y
3
9
MAL-dPEG or -Tris(m-dPEG
or-dPEG -acid) and
Product #
Description
25 mg
100 mg
11471
MAL-dPEG®₁₂-Tris(m-dPEG®₂₄)₃
$250
$750
$350
$900
$450
$1100
$550
$1250
H
O N
O
O
N
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OO
O
O
O
O
O
O
N O O O O O O O O O O O O
O
O
O
O
O
O
N O
H O H H
O
O
O
O
O
O
N O O O O O O O O O O O O
O
O
O
O
O
O
O
Mol. Wt.: 4299.06; single compound; dPEG® Spacer is 127 atoms and 103.0 Å, Avg.
11451
MAL-dPEG®₁₂-Tris(-dPEG®₂₄-acid)₃
10484
MAL-dPEG®₁₂-Tris (dPEG®₁₂-Tris (m-dPEG®₁₁)₃)₃
11487
MAL-dPEG®₂₄-Tris (-dPEG®₂₄-Tris (m-dPEG®₂₄)₃)₃
Tel. 866 792-9222
Fax 614 760-9781
9
Amino-dPEG®12 or 24-Tris(m-dPEG®x
or-dPEG®y-acid)3 and 9
Product #
Description
25 mg
100 mg
11474
Amino-dPEG®₁₂-Tris(m-dPEG®₂₄)₃
$225
$700
$325
$800
$425
$1050
$525
$1200
11449
Amino-dPEG®₁₂-Tris(-dPEG®₂₄-acid)₃
10482
Amino-dPEG®₁₂-Tris (dPEG®₁₂-Tris (m-dPEG®₁₁)₃)₃
11486
Amino-dPEG®₂₄-Tris (-dPEG®₂₄-Tris (m-dPEG®₂₄)₃)₃
Tel. 866 792-9222
Fax 614 760-9781
10
Bis-MAL-Lysine-dPEG ®4+12Tris(m-dPEG®24 or-dPEG®24-acid)3
Product #
Description
25 mg
100 mg
11633
Bis-MAL-Lysine-dPEG® 4-dPEG®12-Tris(m-dPEG®₂₄)₃
$225
$700
$325
$900
Mol. Wt.: 4825.69; single compound; dPEG® Spacer are atoms 149 and 153; 110.3 and 112.5 Å, Avg.
11630
Bis-MAL-Lysine-dPEG® 4-dPEG®12-Tris(-dPEG®₂₄-acid)₃
Mol. Wt.:
4999.80; single compound; dPEG® Spacer is 152 and 156 atoms and 113.0 and 115.4 Å, Avg.
Tel. 866 792-9222
Fax 614 760-9781
11
Amine Reactive
Amine Reactive
m-dPEG®x-NHS ester
O
NH2
+
NHS-dPEG®x-m
=
dPEG®X-m
N
H
Antibody (reduce non-s pecific binding); Drug/protein (increased
solubility)
Product #
Description
100 mg
1000 mg
10327
m-dPEG ®2-NHS ester
$100
$300
$100
$400
$175
$500
$175
$600
$225
$1250
$325
$1500
$400
$1700
O
O
O
O
O
N
O
Mol. Wt.: 245.23; single compound; dPEG® Spacer is 8 atoms and 8.5 Å
10211
O
O
O
O
O
O
O
N
O
10260
10262
10304
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
Mol. Wt.: 1214.39; single compound; dPEG Spacer is 74 atoms and 86.2 Å
®
10910
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
ON
O
10920
Additional Reference for these products can be located at the end of this Category.
Tel. 866 792-9222
Fax 614 760-9781
12
Amine Reactive
m-dPEG®48-NH-CO(CH2)3 COTFP ester
Product #
Description
100 mg
1000 mg
10143
m-dPEG ®48-NH-CO(CH2)3CO-TFP ester
$375
$1600
m-dPEG®x-amido dPEG®x-TFP ester
Product #
Description
10149
m-dPEG
®
®
12-amido-dPEG 12-TFP
100 mg
1000 mg
$275
$1300
$400
$1700
100 mg
1000 mg
$250
$1100
$400
$1700
ester
Mol. Wt.:1336.45; single compound; dPEG® Spacer is 77 atoms and 91.3 Å
m-dPEG ®24-amido-dPEG®24-TFP ester
10144
m-dPEG®x-amido-dPEG ®x acid
Product #
10148
Description
m-dPEG
®
®
12-amido-dPEG 12-acid
10147
m-dPEG ®24-amido-dPEG®24-acid
Mol. Wt.:2245.68; single compound; dPEG® Spacer is 150 atoms and 177 Å
Tel. 866 792-9222
Fax 614 760-9781
13
Amine Reactive
m-dPEG®x-acid
O
NH 2
+
NHS-dPEG ®x-m
=
dPEG®X-m
N
H
Antibody (reduce non-s pecific binding); Drug/protein (increased solubility)
Product #
Description
100 mg
1000 mg
10326
m-dPEG ®2-acid
$100
$250
$100
$300
$175
$400
$175
$515
$225
$1000
$325
$1500
$400
$1700
O
O
O
OH
m-dPEG ®4-acid
10234
O
O
O
O
O
OH
m-dPEG ®8-acid
10324
O
O
O
O
O
O
O
O
O
OH
m-dPEG ®12-acid
10328
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
m-dPEG ®24-acid
10339
m-dPEG ®37-acid
10909
m-dPEG ®48-CO(CH2)3-acid
10142
Tel. 866 792-9222
Fax 614 760-9781
14
Amine Reactive
NHS/TFP-dPEG ®4-(m-dPEG®x)3-ester
NH 2 +
dPEG ®y
NHS
dPEG®X-m
dP EG®X-m
O
dP EG®X-m
O
NH
dPEG ®y
dP EG®X-m
=
dPEG®X-m
dP EG®X-m
Antibody (reduce non-specific binding); Drug/protein (increase solubility)
Product #
Description
100 mg
1000 mg
10411
NHS-dPEG®4-(m-dPEG®4)3-ester
$250
$1300
$250
$1300
$250
$1300
$250
$1300
$350
$1575
$350
$1575
10421
TFP-dPEG®4-(m-dPEG ®11)3-ester
11401
Mol. Wt.; 2339.62; single compound; dPEG® Spacer is 63 atoms and 74.1 Å, Avg.
10401
Mol. Wt.; 2420.80; single compound; dPEG® Spacer is 66 atoms and 51.1 Å, Avg.
10454
. Mol. Wt.: 4006.69; single compound; dPEG® Spacer is 103 atoms and 107.1 Å, Avg.
TFP-dPEG®4-(m-dPEG ®24)3-ester
10458
. Mol. Wt.: 4057.72; single compound; dPEG® Spacer is 103 atoms and 107.1 Å, Avg.
References:
GregT. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0)., Ch. 18, pp.
711-742.
Tel. 866 792-9222
Fax 614 760-9781
15
Amine Reactive
Carboxyl-dPEG ®4-(m-dPEG ®X)3
Product #
10412
Description
100 mg
1000 mg
Carboxyl-dPEG®4-(m-dPEG®4)3
$250
$1300
$250
$1300
$250
$1300
$250
$1300
$350
$1575
Mol. Wt.: 1266.47; single compound; dPEG® Spacer is 43 atoms and 28 Å, Avg.
10422
11402
10402
10455
Tel. 866 792-9222
Fax 614 760-9781
16
Amine Reactive
m-dPEG®x-alcohol
Product #
Description
100 mg
1000 mg
10348
m-dPEG ®4-alcohol
$75
$250
$50
$200
$100
$250
$150
$350
$175
$500
$200
$600
$350
$1000
m-dPEG ®7-alcohol
10251
m-dPEG ®11-alcohol
10252
O
O
O
O
O
O
O
O
O
O
O
OH
m-dPEG ®15-alcohol
10894
m-dPEG ®19-alcohol
10895
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
O
®
m-dPEG ®23-alcohol
10942
m-dPEG ®36-alcohol
10728
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Tel. 866 792-9222
Fax 614 760-9781
17
Carboxyl and Active Ester Reactive
m-dPEG®x-NHS carbonate
O
O
NH2
+
=
O-dPEG ®x-m
NHS
(potentially cleavable)
O-dPEG ®x-m
N
H
Antibody (r educe non-specific binding); Drug/pr otein (increase solubility)
Product #
Description
100 mg
1000 mg
10305
m-dPEG ®3-NHS carbonate
$100
$500
$150
$650
$165
$850
$225
$950
$300
$1050
$325
$1200
10929
10307
10898
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
10899
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
10930
Tel. 866 792-9222
Fax 614 760-9781
18
m-dPEG®x-Propionaldehyde
O
NH 2
+
O
+
w/ reductive amination
NHNH2
=
Stab le
O
O
H
dPEG ®x-m
HN
dPEG ®x-m
H
N
H
dPEG ®x-m
N
dPEG®x-m
A cid labile
Antibody (reduce non-specific binding); Drug/protein (increased solubility)
Product #
Description
10362
m-dPEG ®4-Propionaldehyde
100 mg
1000 mg
$100
$600
$100
$600
$175
$900
$225
$1200
O
O
O
O
O
H
Mol. Wt. 220.26; single compound; dPEG® Spacer is 14 atoms and 16.5 Å
10363
10424
M.W. 572.68; single compound; dPEG® Spacer is 38 atoms and 44.0 Å
10364
Tel. 866 792-9222
Fax 614 760-9781
19
m-dPEG®x-amine
Product #
Description
100 mg
1000 mg
10175
m-dPEG ®4-amine
$125
$325
$175
$500
$200
$700
$225
$1025
$250
$1125
$300
$1250
$350
$1325
m-dPEG ®8-amine
10278
O
O
O
O
O
O
O
O
NH2
m-dPEG ®12-amine
10288
O
O
O
O
O
O
O
O
O
O
O
O
NH2
m-dPEG ®15-amine
10298
m-dPEG ®24-amine
10318
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
NH2
m-dPEG ®36-amine
10908
m-dPEG ®48-amine
10918
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0).
Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Tel. 866 792-9222
Fax 614 760-9781
20
Amino-dPEG ®x-acids
Product #
Description
100 mg
1000 mg
10244
Amino-dPEG®4-acid
$100
$350
$100
$450
$175
$500
$195
$800
10067
Amino-dPEG®6-acid
10277
Amino-dPEG®8-acid
10287
Amino-dPEG®12-acid
Tel. 866 792-9222
Fax 614 760-9781
21
Amino-dPEG ®x-acids (cont.)
Product #
Description
100 mg
1000 mg
10317
Amino-dPEG®24-acid
$250
$1250
$300
$1400
Mol. Wt.: 1146.35; single compound; dPEG® Spacer is 76 atoms and 89 Å
Amino-dPEG®36-acid
10907
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter
14, pp. 582-626. Many of these can be applied to surfaces as well as particles, as Greg has emphasized in this chapter. A great picture of an optimal chemistry is shown
in his Figure 14.5, pg. 591. The example uses them in conjunction with the m-dPEG®x amines, generally equal to or shorter than the amino-dPEG® acid.
Tel. 866 792-9222
Fax 614 760-9781
22
Amino-dPEG ®4-(m-dPEG ®x)3
dPEG ®X-m
O
NHS (OH)
+
H2N
dP EG®y
dPEG ®X-m
dPEG ®X-m
O
NH
dPEG®y
dPEG ®X-m
=
dPEG ®X-m
dPEG ®X-m
Antibody (r educe non-specific binding); Drug/protein (increase solubility)
Product #
Description
100 mg
1000 mg
10410
Amino-dPEG®4-(m-dPEG ®4)3
$250
$1300
$250
$1300
$250
$1300
$250
$1300
$325
$1575
10420
NH2-dPEG®4-(m-dPEG®11)3-ester
11400
Mol. Wt.: 2077.47; single compound; dPEG® Spacers are 58 atoms and 64.63 Å, Avg.
10400
Mol. Wt.: 2209.63; single compound; dPEG® Spacers are 61 atoms and 63 Å, Avg.
10453
Mol. Wt.: 3795.52; single compound; dPEG® Spacers are 97 atoms and 96.2(avg) Å, Avg.
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 1,
pp. 25.
Tel. 866 792-9222
Fax 614 760-9781
23
CarboxylReactive
Carbonyl Reactive
Aminooxy-dPEG®12-amidodPEG®12-(m-dPEG®11)3
Aldehydes (latent) are common
in carbohydrates, carbohydrate
containing proteins, in oxidizable
matrices, among others AND can
be incorporated using reagents
like the 4-FB-dPEG®x TFP esters
(amine reactive)
Aminooxy-dPEG®s with a
LABEL. Quanta has available a
BIOTIN label. PN 11112 below is
perfect for making your own.
Product #
Description
100 mg
1000 mg
10492
Aminooxy-dPEG®12-amido-dPEG®12-(m-dPEG ®11) 3
$350
$2000
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0)., See pp.
276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SPDP and LC-SPDP on pp. 286-288. See Greg’s
extensive index on pg. 1192-1193 for references to a number and range of applications and their respective protocols.
Tel. 866 792-9222
Fax 614 760-9781
24
Thiol and Sulfhydryl Reactive
m-dPEG®x-MAL
O
SH
+
N m-dPEG®x
S
m-dPEG®x-MAL
O
= antibody fragment; cystine terminated peptide; protein with thiol, natural or engineered; small molecule;
soluble and hydrophilic alternative to NEM
Product #
Description
10745
m-dPEG ®4-MAL
100 mg
1000 mg
$200
$650
$225
$900
$250
$1125
$275
$1300
$350
$1400
$425
$1500
O
O
O
O
O
H
N
N
O
O
Mol. Wt.: 360.40; single compound; dPEG® Spacer is 20 atoms and 22.1Å
m-dPEG ®8-MAL
10746
m-dPEG ®12-MAL
10289
m-dPEG ®24-MAL
10319
m-dPEG ®36-MAL
10931
m-dPEG ®48-MAL
10932
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See all of
the extensive references to the reactions of maleimides with a wide variety of compounds and applications, Hermanson, pg. 1174 (index for malemides) and references
therein.
Tel. 866 792-9222
Fax 614 760-9781
25
MAL-dPEG ®4-(m-dPEG ®x)3
O
O
+
SH
dPEG ®X-m
dPEG®y
N
S
dPEG®X-m
=
dPEG®X-m
dPEG ®X-m
O
dPEG ®X-m
O
dPEG ®X-m
dPEG®y
N
Antibody (reduce non-specific binding); Drug/protein (increase solubility)
Product #
Description
100 mg
1000 mg
10416
MAL-dPEG ®4-(m-dPEG®4)3
$250
$1300
$250
$1300
$250
$1300
$250
$1300
$350
$1575
10426
O
O
O
N
N
H
O
O
O
O
O
O
H
N
O
N
H
O
O
O
O
O
N
H
O
H
N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
M.W. 1832.12; single compound; dPEG® Spacer is 55 atoms and 61.9 Å, Avg.
11406
10406
10456
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Ch. 1, Pg.
30
Tel. 866 792-9222
Fax 614 760-9781
26
Other important reactivities
Other important reactivities
m-dPEG ®x-Azide (Azido-m-dPEG ®x)
(reduce)
m-dPEG ®x-N3
m-dPEG ®x-NH 2
Cu(I)
+
=
N
m-dPEG ®x-N3
dPEG®x-m
N N
Small molecule; modified surface; peptide, oligo
Product #
Description
100 mg
1000 mg
10532
m-dPEG ®4-Azide (Azido-m-dPEG ®4)
$125
$500
$175
$600
$225
$700
$275
$800
$300
$1000
O
O
O
N3
O
®
10534
10536
m-dPEG ®24 Azide (Azido-m-dPEG ®24)
10540
m-dPEG ®36 Azide (Azido-m-dPEG ®36)
10531
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N3
Tel. 866 792-9222
Fax 614 760-9781
27
Metal Surface Modification Reagents (e.g., Au)
Thiol-dPEG®x-acid
HO O
x
dP
EG ®
x
®
G
dPE
O OH
Metal
Par ticle,
e.g., Au
O
+
X
HS
O
HO dP
EG ®
x
S
S
Metal
Particle,
e.g., Au
dPEG®x OH
O
x
S
®
EG
dP
S d
PE
S
OH
x
G®
x
O
OH
S
dP EG ®
HO
®
EG
dP
O
S
x
HO
O
Product #
Description
100 mg
1000 mg
10247
Thiol-dPEG®4-acid
$200
$500
$250
$700
$250
$900
Thiol-dPEG®8-acid
10183
Thiol-dPEG®12-acid
10850
Mol. Wt.: 634.77; single compound; dPEG® Spacers are 39 atoms and 46.8 Å
References:
Tel. 866 792-9222
Fax 614 760-9781
28
m-dPEG®x-Thiol
x
dP
EG ®
x -m
®
G
PE
m -d
S
m -d
P EG®
S
x
Metal
Particle,
e.g., Au
X
+
HS
Metal
Particle,
e.g., Au
dPEG®x-m
Product #
Description
10792
m-dPEG ®4-Thiol
O
O
O
® x-m
EG
dP
S d
PE
S
x
S
G®
x -m
S
dPEG ®
xm
m
®
G
PE
-d
S
100 mg
1000 mg
$150
$400
$200
$600
$250
$900
SH
O
m-dPEG ®8-Thiol
10793
O
O
O
O
O
O
O
SH
O
m-dPEG ®12-Thiol
10794
O
O
O
O
O
O
O
O
O
O
O
O
SH
References:
Tel. 866 792-9222
Fax 614 760-9781
29
Lipoamido-dPEG ®x-TFP ester
Product #
Description
100 mg
1000 mg
10641
Lipoamido-dPEG ®4-TFP ester
$200
$800
$250
$1150
$300
$1250
$400
$1400
10642
10814
10643
Tel. 866 792-9222
Fax 614 760-9781
30
Lipoamido-dPEG ®x-acid
Product #
Description
10806
Lipoamido-dPEG ®4-acid
O
O
N
H
S S
1000 mg
$200
$800
$250
$1150
$300
$1250
$400
$1400
O
O
O
100 mg
O
OH
10807
O
O
O
N
H
S S
O
O
O
O
O
O
O
OH
10808
O
O
N
H
S S
O
O
O
O
O
O
O
O
O
O
O
O
OH
10811
O
S S
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 1334.66; single compound; dPEG® Spacer is 83.5 atoms and 99.0 Å
References:
Greg T. Hermanson. Bioconjugate Techniques, 2nd edition. Elsevier, Inc., Burlington, MA 01803, April 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pages
188-190, 485-497, 924-935
Tel. 866 792-9222
Fax 614 760-9781
31
MAL and Biotin-dPEG ®x-lipoamide
MAL O
O MAL
x
dP
EG ®
x
®
G
dPE
Maleimide provides functionality for antibody immobilization,
as well as peptides, oligos, etc.!!
LA
O
MAL dP
EG ®
O
Metal
Particle,
e.g., Au, Ag
QD, magn.
X
+
LA
x
LA =
LA
x
Metal
Particle,
e.g., Au, Ag
QD, magn.
N
dPEG®
O
O
O
S S
MAL
O
x
LA
O
MAL
biotin O
x
dP
EG ®
x
®
G
dPE
O biotin
LA
O
biotin dP
EG ®
X
+
biotin
x
LA
Metal
Particle,
e.g., Au, Ag
QD, magn.
LA
O
®
EG
dP
LA d
PE
biotin
x
G®
LA
x
O
bio tin
LA
dP EG ®
®
EG
dP
O
O
LA =
LA
x
O
dPEG®x biotin
LA
LA d
PE ® O
G
x MAL
x
O
Biotin opens the door to binding streptavidin derivatives!
Metal
Particle,
e.g., Au, Ag
QD, magn.
MAL
x
LA
N
MAL =
LA
O
®
EG
dP
dP EG ®
®
EG
dP
LA
x
S S
biotin
Product #
O
Description
MAL-dPEG ®3-Lipoamide
10817
O
O
O
O
N
H
S S
O
100 mg
1000 mg
$225
$900
$325
$1100
$250
$975
$350
$1250
$450
$1250
O
N
H
N
O
MAL-dPEG ®11-Lipoamide
10819
O
O
N
H
S S
O
O
O
O
O
O
O
O
O
O
O
O
N
H
N
O
Biotin-dPEG ®3-Lipoamide
10820
O
O
S
S
O
O
N
H
O
HN
O
NH
N
H
S
10822
O
O
S S
N
H
O
O
O
O
O
O
O
O
O
O
O
N
H
HN
O
NH
S
10828
References:
188-190, 485-497, 924-935
Tel. 866 792-9222
Fax 614 760-9781
32
m-dPEG®x-Lipoamide
dP
E
x
G®
x -m
®
G
PE
m -d
Lipoamide vs. thiol- produces HIGHER binding to metal!
LA
m-d
P EG®
X
+
LA
dPEG ®x-m
O
®
G
PE
-d
x
LA
Metal
Particle,
e.g., Au, Ag
QD, magn. LA
® x-m
EG
dP
dP
EG ®
x -m
LA
dPEG ®
xm
m
LA =
LA
LA
x
Metal
Particle,
e.g., Au, Ag
QD, magn.
LA
S S
Product #
Description
100 mg
1000 mg
10799
m-dPEG ®4-Lipoamide
$150
$700
$200
$1000
$300
$1150
$400
$1300
O
S
O
N
H
S
O
O
O
10800
O
O
N
H
S S
O
O
O
O
O
O
O
Mol. Wt.: 571.79; single compound; dPEG® Spacer is 34.5 atoms and 38.8 Å
10801
O
O
N
H
S S
O
O
O
O
O
O
O
O
O
O
O
10804
O
SS
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
®
References:
188-190, 485-497, 924-935
Tel. 866 792-9222
Fax 614 760-9781
33
Reactivity: Converting an Amine to a Latent Thiol
dPEG®x-SATA (S-acetyl-dPEG ®x-NHS ester)
O
NH 2
+
O
N
H
dPEG®X-SH
+
N
H
N
S
R emove a cetyl with H 2 NOH
dPEG®X-SH
O
HS
S
O
= small molecule --> biologicals
O
O
NHS-dPEG ®xS
-
N
Fabulous Conjugates!!!
O
Some op tions; availab le
with dPEG ®
x
Product #
Description
100 mg
1000 mg
10181
dPEG®4-SATA (S-acetyl-dPEG ®4-NHS ester)
$235
$1250
$350
$1250
$400
$1300
$550
$1600
dPEG®8-SATA (S-acetyl-dPEG ®8-NHS ester)
10184
dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester)
10852
dPEG®24-SATA (S-acetyl-dPEG®24-NHS ester)
10188
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). References
to SATA, which can be directly applied to the dPEG® pegylation versions: a) general description and use, pg. 71; b) modification of antibodies, pg. 795; c) modification
of amines on nucleotides and DNA probes, pg. 984 ; and d) modification of enzymes, avidin and streptavidin with, pg. 90,909, and 919.
Tel. 866 792-9222
Fax 614 760-9781
34
dPEG®x-SATA acid (S-acetyl-dPEG ®x-acid)
O
NH 2
+
O
N
H
dP EG®X-SH
+
N
H
N
S
Remove a cetyl with H 2NOH
dPEG®X-S
O
HS
S
O
= small molecule --> biologicals
O
O
NHS-dPEG ®xS
-
N
Fabulous Conjugates!!!
O
So me op tions; availab le
with dPEG ®
x
Product #
Description
100 mg
1000 mg
10180
dPEG®4-SATA acid (S-acetyl-dPEG ®4-acid)
$215
$1175
$215
$1175
$350
$1250
$500
$1550
10182
dPEG®8-SATA acid (S-acetyl-dPEG ®8-acid)
10851
dPEG®12-SATA acid (S-acetyl-dPEG®12-acid)
Mol. Wt.: 676.81 single compound; dPEG® Spacer is 39 atoms and 46.8 Å
10208
dPEG®24-SATA acid (S-acetyl-dPEG®24-acid)
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). References
to SATA, which can be directly applied to the dPEG® pegylation versions: a) general description and use, pg. 71; b) modification of antibodies, pg. 795; c) modification
of amines on nucleotides and DNA probes, pg. 984 ; and d) modification of enzymes, avidin and streptavidin with, pg. 90,909, and 919.
Tel. 866 792-9222
Fax 614 760-9781
35
Reagents to extend Carboxyl with a dPEG® spacer
®
Reagents to extend Carboxyl with a dPEG spacer
Amino-dPEG ®x-t-butyl ester
O
O
+
NHS
NH2-dPEG®x-t-butyl
NH-dPEG ®x -t-butyl ester
ester
= any small molecule or activated biological, as acid (activatable in situ) or activated ester, e.g., NHS ester
Product #
Description
100 mg
1000 mg
10264
Amino-dPEG®2-t-butyl ester
$100
$350
$135
$700
$135
$700
$175
$800
O
O
H2N
O
O
10221
10061
O
O
H2 N
O
O
O
O
O
O
®
10271
10281
$225
$900
$250
$1200
10311
10901
H2 N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
$300
O
O
O
O
O
O
O
O
O
O
O
O
$1400
O
O
O
®
Tel. 866 792-9222
Fax 614 760-9781
36
Amino-dPEG ®x-methyl ester Prep KIT
Product #
Description
100 mg
1000 mg
10330
Amino-dPEG®4-methyl ester Prep KIT
$150
$800
$200
$900
$200
$925
$225
$1050
$325
$1500
10331
O
H 2N
O
O
O
O
O
O
OCH3
10332
10334
10337
Tel. 866 792-9222
Fax 614 760-9781
37
Hydroxy-dPEG ®x-t-butyl ester
Product #
Description
10223
Hydroxy-dPEG®4-t-butyl ester
100 mg
1000 mg
$100
$350
$125
$500
$150
$550
$200
$650
$300
$1050
O
O
HO
O
O
O
O
10717
10185
10719
O
HO
O
O
O
O
O
O
O
O
O
O
O
O
O
10722
HO
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
Tel. 866 792-9222
Fax 614 760-9781
38
Amino-dPEG ®x-alcohol
Product #
Description
100 mg
1000 mg
10249
Amino-dPEG®4-alcohol
$100
$250
$150
$650
$200
$850
$250
$1100
$350
$1400
10240
10170
O
H2N
O
O
O
O
O
O
O
O
O
O
OH
10868
H 2N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 1074.29; single compound; dPEG® Spacers are 71 atoms and 86.0 Å.
10869
H2N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 1602.92; single compound; dPEG® Spacers are 107 atoms and 129 Å.
t-boc-N-amido-dPEG ®x-alcohol
Product #
Description
100 mg
1000 mg
10250
t-boc-N-amido-dPEG®4-alcohol
$100
$500
$225
$900
t-boc-N-amido-dPEG®12-alcohol
10171
O
O
N
H
O
O
O
O
O
O
O
O
O
O
O
OH
Tel. 866 792-9222
Fax 614 760-9781
39
Azido-dPEG ®x-alcohol
Click:
+
Cu(I)
N 3-dPEG®x-OH
e.g., Dmt-Cl
N
(reduction)
N 3-dPEG®x-O-Dmt
N3-dPEG ®x-OH
Product #
Description
10541
Azido-dPEG®4-alcohol
HO
O
O
N
-dPEG ®x-OH
N
NH2 -dPEG®x-O-Dmt
100 mg
1000 mg
$150
$200
$200
$500
$225
$600
$325
$1000
$350
$1100
N3
O
Mol. Wt.: 219.24; single compound; dPEG® Spacers are 14 atoms and 15.3 Å.
10542
10340
HO
O
O
O
O
O
O
O
O
O
O
O
N3
10543
10544
Tel. 866 792-9222
Fax 614 760-9781
40
S-acetyl-dPEG ®x-alcohol
Product #
Description
100 mg
1000 mg
10156
S-acetyl-dPEG ®4-alcohol
$100
$500
$150
$650
$200
$800
10160
10939
dPEG®12-diol
Product #
Description
100 mg
1000 mg
10261
dPEG®12-diol
$125
$750
m-dPEG®x-tosylate
Product #
Description
1000 mg
10254
m-dPEG ®2-tosylate
$200
m-dPEG ®4-tosylate
10256
$300
m-dPEG ®7-tosylate
10259
O
O
O
O
O
$400
O
O
OTs
Tel. 866 792-9222
Fax 614 760-9781
41
References
MAL-dPEG®x-(dPEG®x-acid)x
1.
Site specific discrete PEGylation of 124I-labeled mCC49 Fab’ fragments improves tumor microPET/CT imaging in mice. Haiming Ding,
Michelle M Carleton, Stephen P Povoski, Keisha Milum, Krishan Kumar, Kothandaraman Shankaran, George H Hinkle, David Colcher, Rich
Brody, Paul D Davis, Alexander Pokora, Mitchell Phelps, Edward W. Martin, and Michael F. Tweedle. Bioconjugate Chemistry. 2013, October
4, 2013. DOI: 10.1021/bc400375f.
Bis-MAL-Lysine-dPEG®x-acid
1.
Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung
Kim, Hai Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee, Bioconjugate Chem.,
2011, 22 (4), pp 625–632 March 14, 2011. DOI: 10.1021/bc100404x.
m-dPEG ®x-NHS ester
1.
Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson, Andrew M. Dattelbaum, Harshini Mukundan,
Dominique N. Price, W. Kevin Grace, Basil I. Swanson. Spie Digital Library, 2010, 7553. January 23, 2010. DOI: 10.1117/12.809383.
2.
Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces.
Marie J. Archer, Jinny L. Liu. Sensors. 2009, 9 pp 6298-6311. August 12, 2009. DOI: 10.3390/s90806298
3.
Bioconjugation of Ln3+-Doped LaF3 Nanoparticles to Avidin. Peter R. Diamente, Robert D. Burke, and Frank C. J. M. van Veggel. Langmuir.
2006, 22 (4) pp 1782–1788. December 30, 2005. DOI: 10.1021/la052589r.
4.
Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki,
Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.
5.
Self-Assembly of Solid-Supported Membranes Using a Triggered Fusion of Phospholipid-Enriched Proteoliposomes Prepared from the Inner
Mitochondrial Membrane. Ce´line Elie-Caille, Ophe´lie Fliniaux, Jacques Pantigny,Jean-Claude Mazie`re, and Christian Bourdillon. Langmuir.
2005, 21 (10) pp 4661–4668. April 7, 2005. DOI: 10.1021/la046973k.
6.
N-Alkylated aminopyrazines for use as hydrophilic optical agents. Amruta R. Poreddy, Bethel Asmelash, Karen P. Galen, Richard M. Fitch,
Jeng-Jong Shieh, James M. Wilcox, Tasha M. Schoenstein, Jolette K. Wojdyla, Kimberly R. Gaston, John N. Freskos, William L. Neumann,
Raghavan Rajagopalan, Hyo-Yang Ahn, James G. Kostelc, Martin P. Debreczeny, Kevin D. Belfield, and Richard B. Dorshow. Proc. SPIE.
Nanoparticles, and Molecular Probes for Biomedical Applications. 2009. 71900. February 20, 2009. doi:10.1117/12.809287.
7.
Reconstitution of the M13 Major Coat Protein and Its Transmembrane Peptide Segment on a DNA Template. Weijun Li, Itai Suez and Francis
C. Szoka, Jr. Biochemistry. 2007, 46 (29) pp 8579–8591. June 27, 2007. DOI: 10.1021/bi700165m
8.
Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope.
Hoyin Mok, Sujin Lee, David W. Wright, and James E. Crowe Jr. Vaccine. 2008, 26 (37) pp 4775-4782. September 2, 2008. DOI:
10.1016/j.vaccine.2008.07.012.
9.
Electrostatic readout of DNA microarrays with charged microspheres. Nathan G Clack, Khalid Salaita, Jay T Groves. Nature Biotechnology.
2008, 26 (7) pp 825-830. June 29, 2008. DOI: 10.1038/nbt1416.
10.
Poly(ethylene oxide)-bonded stationary phase for capillary ion chromatography. Toyohide Takeuchi, Budhi Oktavia, Lee Wah Lim. Anal
Bioanal Chem. 2009, 393(4) pp 1267-1272. November 30, 2008. DOI: 10.1007/s00216-008-2533-7.
11.
An Adsorption Chromatography Assay to Probe Bulk Particle Transport Through Hydrogels. I. VLADESCU, O. LIELEG, S. JANG, KATHARINA
RIBBECK. Journal of Pharmaceutical Sciences. 2012, 101 (1) pp 4369-442. September 8, 2011. DOI 10.1002/jps.2273.
12.
BIOMOLECULAR STRATEGIES FOR CELL SURFACE ENGINEERING. John Tanner Wilson. 2008, December 5, 2008.
13.
Investigations into Improving the Separation of PEGylated Proteins. Vita Knudson, Tividar Farkas, and Michael McGinley. Phenomenex, (TN1034) www.Phenomenex.com/TechNotes/1034.
14.
Development of Polyethylene Glycol-Conjugated Alendronate, a Novel Nitrogen-Containing Bisphosphonate Derivative: Evaluation of
Absorption, Safety, and Effects After Intrapulmonary Administration in Rats. HIDEMASA KATSUMI, MIKI TAKASHIMA, JUN-ICHI SANO,
KAZUSHI NISHIYAMA, NORIKO KITAMURA, TOSHIYASU SAKANE, TORU HIBI, AKIRA YAMAMOTO. Journal of Pharmaceutical Sciences.
2011, 100 (9) pp 3783-3792. May 12, 2011. DOI: 10.1002/jps.22620.
15.
Stabilization of α-chymotrypsin upon PEGylation correlates with reduced structural dynamics. Jose´ A. Rodrı´guez-Martıńez, Ricardo J. Sola´,
Betzaida Castillo, Hećtor R. Cintroń-Colo´ n, Izarys Rivera-Rivera, Gabriel Barletta, Kai Griebenow. Biotechnology and Bioengineering. 2008,
101 (6) pp 1142-1149. December 15, 2008. DOI: 10.1002/bit.22014.
16.
Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis.
Atanas V. Koulov, Paul LaPointe, Bingwen Lu, Abbas Razvi, Judith Coppinger,_ Meng-Qiu Dong, Jeanne Matteson, Rob Laister, Cheryl
Arrowsmith, John R. Yates III, and William E. Balch. Molecular Biology of the Cell. 2010, 21 pp 871–884. March 15, 2010 DOI:
10.1091/mbc.E09–12–1017.
17.
Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. In Kap Ko, Assem
Ziady, Shiwei Lu, Young Jik Kwon. Biomaterials. 2008, 29 (28) pp 3872–3881. June 27, 2008. DOI:10.1016/j.biomaterials.2008.06.003.
18.
Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol.
Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Elsevier. 2010, 3 (146), pp 318-325. September 15, 2010.
DOI:10.1016/j.jconrel.2010.06.003.
19.
Molecular Dendritic Transporter Nanoparticle Vectors Provide Efficient Intracellular Delivery of Peptides, Sharon K. Hamilton and Eva Harth.
ACS Nano. 2009, 3 (2), pp 402–410. February 5, 2009. DOI: 10.1021/nn800679z.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
20.
Synthesis and Characterization of a New class of Cationic Protein Polymers for Multivalent Display and Biomaterial Applications, Nicolynn E.
Davis, Lindsay S. Karfield-Sulzer, Sheng Ding, and Annelise E. Barron. Biomacromolecules. 2009, 10 (5), pp 1125–1134. April 10, 2009. DOI:
10.1021/bm801348g.
21.
Noncovalent Cell Surface Engineering with Cationic Graft Copolymers, John T. Wilson, Venkata R. Krishnamurthy, Wanxing Cui, Zheng Qu,
and Elliot L. Chaikof. J. Am. Chem. Soc. 2009, 131 (51), pp 18228–18229. December 4, 2009. DOI: 10.1021/ja908887v.
22.
The impact of molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-Lysine Dendrimers, Lisa M.
Kaminskas, Ben J. Boyd, Peter Karellas, Guy Y. Krippner, Romina Lessene, Brian Kelly, and Christopher J. H. Porter. Mol. Pharmaceutics. 2008,
5 (3), pp 449–463. April 5, 2008. DOI: 10.1021/mp70012088.
23.
Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,Gary B Braun, Alessia Pallaoro, Guohui Wi, Dimitris Missirlis, Joseph A.
Zasadzinski, Matthew Tirrell, and Norbert O. Reich. ACS Nano. 2009, 3 (7), pp 2007–2015. June 15, 2009. DOI:10.1021/nn900469q.
24.
Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-L-lysine Dendrimers, Lisa M. Kaminskas, Brian D. Kelly,
Victoria M. McLeod, Ben J. Boyd, Guy Y. Krippner, Elizabeth D. Williams, and Christopher J. H. Porter, Mol. Pharmaceutics. 2009, 6 (4), pp
1190–1204. May 19, 2009. DOI: 10.1021/mp900049a.
25.
Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg,
Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS (J. Am. Chem. Soc.). 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI:
10.1021/ja809315x.
26.
Genetic PEGylation. Seiichi Tada, Takashi Andou, Takehiro Suzuki, Naoshi Dohmae, Eiry Kobatake, Yoshihiro Ito. PLoS One 2012 7 (11) pp
e49235 November 8, 2012. DOI:10.1371/journal.pone.0049235.
27.
Stimulation of F1-ATPase activity by sodium dodecyl sulfate, Muhammad Delawar Hossain, Shou Furuike, Yasuhiro Onoue, Keng Adachi,
Masasuke Yoshida, Kazuhiko Kinosita Jr. Biochimica et Biophysica Acta (BBA). Bioenergetics. 2010, 1797 (4), pp 435-442. April 2010.
DOI:10.1016/j.bbabio.2009.12.018.
28.
Multifunctional Separation Mechanism on Poly(oxyethylene) Stationary Phases in Capillary Liquid Chromatography. Toyohide Takeuchi and
Lee Wah Lim. Analytical Sciences. 2010, 26 (9) pp 937-941. September 10, 2010. DOI: 10.2116/analsci.26.937
29.
Capping Methotrexate R-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated
Polylysine Dendrimers. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Gian Sberna, Ben J. Boyd, David J. Owen, and Christopher J. H.
Porter. Mol. Pharmaceutics. 2011, 8 (2), pp 338–349. December 20, 2010. DOI: 10.1021/mp1001872.
30.
Torque Generation in F1-ATPase Devoid of the Entire Amino-Terminal Helix of the Rotor That Fills Half of the Stator Orifice. Ayako Kohori,
Ryohei Chiwata, Mohammad Delawar Hossain, Shou Furuike, Katsuyuki Shiroguchi, Kengo Adachi, Masasuke Yoshida, and Kazuhiko Kinosita,
Jr. Biophysical Journal. 2011, 101 (1), pp 188–195. July 6, 2011. DOI: 10.1016/j.bpj.2011.05.008.
31.
Stability, Antimicrobial Activity, and Cytotoxicity of Poly(amidoamine) Dendrimers on Titanium Substrates. Lin Wang, Uriel J. Erasquin,
Meirong Zhao, Li Ren, Martin Yi Zhang, Gary J. Cheng, Yingjun Wang, and Chengzhi Cai. ACS Applied Materials & Interfaces. 2011, 3 (8), pp
2885-2894, July 20, 2011. DOI: 10.1021/am2004398.
32.
Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation. José A. Rodríguez-Martínez, Izarys Rivera-Rivera and
Kai Griebenow. Journal of Pharmacy and Pharmacology. 2011, 63 (6), pp 800–805. January 6, 2011. DOI:10.1111/j.2042-7158.2011.01288.
33.
Development and Application of a Multimodal Contrast Agent for SPECT/CT Hybrid Imaging Jason M. Criscione, Lawrence W. Dobrucki,
Zhen W. Zhuang, Xenophon Papademetris, Michael Simons, Albert J. Sinusas and Tarek M. Fahmy. Bioconjugate Chem. 2011, 22 (9), pp
1784–1792. August 18, 2011. DOI: 10.1021/bc200162r.
34.
Temperature Dependence of the Rotation and Hydrolysis Activities of F1-ATPase. Furuike, Shou; Adachi, Kengo; Sakaki, Naoyoshi; ShimoKon, Rieko; Itoh, Hiroyasu; Muneyuki, Eiro; Yoshida, Masasuke; Kinosita, Kazuhiko, Jr. Biophysical Journal. 2008, 95 (2) pp 761-770 July 15,
2008. DOI:10.1529/biophysj.107.123307.
35.
Antibacterial Activities of Poly(amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups. Michelle K. Calabretta,
Amit Kumar, Alison M. McDermott, and Chengzhi Cai. Biomacromolecules. 2009, 5 (10), pp 1148-1156. May 28, 2009. DOI: 10.1039/b904746h.
36.
Potent D-peptide inhibitors of HIV-1 entry, Brett D. Welch, Andrew P. VanDemark, Annie Heroux, Christopher P. Hill, and Michael S. Kay.
PNAS. 2007, 43 (104), pp 16828-16833. October 23, 2007. DOI: 10.1073/pnas.0708109104.
37.
Characterization of Particle Translocation through Mucin Hydrogels. Oliver Lieleg, Ioana Vladescu, and Katharina Ribbeck. Biophysical
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NHS/TFP-dPEG®₄-( m-dPEG®x)₃-ester
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Amino-dPEG®x-acid
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Laccase- and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity. Navdeep Grover, Indrakant V. Borkar,
Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Enzyme and Microbial Technology. 2012, 50 (6-7) pp 271-279. January 24, 2012.
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Development of a sensitive surface Plasmon resonance immunosensor for detection of 2, 4-dinitrotoluene with a novel oligo (ethylene glycol)based sensor surface. Kazutaka Nagatomo, Toshikazu Kawaguchi, Norio Miura, Kiyoshi Toko, Kiyoshi Matsumoto. Talanta. 2009, 4 (79), p. 11421148. Sept. 15, 2009. DOI:10.1016/j.talanta.2009.02.018.
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Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen. Tiancheng
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Antistaphylococcal Nanocomposite Films Based on Enzyme- Nanotube Conjugates, Ravindra C. Pangule, Sarah J. Brooks, Cerasela Zoica
Dinu, Shyam Sundhar Bale, Sharon L. Salmon, Guangyu Zhu, Dennis W. Metzgeter, Ravi S. Kane, and Jonathan S. Dordick. ACS Nano. 2010, 4
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Influence of Different Spacers on the Biological Profile of a DOTA-Somatostatin Analogue. Patricia Antunes, Mihaela Ginj, Martin A. Walter,
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Amino-dPEG®₄-(m-dPEG®x)₃
1.
Design of cyclometalated iridium(III) polypyridine complexes as luminescent biological labels and probes. Kenneth Kam-Wing Lo, Kenneth Yin
Zhang, and Steve Po-Yam Li. Pure Appl. Chem. 2011, 83, (4) pp 823–840. February 28, 2011. doi:10.1351/PAC-CON-10-08-20.
2.
Modification of Luminescent IridiumACHTUNGTRENUNG(III) Polypyridine Complexes with discrete Poly(ethylene glycol) (PEG) Pendants:
Synthesis, Emissive behavior, Intracellular Uptake, and PEGylation Properties. Steve Po-Yam Li, Hua-Wei Liu, Kenneth Yin Zhang, and Kenneth
Kam-Wing Lo. Chemistry A European Journal. 2010, 16 (28), 8329 – 8339. July 26, 2010 DOI: 10.1002/chem 201000474.
Aminooxy-dPEG®x-amido-dPEG®x-(m-dPEG®x)x
1.
Simultaneous Dual Protein Labeling Using a Triorthogonal Reagent. Mohammad Rashidian, Sidath C. Kumarapperuma, Kari Gabrielse,
Adrian Fegan, Carston R. Wagner, and Mark D. Distefano. J. Am. Chem. Soc., 2013. October 17, 2013. DOI: 10.1021/ja403813b.
m-dPEG®x-MAL
1.
DksA2, a zinc-independent structural analog of the transcription factor DksA. Ran Furman, Tapan Biswas, Eric M. Danhart, Mark P. Foster,
Oleg V. Tsodikov, Irina Artsimovitch. FEBS Letters. 2013, 587 (6) pp 614–619. January 31, 2013. DOI: 10.1016/j.febslet.2013.01.073.
2.
Going through the barrier: coupled disulfide exchange reactions promote efficient catalysis in Quiescin sulfhydryl oxidase. Benjamin A. Israel,
Vamsi K. Kodali, and Colin Thorpe. The Journal of Biological Chemistry. 2013, December 30, 2013. DOI: 10.1074/jbc.M113.536219.
3.
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor. Clive Metcalfe, Peter Cresswell and A. Neil
Barclay. Open Biology. 2012, 2 (1). January 11, 2012. DOI: 10.1098/rsob.110036.
4.
Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide, Jolanta
Skalska, Paul S. Brookes, Sergiy M. Nadtochiy, Shannon P. Hilchey, Craig T. Jordan, Monica L. Guzman, Sanjay B. Maggirwar, Margaret M.
Briehl, Steven H. Bernstein. PLoS ONE. 4 (12), e8115. December 2, 2009. DOI: 10.1371 /journal.pone.0008115.
5.
Cell-Specific Delivery of Diverse Cargos by BacteriophageMS2 Virus-like Particles. Carlee E. Ashley Eric C. Carnes, Genevieve K. Phillips, Paul
N. Durfee, Mekensey D. Buley, Christopher A. Lino, David P. Padilla, Brandy Phillips, Mark B. Carter, Cheryl L. Willman, C. Jeffrey Brinker,
Jerri do Carmo Caldeira, Bryce Chackerian, Walker Wharton, and David S. Peabody.ACS Nano, 2011, 5 (7), pp 5729–5745, May 26, 2011. DOI:
10.1021/nn201397z.
6.
Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules. Nicholas M. Molino, Kateryna
Bilotkach, Deborah A. Fraser, Dongmei Ren, and Szu-Wen Wang. Biomacromolecules, 2012, 13 (4), pp 974–981. March 14, 2012.
10.1021/bm300083e.
MAL-dPEG®4-(m-dPEG®x)3
1.
Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Heather M.
Tyra, Douglas R. Spitz, and D. Thomas Rutkowski. Molecular Biology of the Cell. 2012, 23 (5) pp 811-819. March 1, 2012. DOI: 10.1091/mbc.E1112-1011.
2.
Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity. Anne Bravard, Monique Vacher, Eva
Moritz,Laurence Vaslin, Janet Hall,Bernd Epe,and J. Pablo Radicella. Cancer Research.2009, 69 (8) pp 3642-3649.April 7, 2009. 10.1158/00085472.CAN-08-3943.
3.
Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties. Furukawa Y, Kaneko
K, Nukina N. . The Journal of Biological Chemistry. 2011, 286 (31) pp 27236-46. June 9, 2011. 10.1074/jbc.M111.248963.
4.
Dissecting Molecular Interactions Involved in Recognition of Target Disulfides by the Barley Thioredoxin System. Olof Bjornberg, Kenji
Maeda, Birte Svensson, and Per Hagglund. Biochemistry. 2012, 51 (49) pp 9930-9939. November 19, 2012. DOI: 10.1021/bi301051b.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
5.
Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of
cadmium. Anne Bravard, Anna Campalans, Monique Vacher, Barbara Gouget, Céline Levalois, Sylvie Chevillard, J. Pablo Radicella. Mutation
Research. 2010, 685 (1-2) pp 61-69. October 2, 2009. DOI: 10.1016/j.mrfmmm.2009.09.013.
6.
Enzymatic Deglutathionylation to Generate Interleukin-4 Cysteine Muteins with Free Thiol. Viswanadham Duppatla, Maja Gjorgjevikj, Werner
Schmitz, Mathias Kottmair, Thomas D. Mueller, and Walter Sebald. Bioconjugate Chem., 2012, 23 (7), pp 1396–1405 June 9, 2012. DOI:
10.1021/bc2004389.
7.
Surface Location of Individual Residues of SlpA Provides Insight into the Lactobacillus brevis S-Layer. Heikki Vilen, Ulla Hynönen, Helga BadeltLichtblau, Nicola Ilk, Pentti Jääskeläinen, Mika Torkkeli and Airi Palva. J. Bacteriol. 2009, 191 (10) pp 3339-3351. March 20, 2009. DOI:
10.1128/JB.01782-08.
8.
The Chloroplast Twin Arginine Transport (Tat) Component, Tha4, Undergoes Conformational Changes Leading to Tat Protein Transport.
Cassie Aldridge, Amanda Storm, Kenneth Cline and Carole Dabney-Smith. J. Biol. Chem. 2012, 287 (1) pp 34752-34763. August 15, 2012. DOI:
10.1074/jbc.M112.385666.
Thiol-dPEG®x-acid
1.
Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and
Frederick R. Haselton. Langmuir, 2012, 28 (4), pp 2187–2193. December 9, 2011. DOI.org/10.1021/la203903a.
2.
Gold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity. Se Yeon Park, So Min Lee, Gae Baik,
Kim and Young-Pil Kim. Gold Bull. 2012, 45 pp 213–219. October 25, 2012. DOI 10.1007/s13404-012-0070-9.
3.
Enantioselective analysis of melagatran via a LSPR biosensor integrated with microfluidic chip. Longhua Guo, Yuechun Yin, Rong Huang, Bin
Qiu, Zhenyu Lin, HH Yang, Jianrong Li and Guo Nan Chen. Lab on a Chip. 2012, 20 (12), pp 3901-3906. June 15, 2012. DOI:
10.1039/C2LC40388A.
4.
Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting. Daniela Arosio, Leonardo Manzoni, Elena M. V. Araldi, and Carlo
Scolastico. Bioconjugate Chem. 2011, 22 (4), pp 664–672. March 24, 2011. DOI: 10.1021/bc100448r.
5.
Short-Chain PEG Mixed Monolayer Protected Gold Clusters Increase Clearance and Red Blood Cell Counts. Carrie A. Simpson, Amanda C.
Agrawal, Andrzej Balinski, Kellen M. Harkness, and David E. Cliffel. ACS Nano, 2011, 5 (5), pp 3577-3584. April 7, 2011. DOI:
10.1021/nn103148x.
m-dPEG®x-thiol
1.
Polymerase Chain Reaction-Free Variable-Number Tandem Repeat Typing Using Gold Nanoparticle–DNA Monoconjugates. Jong Young Choi
, Yong Tae Kim , and Tae Seok Seo. ACS Nano 2013, 7 (3) pp 2627–2633. February 12, 2013. DOI: 10.1021/nn400004d.
2.
Gold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity. Se Yeon Park, So Min Lee, Gae Baik,
Kim and Young-Pil Kim. Gold Bull. 2012, 45 pp 213–219. October 25, 2012. DOI 10.1007/s13404-012-0070-9.
3.
Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and
Frederick R. Haselton, Langmuir, 2012, 28 (4), pp 2187–2193 December 9, 2011. DOI.org/10.1021/la203903a.
Lipoamido-dPEG®x-acid
1.
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging. Wenhao Liu, Mark Howarth, Andrew B. Greytak, Yi Zheng, Daniel
G. Nocera, Alice Y. Ting, and Moungi G. Bawendi. J. Am. Chem. Soc. 2008, 130 (4) pp 1274–1284. January 5, 2008. DOI: 10.1021/ja076069p.
2.
Directed self-assembly of proteins into discrete radial patterns. Garima Thakur, Kovur Prashanthi and Thomas Thundat. Science Reports. 2013,
1923 (3) May 30, 2013. DOI: 10.1038/srep01923.
3.
PEGylated Luminescent Gold Nanoclusters: Synthesis, Characterization, Bioconjugation, and Application to Oneand Two-Photon Cellular
Imaging. Eunkeu Oh, Fredrik Fatemi, Marc Currie, James B. Delehanty, Thomas Pons, Alexandra Fragola, Sandrine Lévêque-Fort, Ramasis
Goswami, Kimihiro Susumu, Alan L. Huston, and Igor L. Medintz. Particle & Particle Systems Characterization 2013, (30), pp 1-13. February 5,
2013. DOI: 10.1002/ppsc.201200140.
4.
Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy. Mark F. McLaughlin, Jonathan Woodward,
Rose A. Boll, Jonathan S. Wall, Adam J. Rondinone, Stephen J. Kennel, Saed Mirzadeh, J. David Robertson. PLoS ONE 2012 8 (1)
e54531January 18, 2013. DOI:10.1371/journal.pone.0054531.
m-dPEG®x-Lipoamide
1.
Gastrointestinal Bioavailability of 2.0 nm Diameter Gold Nanoparticles. Candice A. Smith, Carrie A. Simpson, Ganghyeok Kim, Carly J. Carter,
and Daniel L. Feldheim. ACS Nano. 2013, 7 (5) pp 3991–3996. April 21, 2013. DOI: 10.1021/nn305930e.
2.
PEGylated Luminescent Gold Nanoclusters: Synthesis, Characterization, Bioconjugation, and Application to Oneand Two-Photon Cellular
Imaging. Eunkeu Oh, Fredrik Fatemi, Marc Currie, James B. Delehanty, Thomas Pons, Alexandra Fragola, Sandrine Lévêque-Fort, Ramasis
Goswami, Kimihiro Susumu, Alan L. Huston, and Igor L. Medintz. Particle & Particle Systems Characterization 2013, (30), pp 1-13. February 5,
2013. DOI: 10.1002/ppsc.201200140.
3.
Self-Assembled Quantum Dot-Sensitized Multivalent DNA Photonic Wires. Kelly Boeneman, Duane E. Prasuhn, Juan B. Blanco-Canosa, Philip
E. Dawson, Joseph S. Melinger, Mario Ancona, Michael H. Stewart, Kimihiro Susumu, Alan Huston, and Igor L. Medintz.
J. Am. Chem.
Soc., 2010, 132 (51), pp 18177–18190 December 8, 2010. DOI: 10.1021/ja106465x.
dPEG®x-SATA (S-acetyl-dPEG®x-NHS ester)
1.
Biodegradable Polydisulfide Dendrimer Nanoclusters as MRI Contrast Agents. Ching-Hui Huang, Kido Nwe, Ajlan Al Zaki, Martin W.
Brechbiel, and Andrew Tsourkas. ACS Nano. 2012, 6 (11) pp 9416–9424. October 25, 2012. DOI: 10.1021/nn304160p.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
2.
Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. Anna Bershteyn, Melissa C. Hanson, Monica
P. Crespo, James J. Moon, Adrienne V. Li, Heikyung Suh, Darrell J. Irvine. Journal of Controlled Release. 2011, 157 (3) pp 354-365. July 24,
2011. DOI: 10.1016/j.jconrel.2011.07.029.
3.
A new class of nontoxic nanoparticle tags based on surface enhanced Raman scattering. Qian, X.-M.; Ansari, D.; Nie, Shuming. Colloidal
Quantum Dots for Biomedical Applications II. 2007, Proceedings of the SPIE, Volume 6448, article id. 64480O. February 1, 2007.
10.1117/12.718459.
4.
Immobilization of His-tagged endoglucanase on gold via various Ni-NTA self-assembled monolayers and its hydrolytic activity. Nakamura
I, Makino A, Ohmae M, Kimura S. Macromolecular Bioscience. 2010, 10 (10) pp1265-1272. October 8, 2010. 10.1002/mabi.201000189.
5.
Synthesis and Function of Bioactive, Block Copolymer Surfactant Constructs as Relevant to the Preparation of Anticoagulant and Antibacterial
Medical Implant Surfaces. Pranav R. Joshi. Doctor of Philosophy in Chemical Engineering. 2006, November 17, 2006.
6.
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction. Shoji Akita, Naoki Umezawa, Nobuki
Kato, Tsunehiko Higuchi. Bioorganic & Medicinal Chemistry. 2008, 16 (16) pp 7788-94. July 1, 2008. 10.1016/j.bmc.2008.07.007.
7.
Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki,
Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.
8.
In vitro and in vivo evaluation of a non-carbohydrate targeting platform for lysosomal proteins, James E. Stefano, Lihui Hou, Denise Honey,
Josephine Kyazike, Anna Park, Qun Zhou, Clark Q. Pan, Tim Edmunds. Journal of Controlled Release. 2009, 2 (135), pp 113-118. April 17, 2009.
DOI: 10.1016/j.jconrel.2008.12.006.
Amino-dPEG®x-t-butyl ester
1.
High-purity discrete PEG-oligomer crystals allow structural insight. Alister C. French, Amber L. Thompson, and Benjamin G. Davis. Angew
Chem Int Ed Engl.2009, 48 (7) pp 1248-52. January 13, 2009 10.1002/anie.200804623.
2.
The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Sara D. Alvarez, Austin M.
Derfus, Michael P. Schwartz, Sangeeta N. Bhatia, Michael J. Sailor. Biomaterials. 2009, 30(1) pp26-34. September 4, 2008.
10.1016/j.biomaterials.2008.09.005.
3.
Chemical Modification of Silicon Surfaces for Biological Applications. Michael P. Schwartz, Frédérique Cunin, Ronnie W. Cheung, Michael J.
Sailor. physica status solidi. 2005, 202 (8) pp 1380-1384. May 23, 2005. 10.1002/pssa.200461106.
HO-dPEG®x-CO₂-t-butyl ester
1.
Synthesis of Poly(amidoamine) Dendron-Bearing Lipids with Poly(ethylene glycol) Grafts and Their Use for Stabilization of Nonviral Gene
Vectors. Toshinari Takahashi, Jun Hirose, Chie Kojima, Atsushi Harada, and Kenji Kono. Bioconjugate Chem. 2007, 18 (4) pp 1163–1169. June
15, 2007. DOI: 10.1021/bc070014v.
Amino-dPEG®x-alcohol
1.
Development of an oligo (ethylene glycol)-based SPR immunosensor for TNT detection, Yutaka Mizuta, Takeshi Onodera, Praveen Singh,
Kiyoshi Matsumoto, Norio Miura, Kiyoshi Toko. Biosensors and Bioelectronics. 2008, 24 (2), pp 191-197. Ocyober 15, 2008.
DOI:10.1016/j.bios.2008.03.042.
2.
Synthesis of Biotinylated r-D-Mannoside or N-Acetyl _-D-Glucosaminoside Decorated Gold Nanoparticles: Study of Their Biomolecular
Recognition with Con A and WGA Lectins. Xiaoze Jiang, Abdelghani Housni, Guillaume Gody, Paul Boullanger, Marie-The´re`se Charreyre,
Thierry Delair, and Ravin Narain. Bioconjugate Chem. 2010, 21 pp 521–530. February 3, 2010. DOI: 10.1021/bc900431p.
3.
Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical
Chemistry. 2010, 82 (18) pp 7766-7771 September 15, 2010. DOI: 10.1021/ac1016826.
4.
Quantum Dots with Multivalent and Compact Polymer Coatings for Efficient Fluorescence Resonance Energy Transfer and Self-Assembled
Biotagging. Hongwei Duan , Min Kuang and Y. Andrew Wang. Chemistry of Materials. 2010, 22 (15) pp 4372–4378. July 13, 2010.
10.1021/cm100442x.
5.
Surface Chemical Functionalization of Cylindrical Nanopores Derived from a Polystyrene−Poly(methylmethacrylate) Diblock Copolymer via
Amidation. Yongxin Li and Takashi Ito. Langmuir. 2008, 24 (16) pp 8959–8963. July 1, 2008. DOI: 10.1021/la800992f.
6.
Label-Free Detection of Proteins in Crude Cell Lysate with Antibody Arrays by a Surface Plasmon Resonance Imaging Technique, Motoki Kyo,
Kazue Usui-Aoki, and Hisashi Koga. Analytical Chemistry. 2005, 77 (22), pp 7115–7121. October 18, 2005. DOI: 10.1021/ac050884a.
7.
Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices. Grace M. Credo, Xing Su,
Kai Wu, Oguz H. Elibol, David J. Liua, Bobby Reddy Jr., Ta-Wei Tsai, Brian R. Dorvel, Jonathan S. Daniels, Rashid Bashir, and Madoo Varma.
Analyst. 2012 137 (6) p 1351-1362. March 21, 2012. DOI:10.1039/c2an15930a.
8.
Real-Time Video Imaging of Protease Expression In Vivo. Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma,
Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Chen.Theranostics. 2011, (1) pp. 18-27. January 12, 2011.
http://www.thno.org/v01p0018.htm.
S-acetyl-dPEG®x-alcohol
1.
5’-Sulfhydryl-Modified RNA: Initiator Synthesis, in Vitro Transcription, and Enzymatic Incorporation. Lei Zhang, Lele Sun, Zhiyong Cui, Robert L.
Gottlieb and Biliang Zhang. Bioconjugate Chem.2001, 12 (6) pp 939–948. October 16, 2001. DOI: 10.1021/bc015504g.
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42
dPEG® Based Crosslinking Reagents
Heterobifunctional Reagents: Amine and Thiol Reactive
dPEG ® Based Crosslinking Reagents
4-formyl-benzamido-dPEG ®xTFP ester
Convert an AMINE to a dPEG ® containing ALDEHYDE,
reactable with an aminooxy or hydrazide compound!


Aldehydes
(latent)
are
common
in
carbohydrates,
carbohydrate
containing
proteins, in oxidizable matrices, among others
AND can be incorporated using reagents like
the 4-FB-dPEG®x TFP esters (amine reactive)
Aminooxy-dPEG®s with a LABEL. Quanta has
available a BIOTIN label. PN 11112 below is
perfect for making your own
Product #
Description
100 mg
1000 mg
10081
4-formyl-benzamido-dPEG ®12-TFP ester
$200
$1250
$275
$1500
10082
4-formyl-benzamido-dPEG ®24-TFP ester
References:
Tel. 866 792-9222
Fax 614 760-9781
43
Phthalimidooxy-dPEG ®x
NHS ester
A New dPEG ® Reagent for Stable Oxime
Conjugation Systems!
Aldehydes (latent) are common in
carbohydrates, carbohydrate containing
proteins, in oxidizable matrices, including
most native antibodies and many enzymes,
for example, HRP. The amines from the
lysines in proteins can also be converted to
aldehydes and incorporated using reagents
like the 4-FB-dPEG®x TFP esters (amine
reactive). See PN’s 10081 and 10082.
Product #
Description
100 mg
1000 mg
10011
Phthalimidooxy-dPEG®4 NHS ester
$100
$750
$250
$1250
Phthalimidooxy-dPEG®12 NHS ester
11135
Tel. 866 792-9222
Fax 614 760-9781
44
MAL-dPEG®x-NHS ester
O
O
NH 2
+
NHS-dPEG ®x-MAL
MAL =
dPEG®X-MAL
N
H
O
O
O
O
dPEG®X-MAL
+
N
dPEG®X N
SH
S
O
Try it with you antigens on your carrier protein and be amazed!
O
O
O
Carrier
Protein,
e.g., KLH,
BSA, OVA
H2N
H2N
O
O
-NH2
O
-NH2
O
dPEG®x
HN
N
O
dPEG®x
dPEG®x
-NH2
O
O
-NH
-NH2
dPEG®x
O
O
-NH
N
-H
-NH
-NH2
2
-NH2
N
-H
-NH2
N
dPEG®xN
-NH
O
O
O
-NH
HN
O
10266
O
dPEG®x
O
O
Product #
O
Carrier
Protein,
e.g., KLH,
BSA, OVA
H2N
O
N
O
N
HN
N dPEG®x
-NH2
H2N
O
N dPEG®x
-NH2
-NH2
O
H2N
-NH
-NH2
O
-NH
2
-NH2
-NH2
dPEG®x
-NH
N
O
-NH
Make a new generation of antibodies with a superior
carrier...higher loading, more soluble, greater yields of a
better antibody! Could there be more? Find out for
yourself!
O
dPEG®x
N
O
O
N
O
O
dPEG®x
O
O
N
O
dPEG®x O
N
O
Description
100 mg
1000 mg
MAL-dPEG ®2-NHS ester
$150
$250
$200
$300
$215
$350
$225
$500
$225
$750
$250
$1250
10214
O
O
N
O
N
H
O
O
O
O
O
O
O
N
O
®
10064
O
O
O
N
H
N
O
O
O
O
O
O
O
O
O
N
O
®
10274
O
O
N
N
H
O
O
O
O
O
O
O
O
O
O
O
N
O
O
10284
10314
O
O
N
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
O
References:
276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718722.
Tel. 866 792-9222
Fax 614 760-9781
45
MAL-dPEG®x-acid
O
O
+
NH 2
NHS-dPEG ®x-MAL
MAL =
dP EG®X-MAL
N
H
O
O
O
O
dPEG®X-MAL
+
N
dPEG®X N
SH
S
O
Try it with your antigens on your carrier protein and be amazed!
O
O
O
O
O
-NH2
O
N dPEG®x
-NH2
H2N
O
-NH2
dPEG®x
O
N
O
O
dPEG®x
N
O
dPEG®x
-NH
Carrier
Protein,
e.g., KLH,
BSA, OVA
H2N
HN
-NH
O
O
O
-NH
-NH2
dPEG®x
N
-H
N
-NH
2
-NH2
N
-H
-NH2
-NH2
O
dPEG®x
N
O
O
dPEG® x O
N
O
dPEG® x
-NH2
HN
O
dPEG®xN
O
-NH
O
O
O
O
HN
O
N
-NH2
O
N dPEG®x
-NH2
Carrier
Protein,
e.g., KLH,
BSA, OVA
H2N
O
-NH
-NH2
H2N
H2N
O
-NH
2
-NH2
-NH2
dPEG®x
-NH
N
O
-NH
Make a new generation of antibodies with a superior
carrier...higher loading, more soluble, greater yields of a
better antibody! Could there be more? Find out for
yourself!
O
O
N
O
dPEG®x
O
N
O
O
roduct #
Description
100 mg
1000 mg
10265
MAL-dPEG ®2-acid
$60
$100
$100
$125
$125
$150
$225
$275
$225
$300
$225
$1250
MAL-dPEG ®4-acid
10338
MAL-dPEG ®6-acid
10065
O
O
N
O
N
H
O
O
O
O
O
O
O
OH
10275
MAL-dPEG ®8-acid
10285
MAL-dPEG ®12-acid
10315
MAL-dPEG ®24-acid
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0)., See
pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SMCC or sulfo-SMCC on pp. 283-286.
Tel. 866 792-9222
Fax 614 760-9781
46
MAL-dPEG ®x-t-boc-hydrazide
Product #
Description
10210
MAL-dPEG ®4-t-boc-hydrazide
O
O
O
N
H
N
O
O
O
O
N
H
H
N
O
100 mg
1000 mg
$175
$900
$200
$1000
$225
$1100
O
O
10961
10962
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See pp.
297-302 for general description and use of the conventional linkers like our dPEG® version
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47
SPDP-dPEG ®x-NHS ester
NH2
+
S
N
H
dPEG® x--NHS
dPEG ®
X
S
dPEG ®X
S
S
N
+
N
H
SH
Reduce: TCEP, DTT, TE
O
N
H
N
dPEG ®X
S-S
O
O
dPEG® X
S
O
O
O
O
N
H
S
O
O
O
N
SH
+
N dPEG ®X
; or other thiol reactive
partners
O
= Enzyme, protein; 5'-amineoligo; antibody
Product #
Description
100 mg
1000 mg
10374
SPDP-dPEG®4-NHS ester
$225
$1075
$250
$1200
$250
$1200
$275
$1325
$300
$1450
10376
10378
SPDP-dPEG®24 -NHS ester
10379
10867
References:
Tel. 866 792-9222
Fax 614 760-9781
48
SPDP-dPEG ®x-acid
NH2
+
S
N
H
dPEG® x--NHS
dPEG ®
O
X
S
S
N
+
N
H
SH
Reduce: TCEP, DTT, TE
O
N
H
S
N
O
dPEG ®X
S-S
O
O
dPEG® X
S
dPEG ®X
O
O
N
H
S
O
O
O
N
SH
+
N dPEG ®X
; or other thiol reactive
partners
O
= Enzyme, protein; 5'-amineoligo; antibody
Product #
Description
100 mg
1000 mg
10373
SPDP-dPEG®4-acid
$225
$400
$250
$600
$250
$800
$275
$1100
$300
$1450
SPDP-dPEG®8-acid
10375
SPDP-dPEG®12-acid
10377
SPDP-dPEG®24-acid
10380
SPDP-dPEG®36-acid
10866
Mol. Wt.: 1872.26; single compound; dPEG® Spacers are 137.8 atoms and 115 Å
References:
Tel. 866 792-9222
Fax 614 760-9781
49
Tris(2-carboxyethyl)phosphine
hydrochloride (TCEP)
Product #
Description
1000 mg
5000 mg
10014
Tris(2-carboxyethyl)phosphine hydrochloride (TCEP))
$55
$100
O
HO
O
P
OH
HCl
O
OH
Mol. Wt.: 286.65; single compound
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pages 9597 (protocol), 654
Tel. 866 792-9222
Fax 614 760-9781
50
Homobifunctional Reagents: Amine Reactivee
Homobifunctional Reagents: Amine Reactive
Bis-dPEG®x-NHS ester
O
NHS
E.g., Activate amine surface with NHS
H2N
NH2
O
+
H 2N
O
dPEG®
NHS
O
HN
O
dPEG ®x
xO
O
O
O
HN
O
NH
NH
O
dPEG®x
O
®
dPEG x
NHS
NHS
dPEG ®x
NH
O HN
O
H 2N
NH
O HN
dPEG® xO
dPEG ®x
NHS
NH2
HN
NHS
NH
= Small molecule; modified surface; peptide, oligo
O
= Small molecule; modified surface; peptide, oligo
dPEG®x
O
dPEG ®x
HN
NH
Product #
Description
100 mg
1000 mg
10724
Bis-dPEG ®2-NHS ester
$150
$335
$150
$335
$150
$385
$150
$435
$225
$525
10726
10699
O
N
O
O
O
O
O
O
O
O
O
O
N
O
®
10224
10988
O
N
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
Tel. 866 792-9222
Fax 614 760-9781
51
Bis-dPEG ®x-NHS ester (cont.)
Product #
Description
10246
O
N
O
O
O
O
O
O
O
O
O
O
O
O
O
100 mg
1000 mg
$250
$550
$275
$900
$300
$1275
$325
$1350
$350
$1400
O
O
N
O
10954
10979
O
N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
10956
10968
O
N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
O
Tel. 866 792-9222
Fax 614 760-9781
52
Bis-dPEG ®x-PFP & TFP esters
NEW! All of our bis-dPEG® x NHS esters, now as the PFP esters!
More aqueous stable than the NHS esters!
Product #
Description
100 mg
1000 mg
10981
Bis-dPEG ®2-PFP ester
$150
$650
$150
$550
$150
$650
$150
$650
$225
$750
F
F
F
F
F
O
O
O
O
O
O
F
F
F
F
F
®
10982
F
F
F
F
F
F
O
O
O
O
O
O
F
O
F
F
F
10085
Bis-dPEG ®4-TFP ester
10015
10987
Tel. 866 792-9222
Fax 614 760-9781
53
Bis-dPEG ®x-PFP & TFP ester (cont.)
Product #
Description
100 mg
1000 mg
10983
$250
$1100
$275
$1200
$300
$1275
$325
$1350
$350
$1400
10984
10980
10985
Bis-dPEG ®25-TFP ester
10092
Tel. 866 792-9222
Fax 614 760-9781
54
Bis-dPEG®x-acid
Product #
Description
100 mg
1000 mg
10723
Bis-dPEG ®2-acid
$125
$550
$125
$550
$125
$550
$125
$550
$200
$800
$225
$1000
$250
$1100
$275
$1200
O
HO
O
O
OH
O
Bis-dPEG ®3-acid
10725
O
O
HO
O
O
O
OH
Bis-dPEG ®4-acid
10698
O
HO
O
O
O
O
OH
O
Bis-dPEG ®5-acid
10230
Bis-dPEG ®7-acid
10236
Bis-dPEG ®9-acid
10245
Bis-dPEG ®13-acid
10953
Bis-dPEG ®17-acid
10978
O
HO
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Bis-dPEG ®21-acid
10955
$300
$1275
$325
$1350
Bis-dPEG ®25-acid
10967
O
HO
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
®
Bis-dPEG ®29-acid
10320
$375
$1500
Tel. 866 792-9222
Fax 614 760-9781
55
Click Reagents: Azide
Azido-dPEG ®x-NHS ester
Product #
Description
100 mg
1000 mg
10501
Azido-dPEG®4-NHS ester
$175
$900
$200
$1050
$225
$1125
10503
10505
Tel. 866 792-9222
Fax 614 760-9781
56
Azido-dPEG®x-acid
Product #
Description
100 mg
1000 mg
10502
Azido-dPEG®4-acid
$200
$850
$225
$1100
$250
$1150
$275
$1200
Azido-dPEG®8-acid
10512
O
N3
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 467.51; single compound; dPEG Spacer is 28 atoms and 32.2 Angstroms
®
Azido-dPEG®12-acid
10513
O
N3
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 643.72 ; single compound; dPEG® Spacer is 40 atoms and 46.4 Angstroms
Azido-dPEG®24-acid
10514
N3
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 1172.35; single compound; dPEG® Spacer is 76 atoms and 90.44 Angstroms
Tel. 866 792-9222
Fax 614 760-9781
57
Azido-dPEG ®x-amine
O
NHS
+
(reduction)
NH-dPEG ®x-N3
NH2-dPEG ®x-N 3
=
O
NH-dPEG ®x-NH2
Carboxyl reactive …also acts as a mono-protected diamine (reduce azide to amine)
Product #
Description
10522
Azido-dPEG®3-amine
H2N
O
O
O
100 mg
1000 mg
$100
$400
$200
$500
$250
$600
$300
$1250
$350
$1350
N3
Azido-dPEG®7-amine
10523
Azido-dPEG®11-amine
10524
10525
10526
Mol. Wt.: 1627.94; single compound; dPEG® Spacers are 107 atoms and 129 Å
Tel. 866 792-9222
Fax 614 760-9781
58
Click Reagents: Amine and Carboxyl Acetylide Partners
Click Reagents: Amine and Carboxyl Acetylide Partners
Propargyl-dPEG ®1-NHS ester
Product #
Description
100 mg
1000 mg
10511
Propargyl-dPEG®1-NHS ester
$100
$450
Propargyl amine
Product #
Description
1000 mg
10510
Propargyl amine
$50
Mol. Wt.: 55.08; single compound; Spacer is 4 atoms and 3.5 Å
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Pp. 722716 (Greg has several general protocols on pp. 725 and 726).
Tel. 866 792-9222
Fax 614 760-9781
59
Homobifunctional: Thiol Reactive
Homobifunctional: Thiol Reactive
Bis-MAL-dPEG ®x
Product #
Description
10215
Bis-MAL-dPEG ®3
50 mg
1000 mg
$125
$750
$225
$1200
O
O
H
N
N
O
O
H
N
O
O
N
O
O
O
Bis-MAL-dPEG ®11
10397
Homobifunctional: Diamine Monoprotected
t-boc-N-amido-dPEG®x-amine
O
O
NHS
+
NH2-dPEG® x-NH
O
NH-dPEG ®x-NH
O
=
O
(Acid)
O
NH-dPEG ®x-NH2
Product #
Description
10225
t-boc-N-amido-dPEG®3-amine
100 mg
1000 mg
NA
$200
$235
$1050
O
H2N
O
O
O
N
H
O
®
t-boc-N-amido-dPEG®11-amine
10172
Tel. 866 792-9222
Fax 614 760-9781
60
Azido-dPEG ®x-amine
O
NHS
+
(reduction)
NH-dPEG ®x-N3
NH2-dPEG ®x-N 3
=
O
NH-dPEG ®x-NH2
Carboxyl reactive …also acts as a mono-protected diamine (reduce azide to amine)
Product #
Description
10522
Azido-dPEG®3-amine
H2 N
O
O
O
100 mg
1000 mg
$100
$800
$200
$1000
$250
$1150
$300
$1250
$350
$1350
N3
Azido-dPEG®7-amine
10523
10524
10525
10526
Mol. Wt.: 1627.94; single compound; dPEG® Spacers are 107 atoms and 129 Å
Diamido-dPEG ®11-diamine
* Licensed under U.S. Pat. No. 6,492,560 B2
Product #
Description
100 mg
1000 mg
10361
Diamido-dPEG ®11-diamine
$150
$800
Tel. 866 792-9222
Fax 614 760-9781
61
CBZ-N-amido-dPEG ®3-amine
Product #
Description
1000 mg
10269
CBZ-N-amido-dPEG ®3-amine
$375
t-boc-N-EDA
Product #
Description
1000 mg
10226
t-boc-N-EDA
$175
Tel. 866 792-9222
Fax 614 760-9781
62
Miscellaneous: Homobifunctional; Monoprotected
Acid-dPEG®x-NHS ester
Product #
Description
100 mg
1000 mg
10109
Acid-dPEG ®5-NHS ester
$215
$1200
$230
$1250
$250
$1300
$300
$1450
10119
10127
10140
Tel. 866 792-9222
Fax 614 760-9781
63
Amino-dPEG ®11-ONH-t-boc


Aldehydes (latent) are common in carbohydrates, carbohydrate containing proteins, in oxidizable matrices,
among others AND can be incorporated using reagents like the 4-FB-dPEG®x TFP esters (amine reactive)
Aminooxy-dPEG ®s with a LABEL. Quanta has available a BIOTIN label. PN 11112 below is perfect for making
your own
Product #
Description
100 mg
1000 mg
11112
Amino-dPEG®11-ONH-t-boc
$250
$1200
References:
Bis-dPEG ®5, half benzyl half NHS ester
Product #
Description
100 mg
1000 mg
10237
Bis-dPEG ®5, half benzyl half NHS ester
$250
$1100
Tel. 866 792-9222
Fax 614 760-9781
64
Thiol Reactive Miscellaneous without dPEG ®
Thiol Reactive Miscellaneous
MPS (NHS-3-maleimidopropionate)
Description
250 mg
1000 mg
MPS (NHS-3-maleimidopropionate)
$200
$400
Product #
10217
MPS-Acid
Product #
Description
100 mg
1000 mg
10323
MPS-Acid
$100
$350
MPS-EDA.TFA
Product #
Description
100 mg
1000 mg
10177
MPS-EDA.TFA
$225
$750
O
O
N
N
H
NH3+CF3COO-
O
Mol. Wt. 325.24; single compound; dPEG® Spacer is 10 atoms and 10.7 Å
Tel. 866 792-9222
Fax 614 760-9781
65
Bis-Maleimide amine, TFA salt
Product #
Description
100 mg
1000 mg
10232
Bis-Maleimide amine, TFA salt
$225
$750
Mol. Wt.: 660.64; single compound; Spacers are 17 and 21 atoms and 19.1 and 19.6 Å, resp.
Tel. 866 792-9222
Fax 614 760-9781
66
Bis-MAL-Lysine-dPEG ®4-acid
Product #
Description
100 mg
1000 mg
10630
Bis-MAL-Lysine-dPEG®4-acid
$225
$1050
Tel. 866 792-9222
Fax 614 760-9781
67
Bis-MAL-Lysine-dPEG ®4-TFP ester
Product #
Description
100 mg
1000 mg
10631
Bis-MAL-Lysine-dPEG®4-TFP ester
$250
$1250
Tel. 866 792-9222
Fax 614 760-9781
68
Others
Others
Amino-dPEG ®x-t-boc-hydrazide
Product #
Description
10041
Amino-dPEG®4-t-boc-hydrazide
O
H2N
O
O
O
O
N
H
H
N
100 mg
1000 mg
$150
$750
$250
$950
$300
$1050
O
O
10957
10958
Tel. 866 792-9222
Fax 614 760-9781
69
Others
Fmoc-N-amido-dPEG ®4-t-boc-hydrazide
Product #
Description
100 mg
1000 mg
10043
Fmoc-N-amido-dPEG®4-t-boc-hydrazide
$175
$750
NHS-dPEG ®4-t-boc-hydrazide
Product #
Description
100 mg
1000 mg
10044
NHS-dPEG®4-t-boc-hydrazide
$200
$1000
Tel. 866 792-9222
Fax 614 760-9781
70
References
4-formyl benzamido-dPEG®x-TFP ester
1.
2.
Strategies for Neoglycan Conjugation to Human Acid r-Glucosidase. Qun Zhou, James E. Stefano, John Harrahy, Patrick Finn, Luis Avila, Josephine
Kyazike, Ronnie Wei, Scott M. Van Patten, Russell Gotschall, Xiaoyang Zheng, Yunxiang Zhu, Tim Edmunds, and Clark Q. Pan. Bioconjugate Chem. 2011,
22 pp 741–751. March 18, 2011. doi.org/10.1021/bc1005416.
Single-Step Conjugation of Antibodies to Quantum Dots for Labeling Cell Surface Receptors in Mammalian Cells. Gopal Iyer, Jianmin Xu, and Shimon
Weiss. Bioconjugation Protocols. 2011, 751 pp 553-563. January 2, 2011. DOI: 10.1007/978-1-61779-151-2_34.
MAL-dPEG®x-NHS ester
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
111In-Labeled Immunoconjugates (ICs) Bispecific for the Epidermal Growth Factor Receptor (EGFR) and Cyclin-Dependent Kinase Inhibitor, p27Kip1.
Bart Cornelissen, Veerle Kersemans, Kristin McLarty, Lara Tran, Raymond M. Reilly. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 2009, 24 (2)
pp 163-173. May 1, 2009. DOI: 10.1089/cbr.2008.0553.
Therapy of Murine Pulmonary Aspergillosis with Antibody-Alliinase Conjugates and Alliin. Elena Appel, Alexandra Vallon-Eberhard, Aharon Rabinkov, Ori
Brenner, Irina Shin, Keren Sasson, Yona Shadkchan, Nir Osherov, Steffen Jung, and David Mirelman. AAC. 2010. 54 (2) pp 898–906. February 1,2010.
doi:10.1128/AAC.01267-09.
Conjugation of Peptides to the Passivation Shell of Gold Nanoparticles for Targeting of Cell-Surface Receptors. Lisa Maus, Oliver Dick, Hilmar Bading,
Joachim P. Spatz, and Roberto Fiammengo. ACS Nano. 2010, 4 (11), pp 6617–6628. October 7, 2010. DOI: 10.1021/nn101867w.
Cell recruitment and transfection in gene activated collagen matrix. Silvia Orsi, Antonia De Capua, Daniela Guarnieri, Daniela Marasco, Paolo A. Netti.
Biomaterials. 2010, 31 (3) pp 570–576.October 7, 2009. DOI:10.1016/j.biomaterials.2009.09.054.
Development of a novel bead-based96-well filtrationplate competitive immunoassay for the detection of Gentamycin. Tien Yu Jessica Ho, ChiaChungChan, KingHoChan, YuChiehWang, Jing-TangLin, Cheng-Ming Chang, Chien-ShengChen. Biosensors and Bioelectronics. 2013, 49 pp
126–132.May 8,2013. DOI: 10.1016/j.bios.2013.04.027.
Fluorescent homogeneous immunosensors for detecting pathogenic bacteria. Ewa Heyduk, Tomasz Heyduk. Analytical Biochemistry. 2010, 396 (2) pp
298–303. September 24, 2009. DOI:10.1016/j.ab.2009.09.039.
Structural characterization and functionalization of engineered spider silk films. Kristina Spieß, Stefanie Wohlrab and Thomas Scheibel. Soft Matter. 2010,
6 (17) pp 4168-4174. June 16, 2010. DOI: 10.1039/b927267d.
Single molecule tracking of quantum dot-labeled mRNAs in a cell nucleus. Yo Ishihama, Takashi Funatsu. Biochemical and Biophysical Research
Communications. 2009, 381 pp 33-38. February 8, 2009. DOI:10.1016/j.bbrc.2009.02.001.
Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities. Geoffrey von Maltzahn, Dal-Hee Min, Yingxin Zhang, Ji-Ho Park,
Todd J. Harris, Michael Sailor, Sangeeta N. Bhatia. Advance Materials. 2007, 19 (21) pp 3579-3583. October 16, 2007. DOI: 10.1002/adma.200701183.
MicroSPECT/CT imaging of co-expressed HER2 and EGFR on subcutaneous human tumor xenografts in athymic mice using 111In-labeled bispecific
radioimmunoconjugates. Eva Razumienko, Lindsay Dryden, Deborah Scollard, Raymond M. Reilly. Breast Cancer Res Treat. 2013, 138 (3) pp 709-718.
March 24, 2013. DOI: 10.1007/s10549-013-2490-5.
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard
Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry 15, 2007,20 (15), pp 6565 – 6573
July 25, 2007. DOI:10.1016/j.bmc.2007.07.001.
Efficient capture of circulating tumor cells with a novel immunocytochemical microfluidic device. Mary Nora Dickson, Pavel Tsinberg, Zhongliang Tang,
Farideh Z. Bischoff, Timothy Wilson, and Edward F. Leonard. Biomicrofluidics. 2011, 5 (3). August 22, 2011. DOI:10.1063/1.3623748.
Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging. Young-Seok Cho, Tae-Jong Yoon, EueSoon Jang, Kwan Soo Hong, Shin Young Lee, Ok Ran Kim, Cheongsoo Park, Yong-Jin Kim, Gyu-Chul Yi, Kiyuk Chang. Cancer Letters. 2010, 299 (1) pp 6371. August 9, 2010. DOI: 10.1016/j.canlet.2010.08.004.
Immobilizing Reporters for Molecular Imaging of the Extracellular Microenvironment in Living Animals. Zuyong Xia, Yun Xing, Jongho Jeon, Young-Pil
Kim, Jessica Gall, Anca Dragulescu-Andrasi, Sanjiv S. Gambhir, and Jianghong Rao. ACS Chem. Biol. 2011, 6 (10), pp 1117–1126. August 10, 2011. DOI:
10.1021/cb200135e.
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Eric A. Murphy, Bharat K. Majeti, Leo A. Barnes, Milan Makale, Sara
M. Weis, Kimberly Lutu-Fuga, Wolfgang Wrasidlo, David A. Cheresh. PNAS. 2008, 105 (27) pp 9343-9348. July 8, 2008. DOI: 10.1073/pnas.0803728105.
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Rafal Goraczniak, Brian A Wall, Mark
A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng
Jenny Yu, Stephanie LaCava, Kenneth R Reuhl,Suzie Chen, and Samuel I Gunderson. Citation: Molecular Therapy–Nucleic Acids. 2013, 2 (e92). May 14,
2013. DOI: 10.1038/mtna.2013.24.
Self-Protecting Bactericidal Titanium Alloy Surface Formed by Covalent Bonding of Daptomycin Bisphosphonates. Chang-Po Chen and Eric Wickstrom.
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Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Nathan J Alves, Tanyel
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Novel Nanoassemblies Composed of Squalenoyl—Paclitaxel Derivatives: Synthesis, Characterization, and Biological Evaluation, Franco Dosio, L.
Harivardhan Reddy, Annalisa Ferrero, Barbara Stella, Luigi Cattel, and Patrick Couvreur. Bioconjugate Chem. 2010, 21 (7), pp 1349–1361. July 2, 2010. DOI:
10.1021/bc100154g.
Diamido-dPEG®x-diamine
1.
Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on y-Secretase. Sophia Schedin-Weiss,
Mitsuhiro Inoue, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Helena Karlstrom, Bengt Winblad, Lars O. Tjernberg. PLoS ONE 2013, 8 (5) e63962. May
24, 2013. DOI:10.1371/journal.pone.0063962.
t-boc-N-EDA
1.
DEVD-NucView 488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells. Hui Cen, Fei Mao, Ida Aronchik,
Rholinelle Joy Fuentes, and Gary L. Firestone. The FASEB Journal. 2008, (22), pp 2243-2252. July 2010. DOI: 10.1096/fj.07-099234.
MPS(NHS-3-maleimidopropionate)
1.
2.
Biodistribution of 211At labeled HER-2 binding affibody molecules in mice. Ann-Charlotts teffen, Ylva Almqvist, Ming-Kuan Chyan, Hans Lundqvist,
Vladimir Tolmachev, D. Scott Wilbur and Jorgen Carlsson. Oncology Reports. 2007, 17 (5) pp 1141-1147. May 1, 2007. DOI: www.tessera.spandidospublications.com/or/17/5/1141.
Reagents for Astatination of Biomolecules. 2. Conjugation of Anionic Boron Cage Pendant Groups to a Protein Provides a Method for Direct Labeling
that is Stable to in Vivo Deastatination. D. Scott Wilbur, Ming-Kuan Chyan, Donald K. Hamlin, Robert L. Vessella, Timothy J. Wedge, and M. Frederick
Hawthorne. Bioconjugate Chem. 2007, 18 (4) pp 1226–1240. June 21, 2007. DOI: 10.1021/bc060345s.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
Bis-Maleimide amine, TFA Salt
1.
2.
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators. Justin M. Scheer, Wendy Sandoval, J. Michael Elliott, Lily Shao,
Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen. PLOS ONE. 2012, 7 (12) e51817. December 20, 2012. DOI:
10.1371/journal.pone.0051817.
Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung Kim, Hai
Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee. Bioconjugate Chem. 2011, 22 (4), pp
625–632. March 14, 2011. DOI: 10.1021/bc100404x.
Bis-MAL-Lysine-dPEG®x-TFP ester
1.
Mono-PEGylated Dimeric Exendin-4 as High Receptor Binding and Long-Acting Conjugates for Type 2 Anti-Diabetes Therapeutics.Tae Hyung Kim, Hai
Hua Jiang, Seulki Lee, Yu Seok Youn, Chan Woong Park,Youngro Byun, Xiaoyuan Chen, and Kang Choon Lee, Bioconjugate Chem., 2011, 22 (4), pp
625–632 March 14, 2011. DOI: 10.1021/bc100404x.
Tel. 866 792-9222
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dPEG® Biotinylation Reagents
Amine Reactive
Amine Reactive
NHS-dPEG ®x-biotin
Extremely useful for labeling proteins especially on the available random lysines!
Due to the extreme solubility of the dPEG ® linker, up to 35-40 biotins can
be labeled on to an IgG with NO aggregation!
Product #
Description
50 mg
1000 mg
10200
NHS-dPEG®4-biotin
$100
$750
$150
$1250
$250
$1400
NHS-dPEG®12-biotin
10198
NHS-dPEG®24-biotin
10774
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically
see pp. 726-730 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Tel. 866 792-9222
Fax 614 760-9781
71
Amine Reactive
dPEG®x-biotin acid
Extremely useful for labeling proteins especially on the available random lysines!
Due to the extreme solubility of the dPEG ® linker, up to 35-40 biotins
can be labeled on to an IgG with NO aggregation!
Product #
Description
100 mg
1000 mg
10199
dPEG®4-biotin acid
$100
$600
$150
$975
$225
$1350
$300
$1500
dPEG®12-biotin acid
10197
10773
10776
Tel. 866 792-9222
Fax 614 760-9781
72
Amine Reactive
Biotin-dPEG ®x-TFP ester
Extremely useful for labeling proteins especially on the
available random lysines! Due to the extreme solubility of the
dPEG ® linker, up to 35-40 biotins can be labeled on to an
IgG with NO aggregation!
Product #
Description
100 mg
1000 mg
10009
Biotin-dPEG ®4-TFP ester
$100
$600
$150
$975
$250
$1400
10008
10007
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically
see pp. 726-729 in his Chapter 18 on discrete PEG compounds.
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Fax 614 760-9781
73
Amine Reactive
NHS-S-S-dPEG®4-biotin
Cleavable Biotinylation! See NHS-dPEG ®x biotin! This product can
label, but can subsequently be cleaved
with a reducing agent!
Product #
Description
50 mg
500 mg
10194
NHS-S-S-dPEG®4-biotin
$175
$875
$150
$1125
TFP-dPEG®4-Lys-(dPEG®4-biotin)2
10409
Mol. Wt.: 1488.72; single compound; dPEG® Spacers are 40 and 35 atoms and 43.4 and 41.7 Å, resp, Avg..
References:
Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Tel. 866 792-9222
Fax 614 760-9781
74
Amine Reactive
TFP/NHS-dPEG ®x-biotinidase
resistant biotin
Biotinidase resistant: Biotinidase is ubiquitous in serum and any
biotin amide bond will BE CLEAVED! This chemistry creates
a stable linkage in the presence of BIOTINIDASE!
Product #
Description
100 mg
1000 mg
10202
NHS-dPEG®4 -biotinidase resistant biotin
$150
$1200
$150
$1200
$250
$1750
10203
TFP-dPEG®4-biotinidase resistant biotin
10204
TFP-dPEG®12-biotinidase resistant biotin
Mol. Wt.: 1077.19; single compound; dPEG® Spacers are 43 atoms and 50.1 Å, resp.
Tel. 866 792-9222
Fax 614 760-9781
75
Carbonyl Reactive
Carbonyl Reactive
Biotin-dPEG ®4-hydrazide
Carbonyl reactive dPEG ® biotin reagent! Reacts with carboxylic
acids and aldehydes!
Product #
Description
50 mg
1000 mg
10219
Biotin-dPEG ®4-hydrazide
$250
$1100
References:
733-736 for a general discussion of the chemistry and a general protocol for labeling of a glycoprotein is given on pg. 736!
Tel. 866 792-9222
Fax 614 760-9781
76
Carbonyl Reactive
Biotin-dPEG®x-NH2
Product #
Description
100 mg
1000 mg
10193
Biotin-dPEG ®3-NH3+TFA -
$100
$750
$250
$900
$275
$1000
$300
$1100
Biotin-dPEG ®7-NH2
10826
Biotin-dPEG ®11-NH2
10196
Biotin-dPEG ®23-NH2
10786
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See pages
529 and 530 for a general discussion in Greg’s book and on biotinylation as well, as well as pp. 737 and 738 for a protocol for a compound with just two oxygen.
However, other than enhanced solubility and binding distances, the protocol is adaptable to our PN 10193.
Tel. 866 792-9222
Fax 614 760-9781
77
Carbonyl Reactive
Biotin-dPEG ®x-oxyamine. HCl


among others AND can be incorporated using reagents like the 4-FB-dPEG®x TFP esters (amine reactive)
Aminooxy-dPEG ®s with a LABEL. Quanta has available a BIOTIN label. PN 11102 below is perfect for making
your own
Product #
Description
50 mg
1000 mg
11100
Biotin-dPEG ®3-oxyamine. HCl
$100
$750
$150
$1250
Biotin-dPEG ®11-oxyamine. HCl
11102
References:
Tel. 866 792-9222
Fax 614 760-9781
78
Carbonyl Reactive
Biotin-dPEG ®4-SS-NH-dPEG ®3-ONH2
Product #
Description
50 mg
1000 mg
11106
Biotin-dPEG ®4-SS-NH-dPEG ®₃-ONH₂
$225
$1750
References:
Tel. 866 792-9222
Fax 614 760-9781
79
Thiol Reactive
Thiol Reactive
Biotin-dPEG ®x-MAL
Maleimide reacts VERY efficiently and rapidly with a thiol/sulfhydryl under
very mild conditions, pH 5 to 7.
®
...and the dPEG x biotin gives the same solubility and availabilty of the biotin
as amine and carbonyl reactive dPEG ® biotin reagents!
Product #
Description
25 mg
50 mg
100 mg
10201
Biotin-dPEG ®3-MAL
NA
$175
NA
$225
NA
$450
$250
NA
$500
O
NH
O
O
HN
N
H
S
O
O
O
O
N
H
N
O
Biotin-dPEG ®11-MAL
10195
O
HN
O
NH
N
H
S
O
O
O
O
O
O
O
O
O
O
O
O
N
H
O
N
O
Biotin-dPEG ®23-MAL
10785
O
HN
NH
S
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
H
N
O
O
References:
732-733 in Greg’s new edition for a summary of the reactions, plus a typical protocol.
Tel. 866 792-9222
Fax 614 760-9781
80
Photoaffinity Biotinylation Reagents
Photoaffinity Biotinylation Reagents
Biotin-dPEG ®3-benzophenone
dPEG ® Based Photoaffinity label: Inserts into some C-H bonds
using wavelengths that are Protein friendly!
R
O
R
H
+
H
N
O
NH
OH
R
H
N
R
O
O
HN
O
O
O
O
Light, UV, 360 nm
S
H
N
O
O
O
S
H
N
NH
O
HN
O
Product #
Description
25 mg
100 mg
10267
Biotin-dPEG ®3-benzophenone
$125
$275
Biotin-dPEG ®3-TFPA
A Non-specific dPEG ® Photoaffinity Label
dPEG ® Based Photoaffinity label: Inserts into some C-H bonds using SHORT
UV wavelengths that are less protein friendly, useful for
labeling surfaces!
Product #
Description
25 mg
100 mg
10308
Biotin-dPEG ®3-TFPA
$125
$275
Tel. 866 792-9222
Fax 614 760-9781
81
Miscellaneous Biotinylation Reagents
Biotinoylsarcosine
Product #
Description
1000 mg
10355
Biotinoylsarcosine
$250
Biotinoyl-2-Aminobutyric acid
Product #
Description
1000 mg
10356
Biotinoyl-2-Aminobutyric acid
$250
Tel. 866 792-9222
Fax 614 760-9781
82
Biotin-dPEG ®x-azide
dPEG ® Based Biotinylation Reagent useful for introducing biotin
via a Cu catalyzed Click Reaction
Product #
Description
100 mg
1000 mg
10825
Biotin-dPEG ®7-azide
$200
$1350
$250
$1400
$300
$1600
O
HN
O
NH
S
N
H
O
O
O
O
O
O
O
N3
10784
10787
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), and
specifically see pp. 722-724.
Tel. 866 792-9222
Fax 614 760-9781
83
NHS-biotin
Product #
Description
10205
NHS-biotin
O
100 mg
1000 mg
$50
$150
O
O
NH
HN
O
N
O
S
Bis-dPEG®3-biotin
Product #
Description
50 mg
1000 mg
10325
Bis-dPEG ®3-biotin
$100
$750
Biotin-dPEG ®3-cyanocobalamin
Product #
Description
5 mg
10218
$125
Tel. 866 792-9222
Fax 614 760-9781
84
Product #
Description
5 mg
10218
$125
Tel. 866 792-9222
Fax 614 760-9781
85
References
NHS-dPEG®x-biotin
1.
2.
3.
4.
5.
6.
7.
8.
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Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim, Stuart H. Yuspa. J of Immun. 2008, 181 (2)
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A generalized kinetic model for amine modification of proteins with application to phage display. Xiaofang Jin, Jessica Rose Newton, Stephen
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Accurate Quantification of Cardiovascular Biomarkers in Serum Using Protein Standard Absolute Quantification and Selected Reaction Monitoring. Celine
Huillet, Annie Adrait, Dorothee Lebert, Guillaume Picard, Mathieu Trauchessec, Mathilde Louwagie, Alain Dupuis, Luc Hittinger, Bijan Ghaleh, Philippe
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An Anti-Insulin-like Growth Factor I Receptor AntibodyIs a Potent Inhibitor of Cancer Cell Proliferation. Erin K. Maloney, Jennifer L. McLaughlin, Nancy E.
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An Adsorption Chromatography Assay to Probe Bulk Particle Transport Through Hydrogels. VLADESCU, O. LIELEG, S. JANG, KATHARINA RIBBECK.
Journal of Pharmaceutical Sciences. 2012, 101 (1) pp 4369-442. September 8, 2011. DOI 10.1002/jps.2273.
Mapping of Conformational IgE Epitopes with Peptide-Specific Monoclonal Antibodies Reveals Simultaneous Binding of Different IgE Antibodies to a
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Angelika Stoecklinger, Katharina Marth, Anja Drescher, Josef Thalhamer, Peter Valent, Otto Majdic, Rudolf Valenta. J of Immun. 2011, 186 (9) pp 53335344. March 30, 2009. DOI: 10.4049/jimmunol.1000804.
Bifunctional phage-based pretargeted imaging of human prostate carcinoma. Jessica R. Newton-Northup, Said D. Figueroa, Thomas P. Quinn, Susan L.
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M Cell–Targeted Ocular Immunization: Effect on Immunoglobulins in Tears, Feces, and Serum. Thomas E. Phillips, Jeremy Sharp, Kay Rodgers, and
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Characterization of a mouse amelogenin [A−4]/M59 cell surface receptor. Kevin Tompkins, Anne George, Arthur Veis, Kevin Tompkins, Anne George,
Arthur Veis. Bone. 2006, 38 (2) pp 172-180. October 6, 2005. DOI: 10.1016/j.bone.2005.08.013.
Chemical and biological characterisation of a sensor surface for bioprocess monitoring. Jonathan D. Moore, Miguel A. Perez-Pardo, Jonathan F.
Popplewell, Steve J. Spencer, Santanu Ray, Marcus J. Swann, Alex G. Shard, Walis Jones, Anna Hills, Daniel G. Bracewell. Biosensors and Bioelectronics.
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Classification of protein profiles from antibody microarrays using heat and detergent treatment. Anna Haggmark, Maja Neiman, Kimi Drobin, Martin
Zwahlen, Mathias Uhlen, Peter Nilsson, Jochen M. Schwenk. New Biology. 2012, 29 (5) pp 564-570. June 15, 2012. DOI: 10.1016/j.nbt.2011.10.005.
Comparative protein profiling of serum and plasma using an antibody suspension bead array approach. Jochen M. Schwenk, Ulrika Igel, Bernet S. Kato,
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Detection of botulinum neurotoxins in buffer and honey using a surface plasmon resonance (SPR) sensor. Jon Ladd, Allen D. Taylor, Jiˇr´ı Homola, Shaoyi
Jiang. Science Direct. 2008, 130 (1) pp 129-134. March 14, 2008. DOI: 10.1016/j.snb.2007.07.140.
Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. R. Nicoli, M.
Bartolini, S. Rudaz, V. Andrisano, J.-L. Veuthey. Journal of Chromatography A. 2008, 1206 (1) pp 2-10. June 14, 2008. DOI: 10.1016/j.chroma.2008.05.080.
Engineering of novel tamavidin 2 muteins with lowered isoelectric points and lowered non-specific binding properties. Yoshimitsu Takakura, Naomi Oka,
Hitomi Kajiwara, Masako Tsunashima. Journal of Bioscience and Bioengineering. 2012, 114 (5) pp 485-489. July 12, 2012. DOI:
10.1016/j.jbiosc.2012.06.009.
Fibronectin Type III Domain Based Monobody with High Avidity. Jinzhu Duan, Jinsong Wu, C. Alexander Valencia, Rihe Liu. Biochemistry. 2007, 46 (44) pp
12656-12664. October 12, 2007. DOI: 10.1021/bi701215e.
Mapping the Membrane Topology and Extracellular Ligand Binding Domains of the Retinol Binding Protein Receptor. Riki Kawaguchi, Jiamei Yu, Patrick
Wiita, Mariam Ter-Stepanian, Hui Sun. Biochemistry. 2008, 47 (19) pp 5387-5395. March 25, 2008. DOI: 10.1021/bi8002082.
Large-Scale Identification of Bacteria_Host Crosstalk by Affinity Chromatography: Capturing the Interactions of Streptococcus suis Proteins with Host
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Microstructured layers of spherical biofunctional core-shell nanoparticles provide enlarged reactive surfaces for protein microarrays. Kirsten Borchers,
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Antibody Suspension Bead Arrays within Serum Proteomics. Jochen M. Schwenk, Marcus Gry, Rebecca Rimini, Mathias Uhlén, Peter Nilsson. Journal of
Proteome. 2008, 7 (8) pp 3168-3175. June 28, 2008. DOI: 10.1021/pr700890b.
Tel. 866 792-9222
Fax 614 760-9781
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Michelle Le Brocq, Stefan Rose-John, Kit Ming Lee, Andrew H. Baker, Rachel Wheat, David J. Blackbourn, Robert J. B. Nibbs and Gerard J. Graham.
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A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide
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Major Membrane Protein TDE2508 Regulates Adhesive Potency in Treponema denticola. Yuki Abiko, Keiji Nagano, Yasuo Yoshida, Fuminobu Yoshimura.
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Structurally Defined Nano-scale Sheets from Self-Assembly of Collagen-Mimetic Peptides.
Tao Jiang, Chunfu Xu, Yang Liu, Zheng Liu, Joseph S. Wall, Xiaobing Zuo, Tianquan Lian, Khalid Salaita, Chaoying Ni, Darrin Pochan, Vincent P.
Conticello. Journal of the American Chemical Society. 2014. February 26, 2014. DOI: 10.1021/ja412867z.
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Sensitive Detection of Small Molecule–Protein Interactions on a Metal – Insulator – Metal Label-Free Biosensing Platform Amir Syahir, Kotaro Kajikawa
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Measurement of Inflammatory Cytokine Secretion from Human Monocytes after Inflammasome Activation. Yoshitaka Shirasaki, Asahi Nakahara, Nanako
Shimura, Kazushi Izawa, Nobutake Suzuki, Mai Yamagishi, Jun Mizuno, Tetsushi Sekiguchi, Ryuta Nishikomori, Shuichi Shoji, Osamu Ohara. Royal Society
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Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins. Veronica C. Ardi, Leslie D. Alexander, Victoria A.
Johnson, and Shelli R. McAlpine. ACS Chem. Biol. 2011, 6 (12), pp 1357–1366. September 27, 2011. DOI: 10.1021/cb200203m.
Palmitoylation of superoxide dismutase 1(SOD1) is increased for familial ALS-linked SOD1 mutants. Sarah E. Antinone, Ghanashyam D. Ghadge, TuKiet T.
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NHS-S-S-dPEG®x-biotin
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Site-Specific Labeling of DNA and RNA Using an Efficiently Replicated and Transcribed Class of Unnatural Base Pairs. Young Jun Seo, Denis A. Malyshev,
Thomas Lavergne, Phillip Ordoukhanian, and Floyd E. Romesberg . J. Am. Chem. Soc. 2011, 133 (49) pp 19878–19888. October 8, 2011. DOI:
10.1021/ja207907d.
Noncovalent Assembly of Anti-Dendritic Cell Antibodies and Antigens for Evoking Immune Responses In Vitro and In Vivo. Anne-Laure Flamar, Sandra
Zurawski, Felix Scholz, Ingrid Gayet, Ling Ni, Xiao-Hua Li, Eynav Klechevsky, John Quinn, SangKon Oh, Daniel H. Kaplan, Jacques Banchereau and Gerard
Zurawski. J Immunol. 2012, 189 pp 2645-2655. September 1, 2012 doi: 10.4049/jimmunol.1102390
Biotinylation reagents for the study of cell surface proteins. Giuliano Elia. Proteomics. 2008, 8 (19) pp 4012-4024. April 16, 2008. 10.1002/pmic.200800097.
Thiol-Mediated Anchoring of Ligands to Self-Assembled Monolayers for Studies of Biospecific Interactions. Kunal V. Gujraty, Randolph Ashton, Sridhar
R. Bethi, Sandesh Kate, Christopher J. Faulkner, G. Kane Jennings, and Ravi S. Kane. Langmuir. 2006, 22 (24) pp 10157–10162. October 19, 2006.DOI:
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NHS-dPEG®₄-biotinidase resistant biotin
1.
2.
Biotin Reagents for Antibody Pretargeting. 7. Investigation of Chemically Inert Biotinidase Blocking Functionalities for Synthetic Utility. D. Scott Wilbur,
Donald K. Hamlin, and Ming-Kuan Chyan. Bioconjugate Chem. 2006, 17 (6) pp 1514–1522. October 28, 2006. DOI: 10.1021/bc060084m.
Simultaneous Monitoring of Presynaptic Transmitter Release and Postsynaptic Receptor Trafficking Reveals an Enhancement of Presynaptic Activity in
Metabotropic Glutamate Receptor-Mediated Long-Term Depression. Wei Xu, Yiu Chung Tse, Frederick A. Dobie, Michel Baudry, Ann Marie Craig, Tak
Pan Wong, and Yu Tian Wang. The Journal of Neuroscience. 2013, 33 (13) pp 5867-5877. March 27, 2013. DOI:10.1523/JNEUROSCI.1508-12.2013.
Biotin-dPEG®x-hydrazide
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Chemical labelling of active serum thioester proteins for quantification. Lotta Holm, Gareth L. Ackland, Mark R. Edwards, Ross A. Breckenridge, Robert B.
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Simultaneous Monitoring of Presynaptic Transmitter Release and Postsynaptic Receptor Trafficking Reveals an Enhancement of Presynaptic Activity in
Metabotropic Glutamate Receptor-Mediated Long-Term Depression. Wei Xu, Yiu Chung Tse, Frederick A. Dobie, Michel Baudry, Ann Marie Craig, Tak
Pan Wong, and Yu Tian Wang. The Journal of Neuroscience. 2013, 33 (13) pp 5867-5877. March 27, 2013. DOI:10.1523/JNEUROSCI.1508-12.2013.
Comparing the efficiencies of hydrazide labels in the study of protein carbonylation in human serum albumin. Zafer Ugur & Chelsea M. Coffey & Scott
Gronert. Analytical and Bioanalytical Chemistry. 2012, 404 (5) pp 1399-1411. July 19, 2012. DOI: 10.1007/s00216-012-6235-9.
Development of biosensor-based assays to identify anti-infective oligosaccharides. Jonathan A. Lane, Raj K. Mehra, Stephen D. Carrington, Rita M.
Hickey. Analytical Biochemistry. 2011, 410 (2) pp 200-205. November 25, 2010. DOI: 10.1016/j.ab.2010.11.032.
Transcription Termination Factor Rho Can Displace Streptavidin from Biotinylated RNA. Annie Schwartz, Emmanuel Margeat, A. Rachid Rahmouni, and
Marc Boudvillain. JBC. 2007, 282 (43) pp 31469–31476. October 26, 2007. DOI 10.1074/jbc.M706935200.
WSS25 Inhibits Growth of Xenografted Hepatocellular Cancer Cells in Nude Mice by Disrupting Angiogenesis via Blocking Bone Morphogenetic Protein
(BMP)/Smad/Id1 Signaling. Hong Qiu, Bo Yang, Zhi-Chao Pei, Zhang Zhang and Kan Ding. JBC. 2010, 285 (42) pp 32638–32646. October 15, 2010. doi:
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Development of Robust and Standardized Cantilever Sensors Based on Biotin/Neutravidin Coupling for Antibody Detection. Jiayun Zhang, Hans Peter
Lang, Felice Battiston, Natalija Backmann, Francois Huber and Christoph Gerber. Sensors. 2013, 13 pp5273-5285. April 19, 2013. doi:10.3390/s130405273.
Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol
System. Yu SAKURAI, Hiroto HATAKEYAMA, Hidetaka AKITA, Motoi OISHI, Yukio NAGASAKI, Shiro FUTAKI and Hideyoshi HARASHIMA. Biol. Pharm.
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Miao and Allen J. Bard. Anal. Chem. 2004, 76 (18), pp 5379-5386. August 7, 2004. DOI: 10.1021/ac0495236.
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Tony Taldone, Anna Rodina, Erica M. DaGama
Gomes, Matthew Riolo, Hardik J. Patel, Raul Alonso-Sabadell, Danuta Zatorska, Maulik R. Patel, Sarah Kishinevsky and Gabriela Chiosis. Beilstein J. Org.
Chem. 2013, 9 pp 544-556. March 15, 2013. DOI: 10.3762/bjoc.9.60.
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Korean Chem. Soc.2009, 30 (4) pp 955-958. February 23, 2009.
KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells. Zerrin Kuras, Yeo-Heung Yun, Ameet A. Chimote, Lisa
Neumeier, Laura Conforti. PLoS ONE 7(8), e43859. August 27, 2012. DOI: 10.1371/journal.pone.0043859.
Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand. Wenhao Liu, Andrew B. Greytak,
Jungmin Lee, Cliff R. Wong, Jongnam Park, Lisa F. Marshall, Wen Jiang, Peter N. Curtin, Alice Y. Ting, Daniel G. Nocera, Dai Fukumura, Rakesh K. Jain
and Moungi G. Bawendi. J. Am. Chem. Soc. 2010, 132 (2) pp 472–483. December 21, 2009. DOI: 10.1021/ja908137d.
Automated flow-through amperometric immunosensor for highly sensitive and on-line detection of okadaic acid in mussel sample. Rocio B. Dominguez,
Akhtar Hayat, Audrey Sassolas, Gustavo A. Alonso, Roberto Munoz, Jean-Louis Marty. Elsevier. 2012, (99), pp 232-237, September 15, 2012. DOI:
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Synthesis of Biotinylated r-D-Mannoside or N-Acetyl _-D-Glucosaminoside Decorated Gold Nanoparticles: Study of Their Biomolecular Recognition with
Con A and WGA Lectins. Xiaoze Jiang, Abdelghani Housni, Guillaume Gody, Paul Boullanger, Marie-The´re`se Charreyre, Thierry Delair, and Ravin
Narain. Bioconjugate Chem. 2010, 21 pp 521–530. February 3, 2010. DOI: 10.1021/bc900431p.
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A magnetic bead-based protein kinase assay with dual detection techniques. Guangchang Zhou, Juliesta E. Sylvester, Ding Wua, Darren R. Veach ,
Stephen J. Kron. Analytical Biochemistry. 2011, 1 (408), pp 5-11, January 2011. DOI: 10.1016/j.ab.2010.08.034.
Exploration of Dimensions of Estrogen Potency Parsing Ligand Binding and Coactivator Binding Affinities. M. Jeyakumar, Kathryn E. Carlson, Jillian R.
Gunther, and John A. Katzenellenbogen. Journal of Biological Chemistry. 2011 (286), pp. 12971-12982. February 14, 2011. DOI: 10.1074/jbc.M110.205112.
Probing the Topological Tolerance of Multimeric Protein Interactions: Evaluation of an Estrogen/Synthetic Ligand for FK506 Binding Protein Conjugate.
Terry W. Moore Jillian R. Gunther, and John A. Katzenellenbogen. Bioconjugate Chem. 2010, 21 (10), pp 1880–1889. October 4, 2010. DOI:
10.1021/bc100266v.
Electrochemical Template Synthesis of Multisegment Nanowires: Fabrication and Protein Functionalization. Bridget Wildt, Prashant Mali, and Peter C.
Searson. Langmuir. 2006, 22 (25), pp 10528–10534. September 8, 2006. 10.1021/la061184j.
Biomimetic approach to the formation of gold nanoparticle/silica cor/shell structures and subsequent bioconjugation, Sung Min Kang, Kyung-Bok Lee,
Dong Jin Kim and Insung S Choi. Nanotechnology. 2006, (17), pp. 4719–4725. September 1, 2006. DOI: 10.1088/0957.
An Assay to Quantitate Reducible Cysteines from Nanograms of GST-Fusion Proteins Dixon J. Woodbury, Chris A. Rees, Ammon Thompson, Paul
Meiners, April Adams. Analytical Biochemistry. 2011, 417 (2) pp 165-173. October 15, 2011. DOI: 10.1016/j.ab.2011.06.017.
5’-Sulfhydryl-Modified RNA: Initiator Synthesis, in Vitro Transcription, and Enzymatic Incorporation. Lei Zhang, Lele Sun, Zhiyong Cui, Robert L. Gottlieb
and Biliang Zhang. Bioconjugate Chem.2001, 12 (6) pp 939–948. October 16, 2001. DOI: 10.1021/bc015504g.
Colorimetric multiplexed immunoassay using specific aggregation of antigenic peptide-modified luminous nanoparticles. Toshihiro Ihara, Yasunori Mori,
Takaaki Imamura, Motoko Mukae, Shojiro Tanaka, Akinori Jyo. Science Direct. 2006, 578 (1) pp 11-18. May 4, 2006. DOI: 10.1016/j.aca.2006.04.066.
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm. Suci P, Kang S, Gmür R, Douglas T, Young M.. Antimicrobial
Agents and Chemotherapy. 2010, 54 (6) pp 2489-2496. April 12, 2010. 10.1128/AAC.00059-10.
Manipulation of Carrier Proteins in Antibiotic Biosynthesis, James J. La Clair, Timothy L. Foley, Tracy R. Schegg, Conor M. Regan, and Michael D. Burkart.
Chemistry & Biology. 2004. 11 (2), pp 195-201. February 2004. DOI: 10.1016/j.chembiol.2004.02.010.
Solid Phase 4’-Phosphopantetheinylation: Fungal Thiolation Domains are Targets for Chemoenzymatic Modification, Deirdre Stack, Aisling Frizzell, Karen
Tomkins, and Sean Doyle. Bioconjugate Chem. 2009, 20 (8), pp 1514–1522. July 23, 2009. DOI: 10.1021/bc900071j.
Sugar-Binding Proteins from Fish: Selection of High Affinity “Lambodies” That Recognize Biomedically Relevant Glycans. Xia Hong, Mark Z. Ma, Jeffrey C.
Gildersleeve, Sudipa Chowdhury, Joseph J. Barchi, Jr., Roy A. Mariuzza,∥ Michael B. Murphy, Li Mao and Zeev Pancer. ACS Chem. Biol. 2013, 8 pp
152−160. October 2, 2012. doi.org/10.1021/cb300399s.
Structural characterization and functionalization of engineered spider silk films. Kristina Spieß, Stefanie Wohlrab and Thomas Scheibel. Soft Matter. 2010,
6 (17) pp 4168-4174. June 16, 2010. DOI: 10.1039/b927267d.
High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists. Eileen Fung, Priscilla Sugianto, Jason Hsu, Robert Damoiseaux, Tomas
Ganz, and Elizabeta Nemeth. Mol Pharmacol. 2013, 83 (3) pp 681-690. January 4, 2013. DOI.org/10.1124/mol.112.083428.
Diarylpropionitrile (DPN) Enantiomers: Synthesis and Evaluation of Estrogen Receptor β-Selective Ligands. Vincent M. Carroll, M. Jeyakumar, Kathryn E.
Carlson, and John A. Katzenellenbogen. J. Med. Chem. 2012, 55 (1) pp 528–537. November 28, 2011. DOI: 10.1021/jm201436k.
Self-Assembled Quantum Dot-Bioconjugates: Characterization and Use for Sensing Proteolytic Activity. Igor L. Medintz1, Thomas Pons, Kim E. Sapsford,
Philip E. Dawson and Hedi Mattoussi. Proc. of SPIE. 2008, 6945. April 15, 2008. DOI: 10.1117/12.782174.
Enzyme-independent, orientation-selective conjugation of whole human complement C3 to protein surfaces. Daniel A. Mitchell, Rebecca Ilyas, Alister W.
Dodds, Robert B. Sim. Journal of Immunological Methods. 2008, 337 (1) pp 49-54. June 9, 2008. DOI: 10.1016/j.jim.2008.05.011.
The rotation-coupled sliding of EcoRV. Jasmina Dikic, Carolin Menges, Samuel Clarke, Michael Kokkinidis, Alfred Pingoud, Wolfgang Wende and Pierre
Desbiolles. Nucleic Acids Research. 2012, 40 (9), pp 4064-4070. January 12, 2012. DOI:10.1093/nar/gkr1309.
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor. Clive Metcalfe, Peter Cresswell and A. Neil Barclay.
Open Biology. 2012, 2 (1). January 11, 2012. DOI: 10.1098/rsob.110036.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
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Solid Phase 4′-Phosphopantetheinylation: Fungal Thiolation Domains are Targets for Chemoenzymatic Modification.Deirdre Stack, Aisling Frizzell, Karen
Tomkins, and Sean Doyle. Bioconjugate Chem. 2009, 20 (8) pp 1514–1522. July 23, 2009. DOI: 10.1021/bc900071j.
Attachment of hydrogel microstructures and proteins to glass via thiol-terminated silanes. Jeong Hyun Seo, Dong-Sik Shin, Priam Mukundan, Alexander
Revzin. Colloids and Surfaces B: Biointerfaces. 2012, 98, pp 1–6. October 1, 2012. doi.org/10.1016/j.colsurfb.2012.03.025.
Monitoring a Coordinated Exchange Process in a Four-Component Biological Interaction System: Development of a Time-Resolved Terbium-Based One
Donor/Three-Acceptor Multi-Color FRET System. Sung Hoon Kim, Jillian R. Gunther, and John A. Katzenellenbogen. JACS. 2010 132 (13) pp 4685-4692.
April 7, 2011. DOI:10.1021/ja100248q.
A Set of Time-Resolved Fluorescence Resonance Energy Transfer Assays for the Discovery of Inhibitors of Estrogen Receptor-Coactivator Binding. Jillian
R. Gunther, Yuhong Du, Eric Rhoden, Iestyn Lewis, Brian Revennaugh, Terry W. Moore, Sung Hoon Kim, Raymond Dingledine, Haian Fu and John A.
Katzenellenbogen. Journal of Biomolecular Screening. 2009, 14 (2) pp # 181-195. February 4, 2009. DOI: 10.1177/1087057108329349.
An Anti-Insulin-like Growth Factor I Receptor AntibodyIs a Potent Inhibitor of Cancer Cell Proliferation. Erin K. Maloney, Jennifer L. McLaughlin, Nancy E.
Dagdigian. Cancer Research. 2003, 63 pp 5073-5083. August 15, 2003. DOI:
Biotin-dPEG®x-TFPA
1.
2.
Molded hyaluronic-acid gel as a micro-template for blood capillaries. Ko Sugibayashi, Yoshikazu Kumashiro, Tatsuya Shimizu, Jun Kobayashi, and Teruo
Okano. Journal of biomaterials science. Polymer edition, 2012 May 22, 2012. DOI: 10.1163/156856212X627847.
Elastomeric microparticles for acoustic mediated Bioseparations. Leah M Johnson, Lu Gao, C Wyatt Shields IV, Margret Smith, Kirill Efimenk, Kevin
Cushing, Jan Genzer and Gabriel P López. Journal of Nanobiotechnology. 2013, 11 (22) pp 1-8. June 28, 2013. DOI:10.1186/1477-3155-11-22.
Biotin-dPEG®x-azide
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Sequential Nucleophilic Substitutions Permit Orthogonal Click Functionalization of Multicomponent PEG Brushes. Jin Sha, Ethan S. Lippmann, Jason
McNulty, Yulu Ma, and Randolph S. Ashton. Biomacromolecules. 2013, 14 (9) pp 3294–3303. August 13, 2013. DOI: 10.1021/bm400900r.
Polymer Therapeutics with a Coiled Coil Motif Targeted against Murine BCL1 Leukemia. Robert Pola, Richard Laga, Karel Ulbrich, Irena Sieglová, Vlastimil
Král, Milan Fábry, Martina Kabešová, Marek Kovář, and Michal Pechar. Biomacromolecules. 2013, 14 (3) pp 881–889. February 1, 2013. DOI:
10.1021/bm3019592.
Herpes Simplex Virus 2 Infection Impacts Stress Granule Accumulation. Renée L. Finnen, Kyle R. Pangka, and Bruce W. Banfield. J. Virol. 2012, 86 (15) pp
8119–8130. August 1, 2012. doi:10.1128/JVI.00313-12.
Dendron Avidity Platforms with Orthogonal Focal Point Coupling Site. Daniel Quinn McNerny. University of Michigan Library. 2010. DOI:
www.hdl.handle.net/2027.42/78871.
RGD Dendron bodies; synthetic avidity agents with defined and potentially interchangeable effector sites that can substitute for antibodies. Daniel Q.
McNerny, Jolanta F. Kukowska-Latallo, Douglas G. Mullen, Joseph M. Wallace, Ankur M. Desai, Rameshwer Shukla, Baohua Huang, Mark M. Banaszak
Holl, and James R. Baker Jr. Bioconjugate Chemistry 2009 20 (10) pp 1853-1859 September 14, 2009. DOI:10.1021/bc900217h.
Detection of O -GlcNAc Modi fi cations on Cardiac Myo fi lament Proteins. Genaro A. Ramirez-Correa , Isabel Martinez Ferrando , Gerald Hart and Anne
Murphy. Methods in Molecular Biology. 2013, 1005 (13) pp 157-168. January 1, 2013. DOI: 10.1007/978-1-62703-386-2_13.
Site-Specific Incorporation of Photo-Cross-Linker and Bioorthogonal Amino Acids into Enteric Bacterial Pathogens. Shixian Lin, Zhenrun Zhang, Hao Xu,
Lin Li, She Chen, Jie Li, Ziyang Hao, and Peng R. Chen. J. Am. Chem. Soc. 2011, 133 (50), pp 20581–20587. November 15, 2011. DOI: 10.1021/ja209008w.
Surface Functionalization Using Catalyst-Free Azide-Alkyne Cycloaddition. Alexander Kuzmin, Andrei Poloukhtine, Margreet A. Wolfert, and Vladimir V.
Popik. Bioconjugate Chem. 2010, 21 (11) pp 2076–2085. October 21, 2010. DOI: 10.1021/bc100306u.
Biotin-dPEG®x-cyanocobalamin
1.
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Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates. Green, Damian J.; Pagel, John M.;
Nemecek, Eneida R.; Lin, Yukang; Kenoyer, Aimee; Pantelias, Anastasia; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Rajendran, Joseph G.;
Gopal, Ajay K.; Park, Steven I.; Press, Oliver W. Blood Journal. 2009, 114 (6) pp 1226-1235. March 11, 2009. DOI:10.1182/blood-2009-03-210344.
Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20
radioimmunotherapy of B-cell lymphomas. Pagel, John M.; Lin, Yukang; Hedin, Nathan; Pantelias, Anastasia; Axworthy, Donald; Stone, Diane; Hamlin,
Don K., Wilbur, D. Scott; Press, Oliver W. Blood. 2006, 108 (1) pp 328-336. February 21, 2006. DOI:10.1182/blood-2005-11-4327.
Tel. 866 792-9222
Fax 614 760-9781
Tel. 866 792-9222
Fax 614 760-9781
86
dPEG® based Fluorescent and other Dye Labels
dPEG ® based Fluorescent and other Dye Labels
Lissamine Rhodamine B sulfonamide-dPEG ®4-acid
A fluorescent dPEG ® label (5- and 6-mixed isomers)
Product #
Description
10 mg
10229
Lissamine Rhodamine B sulfonamide-dPEG ®4-acid
$175
DNP-dPEG ®x-NHS ester
Product #
Description
100 mg
1000 mg
10347
DNP-dPEG®4-NHS ester
$200
$1000
$250
$1250
DNP-dPEG®12-NHS ester
10399
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See his
Chapter 19 especially in hapten-carrier chemistry and applications, as well as Chapter 18 on Discrete PEG pegylation reagents, with much of the chapter featuring our
reagents.
Tel. 866 792-9222
Fax 614 760-9781
87
dPEG® based Fluorescent and other Dye Labels
DNP-dPEG ®x-acid
Product #
Description
100 mg
1000 mg
10346
DNP-dPEG®4-acid
$175
$900
$225
$1125
DNP-dPEG®12-acid
10398
References:
Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See his
Chapter 19 especially in hapten-carrier chemistry and applications, as well as Chapter 18 on Discrete PEG pegylation reagents, with much of the chapter featuring our
reagents.
Carboxy Fluorescein-dPEG ®12-NHS ester
Product #
Description
5 mg
10 mg
10885
Carboxy Fluorescein-dPEG®12-NHS ester
$250
$450
Tel. 866 792-9222
Fax 614 760-9781
88
dPEG® Based Reagents for Peptide Modification
dPEG ® Based Reagents for Peptide Modification
Fmoc-N-amido-dPEG ®x-acid
dPEG ® as versatile tool in tailoring peptide struture or for
modifying physical properties...as a SPACER within sequence
or as a end group SPACER/LINKER or modifier!
Product #
Description
100 mg
1000 mg
5000 mg
10243
Fmoc-N-amido-dPEG®2-acid
NA
$175
$550
NA
$275
$700
$100
$250
$700
NA
$300
$850
$125
$350
$1150
10033
O
O
O
N
H
O
O
OH
O
10213
10053
O
O
O
N
H
O
O
O
O
O
H
O
10063
O
O N
H
O
O
O
O
O
O
O
OH
Tel. 866 792-9222
Fax 614 760-9781
89
Fmoc-N-amido-dPEG ®x-acid (cont.)
Product #
Description
10273
O
O
O N
H
O
O
O
O
1000 mg
5000 mg
$150
$600
NA
$150
$650
NA
$250
$900
NA
$300
$1100
NA
O
O
O
100 mg
O
OH
10283
O
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
10313
10903
Fmoc-N-amido-dPEG®x-NHS esters
Product #
Description
100 mg
1000 mg
10994
Fmoc-N-amido-dPEG®4-NHS ester
$125
$325
$175
$675
$185
$725
10995
10996
Tel. 866 792-9222
Fax 614 760-9781
90
Fmoc-N-Lys-(dPEG ®x-biotin)-OH-(acid)
Product #
Description
50 mg
100 mg
1000
mg
10613
Fmoc-N-Lys-(dPEG ®4-biotin)-OH-(acid)
NA
$200
$1000
NA
$300
$1350
S
H
N
HN
O
NH
O
O
O
O
O
H
N
O
O
O
NH
HO
O
Mol. Wt.: 842.01; single compound; dPEG® Spacer is 19.1 atoms and 16 Å
Fmoc-N-Lys-(dPEG ®12-biotin)-OH-(acid)
10615
Tel. 866 792-9222
Fax 614 760-9781
91
t-boc-N-amido-dPEG ®x-acid
dPEG ® as versatile tool in tailoring peptide struture or for modifying
physical properties...as a SPACER within sequence or as a end group
SPACER/LINKER or modifier!
Product #
Description
100 mg
1000 mg
5000 mg
10220
t-boc-N-amido-dPEG®4-acid
$100
$275
$950
$150
$650
upon
request
$175
$750
upon
request
$250
$950
upon
request
$300
$1150
upon
request
10760
10761
10763
Mol. Wt.: 1246.47.; single compound; dPEG® Spacer is 76 atoms and 89.0 Å
10902
Tel. 866 792-9222
Fax 614 760-9781
92
Fmoc-amidooxy-dPEG ®12 acid


among others AND can be incorporated using reagents like the 4-FB-dPEG ®x TFP esters (amine reactive)
Aminooxy-dPEG ®s and peptide synthesis: These reagents can be incorporated as the final step to the Nterminus of the peptide, which with simple deprotection will provide a selective linkage to an aldehyde of a
ketone! Aniline catalysis avails us to both of these. The ketone can be more stable, especially if going into an
aqueous reaction medium.
Product #
Description
100 mg
1000 mg
10849
Fmoc-amidooxy-dPEG®12 acid
$175
$850
References:
Tel. 866 792-9222
Fax 614 760-9781
93
Methoxytrityl-N-dPEG®x-acid
Product #
Description
100 mg
1000 mg
10358
Methoxytrityl-N-dPEG ®4-acid
$125
$300
$175
$650
$200
$750
$275
$1250
10393
10394
10396
Tel. 866 792-9222
Fax 614 760-9781
94
Methoxytrityl-N-dPEG®x-TFP ester
O
NH2
+
TFP
O
dPEG ®x-NH-Mmt
Product #
Description
10751
Methoxytrityl-N-dPEG ®4-TFP ester
O
N
H
O
O
O
O
TFE
dPEG ®x-NH-Mmt
HN
O
O
F
O
F
F
20% DCM
HN
dPEG ®x-NH2
100 mg
1000 mg
$150
$350
$200
$700
$225
$850
H
F
10752
10753
Tel. 866 792-9222
Fax 614 760-9781
95
CBZ-N-amido-dPEG®x-acid
Product #
Description
100 mg
1000 mg
10268
CBZ-N-amido-dPEG ®4-acid
$125
$300
$150
$400
$150
$600
$150
$650
$250
$750
$300
$1000
10066
10276
10286
10316
10906
O
O
N
H
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
Mol. Wt.: 1809.12 single compound; dPEG® Spacer is 111 atoms and 132.7 Å
Tel. 866 792-9222
Fax 614 760-9781
96
Methoxytrityl-S-dPEG®x acid
Tool to add a dPEG ® with a terminal thiol to modify physical
properties or introduce a SPACER end group!
Product #
10301
Description
100 mg
1000 mg
Methoxytrityl-S-dPEG®4-acid
$150
$550
$200
$900
$250
$1050
O
O
S
O
O
O
O
OH
10166
O
S
O
O
O
O
O
O
O
O
O
OH
10846
Additional Reference for these products can be located at the end of this Category
Tel. 866 792-9222
Fax 614 760-9781
97
References
Fmoc-N-amido-dPEG®x-acid
1.
Neutrophil Targeting Heterobivalent SPECT Imaging Probe: cFLFLF-PEG-TKPPR-99mTc. Yi Zhang, Li Xiao, Mahendra D. Chordia, Landon W.
Locke, Mark B. Williams, Stuart S. Berr, and Dongfeng Pan. Bioconjugate Chem. 2010, 21 (10), pp 1788–1793. September 15, 2010. DOI:
10.1021/bc100063a.
2.
Trivalent PEGylated Platform for the Conjugation of Bioactive Compounds. Angela Torres, Carlos Mas-Moruno, Enrique Perez-Paya, Fernando
Albericio, and Miriam Royo. Bioconjugate Chem. 2011, 22 (10), pp 2172–2178. August 25, 2011. DOI: 10.1021/bc100393g.
3.
PulmoBind, an Adrenomedullin-Based Molecular Lung Imaging Tool. Myriam Létourneau, Quang Trinh Nguyen, Francois Harel, Alain Fournier,
and Jocelyn Dupuis. J Nucl Med. 2013, 54 (10) pp 1789-1796. October 1, 2013. doi:10.2967/jnumed.112.118984
4.
Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site. Nathan J. Alves, Matthew M.
Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shawd, Rudolph M. Navari, Tanyel Kiziltepe,
Basar Bilgicer. Biomaterials. 2013, 34 (22) pp 5700–5710. April 16, 2013. doi.org/10.1016/j.biomaterials.2013.03.082.
5.
Solid-phase-assisted synthesis of targeting peptide–PEG–oligo(ethane amino) amides for receptor-mediated gene delivery. Irene Martin,
Christian Dohmen, Carlos Mas-Moruno, Christina Troiber, Petra Kos, David Schaffert, Ulrich Lächelt, Meritxell Teixidó, Michael Günther, Horst
Kessler, Ernest Giralt and Ernst Wagner. Org. Biomol. Chem. 2012,10, PP 3258-3268. February 23, 2012. DOI: 10.1039/C2OB06907E.
6.
Monodispersed DOTA-PEG-Conjugated Anti-TAG-72 Diabody Has Low Kidney Uptake and High Tumor-to-Blood Ratios FResulting in Improved
Cu PET, Lin Li, Fabio Turatti, Desiree Crow, James R. Bading, Anne-Line Anderson, Erasmus Poku, Paul J. Yazaki, Lawrence E. Williams, Debra
Tamvakis, Paul Sanders, David Leong, Andrew Raubitschek, peter J. Hudson, David Colcher, and John E. Shively. Journal of Nuclear Medicine.
2010, 7 (51), pp 1139-1146. June 16, 2010. DOI: 10.2967/jnumed.109.074153.
7.
Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol PeptideLinker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI:
10.1021/nn4033954.
8.
Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation, Kenju Fujii, Junya Nagai, Takeshi
Sawada, Ryko Yumoto, and Mikihisa Takano, Bioconjugate Chem., 2009, 20 (8), pp 1553–1558 July 2, 2009. DOI: 10.1021/bc900094g.
9.
A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes.
Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI:
10.1021/nn305663e.
10.
Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson ; Andrew M. Dattelbaum ; Harshini
Mukundan ;Dominique N. Price ; W. Kevin Grace ; Basil I. Swanson. Frontiers in Pathogen Detection: From Nanosensors to Systems., 2009, Proc.
Of SPIE 7167. 71670q-1 February 18, 2009. 10.1117/12.809383.
11.
Optimization of Xenon Biosensors for Detection of Protein Interactions. Thomas J. Lowery, Sandra Garcia, Lana Chavez, E. Janette Ruiz, Tom Wu,
Thierry Brotin, Jean-Pierre Dutasta, David S. King, Peter G. Schultz, Alex Pines, and David E. Wemmer. ChemBioChem. 2006, 7 (1), pp 65-73.
DOI: 10.1002/cbic.200500327.
12.
Development of Peptide Nucleic Acid Probes for Detection of the HER2 Oncogene.
Belhu Metaferia., Jun S. Wei., Young K. Song, Jennifer Evangelista, Konrad Aschenbach, Peter Johansson, Xinyu Wen, Qingrong Chen, Albert
Lee, Heidi Hempel, Jinesh S. Gheeya, Stephanie Getty, Romel Gomez, Javed Khan. PLoS ONE. 2012, 8 (4) e58870. April 10, 2013. DOI:
10.1371/journal.pone.0058870.
13.
Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs. Gary R. Matyas,
Alexander V. Mayorova, Kenner C. Rice, Arthur E. Jacobson, Kejun Cheng, Malliga R. Iyer, Fuying Li, Zoltan Becka, Kim D. Janda, Carl R. Alvinga.
Vaccine. 2013, 31 (26) pp 2804-2810. June 10, 2013. doi.org/10.1016/j.vaccine.2013.04.027.
14.
Neutrophil Targeting Heterobivalent SPECT Imaging Probe: cFLFLF-PEG-TKPPR-99mTc. Yi Zhang, Li Xiao, Mahendra D. Chordia, Landon W.
Locke, Mark B. Williams, Stuart S. Berr, and Dongfeng Pan. Bioconjugate Chem., 2010, 21 (10), pp 1788–1793 September 15, 2010. DOI:
10.1021/bc100063a.
15.
Calcium Condensed LABL-TAT Complexes Effectively Target Gene Delivery to ICAM-1 Expressing Cells Supang Khondee, Abdulgader Baoum,
Teruna J. Siahaan, and Cory Berkland. Mol. Pharmaceutics. 2011, 8 (3), pp 788–798. April 7, 2011. DOI: 10.1021/mp100393j.
16.
Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance
and Tumor Uptake with Improved 64-Copper PET Imaging. Lin Li,Desiree Crow, Fabio Turatti, James R. Bading, Anne-Line Anderson, Erasmus
Poku, Paul J. Yazaki, Jenny Carmichael, David Leong, Michael P. Wheatcroft,Andrew A. Raubitschek, Peter J. Hudson,David Colcher, and John E.
Shively.Bioconjugate Chem., 2011, 22 (4), pp 709–716 March 12, 2011. DOI: 10.1021/bc100464e.
17.
Expanding the Scope of Biocatalysis: Oxidative Biotransformations on Solid-Supported Substrates. Sarah J. Brooks, Lydie Coulombel, Disha
Ahuja, Douglas S. Clark, and Jonathan S. Dordick. Advanced Synthesis & Catalysis. 2008, 350 (10), pp 1517–1525. July 7, 2008.
DOI:10.1002/adsc.200800188.
18.
Evaluation of 99mTc-Labeled Cyclic RGD Peptide with a PEG4 Linker for Thrombosis Imaging: Comparison with DMP444. Wei Fang, Jia He,
Young-Seung Kim, Yang Zhou, and Shuang Liu. Bioconjugate Chem. 2011, 22 (8), pp 1715–1722. July 24, 2011. DOI: 10.1021/bc2003742.
19.
Flexible antibodies with nonprotein hinges. Daniel J. Capon, Naoki Kaneko, Takayuki Yoshimori, Takashi Shimada, Florian M. Wurm, Peter K.
Hwang, Xiaohe Tong, Staci A. Adams, Graham Simmons, Taka-Aki Sato and Koichi Tanaka. The Japan Academy Series B Physical and Biological
Sciences.. 2011, 87 (9), pp 603-616. November 11, 2011. DOI: 10.2183/pjab.87.603.
20.
Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Nathan J Alves,
Tanyel Kiziltepe, and Basar Bilgicer. Langmuir. 2012, 28 (25) pp 9640-9648. May 21, 2012. DOI: 10.1021/la301887s.
21.
Precise and multifunctional conjugates for targeted siRNA delivery. Prof. Dr. Ernst Wagner Prof. Dr. Wolfgang Friess. Dissertation zur Erlangung
des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München. April 27, 2012.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
22.
Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing. Christian Dohmen, Thomas Fröhlich, Ulrich Lächelt, Ingo Röhl, HansPeter Vornlocher, Philipp Hadwiger and Ernst Wagner. Molecular Therapy–Nucleic Acids, 2011, 1 (1), F7, December 27, 2011. DOI:
10.1038/mtna.2011.10.
23.
Photocleavable Peptide-Conjugated Magnetic Beads for Protein Kinase Assays by MALDI-TOF MS. Guangchang Zhou, Xiaoliang Yan, Ding Wu,
and Stephen J. Kron. Bioconjugate Chem. 2010, 21 (10), pp 1917–1924. September 22, 2010. DOI: 10.1021/bc1003058.
24.
PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.
25.
Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. Xiao L, Zhang Y, Liu Z, Yang M,
Pu L, Pan D. Bioorganic & Medicinal Chemistry Letters. 2010, 20 (12) pp 3515-3517. June 15, 2010. 10.1016/j.bmcl.2010.04.136.
26.
Radionuclides in Targeted Therapy of Cancer. Adina Elena STANCIU. Rev. Roum. Chim. 2012, 57 (1) pp 5-13. May 27, 2011. DOI:
http://web.icf.ro/rrch/.
27.
2-Mercaptoacetylglycylglycyl (MAG2) as a Bifunctional Chelator for 99mTc-Labeling of Cyclic RGD Dimers: Effect of Technetium Chelate on
Tumor Uptake and Pharmacokinetics. Jiyun Shi, Young-Seung Kim, Sudipta Chakraborty, Bing Jia, Fan Wang and Shuang Liu. Bioconjugate
Chem. 2009, 20 (8) pp 1559–1568. July 15, 2009. DOI: 10.1021/bc9001739.
28.
99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging. Shundong Ji, Andrzej Czerwinski, Yang
Zhou, Guoqiang Shao, Francisco Valenzuela, Paweł Sowiński, Satendra Chauhan, Michael Pennington, and Shuang Liu. Mol. Pharmaceutics. 2013,
10 (9) pp 3304–3314. July 22, 2013. DOI: 10.1021/mp400085d.
29.
Impact of PKM Linkers on Biodistribution Characteristics of the 99mTc-Labeled Cyclic RGDfK Dimer. Shuang Liu, Zhengjie He, Wen-Yuan Hsieh,
Young-Seung Kim, and Young Jiang. Bioconjugate Chem. 2006, 17 (6) pp 1499–1507. November 1, 2006. DOI: 10.1021/bc060235l.
30.
Two 90Y-Labeled Multimeric RGD Peptides RGD4 and 3PRGD2 for Integrin Targeted Radionuclide Therapy. Zhaofei Liu, Jiyun Shi, Bing Jia, Zilin
Yu, Yan Liu, Huiyun Zhao, Fang Li, Jie Tian, Xiaoyuan Chen, Shuang Liu, and Fan Wang.Two 90Y-Labeled Multimeric RGD Peptides RGD4 and
3PRGD2 for Integrin Targeted Radionuclide Therapy. Zhaofei Liu, Jiyun Shi, Bing Jia, Zilin Yu, Yan Liu, Huiyun Zhao, Fang Li, Jie Tian, Xiaoyuan
Chen, Shuang Liu, and Fan Wang. Mol. Pharmaceutics. 2011, 8 (2) pp 591–599. January 19, 2011. DOI: 10.1021/mp100403y.
31.
Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate
Cancer Model. Jered C. Garrison, Tammy L. Rold, Gary L. Sieckman, Farah Naz, Samantha V. Sublett, Said Daibes Figueroa, Wynn A. Volkert and
Timothy J. Hoffman. Bioconjugate Chem. 2008, 19 (9) pp 1803–1812. August 20, 2008. DOI: 10.1021/bc8001375.
32.
Novel Synthetic Route to Peptide-Capped Gold Nanoparticles, Takeshi Serizawa, Yu Hirai, and Mamoru Aizawa. Langmuir. 2009, 25 (20), pp
12229–12234. September 21, 2009. DOI: 10.1021/la9021799.
33.
Improving Tumor Uptake and Pharmacokinetics of 64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3 and PEG4 Linkers. Jiyun Shi, YoungSeung Kim, Shizhen Zhai, Zhaofei Liu, Xiaoyuan Chen and Shuang Liu. Bioconjugate Chem. 2009, 20 (4) pp 750–759. March 25, 2009. DOI:
10.1021/bc800455p.
34.
Improving Tumor-Targeting Capability and Pharmacokinetics of 99mTc-Labeled Cyclic RGD Dimers with PEG4 Linkers. Lijun Wang, Jiyun Shi,
Young-Seung Kim, Shizhen Zhai, Bing Jia, Huiyun Zhao, Zhaofei Liu, Fan Wang, Xiaoyuan Chen and Shuang Liu. Mol. Pharmaceutics. 2009, 6 (1)
pp 231–245. December 9, 2008. DOI: 10.1021/mp800150r.
35.
Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.
Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. Biochem. J. 2013, 449 pp 91–99. October 11, 2011. doi:10.1042/BJ20121088.
36.
Controlling HBV Replication in Vivo by Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles, Sergio Carmona, Michael R.
Jorgensen, Soumia Kolli, Carol Crowther, Felix H. Salazar, Patricia L. Marion, Masato Fujino, Yukikazu Natori, Maya Thanou, Patrick Arbuthnot,
and Andrew D. Miller. Mol. Pharmaceutic., 2009, 6 (3), pp 706–717. January 21,2009. DOI: 10.1021/mp800157x.
37.
Tumor Uptake of the RGD Dimeric Probe 99mTc-G3-2P4-RGD2 is Correlated with Integrin rv_3 Expressed on both Tumor Cells and
Neovasculature. Zhaofei Liu, Bing Jia, Jiyun Shi, Xiaona Jin, Huiyun Zhao, Fang Li, Shuang Liu, and Fan Wang. Bioconjugate Chem. 2010, 21 (3)
pp 548-555. February 25, 2010. DOI: 10.1021/bc900547d.
38.
Hepatocyte Targeting of Nucleic Acid Complexes and Liposomes by a T7 Phage p17 Peptide. So C. Wong, Darren Wakefield, Jason Klein, Sean
D. Monahan, David B. Rozema, David L. Lewis, Lori Higgs, James Ludtke, Alex V. Sokoloff, and Jon A. Wolff. Mol. Pharm. 2006, 3 (4) pp 386-397.
March 28, 2006. DOI: 10.1021/mp050108r.
39.
Spring-Loaded Model Revisited: Paramyxovirus Fusion Requires Engagement of a Receptor Binding Protein beyond Initial Triggering of the
Fusion Protein. Matteo Porotto, Ilaria DeVito, Samantha G. Palmer, Eric M. Jurgens, Jia L. Yee, Christine C. Yokoyama, Antonello Pessi and Anne
Moscona. J. Virol. 2011, 85 (24) pp 12867-12880. DOI: 10.1128/JVI.05873-11.
40.
Optical Imaging of Integrin αv β3 Expression with Near-Infrared Fluorescent RGD Dimer with Tetra(ethylene glycol) Linkers. Zhaofei Liu,
Shuanglong Liu, Gang Niu, Fan Wang, Shuang Liu, Xiaoyuan Chen. Mol Imaging. 2010, 9 (1) pp 21-29. February 1, 2010. DOI:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629979/.
41.
Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson, Andrew M. Dattelbaum, Harshini Mukundan,
Dominique N. Price, W. Kevin Grace, Basil I. Swanson. Spie Digital Library, 2010, 7553. January 23, 2010. DOI: 10.1117/12.809383.
42.
Species Differences of Bombesin Analog Interactions with GRP-R Define the Choice of Animal Models in the Development of GRP-R-Targeting
Drugs. Theodosia Maina, PhD; Berthold A. Nock, PhD; Hanwen Zhang, Anastasia Nikolopoulou, Msci, Beatrice Waser, PhD; Jean Claude Reubi,
MD; and Helmut R. Maecke, PhD. Journal of Nuclear Medicine. 2005, 46 (5) pp. 823-830. January 23, 2005.
43.
Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Michael W. Handlogten, Tanyel Kiziltepe, Demetri T. Moustakas, and
Basxar Bilgicer. Chemistry & Biology. 2011, 18 (9) pp 1179–1188. September 23, 2011. DOI 10.1016/j.chembiol.2011.06.012.
44.
Functional PEG-Modified Thin Films for Biological Detection, Aaron S. Anderson, Andrew M. Dattelbaum, Gabriel A. Montano, Dominique N.
Price, Jurgen G. Schmidt, Jennifer S. Martinez, W. Kevin Grace, Karen M. Grace, and Basil I. Swanson. Langmuir. 2008, 24 (5), pp 2240–2247.
January 30, 2008. DOI: 10.1021/la7033438.
Tel. 866 792-9222
Fax 614 760-9781
References (cont.)
45.
Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin, Shin-ichi Sato,
Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp
873–880. January 4, 2007. DOI: 10.1021/ja0655643.
Fmoc-N-amido-dPEG®x-NHS ester
1.
Design of a modular tetrameric scaffold for the synthesis of membrane-localized D-peptide inhibitors of HIV-1 entry. J. Nicholas Francis, Joseph
S Redman, Debra M Eckert, and Michael S. Kay. Bioconjugate Chemistry, 2012, 23 (6), pp 1252-1258, May 1, 2012. DOI: 10.1021/bc300076f.
Lipoamido-dPEG®x-acid
1.
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging. Wenhao Liu, Mark Howarth, Andrew B. Greytak, Yi Zheng, Daniel G.
Nocera, Alice Y. Ting, and Moungi G. Bawendi. J. Am. Chem. Soc. 2008, 130 (4) pp 1274–1284. January 5, 2008. DOI: 10.1021/ja076069p.
Fmoc-N-amido-dPEG®x-acid
1.
New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging, Beata
Jastrzabska, Rejean Lebel, Helene Therriault, J. Oliver McIntyre, Emanuel Escher, Briggitte Guerin, Benoit Paquette, Witold A. Neugebauer, and
Martin Lepage. J. Med. Chem. 2009, 52 (6), pp 1576–1581. February 19, 2009. DOI: 10.1021/jm801411h.
2.
A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes.
Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. ACS Nano. 2013, 7 (4) pp 2935–2947. February 19, 2013. DOI:
10.1021/nn305663e.
3.
A Non-Chromatographic Method for the Purification of a Bivantly Active Monoclonal IgG Antibody from Biological Fluids, Basar Bilgicer, Samuel
W. Thomas III, Bryan F. Shaw, George K. Kaufman, Vijay M. Krishnamurthy, Lara A. Estroff, Jerry Yang, and George M. Whitesides. JACS. 2009,
131 (26), pp 9361–9367. June 17, 2009. DOI: 10.1021/ja9023836.
4.
Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation. Michael W. Handlogten, Tanyel
Kiziltepe, Nathan J. Alves, and Basar Bilgicer. ACS Chem. Biol., 2012, 7 (11) pp 1796–1801. August 10, 2012. DOI: 10.1021/cb300193f.
5.
Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate
Cancer Model. Jered C. Garrison, Tammy L. Rold, Gary L. Sieckman, Farah Naz, Samantha V. Sublett, Said Daibes Figueroa, Wynn A. Volkert and
Timothy J. Hoffman. Bioconjugate Chem. 2008, 19 (9) pp 1803–1812. August 20, 2008. DOI: 10.1021/bc8001375.
6.
PEG-Peptide Conjugates. Ian W Hamley. Biomacromolecules. 2014. April 1, 2014. DOI: 10.1021/bm500246w.
7.
Design of a Heterobivalent Inhibitor of Allergy and More Physiologically Relevant Allergy Models. Michael William Handlogten. University of
Notre Dame. 2013, March 28, 2013. DOI: etd-04022013-155410.
8.
Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Michael W. Handlogten, Tanyel Kiziltepe, Demetri T. Moustakas, and
Basxar Bilgicer. Chemistry & Biology. 2011, 18 (9) pp 1179–1188. September 23, 2011. DOI 10.1016/j.chembiol.2011.06.012.
9.
B-Peptide Conjugates: Syntheses and CD and NMR Investigations of B/a-Chimeric Peptides, of a DPA-B-Decapeptide, and of a PEGylated bHeptapeptide. James Gardiner, Raveendra I. Mathad, Berhard Jaun, Jurg V. Schreiber, Oliver Flogel, and Dieter Seebach. Helvetica Chimica
Acta. 2009, 92 (12) pp 2698-2721. December 17, 2009. DOI: 10.1002/hlca.200900325.
10.
Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.
Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. Biochem. J. 2013, 449 pp 91–99. October 11, 2011. doi:10.1042/BJ20121088.
11.
Novel Solubility-Switchable MRI Agent Allows the Noninvasive Detection of Matrix Metalloproteinase-2 Activity In Vivo in a Mouse Model.
Rejean Lebel, Beata Jastrzebska, Helene Therriault, Marie-Michele Cournoyer, J. Oliver McIntyre, Emanuel Escher, Witold Neugebauer, Benoit
Paquette, and Martin Lepage. Magnetic Resonance in Medicine, 2008, 60 (5) pp 1056–1065. November 1,2008. DOI: 10.1002/mrm.21741.
12.
Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA). Duanwen Shen., Fei Xie2, W. Barry
Edwards. PLoS One. 2013, 8 (7), e68339. July 25, 2013. DOI: 10.1371/journal.pone.0068339.
13.
Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol PeptideLinker Length. Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer. ACS Nano. 2013, 7 (9) pp 8115–8127. August 29, 2013. DOI:
10.1021/nn4033954.
14.
Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin, Shin-ichi Sato,
Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Quian Mao, Yoshinori Kawazoe, and Motonari Uesugi. J. Am. Chem. Soc. 2007, 129 (4), pp
873–880. January 4, 2007. DOI: 10.1021/ja0655643.
15.
Determination of bacterial viability by selective capture using surface-bound siderophores. Mark L. Wolfenden, Rama M. Sakamuri, Aaron S.
Anderson, Lakshman Prasad, Jurgen G. Schmidt, Harshini Mukundan. Advances in Biological Chemistry. 2012, (2) pp 396-402 September 30,
2012. DOI: 10.4236/abc.2012.24049.
16.
A Synthetic Trivalent Hapten that Aggregates Anti-2,4-DNP IgG into Bicyclic Trimers. Başar Bilgiçer, Demetri T. Moustakas, and George M.
Whitesides. Journal of the American Chemical Society. 2007, 129 (12,) pp 3722-3728. March 28 2007. DOI: 10.1021/ja067159h.
17.
Multifunctional nanoparticles as simulants for a gravimetric Immunoassay. Scott A. Miller, Leslie A. Hiatt, Robert G. Keil, David W. Wright, and
David E. Cliffel. Analytical and Bioanalytical Chemistry. 2011, 399 (3) pp 1021-1029 January 1, 2011. DOI:10.1007/s00216-010-4419-8.
18.
Mechanistic Studies of a Peptidic GRP78 Ligand for Cancer Cell-Specific Drug Delivery. Ying Liu, Sebastian C.J. Steiniger, YoungSoo Kim,
Gunnar F. Kaufmann, Brunhilde Felding-Habermann, and Kim D. Janda. Molecular Pharmaceutics 2007 4(3) p 435-447. January 2007.
DOI:10.1021/mp060122j.
19.
Design and Synthesis of Multifunctional Gold Nanoparticles Bearing Tumor-Associated Glycopeptide Antigens as Potential Cancer Vaccines.
Raymond P. Brinãs, Andreas Sundgren, Padmini Sahoo, Susan Morey, Kate Rittenhouse-Olson, Greg E. Wilding, Wei Deng, and Joseph J.
Barchi, Jr. Bioconjugate Chem. 2012, 23 (8), pp 1513-1523. July 19, 2012. DOI: 10.1021/bc200606s.
Tel. 866 792-9222
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References (cont.)
20.
Photocleavable Peptide-Oligonucleotide Conjugates for Protein Kinase Assays by MALDI-TOF MS. Guangchang Zhou, Faraz Khan, Qing Dai,
Juliesta E Sylvester and Stephen J Kron. Molecular BioSystems. 2012, 8 (9), pp 2395-2404. June 13, 2012. DOI: 10.1039/C2MB25163A.
21.
Design of a modular tetrameric scaffold for the synthesis of membrane-localized D-peptide inhibitors of HIV-1 entry. J. Nicholas Francis, Joseph
S Redman, Debra M Eckert, and Michael S. Kay. Bioconjugate Chemistry. 2012, 23 (6), pp 1252-1258. May 1, 2012. DOI: 10.1021/bc300076f.
22.
Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting. Jieming
Gao, Peiming Chen, Yashveer Singh, Xiaoping Zhang, Zoltan Szekely, Stanley Stein, and Patrick J. Sinko. Bioconjugate Chem. 2013, 24 (8) pp
1332–1344. June 29, 2013. DOI: 10.1021/bc400011v.
Methoxytrityl-S-dPEG®x-acid
1.
Gold Nanoparticles Functionalized with Peptides for Specific Affinity Aggregation Assays of Estrogen Receptors and Their Agonists. Yoshiyuki
Takatsuji, Shinya Ikeno and Tetsuya Haruyama. Sensors. 2012, 12 (4), pp 4952-4961. April 18, 2012. DOI: 10.3390/s120404952.
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dPEG® Reagents for Nucleic Acids
dPEG ® Reagents for Nucleic Acids
Amino-dPEG ®12-ODMT
Product #
Description
100 mg
1000 mg
10342
Amino-dPEG®12-ODMT
$225
$900
Mol. Wt.: 848.03; Single compound: dPEG® Spacer is 38 atoms and 43.9 Å
Tel. 866 792-9222
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99
INDEX
10000 .................................................................................. 5
10007 ................................................................................ 73
10008 ................................................................................ 73
10009 ................................................................................ 73
10011 ................................................................................ 44
10014 ................................................................................ 50
10015 ................................................................................ 53
10033 ................................................................................ 89
10041 ................................................................................ 69
10043 ................................................................................ 70
10044 ................................................................................ 70
10053 ................................................................................ 89
10061 ................................................................................ 36
10063 ................................................................................ 89
10064 ................................................................................ 45
10065 ................................................................................ 46
10066 ................................................................................ 96
10067 ................................................................................ 21
10081 ................................................................................ 43
10082 ................................................................................ 43
10085 ................................................................................ 53
10092 ................................................................................ 54
10109 ................................................................................ 63
10119 ................................................................................ 63
10127 ................................................................................ 63
10140 ................................................................................ 63
10142 ................................................................................ 14
10143 ................................................................................ 13
10144 ................................................................................ 13
10147 ................................................................................ 13
10148 ................................................................................ 13
10149 ................................................................................ 13
10156 ................................................................................ 41
10160 ................................................................................ 41
10166 ................................................................................ 97
10170 ................................................................................ 39
10171 ................................................................................ 39
10172 ................................................................................ 60
10175 ................................................................................ 20
10177 ................................................................................ 65
10180 ................................................................................ 35
10181 ................................................................................ 34
10182 ................................................................................ 35
10183 ................................................................................ 28
10184 ................................................................................ 34
10185 ................................................................................ 38
10188 ................................................................................ 34
10193 ................................................................................ 77
10194 ................................................................................ 74
10195 ................................................................................ 80
10196 ................................................................................ 77
10197 ................................................................................ 72
10198 ................................................................................ 71
10199 ................................................................................ 72
10200 ................................................................................ 71
10201 .................................................................................80
10202 .................................................................................75
10203 .................................................................................75
10204 .................................................................................75
10205 .................................................................................84
10208 .................................................................................35
10210 .................................................................................47
10211 .................................................................................12
10213 .................................................................................89
10214 .................................................................................45
10215 .................................................................................60
10217 .................................................................................65
10218 ...........................................................................84, 85
10219 .................................................................................76
10220 .................................................................................92
10221 .................................................................................36
10223 .................................................................................38
10224 .................................................................................51
10225 .................................................................................60
10226 .................................................................................62
10229 .................................................................................87
10230 .................................................................................55
10232 .................................................................................66
10234 .................................................................................14
10236 .................................................................................55
10237 .................................................................................64
10240 .................................................................................39
10243 .................................................................................89
10244 .................................................................................21
10245 .................................................................................55
10246 .................................................................................52
10247 .................................................................................28
10249 .................................................................................39
10250 .................................................................................39
10251 .................................................................................17
10252 .................................................................................17
10254 .................................................................................41
10256 .................................................................................41
10259 .................................................................................41
10260 .................................................................................12
10261 .................................................................................41
10262 .................................................................................12
10264 .................................................................................36
10265 .................................................................................46
10266 .................................................................................45
10267 .................................................................................81
10268 .................................................................................96
10269 .................................................................................62
10271 .................................................................................36
10273 .................................................................................90
10274 .................................................................................45
10275 .................................................................................46
10276 .................................................................................96
10277 .................................................................................21
10278 .................................................................................20
10281 .................................................................................36
10283 .................................................................................90
10284 .................................................................................45
Tel. 866 792-9222
Fax 614 760-9781
100
10285 ................................................................................ 46
10286 ................................................................................ 96
10287 ................................................................................ 21
10288 ................................................................................ 20
10289 ................................................................................ 25
10298 ................................................................................ 20
10301 ................................................................................ 97
10304 ................................................................................ 12
10305 ................................................................................ 18
10307 ................................................................................ 18
10308 ................................................................................ 81
10311 ................................................................................ 36
10313 ................................................................................ 90
10314 ................................................................................ 45
10315 ................................................................................ 46
10316 ................................................................................ 96
10317 ................................................................................ 22
10318 ................................................................................ 20
10319 ................................................................................ 25
10320 ................................................................................ 55
10323 ................................................................................ 65
10324 ................................................................................ 14
10325 ................................................................................ 84
10326 ................................................................................ 14
10327 ................................................................................ 12
10328 ................................................................................ 14
10330 ................................................................................ 37
10331 ................................................................................ 37
10332 ................................................................................ 37
10334 ................................................................................ 37
10337 ................................................................................ 37
10338 ................................................................................ 46
10339 ................................................................................ 14
10340 ................................................................................ 40
10342 ................................................................................ 99
10346 ................................................................................ 88
10347 ................................................................................ 87
10348 ................................................................................ 17
10355 ................................................................................ 82
10356 ................................................................................ 82
10358 ................................................................................ 94
10361 ................................................................................ 61
10362 ................................................................................ 19
10363 ................................................................................ 19
10364 ................................................................................ 19
10373 ................................................................................ 49
10374 ................................................................................ 48
10375 ................................................................................ 49
10376 ................................................................................ 48
10377 ................................................................................ 49
10378 ................................................................................ 48
10379 ................................................................................ 48
10380 ................................................................................ 49
10393 ................................................................................ 94
10394 ................................................................................ 94
10396 ................................................................................ 94
10397 ................................................................................ 60
10398 ................................................................................ 88
10399 ................................................................................ 87
10400 .................................................................................23
10401 .................................................................................15
10402 .................................................................................16
10406 .................................................................................26
10409 .................................................................................74
10410 .................................................................................23
10411 .................................................................................15
10412 .................................................................................16
10416 .................................................................................26
10420 .................................................................................23
10421 .................................................................................15
10422 .................................................................................16
10424 .................................................................................19
10426 .................................................................................26
10453 .................................................................................23
10454 .................................................................................15
10455 .................................................................................16
10456 .................................................................................26
10458 .................................................................................15
10482 .................................................................................10
10484 ...................................................................................9
10492 .................................................................................24
10501 .................................................................................56
10502 .................................................................................57
10503 .................................................................................56
10505 .................................................................................56
10510 .................................................................................59
10511 .................................................................................59
10512 .................................................................................57
10513 .................................................................................57
10514 .................................................................................57
10522 ...........................................................................58, 61
10523 ...........................................................................58, 61
10524 ...........................................................................58, 61
10525 ...........................................................................58, 61
10526 ...........................................................................58, 61
10531 .................................................................................27
10532 .................................................................................27
10534 .................................................................................27
10536 .................................................................................27
10540 .................................................................................27
10541 .................................................................................40
10542 .................................................................................40
10543 .................................................................................40
10544 .................................................................................40
10613 .................................................................................91
10615 .................................................................................91
10630 .................................................................................67
10631 .................................................................................68
10641 .................................................................................30
10642 .................................................................................30
10643 .................................................................................30
10698 .................................................................................55
10699 .................................................................................51
10717 .................................................................................38
10719 .................................................................................38
10722 .................................................................................38
10723 .................................................................................55
10724 .................................................................................51
Tel. 866 792-9222
Fax 614 760-9781
101
10725 ................................................................................ 55
10726 ................................................................................ 51
10728 ................................................................................ 17
10745 ................................................................................ 25
10746 ................................................................................ 25
10751 ................................................................................ 95
10752 ................................................................................ 95
10753 ................................................................................ 95
10760 ................................................................................ 92
10761 ................................................................................ 92
10763 ................................................................................ 92
10773 ................................................................................ 72
10774 ................................................................................ 71
10776 ................................................................................ 72
10784 ................................................................................ 83
10785 ................................................................................ 80
10786 ................................................................................ 77
10787 ................................................................................ 83
10792 ................................................................................ 29
10793 ................................................................................ 29
10794 ................................................................................ 29
10799 ................................................................................ 33
10800 ................................................................................ 33
10801 ................................................................................ 33
10804 ................................................................................ 33
10806 ................................................................................ 31
10807 ................................................................................ 31
10808 ................................................................................ 31
10811 ................................................................................ 31
10814 ................................................................................ 30
10817 ................................................................................ 32
10819 ................................................................................ 32
10820 ................................................................................ 32
10822 ................................................................................ 32
10825 ................................................................................ 83
10826 ................................................................................ 77
10828 ................................................................................ 32
10846 ................................................................................ 97
10849 ................................................................................ 93
10850 ................................................................................ 28
10851 ................................................................................ 35
10852 ................................................................................ 34
10866 ................................................................................ 49
10867 ................................................................................ 48
10868 ................................................................................ 39
10869 ................................................................................ 39
10885 ................................................................................ 88
10894 ................................................................................ 17
10895 ................................................................................ 17
10898 ................................................................................ 18
10899 ................................................................................ 18
10901 ................................................................................ 36
10902 ................................................................................ 92
10903 ................................................................................ 90
10906 ................................................................................ 96
10907 ................................................................................ 22
10908 ................................................................................ 20
10909 ................................................................................ 14
10910 ................................................................................ 12
10918 .................................................................................20
10920 .................................................................................12
10929 .................................................................................18
10930 .................................................................................18
10931 .................................................................................25
10932 .................................................................................25
10939 .................................................................................41
10942 .................................................................................17
10953 .................................................................................55
10954 .................................................................................52
10955 .................................................................................55
10956 .................................................................................52
10957 .................................................................................69
10958 .................................................................................69
10961 .................................................................................47
10962 .................................................................................47
10967 .................................................................................55
10968 .................................................................................52
10978 .................................................................................55
10979 .................................................................................52
10980 .................................................................................54
10981 .................................................................................53
10982 .................................................................................53
10983 .................................................................................54
10984 .................................................................................54
10985 .................................................................................54
10987 .................................................................................53
10988 .................................................................................51
10994 .................................................................................90
10995 .................................................................................90
10996 .................................................................................90
11024 ...................................................................................6
11025 ...................................................................................6
11026 ...................................................................................6
11027 ...................................................................................6
11028 ...................................................................................7
11029 ...................................................................................7
11100 .................................................................................78
11102 .................................................................................78
11106 .................................................................................79
11112 .................................................................................64
11135 .................................................................................44
11400 .................................................................................23
11401 .................................................................................15
11402 .................................................................................16
11406 .................................................................................26
11449 .................................................................................10
11451 ...................................................................................9
11471 ...................................................................................9
11474 .................................................................................10
11486 .................................................................................10
11487 ...................................................................................9
11630 .................................................................................11
11633 .................................................................................11
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102
4-formyl-benzamido-dPEG®12-TFP ester ........................ 43
4-formyl-benzamido-dPEG®24-TFP ester ........................ 43
A
Acid-dPEG®13-NHS ester................................................. 63
Acid-dPEG®25-NHS ester................................................. 63
Acid-dPEG®5-NHS ester .................................................. 63
Acid-dPEG®9-NHS ester .................................................. 63
Amino-dPEG®11-ONH-t-boc ........................................... 64
Amino-dPEG®12-acid ....................................................... 21
Amino-dPEG®12-alcohol .................................................. 39
Amino-dPEG®12-methyl ester Prep KIT .......................... 37
Amino-dPEG®12-ODMT.................................................. 99
Amino-dPEG®12-t-boc-hydrazide .................................... 69
Amino-dPEG®12-t-butyl ester .......................................... 36
Amino-dPEG®₁₂-Tris (dPEG®₁₂-Tris (m-dPEG®₁₁)₃)₃ .. 10
Amino-dPEG®₁₂-Tris(-dPEG®₂₄-acid)₃.......................... 10
Amino-dPEG®₁₂-Tris(m-dPEG®₂₄)₃............................... 10
Amino-dPEG®24-acid ....................................................... 22
Amino-dPEG®24-methyl ester Prep KIT .......................... 37
Amino-dPEG®₂₄-Tris (-dPEG®₂₄-Tris (m-dPEG®₂₄)₃)₃ . 10
Amino-dPEG®2-t-butyl ester ........................................... 36
Amino-dPEG®36-acid ....................................................... 22
Amino-dPEG®4-(m-dPEG®12)3 .......................................... 23
Amino-dPEG®4-(m-dPEG®24)3 .......................................... 23
Amino-dPEG®4-(m-dPEG®4)3 ........................................... 23
Amino-dPEG®4-(m-dPEG®8)3 ........................................... 23
Amino-dPEG®4-acid......................................................... 21
Amino-dPEG®4-alcohol ................................................... 39
Amino-dPEG®4-methyl ester Prep KIT............................ 37
Amino-dPEG®4-t-boc-hydrazide ..................................... 69
Amino-dPEG®6-acid......................................................... 21
Amino-dPEG®8-acid......................................................... 21
Amino-dPEG®8-alcohol ................................................... 39
Amino-dPEG®8-t-boc-hydrazide ..................................... 69
Aminooxy-dPEG®12-amido-dPEG®12-(m-dPEG®11) 3 ....... 24
Azido-dPEG®11-amine.................................................58, 61
Azido-dPEG®12-acid......................................................... 57
Azido-dPEG®12-alcohol.................................................... 40
Azido-dPEG®12-NHS ester............................................... 56
Azido-dPEG®23-amine.................................................58, 61
Azido-dPEG®24-acid......................................................... 57
Azido-dPEG®35-amine.................................................58, 61
Azido-dPEG®3-amine..................................................58, 61
Azido-dPEG®4-acid .......................................................... 57
Azido-dPEG®4-alcohol..................................................... 40
Azido-dPEG®4-NHS ester ................................................ 56
Azido-dPEG®7-amine..................................................58, 61
Azido-dPEG®8-acid ...........................................................57
Azido-dPEG®8-alcohol......................................................40
Azido-dPEG®8-NHS ester.................................................56
B
Bioconjugate Techniques ..................................................5
Biotin-dPEG®11-azide........................................................83
Biotin-dPEG®11-Lipoamide...............................................32
Biotin-dPEG®11-MAL.........................................................80
Biotin-dPEG®11-NH2 ..........................................................77
Biotin-dPEG®11-oxyamine. HCl ........................................78
Biotin-dPEG®12-TFP ester.................................................73
Biotin-dPEG®23-azide........................................................83
Biotin-dPEG®23-MAL.........................................................80
Biotin-dPEG®23-NH2 ..........................................................77
Biotin-dPEG®24-TFP ester.................................................73
Biotin-dPEG®3- Lipoamide ...............................................32
Biotin-dPEG®3-benzophenone ........................................81
Biotin-dPEG®3-cyanocobalamin ................................84, 85
Biotin-dPEG®3-MAL ..........................................................80
Biotin-dPEG®3-NH3+TFA¯..................................................77
Biotin-dPEG®3-oxyamine. HCl .........................................78
Biotin-dPEG®3-TFPA.........................................................81
Biotin-dPEG®4-hydrazide .................................................76
Biotin-dPEG®4-SS-NH-dPEG®₃-ONH₂.............................79
Biotin-dPEG®4-TFP ester ..................................................73
Biotin-dPEG®7-azide .........................................................83
Biotin-dPEG®7-NH2 ...........................................................77
Biotin-dPEG23-Lipoamide.................................................32
Biotinoyl-2-Aminobutyric acid .........................................82
Biotinoylsarcosine ............................................................82
Bis-dPEG®13-acid ..............................................................55
Bis-dPEG®13-NHS ester ....................................................52
Bis-dPEG®13-PFP ester......................................................54
Bis-dPEG®17-acid ..............................................................55
Bis-dPEG®21-acid ..............................................................55
Bis-dPEG®25-acid ..............................................................55
Bis-dPEG®25-TFP ester......................................................54
Bis-dPEG®29-acid ..............................................................55
Bis-dPEG®2-acid................................................................55
Bis-dPEG®2-NHS ester......................................................51
Bis-dPEG®2-PFP ester .......................................................53
Bis-dPEG®3-acid................................................................55
Bis-dPEG®3-biotin .............................................................84
Bis-dPEG®4-acid................................................................55
Bis-dPEG®5, half benzyl half NHS ester ...........................64
Bis-dPEG®5-acid................................................................55
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103
Bis-dPEG®5-PFP ester ...................................................... 53
Bis-dPEG®7-acid............................................................... 55
Bis-dPEG®7-NHS ester ................................................... 51
Bis-dPEG®9-acid............................................................... 55
Bis-dPEG®9-NHS ester..................................................... 52
Bis-MAL-dPEG®11 ............................................................. 60
Bis-MAL-dPEG®3 .............................................................. 60
Bis-Maleimide amine, TFA salt ....................................... 66
Bis-MAL-Lysine-dPEG®4- dPEG®12-Tris(-dPEG®₂₄-acid)₃
...................................................................................... 11
Bis-MAL-Lysine-dPEG®4-acid .......................................... 67
Bis-MAL-Lysine-dPEG®4-dPEG®12-Tris(m-dPEG®₂₄)₃.. 11
Bis-MAL-Lysine-dPEG®4-TFP ester ................................. 68
C
Carboxy Fluorescein-dPEG 12-NHS ester ...................... 88
Carboxyl-dPEG®4-(m-dPEG®11)3 ...................................... 16
Carboxyl-dPEG®4-(m-dPEG®4)3 ....................................... 16
Carboxyl-dPEG®4-(m-dPEG®8)3 ....................................... 16
CBZ-N-amido-dPEG®12-acid ........................................... 96
CBZ-N-amido-dPEG®3-amine ......................................... 62
CBZ-N-amido-dPEG®4-acid ............................................ 96
®
Fmoc-N-amido-dPEG®2-acid ...........................................89
Fmoc-N-amido-dPEG®36-acid ..........................................90
Fmoc-N-amido-dPEG®4-NHS ester .................................90
Fmoc-N-amido-dPEG®4-t-boc-hydrazide........................70
Fmoc-N-amido-dPEG®8-NHS ester .................................90
Fmoc-N-Lys-(dPEG®12-biotin)-OH-(acid) .........................91
Fmoc-N-Lys-(dPEG®4-biotin)-OH-(acid) ..........................91
H
Hydroxy-dPEG 12-t-butyl ester ........................................38
Hydroxy-dPEG®24-t-butyl ester ........................................38
Hydroxy-dPEG®4-t-butyl ester..........................................38
®
L
Lipoamido-dPEG 12- TFP ester........................................30
Lipoamido-dPEG®12-acid .................................................31
Lipoamido-dPEG®24- TFP ester........................................30
Lipoamido-dPEG®24-acid .................................................31
Lipoamido-dPEG®4-acid...................................................31
Lipoamido-dPEG®4-TFP ester..........................................30
Lipoamido-dPEG®8- TFP ester.........................................30
Lipoamido-dPEG®8-acid...................................................31
Lissamine Rhodamine B sulfonamide-dPEG®4-acid .......87
®
D
Diamido-dPEG 11-diamine.............................................. 61
DNP-dPEG®12-acid........................................................... 88
DNP-dPEG®12-NHS ester ................................................ 87
DNP-dPEG®4-acid............................................................ 88
DNP-dPEG®4-NHS ester.................................................. 87
dPEG®12-biotin acid ......................................................... 72
dPEG®12-diol .................................................................... 41
dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester)................ 34
dPEG®12-SATA acid (S-acetyl-dPEG®12-acid).................. 35
dPEG®24-biotin acid ......................................................... 72
dPEG®24-SATA (S-acetyl-dPEG®24-NHS ester)................ 34
dPEG®24-SATA acid (S-acetyl-dPEG®24-acid).................. 35
dPEG®48-biotin acid ......................................................... 72
dPEG®4-biotin acid .......................................................... 72
dPEG®4-SATA (S-acetyl-dPEG®4-NHS ester) .................. 34
dPEG®4-SATA acid (S-acetyl-dPEG®4-acid) .................... 35
dPEG®8-SATA (S-acetyl-dPEG®8-NHS ester) .................. 34
dPEG®8-SATA acid (S-acetyl-dPEG®8-acid) .................... 35
M
®
F
Fmoc-amidooxy-dPEG®12 acid........................................ 93
Fmoc-N-amido-dPEG®12-acid ......................................... 90
Fmoc-N-amido-dPEG®12-NHS ester ............................... 90
Fmoc-N-amido-dPEG®24-acid ......................................... 90
MAL-dPEG®12-acid............................................................46
MAL-dPEG®12-DSPE ...........................................................7
MAL-dPEG®12-NHS ester .................................................45
MAL-dPEG®12-t-boc-hydrazide ........................................47
MAL-dPEG®₁₂-Tris (dPEG®₁₂-Tris (m-dPEG®₁₁)₃)₃ ........9
MAL-dPEG®₁₂-Tris(-dPEG®₂₄-acid)₃................................9
MAL-dPEG®₁₂-Tris(m-dPEG®₂₄)₃.....................................9
MAL-dPEG®24-acid............................................................46
MAL-dPEG®24-NHS ester .................................................45
MAL-dPEG®₂₄-Tris (-dPEG®₂₄-Tris (m-dPEG®₂₄)₃)₃ .......9
MAL-dPEG®2-acid.............................................................46
MAL-dPEG®2-NHS ester...................................................45
MAL-dPEG®3-Lipoamide..................................................32
MAL-dPEG®4-(m-dPEG®11)3 ..............................................26
MAL-dPEG®4-(m-dPEG®12)3 ..............................................26
MAL-dPEG®4-(m-dPEG®24)3 ..............................................26
MAL-dPEG®4-(m-dPEG®4)3 ...............................................26
MAL-dPEG®4-(m-dPEG®8)3 ...............................................26
MAL-dPEG®4-acid.............................................................46
MAL-dPEG®4-t-boc-hydrazide .........................................47
MAL-dPEG®6-acid.............................................................46
MAL-dPEG®8-acid.............................................................46
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MAL-dPEG®8-NHS ester.................................................. 45
MAL-dPEG®8-t-boc-hydrazide ........................................ 47
m-dPEG®11-alcohol .......................................................... 17
m-dPEG®11-NHS carbonate ............................................ 18
m-dPEG®12-acid ............................................................... 14
m-dPEG®12-amido-dPEG®12-acid .................................... 13
m-dPEG®12-amine ............................................................ 20
m-dPEG®12-Azide (Azido-m-dPEG®12)............................. 27
m-dPEG®₁₂-DSPE .............................................................. 6
m-dPEG®12-Lipoamide .................................................... 33
m-dPEG®12-MAL .............................................................. 25
m-dPEG®12-NHS ester ..................................................... 12
m-dPEG®12-Propionaldehyde ......................................... 19
m-dPEG®12-Thiol .............................................................. 29
m-dPEG®15-alcohol .......................................................... 17
m-dPEG®15-amine ............................................................ 20
m-dPEG®19-alcohol .......................................................... 17
m-dPEG®23-alcohol .......................................................... 17
m-dPEG®24 Azide (Azido-m-dPEG®24)............................. 27
m-dPEG®24 Azide (Azido-m-dPEG®36)............................. 27
m-dPEG®24-acid ............................................................... 14
m-dPEG®24-amido-dPEG®24-acid .................................... 13
m-dPEG®₂₄-amido-dPEG®₂₄-DSPE .................................. 6
m-dPEG®24-amido-dPEG®24-TFP ester ........................... 13
m-dPEG®24-amine ............................................................ 20
m-dPEG®24-DSPE ............................................................... 6
m-dPEG®24-Lipoamide .................................................... 33
m-dPEG®24-MAL .............................................................. 25
m-dPEG®24-NHS ester ..................................................... 12
m-dPEG®24-Propionaldehyde ......................................... 19
m-dPEG®2-acid ................................................................ 14
m-dPEG®2-NHS ester ...................................................... 12
m-dPEG®2-tosylate .......................................................... 41
m-dPEG®36-alcohol .......................................................... 17
m-dPEG®36-amine ............................................................ 20
m-dPEG®36-MAL .............................................................. 25
m-dPEG®37-acid ............................................................... 14
m-dPEG®37-NHS ester ..................................................... 12
m-dPEG®3-NHS carbonate.............................................. 18
m-dPEG®48-amine ............................................................ 20
m-dPEG®48-CO(CH2)3-acid .............................................. 14
m-dPEG®48-MAL .............................................................. 25
m-dPEG®48-NH-CO(CH2)3CO-TFP ester ......................... 13
m-dPEG®49-NHS ester ..................................................... 12
m-dPEG®4-acid ................................................................ 14
m-dPEG®4-alcohol ........................................................... 17
m-dPEG®4-amine ............................................................. 20
m-dPEG®4-Azide (Azido-m-dPEG®4)............................... 27
m-dPEG®4-Lipoamide...................................................... 33
m-dPEG®4-MAL................................................................ 25
m-dPEG®4-NHS ester ...................................................... 12
m-dPEG®4-Propionaldehyde........................................... 19
m-dPEG®4-Thiol ............................................................... 29
m-dPEG®4-tosylate .......................................................... 41
m-dPEG®7-alcohol ........................................................... 17
m-dPEG®7-NHS carbonate...............................................18
m-dPEG®7-tosylate ...........................................................41
m-dPEG®8-acid .................................................................14
m-dPEG®8-amine ..............................................................20
m-dPEG®8-Azide (Azido-m-dPEG®8)................................27
m-dPEG®8-DSPE .................................................................6
m-dPEG®8-Lipoamide ......................................................33
m-dPEG®8-MAL.................................................................25
m-dPEG®8-NHS ester .......................................................12
m-dPEG®8-Propionaldehyde............................................19
m-dPEG®8-Thiol ................................................................29
Methoxytrityl-N-dPEG®12-acid .........................................94
Methoxytrityl-N-dPEG®12-TFP ester ................................95
Methoxytrityl-N-dPEG®24-acid .........................................94
Methoxytrityl-N-dPEG®4-acid ..........................................94
Methoxytrityl-N-dPEG®4-TFP ester..................................95
Methoxytrityl-N-dPEG®8-acid ..........................................94
Methoxytrityl-N-dPEG®8-TFP ester..................................95
Methoxytrityl-S-dPEG®12-acid ..........................................97
Methoxytrityl-S-dPEG®4 acid............................................97
Methoxytrityl-S-dPEG®8 acid............................................97
MPS (NHS-3-maleimidopropionate) ...............................65
MPS-Acid ..........................................................................65
MPS-EDA.TFA ..................................................................65
N
NH2-dPEG®4-(m-dPEG®11)3-ester......................................23
NHS -dPEG®4-(m-dPEG®12)3-ester....................................15
NHS-biotin ........................................................................84
NHS-dPEG®12-biotin .........................................................71
NHS-dPEG®24-biotin .........................................................71
NHS-dPEG®4 -biotinidase resistant biotin.......................75
NHS-dPEG®4-(m-dPEG®24)3-ester.....................................15
NHS-dPEG®4-(m-dPEG®4)3-ester......................................15
NHS-dPEG®4-(m-dPEG®8)3-ester......................................15
NHS-dPEG®4-biotin ..........................................................71
NHS-dPEG®4-t-boc-hydrazide .........................................70
NHS-S-S-dPEG®4-biotin ...................................................74
P
Phthalimidooxy-dPEG 12 NHS ester................................44
Phthalimidooxy-dPEG®4 NHS ester.................................44
Propargyl amine ...............................................................59
Propargyl-dPEG®1-NHS ester ..........................................59
®
S
S-acetyl-dPEG®12-alcohol .................................................41
S-acetyl-dPEG®4-alcohol ..................................................41
S-acetyl-dPEG®8-alcohol ..................................................41
SPDP-dPEG®12-acid ..........................................................49
SPDP-dPEG®12-NHS ester ................................................48
SPDP-dPEG®24 -NHS ester ...............................................48
SPDP-dPEG®24-acid ..........................................................49
SPDP-dPEG®36-acid ..........................................................49
SPDP-dPEG®36-NHS ester ................................................48
SPDP-dPEG®4-acid ...........................................................49
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SPDP-dPEG®4-NHS ester ................................................ 48
SPDP-dPEG®8-acid .......................................................... 49
SPDP-dPEG®8-NHS ester ................................................ 48
T
t-boc-N-amido-dPEG®11-amine ...................................... 60
t-boc-N-amido-dPEG®12-acid ......................................... 92
t-boc-N-amido-dPEG®12-alcohol .................................... 39
t-boc-N-amido-dPEG®3-amine ....................................... 60
t-boc-N-amido-dPEG®4-acid........................................... 92
t-boc-N-amido-dPEG®4-alcohol ..................................... 39
t-boc-N-amido-dPEG®8-acid............................................92
t-boc-N-EDA.....................................................................62
TFP-dPEG®12-biotinidase resistant biotin ......................75
TFP-dPEG®13-DSPE.............................................................7
TFP-dPEG®4 -Lys-(dPEG®4-biotin)2 ...................................74
TFP-dPEG®4-(m-dPEG®11)3-ester ......................................15
TFP-dPEG®4-(m-dPEG®24)3-ester ......................................15
TFP-dPEG®4-biotinidase resistant biotin .......................75
Thiol-dPEG®12-acid ...........................................................28
Thiol-dPEG®4-acid ............................................................28
Thiol-dPEG®8-acid ............................................................28
Tris(2-carboxyethyl)phosphine hydrochloride (TCEP) ....50
Print Date Thursday, May 22, 2014
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Product Catalog - Quanta BioDesign

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