BIOSTAT® B The Multi-Talented Bioreactor for Research
Transcription
BIOSTAT® B The Multi-Talented Bioreactor for Research
BIOSTAT ® B The Multi-Talented Bioreactor for Research and Development BIOSTAT® B at a Glance Our BIOSTAT® B is the ideal benchtop bioreactor for your lab. The multi-talented control tower opens up a new world of flexibility for your changing requirements. Use it as single or twin configuration, chose your cultivation chamber from our proven range of options: – Conventional stirred tank glass vessels – Single-use stirred tank vessel Univessel® SU – Wave-mixed Flexsafe RM bags Applications – Process development and optimization – Scale-up and scaledown studies – Seed expansion – Cell bank production – Protein supply Cells – Mammalian – Insect – Microbial – Yeast – Fungi Industries – Biopharmaceuticals – Vaccines – Cell therapies – Industrial biotechnology – Basic research – Education Process Modes – Batch – Fed-batch – Continuous – Perfusion Proven Technology With several thousand installations in over 50 countries, BIOSTAT® B is the most successful benchtop bioreactor in the world. Benefit from our experience and collaboration with customers worldwide. Configurable Design Contact your Sartorius representative and configure your BIOSTAT® B bioreactor solution matching your specific needs. Benefit from our flexible and scalable options. Reliable Quality Every BIOSTAT® B is thoroughly tested before it leaves our production facilities in Germany. Benefit from our global service and application specialist network for professional installation and training. UniVessel® Glass Our proven autoclavable borosilicate glass culture vessel is available in four different volumes: 1 L, 2 L, 5 L and 10 L, for all kinds of cell culture and microbial applications. Benefits −− Classic stirred-tank design simplifies your scale-up and scale-down studies −− Extensive performance and engineering data package available −− Save additional investment and use our special design for small autoclaves Fully interchangable glass and single-use stirred-tank culture vessels. UniVessel® SU Our single-use 2 L stirred tank vessel for cell culture applications combines scalable design with all benefits of disposable solutions. No more worries about challenging timelines, workload or cross-contamination. Get started within minutes. Benefits −− Fully single-use vessel, DO and pH sensors −− Proven, scalable stirred tank design −− Connection kit to upgrade existing bioreactor controllers BIOSTAT® B – The Universal Controller for Your Lab Main Applications −− Mammalian, insect, microbial and plant cell culture −− Process development, optimization, characterization −− Seed and small scale production −− Protein supply Main Applications −− Mammalian, insect and plant cell culture −− Process development, optimization, characterization −− Seed and small scale production −− Production of cell banks Watch Video: www.sartorius.com/ video-biostat-b Main Applications −− Mammalian, insect, plant and low density microbial culture −− Seed and small scale production −− Protein supply −− Stem cell expansion and production RM Rocker Our proven wave-mixed bioreactor consists of a rocker unit with bag holder and pillow-shaped Flexsafe RM single-use bags for culture volumes from 100 mL to 25 L. Use it as basic system or in combination with the BIOSTAT® B control tower and single-use optical pH and DO sensors to enable advanced control strategies for batch, fed-batch and continuous perfusion. Benefits −− Optimized film formula, traceability of raw materials and control of the entire Flexsafe RM bag manufacturing process assure excellent and consistent cell growth of the most sensitive cell lines −− Space-saving, individual control of two RM bags on the same rocker platform −− Easy-to-use rocker with advanced alarms and safety features for reliable cultivation 12” Touch Screen with closed frame; protected against water splashes and dust deposits. Easy-to-use and reliable operation of your BIOSTAT® B due to intuitive design of human-machine interface and advanced touchscreen technology – even while wearing laboratory gloves. New Standards for Interference-Free Measurements All inlets and ports for, e.g. cooling water, process gasses, electricity, ethernet and potential-free alarm contact are located on the rear panel of the control tower. An equipotential bonding conductor shields the bioreactor against electromagnetic current and ensures interference-free measurements during your processes. Control Tower The control tower contains both the aeration, pump and temperature control modules, saving valuable bench space in your lab. BIOSTAT® B Configurable Flexibility Single | Twin Control Tower One BIOSTAT® B control tower can control up to two vessels completely independently to save valuable lab space. Select culture vessel types and volumes from our range of options, e.g. glass vessel, single-use vessel or wave-mixed Flexsafe® RM bags. Fast Load Peristaltic Pumps Insert the tubing in seconds: Open, insert tube, close, done! No more pinched fingers or torn gloves. Up to four internal pumps can be selected per vessel. Choose between speedcontrolled pumps and fixedspeed pumps for feed and corrective agent addition. Connections for Sensors and External Accessories Quick-connect couplings make it easy to attach all cables and supplies to the culture vessels. All connections are clearly marked with the same names used on the rear control tower panel and in the local control software menu for fast, error proof identification. Storage Tray A storage tray for accessories helps you organize your workplace. Aeration Strategies A series of flexible aeration options turns the BIOSTAT® B into a multitalented bioreactor for a wide range of different applications, including high-cell density microbial fermentation requiring considerable amounts of oxygen to high-cell density cell culture applications requiring removal of excessive carbon dioxide. Microbial Applications in Combination with UniVessel® Glass Various controller and hardware configurations enable aeration strategies using air or oxygen or classical O2 enrichment of air. For anaerobic processes, the air inlet can be used for nitrogen. The standard built-in solenoid valves in combination with a flow meter ensure reliable gas supply for simple applications. Optional mass flow controllers provide exact flow rate control of individual gases. In combination with BioPAT® Xgas off-gas analysis, this allows mass balancing consumed and produced gases. Gas Inlet Solenoid Valve MFC* (max. 2) (max. 2) Air Flow Meter Gas Outlet Sparger O2 *MFC = mass flow controller Cell Culture and Multi-Purpose Applications in Combination with UniVessel® Glass and UniVessel® SU Gas Inlet Solenoid Valve MFC * (4 max.) (4 max.) Flow Meter Gas Outlet Overlay Air Sparger O2 N2 CO2 Switching CO2 from sparger to overlay *MFC = mass flow controller Five different gas lines, equipped with solenoid valves and|or up to four optional mass flow controllers and flow meters deliver ultimate flexibility and accuracy. The BIOSTAT® B allows you to optionally switch between sparger and overlay supply of CO2 for pH control. In addition, a constant air | CO2 mixture can be created in the overlay line to reproduce conditions like those prevailing in a CO2 incubator. Cell Culture Applications in Combination with Our Rocking-Motion Bioreactor The wave generated in the RM bags due to the rocking motion ensures effective gas exchange through the gas-liquid interface. Four different gas lines for air, O2, N2 and CO2 are equipped with flow meters and four high-precision mass flow controllers. An integrated pressure sensor continuously measures the pressure inside the bag. To ensure process safety, aeration is switched off when an upper threshold is reached. Gas Inlet MFC* Flow Meter Gas Outlet Overlay Air O2 N2 CO2 *MFC = mass flow controller You can configure your BIOSTAT® B aeration system in a similar way as your BIOSTAT® STR single-use stirred tank bioreactor. Get ready for seamless scale-up and -down, from laboratory scale to large scale single-use production. DCU – Local Control Since we introduced the first DCU-controlled bioreactors back in the late 80’s, we have installed thousands of such bioreactors to date at leading companies in the pharmaceutical and biotech industry worldwide. We have continuously improved our robust, intuitive-use and industry-proven DCU control technology, now available in its fourth generation. It is our standard local control platform for our BIOSTAT® bioreactors, SARTOFLOW® crossflow filtration units and FlexAct® configurable systems available for a large number of unit operations. The intuitive touch screen on the control tower is used to locally operate the BIOSTAT® B: Aeration control Balances and gravimetric flow control Overview of process parameters Pump module Submenus Overview and close-up Culture vessels Status display Automatic Feed Control and Continuous Processing Design your process strategy or select different options. Configure your BIOSTAT® B with gravimetric feed control, gravimetric level control or substrate addition profiles. This enables you to run your BIOSTAT® B in batch, fed-batch, continuous or perfusion mode. Automatic DO Control Besides classic DO cascade control, we have developed the unique advanced DO controller that gives you more flexibility to develop and optimize your DO control strategy. The advanced DO controller supports parallel adjustment of all DO affecting parameter settings like stirrer speed and gas flow rates of air and pure oxygen, automatically and simultaneously to control the DO set point. Optionally, you can keep the total gas flow rate constant and the ratio of pure oxygen in the gas mixture is increased automatically to match the oxygen consumption of the culture. This gives you ultimate flexibility to adapt your aeration strategy to your process requirements. Automatic pH Control Control the pH of your culture by automatic acid and base addition or by CO2 aeration and base addition. If you want to use your BIOSTAT® B for both microbial and cell culture you can configure your bioreactor system with a combined acid control via CO2 aeration and acid addition. CO2 Base Acid BioPAT® MFCS – SCADA Process Control BioPAT® MFCS is a multi-functional supervisory control and data acquisition software, specifically developed for bioprocessing applications in upstream and downstream. Every BIOSTAT® bioreactor comes with basic data recording functionality of our BioPAT® MFCS. Rely on more than 7,000 installations worldwide and over 25 years of experience. – Multi-user network access for up to 16 process units – On-line and off-line sample data management, visualization, evaluation – Remote monitoring, control and alarming BioPAT® MFCS | win In addition to providing a genuine SCADA system for conventional and single-use bioprocess applications, the optional advanced version of BioPAT® MFCS includes a series of add-on modules: – Bioprocess optimization with Design of Experiments module (DoE) – Automation with recipes according to ANSI | ISA-88.01 – 21 CFR, Part 11 compatibility – Secure integration into company networks – Flexible device connection facility through OPC – Expanded data recording and data archiving capabilities – Alarm recording and transmission to multimedia devices Our Mission Is Your Productivity We are well aware of how important smooth-running equipment is for effective process development and efficient production. That is why we at Sartorius offer you a broad range of preventive technical service, repair and application specialist support. Our ISO certified quality management system ensures that you receive equipment and services that meet the strictest quality requirements. Become one of our many customers who benefit from our local presence worldwide, highly qualified specialists and well-versed technicians. Services Offered for BIOSTAT® B −− On-site installation and application specialist support, ensuring that your equipment is perfectly up and unning right from the start −− Factory acceptance and site-acceptance testing −− On-site preventive maintenance and repair −− Consumable and spare part kits Technical Specifications BIOSTAT® B Control Tower Weight Single | Twin ~ 40 | 55 kg (88 | 121 lbs.) Control Tower Dimensions (W + H + D) Single | Twin 410 + 810 + 520 mm (16“ + 32“ + 20“) Utility Connections Power supply – 230 V (± 10%), 50 Hz, max. power consumption 10 A – 120 V (± 10%), 60 Hz, max. power consumption 12 A – Potential equalisation International protection rating IP21 Gases – Gas supply pressure, 1.5 barg – Dry, oil and dust-free – Hose barb for tubing, external dia. = 6 mm Water – Water supply pressure, 2 – 8 barg – Flow rate up to 20 lpm – Temperature min. = 4°C – Discharge pressure-less – Hose barb for tubing, external dia. = 10 mm – Degree of hardness: 12 dH max. Control Tower Housing Stainless steel, AISI 304 Display Touch screen, 12”, glass, capacitive Resolution 125 dpi SCADA communication Industrial Ethernet Potential-free (common) alarm contact • Safety valve gas pressure 1 bar (14.5 psi) for UniVessel® Glass and SU | 100 mbar for RM Water inlet pressure reduction 1.5 bar (22 psi), integrated pressure control ® Motor Drive (Univessel Glass | SU) Maintenance-free, quiet direct drive Power: 200 W Maintenance-free top drive with magnetic motor coupling Power: 200 W Rotation speed motor, direct coupling 1L: 20 – 2,000 rpm 2L: 20 – 2,000 rpm 5L: 20 – 1,500 rpm 10L: 20 – 800 rpm 2L SU: 20 – 400 rpm Rocker Platform Power supply – 230 V (± 10%), 50 Hz, power consumption 10 A – 120 V (± 10%), 60 Hz, power consumption 12 A Power consumption 600 W International protection rating IP23 Rocking speed 8 – 42 ± 1 (r/min) Rocking angle 4 –10 ± 0.3 (°) Process Control | Sensors UniVessel® Glass UniVessel® SU Rocking Motion Pt100 | 0–150°C (temperature control 0-80°C) | 0.1°C • • • Dissolved oxygen, reusable Polarographic or optical | 0–100 % | 0.1 % • • Dissolved oxygen, single-use Range: 0 –100 % Precision: 0.1% pH, reusable Combined measuring electrode Range: 2–12 pH Precision: 0.01 pH pH, single-use Range: 6.5 - 8.5 pH Precision: 0.1 pH Foam control Electrical conductive sensor, stainless steel, ceramic insulated • Level Electrical conductive sensor, stainless steel, ceramic insulated • Turbidity 1-channel NIR absorption sensor | 0–6 AU | 0,01 AU • Redox Combined measurement with pH sensor | -1,000 – 1,000 mV | 1 mV • • Balance substrate 7 kg max. | 1 g 60 kg max. | 2 g 300 kg max. | 100 g • • Balance culture vessel 60 kg max. | 2 g • • RM load cells 30 kg max. | 10 g Weight: 9 kg Dimensions: 609 | 536 | 60-68 mm 100–240 V VAC | 24 VDC | 15 W External signal input 0–10 V or 4-20 mA UniVessel® Glass | SU: 4 max. Rocker: 2 max. Sensor | Measurement Range | Display Accuracy Temperature • • • • • • • • • • • Aeration Module Outlet to culture vessel | bag ® UniVessel Glass MO (Microbial) Hose coupling d external = 6 mm Two-gas mixing with sparger outlet AIR with O2 Enrichment or Gas Flow Ratio mixing along with anaerobic fermentation; for further information, please see page on “aeration strategies” Max. total flow Up to 20 l/min total volume flow Flow rate controllers 2 Flow rate controller range Various models available: 0.1-20 liters per min. [lpm] (sparger) Accuracy of flow rate controllers ± 5 % full scale Mass flow controllers (optional) 2 max. Flow rates of mass flow controllers Various models available: 0.03-20 lpm (sparger) Accuracy of mass flow controllers ± 1 % full scale ® UniVessel Glass CC (Cell Culture) | UniVessel® SU Four-gas mxing with sparger and headspace outlet Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies” Max. total flow Up to 13 l/min total volume flow Number of flow rate controllers 5 Flow rate controller range Various models available: 3.3 ccm – 1.6 lpm (sparger) 0.16 lpm – 13 lpm (headspace) Accuracy of flow rate controllers ± 5 % FS Mass flow controllers (optional) 4 max. Flow rates of mass flow controllers Various models available: 1 ccm – 1.5 lpm (sparger) 0.03 lpm – 10 lpm (headspace) Precision of mass flow controllers ± 1 % FS UniVessel® Glass, Dual Use Four-gas mixing with sparger and headspace outlet Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies” Max. total flow Up to 20 l/min total volume flow Flow rate controllers 5 Flow rate controller range Various models available: 3.3 ccm – 20 lpm (sparger) 50 ccm – 20 lpm (headspace) Accuracy of flow rate controllers ± 5% full scale Mass flow controllers (optional) 4 max. Flow rates of mass flow controllers Various models available: 0.6 ccm – 20 lpm (sparger) 10 ccm – 20 lpm (headspace) Precision of mass flow controllers ± 1 % FS Rocker Four-gas mixing with sparger and headspace outlet Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies” Max. total flow Up to 10 l/min total volume flow Max. CO2 flow One bag: 1 + 1 lpm Twin bag: 2 + 0.5 lpm CO2 concentration controller 0.8 % – 15% | ± 5% Flow rate controllers 4 Flow rate controller range Various models available: 16 ccm – 36 lpm (headspace) Accuracy of flow rate controllers ± 5% full scale Mass flow controllers (optional) 2 max. Flow rates of mass flow controllers Various models available: 3 ccm – 3 lpm (headspace) Precision of mass flow controllers ± 1% full scale Pump Module Built-in Pumps Fixed speed (on | off controlled) Watson Marlow 114, Fast Load pump head – Speed 5 rpm Flow rate (tubing wall thickness 1.6 mm) ID: 0.5 mm: 0–0.1 ml/min ID: 0.8 mm: 0.05–2.4 ml/min ID: 1.6 mm: 0.01–0.7 ml/min ID: 2.4 mm: 0.03–1.5 ml/min ID: 3.2 mm: 0.05–2.4 ml/min ID: 4.8 mm: 0.09–4.3 ml/min – Speed 44 rpm Flow rate (tubing wall thickness 1.6 mm) ID: 0.5 mm: 0.02–0.9 ml/min ID: 0.8 mm: 0.04–1.8 ml/min ID: 1.6 mm: 0.12–6.2 ml/min ID: 2.4 mm: 0.26–12.8 ml/min ID: 3.2 mm: 0.41–20.7 ml/min ID: 4.8 mm: 0.75–37.4 ml/min Speed-controlled Watson Marlow 114, Fast Load pump head – Speed 0.15–5 rpm Flow rate (tubing wall thickness 1.6 mm) ID: 0.5 mm: 0–0.1 ml/min ID: 0.8 mm: 0.01–0.2 ml/min ID: 1.6 mm: 0.02–0.7 ml/min ID: 2.4 mm: 0.04–1.5 ml/min ID: 3.2 mm: 0.07–2.4 ml/min ID: 4.8 mm: 0.13–4.3 ml/min – Speed 5–150 rpm Flow rate (tubing wall thickness 1.6 mm) ID: 0.5 mm: 0.1–3 ml/min ID: 0.8 mm: 0.2–6 ml/min ID: 1.6 mm: 0.7–21 ml/min ID: 2.4 mm: 1.45–43.5 ml/min ID: 3.2 mm: 2.35–70.5 ml/min ID: 4.8 mm: 4.25–127.5 ml/min External Pumps Speed-controlled Watson Marlow 120, Fast Load pump head, up to 200 rpm Temperature Control Module Heating and Cooling Heating Only For UniVessel® Glass Single-wall Culture Vessels Electrical heating system and automatic cooling water valve; connection to heating blanket and cooling finger – Temperature control of 8°C above cooling-water inlet temperature up to 60°C – Heating blanket capacities 1 L | 2 L | 5 L | 10 L: 100 | 170 | 400 | 780 W – For UniVessel® Glass Double-wall (Jacketed) Culture Vessels Open thermostat system with recirculation pump and automatic cooling water valve – Temperature control of 8°C above cooling-water inlet temperature of up to 80°C – Heating capacity: 600 W – For UniVessel® SU Single-use Culture Vessels Open thermostat system with recirculation pump and automatic cooling water valve; connection to heating | cooling jacket Electrical heating blanket Temperature control up to 50°C Temperature control up to 50°C Heating capacity 2L : 200 W For BIOSTAT® RM Rocking-motion Bioreactor Open thermostat system with recirculation pump and automatic cooling water valve Electrical heating plates Temperature control of 8°C above cooling-water inlet temperature of up to 40°C Temperature control from room temperature up to 40°C Heating capacity: 600 W Heating plates: 2 + 140 W Culture Vessel UniVessel® Glass Autoclavable Single-wall or Double-wall (Jacketed) Glass Vessel 1L Material Borosilicate glass, stainless steel AISI 316L, EPDM Sizes [L] 1 2 5 10 Total volume [L] 1.6 3 6.6 13 Working volume [L] 0.4 –1 0.6 – 2 0.6 – 5 1.5 | 5 –10 Top port 19 mm | 12 mm | 6 mm 3 | 2 | 6 3 | 2 | 9 3 | 3 | 8 5 | 2 | 9 UniVessel®, Single-wall 1L 2L 5L 10 L Weight1 [kg] 6 7 12 19 Space requirements in autoclave [W + H + D mm] 200 + 540 + 270 230 + 600 + 300 260 + 730 + 340 330 + 860 + 420 480 + 410 + 300 530 + 510 + 410 540 + 630 + 420 Space requirements in autoclave, reduced2 [W + H + D mm] ® 2 5L 10 L UniVessel , Double-wall 1L 2L 5L 10 L Weight1 [kg] 7 8 14 23 Space requirements in autoclave [W + H + D mm] 330 + 540 + 270 380 + 600 + 300 410 + 730 + 340 450 + 860 + 420 480 + 410 + 300 530 + 510 + 410 540 + 630 + 420 Space requirements in autoclave, reduced2 [W + H + D mm] 1 2L With tripod and head plate, without medium Adapter for exhaust cooler to reduce height in the autoclave optionally available Culture Vessel UniVessel® SU Single-use vessel made of pre-sterilized polycarbonate for cell culture applications Total volume [L] 2.6 Working volume [L] 0.6–2 Max. temperature 50 °C Operating pressure < 0.5 barg Basic Configurations The BIOSTAT® B is a highly flexible and modular system that can be individually adapted to the requirements of your application. Below you will find an overview of the basic equipment which you can extend with diverse options. Please contact your Sartorius Stedim Field Representative or Application Specialist for additional information. Microbial Packages for UniVessel® Glass Volume Single Twin Digital controller, color display with touch screen Control temperature, pH, DO, stirrer speed Maintenance-free, quiet motor Storage tray for accessories Aeration module with 2 solenoid valves 2 flow rate controllers for manual flow rate control (AIR | N2, O2) Software configured for microbial applications 4-stage DO cascade BioPAT® MFCS software for data acquisition 2 integrated pumps for pH control (acid | base) Temperature control module for double-wall vessels 2 external signals 0 –10 V Standard test and documentation Installation set for the gas and water connections Power cable Double-wall culture vessel Stirrer shaft with single-mechanical seal and direct coupling 2 addition bottles for correction agents Exhaust cooler Aeration filters Rushton impellers Ring sparger 4-way addition port Inoculation port Harvest pipe, height-adjustable Manual sampler Tool set for disassembly of vessel Pt100 temperature sensor pH sensor DO sensor, amperometric Cell Culture Packages for UniVessel® Glass Volume Single Twin Digital controller, color display with touch screen Control temperature, pH, DO, stirrer speed Maintenance-free, quiet motor Storage tray for accessories Aeration module with 4 solenoid valves 5 flow rate controllers for manual flow rate control (AIR Overlay, AIR sparger, N2, O2, CO2) Software configured for cell culture applications 4-stage DO cascade BioPAT® MFCS software for data acquisition 1 integrated pump for pH control (base) Temperature control module for single-wall vessels 2 external signals 0 –10 V Standard test and documentation Installation set for the gas and water connections Power cable Single-wall culture vessel with tripod Heating blanket 120 | 230 V Stirrer shaft with single mechanical seal and direct coupling 1 addition bottle for correction agent Exhaust cooler Aeration filters 3-blade segment impeller Microsparger 4-way addition port Harvest pipe, height-adjustable Manual sampler Tool set for vessel dismantling Pt100 temperature sensor pH sensor DO sensor, amperometric Options Control System Advanced DO controller Flexible switching CO2 from sparger to headspace Software for dual use MO | CC Mass flow controller Antifoam control via sensor Mechanical foam destroyer (MO applications) Level control via sensor Weight measurement substrates | culture vessel Gravimetric feed | level control Substrate addition via time profile Redox (ORP) measurement Turbidity measurement BioPAT® Xgas O2 | CO2 off-gas analysis System IQ | OQ BioPAT® MFCS SCADA system UniVessel® Glass Double-wall culture vessel Magnetic coupling for drive motor STT connectors for safe inoculation and media transfer Cooling finger (single-wall culture vessels) Spin filter for perfusion mode Aeration basket for organisms sensitive to shear stress Rushton impellers | 3-blade segment impellers Baffles Bottle holder Adapter for height reduction of exhaust cooler for the autoclave Inoculation port 3-way addition port Universal adapter ID 3.2 mm Harvest pipe bent for complete draining Port adapter 19 mm – 12 mm Set of consumables Sales Salesand andService ServiceContacts Contacts Sales les Sales and Sales and and Service Service Service and Service Contacts Contacts Contacts Contacts For further contacts, visit www.sartorius-stedim.com For further contacts, visit www.sartorius-stedim.com or For urther further further contacts, For contacts, contacts, further visitvisit contacts, visit www.sartorius-stedim.com www.sartorius-stedim.com www.sartorius-stedim.com visit www.sartorius-stedim.com Europe Europe Europe Europe ropeEurope America America America America America America Netherlands Netherlands Germany USA India Germany USA India Netherlands Netherlands Sartorius B.V. SartoriusStedim StedimNetherlands Netherlands B.V. Netherlands Netherlands Sartorius Sartorius Inc. SartoriusStedim StedimBiotech BiotechGmbH GmbH SartoriusStedim StedimNorth NorthAmerica America Inc. IndiaSartorius SartoriusStedim StedimIndia IndiaPvt. Pvt.Ltd. Ltd many ermany Germany Germany USA USA USA USA India India India Sartorius Sartorius Stedim Netherlands Stedim Netherlands B.V. B.V. Sartorius Sartorius Stedim Stedim Netherlands Netherlands B.V. B.V. orius artorius Sartorius Stedim Stedim Sartorius Stedim Biotech Biotech Biotech Stedim GmbH GmbH Biotech GmbH GmbH Sartorius Sartorius Stedim Stedim Sartorius Stedim North North Stedim America America America North Inc. Inc. America Inc. Inc. Sartorius Sartorius Stedim Stedim Sartorius Stedim India India India Stedim Pvt.Pvt. Ltd. Pvt.India Ltd. Ltd. Pvt. Ltd. August-Spindler-Strasse 1111 5 5North Orville Drive, Suite 200 #69/2-69/3, NH 48, Jakkasandra August-Spindler-Strasse Orville Drive, Suite 200 Sartorius #69/2-69/3, NH 48, Jakkasand Phone Phone+31.30.60.25.080 +31.30.60.25.080 Sartorius ust-Spindler-Strasse ugust-Spindler-Strasse August-Spindler-Strasse August-Spindler-Strasse 11 11 11 11 5 Orville 5 5 Orville Orville Drive, Drive, 5 Drive, Orville Suite Suite Suite 200 Drive, 200 200 Suite 200 #69/2-69/3, #69/2-69/3, #69/2-69/3, NH #69/2-69/3, NH 48, NH 48, Jakkasandra 48, Jakkasandra Jakkasandra NH 48, Jakkasandra 37079 Bohemia, Nelamangala 37079Goettingen Goettingen Bohemia,NY NY11716 11716 NelamangalaTqTq Phone +31.30.60.25.080 Phone +31.30.60.25.080 Phone Phone +31.30.60.25.080 +31.30.60.25.080 Fax Fax+31.30.60.25.099 +31.30.60.25.099 79 7079 37079 Goettingen Goettingen Goettingen 37079 Goettingen Bohemia, Bohemia, Bohemia, NYBohemia, NY 11716 NY11716 11716 NY 11716 Nelamangala Nelamangala Nelamangala Nelamangala Tq Tq Tq Tq 562 562123 123Bangalore, Bangalore,India India Fax+31.30.60.25.099 +31.30.60.25.099 Fax +31.30.60.25.099 FaxFax +31.30.60.25.099 Phone Phone+49.551.308.0 +49.551.308.0 Toll-Free+1.800.368.7178 +1.800.368.7178 562562 123 562123 Bangalore, 123Bangalore, 562 Bangalore, 123India Bangalore, India India India [email protected] [email protected] Toll-Free ne hone Phone +49.551.308.0 +49.551.308.0 +49.551.308.0 Phone +49.551.308.0 Toll-Free Toll-Free Toll-Free +1.800.368.7178 +1.800.368.7178 Toll-Free +1.800.368.7178 +1.800.368.7178 Fax Fax Phone Fax+49.551.308.3289 +49.551.308.3289 Fax+1.631.254.4253 +1.631.254.4253 Phone+91.80.4350.5250 +91.80.4350.5250 [email protected] [email protected] [email protected] [email protected] +49.551.308.3289 ax Fax+49.551.308.3289 +49.551.308.3289 Fax +49.551.308.3289 FaxFax +1.631.254.4253 Fax+1.631.254.4253 +1.631.254.4253 Fax +1.631.254.4253 Phone Phone Phone +91.80.4350.5250 +91.80.4350.5250 +91.80.4350.5250 Phone +91.80.4350.5250 Fax +91.80.4350.5253 Fax +91.80.4350.5253 FaxFax +91.80.4350.5253 Fax+91.80.4350.5253 +91.80.4350.5253 Fax +91.80.4350.5253 Poland Poland Sartorius Argentina SartoriusStedim StedimSystems SystemsGmbH GmbH Argentina Poland Poland Poland Poland Sartorius Stedim Poland Sp. z o.o. Sartorius Stedim Poland Sp. z o.o. orius artorius Sartorius Stedim Stedim Sartorius Stedim Systems Systems Systems Stedim GmbH GmbH Systems GmbH5 5–GmbH Argentina Argentina Argentina Argentina Robert-Bosch-Strasse Sartorius Japan Robert-Bosch-Strasse –7 7 Sartorius SartoriusArgentina ArgentinaS.A. S.A. Japan Sartorius Sartorius Stedim Stedim Sartorius Stedim Poland Poland Poland Stedim Sp.Sp. z70 Sp. Poland o.o. z zo.o. o.o.Sp. z o.o. ul. ul.Wrzesinska Wrzesinska 70 ert-Bosch-Strasse obert-Bosch-Strasse Robert-Bosch-Strasse Robert-Bosch-Strasse 5 – 57 –5 7– 7 5 – 7 Sartorius Sartorius Sartorius Argentina Argentina Sartorius Argentina S.A. Argentina S.A. S.A. 4251 S.A. Japan Japan Japan Japan 34302 Int. Sartorius 34302Guxhagen Guxhagen Int.A. A.Ávalos Ávalos 4251 SartoriusStedim StedimJapan JapanK.K. K.K. ul. ul. Wrzesinska ul.Wrzesinska Wrzesinska ul.62-025 70 Wrzesinska 7070 Kostrzyn 70 62-025 Kostrzyn 02 4302 34302 Guxhagen Guxhagen Guxhagen 34302 Guxhagen Int. Int. A. Int. Ávalos A. A. Ávalos Ávalos Int. 4251 A. 4251 4251 Ávalos 4251 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Japan Japan Japan Stedim K.K. K.K. K.K. Japan K.K. North B1605ECS 4th Fl., Daiwa Shinagawa B1605ECSMunro Munro 4th Fl., Daiwa Shinagawa Nort 62-025 62-025 62-025 Kostrzyn Kostrzyn Kostrzyn 62-025 Kostrzyn Phone Phone+49.5665.407.0 +49.5665.407.0 B1605ECS B1605ECS B1605ECS Munro B1605ECS Munro Munro Munro 4th 4th Fl., 4th Fl., Daiwa Fl., Daiwa Daiwa 4th Shinagawa Fl., Shinagawa Shinagawa Daiwa North Shinagawa North North Bldg. Bldg. Bldg. North Bldg Phone +48.61.647.38.40 Phone +48.61.647.38.40 Buenos 8-11, BuenosAires Aires 8-11,Kita-Shinagawa Kita-Shinagawa1-chome 1-chom ne hone Phone +49.5665.407.0 +49.5665.407.0 +49.5665.407.0 Phone +49.5665.407.0 Fax Fax+49.5665.407.2200 +49.5665.407.2200 Phone Phone Phone +48.61.647.38.40 +48.61.647.38.40 +48.61.647.38.40 Phone +48.61.647.38.40 Buenos Buenos Buenos Aires Aires Aires Buenos Aires 8-11, 8-11, 8-11, Kita-Shinagawa Kita-Shinagawa Kita-Shinagawa 8-11,Shinagawa-ku, Kita-Shinagawa 1-chome 1-chome 1-chome 1-chome Fax +48.61.879.25.04 Fax +48.61.879.25.04 Shinagawa-ku,Tokyo, Tokyo,140-0001 140-000 +49.5665.407.2200 ax Fax+49.5665.407.2200 +49.5665.407.2200 Fax +49.5665.407.2200 Phone Phone+54.11.4721.0505 +54.11.4721.0505 Shinagawa-ku, FaxFax +48.61.879.25.04 Fax+48.61.879.25.04 +48.61.879.25.04 Fax +48.61.879.25.04 Shinagawa-ku, Shinagawa-ku, Shinagawa-ku, Tokyo, Tokyo, Tokyo, 140-0001 140-0001 140-0001 Tokyo, Japan 140-0001 Japan Japan Japa Phone Phone Phone +54.11.4721.0505 +54.11.4721.0505 +54.11.4721.0505 Phone +54.11.4721.0505 Fax Phone Fax+54.11.4762.2333 +54.11.4762.2333 Phone+81.3.4331.4300 +81.3.4331.4300 France France FaxFax +54.11.4762.2333 Fax+54.11.4762.2333 +54.11.4762.2333 Fax +54.11.4762.2333 Phone Phone Phone +81.3.4331.4300 +81.3.4331.4300 +81.3.4331.4300 Phone +81.3.4331.4300 Russian Federation Russian Federation Fax Fax+81.3.4331.4301 +81.3.4331.4301 rance France ce France Russian Russian Federation Federation Russian Federation Federation Sartorius SartoriusStedim StedimFMT FMTS.A.S. S.A.S. Russian FaxFax +81.3.4331.4301 Fax+81.3.4331.4301 +81.3.4331.4301 Fax +81.3.4331.4301 LLC ICR”and LLC“Sartorius “Sartorius ICR”andLLC LLC“Biohit” “Biohit” orius artorius Sartorius Stedim Stedim Sartorius Stedim FMTFMT FMT S.A.S. Stedim S.A.S. S.A.S. FMT S.A.S. LLCLLC “Sartorius LLC“Sartorius “Sartorius LLC ICR”and “Sartorius ICR”and ICR”and LLCLLC “Biohit” ICR”and LLC“Biohit” “Biohit” LLC “Biohit” ZIZIdes Brazil desPaluds Paluds Brazil Uralskaya str. 4, Lit. B Uralskaya str. 4, Lit. B es IZIdes Paluds desPaluds Paluds ZI des Paluds Brazil Brazil Brazil Brazil Uralskaya Uralskaya Uralskaya str.Uralskaya str. 4,str. Lit. 4,4,Lit. BLit.str. B B 4, Lit. B Avenue de Jouques – –CSCS91051 Sartorius do Malaysia Avenue de Jouques 91051 Sartorius doBrasil BrasilLtda Ltda Malaysia Malaysia 199155, Saint-Petersburg 199155, Saint-Petersburg Sartorius nue venue Avenue de Jouques deAvenue deJouques Jouques –de CS –Jouques –CS 91051 CS91051 91051 – CS 91051 199155, Sartorius Sartorius do do Sartorius Brasil doBrasil Brasil Ltda Ltda do Ltda Brasil Ltda Malaysia Malaysia Malaysia 199155, 199155, Saint-Petersburg Saint-Petersburg 199155, Saint-Petersburg Saint-Petersburg 13781 Aubagne Cedex Avenida Senador Vergueiro 2962 Sartorius Stedim Malaysia Sdn. 13781 Aubagne Cedex Avenida Senador Vergueiro 2962 Sartorius Stedim Malaysia Sdn 81 3781 13781 Aubagne Aubagne Aubagne 13781 Cedex Cedex Aubagne Cedex Cedex Avenida Avenida Avenida Senador Senador Avenida Senador Vergueiro Vergueiro Senador Vergueiro 2962 Vergueiro 2962 2962 2962 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Malaysia Malaysia Malaysia Stedim Sdn. Sdn. Malaysia Sdn. Bhd. Bhd. Bhd. Sdn. Bhd. Phone +7.812.327.5.327 Phone +7.812.327.5.327 Bernardo dodoCampo Lot São Bernardo Campo LotLot LotL3-E-3B, L3-E-3B, Enterprise Phone Phone Phone +7.812.327.5.327 +7.812.327.5.327 +7.812.327.5.327 Phone +7.812.327.5.327 SãoSão Bernardo SãoBernardo Bernardo São doSão Bernardo do Campo do Campo Campo do Campo L3-E-3B, LotL3-E-3B, L3-E-3B, Lot Enterprise Enterprise L3-E-3B, Enterprise 4 Enterprise 4 4 Enterprise 4 44 Phone +33.442.845600 Phone+33.442.845600 +33.442.845600 ne hone Phone +33.442.845600 +33.442.845600 +33.442.845600 Phone Fax +7.812.327.5.323 Fax +7.812.327.5.323 - -SPTechnology 09600-000 SP-Brasil BrasilTechnology Technology ParkMalaysia Malaysia FaxFax +7.812.327.5.323 Fax+7.812.327.5.323 +7.812.327.5.323 Fax +7.812.327.5.323 CEPCEP 09600-000 CEP09600-000 09600-000 CEPCEP -CEP 09600-000 SP-09600-000 -SPBrasil SP-Brasil Brasil - SPBrasil Technology Technology Park Technology Park Park Malaysia Malaysia Malaysia Park Park Malaysia Fax +33.442.845619 Fax+33.442.845619 +33.442.845619 +33.442.845619 ax Fax+33.442.845619 +33.442.845619 Fax Bukit Jalil Bukit Bukit JalilJalil Jalil BukitBukit Jalil Jalil Phone +55.11.4362.8900 Phone +55.11.4362.8900 Bukit Phone Phone Phone +55.11.4362.8900 +55.11.4362.8900 +55.11.4362.8900 Phone +55.11.4362.8900 57000 Kuala Lumpur, Malaysia 57000 Kuala Lumpur, Malaysia 57000 57000 57000 Kuala Kuala Kuala 57000 Lumpur, Lumpur, Lumpur, Kuala Malaysia Malaysia Lumpur, Malaysia Malaysia Spain Spain ++55.11.4362.8901 55.11.4362.8901 Spain Spain Spain FaxFax +Fax 55.11.4362.8901 + +55.11.4362.8901 55.11.4362.8901 FaxFax +Fax 55.11.4362.8901 Sartorius Stedim France SAS Sartorius Stedim France SAS Spain orius artorius Sartorius Stedim Stedim Sartorius Stedim France France France Stedim SASSAS SAS France SAS Sartorius Stedim Spain, S.A.U. Sartorius Stedim Spain, S.A.U. Phone +60.3.8996.0622 Phone +60.3.8996.0622 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Spain, Spain, Spain, Stedim S.A.U. S.A.U. S.A.U. Spain, S.A.U. Phone Phone Phone +60.3.8996.0622 +60.3.8996.0622 +60.3.8996.0622 Phone +60.3.8996.0622 ZI des Paluds desPaluds Paluds es IZIdes Paluds desPaluds Paluds ZIZIdes Avda. Avda. delaIndustria, laIndustria, Industria, Fax Fax+60.3.8996.0755 +60.3.8996.0755 Avda. Avda. Avda. de la dede Industria, laAvda. la Industria, Industria, dede 32 la 32 32 323232 FaxFax +60.3.8996.0755 Fax+60.3.8996.0755 +60.3.8996.0755 Fax +60.3.8996.0755 de Jouques 71058 Mexico Avenue de Jouques –CSCS 71058 Mexico nue venue Avenue de Jouques deAvenue Avenue deJouques Jouques –de CS –Jouques –CS 71058 CS71058 71058 ––CS 71058 Mexico Mexico Mexico Mexico Edificio PAYMA Edificio PAYMA Edificio Edificio Edificio PAYMA PAYMA Edificio PAYMA PAYMA 13781 Aubagne Cedex Sartorius dede México S.A. dedeC.V. 13781 Aubagne Cedex Sartorius México S.A. C.V. 81 3781 13781 Aubagne Aubagne Aubagne 13781 Cedex Cedex Aubagne Cedex Cedex Sartorius Sartorius Sartorius de México de Sartorius de México México S.A. de S.A. de S.A. México C.V. de de C.V. C.V. S.A. de C.V. 28108 Alcobendas (Madrid) 28108 Alcobendas (Madrid) 28108 28108 28108 Alcobendas Alcobendas Alcobendas 28108(Madrid) Alcobendas (Madrid) (Madrid)(Madrid) Circuito Circunvalación Poniente Singapore Circuito Circunvalación Poniente Singapore Circuito Circuito Circuito Circunvalación Circunvalación Circuito Circunvalación Circunvalación Poniente Poniente PonientePoniente Singapore Singapore Singapore Singapore Phone +33.442.845600 Phone+33.442.845600 +33.442.845600 ne hone Phone +33.442.845600 +33.442.845600 +33.442.845600 Phone +34.902.110.935 Phone +34.902.110.935 Sartorius Stedim Singapore Pte No.149 149 Sartorius Stedim Singapore Pt Phone Phone Phone +34.902.110.935 +34.902.110.935 +34.902.110.935 Phone +34.902.110.935 No.No. 149 No.149 149 No.No. 149 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Singapore Singapore Singapore Stedim Pte. Singapore Pte. Ltd. Pte. Ltd. Ltd.Pte. Ltd. Fax +33.442.846545 Fax+33.442.846545 +33.442.846545 +33.442.846545 ax Fax+33.442.846545 +33.442.846545 Fax +34.91.358.96.23 Fax +34.91.358.96.23 Ciudad Satélite 1Road, Ciudad Satélite 1Science Science ParkRoad, Road, FaxFax +34.91.358.96.23 Fax+34.91.358.96.23 +34.91.358.96.23 Fax +34.91.358.96.23 Ciudad Ciudad Ciudad Satélite Satélite Satélite Ciudad Satélite 1 Science 1 1Science Science Park 1Park Science Park Road, Road, ParkPark Road, 53100, Estado dedeMéxico The Capricorn, #05-08A, 53100, Estado México TheThe The Capricorn, #05-08A, 53100, 53100, 53100, Estado Estado Estado 53100, de México dede Estado México México de México Capricorn, TheCapricorn, Capricorn, The#05-08A, Capricorn, #05-08A, #05-08A, #05-08A, Austria Austria México Singapore México Singapore ustria Austria ria México México México México Singapore Singapore Singapore Science Singapore Science Science Park Park Science Park II IIScience IIScience Park Park IIParkII II Switzerland Switzerland Switzerland Switzerland Switzerland Switzerland Sartorius Stedim Austria GmbH Sartorius Stedim Austria GmbH Singapore 117528 Singapore 117528 orius artorius Sartorius Stedim Stedim Sartorius Stedim Austria Austria Austria Stedim GmbH GmbH GmbH Austria GmbH Singapore Singapore Singapore 117528 Singapore 117528 117528 117528 Sartorius Stedim Switzerland AG Sartorius Stedim Switzerland AG Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Switzerland Switzerland Switzerland Stedim AG Switzerland AG AG AGPhone Phone Phone +52.5555.62.1102 +52.5555.62.1102 +52.5555.62.1102 Phone +52.5555.62.1102 Phone +52.5555.62.1102 Phone +52.5555.62.1102 ranzosengraben zosengraben Franzosengraben Franzosengraben 12 1212 12 Franzosengraben 1212 Franzosengraben Ringstrasse Ringstrasse Ringstrasse 24 Ringstrasse 24 aRingstrasse 24a a 2424a24a a Ringstrasse FaxFax +52.5555.62.2942 Fax+52.5555.62.2942 +52.5555.62.2942 FaxFax +52.5555.62.2942 Phone Phone Phone +65.6872.3966 +65.6872.3966 +65.6872.3966 Phone +65.6872.3966 Phone +65.6872.3966 Fax+52.5555.62.2942 +52.5555.62.2942 Phone +65.6872.3966 0030 1030 Vienna Vienna Vienna 1030 Vienna 1030Vienna Vienna 8317 8317 8317 Tagelswangen Tagelswangen Tagelswangen 8317 Tagelswangen 8317 Tagelswangen 8317 Tagelswangen FaxFax +65.6778.2494 Fax+65.6778.2494 +65.6778.2494 Fax +65.6778.2494 Fax Fax+65.6778.2494 +65.6778.2494 ne hone Phone +43.1.7965763.18 +43.1.7965763.18 +43.1.7965763.18 Phone +43.1.7965763.18 Phone+43.1.7965763.18 +43.1.7965763.18 Phone Phone Phone +41.52.354.36.36 +41.52.354.36.36 +41.52.354.36.36 Phone +41.52.354.36.36 Phone +41.52.354.36.36 Phone +41.52.354.36.36 +43.1.796576344 ax Fax+43.1.796576344 +43.1.796576344 Fax +43.1.796576344 Fax+43.1.796576344 +43.1.796576344 FaxFax +41.52.354.36.46 Fax+41.52.354.36.46 +41.52.354.36.46 Fax +41.52.354.36.46 South South South Korea Korea Korea South Korea Fax +41.52.354.36.46 Fax +41.52.354.36.46 South Korea South Korea Sartorius Sartorius Sartorius Korea Korea Sartorius Korea Biotech Biotech Biotech Korea Co.,Korea Co., Ltd. Biotech Co.,Ltd. Ltd. Co., Ltd. Sartorius Biotech Co., Sartorius Korea Biotech Co.,Ltd Lt elgium Belgium ium Belgium 8th 8th Floor, 8th Floor, Floor, Solid 8th Solid Solid Space Floor, Space Space B/D, Solid B/D, B/D, Space B/D, B/D, Belgium Belgium 8th Solid 8thFloor, Floor, SolidSpace Space B/D, U.K. U.K. U.K. U.K. U.K. U.K. PanGyoYeok-Ro 220, BunDang-Gu orius artorius Sartorius Stedim Stedim Sartorius Stedim Belgium Belgium Belgium Stedim N.V. N.V. Belgium N.V. N.V. PanGyoYeok-Ro PanGyoYeok-Ro PanGyoYeok-Ro 220, 220, 220, BunDang-Gu BunDang-Gu BunDang-Gu Australia Australia Australia Australia Sartorius SartoriusStedim StedimBelgium BelgiumN.V. N.V.Sartorius PanGyoYeok-Ro PanGyoYeok-Ro220, 220,BunDangBunDang Australia Australia Sartorius Sartorius Stedim Stedim Sartorius Stedim UK UK Ltd. UK Stedim Ltd. Ltd. UKUK Ltd. Sartorius Stedim Ltd. Sartorius Stedim UK Ltd. Sartorius SeongNam-Si, GyeongGi-Do, euvensesteenweg, ensesteenweg, Leuvensesteenweg, Leuvensesteenweg, 248/B 248/B 248/B 248/B SeongNam-Si, SeongNam-Si, GyeongGi-Do, GyeongGi-Do, GyeongGi-Do, 463-400 463-400 463-400463-40 Sartorius Sartorius Stedim Stedim Sartorius Stedim Australia Australia Australia Stedim Pty. Pty. Australia Ltd. Pty. Ltd. Ltd.Pty.Pty. Ltd. Leuvensesteenweg, 248/B Leuvensesteenweg, 248/B SeongNam-Si, GyeongGi-Do, 464 SeongNam-Si, GyeongGi-Do, Sartorius Stedim Australia Ltd. Sartorius Stedim Australia Pty.SeongNam-Si, Ltd. Longmead Longmead Longmead Business Longmead Business Business Centre Centre Business Centre Centre Longmead Business Centre Longmead Business Centre Unit 0800 1800 Vilvoorde Vilvoorde Vilvoorde 1800 Vilvoorde Unit Unit 5, 7-11 5, 5, 7-11 7-11 Unit Rodeo Rodeo Rodeo 5, Drive 7-11 Drive Drive Rodeo Drive 1800 1800Vilvoorde Vilvoorde Unit Unit5,5,7-11 7-11Rodeo RodeoDrive Drive Phone Blenheim Blenheim Blenheim Road, Blenheim Road, Road, Epsom Epsom Epsom Road, Epsom Phone +82.31.622.5700 Phone Phone +82.31.622.5700 +82.31.622.5700 +82.31.622.5700 Blenheim Road, Epsom Blenheim Road, Epsom Phone +82.31.622.5700 Phone +82.31.622.5700 Dandenong Dandenong Dandenong South Dandenong South South Vic Vic 3175 Vic South 3175 3175 Vic 3175 Dandenong DandenongSouth SouthVic Vic3175 3175FaxFax Surrey Surrey Surrey KT19 KT19 KT19 9Surrey QQ 9 9QQ QQ KT19 9 9QQ Fax +82.31.622.5799 ne hone Phone +32.2.756.06.80 +32.2.756.06.80 +32.2.756.06.80 Phone +82.31.622.5799 Fax+82.31.622.5799 +82.31.622.5799 Surrey KT19 Surrey KT19 9QQ QQ Phone +32.2.756.06.80 Phone+32.2.756.06.80 +32.2.756.06.80 Fax Fax+82.31.622.5799 +82.31.622.5799 +32.2.756.06.81 ax Fax+32.2.756.06.81 +32.2.756.06.81 Fax Phone Phone Phone +61.3.8762.1800 +61.3.8762.1800 +61.3.8762.1800 Phone +61.3.8762.1800 Fax +32.2.756.06.81 Fax+32.2.756.06.81 +32.2.756.06.81 Phone Phone Phone +44.1372.737159 +44.1372.737159 +44.1372.737159 Phone +44.1372.737159 Phone +61.3.8762.1800 Phone +61.3.8762.1800 Phone +44.1372.737159 Phone +44.1372.737159 FaxFax +61.3.8762.1828 Fax +61.3.8762.1828 +61.3.8762.1828 Fax +61.3.8762.1828 FaxFax +44.1372.726171 Fax+44.1372.726171 +44.1372.726171 Fax +44.1372.726171 Fax Fax+61.3.8762.1828 +61.3.8762.1828 Fax +44.1372.726171 Fax +44.1372.726171 gary Hungary ungary Hungary Hungary Hungary orius artorius Sartorius Stedim Stedim Sartorius Stedim Hungária Hungária Hungária Stedim Kft.Hungária Kft. Kft. Kft. Ukraine China China China China UkraineUkraine Sartorius Stedim Hungária Kft. Sartorius Stedim Hungária Kft. Ukraine China China Ukraine Ukraine yló agyló Kagyló u. 5u.u.Kagyló 55 u. 5 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Biotech Biotech Biotech Stedim (Beijing) (Beijing) (Beijing) Biotech Co.Co. Ltd. (Beijing) Co.Ltd. Ltd. Co. Ltd. LLCLLC “Biohit” LLC“Biohit” “Biohit” LLC “Biohit” Kagyló Kagylóu.u.5 5 Sartorius SartoriusStedim StedimBiotech Biotech(Beijing) (Beijing)Co. Co.Ltd. Ltd. LLC “Biohit” LLC “Biohit” 2092 2092 Budakeszi Budakeszi Budakeszi 2092 Budakeszi No.No. 33 No.33 Yu’an 33Yu’an Yu’an No. Road Road 33 Road Yu’an Road Post Post Post Box Box 440 Box 440 Post “B” 440 “B” Box “B” 440 “B” 2092 2092Budakeszi Budakeszi No. 33 Yu’an Road No. 33 Yu’an Road Post Box 440 “B” Post Box 440 “B” Airport Airport Airport Industrial Industrial Industrial Airport Park Industrial Park Park Zone Zone Zone B Park B B Zone B 01001 01001 01001 Kiev, Kiev, Kiev, Ukraine 01001 Ukraine Ukraine Kiev, Ukraine ne hone Phone +36.23.457.227 +36.23.457.227 +36.23.457.227 Phone +36.23.457.227 Airport Industrial Park Zone Airport Industrial Park ZoneBB 01001 01001Kiev, Kiev,Ukraine Ukraine Shunyi Shunyi Shunyi District, District, District, Shunyi Beijing Beijing District, Beijing 101300 101300 101300 Beijing 101300 Phone +36.23.457.227 Phone +36.23.457.227 +36.23.457.147 ax Fax+36.23.457.147 +36.23.457.147 Fax +36.23.457.147 Shunyi ShunyiDistrict, District,Beijing Beijing101300 101300 Phone Phone Phone +380.44.411.4918 +380.44.411.4918 +380.44.411.4918 Phone +380.44.411.4918 Fax Fax+36.23.457.147 +36.23.457.147 Phone +380.44.411.4918 Phone +380.44.411.4918 Phone Phone Phone +86.10.80426516 +86.10.80426516 +86.10.80426516 Phone +86.10.80426516 FaxFax +380.50.623.3162 Fax+380.50.623.3162 +380.50.623.3162 Fax +380.50.623.3162 Phone Phone+86.10.80426516 +86.10.80426516 Fax Fax +86.10.80426580 Fax +86.10.80426580 +86.10.80426580 Fax +86.10.80426580 Fax +380.50.623.3162 Fax +380.50.623.3162 Italy aly Italy Fax Fax+86.10.80426580 +86.10.80426580 Italy Italy orius artorius Sartorius Stedim Stedim Sartorius Stedim Italy Italy Italy S.p.A. Stedim S.p.A. S.p.A. Italy S.p.A. Sartorius Stedim Italy Sartorius Stedim ItalyS.p.A. S.p.A. dell’Antella, ia Viadell’Antella, dell’Antella, Via 76/A dell’Antella, 76/A 76/A 76/A Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Biotech Biotech Biotech Stedim (Beijing) (Beijing) (Beijing) Biotech Co.Co. Ltd. (Beijing) Co.Ltd. Ltd. Co. Ltd. Via 76/A Viadell’Antella, dell’Antella, 76/A Sartorius Stedim Biotech Sartorius Stedim Biotech(Beijing) (Beijing)Co. Co.Ltd. Ltd. 12 0012 50012 Antella-Bagno Antella-Bagno Antella-Bagno 50012 Antella-Bagno a Ripoli a aRipoli Ripoli (FI) (FI) a(FI) Ripoli (FI) Shanghai Shanghai Shanghai Branch Shanghai Branch Branch Office Office Office Branch Office 50012 50012Antella-Bagno Antella-Bagnoa aRipoli Ripoli(FI) (FI) Shanghai Branch Shanghai Branch 3rd3rd Floor, 3rdFloor, Floor, North 3rd North North Wing, Floor, Wing, Wing, North Tower Tower Tower Wing, 1 1Office 1Office Tower 1 ne hone Phone +39.055.63.40.41 +39.055.63.40.41 +39.055.63.40.41 Phone +39.055.63.40.41 3rd Floor, North Wing, 3rd Floor, North Wing,Tower Tower1 1 No.No. 4560 No.4560 4560 Jin Jin No. Ke Jin Ke Road 4560 KeRoad Road Jin Ke Road Phone +39.055.63.40.41 Phone +39.055.63.40.41 +39.055.63.40.526 ax Fax+39.055.63.40.526 +39.055.63.40.526 Fax +39.055.63.40.526 No. Jin Road No.4560 4560 JinKe Ke Road 201210 Pudong Pudong Pudong District, District, Pudong District, Shanghai Shanghai District, Shanghai 201210 Shanghai 201210 201210 Fax Fax+39.055.63.40.526 +39.055.63.40.526 Pudong PudongDistrict, District,Shanghai Shanghai201210 201210 Phone Phone Phone +86.21.68782300 +86.21.68782300 +86.21.68782300 Phone +86.21.68782300 Phone +86.21.68782300 +86.21.68782332 |+86.21.68782300 68782882 FaxFax Fax+86.21.68782332 +86.21.68782332 FaxPhone +86.21.68782332 | 68782882 | 68782882 | 68782882 +86.21.68782332| 68782882 | 68782882 Fax Fax+86.21.68782332 Sartorius Sartorius Sartorius Stedim Stedim Sartorius Stedim Biotech Biotech Biotech Stedim (Beijing) (Beijing) (Beijing) Biotech Co.Co. Ltd. (Beijing) Co.Ltd. Ltd. Co. Ltd. Guangzhou Guangzhou Guangzhou Representative Guangzhou Representative Representative Office Office Office Office Sartorius Stedim Biotech (Beijing) SartoriusRepresentative Stedim Biotech (Beijing)Co. Co.Ltd. Ltd. Unit Unit Unit K, Building K,K,Building Building Unit 23 K,23 Building 23 23 Guangzhou Representative Guangzhou RepresentativeOffice Office Huihua Huihua Huihua Commerce Commerce Commerce Huihua &K, Commerce Trade &Building &Trade Trade Building Building & Building Trade Building Unit 2323 Unit K, Building No.No. 80 No.80 Xianlie 80Xianlie Xianlie No. Middle 80 Middle Middle Xianlie Road Road Road Middle Road Huihua Commerce &&Trade Huihua Commerce TradeBuilding Building Guangzhou Guangzhou Guangzhou 510070 Guangzhou 510070 510070 510070 No. No.8080Xianlie XianlieMiddle MiddleRoad Road Guangzhou Guangzhou 510070 Phone Phone Phone +86.20.37618687 +86.20.37618687 +86.20.37618687 Phone +86.20.37618687 | 37618651 |510070 37618651 | 37618651 | 37618651 FaxFax +86.20.37619051 Fax+86.20.37619051 +86.20.37619051 FaxPhone +86.20.37619051 Phone+86.20.37618687 +86.20.37618687| 37618651 | 37618651 Fax Fax+86.20.37619051 +86.20.37619051 www.sartorius-stedim.com www.sartorius-stedim.com www.sartorius-stedim.com www.sartorius-stedim.com www.sartorius-stedim.com www.sartorius-stedim.com Specifications subject to change without notice. Printed in the EU on paper bleached without chlorine. | W Publication No.: SBI1513-e141106 · Order No.: 85032-542-70 · Ver. 11 | 2014 Asia|Pacific Asia|Pacific Asia|Pacific Asia|Pacific Asia Asia||Pacific Pacific