BIOSTAT® B The Multi-Talented Bioreactor for Research

Transcription

BIOSTAT® B The Multi-Talented Bioreactor for Research
BIOSTAT ® B
The Multi-Talented Bioreactor for
Research and Development
BIOSTAT® B
at a Glance
Our BIOSTAT® B is the ideal benchtop bioreactor for your
lab. The multi-talented control tower opens up a new
world of flexibility for your changing requirements. Use
it as single or twin configuration, chose your cultivation
chamber from our proven range of options:
– Conventional stirred tank glass vessels
– Single-use stirred tank vessel Univessel® SU
– Wave-mixed Flexsafe RM bags
Applications
– Process development
and optimization
– Scale-up and scaledown
studies
– Seed expansion
– Cell bank production
– Protein supply
Cells
– Mammalian
– Insect
– Microbial
– Yeast
– Fungi
Industries
– Biopharmaceuticals
– Vaccines
– Cell therapies
– Industrial biotechnology
– Basic research
– Education
Process Modes
– Batch
– Fed-batch
– Continuous
– Perfusion
Proven Technology
With several thousand installations in
over 50 countries, BIOSTAT® B is the most
successful benchtop bioreactor in the
world. Benefit from our experience and
collaboration with customers worldwide.
Configurable Design
Contact your Sartorius representative
and configure your BIOSTAT® B bioreactor
solution matching your specific needs.
Benefit from our flexible and scalable
options.
Reliable Quality
Every BIOSTAT® B is thoroughly tested
before it leaves our production facilities in
Germany. Benefit from our global service
and application specialist network for
professional installation and training.
UniVessel® Glass
Our proven autoclavable borosilicate
glass culture vessel is available in four
different volumes: 1 L, 2 L, 5 L and 10 L,
for all kinds of cell culture and microbial
applications.
Benefits
−− Classic stirred-tank design simplifies
your scale-up and scale-down studies
−− Extensive performance and
engineering data package available
−− Save additional investment and use
our special design for small autoclaves
Fully interchangable glass
and single-use stirred-tank
culture vessels.
UniVessel® SU
Our single-use 2 L stirred tank vessel
for cell culture applications combines
scalable design with all benefits of
disposable solutions. No more worries
about challenging timelines, workload
or cross-contamination. Get started
within minutes.
Benefits
−− Fully single-use vessel, DO and
pH sensors
−− Proven, scalable stirred tank design
−− Connection kit to upgrade existing
bioreactor controllers
BIOSTAT® B –
The Universal Controller
for Your Lab
Main Applications
−− Mammalian, insect, microbial and plant cell culture
−− Process development, optimization, characterization
−− Seed and small scale production
−− Protein supply
Main Applications
−− Mammalian, insect and plant cell culture
−− Process development, optimization, characterization
−− Seed and small scale production
−− Production of cell banks
Watch Video:
www.sartorius.com/ video-biostat-b
Main Applications
−− Mammalian, insect, plant and low density
microbial culture
−− Seed and small scale production
−− Protein supply
−− Stem cell expansion and production
RM Rocker
Our proven wave-mixed bioreactor consists of a rocker unit with
bag holder and pillow-shaped Flexsafe RM single-use bags for
culture volumes from 100 mL to 25 L. Use it as basic system or in
combination with the BIOSTAT® B control tower and single-use
optical pH and DO sensors to enable advanced control strategies
for batch, fed-batch and continuous perfusion.
Benefits
−− Optimized film formula, traceability of
raw materials and control of the entire
Flexsafe RM bag manufacturing process
assure excellent and consistent cell
growth of the most sensitive cell lines
−− Space-saving, individual control of two
RM bags on the same rocker platform
−− Easy-to-use rocker with advanced alarms
and safety features for reliable cultivation
12” Touch Screen
with closed frame; protected
against water splashes and
dust deposits. Easy-to-use and
reliable operation of your
­BIOSTAT® B due to intuitive
design of human-machine­
interface and advanced touchscreen technology – even while
wearing laboratory gloves.
New Standards for
Interference-Free
Measurements
All inlets and ports for, e.g.
cooling water, process gasses,
electricity, ethernet and potential-free alarm contact are
located on the rear panel of the
control tower. An equipotential
bonding conductor shields the
bioreactor against electromagnetic current and ensures interference-free measurements
during your processes.
Control Tower
The control tower contains
both the aeration, pump and
temperature control modules,
saving valuable bench space in
your lab.
BIOSTAT® B
Configurable Flexibility
Single | Twin Control Tower
One BIOSTAT® B control tower can control up to two vessels completely
independently to save valuable lab space. Select culture vessel types
and volumes from our range of options, e.g. glass vessel, single-use vessel
or wave-mixed Flexsafe® RM bags.
Fast Load Peristaltic
Pumps
Insert the tubing in seconds:
Open, insert tube, close, done!
No more pinched fingers or
torn gloves. Up to four internal
pumps can be selected per
vessel. Choose between speedcontrolled pumps and fixedspeed pumps for feed and
corrective agent addition.
Connections for
Sensors and External
Accessories
Quick-connect couplings make
it easy to attach all cables and
supplies to the culture vessels.
All connections are clearly
marked with the same names
used on the rear control tower
panel and in the local control
software menu for fast, error
proof identification.
Storage Tray
A storage tray for accessories
helps you organize your
workplace.
Aeration Strategies
A series of flexible aeration options turns the BIOSTAT® B into a multitalented bioreactor for a wide range of different applications, including
high-cell density microbial fermentation requiring considerable amounts
of oxygen to high-cell density cell culture applications requiring removal
of excessive carbon dioxide.
Microbial Applications
in Combination with UniVessel® Glass
Various controller and hardware configurations enable aeration strategies using air
or oxygen or classical O2 enrichment of air.
For anaerobic processes, the air inlet can
be used for nitrogen. The standard built-in
solenoid valves in combination with a flow
meter ensure reliable gas supply for simple
applications. Optional mass flow controllers provide exact flow rate control of
individual gases. In combination with
BioPAT® Xgas off-gas analysis, this allows
mass balancing consumed and produced
gases.
Gas Inlet
Solenoid Valve MFC*
(max. 2)
(max. 2)
Air
Flow
Meter
Gas Outlet
Sparger
O2
*MFC = mass flow controller
Cell Culture and Multi-Purpose Applications
in Combination with UniVessel® Glass and UniVessel® SU
Gas Inlet
Solenoid Valve MFC *
(4 max.)
(4 max.)
Flow Meter
Gas Outlet
Overlay
Air
Sparger
O2
N2
CO2
Switching CO2 from sparger to overlay
*MFC = mass flow controller
Five different gas lines, equipped with
solenoid valves and|or up to four optional
mass flow controllers and flow meters
deliver ultimate flexibility and accuracy.
The ­BIOSTAT® B allows you to optionally
switch between sparger and overlay supply
of CO2 for pH control. In addition, a constant air | CO2 mixture can be created in
the overlay line to reproduce conditions
like those prevailing in a CO2 incubator.
Cell Culture Applications
in Combination with Our Rocking-Motion Bioreactor
The wave generated in the RM bags due
to the rocking motion ensures effective
gas exchange through the gas-liquid
interface. Four different gas lines for air,
O2, N2 and CO2 are equipped with flow
meters and four high-precision mass flow
controllers. An integrated pressure sensor
continuously measures the pressure inside
the bag. To ensure process safety, aeration
is switched off when an upper threshold
is reached.
Gas Inlet
MFC*
Flow
Meter
Gas Outlet
Overlay
Air
O2
N2
CO2
*MFC = mass flow controller
You can configure your BIOSTAT® B
aeration system in a similar way as your
BIOSTAT® STR single-use stirred tank
bioreactor. Get ready for seamless scale-up
and -down, from laboratory scale to
large scale single-use production.
DCU – Local Control
Since we introduced the first DCU-controlled bioreactors back in the late
80’s, we have installed thousands of such bioreactors to date at leading
companies in the pharmaceutical and biotech industry worldwide. We have
continuously improved our robust, intuitive-use and industry-proven DCU
control technology, now available in its fourth generation. It is our standard
local control platform for our BIOSTAT® bioreactors, SARTOFLOW® crossflow
filtration units and FlexAct® configurable systems available for a large
number of unit operations.
The intuitive touch screen on the control tower is used to locally operate the BIOSTAT® B:
Aeration control
Balances and gravimetric flow control
Overview
of process
parameters
Pump
module
Submenus
Overview and close-up
Culture vessels
Status display
Automatic Feed Control and
Continuous Processing
Design your process strategy or select different options. Configure your BIOSTAT® B
with gravimetric feed control, gravimetric
level control or substrate addition profiles.
This enables you to run your BIOSTAT® B
in batch, fed-batch, continuous or perfusion mode.
Automatic DO Control
Besides classic DO cascade control, we
have developed the unique advanced DO
controller that gives you more flexibility
to develop and optimize your DO control
strategy.
The advanced DO controller supports parallel adjustment of all DO affecting parameter settings like stirrer speed and gas flow
rates of air and pure oxygen, automatically
and simultaneously to control the DO set
point. Optionally, you can keep the total
gas flow rate constant and the ratio of
pure oxygen in the gas mixture is increased
automatically to match the oxygen consumption of the culture. This gives you ultimate flexibility to adapt your aeration
strategy to your process requirements.
Automatic pH Control
Control the pH of your culture by automatic acid and base addition or by CO2
aeration and base addition. If you want
to use your BIOSTAT® B for both microbial
and cell culture you can configure your
bioreactor system with a combined acid
control via CO2 aeration and acid addition.
CO2
Base Acid
BioPAT® MFCS – SCADA Process Control
BioPAT® MFCS is a multi-functional supervisory control and data acquisition software,
specifically developed for bioprocessing applications in upstream and downstream.
Every BIOSTAT® bioreactor comes with basic data recording functionality of our BioPAT®
MFCS. Rely on more than 7,000 installations worldwide and over 25 years of experience.
– Multi-user network access for up to 16 process units
– On-line and off-line sample data management, visualization, evaluation
– Remote monitoring, control and alarming
BioPAT® MFCS | win
In addition to providing a genuine SCADA system for conventional and single-use
bioprocess applications, the optional advanced version of BioPAT® MFCS includes
a series of add-on modules:
– Bioprocess optimization with Design
of Experiments module (DoE)
– Automation with recipes according to
ANSI | ISA-88.01
– 21 CFR, Part 11 compatibility
– Secure integration into company
networks
– Flexible device connection facility
through OPC
– Expanded data recording and data
archiving capabilities
– Alarm recording and transmission
to multimedia devices
Our Mission Is Your Productivity
We are well aware of how important smooth-running equipment is for effective process
development and efficient production. That is why we at Sartorius offer you a broad range
of preventive technical service, repair and application specialist support. Our ISO certified
quality management system ensures that you receive equipment and services that meet
the strictest quality requirements. Become one of our many customers who benefit from
our local presence worldwide, highly qualified specialists and well-versed technicians.
Services Offered for BIOSTAT® B
−− On-site installation and application
specialist support, ensuring that your
equipment is perfectly up and unning
right from the start
−− Factory acceptance and site-acceptance
testing
−− On-site preventive maintenance and
repair
−− Consumable and spare part kits
Technical Specifications
BIOSTAT® B
Control Tower Weight
Single | Twin
~ 40 | 55 kg (88 | 121 lbs.)
Control Tower Dimensions (W + H + D)
Single | Twin
410 + 810 + 520 mm (16“ + 32“ + 20“)
Utility Connections
Power supply
– 230 V (± 10%), 50 Hz, max. power consumption 10 A
– 120 V (± 10%), 60 Hz, max. power consumption 12 A
– Potential equalisation
International protection rating
IP21
Gases
– Gas supply pressure, 1.5 barg
– Dry, oil and dust-free
– Hose barb for tubing, external dia. = 6 mm
Water
– Water supply pressure, 2 – 8 barg
– Flow rate up to 20 lpm
– Temperature min. = 4°C
– Discharge pressure-less
– Hose barb for tubing, external dia. = 10 mm
– Degree of hardness: 12 dH max.
Control Tower
Housing
Stainless steel, AISI 304
Display
Touch screen, 12”, glass, capacitive
Resolution
125 dpi
SCADA communication
Industrial Ethernet
Potential-free (common) alarm contact
•
Safety valve gas pressure
1 bar (14.5 psi) for UniVessel® Glass and SU | 100 mbar for RM
Water inlet pressure reduction
1.5 bar (22 psi), integrated pressure control
®
Motor Drive (Univessel Glass | SU)
Maintenance-free, quiet direct drive
Power: 200 W
Maintenance-free top drive with
magnetic motor coupling
Power: 200 W
Rotation speed motor, direct coupling
1L: 20 – 2,000 rpm
2L: 20 – 2,000 rpm
5L: 20 – 1,500 rpm
10L: 20 – 800 rpm
2L SU: 20 – 400 rpm
Rocker Platform
Power supply
– 230 V (± 10%), 50 Hz, power consumption 10 A
– 120 V (± 10%), 60 Hz, power consumption 12 A
Power consumption
600 W
International protection rating
IP23
Rocking speed
8 – 42 ± 1 (r/min)
Rocking angle
4 –10 ± 0.3 (°)
Process Control | Sensors
UniVessel®
Glass
UniVessel®
SU
Rocking
Motion
Pt100 | 0–150°C (temperature control
0-80°C) | 0.1°C
•
•
•
Dissolved oxygen, reusable
Polarographic or optical | 0–100 % | 0.1 %
•
•
Dissolved oxygen, single-use
Range: 0 –100 %
Precision: 0.1%
pH, reusable
Combined measuring electrode Range: 2–12 pH Precision: 0.01 pH
pH, single-use
Range: 6.5 - 8.5 pH
Precision: 0.1 pH
Foam control
Electrical conductive sensor,
stainless steel, ceramic insulated
•
Level
Electrical conductive sensor, stainless
steel, ceramic insulated
•
Turbidity
1-channel NIR absorption sensor | 0–6 AU | 0,01 AU
•
Redox
Combined measurement with
pH sensor | -1,000 – 1,000 mV | 1 mV
•
•
Balance substrate
7 kg max. | 1 g
60 kg max. | 2 g
300 kg max. | 100 g
•
•
Balance culture vessel
60 kg max. | 2 g
•
•
RM load cells
30 kg max. | 10 g
Weight: 9 kg
Dimensions: 609 | 536 | 60-68 mm
100–240 V VAC | 24 VDC | 15 W
External signal input
0–10 V or 4-20 mA
UniVessel® Glass | SU: 4 max.
Rocker: 2 max.
Sensor | Measurement Range | Display Accuracy
Temperature
•
•
•
•
•
•
•
•
•
•
•
Aeration Module
Outlet to culture vessel | bag
®
UniVessel Glass MO (Microbial)
Hose coupling d external = 6 mm
Two-gas mixing with sparger outlet
AIR with O2 Enrichment or Gas Flow Ratio mixing along with anaerobic fermentation; for further information,
please see page on “aeration strategies”
Max. total flow
Up to 20 l/min total volume flow
Flow rate controllers
2
Flow rate controller range
Various models available: 0.1-20 liters per min. [lpm] (sparger)
Accuracy of flow rate controllers
± 5 % full scale
Mass flow controllers (optional)
2 max.
Flow rates of mass flow controllers
Various models available: 0.03-20 lpm (sparger)
Accuracy of mass flow controllers
± 1 % full scale
®
UniVessel Glass CC (Cell Culture) | UniVessel® SU
Four-gas mxing with sparger and headspace outlet
Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies”
Max. total flow
Up to 13 l/min total volume flow
Number of flow rate controllers
5
Flow rate controller range
Various models available:
3.3 ccm – 1.6 lpm (sparger)
0.16 lpm – 13 lpm (headspace)
Accuracy of flow rate controllers
± 5 % FS
Mass flow controllers (optional)
4 max.
Flow rates of mass flow controllers
Various models available:
1 ccm – 1.5 lpm (sparger)
0.03 lpm – 10 lpm (headspace)
Precision of mass flow controllers
± 1 % FS
UniVessel® Glass, Dual Use
Four-gas mixing with sparger and headspace outlet
Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies”
Max. total flow
Up to 20 l/min total volume flow
Flow rate controllers
5
Flow rate controller range
Various models available:
3.3 ccm – 20 lpm (sparger)
50 ccm – 20 lpm (headspace)
Accuracy of flow rate controllers
± 5% full scale
Mass flow controllers (optional)
4 max.
Flow rates of mass flow controllers
Various models available:
0.6 ccm – 20 lpm (sparger)
10 ccm – 20 lpm (headspace)
Precision of mass flow controllers
± 1 % FS
Rocker
Four-gas mixing with sparger and headspace outlet
Additive flow, 4-gas (Air, O2, N2, CO2) mixture; for further information, please see page on “Aeration Strategies”
Max. total flow
Up to 10 l/min total volume flow
Max. CO2 flow
One bag: 1 + 1 lpm
Twin bag: 2 + 0.5 lpm
CO2 concentration controller
0.8 % – 15% | ± 5%
Flow rate controllers
4
Flow rate controller range
Various models available:
16 ccm – 36 lpm (headspace)
Accuracy of flow rate controllers
± 5% full scale
Mass flow controllers (optional)
2 max.
Flow rates of mass flow controllers
Various models available:
3 ccm – 3 lpm (headspace)
Precision of mass flow controllers
± 1% full scale
Pump Module
Built-in Pumps
Fixed speed (on | off controlled)
Watson Marlow 114, Fast Load pump head
– Speed 5 rpm
Flow rate (tubing wall thickness 1.6 mm)
ID: 0.5 mm: 0–0.1 ml/min
ID: 0.8 mm: 0.05–2.4 ml/min
ID: 1.6 mm: 0.01–0.7 ml/min
ID: 2.4 mm: 0.03–1.5 ml/min
ID: 3.2 mm: 0.05–2.4 ml/min
ID: 4.8 mm: 0.09–4.3 ml/min
– Speed 44 rpm
Flow rate (tubing wall thickness 1.6 mm)
ID: 0.5 mm: 0.02–0.9 ml/min
ID: 0.8 mm: 0.04–1.8 ml/min
ID: 1.6 mm: 0.12–6.2 ml/min
ID: 2.4 mm: 0.26–12.8 ml/min
ID: 3.2 mm: 0.41–20.7 ml/min
ID: 4.8 mm: 0.75–37.4 ml/min
Speed-controlled
Watson Marlow 114, Fast Load pump head
– Speed 0.15–5 rpm
Flow rate (tubing wall thickness 1.6 mm)
ID: 0.5 mm: 0–0.1 ml/min
ID: 0.8 mm: 0.01–0.2 ml/min
ID: 1.6 mm: 0.02–0.7 ml/min
ID: 2.4 mm: 0.04–1.5 ml/min
ID: 3.2 mm: 0.07–2.4 ml/min
ID: 4.8 mm: 0.13–4.3 ml/min
– Speed 5–150 rpm
Flow rate (tubing wall thickness 1.6 mm)
ID: 0.5 mm: 0.1–3 ml/min
ID: 0.8 mm: 0.2–6 ml/min
ID: 1.6 mm: 0.7–21 ml/min
ID: 2.4 mm: 1.45–43.5 ml/min
ID: 3.2 mm: 2.35–70.5 ml/min
ID: 4.8 mm: 4.25–127.5 ml/min
External Pumps
Speed-controlled
Watson Marlow 120, Fast Load pump head,
up to 200 rpm
Temperature Control Module
Heating and Cooling
Heating Only
For UniVessel® Glass Single-wall Culture Vessels
Electrical heating system and automatic cooling water valve;
connection to heating blanket and cooling finger
–
Temperature control of 8°C above cooling-water inlet temperature up to 60°C
–
Heating blanket capacities 1 L | 2 L | 5 L | 10 L: 100 | 170 | 400 | 780 W
–
For UniVessel® Glass Double-wall (Jacketed) Culture Vessels
Open thermostat system with recirculation pump and automatic cooling
water valve
–
Temperature control of 8°C above cooling-water inlet temperature of up to 80°C –
Heating capacity: 600 W
–
For UniVessel® SU Single-use Culture Vessels
Open thermostat system with recirculation pump and automatic cooling
water valve; connection to heating | cooling jacket
Electrical heating blanket
Temperature control up to 50°C
Temperature control up to 50°C
Heating capacity 2L : 200 W
For BIOSTAT® RM Rocking-motion Bioreactor
Open thermostat system with recirculation pump and automatic cooling
water valve
Electrical heating plates
Temperature control of 8°C above cooling-water inlet temperature of up to 40°C
Temperature control from room
temperature up to 40°C
Heating capacity: 600 W
Heating plates: 2 + 140 W
Culture Vessel UniVessel® Glass
Autoclavable Single-wall or Double-wall
(Jacketed) Glass Vessel
1L
Material
Borosilicate glass, stainless steel AISI 316L, EPDM
Sizes [L]
1
2
5
10
Total volume [L]
1.6
3
6.6
13
Working volume [L]
0.4 –1
0.6 – 2
0.6 – 5
1.5 | 5 –10
Top port 19 mm | 12 mm | 6 mm
3 | 2 | 6
3 | 2 | 9
3 | 3 | 8
5 | 2 | 9
UniVessel®, Single-wall
1L
2L
5L
10 L
Weight1 [kg]
6
7
12
19
Space requirements in autoclave
[W + H + D mm]
200 + 540 + 270
230 + 600 + 300
260 + 730 + 340
330 + 860 + 420
480 + 410 + 300
530 + 510 + 410
540 + 630 + 420
Space requirements in autoclave, reduced2
[W + H + D mm]
®
2
5L
10 L
UniVessel , Double-wall
1L
2L
5L
10 L
Weight1 [kg]
7
8
14
23
Space requirements in autoclave
[W + H + D mm]
330 + 540 + 270
380 + 600 + 300
410 + 730 + 340
450 + 860 + 420
480 + 410 + 300
530 + 510 + 410
540 + 630 + 420
Space requirements in autoclave, reduced2
[W + H + D mm]
1
2L
With tripod and head plate, without medium
Adapter for exhaust cooler to reduce height in the autoclave optionally available
Culture Vessel UniVessel® SU
Single-use vessel made of pre-sterilized polycarbonate for cell culture applications
Total volume [L]
2.6
Working volume [L]
0.6–2
Max. temperature
50 °C
Operating pressure
< 0.5 barg
Basic Configurations
The BIOSTAT® B is a highly flexible and modular system that can be individually adapted to the
requirements of your application. Below you will find an overview of the basic equipment which
you can extend with diverse options. Please contact your Sartorius Stedim Field Representative
or Application Specialist for additional information.
Microbial Packages for UniVessel® Glass
Volume
Single
Twin
Digital controller, color display with touch screen
Control temperature, pH, DO, stirrer speed
Maintenance-free, quiet motor
Storage tray for accessories
Aeration module with 2 solenoid valves
2 flow rate controllers for manual flow rate control (AIR | N2, O2)
Software configured for microbial applications
4-stage DO cascade
BioPAT® MFCS software for data acquisition
2 integrated pumps for pH control (acid | base)
Temperature control module for double-wall vessels
2 external signals 0 –10 V
Standard test and documentation
Installation set for the gas and water connections
Power cable
Double-wall culture vessel
Stirrer shaft with single-mechanical seal and direct coupling
2 addition bottles for correction agents
Exhaust cooler
Aeration filters
Rushton impellers
Ring sparger
4-way addition port
Inoculation port
Harvest pipe, height-adjustable
Manual sampler
Tool set for disassembly of vessel
Pt100 temperature sensor
pH sensor
DO sensor, amperometric
Cell Culture Packages for UniVessel® Glass
Volume
Single
Twin
Digital controller, color display with touch screen
Control temperature, pH, DO, stirrer speed
Maintenance-free, quiet motor
Storage tray for accessories
Aeration module with 4 solenoid valves
5 flow rate controllers for manual flow rate control
(AIR Overlay, AIR sparger, N2, O2, CO2)
Software configured for cell culture applications
4-stage DO cascade
BioPAT® MFCS software for data acquisition
1 integrated pump for pH control (base)
Temperature control module for single-wall vessels
2 external signals 0 –10 V
Standard test and documentation
Installation set for the gas and water connections
Power cable
Single-wall culture vessel with tripod
Heating blanket 120 | 230 V
Stirrer shaft with single mechanical seal and direct coupling
1 addition bottle for correction agent
Exhaust cooler
Aeration filters
3-blade segment impeller
Microsparger
4-way addition port
Harvest pipe, height-adjustable
Manual sampler
Tool set for vessel dismantling
Pt100 temperature sensor
pH sensor
DO sensor, amperometric
Options
Control System
Advanced DO controller
Flexible switching CO2 from sparger to headspace
Software for dual use MO | CC
Mass flow controller
Antifoam control via sensor
Mechanical foam destroyer (MO applications)
Level control via sensor
Weight measurement substrates | culture vessel
Gravimetric feed | level control
Substrate addition via time profile
Redox (ORP) measurement
Turbidity measurement
BioPAT® Xgas O2 | CO2 off-gas analysis
System IQ | OQ
BioPAT® MFCS SCADA system
UniVessel® Glass
Double-wall culture vessel
Magnetic coupling for drive motor
STT connectors for safe inoculation and media transfer
Cooling finger (single-wall culture vessels)
Spin filter for perfusion mode
Aeration basket for organisms sensitive to shear stress
Rushton impellers | 3-blade segment impellers
Baffles
Bottle holder
Adapter for height reduction of exhaust cooler for the autoclave
Inoculation port
3-way addition port
Universal adapter ID 3.2 mm
Harvest pipe bent for complete draining
Port adapter 19 mm – 12 mm
Set of consumables
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B.V.
SartoriusStedim
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50012
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4560
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Ke
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District,
District,
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District,
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Shanghai201210
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(Beijing)
(Beijing)
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(Beijing)
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Sartorius
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(Beijing)
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23
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&
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80
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+86.20.37618687
+86.20.37618687
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