Spect/CT

NanoSPECT/CT
®
In Vivo Dual Modality SPECT/CT Animal Imager
Proprietary multi-pinhole SPECT *
Highest Sensitivity, Largest FOV
Full-ring of Broadband Detectors with
largest FOV and
highest intrinsic resolution
Eliminates SPECT trade-offs between
resolution, sensitivity and FOV
Single-motion, whole-body imaging with
largest axial FOV (up to 27cm)
Superior multi-nuclide imaging by energy
separation in multi-channel analyzers (MCA)
All SPECT radionuclides,
Including I-125 and I-131
Proprietary Helical and Static SPECT**
with up to 64 pinholes
Dynamic 4D, ECG- and
Respiratory-gated Imaging
* Patents: US 7,199,371 and EP 1,421,411
** Pending patent: US 20080087829
One-step SPECT and CT
with auto-fusion of images
Open system access with
plug-in cells for mice, rats, rabbits
Proprietary, multi-modality,
pathogen-free cells with
physiological control***
Compatible with
NanoScanCT, NanoPET/CT & MRI
***Pending Patent: WO2007135248
The Highest Performance and Most Acclaimed Preclinical SPECT System
Breakthrough Technologies for Breakthrough Science
NanoSPECT/CT®
Patented Multiplexed Multi-pinhole SPECT System
US 7,199, 371 and EP 1 421 411
“Preclinical Molecular Imaging”
NanoSPECT/CT is the first dual-modality functional preclinical scanner that
images animals, as small as mice, with the resolution and sensitivity required
to achieve the same image acuity as can be obtained from imaging humans
with clinical scanners.
Functional Imaging of Mice and Larger Animals
up to 5 kg, with the same visual acuity as humans
Translational imaging
“from mouse to man”.
Neuroscience
Human
Mouse
70 - 150 kg
20 - 60 kg
0,03 kg
0,30 kg
3 kg
Imaging of dopamine receptors in the striatum
5 kg
Cardiovascular
Mouse
Preclinical “NanoSPECT/CT”
Clinical
How NanoSPECT/CT meets the challenge of in vivo biological research
The use of SPECT for biological research in small animals presents several challenges
beyond those faced in clinical studies. First, small-animal imaging must achieve submillimeter resolution in all directions so that images in mice can be obtained with
the same visual acuity as in humans. Second, a high level of detection sensitivity is
needed to minimize the amount of radioactive probe that needs to be injected and to
allow procedures to be completed within a 20-45 minute period during which small
animals can be anesthetized safely. NanoSPECT/CT meets these challenges by using
patented multiplexed multi-pinhole SPECT technology, thus increasing sensitivity
ten-fold and improving resolution to the sub-mm or nanoliter range.
Human
Imaging of myocardial perfusion
Oncology
Mouse
Human
Imaging of kidney function/damage in oncology
How NanoSPECT/CT accelerates Preclinical Discovery
Optical (luminescence and fluorescence) imaging, single photon emission computed
tomography (SPECT) and positron emission tomography (PET) are used regularly in small
animal research to study the molecular bases of disease non-invasively, and to guide the
development of novel molecular-based treatments. Unlike optical imaging, SPECT and PET
can probe subtle molecular signals deep within tissue, making these technologies suited
for use in both small and large subjects. This ability to penetrate large subjects has lead to
the establishment of SPECT and PET as clinical standards of care and therefore, preclinical
discoveries and developments using these technologies are more likely to translate into the
clinic. The use of NanoSPECT/CT illustrates this translational capability by bridging the in-vitro
to in-vivo gap with tracers commonly used at the bench and in the clinic. Now,with a single
system, you can use the same imaging protocol, the same biomarkers, the same imaging
technology - from small to large subjects - and obtain the same information content as can be
obtained from scanning humans.
Tracer Versatility
from I-125 to I-131
from 28 KeV to 365 KeV
I-125
Tl-201
Ga-67
I-125
Bridging the in-vitro to in-vivo gap
Tc-99m
SPECT Biomarkers from Bench to Bedside
I-123
Bench Bedside
Thyroid uptake: 0.1 mCi
125
I in mouse
Courtesy S. Mather, UCL, London
Lu-177
In-111
I-131
I-131
Tumor uptake: 0.32 mCi 131I-CLR1404
in mouse
Courtesy J. Norenberg and Cellectar,
UNM, Albuquerque
Unprecedented Translational Imaging of Biomarkers with High
Spatial and Temporal Resolution
Excellent correlation
between autoradiography
and NanoSPECT/CT images
Oncology
Regenerative Medicine
Toxicology
CNS/Neurology
Respiratory/Pulmonary
Cardiovascular
Rheumatology/Arthritis
Nephrology
* refer to “Scientific Publications and Presentations”
111
In-octreotate uptake in tumor xenograft
Courtesy: M. de Jong, ErasmusMC, Rotterdam
NanoSPECT/CT®
Unique features enabling outstanding performance
Eliminate trade-offs between Resolution, Sensitivity & FOV
NanoSPECT/CT combines a full ring of proprietary Broadband Gamma
Ray Detectors™ with patented Multiplexed Multi-Pinhole SPECT
(MMP-SPECT®) to eliminate many of the sensitivity versus resolution
trade-offs associated with traditional SPECT systems. Unlike any other
pre-clinical SPECT system, NanoSPECT/CT offers high-resolution and
high-efficiency detection in a large FOV. As a result, the system can
perform fast and dynamic whole-body scans in a single-step procedure,
with high isotropic resolution. In fact, compared to any other preclinical SPECT system, imaging efficiency is improved by a factor of ten
at sub-mm resolution, making it the first molecular imaging modality
to achieve picomolar detector sensitivity and nanoliter volumetric
resolution.
This best-in-class SPECT is combined with low-dose, in-line X-ray CT
imaging using helical scanning and volumetric cone-beam technology.
We developed NanoSPECT/CT to work as a true dual-modality scanner
for longitudinal studies, so you can enhance your high-contrast
molecular SPECT images with high-definition CT for easier and better
quantitation of molecular images. Simple, single-motion SPECT and CT
allows one-step auto-fusion of images with the InVivoScope multimodality image display and analysis software.
Seamless In Vivo Dual-Modality
Animal Imaging
CT Multi-nuclide SPECT/CT
Multi-nuclide SPECT
NanoSPECT/CT Key features
Multiplexed Multi-Pinhole SPECT (MMP-SPECT) with up to 64 pinholes
increases imaging efficiency ten-fold, provides uniformity over a large field-ofview (FOV) and allows imaging at sub-mm resolution (as low as 400 µm)
Large Bore with Broadband Gamma Ray Detectors: one, two or four large
215 x 230 mm2 detectors with < 1mm2 pixel size enabling to image mice, rats,
rabbits, monkey heads and small dogs at high sensitivity and resolution
NaI(Tl)-Spectroscopy with Multi-Channel Analyzers (MCA) offers industryleading multi-nuclide imaging by analyzing and separating energy spectra of up
to three radionuclides simultaneously.
Wide Energy Range for Translational Research: allows using 125I at the bench
and 131I in the clinic - plus all other common clinical SPECT tracers, including
those used for radiotherapy applications.
High-quality, Low-Dose X-ray System permits longitudinal live-animal studies
at low X-ray doses and provides good soft tissue contrast with voxel resolutions
down to 39 µm.
High-Precision Gantry with Helical Scanning uses a common axis of rotation
and scan range for both SPECT and CT, allowing single-step SPECT/CT imaging
and fusion.
Open System Access with Plug-in Animal Imaging Cells optimizes workflow
with the ability to use several animal beds in parallel and ensures compatibility
with other modalities. The CT system functions as a FDA closed-cabinet design.
Pathogen-free Imaging Cells with Physiological Control for mice, rats,
marmoset monkeys and rabbits. Ensures reproducible imaging conditions
for longitudinal studies and provides a pathogen-free environment for
immunodeficient animals and infectious disease studies.
High Temporal Resolution for 4D, Cardiac- and Respiratory-Gated Imaging
extends the applications of pre-clinical SPECT to fast kinetic analysis
applications.
InVivoScope™ Integrated Analysis Software: powerful but simple-to-use multimodality image processing and analysis suite with breakthrough data extraction
and quantitation capabilities - CFR21 part 11 compatible.
NanoSPECT/CT High Resolution and Sensitivity
MMP-SPECT Resolution:
By using large-area detectors with high intrinsic resolution (<1 mm2 pixel
size) mounted on a high-precision gantry, our proprietary multiplexed multipinhole (MMP-SPECT) collimation and iterative image reconstruction allows the
NanoSPECT/CT to offer unmatched resolution at short scanning times:
Using 0.6 mm multi-pinhole apertures: FWHM <0.45 mm
Using 1.0 mm multi-pinhole apertures: FWHM <0.75 mm
Using 1.4 mm multi-pinhole apertures: FWHM <1.0 mm.
MMP-SPECT Sensitivity:
Up to four large SPECT detectors surround the animal and feature exclusive
multiplexed multi-pinhole collimation with 9 and up to 16 pinholes (optional) per
detector providing high and uniform sensitivity across the FOV. Actual sensitivity
values depend on the number of pinholes and detectors used.
Typical axial sensitivities for a 4-detector configuration for mouse imaging:
Tri-modality rat brain perfusion:
SPECT/CT images fused with MRI.
Courtesy: C. Ferris, Center for
Translational Imaging, Boston
I –iomazinil mouse brain
scan. Courtesy: H. Fujii,
NCC-East, Kashiwa
125
Sensitivity ≥ 4300 cps/MBq at Resolution ≤1.4mm for whole-body imaging (TFOV ≥30mm)
Sensitivity ≥ 2200 cps/MBq at Resolution ≤1.0mm for detailed whole-body studies (TFOV ≥ 30mm)
Sensitivity ≥ 1200 cps/MBq at Resolution ≤0.75mm for HR whole-body imaging (TFOV ≥ 30mm)
Sensitivity ≥ 600 cps/MBq at Resolution ≤0.45mm for UHR whole-organ imaging (TFOV ≤ 16 mm)
Up to 64 pinholes enable stationary SPECT:
In-vivo “SPECT-Microscopy”
Ultra-high resolution for Real-time SPECT
SPECT image of a mouse brain using 99mTc-HMPAO to visualize cerebral
blood flow Structures identified with help of mouse brain atlas
(Paxinos & Watson, Academic Press)
NanoSPECT: Why NaI(Tl)-Spectroscopy
outperforms systems based on CZT detectors
I [IBF] Uptake Striatum with NanoSPECT
123
Up to 44 pinholes for rotational SPECT:
Whole-body and focused SPECT scans
No matter how good the energy resolution of a detector, there are
other factors than just the detector characteristics that contribute
to overlapping radio-nuclide spectra in a SPECT system. Effects
such as attenuated gamma penetration in pinhole edges, scatter in
the object, back-scatter from surrounding materials and collimator
scatter, all contribute to overlapping spectra when imaging multiple
nuclides. The only accurate means to eliminate such nuclide spillover effects is by gamma spectrometry using full energy spectrum
analysis. This requires very stable, room temperature detectors
such as NaI(Tl) coupled to multi-channel analyzers to analyze and
accurately separate the energy spectra of multiple radio-nuclides
when imaged simultaneously, as illustrated below.
Separation of nuclide spectra with NaI(Tl) Spectroscopy
These unequalled multi-nuclide imaging capabilities are illustrated
in the following images published in 2008 by the SNM Molecular
Imaging Center of Excellence:
Helical scanning
(patent pending)
Focused scan and/or whole
body scan
Rotational SPECT
with full-ring of detectors
9 cm (mouse, 30g)
27 cm (rat, 400g)
Maintenance-free high-precision mechanical gantry with patented selfcalibrating helical scanning. Designed to eliminate axial blurring of SPECT
images and to accommodate a field-upgradeable cone-beam X-ray CT-scan
option with topographic ROI selection.
Simultaneous dual-isotope acquisition performed on a wild-type
mouse using the NanoSPECT/CT. 1 mCi of 99mTc-MDP and 200 µCi
of 123I-Tyr3-Octreotide were injected via tail-vein 3 hours prior to
imaging.
Courtesy: J.Norenberg and Cellcyte Genetics, UNM, Albuquerque
CT
SPECT/CT
Auto-fusion of SPECT/CT at work
Single-motion, dual-modality imaging with axial FOV of up to 24 cm
X-ray CT System Capabilities
Standard micro-focus X-ray source (5-8 μm spot size)
for high-quality whole-body and focused Imaging
Cardiac and Respiratory Gating
NanoSPECT’s unique ability to image with high-sensitivity at sub-mm resolution in
a large FOV makes it possible to perform challenging heart and lung applications in
mice. ECG and respiratory cycles are monitored in real-time to synchronize image
acquisitions. Image blur caused by cardiac and respiratory motion is eliminated,
and details such as the right ventricular wall stay visible throughout the cardiac
cycle - all beneficial features in cardiac imaging, where end-systolic and enddiastolic measurements are key.
Courtesy: D. Mathe, OSSKI, Budapest
Low-dose X-ray system for high tissue contrast
imaging with and without contrast agents (39 μm voxels)
Gated cardiac images of a mouse
Courtesy of Ottawa Heart Institute and
MDS-Nordion
Respiratory-gated lung images of a mouse
99m
Tc-Colloid Particles
Courtesy: Lovelace Respiratory
Research Institute
True Quantification Capabilities for
accurate Biodistribution studies
Iomeron™ 300 contrast agent. Courtesy: F. Van Leeuwen, NCI, Amsterdam
High-contrast SPECT/CT in both
xenograft and spontaneous tumor models
Radiofolate uptake in KB tumor
xenografts and kidneys: Courtesy:
C. Muller, PSI, Villigen
111In-Octreoscan uptake in smallcell lung cancer tumor:
Courtesy: J. Jonkers, NKI, Amsterdam
Due to the uniform resolution and sensitivity across the entire field-ofview, quantification is highly accurate. Multiple studies have proven that
quantification results correlate well with ex vivo results from gamma counters and
autoradiography.
Courtesy of Earsmus MC
Fast Dynamic and Kinetic SPECT (4D-SPECT)
The high-spatial and -temporal resolution of NanoSPECT/CT enables dynamic imaging with time resolutions
commensurate with SPECT tracer kinetics. With its proprietary helical MMP-SPECT technology, whole-body
images can be acquired in a couple of minutes, while focused imaging enables to perform uptake studies in organs
and tumors at sub-min intervals and with sub-mm isotropic resolution.
NanoSPECT/CT®
Flexible and easy to operate
Easily exchangeable
Multi-pinhole aperture plates
Pathogen-free, plug-in animal cells*
Proprietary plug-in animal chambers with sizes from mice to rabbits, including
temperature and anesthetic gas control. The imaging cells can be enclosed to
avoids exposure of users and animals to pathogens. Unique quick-connects with
double-sealing protection enables using multiple cells in parallel to optimize
work flow. Compatible with PET, SPECT, CT and MRI systems.
NanoSPECT/CT meets all your research requirements.
Change your apertures with a simple slide-out, slide-in
operation to maximize perfomance for your particular
application.
(*see dedicated brochure for more information)
Exchanging Multi-pinhole apertures.
Workstation with InVivoScope software™*
The InVivoScope-based multi-modality image-processing workstation supports
the import and export of DICOM data, from up to three modalities including
SPECT, CT, PET and MR. Images can be co-registered, fused, analyzed and
exported into various image and movie formats. All display modes, from
orthogonal views, slice views, to special co-registration multi-views as well as
3D MIP and volume renderings are available. Built-in tools for quantification,
distance and size measurements, re-orientation and rigid transformations as
well as cropping allow extracting information with minimal effort. Acquired
data can be exported into spreadsheet-ready format.
Inserting collimators for planar & large animal imaging.
For true translational imaging, NanoSPECT can image
animals - small and large - with a full-ring of highresolution detectors and a bore size of up to 20 cm.
Touch screen for acquisition setup
CT and SPECT detectors are fieldupgradeable
At any time, NanoSPECT can be
upgraded with up to 4 detectors, new
multi-pinhole aperture plates and
with X-Ray CT. These upgrades can be
performed on site.
Dimensions and Physical data:
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162x145x145 cm3; minimum room size: 2.85x3.15 m2
Recommended temperature range: 18-24°C;
Relative humidity: 40 to 80%, non-condensing
Heat dissipation: max 3300 BTU/hr
Power: 110-240VAC; max. 1000VA
System weight: approx. 800 kg; Floor loading: total weight
distributed over built-in fourfooted stand: 180-220 kg
per foot. Pressure in weight distribution pads: 0.8 kg/cm2
(80kPa).
Radiopharmaceutical
Quality Control Systems
“The Gold Standard”
Automated PET Synthesis Systems
“Taking PET Chemistry Beyond FDG”
RevFC/SVC/YH/VT-0021709
“Setting New Performance Standards in Preclinical PET, SPECT and CT”
Molecular Imaging Solutions
Bioscan, Inc.
Toll-free: 1-800-255-7226
[email protected]
Bioscan Europe, Ltd.
Tel: +33 3 83 63 62 67
[email protected]
www.bioscan.com
www.spect-ct.com