Scientific Program - Society for Free Radical Research International

Scientific Program - Society for Free Radical Research International

Scientific Program (Satellite Symposium)
March 23 (Sunday)
Underline: Presenting Author
Room A
Satellite Symposium 1: The 8th Forum of Innovation Center for Medical Redox Navigation,
12:30-16:00
Kyushu University - Biomedical Innovation by “Redox Navigation”
Plenary Lecture
12:35-13:25
Chair: Hideo Utsumi, Japan
SS1-PL
Tocotrienol against stroke
Chandan K. Sen
Dept. of Surg., Davis Heart and Lung Res. Inst., The Ohio State Univ. Wexner Med. Cent., USA
Young Investigation Presentation
13:35-14:35
Chair: Toyoshi Inoguchi, Japan
SS1-Y1
Oxidative stress in schizophrenia: Clarifying the underlying mechanisms using ReMI
Takahiro A. Kato
Dept. of Neuropsychiatry, Grad. Sch. of Med. Sci., Kyushu Univ., Japan
SS1-Y2
Development and application of redox molecular imaging
Fuminori Hyodo
Innovation Cent. for Med. Redox Navigation., Kyushu Univ., Japan
SS1-Y3
Technology for imaging redox-related diseases in vivo
Kazuhiro Ichikawa
Innovation Cent. for Med. Redox Navigation, Kyushu Univ‌‌‌., Japan
22
SFRRI 2014
Room B2
Satellite Symposium
Mar. 23 (Sun)
Satellite Symposium 2: IRN2014 Kyoto related to Act Kyoto Redox TRX Translational
Res Center - Health & Skincare / Medicare / Agingcare -
10:30-16:00
Opening Introductory Remarks
Junji Yodoi, Japan
SS2-1
Mammalian thioredoxin reductase 1 in cellular signaling pathways
Elias S.J. Arnér
Div. of Biochem., Dept. of Med. Biochem. and Biophys., Karolinska Inst., Sweden
SS2-2
Proinflammatory functions of extracellular Peroxiredoxin 1: A case in ozone induced acute lung inflammation in mice
Tetsuro Ishii1, Eiji Warabi1, Toru Yanagawa1, Rie Yanagisawa2
1
Fac. of Med., Univ. of Tsukuba, Japan, 2Cent. for Environ. Health Sci., Natl. Inst. for Environ. Stu., Japan
SS2-3
Thioredoxin-1 (Trx-1) - mediated regulation of survival signaling: Intracellular compartmentalization and interactions
with Thioredoxin-interacting protein (Txnip)
Hugo P. Monteiro1, Fernando T. Ogata1, Roberto J. Arai2, Wagner L. Batista3, Adriano Sartori1, Hiroshi Masutani4, Junji
Yodoi4, Arnold Stern5
1
Dept. de Bioquímica, Universidade Federal de São Paulo, S.Paulo, Brazil, 2Inst. do Câncer do Est. de São Paulo, FMUSP, S.
Paulo, Brazil, 3Dept. de Ciências Biológicas, Universidade Federal de São Paulo, Diadema, S.Paulo, Brazil, 4Dept. of Biol.
Responses, Kyoto Univ., Kyoto, Japan, 5Dept. of Pharmacol., NYU Sch. of Med., NY, USA
SS2-4
TBD
Chandan K. Sen
Dept. of Surg., Davis Heart and Lung Res. Inst., The Ohio State Univ. Wexner Med. Cent., USA
Short Talk
Arne Holmgren, Sweden
Sue-Goo Rhee, Korea
Kazuichi Okazaki, Japan
Hiroshi Masutani, Japan
Junji Yodoi, Japan
Tian Haih, Japan
Kiichi Hirota, Japan
SFRRI 2014
23
Scientific Program (Satellite Symposium)
Room C1
Satellite Symposium 3: The 32nd Annual Meeting of Japanese Society for
Cytoprotection & Cytobiology
10:25-15:45
Opening Address
10:25-10:30
Chair: Hideyuki Majima, Japan
General Session 1
10:30-11:15
SS3-1
0 cells are susceptible to X-irradiation
Hiroko P Indo1, Chizuru Tsuruoka2, Shizuko Kakinuma2, Masao Suzuki2, Ken-ichiro Matsumoto2, Ikuo Nakanishi2,
Hsiu-Chuan Yen3, Hirofumi Matsui4, Toshihiko Ozawa5, Hideyuki J Majima1,6
1
Dept. Oncol. and Dept. Space Environ. Med., Kagoshima Univ. Grad. Sch. Med. Dent. Sci., Japan, 2Natl. Inst. of Radiolog.
Sci., Japan, 3Dept. Med. Biotechnol. Lab. Sci., Chang Gung Univ., Taiwan, 4Div. Gastroent., Grad. Sch. Comprehensive
Human Sci., Univ. of Tsukuba, Japan, 5Dept. Health Pharm., Yokohama Coll. Pharm., Japan
SS3-2
The deficiency of histidine enhances the delay of wound healing caused by indomethacin through the mitochondrial
dysfunction
Hiroshi Ichikawa1, Yukiko Minamiyama2, Mayuko Oka2, Tatsunobu Matsui2, Tomohisa Takagi3, Yuji Naito3, Toshikazu
Yoshikawa3
1
Grad. Sch. Life and Med. Sci., Doshisha Univ., Japan, 2Food Hygiene and Environ. Health, Div. of Appl. Life Sci., Grad.
Sch. Life and Environ. Sci., Kyoto Pref. Univ., Japan, 3Mol. Gastroent. Hepatol., Grad. Sch. Med. Sci., Kyoto Pref. Univ.
Med., Japan
SS3-3
Redox properties of a water-soluble cyclic selenide and its application as a glutathione peroxidase mimic
Michio Iwaoka1, K. Indira Priyadarsini2
1
Dept. Chem., Sch. Sci., Tokai Univ., Japan, 2Rad. Photochem. Div., Bhabha Atomic Res. Cent., India
General Session 2
11:15-12:00
SS3-4
Morphological and molecular components of tolerance to complete desiccation in the cells of an anhydrobiotic insect
Oleg Gusev1,2,3, Valdimir Evtugyn1, Elena Shagimardanova1, Jun Okada2, Takashi Okuda2, Takahiro Kikawada2
1
Inst. of Fund. Biol. and Med., Kazan Fed. Univ., Russia, 2Natl. Inst. of Agrobiol. Sci., Japan, 3JAXA, ISAS, Japan
SS3-5
Gastric cancer chemoprevention by phenethyl isothiocyanate-containing diet in chemically - but not genetically induced gastric cancer in mice
Anders Øverby1,2, Chun-Mei Zhao2, Atle Magnar Bones1, Duan Chen2
1
Dept. of Biol., Norwegian Univ. of Sci. and Technol., Norway, 2Dept. of Cancer Res. and Mol. Med., Norwegian Univ. of
Sci. and Technol., Norway
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SFRRI 2014
Luncheon Seminar
Satellite Symposium
Mar. 23 (Sun)
SS3-6
Oligosaccharides from agar ameliorate intestinal inflammation through the induction of heme oxygenase-1 expression
in macrophages
Yasuki Higashimura1,2, Yuji Naito1, Tomohisa Takagi1, Katsura Mizushima1, Hiromu Ohnogi2,3, Toshikazu Yoshikawa2
1
Mol. Gastroent. and Hepatol., Grad. Sch. Med. Sci., Kyoto Pref. Univ. Med., Japan, 2Dept. Food Factor Sci., Kyoto Pref.
Univ. Med., Japan, 3Takara Bio Inc., Japan
12:00-13:00
SS3-L
Molecular mechanism in the pathogenesis of the colitis-associated colorectal cancer
Kiichiro Tsuchiya1, Mamoru Watanabe2
1
Dept. of Adv. Therap. for Gastrointest. Dis., Grad. Sch. Tokyo Med. and Dent. Univ., Japan, 2Dept. of Gastroent. and
Hepatol., Grad. Sch. Tokyo Med. and Dent. Univ., Japan
Special Lectures
13:00-14:10
SS3-SL1
Pathomechanisms of Parkinson’s disease: Insights from the monogenic forms of Parkinson’s disease
Nobutaka Hattori
Dept. of Neurol., Juntendo Univ. Sch. of Med., Japan
SS3-SL2
Mitochondria are a novel target for prevention of the side effects of cancer therapy
Daret St. Clair
Basic Res. Markey Cancer Cent., Univ. of Kentucky, USA
Coffee Break
14:10-14:30
General Session 3
14:30-15:30
SS3-7
Carbon monoxide-releasing molecule attenuates intestinal ischemia-reperfusion injury in mice via up-regulation of
Nrf2/HO-1
Kazuhiro Katada1, Tomohisa Takagi1, Takaya Iida1, Katsura Mizushima1, Kazuhiro Kamada1, Kazuhiko Uchiyama1, Osamu
Handa1, Nobuaki Yagi1, Hiroshi Ichikawa2, Toshikazu Yoshikawa1, Yoshito Itoh1, Yuji Naito1
1
Dept. of Mol. Gastroent. and Hepatol., Grad. Sch. of Med. Sci., Kyoto Pref. Univ. of Med., Japan, 2Dept. of Med. Life Sys.,
Fac. of Life and Med. Sci., Doshisha Univ.
SS3-8
Rosuvastatin prevents liver tumorigenesis in high-fat diet-fed mice
Shinya Fukunishi, Keisuke Yokohama, Hideko Ohama, Tetsuya Sujishi, Yusuke Tsuchimoto, Akira Asai, Yasuhiro Tsuda,
Kazuhide Higuchi
2nd Dept. of Intern. Med., Osaka Med. Coll., Japan
SFRRI 2014
25
Scientific Program (Satellite Symposium)
SS3-9
Role of substance P and CGRP in gastric and hepatic MALT lymphoma induced by Helicobacter heilmannii infection
Masahiko Nakamura1, Hidenori Matsui2, Tetsufumi Takahashi1, Kanji Tsuchimoto1
1
Sch. of Pharm. Sci., Kitasato Univ., Japan, 2Kitasato Inst. for Life Sci., Kitasato Univ., Japan
SS3-10
Reduction of prostaglandin transporter is an independent predictor of poor prognosis in gastric adenocarcinoma
associated with tumor angiogenesis
Shogo Takeda, Tetsuya Tanigawa, Toshio Watanabe, Hirokazu Yamagami, Masatsugu Shiba, Kenji Watanabe, Kazunari
Tominaga, Yasuhiro Fujiwara, Kazuya Muguruma, Kosei Hirakawa, Tetsuo Arakawa
Dept. of Gastroent. and Surg. Oncol., Osaka City Univ. Grad. Sch. of Med., Japan
Closing Address
26
SFRRI 2014
15:30-15:45
Room C2
Satellite Symposium
Mar. 23 (Sun)
Satellite Symposium 4: Flavonoids: From Plants to Human Health
13:00-16:05
Chairs: Cesar G. Fraga, Argentina
Junji Terao, Japan
SS4-1
Plant flavonoid metabolism in humans
13:00-13:25
Alan Crozier1, Gina Borges1, Javier Ottaviani2, Tony Y Momma3, Justin van der Hooft1, Hagen Schroeter2
1
Sch. of Med., Univ. of Glasgow, UK, 2Mars, Inc., McLean, USA, 3Dept. of Nutr., Univ. of California Davis, USA
SS4-2
Molecular mechanisms behind flavanol health effects
Patricia I Oteiza
Dept. of Nutr. and Dept. of Environ. Toxicol., Univ. of California, Davis, USA
SS4-3
Flavonoids and vascular function and blood pressure
Kevin D. Croft
Sch. of Med. and Pharm., Univ. of Western Australia, Australia
SS4-4
Flavonoids and neuro-cognitive improvements:
The invovlement of the vascular system as a mediator of benefits
Jeremy P. E. Spencer
Dept. of Food and Nutr. Sci., Univ. of Reading, UK
SS4-5
Quercetin and metabolic syndrome
Masuko Kobori
Natl. Food Res. Inst., Natl. Agric. and Food Res. Org. (NARO), Japan
SS4-6
Isoflavones/equol and human health
Yoshiko Ishimi
Dept. of Food Function and Labeling, Natl. Inst. of Health and Nutr., Japan
SS4-7
Flavonoids: How far are we from dietary guidelines and evidence-based applications?
Hagen Schroeter
Mars Inc., USA
Closing Remarks
Helmut Sies
Heinrich-Heine-Univ. Dusseldolf, Germany
13:25-13:50
13:50-14:15
14:15-14:40
14:40-15:05
15:05-15:30
15:30-15:55
15:55-16:05
SFRRI 2014
27
Scientific Program
March 23 (Sunday)
Room A
Opening Ceremony
16:30-17:00
Chairs of SFRRI2014: Yuji Naito, Japan
Shinya Toyokuni, Japan
President of SFRRI: Michael Davies, Australia
Executive Advisors of SFRRI2014: Etsuo Niki, Japan
Toshikazu Yoshikawa, Japan
President of SFRR Japan (Host Society): Toshihiko Ozawa, Japan
Plenary Lecture 1
17:00-18:00
Chair: Etsuo Niki, Japan
Sponsored by SFRBM
PL1
Disentangling the effects of tyrosine nitration on protein structure and function
Rafael Radi
Dept. de Bioquímica and Cent. for Free Radical and Biomed. Res., Fac. de Med., Univ. de la República, Montevideo,
Uruguay
SFRRI Trevor Slater Award Lecture
18:00-18:50
Chair: Jose Vina, Spain
TSAL
The role of metabolic H2O2 generation: Redox signalling and oxidative stress
Helmut Sies
Inst. für Biochem. und Molekularbiologie I, Heinrich-Heine-Univ. Düsseldorf, Düsseldorf, Germany
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SFRRI 2014
March 24 (Monday)
Plenary Lecture 2
Mar. 23 (Sun)
Room A
8:30-9:30
Chair: Toshihiko Ozawa, Japan
PL2
Using stable free radicals to obtain unique and clinically useful data in vivo in human subjects
Harold Swartz
The Geisel Med. Sch. at Dartmouth, Hanover, NH, USA
9:30-9:40
Symposium 1: Redox-Active Iron in Disease Pathology and Treatment
9:40-11:40
Mar. 24 (Mon)
Break
Chairs: Shinya Toyokuni, Japan
Des Richardson, Australia
Sponsored by Informa Healthcare
S01-1
Intracellular transport and export of nitric oxide in cancer cells as dinitrosyl iron complexes via glutathione
S-transferase and MRP1
Des R. Richardson, Hiu Chuen Lok
Dept. of Pathol., Univ. of Sydney, Australia
S01-2
Cancer as a ferrotoxic disease
Shinya Toyokuni
Dept. of Pathol. Biol. Res., Nagoya Univ. Grad. Sch. of Med., Japan
S01-3
Increased redox-active iron induces mitochondrial damage that recruits Parkin
Kazuhiro Iwai
Dept. of Mol. & Cell. Physiol., Grad. Sch. of Med., Kyoto Univ., Japan
S01-4
The molecular and cellular effects of ascorbate on iron uptake from transferrin and intracellular iron trafficking in
neoplastic cells
Darius J R Lane, Sherin Chikhani, Vera Richardson, Des R. Richardson
Mol. Pharmacol. and Pathol. Program, Dept. of Pathol. and Bosch Inst., Univ. of Sydney, Australia
S01-5
Targeting lysosomal P-gp in cancer cells using redox active iron chelators
Patric J. Jansson, Tetsuo Yamagishi, Akanksha Arwind, Des R. Richardson
Dept. of Pathol. and Bosch Inst., Univ. of Sydney, Australia
Break
11:40-11:50
SFRRI 2014
29
Scientific Program
Meet the Professor 1
11:50-12:50
Chair: Yoshio Sumida, Japan
Sponsored by Astareal Co., Ltd
MP1
Astaxanthin and lipotoxicity-induced NASH
Tsuguhito Ota
Brain/Liver Interface Med. Res. Cent., Kanazawa Univ., Kanazawa, Japan
Break
12:50-13:00
Symposium 2: Oxidative Damage of Proteins/Amino Acids and its Consequences
13:00-15:00
Chairs: Michael J. Davies, Australia
Jan M. Gebicki, Australia
S02-1
Rates, mechanisms and consequences of protein modification: the importance of quantitative data
Michael J Davies
The Heart Res. Inst., Australia
S02-2
Thiyl radicals of protein cysteine residues: selective generation and catalytic potential in protein modification,
aggregation and fragmentation
Christian Schoneich
Dept. of Pharm. Chem., Univ. of Kansas, USA
S02-3
Electron-induced formation of glutathione peroxides
Janusz M. Gebicki
Dept. of Biol. Sci., Macquarie Univ., Australia
S02-4
Cysteine oxidation in ROS signalling
Philip Eaton
King’s Coll. London, UK
Coffee Break
15:00-15:20
Symposium 3: Oxidation of DNA/RNA and Signaling by Poly(ADP-ribosyl)ation
15:20-17:20
Chairs: Clare L. Hawkins, Australia
Laszlo Virag, Hungary
S03-1
Chemical and biochemical methods to measure oxidatively generated lesions within isolated and cellular DNA
Jean Cadet1,2, J Richard Wagner2
1
Inst. Nanosci. and Cryogenie, CEA/Grenoble, France, 2Med. Univ. of Sherbrooke, Canada
30
SFRRI 2014
S03-2
Oxidative stress to RNA, a novel disease mechanism?
Henrik E. Poulsen, Simon Frost, Trine Henriksen, Robert Bouchel, Allan Weimann
Clinical Pharmacol. Lab Q7642, Bispebjerg Hosp., Univ. of Copenhagen, Denmark
S03-3
Poly(ADP-ribosyl)ation as a redox signaling mechanism
Laszlo Virag1,2, Agnieszka Robaszkiewicz1,4, Zsuzsanna Valko1, Katalin Kovacs2, Eva Szabo3, Peter Bay1,2
1
Dept. of Med. Chem., Med. and Health Sci. Cent., Univ. Debrecen, Hungary, 2Cell Biol. and Signaling Res. Group of the
Hungarian Academy of Sci., Debrecen, Hungary, 3Dept. of Dermatol., Med. and Health Sci. Cent., Univ. of Debrecen,
Hungary, 4Inst. of Veterinary Biochem. and Mol. Biol., Univ. of Zurich, Switzerland
Mar. 24 (Mon)
S03-4
Role of PARP1 in the regulation of mitochondrial function in health and in critical illness
Csaba Szabo
Dept. of Anesthesiol., Univ. of Texas Med. Branch and Shriners Burns Hosp. for Children, USA
Evening Lecture 1
17:20-18:00
Chair: Koji Uchida, Japan
EL1
Oxidized protein aggregates: Formation and pathophysiological role
Tilman Grune
Inst. of Nutr., Friedrich Schiller Univ., Jena, Germany
SFRRI 2014
31
Scientific Program
Room B1
Symposium 4: Oxidative Protein Folding and ER Stress
9:40-11:40
Chairs: Junichi Fujii, Japan
David Ron, UK
Sponsored by The Tokyo Biochemical Research Foundation
S04-1
Protein folding homeostasis in the Endoplasmic Reticulum
David Ron
Univ. of Cambridge, UK
S04-2
Structural and mechanistic basis of the protein disulfide bond formation network in mammalian cells
Kenji Inaba
Inst. Multidisc. Res., Tohoku Univ., Japan
S04-3
The cellular response to hyperoxidizing conditions in the endoplasmic reticulum
Lars Ellgaard1, Jonas D. Schmidt1, Cecilie L. Soltoft1, Thomas Ramming2, Henrik M. Geertz-Hansen3,
Agnieszka S. Juncker3, Christian Appenzeller-Herzog2, Henning G. Hansen1
1
Dept. of Biol., Univ. of Copenhagen, Denmark, 2Dept. of Pharm. Sci., Univ. of Basel, Switzerland, 3Cent. for Biol. Sequence
Analysis, Technical Univ. of Denmark, Denmark
S04-4
Roles of ER stress sensors in early embryonic development of medaka fish
Kazutoshi Mori
Dept. of Biophys., Grad. Sch. of Sci., Kyoto Univ., Japan
Break
11:40-11:50
Meet the Professor 2
11:50-12:50
Chair: Masayasu Inoue, Japan
Sponsored by Mitsubishi Tanabe Pharma Corporation
MP2
The role of oxidative stress in the pathogenesis of diabetic complications and the possible usefulness of anti-oxidative
therapy
Toyoshi Inoguchi
Innovation Cent. for Med. Redox Navigation, Kyushu Univ., Fukuoka, Japan
Break
32
SFRRI 2014
12:50-13:00
Symposium 5: Cutting-Edge Chemical Tools Accelerating Redox Biology and Medicine:
From Basic Chemistry to Medical Applications
13:00-15:00
Chairs: Hidehiko Nakagawa, Japan
Steven Bottle, Australia
S05-1
Fluorescent probes for reversible, transient, and dynamic imaging of ROS in living cells
Bo Tang
Coll. of Chem., Chem. Eng. and Mater. Sci., Shandong Normal Univ., China
Mar. 24 (Mon)
S05-2
Design, synthesis and applications of fluorescent probes for molecular imaging of superoxide, peroxynitrite, and
hypochlorous acid
Dan Yang
Morningside Lab. for Chem. Biol., Dept. of Chem., The Univ. of Hong Kong, China
S05-3
Probing the radical-trapping reactivity of novel phenolic, aminic and organosulfur antioxidants using fluorescence
Derek A Pratt
Dept. of Chem., Univ. of Ottawa, Canada
S05-4
Rational design of fluorogenic and luminogenic probes for redox biology
Yasuteru Urano1,2
1
Grad. Sch. Med. and Pharm. Sci., The Univ. of Tokyo, Japan, 2Basic Res. Program, JST
Coffee Break
15:00-15:20
Oral 1: Redox Signaling
15:20-16:20
Chairs: Hiroshi Ichikawa, Japan
Toshihiko Osawa, Japan
O1
Upregulated cytoglobin in fibroblasts and myofibroblasts may contribute to healing of gastric mucosal injuries during
late healing phase
Fumio Tanaka1, Kazunari Tominaga1, Tetsuya Tanigawa1, Toshio Watanabe1, Yasuhiro Fujiwara1, Norifumi Kawada2,
Katsutoshi Yoshizato3, Tetsuo Arakawa1
1
Osaka City Univ., Grad. Sch. of Med., Dept. of Gastroenterol., Japan, 2Osaka City Univ., Grad. Sch. of Med., Dept. of
Hepatol., 3PhoenixBio Co., Ltd.
O2
Biochemical properties and functions of mitochondrial peroxiredoxin V
Ju Hyun Sim1, Jiyoung Park1, Su-in Jo2, Sei Yoon Chu3, Dongmin Kang2, Sue Goo Rhee3, Hyun Ae Woo1
1
Coll. of Pharm., Ewha Womans Univ., Korea, 2Dept. of Life Sci., Ewha Womans Univ., 3Yonsei Biomed. Res. Inst., Yonsei
Univ. Coll. of Med.
SFRRI 2014
33
Scientific Program
O3
The potential roles of PRDX4 as a thiol oxidase in endoplasmic reticulum
Toshihiro Kurahashi1, Jaeyong Lee1, Atsunori Nabeshima2, Nobuyuki Shirasawa3, Sohsuke Yamada2, Toshifumi Takao4,
Junichi Fujii1
1
Dept. of Biochem. and Mol. Biol., Grad. Sch. of Med. Sci., Yamagata Univ., Japan, 2Dept. of Pathol. and Cell Biol., Sch. of
Med., Univ. of Occup. and Environ. Health, 3Dept. of Anat. and Struct. Sci., Sch of Med., Yamagata Univ., 4Inst. for Protein
Res., Osaka Univ.
O4
Scavenging and quenching effects of melanin on ROS and other reactive species
Mika Tada1, Masaki Kobayashi2, Shigenobu Kasai3, Masahiro Kohno4, Yoshimi Niwano5
1
Cent. of General Education, Tohoku Inst. of Technol., Japan, 2Grad. Dept. of Electronics, Tohoku Inst. of Technol., 3Grad.
Dept. of Env. Information Eng., Tohoku Inst. of Technol., 4Grad. Sch. of Biosci. and Biotechnol., Tokyo Inst. of Technol.,
5
Grad. Sch. of Dent., Tohoku Univ.
O5
Thioredoxin related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
Irina Pader, Rajib Sengupta, Marcus Cebula, Jianqiang Xu, Arne Holmgren, Katarina Johansson, Elias S.J. Arner
Div. of Biochem., Dept. of Med. Biochem. and Biophys., Karolinska Inst., Sweden
Oral 2: Cancer 1
16:20-17:08
Chairs: Hideyuki Majima, Japan
Young-Joon Surh, Korea
O6
PI3Ks regulate the cystine/glutamate antiporter system xc- via eIF2alpha phosphorylation and ATF4 - a pathway active
in glioblastomas and epilepsy
Jan Lewerenz1, Paul Baxter2, Rebecca Kassubek1, Philipp Albrecht3, Joeri Van Liefferinge4, Ilse Smolders4, Axel Methner3,
Ann Massie4, Giles E Hardingham2, Pamela Maher5
1
Dept. of Neurol., Ulm Univ., Germany, 2Cent. for Integrative Physiol., Univ. of Edinburgh, 3Dept. of Neurol., Heinrich-HeineUniv., Duesseldorf, 4Cent. for Neurosci., Vrije Univ. Brussel, 5Cellular Neurobiol. Lab., Salk Inst. for Biol. Studies
O7
The role of Nrf2 in oxidative stress induced ovarian carcinogenesis
Monique GP van der Wijst1, Christian Huisman1, Gerard Roelfes2, Marianne G Rots1
1
Epigenetic Editing, Dept. of Pathol. and Med. Biol., Univ. Med. Cent. Groningen, Univ. of Groningen, The Netherlands,
2
Stratingh Inst. for Chem., Univ. of Groningen, The Netherlands
O8
Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress
mechanism
Sawako Miyoshi1, Hidekazu Suzuki1, Hitoshi Tsugawa1, Tatsuhiro Masaoka1, Juntaro Matsuzaki1, Seiichiro Fukuhara1,
Kenro Hirata2, Hideki Mori1, Takanori Kanai1, Hideyuki Saya3
1
Div. of Gastroentrol. and Hepatol., Dept. of Intern. Med., Keio Univ. Sch. of Med., Japan, 2Dept. of Gastroenterol.,
Saiseikai Utsunomiya Hosp., 3Inst. for Advanced Med. Res., Keio Univ. Sch. of Med.
O9
A novel drug delivery system consisting of an antitumor agent tocopheryl succinate
Kentaro Kogure1, Satoru Utsumi1, Yuki Fukuda1, Kayoko Nakayama1, Yuriko Okamura1, Susumu Hama1, Kenji Fukuzawa2
1
Dept. of Biophys. Chem., Kyoto Pharm. Univ., Japan, 2Fac. of Pharm., Yasuda Women’s Univ.
34
SFRRI 2014
Room B2
Morning School for Beginners 1:
7:30-8:20
Chair: Hirofumi Matsui, Japan
Sponsored by CCFR
What is oxidative stress
Shinya Toyokuni
Dept. of Pathol., Nagoya Univ. Grad. Sch. of Med.., Japan
Symposium 6: Free Radicals, Radiation, Hormesis and Health
Mar. 24 (Mon)
Antioxidant system
Junichi Fujii
Dept. of Biochem. and Mol. Biol., Grad. Sch. of Med. Sci., Yamagata Univ., Japan‌‌‌
9:40-11:40
Chairs: William H. McBride, USA
Kazunori Anzai, Japan
S06-1
Pro- and anti-oxidant forces in low dose radiation responses
Bill McBride
Div. of Mol. and Cellular Oncol., Dept. of Radiation Oncol., and Pasarow Mass Spectrometry Lab., David Geffen Sch. of
Med. at Univ. of California, Los Angeles, USA
S06-2
Radiation-induced non-targeted effects: Transmission of genetic change mediated by oxidative stress?
Carmel E Mothersill, Colin B Seymour
Dept. of Med. Phys. and Appl. Radiation Sci., McMaster Univ., Canada
S06-3
Low dose diagnostic CT radiation increases lifespan and decreases cancer risk in cancer prone mice
Douglas R Boreham
Northern Ontario Sch. of Med. and Bruce Power, Canada
S06-4
Dietary inducers of an adaptive stress response
Marc Birringer
Dept. of Nutr. Food and Cons. Sci., Fulda Univ. of Appl. Sci., Germany
Break
11:40-11:50
Meet the Professor 3
11:50-12:50
Chair: Shinya Toyokuni, Japan
MP3
Challenge for plasma medical science and innovations
Masaru Hori
Plasma Med. Sci. Global Innovation Cent., Nagoya Univ., Nagoya, Japan
SFRRI 2014
35
Scientific Program
Break
12:50-13:00
Symposium 7: Antioxidants: Chemistry meets Epidemiology
13:00-15:00
Chairs: Maret Traber, USA
Etsuo Niki, Japan
S07-1
Role of antioxidants against ROS/RNS
Etsuo Niki
Kyoto Pref. Univ. of Med. and Natl. Inst. of Advanced Ind. Sci. & Technol., Japan
S07-2
Nucleophilic tone: a new paradigm for the action of nutritional antioxidants
Henry J Forman1,2, Kelvin J Davies1, Fulvio Ursini3
1
Davis Sch. of Gerontol., Univ. of Southern California, USA, 2Life and Env. Sci., Univ. of California, Merced, 3Univ. of
Padova, Italy
S07-3
Is redox signaling necessarily linked to an oxidative stress?
Fulvio Ursini
Dept. of Mol. Med., Univ. of Padova, Italy
S07-4
Epidemiological, experimental and clinical vitamin E research
Maret G. Traber
Linus Pauling Inst., Oregon State Univ., USA
Coffee Break
15:00-15:20
Oral 3: Novel Therapy
15:20-16:20
Chairs: Ken-ichi Yamada, Japan
Hyeyoung Kim, Korea
O10
Modulating myeloperoxidase-induced endothelial damage by a carbon monoxide-releasing molecule, CORM-3
Eric K. Patterson1, Alfredo Capretta2, Douglas D. Fraser1, Richard F. Potter1, Gediminas Cepinskas1
1
Cent. for Critical Illness Res., Lawson Health Res. Inst., Canada, 2Dept. of Chem., McMaster Univ., Hamilton, Canada
O11
Nrf2 mediates the protective effect of mood stabilizer lithium against oxidative stress
Jun-Feng Wang1,2, Joshua Rizak2, Hua Tan1
1
Dept. of Pharmacol. and Therap., Univ. of Manitoba, Canada, 2Dept. of Psychiatry, Univ. of British Columbia
O12
Mechanistic studies of brain endothelial dysfunction in diabetic stroke
Ziyan Zhang, Honglian Shi
Dept. of Pharm. and Toxicol., Univ Kansas, USA
36
SFRRI 2014
O13
Attenuation of monoamine oxidase-A activity and its expression level in the brain as possible mechanisms of
antidepressant-like action of flavonoids
Yauhen Bandaruk, Rie Mukai, Junji Terao
Grad. Sch. of Nutr. and Biosci., the Univ. of Tokushima, Japan
O14
Protective effect of mitochondria-targeted nano-antioxidants on the hypoxia induced oxidative stress and apoptosis
Yang Liu, Saipeng Huang, Libo Du
Inst. of Chem., the Chinese Academy of Sci., China
16:20-17:08
Mar. 24 (Mon)
Oral 4: Cardiovascular 1
Chairs: Corinne Spickett, UK
Daniela Caporossi, Italy
O15
Glutaredoxin 2 regulates vascular development by reversible glutathionylation of sirtuin 1
Lars Braeutigam1, Lasse D.E. Jensen2, Gereon Poschmann3, Klaudia Lepka4, Sergio J. Montano1, Orhan Aktas4,
Kai Stuehler3, Yihai Cao2, Arne Holmgren1, Carsten Berndt1,4
1
Dept. of Med. Biochem. and Biophys., Karolinska Inst., Sweden, 2Dept. of Mol. Tumor and Cell Biol., Karolinska Inst.,
Stockholm, Sweden, 3Mol. Proteomics Lab., BMFZ, Heinrich-Heine-Univ., Duesseldorf, Germany, 4Neurol., HeinrichHeine-Univ., Duesseldorf, Germany
O16
Cardiomyopathy in a mouse cardiac model of Friedreich’s ataxia involves the activation of the integrated stress response
Michael L.H. Huang1, Sutharshani Sivagurunathan1, Samantha Ting1, Patric J Jansson1, Christopher J.D. Austin1,
Matthew Kelly2,3, Christopher Semsarian2,3, Daohai Zhang1, Des R. Richardson1
1
Dept. of Pathol., Univ. of Sydney, Australia, 2Centenary Inst., Sydney, Australia, 3Dept. of Cardiol., Royal Prince Alfred
Hosp., Sydney, Australia
O17
PKG1alpha is a novel molecular target of HNO in the cardiovascular system
Sonia Donzelli1, Oleksandra Prysyazhna2, Konstantina Stathopoulou1, Volkan Polat1, Philip Eaton2, Friederike Cuello1
1
Dept. of Experimental Pharmacol. and Toxikol., Univ. Med. Cent. Hamburg-Eppendorf, Germany, 2BHF Cent., King`s Coll.
London, UK
SFRRI 2014
37
Scientific Program
Room K
Oral 5: Oxidative Signaling
15:20-16:20
Chairs: Masayasu Inoue, Japan
Lars Ellgaard, Denmark
O18
Inducible nitric oxide synthase and ER stress-mediated apoptosis is decreased by sphingomyelinase inhibition in retinal
pigment epithelial cells
Mutay Aslan1, Ertan Kucuksayan1, Esma K. Konuk2, Nejdet Demir2, Bulent Mutus3
1
Dept. of Biochem., Akdeniz Univ. Med. Fac., Turkey, 2Dept. of Histol., Akdeniz Univ. Med. Fac., 3Dept. of Chem. and
Biochem., Univ. of Windsor, Ontario, Canada
O19
Reaction of lipid peroxyl radicals with transmembrane peptides: Mechanistic and structural aspects of tyrosine
oxidation
Silvina Bartesaghi1, Ariel Petruk2, Daniel Herrera1, Ari Zeida2, Marcelo Marti2, Dario Estrin2, Rafael Radi1
1
Dept. de Bioquimica, Cent. for Free Radical and Biomed. Res., Fac. de Med., Uruguay, 2INQUIMAE, Fac. de Ciencias
Exactas y Naturales, Univ. de Buenos Aires, Argentina
O20
A tracer analysis to demonstrate the role of endogenous CO as a systemic signal transmitter to suppress ROS induced
cell injury
Makoto Sawano1,2, Akito Shimouchi2, Tomoe Mizukami2
1
Dept. of Emergency Med. and Critical Care, Saitama Med. Cent., Saitama Med. Univ., Japan, 2Dept. of Cardiac Physiol., Natl.
Cerebral and Cardiovascular Res. Cent.
O21
Treatment of myofibroblast with CO enhances colonic epithelial cell restitution via inhibition of microRNA-710 and
increase of FGF15 expression
Kazuhiko Uchiyama, Yuji Naito, Tomohisa Takagi, Katsura Mizushima, Tetsuya Okayama, Kazuhiro Katada,
Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Nobuaki Yagi, Toshikazu Yoshikawa, Yoshito Itoh
Mol. Gastroenterol. and Hepatol., Kyoto Pref. Univ. of Med., Japan
O22
Liver regeneration therapy for liver cirrhosis using cultured bone marrow-derived mesenchymal stem cells with
stabilization of redox homeostasis
Taro Takami, Shuji Terai, Isao Sakaida
Dept. of Gastroenterol. and Hepatol., Yamaguchi Univ. Grad. Sch. of Med., Japan
Oral 6: Lipids
16:20-17:08
Chairs: Pierre Leroy, France
Sue Goo Rhee, Korea
O23
Biological activities of 7-dehydrocholesterol-derived oxysterols in cells
Libin Xu1, Zeljka Korade2, Karoly Mirnics2, Ned A Porter1
1
Dept. of Chem. and Vanderbilt Inst. of Chem. Biol., Vanderbilt Univ., USA, 2Dept. of Psyc. and Vanderbilt Kennedy Cent.,
Vanderbilt Univ.
38
SFRRI 2014
O24
Mitochondrial impairment and oxidative stress in the pathogenesis of steatohepatitis: an issue of lipid quality
Francesco Bellanti, Rosanna Tamborra, Giuseppina Iannelli, Maria Blonda, Domenica Mitarotonda, Gianluigi Vendemiale,
Gaetano Serviddio
Dept. of Med. and Surg. Sci., Univ. of Foggia, Italy
Mar. 24 (Mon)
O25
Analysis of photoreactivity of human retinal lipid extracts of different age groups
Anna M Pawlak1, Agnieszka Broniec1, Andrzej Zadlo1, Mariusz Duda1, Olivier Berdeaux2, Stephane Gregoire2,
Lionel Bretillon2, Tadeusz Sarna1
1
Dept. of Biophys., Fac. of Biochem. Bioph. and Biotechnol., Jagiellonian Univ., Poland, 2INRA, Univ. de Bourgogne, Dijon,
France
O26
Prosaposin regulates coenzyme Q10 levels in HepG2 cells especially those in mitochondria
Misato Kashiba, Mikiko Oizumi, Masaru Suzuki, Yoshimi Sawamura, Kohei Nagashima, Hiroshi Moriuchi,
Shinichi Yoshimura, Yorihiro Yamamoto
Tokyo Univ. of Technol., Japan
SFRRI 2014
39
Scientific Program
March 25 (Tuesday)
Room A
Plenary Lecture 3
8:30-9:30
Chair: Michael J. Davies, Australia
PL3
NADPH oxidases in Neutrophil Extracellular Traps
Arturo Zychlinsky
Dept. of Cell. Microbiol. at the Max Planck Inst. for Infect. Biol., Berlin, Germany
Break
9:30-9:40
Symposium 8: Redox-Based Regulation of Cellular Processes
9:40-11:40
Chairs: Junji Yodoi, Japan
Arne Holmgren, Sweden
S08-1
Thioredoxin and glutaredoxin systems in DNA synthesis and control
Arne Holmgren
Dept. of Med. Biochem. and Biophys., Karolinska Inst., Sweden
S08-2
Hyperoxidation of peroxiredoxin and circadian rhythm
Sue-Goo Rhee, In Sup Kil
Yonsei Biomed. Res. Inst., Yonsei Univ. Coll. of Med., Korea
S08-3
Compartmentation of thiol-redox control in the eukaryotic cell
Michel B. Toledano1, Joelle Vinh2, Giovanni Chiappetta2, Shakir Shakir2, Agnes Delaunay-Moisan1, Alise Ponsero1,
Aeid Igbaria1, Samia Miled1
1
CEA/IBITECS/LSOC, CEA-Saclay France, France, 2SMBP CNRS USR3149
S08-4
Redox modulation of pro-inflammatory and anti-inflammatory signaling
Young-Joon Surh
Coll. of Pharm., Seoul Natl. Univ., Korea
S08-5
Development of redox modulating approaches against cancer and diabetes by Thioredoxin binding protein-2 (TBP-2)/
Txnip
Hiroshi Masutani, Cristiane Lumi Hirata
Inst. for Virus Res., Kyoto Univ., Japan
Break
40
SFRRI 2014
11:40-11:50
Meet the Professor 4
11:50-12:50
Chair: Jiri Neuzil, Australia
Sponsored by Otsuka Pharmaceutical Co., Ltd.
MP4-1
Gastric agressive factors are oxidative stressors
Hirofumi Matsui
Fac. of Med., Univ. of Tsukuba, Tsukuba, Japan
MP4-2
Rancid radical talk: Music of mitochondrial cardiolipins
Valerian E. Kagan
Cent. for Free Radical and Antioxidant Health, Dept. of Environ. Health, Univ. of Pittsburgh, Pittsburgh, USA
Break
12:50-13:00
Symposium 9: Modulation of Oxidative Processes by Gaseous Molecules
13:00-15:00
Chairs: Takaaki Akaike, Japan
Gediminas Cepinskas, Canada
Sponsored by ERATO SUEMATSU Gas Biology Project
Mar. 25 (Tue)
S09-1
Formation and regulation of electrophilic signaling mediated by 8-nitro-cGMP
Takaaki Akaike
Dept. of Environ. Health Sci. and Mol. Toxicol., Tohoku Univ. Grad. Sch. Med., Japan
S09-2
Bacterial sensing by macrophages through carbon monoxide-dependent inflammasome activation
Leo E. Otterbein1, Barbara Wegiel1, Rasmus Larsen2, David Gallo1, Beek Yoke Chin1, Patty Lee4, Praveen Mannam4,
Brian S Zuckerbraun3, Richard Flavell4, Miguel Soares2
1
Beth Israel Deaconess Med. Cent./Harvard Med. Sch., USA, 2Gulbenkian Inst., 3Univ. of Pittsburgh, 4Yale Univ. Sch. of
Med.
S09-3
Redox biology of hydrogen sulfide
Jon M Fukuto, Katsuhiko Ono, Henry Le
Dept. of Chem., Sonoma State Univ., USA
S09-4
Inhibition of vascular smooth muscle cell proliferation by truncated heme oxygenase-1
Roland Stocker, Jun Ni, Magda Lam, Ghassan Maghzal
Victor Chang Cardiac Res. Inst., Australia
S09-5
PFKFB3 demethylation regulates CO/CBS-dependent directional glucose biotransformation to pentose phosphate
pathway as an anti-oxidative mechanism for cancer cell survival and chemoresistance
Makoto Suematsu1,2, Takehiro Yamamoto1, Kyoko Ishiwata1, Mitsuyo Ohmura1, Akiko Kubo1, Takako Hishiki1
1
Dept. of Biochem., Sch. of Med., Keio Univ., Japan, 2JST ERATO Suematsu Gas Biol. Project
SFRRI 2014
41
Scientific Program
Coffee Break
15:00-15:20
Symposium 10: Nrf2 – A Regulator of Redox Signaling and Antioxidant Defenses in
Health and Disease
15:20-17:20
Chairs: Giovanni E. Mann, UK
Henry Forman, USA
Sponsored by SFRBM
S10-1
Keap1-Nrf2 regulatory system in health and diseases
Masayuki Yamamoto, Takafumi Suzuki, Toshiaki Fukutomi, Yoko Yagishita, Akira Uruno
Dept. of Med. Biochem., Tohoku Univ. Grad. Sch. of Med., Japan
S10-2
The Nrf2 regulatory network: a gatekeeper against oxidative and electrophile stress
John D. Hayes, Sudhir Chowdhry, Calum Sutherland
Med. Res. Inst., Ninewells Hosp. and Med. Sch., Univ. of Dundee, Scotland, UK
S10-3
Keap1-Nrf2 signaling: a target for cancer prevention by sulforaphane
Thomas W Kensler1, Patricia A Egner2, Alvaro Munoz2, John D Groopman2, Jed W Fahey2, Paul Talalay2,
Stephen S Hecht3, Tao-Yang Chen4, Jian-Guo Chen4
1
Dept. Pharmacol. and Chem. Biol., Univ. Pittsburgh, USA, 2Johns Hopkins Univ., Baltimore, USA, 3Univ. of Minnesota,
Minneapolois, USA, 4Qidong Liver Cancer Inst., Qidong, China
S10-4
In utero programing of impaired Nrf2 mediated redox signaling in fetal vascular cells
Giovanni E. Mann, Sarah J. Chapple, Xinghua Cheng, Bijal Patel, Richard C. Siow
BHF Cent. of Res. Excellence, Sch. of Med., King’s Coll. London, UK
Evening Lecture 2
17:20-18:00
Chair: Young-Joon Surh, Korea
Sponsored by SFRR Asia
EL2
Regulation of human mitochondrial function by Sirt3-mediated deacetylation of respiratory enzymes under oxidative
stress
Yau-Huei Wei1, Yu Ting Wu2
1
Dept. of Med., Mackay Med. Coll., New Taipei City, Taiwan, 2Dept. of Biochem. and Mol. Biol., Natl. Yang-Ming Univ.,
Taiwan
SFRRI Annual General Meeting
42
SFRRI 2014
18:00-19:00
Room B1
Symposium 11: Redox Molecular Imaging
9:40-11:40
Chairs: Kazuhiro Ichikawa, Japan
Howard J. Halpern, USA
S11-1
Biological application of EPR imaging of oxygen in tumors
Howard J. Halpern1,2, Boris Epel1,2, Martyna Elas1,2,3, Gage Redler1,2, Kay Macleod2, Nanduri Prabkahar2, Zvi Fuchs4,
Richard Kolesnick4, Ralph Weichselbaum1, Victor Tormyshev2,5
1
Dept. of Radiation and Cell. Oncol., Univ. of Chicago, USA, 2Cent. for Electron Paramagnetic Resonance Imaging In Vivo
Physiol., Univ. of Chicago, 3Fac. Bio-chem., Biophys. and Biotechnol., Jagiellonian Univ., Krakow, Poland, 4Memorial Sloan
Kettering Cancer Cent., New York, 5Novosibirsk Inst. of Organic Chem., Russia
S11-2
Measurement and mechanism of oxygen in myocardial tissue injury and protection
Periannan Kuppusamy
Geisel Sch. of Med., Dartmouth Coll., USA
Mar. 25 (Tue)
S11-3
Quantitative EPR oxygen imaging guided treatment in pancreatic cancer
Shingo Matsumoto1, Keita Saito1, Yoichi Takakusagi1, Masayuki Matsuo1, Jeeva P. Munasinghe2,
Nallathamby Devasahayam1, Sankaran Suburamanian1, James B. Mitchell1, Murali C. Krishna1
1
Radiation Biol. Branch, Natl. Cancer Inst., NIH, Bethesda, USA, 2Natl. Inst. of Neurol. Disorder and Stroke, NIH,
Bethesda, USA
S11-4
Development of redox molecular imaging of free radicals in living animal
Hideo Utsumi, Fuminori Hyodo1, Keiji Yasukawa2, Mayumi Yamato1, Shinji Ito1, Tatsuya Naganuma3, Kazuhiro Ichikawa1,
Ryoma Kobayashi1
1
Innovation Cent. for Med. Redox Navigation, Kyushu Univ., Japan, 2Fac. of Pharm. Sci., Kyushu Univ., 3Japan Redox Ltd.
Break
11:40-11:50
Meet the Professor 5
11:50-12:50
Chair: Kazunori Anzai, Japan
Sponsored by Japanese Society Alpha-Lipoic of Acid
MP5-1
Historical background and recent topics of lipoic acid research
Seiichi Matsugo1, Yoshiki Koriyama2, Osamu Hori3
1
Fac. of Nat. Sys., Inst. of Sci. and Eng., Kanazawa Univ., Kanazawa, Japan
2
Dept. of Mol. Neurobiol. and 3Dept. of Neuroanatomy, Grad. Sch. of Med., Kanazawa Univ., Kanazawa, Japan
SFRRI 2014
43
Scientific Program
MP5-2
Nutrition and healthy ageing—from calorie restriction to MediterrAsian diet and lipoic acid
Gerald Rimbach
Inst. of Human Nutr. and Food Sci., Univ. of Kiel, Kiel, Germany
Break
12:50-13:00
Symposium 12: The Yin and Yang of Redox Host Defense against Infection
13:00-15:00
Chairs: Lin L. Mantell, USA
Douglas Thomas, USA
S12-1
Redox regulation of community behavior in Pseudomonas aeruginosa
Lars E. P. Dietrich
Dept. of Biol. Sci., Columbia Univ., USA
S12-2
Nox and Duox family of NADPH oxidases in host defense and inflammatory responses to infection
Thomas L Leto, Howard E. Boudreau, Jaeyul Kwon, Devin J. Burke, Benjamin W. Casterline, Balazs Rada
Natl. Inst. of Allergy and Infect. Dis., Natl. Inst. of Health, USA
S12-3
The role of reactive oxygen species (ROS) in gastric carcinogenesis evoked by H. pylori infection
Hitoshi Tsugawa1,2, Hidekazu Suzuki1,2
1
Cent. for Integrated Med. Res., Keio Univ., Japan, 2Div. Gast. Hepatol., Dept. Int. Med., Keio Univ., Sch. of Med.
S12-4
HMGB1 mediates oxygen toxicity-compromised innate immunity in ventilator-associated pneumonia
Lin L Mantell1,2, Vivek Patel1, Ravikumar Sitapara1, Lokesh Sharma1, Kevin J Tracey2
1
Dept. of Pharm. Sci, St. John’s Univ., Coll. of Pharm. and Health Sci., NY, USA, 2The Feinstein Inst. for Med. Res., NS-LIJ
Health Sys., NY
Coffee Break
Oral 7: Free Radical Chemistry
15:00-15:20
15:20-16:08
Chairs: Keiichiro Suzuki, Japan
Jean Cadet, France
O27
Development for direct detection of OH radicals emanated from human skin using LIF technique
Dock-Chil Che1, Akito Shimouchi2, Tomoe Mizukami2, Kazutoshi Nose2
1
Dept. of Chem., Grad. Sch. of Sci., Osaka Univ., Japan, 2Dept. of Cardiac Physiol., Natl. Cerebral and Cardiovascular Res.
Cent.
O29
A novel role for endogenous bilirubin in protecting from adenine induced kidney damage
Connie Boon1, Vinod Gopalan2, Alfred Lam2, Jeff S Coombes3, Robert G Fassett3, Andrew C Bulmer1
1
Heart Found. Res. Cent., Griffith Health Inst., Griffith Univ., Australia, 2Sch. of Med., Dept. of Pathol., Griffith Univ.,
Australia, 3Sch. of Human Movement Studies, Univ. of Queensland, Australia
44
SFRRI 2014
O30
Hydroxyl radical-dependent chemiluminescence emission during advanced oxidation of haloaromatics
Ben-Zhan Zhu, Li Mao
Res. Cent. for Eco-Environ. Sci.; The Chinese Academy of Sci., China
Oral 8: Metabolic Syndrome
16:08-16:56
Chairs: Hiroto Kimura, Japan
Kimitaka Takitani, Japan
O31
Detection of S-(2-succinyl)cystein (2SC) in adipocytes and in serum by LC-MS/MS as a marker for adipocyte
metabolism
Ryoji Nagai, Jun-ichi Shirakawa, Masatoshi Shinagawa, Rei-ichi Ohno, Mime Nagai
Dept. of Biosci. Sch. of Agri., Tokai Univ., Japan
O32
New insights into metabolic regulation by protein-tyrosine phosphatase 1B
Fawaz Haj
Dept. of Nutr. and Intern. Med., Univ. of California Davis, USA
Mar. 25 (Tue)
O33
Lipid peroxidation in pancreatic beta-cells in diabetes: the sweet road from hormesis to disaster
Shlomo Sasson, Guy Cohen
Dept. of Pharmacol., Inst. for Drug Res., Fac. of Med., The Hebrew Univ. of Jerusalem, Israel
O34
Oxidative stress down-regulates sirt3-mediated deacetylation of respiratory enzymes
Yu Ting Wu1,2, Yau-Huei Wei1,2
1
Dept. of Med., Mackay Med. Coll., New Taipei City, Taiwan, 2Dept. of Biochem. and Mol. Biol., Natl. Yang-Ming Univ.,
Taipei
SFRRI 2014
45
Scientific Program
Room B2
Morning School for Beginners 2
7:30-8:20
Chair: Hirofumi Matsui, Japan
Sponsored by CCFR
Oxidative stress marker 1
Hiroshi Ichikawa
Fac. of Life and Med. Sci., Doshisha Univ., Japan
Oxidative stress marker 2
Hidehiko Nakagawa
Grad. Sch. of Pharm. Sci., Nagoya City Univ., Japan‌‌‌
Symposium 13: Redox Biology of Insulin and its Resistance
9:40-11:40
Chairs: Holger Steinbrenner, Germany
Enrique Cadenas, USA
S13-1
Interference of the micronutrient selenium with the insulin-regulated energy metabolism
Holger Steinbrenner
Inst. for Biochem. and Mol. Biol. I, Heinrich-Heine-Univ., Duesseldorf, Germany
S13-2
A novel role for selenoprotein P in the regulation of insulin sensitivity
Hirofumi Misu1, Yoshiro Saito2, Kazuhiko Takahashi3, Toshinari Takamura1, Shuichi Kaneko1
1
Dept. of Dis. Cont. and Homeost., Kanazawa Univ., Japan, 2Dept. of Med. Life Sys, Fac. of Med. and Life Sci., Doshisha
Univ., 3Dept. of Nutr. Biochem., Hokkaido Pharm. Univ.
S13-3
Reactive oxygen species (ROS), insulin hypersecretion and type 2 diabetes
Barbara E. Corkey, Deeney T Deeney, Karel A Erion, Charles Berdan, Nathan E Burritt, Orian S Shirihai
Obesity Res. Cent., Dept. of Med., Boston Univ. Sch. of Med., USA
S13-4
Impact of glutathione peroxidase (GPX) and the GPX mimic ebselen on pancreatic insulin secretion
Xin Gen Lei, Xinhui Wang
Dept. of Animal Sci., Cornell Univ., USA
Break
11:40-11:50
Meet the Professor 6
11:50-12:50
Chair: Akira Ando, Japan
Sponsored by Kyowa Kirin & ZERIA Pharmaceutical Co., Ltd.
MP-6
Cutting-edge of therapeutic strategies for patients with refractory IBD: Clinical and molecular investigation
Satoshi Tanida
Dept. of Gastroenterol. and Metab., Nagoya City Univ. Grad. Sch. of Med. Sci., Nagoya, Japan
46
SFRRI 2014
Break
12:50-13:00
Symposium 14: ROS in Peripheral Motor Neurons: The Key to ALS and Age-Related
Loss of Skeletal Muscles?
13:00-15:00
Chairs: Malcolm J. Jackson, UK
Holly Van Remmen, USA
S14-1
Understanding the role of superoxide dismutase and tyrosine nitration in Amyotrophic Lateral Sclerosis
Joseph S Beckman
Linus Pauling Inst., Oregon State Univ., USA
S14-3
Nerve-muscle redox interactions and the maintenance of muscle mass during ageing
Malcolm J Jackson, Aphrodite Vasilaki, Giorgos Sakellariou, Siobhan Scullion, Natalie Pollock, Anne McArdle
Inst. of Ageing and Chronic Dis., Univ. of Liverpool, UK
S14-4
Exercise as an intervention to preserve central and peripheral nerve function during ageing
Zsolt Radak
Fac. of PE and Sport Sci., Semmelweis Univ., Hungary
Coffee Break
15:00-15:20
Sponsored Session: Japanese Coenzyme Q Association
15:20-17:20
Mar. 25 (Tue)
S14-5
Redox regulation of muscle E3 ubiquitin ligases: role in sarcopenia
Jose Vina1, Mari Carmen Gomez Cabrera1, Beatriz Ferrando1, Arlette Delamarche2, Frederic Derbre1
1
The Univ. of Valencia, Spain, 2Univ. of Rennes, France
Sponsored by Japanese Coenzyme Q Association
SPS-1
Coenzyme Q10 in health and diseases
Plácido Navas
Cent. Andaluz de Biología del Desarrollo, Univ. Pablo de Olavide-CSIC-JA and CIBERER, Inst. de Salud Carlos III, Seville, Spain
SPS-2
Coenzyme Q10: a metabolic approach to improve heart failure outcome
S. A. Mortensen
DMSc, EFESC on behalf of the Q-SYMBIO Study Investigators
SPS-3
A potential link between the stress protein heme oxygenase-1 and coenzyme Q
R Stocker1, LL Dunn1, KH Chan2, S Kong1, C Suarna1, DL Newington1, A Ayer1, RG Midwinter3, CF Clarke4, J Cantley5,
DE James5, GJ Maghzal1, MKC Ng2
1
The Victor Chang Cardiac Res. Inst. and The Univ. of New South Wales, 2The Heart Res. Inst., Sydney, Australia,
3
The Univ. of Sydney, 4Dept. of Chem. and Biochem., Univ. of California, Los Angeles, USA, 5Garvan Inst. of Med. Res.
SPS-4
The role of prosaposin and saposin B as the coenzyme Q10 binding and transfer protein
Yorihiro Yamamoto1, Makoto Hasegawa1, Kazunari Takase1, Mayuko Nishimura1, Miyoshi Nagao1, Yoshihiro Yamazaki1,
Yuki Kakizawa1, Hiroshi Moriuchi1, Junko Matsuda2, Misato Kashiba1, Shinichi Yoshimura2
1
Sch. of Biosci. and Biotechnol., Tokyo Univ. of Tech., 2Tokai Univ.
SFRRI 2014
47
Scientific Program
Room K
Oral 9: NO
15:20-16:08
Chairs: Michael B Toledano, France
Roland Stocker, Australia
O35
A Potential role of iNOS promoter polymorphisms in pathology of P.vivax and P. falciparum infection in malaria
endemic population of Jharkhand, India
Sohail Mohammad1, Krishn P Singh2, Shadab Anwar2, Ajay Kumar Sharma1, Vahab Ali2, Binay Kumar3, Pradeep Das2,
Tridibes Adak4, Raziuddin Mohammad1
1
Univ. Dept. of Zool., Vinoba Bhave Univ., India, 2Div. of Biochem. and Mol. Biol., RMRIMS, Agamkuan, Patna, India,
3
Civil Surg., Sadar Hosp., Hazaribag, Jharkhand, India, 4NIMR, Dawarka, New-Delhi, India
O36
iNOS (inducible nitric oxide synthase) and NO donor induce S-nitrosylation and inactivation of Sirt1, a key regulator
of cell fate and metabolism
Kyungho Chang1, Masao Kaneki2, Nobuyuki Shimizu3
1
Dept. of Anesthesiol., Grad. Sch. of Med., Univ. of Tokyo, Japan, 2Dept. of Anesthesia, Massachusetts General Hosp.,
Harvard Med. Sch., 3Int’l Univ. of Health and Welfare
O37
SNO-trap: a powerful approach to the discovery of proteins regulated by reversible S-nitrosylation
Moran Benhar1, Shani Ben-Lulu1, Pnina Weisman-Shomer1, Tamar Ziv2
1
Technion-Israel Inst. of Technol., Israel, 2Smoler Protein Res. Cent. and Fac. of Biol., Technion, Haifa, Israel
O38
Biochemical characterization of mitochondrial complex III inhibition by nitric oxide
Laura B. Valdez, Dario E. Iglesias, Silvina S. Bombicino, Alberto Boveris
Inst. of Biochem. and Mol. Med. (IBIMOL, UBA-CONICET), Sch. of Pharm. and Biochem., UBA, Argentina
Oral 10: Neuroscience
16:08-16:56
Chairs: Masaichi Lee, Japan
Joao Laranjinha, Portugal
O39
Reperfusion-reoxygenation injury in fetal brains is diagnosed by magnetic resonance imaging and causes hypertonia by
a mechanism involving oxidants
Sidhartha Tan1, Alexander Drobyshevsky1, Kehuan Luo1, Ines Batinic-Haberle3, Jeannette Vasquez-Vivar2
1
Dept. Pediatrics, North Shore Univ. Health Sys. and Univ. of Chicago, USA, 2Med. Coll. of Wisconsin, Milwaukee, USA,
3
Duke Univ., Durham, USA
O40
Dopamine-mediated oxidation of methionine 127 in alpha-synuclein causes cytotoxicity and oligomerization of
alpha-synuclein
Kazuhiro Nakaso, Naoko Tajima, Yosuke Horikoshi, Tatsuya Matsura
Dept. of Med. Biochem., Tottori Univ. Fac. of Med., Japan
48
SFRRI 2014
O41
T-butyl bisphenol protects cerebral tissues from ischaemic injury
Paul Witting1, Hong Duong2, Aisling McMahon2, Genevieve Fong1, Joanne Dennis1, Saul Freedman2
1
Discipline of Pathol., The Univ. of Sydney, Australia, 2ANZAC Res. Inst., Concord, Australia
O42
Glutaredoxin 2 protects against oligodendroglial cell death during neuroinflammation
Klaudia Lepka1, K Volbracht1, N Voevodskaya2, E Bill3, H P Hartung1, Arne Holmgren4, Orhan Aktas1, C Berndt1,4
1
Neurol., Heinrich-Heine-Univ. Duesseldorf, Germany, 2Dept. of Biochem. and Biophys., Stockholm Univ., Sweden,
3
Max-Planck Inst. for Inorganic Biochem., Muelheim, Germany, 4Med. Biochem. and Biophys., Karolinska Inst., Stockholm,
Sweden
O43
Lack of APC/C-Cdh E3 ubiquitin ligase causes abnormal re-entry of neurons into cell cycle and glutamate excitotoxicity
in Alzheimer’s disease
Jose Vina, Tanja Fuchsberger, Esther Giraldo, Ana Lloret
Dept. of Physiol. Univ. of Valencia, Spain
Mar. 25 (Tue)
SFRRI 2014
49
Scientific Program
March 26 (Wednesday)
Room A
Plenary Lecture 4
8:30-9:30
Chair: Yuji Naito, Japan
Sponsored by JCBN
PL4
Redox regulation in cancer stem cells by CD44-xCT axis
Hideyuki Saya
Div. of Gene Regulation, Inst. for Advanced Med. Res. (IAMR), Sch. of Med., Keio Univ., Tokyo Japan
Break
9:30-9:40
Symposium 15: Signal Network of ROS, NO and S-Nitrosothiols
9:40-11:40
Chairs: Chang Chen, China
Alfonso Pompella, Italy
S15-1
The role of gamma-glutamyltransferase and redoxins in S-nitrosothiols metabolism and bioactivity in the vascular
system
Pierre Leroy1, Fatima Dahboul1, Caroline Perrin-Sarrado1, Caroline Gaucher1, Alfonso Pompella2
1
Univ. of Lorraine, CITHEFOR, France, 2Med. Sch., Univ. of Pisa, Italy
S15-2
Nitrite and nitrate in health, disease and therapeutics
Daniel B Kim-Shapiro
Dept. of Phys. and Translational Sci. Cent., Wake Forest Univ., USA
S15-3
Regulation of protein S-nitrosylation and protection against carcinogenesis by S-nitrosoglutathione reductase
Limin Liu
Dept. of Microbiol. and Immunol., Univ. of California, San Francisco, USA
S15-4
The critical role of Dimethylarginine Dimethylaminohydrolase-1 in regulating endogenous nitric oxide synthase
inhibitors and heart failure development
Yingjie Chen
Univ. of Minnesota, USA
Break
50
SFRRI 2014
11:40-11:50
Meet the Professor 7
11:50-12:50
Chair: Hidekazu Suzuki, Japan
Sponsored by Eisai Co., Ltd.
MP7-1
Oxidative stress and ER stress related signaling pathways in cardiovascular system
Nesrin Kartal Özer
Dept. of Biochem., Fac. of Med., Genetic and Metab. Dis. Res. Cent. (GEMHAM) Marmara Univ., Istanbul, Turkey
MP7-2
Helicobacter pylori infection and oxidative stress
Osamu Handa
Dept. of Mol. Gastroenterol. and Hepatol., Kyoto Pref Univ. of Med., Kyoto, Japan
Break
12:50-13:00
Symposium 16: Power Struggle between Repair and Cell Death
13:00-15:00
Chairs: Noriko Noguchi, Japan
Victor Darley-Usmar, USA
S16-1
Novel lipid peroxidation dependent cell death by deficiency of PHGPx
Hirotaka Imai
Sch. of Pharm. Sci. Kitasato Univ., Japan
S16-2
Mitochondrial regulation of macrophage cholesterol homeostasis
Annette Graham, Anne Marie Allen, Janice M Taylor
Dept. of Life Sci., Sch. of Health and Life Sci., Glasgow Caledonian Univ., UK
Mar. 26 (Wed)
S16-3
New aspects of 24S-hydroxycholesterol in modulating neuronal cell death
Noriko Noguchi
Fac. of Life and Med. Sci., Doshisha Univ., Japan
S16-4
Bench to beside for the powerhouse of the cell: Translational bioenergetics
Victor M Darley-Usmar
Cent. for Free Radical Biol. Univ. of Alabama at Birmingham, USA
S16-5
Metabolic struggle of G6PD-deficient cells upon oxidant challenge
Daniel Tsun-Yee Chiu1,2
1
Dept. of Med. Biotechnol. and Lab. Sci., Chang Gung Univ., Taiwan, 2Dept. of Lab. Med., Chang Gung Memorial Hosp.,
Taiwan
Coffee Break
15:00-15:20
SFRRI 2014
51
Scientific Program
Oral 11: Redox Imaging
15:20-15:56
Chair: Steven Bottle, Australia
O44
Potential of collagen-like triple helical peptides as spin probe-peptide conjugates: their application of evaluating redox
status of living animals
Hiroyuki Yasui1, Chisato M Yamazaki2, Hiroshi Nose3, Chihiro Awada4, Toshifumi Takao4, Takaki Koide2
1
Dept. of Analytical and Bioinorganic Chem., Kyoto Pharm. Univ., Japan, 2Dept. of Chem. and Biochem., Sch. of Advanced
Sci. and Eng., Waseda Univ., 3Kola-Gen Pharma InCorp., 4Lab. of Protein Profiling and Functional Proteomics, Inst. for
Protein Res., Osaka Univ.
O45
Reactive oxygen species and nitric balance determines the artery smooth muscle tension and thrombotic process:
visualization by in vivo imaging
Satoshi Nishimura
Jichi Med. Univ., Cent. for Mol. Med., the Univ. of Tokyo, Japan
O46
A unique, mitochondrially-targeted, redox-responsive probe
Steven E Bottle1, Kokleong Chong1, Kathryn E Fairfull-Smith1, Martin Lavin2
1
Fac. of Sci. and Eng., Queensland Univ. of Technol., Australia, 2QIMR, Royal Brisbane Hosp., Herston, Australia
Evening Lecture 3
16:00-16:40
Chair: Ceser Fraga, Argentina
EL3
The oncogenic properties of the redox inflammatory protein inducible nitric oxide synthase in ERa(-) breast cancer. New
insights into potential therapeutic targets
David A. Wink1, Julie Heinecke1, Lisa A. Ridnour1, Robert Cheng1, Christopher W. Switzer1,2, Sharon Glynn1,3, Stefan Ambs4
1
Radiation Biol. Branch, Natl. Cancer Inst., Natl. Inst. of Health, Bethesda, USA, 2The Rayne Inst., King Coll., London, UK,
3
Prostate Cancer Inst., NUI Galway, Ireland, 3LHC, CCR, NCI, 4Lab. of Human Carcinogenesis, Natl. Inst. of Health,
Bethesda, USA
Evening Lecture 4
16:40-17:20
Chair: Yang Liu, China
Sponsored by SFRR Asia
EL4
Mechanism-based drug design: A bis-resorcinol congener of resveratrol as a potential of anti-ulcer drug
Sudhir K. Yadav, Subrata Chattopadhyay
Bio-Organic Div., Bhabha Atomic Res. Cent., Mumbai, India
Break
17:20-17:30
Closing Remarks & Award Ceremony
17:30-18:00
Chairs of SFRRI2014: Yuji Naito, Japan
Shinya Toyokuni, Japan
52
SFRRI 2014
Room B1
Symposium 17: Oxidative Stress and Autophagy
9:40-11:40
Chairs: Jianhua Zhang, USA
Keiji Tanaka, Japan
S17-1
Oxidative stress, mitophagy, and the PINK1-Parkin system
Keiji Tanaka
Tokyo Metropolitan Inst. of Med. Sci., Japan
S17-2
Regulation of innate immune response by autophagy
Tatsuya Saitoh
Lab. of Host Defense, Immunol. Frontier Res. Cent., Osaka Univ., Japan
S17-3
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
Masaaki Komatsu
Protein Metab. Project, Tokyo Met. Inst. Med. Sci., Japan
S17-4
Metabolic regulation of autophagy and bioenergetics
Jianhua Zhang
Dept. of Path., Univ. Alabama, Birmingham, USA
Break
11:40-11:50
Meet the Professor 8
11:50-12:50
Mar. 26 (Wed)
Chair: Yuji Naito, Japan
Sponsored by JIMRO Co., Ltd.
MP8-1
Apoptotic cell injection ameliorates intestinal inflammation—possible mechanism of granulocyte/monocyte apheresis
Shunji Ishihara
Dept. of Internal Med. II, Shimane Univ. Sch. of Med., Izumo, Japan
MP8-2
Peroxiredoxin-6 in inflammatory bowel disease
Tomohisa Takagi
Mol. Gastroenterol. and Hepatol., Grad. Sch. of Med. Sci., Kyoto Pref. Univ. of Med., Kyoto, Japan
Break
12:50-13:00
SFRRI 2014
53
Scientific Program
Symposium 18: Reactive Oxygen Species in Non-Apoptotic Cell Death Signaling and
Necropathies
13:00-15:00
Chairs: Marcus Conrad, Germany
Peter Vandenabeele, Belgium
S18-1
Molecular mechanism of necroptosis: MLKL compromises plasma membrane integrity
Yves Dondelinger,1,2 Wim Declercq,1,2 Sylvie Montessuit,3 Ria Roelandt,1,2 Amanda Goncalves,4 Inge Bruggeman,1,2
Paco Hulpiau,1,2 Kathrin Weber,1,2 Savvas Savvides,5 Jean-Claude Martinou,3 Mathieu JM Bertrand,1,2 Peter Vandenabeele1,2,6
1
VIB Inflam. Res. Cent., Belgium, 2Dept. of Biomed. Mol. Biol., Ghent Univ., 3Dept. of Cell Biol., Univ. of Geneva,
4
Microscopy Core Facility, Dept. for Mol. Biomed. Res., VIB/Ghent Univ., 5Unit for Struct. Biol. and Biophys., Lab. for
Protein Biochem. and Biomol. Eng., Ghent Univ., 6Methusalem Program, Ghent Univ.
S18-2
Reacting to ROS and DAMPs - making amends: The ‘Damage Associated Molecular Pattern (DAMP) hypothesis’ in
cancer biology
Michael T. Lotze
Univ. of Pittsburgh, USA
S18-3
Alternative HMGB1 redox states in the tissue response to cell death
Marco Bianchi, Emilie Venereau
Div. of Genetics and Cell Biol., San Raffaele Sci. Inst. and Univ., Italy
S18-4
ROS-mediated modulation of necroptosis by Smac mimetic
Simone Fulda
Inst. for Experimental Cancer Res. in Pediatr., Goethe-Univ. Frankfurt, Germany
S18-5
Probing cell death with small molecules
Brent R. Stockwell
Howard Hughes Med. Inst., Columbia Univ., New York, USA
Coffee Break
15:00-15:20
Oral 12: Aging
15:20-16:08
Chairs: Juan Sastre, Spain
Peter Rabinovitch, USA
O47
Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease
Lin-Hao You, Fei Li, Lan Wang, Peng Yu, Shu-E Zhao, Yan-Zhong Chang
Dept. of Life Sci., Hebei Normal Univ., China
O48
Mitochondrial theory of reproduction and ovarian aging
Masayasu Inoue1, Eisuke F Sato3, Shu Hashimoto2, Yoshiharu Morimoto2
1
Health Sci. Lab., Japan, 2IVF Japan, 3Suzuka Univ. of Med. Sci.
54
SFRRI 2014
O49
Propanoylation of amyloid  is the key post-translational modification to enhance its aggregability and neurotoxicity in
Alzheimer disease
Shinsuke Hisaka1, Hiroyasu Akatsu2, Masayo Shamoto-Nagai3, Yoji Kato4, Mitsuhiko Nose1, Wakako Maruyama3,
Toshihiko Osawa5
1
Fac. of Pharm., Meijo Univ., Japan, 2Fukushimura Hosp., 3Natl. Cent. of Geriatrics and Gerontol., 4Sch. of Human Sci. and
Environ., Univ. of Hyogo, 5Fac. of Psychol. and Phys. Sci., Aichi Gakuin Univ.
O50
C. elegans as a model for investigations into basic mechanisms of ageing what can and cannot be learned?
Jan Gruber1,2, Li Fang Ng1, Rudiyanto Gunawan3, Barry Halliwell1
1
Dept. of Biochem. Natl. Univ. of Singapore, Yale-NUS Coll., Singapore, 2Yale-NUS Coll., Singapore, 3Inst. for Chem. and
Bioeng., ETH Zurich, Switzerland
Oral 13: Cancer 2
16:08-16:56
Chairs: Futoshi Okada, Japan
Marco Bianchi, Italy
O51
CBX7 expression is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic
pathway regulation
Yoriko Yamashita1, Kanako Shinjo2, Shinya Akatsuka2, Shinya Toyokuni2
1
Dept. of Experimental Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci., Japan, 2Dept. of Pathol. and
Biol. Responses, Nagoya Univ. Grad. Sch. of Med.
O52
The role of HSP70 in the chemotherapeutic approach for proteasomal degradation and autophagy
Erdi Sozen1, Perinur Bozaykut1, Nesrin Kartal Ozer1, Tilman Grune2, Betul Karademir1
1
Dept. of Biochem., Med. Fac. / Gen. Met. Dis. Res. Invest. Cent., Marmara Uni., Istanbul, Turkey, 2Dept. of Nutr. Toxic.,
Inst. of Nutr., Friedrich Schiller Univ., Jena, Germany
Mar. 26 (Wed)
O53
Overexpression of multidrug transporters ABCB1 and ABCG2 confers increased sensitivity to oxidative stress
Damian Krzyzanowski, Grzegorz Bartosz, Agnieszka M. Grzelak
Dept. of Mol. Biophys., Univ. of Lodz, Poland
O54
Mitochondrial transfer from stromal cells to tumour cells depleted of their mitochondrial DNA restores respiration and
tumour-initiating capacity
Jiri Neuzil1, An Tan3, James Baty3, Berwini Endaya1, Ayanachew Bezawork-Geleta1, Martina Bajzikova2, Bing Yan1,
Jacob Goodwin1, Elham Alizadeh1, Martin Peterka2, Lan-Feng Dong1, Mike Berridge3
1
Malaghan Inst., Victoria Univ., Wellington, New Zealand, 2Inst. of Biotechnol., Academy of Sci., Prague, Czech Republic,
3
Malaghan Inst., Victoria Univ., Wellington, New Zealand
SFRRI 2014
55
Scientific Program
Room B2
Symposium 19: New Insights and Current Concepts of Aging
9:40-11:40
Chairs: Yuji Ikeno, USA
Warren Ladiges, USA
Sponsored by Japanese Society of Anti-Aging Medicine
S19-1
Role of oxidative stress and redox regulation on cognitive function
Ting-Ting Huang1,2, David Leu1, Yani Zou1, Rikki Corniola1, John R Fike3
1
Dept. of Neurol. and Neurological Sci., Stanford Univ. Sch. of Med., USA, 2Geriatric Res., Edu., and Care Cent., VA Palo
Alto Health Care Sys., 3Dept. of Neurosurgery and Radiation Oncol.
S19-2
Mitochondrial ROS and energetics play a central role in interventions that enhance cardiac health and aging
Peter S Rabinovitch1, Dao-Fu Dai1, Ying A Chiao1, Pabalu P Karunadharma1, Nathan B Basisty1, Edward J Hsieh2,
Hazel H Szeto3, Michael J MacCoss2
1
Dept. of Pathol., Univ. of Washington, USA, 2Dept. of Genome Sci., Univ. of Washington, Seattle, USA, 3Dept. of
Pharmacol., Weill Cornell Med. Coll., New York, USA
S19-3
Exercise delays age-related cancer driven by tissue hypoxia and mitochondrial ROS
Warren Ladiges
Dept. of Comparative Med., Sch. of Med., Univ. of Washington, USA
S19-4
Mechanisms that extend lifespan in Sprague-Dawley rats overexpressing Cu/ZnSOD
Yuji Ikeno
Barshop Inst., UTHSCSA, USA
Break
11:40-11:50
Meet the Professor 9
11:50-12:50
Chair: Giovanni E. Mann, UK
Sponsored by Daiichi Sankyo Co., Ltd.
MP9
Cyclophilin A: A novel biomarker for oxidative stress and cardiovascular diseases
Kimio Satoh, Hiroaki Shimokawa
Dept. of Cardiovascular Med., Tohoku Univ. Grad. Sch. of Med., Sendai, Japan
Break
56
SFRRI 2014
12:50-13:00
Symposium 20: New Aspect of Antioxidative Therapy
13:00-15:00
Chairs: Yukio Nagasaki, Japan
Aki Hirayama, Japan
S20-1
Novel redox polymer therapeutics for antioxidative injuries
Yukio Nagasaki1,2,3
1
Dept. of Mater. Sci., Univ. of Tsukuba, Japan, 2Dept. of Med. Sci., Univ. of Tsukuba, 3Satellite Lab. at Univ. of Tsukuba,
WPI-MANA, NIMS
S20-2
Cell-mediated delivery of redox enzymes for treatment of neurodegenerative disorders
Elena V. Batrakova1, Matthew J. Haney1, Yuling Zhao1, Emily B. Harrison2, Vivek Mahajan1,3, Shaheen Ahmed2,
Zhijian He1, Shawn D. Hingtgen4, Natalia L. Klyachko1,5, R. Lee Mosley3, Howard E. Gendelman3,
Alexander V. Kabanov1,5
1
Eshelman Sch. of Pharm., Univ. of North Carolina, USA, 2Dept. of Pharm. Sci., Cent. for Drug Delivery and Nanomed.,
Univ. of Nebraska Med. Cent., 3Dept. of Pharmacol. and Experimental Neurosci., Cent. for Neurodegenerative Disorders,
Univ. of Nebraska Med. Cent., 4Eshelman Sch. of Pharm., Univ. of North Carolina, 5Dept. of Chem. Enzymol., Fac. of
Chem., M.V. Lomonosov Moscow State Univ., Moscow, Russia
S20-3
Metabolites of lycopene and prostate cancer risk
John W Erdman, Jr.1, Josh W Smith1, Nancy E Moran2, Steven K Clinton2
1
Dept. of Food Sci. and Human Nutr., Univ. of Illinois, USA, 2Dept. of Internal Med., The Ohio State Univ.
S20-4
Oxidative metabolism of dietary xanthophylls and their implications for bioavailability and function
Akihiko Nagao
Natl. Food Res. Inst., NARO, Japan
15:00-15:20
Oral 14: Macromolecle Modification
15:20-16:08
Mar. 26 (Wed)
Coffee Break
Chairs: Susumu Takekoshi, Japan
Daniel Kim-Shapiro, USA
O55
The inflammation-associated oxidant peroxynitrous acid modifies the extracellular matrix generated by human coronary
artery endothelial cells
Christine Y Chuang1,2, Georg Degendorfer1,2, Astrid Hammer3, John M Whitelock4, Ernst Malle5, Michael J Davies1,2
1
The Heart Res. Inst., Australia, 2Fac. of Med., Univ. of Sydney, Australia, 3Inst. of Cell Biol., Histol. and Embryol., Med.
Univ. of Graz, Austria, 4Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Australia, 5Inst. of Mol. Biol. and Biochem.,
Med. Univ. of Graz, Austria
O56
Myeloperoxidase-derived oxidants disrupt the iron-sulfur cluster of aconitase of human coronary artery endothelial cells
Jihan Talib, Naomi L Cook, Michael J Davies
The Heart Res. Inst., Australia
SFRRI 2014
57
Scientific Program
O57
Peroxynitrous acid induces structural and functional modification of extracellular matrix and its key component,
laminin
Georg Degendorfer1,2, Christine Y. Chuang1, Ernst Malle3, Michael J. Davies1,2
1
The Heart Res. Inst., Newtown, Australia, 2Fac. of Med., The Univ. of Sydney, Australia, 3The Inst. of Mol. Biol. and
Biochem., Med. Univ. of Graz, Austria
Oral 15: Inflammation, Infection, Immunity
16:08-16:56
Chairs: Simone Fulda, Germany
Junji Terao, Japan
O58
Role of chlorinated nucleosides produced by hypochlorous acid in the perturbation of cellular function under
inflammatory conditions
Jessica Macer-Wright1,2, Naomi Stanley1,2, Joanne Tan1,2, Christina Bursill1,2, Clare L. Hawkins1,2
1
Heart Res. Inst., Newtown, Australia, 2Fac. of Med., Univ. of Sydney, Australia
O59
Carbon monoxide releasing molecule-3 (CORM3) suppresses human cerebrovascular endothelial cell pro-adhesive
phenotype by inhibiting JNK/AP-1 signaling
Fukashi Serizawa1,2, Eric K. Patterson2, Richard F Potter2,3, Douglas D Fraser2, Gediminas Cepinskas2,3
1
Dept. of Transplant., Reconstruct. and Endoscopic Surg., Tohoku Univ. Hosp., Japan, 2Cent. for Critical Illness Res.,
Lawson Health Res. Inst., London, Ontario, Canada, 3Dept. of Med. Biophys., Western Univ., London, Ontario, Canada
O60
The ischemia-reperfusion injury in the skeletal muscle is diminished by the systemic application of CO-Releasing
Molecule (CORM-3)
Aurelia Bihari1,3,4, Gediminas Cepinskas1, Thomas L Forbes2,4, Richard F Potter1, Abdel-Rahman Lawendy1,3,4
1
Cent. for Critical Illness Res., Lawson Health Res. Inst., Canada, 2Vascular Surg., London Health Sci. Cent., London,
Canada, 3Orthopaedic Surg., London Health Sci. Cent., London, Canada,4Surg., Univ. of Western Ontario, London, Canada
O61
Glutathione peroxidase 2 interferes with NF-B signaling
Anna P. Kipp, Manuel Modraeger, Mike F. Mueller, Regina Brigelius-Flohe
Dept. Biochem. of Micronutrients, German Inst. of Human Nutr. Potsdam-Rehbruecke, Germany
58
SFRRI 2014
Room K
Author Workshop: How to write a great research paper, and get it accepted by a good journal
13:00-15:00
Chair: Shinya Toyokuni, Japan
Sponsored by Elsevier
AW
How to write a great research paper, and get it accepted by a good journal
Anthony Newman
Life Sci. Dept., Elsevier, Amsterdam, The Netherlands
Coffee Break
15:00-15:20
Oral 16: Cardiovascular 2
15:20-16:08
Chairs: Christian Schoneich, USA
Philip Eaton, UK
O62
Characterization of redox modifications in cardiac DJ-1 during oxidative stress and its interaction with peroxiredoxin
Mariana Fernandez-Caggiano, Ewald Schroder, Joseph Burgoyne, Philip Eaton
Cardiovascular Div. King’s Coll. London, UK
O63
Regulation of arterial remodeling through interaction of Sequestosome1/p62 with redox-sensitive Kv channels
Tetsuro Ishii1,2, Eiji Warabi1, Richard C. Siow2, Giovanni E Mann2
1
Univ. of Tsukuba, Japa