Welcome Sanesco Clinical Advisory Board

A Neuroendocrine Model for
Healthy Aging
Speaker: Sharon Norling, MD, MBA
December 13, 2013
Booth - 3046
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Surgery
Medicine
Prevalence of Mood Disorders
S 26.2% 18 and older – about 1 in 4 adults.
S 57.7 million people
S 45% meet criteria for 2 or more disorders
S Comorbidity
1. Kessler RC, Archives of General Psychiatry, 62(6) (January 2005): 617-27.
2. U.S. Census Bureau Population Estimates by Demographic Characteristics.
CLIA High Complexity Clinical
Testing Laboratory
CLIA: 34D1054007
NeuroLab™
S Laboratory results include integrative clinical commentary
personalized to the patient health data and current laboratory
values.
S Personalized medicine
S Treating the average is
S Neuroendocrine systems analysis of chronic and acute
conditions from depression to metabolic syndrome
Inhibitory Neurotransmitters
S Serotonin
S GABA
Excitatory Neurotransmitters
S Dopamine
S Nor-epinephrine
S Epinephrine
S Glutamate
Adrenal Hormones
S DHEA-s – (2-point)
S Cortisol – (4-point)
Neurotransmitters
Anxious?
Depressed?
Mood swings?
Difficulty sleeping?
Experiencing pain?
Lacking motivation?
Low libido?
Pharmaceutical Drugs
S Mood-altering drugs are considered affective if it
reduces depression 50%
S SSRI’s help 30-50 % of the time but have side effects
86% of the time
S Turner looked at 74 clinical trials and found the drug
worked 51% and the placebo 49%
Erick H Turner MD, et al. “Selective Publication of Antidepressant Trials and Its
Influence on Apparent Efficacy,” NEJM (January 17, 2008); 358: 252-60.
Evolution of Model Mood
Disorders
S Middle Ages: Demons within-exorcism is therapy of choice
S 1917: Freud explains that those demons are really our
mothers
S 1988: Eli Lilly releases our mothers from 80 years of
victimization, explaining that depression is really a Prozac
deficiency
Dr. Hedaya, Clinical Professor of Psychiatry Georgetown University.
Disease Management & the
Organization of Physician
Practice
“There is a large gap between what
physicians do for patients with
chronic diseases and what should be
done.”
Disease Management and the Organization of Physician Practice
Lawrence P. Casalino, MD, PhD
JAMA. 2005;293(4):485-488.
Causes of Neurotransmitter
Imbalance
S Life
S Low thyroid
S Gluten
S Adrenal fatigue
S Lack of nutrition and
S Toxins
blood sugar
S Hormone imbalance
S Infections
S Lack of sleep
LIFE
Causes of Neurotransmitter
Imbalance
S Life
S Low thyroid
S Gluten
S Adrenal fatigue
S Lack of nutrition and
S Toxins
blood sugar
S Hormone imbalance
S Infections
S Lack of sleep
Gluten Sensitivity
S Depression in 52%
S Injured GI lining decreases the effectiveness of absorbing
essential nutrients to keep the brain healthy.
S Zinc, tryptophan, and B Vitamins
S “second brain” produces 80-90 percent of serotonin
Causes of Neurotransmitter
Imbalance
S Life
S Low thyroid
S Gluten
S Adrenal fatigue
S Lack of nutrition and
S Toxins
blood sugar
S Hormone imbalance
S Infections
S Lack of sleep
Vitamin D
S Low levels contribute to depression and chronic fatigue
S Adequate Vitamin D needed by the adrenal gland for the
production of dopamine, epinephrine, and norepinephrine
S Several months of supplementation
High Blood Sugar
“when your blood sugar rises there is an
immediate depletion of the neurotransmitters
serotonin, epinephrine, norepinephrine, GABA,
and dopamine. B-complex, which is needed to
make neurotransmitters, gets used up.”
David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and
Company, 2013).
High Blood Sugar
“ The most powerful tool you have to change
your body and your health is your fork.”
Mark Hyman, MD
Causes of Neurotransmitter
Imbalance
S Life
S Low thyroid
S Gluten
S Adrenal fatigue
S Lack of nutrition and
S Toxins
blood sugar
S Hormone
imbalance
S Infections
S Lack of sleep
Hormone Imbalance: Statins
“If you deprive the brain of cholesterol, then you
directly affect the machinery that triggers the release
of neurotransmitters.
Cholesterol changes the shape of the proteins to
stimulate thinking and memory.”
David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and
Company, 2013).
Hormones & Neurotransmitters
S Strong interaction E2 and serotonin
S Progesterone and GABA
S Testosterone and DHEA
Causes of Neurotransmitter
Imbalance
S Life
S Gluten
S Lack of nutrition and
blood sugar
S Hormone imbalance
S Low thyroid
S Adrenal fatigue
S Toxins
S Infections
S Lack of sleep
Symptoms of Low Thyroid
Production
S Depression
S Anxiety
S Decreased memory
S Inability to concentrate
S Migraine headaches
S Muscle and joint pain
S Menopausal symptoms and PMS
S Insomnia
S Fatigue
S Low libido
Causes of Neurotransmitter
Imbalance
S Life
S Low thyroid
S Gluten
S Adrenal fatigue
S Lack of nutrition and
blood sugar
S Hormone imbalance
S Toxins
S Infections
S Lack of sleep
Adrenal Hormones
S DHEA-s
S Cortisol
Dancing Hormones
Adrenaline
GABA
Cortisol
Thyroid
Insulin
Serotonin
Estrogen
Progesterone
Dopamine
Glutamate
DHEA
Testosterone
NeuroLab™
S Leading specialist in the technology, analysis, and
research of the biomarkers relating to HPA-T axis
function.
S Leaders in the clinical application of urinary HPLC/MS
testing.
S Certified by CLIA as High Complexity Clinical
Laboratory
S Participates in College of American Pathology &
BIORAD proficiency testing for salivary samples.
Amino acids
“We have found that if a drug can be found to do the job of
medical healing, a nutrient can be found to do the same job.
We now know that if we give the amino acids the body will
synthesize neurotransmitters, thereby achieving the same effect
as drugs.
The challenge of the future is to replace drugs with these
natural healers.”
Dr. Carl Pfeiffer, a pioneer amino-acid researcher.
Step 1: Assessment
•
Assess the
patients’ neurotransmitter and
adrenal hormone biomarkers
with a non-invasive laboratory
test
•
Establishes a baseline on first
test, looking for imbalances
affecting HPA-T axis function.
•
Important tool for monitoring
and adjusting therapy to meet
the patient’s individual
biochemical needs
Step 2: Correlation
•
Personalized laboratory results
to patient specific symptoms
and, current treatments, and
lifestyle factors
•
Comprehensive review
of patient’s neuroendocrine
system
Step 3: Correction
S Sanesco’s exclusive line of TNT
products are natural, non-drug
formulas balanced with specific
low dose amino acid precursors
and nutrient cofactors designed
to support neurotransmitter and
hormone pathways showing
imbalances affecting HPA-T axis
function.
Targeted Nutritional Therapysafe & clinically effective
S Prolent™ (inhibitory support)
S Contegra™ (catecholamine formula)
S Lentra™ (GABA receptor
S MethyMax™ (methylation support)
support)
S Procite-D™ (dopamine support)
S Adaptacin™ (adrenal support)
Effective Clinical Tool
1.
Symptomatic patient does a test
2.
Test reveals a number
3.
Intervention is made
4.
Test is repeated
5.
Number improves
Hormones
Neurotransmitters
Gluten
Sensitivity
Neurotransmitters
•Anxiety
•Anxiety
•Anxiety
•Depression
•Depression
•Depression
•Insomnia
•Insomnia
•Insomnia
•Fatigue
•Fatigue
•Fatigue
•Anxiety
•Memory Loss
•Joint Pain
•Joint Pain
•Depression
•Poor Concentration •Joint Pain
•Insomnia
•Low Libido
•Memory Loss
•Memory
Loss
•Memory Loss
•Fatigue
•Carb Cravings
•Poor Concentration•Joint•Poor
•Poor Concentration
Pain Concentration
•Muscle stiffness
•Low Libido
•Low Libido
•Low Libido
•Carb Cravings
•Carb Cravings
•Carb Cravings
Gluten
Sensitivity
Hormones
•Muscle stiffness
•Muscle stiffness
•Muscle stiffness
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Summary
S Assess patients for mood disorders
S Remove known causes of imbalances
S Test using NeuroLab, leading specialty laboratory in
the technology, analysis, and research of HPA-T axis
function
S Balance neurotransmitters with Sanesco’s specific
amino acid targeted nutrient therapy for safe effective
clinical results
Neurotransmitters
Anxious?
Depressed?
Mood swings?
Difficulty sleeping?
Experiencing pain?
Lacking motivation?
Low libido?
Question
Is there
SEX
before or after menopause ?
Sexual Frequency Across the
Life Cycle
Age
Frequency
S 30-40
Tri - weekly
S 40-50
Try weekly
S 50-60
Try weakly
S 60-70
Try
S 70-80
Try something else
Remember
Laughter is the BEST Medicine
A Neuroendocrine Model for
Healthy Aging
Dr. Sharon Norling
5655 Lindero Canyon Rd
Westlake Village, CA
Your Doctor is Wrong
www.drsharonnorling.com
Come by booth 3046 for an opportunity to
meet Sharon Norling MD, MBA and
receive a signed copy of the her book.
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Continue the Conversation with
Us
Booth - 3046
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