* , , * X 30 102 TempbondTM (mucogingival junction, MGJ) X X
Transcription
* , , * X 30 102 TempbondTM (mucogingival junction, MGJ) X X
* , , * X 30 102 TempbondTM (mucogingival junction, MGJ) X X (presence) (Image J software) [1] [2] (contact point) (length of the papilla) [3] (interdental distance) (p<0.001) (bone crest) (keratinized gingiva) [4] [1] [2] (p<0.05) [3] 5mm X ( 13:269-278, 2008) X (interproximal dental papilla) 1 2 (Black triangle, dark triangle, or black (gingival col) hole problem) : 97 area) 6 15 , : : 97 8 20 , (contact 3-5 : 97 10 16 222 5 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 269 [2] (cementoenamel junction, CEJ) 6 [3] [4] Olsson and Lindhe7 (thin and scalloped) (thick 2007 9 2007 12 30 8-10 and flat) 20 7 Kurth and Kokich11 5mm (interdental black triangle) [Plaque and Gingival index 38% (Loe & Silness 1963)17] 0 1 (embrasure) (spacing) MacGuire12 Kassab and Cohen13 88% 18 64 (crowding) 2:1 65 Tempbond˛ (Kerr dental, West Collins Orange, CA) 50% 90 Chang 14 (mucogingival (interdental distance) junction, MGJ)( 14 ) X Tarnow et al.2 Dentsply RinnXCP film holder X X 5mm 7mm Wu et al.15 X Chang 16 X [1] 270 Tempbond™ J Taiwan Periodontol 13. No4. 2008 (Nikon Coolpix 4500, Nikon, New York, USA) 2272*1704 30 JPEG 18-20 5 Image J (NIH free software) ( [Generalized Estimating Equations (GEE) 21,22 ] ) D3 D1 D4 D1 D2 GEE D2 D3 ( ) D4 30 78 [ (mean) 28 53.8 150 X 11.5 years] 48 (spacing) (crowding) 102 (D1) 5.23 (D2) 3.82 0.71 mm (D3) 4.41 (D4) 1.65 1.63 mm 1.29 mm 0.66 mm( ) GEE (D1) 3 5mm 4mm 100% 77.78% D1 91.49% mm 6mm D1 5 D1 7.69% GEE (P<0.001) D1: ( ) D2: (D2) D3: ( ) mm 4 5mm 3 6 GEE D4: (P=0.5781)( J Taiwan Periodontol 13. No4. 2008 ) 271 D1, D2, D3, D4 (mean value) (mm) D1 D2 D3 D4 5.23 ± 1.63 3.82 ± 0.71 4.41 ± 1.29 1.65 ± 0.66 (Parameter) (Estimate) (SE of Estimate) D1 -4.775 0.7575 < 0.001 D2 -0.1677 0.3014 0.5781 D3 0.0488 0.1504 0.7485 D4 -0.8667 0.2886 < 0.05 GEE P (D1) 3 4 5 6 7 8 9 10 9 20 14 43 2 0 0 0 0 45 0 0 4 4 24 15 8 4 2 57 9 20 18 47 26 15 8 4 2 102 (%) 100 100 77.78 91.49 7.69 0 0 0 0 44.12 (%) 0 0 22.22 8.51 92.31 100 100 100 100 55.88 (D2) 272 3 4 5 6 9 20 14 2 45 6 31 18 2 57 15 51 32 4 102 (%) 60 39.21 43.75 50 44.12 (%) 40 60.79 56.25 50 55.88 J Taiwan Periodontol 13. No4. 2008 (D3) 2 3 4 5 6 7 8 0 6 12 11 11 4 1 45 2 8 14 10 18 5 0 57 2 14 26 21 29 9 1 102 (%) 0 42.86 46.15 52.38 37.93 44.44 100 44.12 (%) 100 57.14 53.85 47.62 62.07 55.56 0 55.88 (D4) 1 2 3 4 10 28 7 0 45 8 32 14 3 57 18 60 21 3 102 (%) 55.56 46.67 33.33 0 44.12 (%) 44.44 53.33 66.67 100 55.88 (D3) 4 6mm 2mm 2 8mm 8mm (P<0,001) D4 (P=0.2612) GEE D1 5mm (P=0.7485)( ) (D4) D1 3mm 77.78% 6mm 7.69% D1=5mm (odds ratio) (odds) 5.527 GEE (P<0.05)( D1 5mm ) D1 D4 GEE D1 J Taiwan Periodontol 13. No4. 2008 273 1 Chang14,16,38,39 (diastema)5 Caviton (GC Coporation, Tokyo, Japan) 23 X Caviotn (interdental black triangle) MGJ 23 X 24-28 Tempbond TM 29 Tempbond TM 30-34 Tempbond TM 35 X Tempbond TM (interdental black triangle) Tarnow2 X 5 mm 100% Tarnow2 5mm X 15,16 al.18 5mm 77.78%(14/18) Tarnow et al.2 Lee et 98% X Wu et al.15 X Tarnow et al.2 Tarnow X Tarnow et al. 2 Wu et al.15 Lee et al. 18,36,37 endodontic sealer (Tubil- Seal, Kerr dental, West Collins Orange, CA.) MGJ (1mm ) X endodontic sealer 274 J Taiwan Periodontol 13. No4. 2008 Chang16 X TempbondTM Lee et al.37 Gastaldo 40 5mm 3mm 3mm 1. Kokich VG. Adjunctive role of orthodontic therapy. In : Newman MG, Takei HH, Klokkevold PR & Carranza, FA (eds). Carranza's Clinical Periodontology, 10th edition, pp. Missouri: Elseiver Inc; 856-870, 2006. Chang 39 2. Tarnow DP, Magner AW, Fletcher P. The effect of the distance from the contact point to the crest of bone on the presence or (multif- actorial logistic regression) absence of the interproximal dental papilla. J Periodontol, 63: 995-996, 1992. 3. Cohen B. Morphological factors in the (confounding factors) pathogenesis of periodontal disease. Brit Dent J, 107: 31-39, 1959. 4. Cohen B. A study of the periodontal epithelium. Brit Dent J, 112: 55-64, 1962. 5. Fiorellini JP, Kim DM, Ishikawa SO. The gingiva. In: Newman MG., Takei HH, Klokkevold PR & Carraza FA (eds). GEE Carranza 5mm s Clinical Periodontology, 10th edition, pp. Missouri: Elseiver Inc, 46-67, 2006. J Taiwan Periodontol 13. No4. 2008 275 6. Lindhe J, Karring T. Anatomy of the periodontium. In : Lindhe J, Karring T, Lang NP, eds. Clinical Periodontology and Implant Dentistry, 3rd ed. Copenhagen: Munksgaard, 19-68, 1998. 7. Olsson M, Lindhe J. Periodontal characteristics in individuals with varying form of the upper central incisors. J Clin Periodontol, 18: 7882, 1991. 8. Oschsenbein C, Ross S. A reevaluation of osseous surgery. Dental Clinics of North America, 13: 87-102, 1969. 9. Becker W, Oschsenbein C, Tibbetts L, Becker BE. Alveolar bone anatomic profiles as measured from dry skulls: clinical ramifications. J Clin Periodontol, 24: 727-731, 1997. 10. Weisgold A. Contours of the full crown restoration. Alpha Omegan, 70: 70-77, 1997. 11. Kurth JR, Kokich VG. Open gingival embrasure after orthodontic treatment in adults: prevalence and etiology. Am J Orthod Dentofacial Orthop, 120: 116-123, 2001. 12. McGuire MK, Miller L. Maintaining esthetic restorations in the periodontal practice. Int J Periodontics Restorative Dent, 16: 231-239, 1996. 13. Kassab MM, Cohen RE. The etiology and prevalence of gingival recession. J Am Dent Assoc, 134: 220-225, 2003. 14. Chang LC. The presence of a central papilla is associated with age but not gender. J Dent Sci, 1(4): 161-167, 2006. 15. Wu YJ, Tu YK, Huang SM, Chan CP. The influence of the distance from the contact point to the crest of bone on the presence of 276 16. 17. 18. 19. 20. 21. 22. 23. 24. the interproximal dental papilla. Chang Gung Med J, 26: 822-828, 2003. Chang LC. The association between embrasure morphology and central papilla recession. J Clin Periodontol, 34: 432-436, 2007. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica, 21: 533-551, 1963. Lee DW, Kim CK, Park KH, Cho KS, Moon IS. Non-invasive method to measure the length of soft tissue from the top of the papilla to the crestal bone. J Periodontol, 76: 1311-1314, 2005. Attaelmanan A, Borg E, Gronndahl HG. Digitisation and display of intra-oral films. Dentomaxillofac Radiol, 29: 97-102, 2000. Kim TS, Ben DK, Eickholz P. Accuracy of computer-assisted radiographic measurement of interproximal bone loss in vertical bone defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94: 379-387, 2002. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika, 73: 13-22, 1986. Liang KY, Zeger SL. Regression analysis for correlated data. Annu Rev Public Health, 14: 43-68, 1993. Agudio G, Pini Prato GP, Nevins M, Cortenilli P, Ono Y. Esthetic modifications in periodontal therapy. Int J Periodontics Restorative Dent, 9: 288-299, 1989. Ingber JS. Forced eruption: Part 1. A method of treating one and two wall infrabony osseous defects-Rationale and case report. J J Taiwan Periodontol 13. No4. 2008 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. Periodontol, 45: 199-206, 1974. Ingber JS. Forced eruption: Part 2. A method of treating nonrestorable teeth- Periodontal and restorative considerations. J Periodontol, 47: 203-216, 1976. Ingber JS, Rose LF, Coslet JG. The "biological width" - A concept in periodontics and restorative dentistry. Alpha Omegan, 10: 62-65, 1977. Ingber JS. Forced eruption: alteration of soft tissue cosmetic deformities. Int J Periodontics Restorative Dent, 9: 417-425, 1989. Ingber JS. Forced eruption. In: Marks MH. Corn H (eds). Atlas of Adult Orthodontics: Functional and Esthetics Enhancement. Philadelphia: Lea & Febiger, 413-447, 1989. Miller PD, Allen EP. The development of periodontal plastic surgery. Periodontol 2000, 11: 7-17, 1996. Shapiro A. Regeneration of interdental papillae using periodic curettage. Int J Periodontics Restorative Dent, 5(5): 27-33, 1985. Beagle JR. Surgical reconstruction of the interdental papilla: Case report. Int J Periodontics Restorative Dent, 12: 144-151, 1992. Han TJ, Takei HH. Progress in gingival papilla reconstruction. Periodontol 2000, 11: 65-68, 1996. Azzi R, Etienne D, Zarranza F. Surgical reconstruction of the interdental papilla. Int J Periodontics Restorative Dent, 18: 467-473, 1998. Tinti C, Parma Benfenati S. The ramp J Taiwan Periodontol 13. No4. 2008 35. 36. 37. 38. 39. 40. mattress suture: A new suturing technique combined with a surgical procedure to obtain papillae between implants in the buccal area. Int J Periodontics Restorative Dent, 22: 6369, 2002. Miller PD Jr. Root coverage using a free soft tissue autograft following citric acid application. Part I: Technique. Int J Periodontics Restorative Dent, 2(1): 65-70, 1982. Lee DW, Park KH, Moon IS. Dimension of interproximal soft tissue between adjacent implants in two distinctive implant systems. J Periodontol, 77: 1080-1084, 2006. Lee DW, Park KH, Moon IS. Dimension of keratinized mucosa and the interproximal papilla between adjacent implants. J Periodontol, 76: 1856-1860, 2005. Chang LC. The central papilla height in association with age and gender-assessed with a new method. Chin J Periodontol, 11: 271-279, 2006. Chang LC. Assessment of parameters affecting the presence of the central papilla using a non-invasive radiographic method. J Periodontol, 79:603-609, 2008. Gastaldo JF, Cury PR, Sendyk WR. Effect of the vertical and horizontal distances between adjacent implants and between a tooth and an implant on the incidence of interproximal papilla. J Periodontol, 75: 1242-1246, 2004. 277 Factors influencing the presence or recession of the interproximal dental papilla Min-Chieh Chen, Chiu-Po Chan, Whei-Lin Pan, Yuh-Ren Ju, Yu Fang Liao* Department of Periodontics, *Craniofacial Orthodontics, Chang Gung Memorial Hospital, Keelung and Taipei Chang Gung University The presence of interproximal dental papillae between maxillary anterior teeth is a key esthetic factor of great concern to dentists and patients. The purpose of this study was to determine the factors that might influence the presence or recession of the interproximal dental papilla between maxillary anterior teeth. A total of 102 interproximal sites of maxillary anterior teeth in 30 patients were examined. Tempbond™ mixed with barium sulfate was applied by a periodontal probe to the tip of the interproximal dental papillae and mucogingival junction. Periapical films using parallel technique were taken. The presence of interproximal dental papilla was determined on radiographs. If the tip of the interproximal dental papilla was at the base of the contact point, the papilla was recorded as being present. If not, the papilla was considered to be recessed. The radiographs were transferred into a computer and calibrated and measured with the image J software. The following factors were measured : [1] the distance from the base of the contact point to the bone crest. [2] The length of the interproximal dental papilla. [3] The width of keratinized gingiva. [4] The interdental distance. Results revealed that : [1] The number of interproximal dental papilla present had a significant decrease (p<0.001) when the distance from the contact point to bone crest increased. [2] The number of interproximal dental papilla present also had a significant decrease (p<0.05) when the interdental distance increased. [3] The distance from the contact point to the bone crest was the predominant factor, especially when it was 5 mm. Results also showed that this noninvasive method using radiographs is a reliable guideline for clinical evaluation of the interproximal dental papilla. To understand better the interaction of different factors associated with the presence of interproximal dental papilla, further studies are indicated. (J Taiwan Periodontol 13:269-278, 2008) Key words: contact area, alveolar bone crest, interproximal dental papilla, keratinized gingiva, interdental distance, radiography Received: June 15, 2008 Revised: August 20, 2008 Accepted: October 16, 2008 Address reprint requests and correspondence to: Dr. Min-chieh Chen, Department of Periodontics, ChangGung Memorial Hospital, No.222, Maijin Rd., Keelung, TAIWAN E-mail: [email protected] 278 J Taiwan Periodontol 13. No4. 2008 * *# * *# *# *# * # ( 13:279-290, 2008) (open flap debridement) (resective) (intra-osseous defect) Trombelli2 (regenerative) (bone graft) 1 (progression) (clinical attachment level) (periodontal probing depth) : 97 7 1 , : 97 9 8 , : 97 10 16 100 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 279 18 28 38 48 34 (intraoral autogenous bone) 3 autogenous 35 21 (extraoral bone) 4,5 (professional (decalcified freeze-dried bone allograft prophylaxis) DFDBA)6,7 (31-33) (bovine derived xenograft) (crowding) Bio-Oss® (donor site) (probing pocket depth) 8 9-10mm (300 ) 37 47 46 5mm (grade III furcation involvement) (bleeding on probing) 9 ( 7% 37.1 0.7% ) 10 17.8 0.5% 0.111 2.1 21 (secondary caries) Bio-Oss ® (hydroxyapatite DFDBA HA) 37 46 ( 47 (furcational bone loss) ) 12 13,14 (localized severe chronic periodontitis) 21 35 (Gingival index) 0.28 0.91 (Plaque index) 1.02 0.31 (Bleeding on probing) 8%( 280 ) 37 47 32.1% 8- J Taiwan Periodontol 13. No4. 2008 (initial periapical radiography) J Taiwan Periodontol 13. No4. 2008 281 37 Phase I periodontal therapy 47 45 46 282 47 (re-evaluation) 8mm 47 46 44-47 incision) 47 47 furcational bone loss (intracrevicular (distal extension incision) Bio-Oss® 47 J Taiwan Periodontol 13. No4. 2008 4-0 (nylon suture, 4-0) (modified mattress suture) 36 Phase I periodontal therapy 9 mm 37 37 37 36-37 Bio-Oss® 37 9mm ( 37 ) (barrier membrane) 46 4-0 (nylon suture, 4-0) (unpredictable) 46 J Taiwan Periodontol 13. No4. 2008 283 46 284 J Taiwan Periodontol 13. No4. 2008 (46-47) 45 (open flap debridement) 47 44 47 (ostectomy) (intracrevicular incision) 46 ( 47 ) 47 (distal extension incision) ( - ) (demineralized bovine xenograft 46 ( ) 4-0 Bio-Oss®) (nylon suture) (modified mattress suture) (osteoplasty) (odontoplasty) (tunnel preparation) ( 37 ( ) ( 47 ) - ) bone fill amoxicillin 46 7mm (Plaque index) O'Leary J Taiwan Periodontol 13. No4. 2008 (Gingival index) (O'Leary plaque index) (Bleeding on probing) 285 (500mg ) (0.12% chlorhexidine gluconate ) (guided tissue regeneration)18,19 (platelet-rich plasma) 20 Bio-Oss ® (supportive periodontal treatment) Chen21 ( (plaque control record) ) 37 Bio-Oss® ) 15% ( Bio-Oss® (animal model) 47 (bone remodeling) 3-4mm 22 (osseous level) ( ) 37 23 (osteoclastic 47 (bone fill) ( Bio-Oss® lacunae) (vascular channel) Bio-Oss® ) 24-26 27,28 26,29-31 23,32,33 Skoglund Oss® Bio- 6 Stavropoulos34,35 Bio-Oss® 10 25 8-9mm 37 3-4mm 47 46 15-17 3mm (forced eruption) 286 J Taiwan Periodontol 13. No4. 2008 46 (guided bone regeneration) 46 6. Bio-Oss® 7. 8. 9. 1. Papapanou PN, Wennstrom JL. The angular bony defect as indicator of further alveolar bone loss. J Clin Periodontol, 18:317-322, 1991. 2. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol, 29 Suppl 3:117-135, 2002. 3. Froum SJ, Thaler R, Scopp IW, Stahl SS. Osseous autografts. II. Histological responses to osseous coagulum-bone blend grafts. J Periodontol, 46:656-661, 1975. 4. Schallhorn RG, Hiatt WH. Human allografts of iliac cancellous bone and marrow in periodontal osseous defects. II. Clinical observations. J Periodontol, 43:67-81, 1972. 5. Dragoo MR, Sullivan HC. A clinical and histological evaluation of autogenous iliac J Taiwan Periodontol 13. No4. 2008 10. 11. 12. 13. bone grafts in humans. I. Wound healing 2 to 8 months. J Periodontol, 44:599-613, 1973. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol, 60:683-693, 1989. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part II. J Periodontol, 60:675-682, 1989. Cohen RE, Mullarky RH, Noble B, Comeau RL, Neiders ME. Phenotypic characterization of mononuclear cells following anorganic bovine bone implantation in rats. J Periodontol, 65:1008-1015, 1994. Gross JS. Bone grafting materials for dental applications: a practical guide. Compend Contin Educ Dent, 18:1013-1036, 1997. Benke D, Olah A, Mohler H. Proteinchemical analysis of Bio-Oss bone substitute and evidence on its carbonate content. Biomaterials, 22:1005-1012, 2001. Jensen SS, Aaboe M, Pinholt EM, HjortingHansen E, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants, 11:55-66, 1996. Valdre G, Mongiorgi R, Ferrieri P, Corvo G, Cattaneo V, Tartaro GP. [Scanning electron microscopy (SEM) and microanalysis (EDS) applied to the study of biomaterials for dental use]. Minerva Stomatol, 44:55-68, 1995. Nielsen IM, Ellegaard B, Karring T. Kielbone in healing interradicular lesions in monkeys. J Periodontal Res, 15:328-337, 1980. 287 14. Nielsen IM, Ellegaard B, Karring T. Kielbone in new attachment attempts in Humans. J Periodontol, 52:723-728, 1981. 15. Oxford GE, Quintero G, Stuller CB, Gher ME. Treatment of 3rd molar-induced periodontal defects with guided tissue regeneration. J Clin Periodontol, 24:464-469, 1997. 16. Kugelberg CF. Periodontal healing two and four years after impacted lower third molar surgery. A comparative retrospective study. Int J Oral Maxillofac Surg, 19:341-345, 1990. 17. Kugelberg CF, Ahlstrom U, Ericson S, Hugoson A, Thilander H. The influence of anatomical, pathophysiological and other factors on periodontal healing after impacted lower third molar surgery. A multiple regression analysis. J Clin Periodontol, 18:37-43, 1991. 18. Karapataki S, Hugoson A, Falk H, Laurell L, Kugelberg CF. Healing following GTR treatment of intrabony defects distal to mandibular 2nd molars using resorbable and non-resorbable barriers. J Clin Periodontol, 27:333-340, 2000. 19. Karapataki S, Hugoson A, Kugelberg CF. Healing following GTR treatment of bone defects distal to mandibular 2nd molars after surgical removal of impacted 3rd molars. J Clin Periodontol, 27:325-332, 2000. 20. Sammartino G, Tia M, Marenzi G, di Lauro AE, D'Agostino E, Claudio PP. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J Oral Maxillofac Surg, 63:766-770, 2005. 288 21. Chen CC, Wang HL, Smith F, Glickman GN, Shyr Y, O'Neal RB. Evaluation of a collagen membrane with and without bone grafts in treating periodontal intrabony defects. J Periodontol, 66:838-847, 1995. 22. Thaller SR, Hoyt J, Dart A, Borjeson K, Tesluk H. Repair of experimental calvarial defects with Bio-Oss particles and collagen sponges in a rabbit model. J Craniofac Surg, 5:242-246, 1994. 23. Skoglund A, Hising P, Young C. A clinical and histologic examination in humans of the osseous response to implanted natural bone mineral. Int J Oral Maxillofac Implants, 12:194-199, 1997. 24. Hutchens LH, Jr. The use of a bovine bone mineral in periodontal osseous defects: case reports. Compend Contin Educ Dent, 20:365378, 1999. 25. Richardson CR, Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL. Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Clin Periodontol, 26:421-428, 1999. 26. Scheyer ET, Velasquez-Plata D, Brunsvold MA, Lasho DJ, Mellonig JT. A clinical comparison of a bovine-derived xenograft used alone and in combination with enamel matrix derivative for the treatment of periodontal osseous defects in humans. J Periodontol, 73:423-432, 2002. 27. Camargo PM, Lekovic V, Weinlaender M, et al. A controlled re-entry study on the effectiveness of bovine porous bone mineral J Taiwan Periodontol 13. No4. 2008 used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans. J Clin Periodontol, 27:889-896, 2000. 28. Paolantonio M, Scarano A, Di Placido G, Tumini V, D'Archivio D, Piattelli A. Periodontal healing in humans using anorganic bovine bone and bovine peritoneumderived collagen membrane: a clinical and histologic case report. Int J Periodontics Restorative Dent, 21:505-515, 2001. 29. Lekovic V, Camargo PM, Weinlaender M, Nedic M, Aleksic Z, Kenney EB. A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. J Periodontol, 71:1110-1116, 2000. 30. Velasquez-Plata D, Scheyer ET, Mellonig JT. Clinical comparison of an enamel matrix derivative used alone or in combination with a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Periodontol, 73:433-440, 2002. 31. Pietruska MD. A comparative study on the J Taiwan Periodontol 13. No4. 2008 32. 33. 34. 35. use of Bio-Oss and enamel matrix derivative (Emdogain) in the treatment of periodontal bone defects. Eur J Oral Sci, 109:178-181, 2001. Schlegel AK, Donath K. BIO-OSS--a resorbable bone substitute? J Long Term Eff Med Implants, 8:201-209, 1998. Piattelli M, Favero GA, Scarano A, Orsini G, Piattelli A. Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans. Int J Oral Maxillofac Implants, 14:835-840, 1999. Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T. Deproteinized bovine bone used as an adjunct to guided bone augmentation: an experimental study in the rat. Clin Implant Dent Relat Res, 3:156165, 2001. Stavropoulos A, Kostopoulos L, Nyengaard JR, Karring T. Fate of bone formed by guided tissue regeneration with or without grafting of Bio-Oss or Biogran. An experimental study in the rat. J Clin Periodontol, 31:30-39, 2004. 289 Treatment of distal circumferential bony defects around the mandibular secondary molars with demineralized bovine xenograft - A case report Yu-Hsiang Chou* Kai-Fang Hu* Kun-Yen Ho*# Yi-Min Wu *# Chi-Cheng Tsai*# Ya-Ping Ho*# *Kaohsiung Medical University, Chung-Ho Memorial Hospital, Division of Periodontology #Faculty of Dentistry, College of Dental Medicine, Kaohsiung Medical University Treatment of deep circumferential bony defects around the mandibular secondary molars is a great challenge to periodontist. The morphology of the bony defect, the amount of the keratinized gingiva, the depth of the vestibule, and the accessibility for instrumentation are considered as important factors associated with the clinical outcome of treatment. Many treatment modalities with disparate results had been reported. We provide a case report that had distal circumferential bony defects around her bilateral mandibular secondary molars. Demineralized bovine xenograft was grafted into the bony defects after open flap debridement and thorough root planing. The clinical outcome of the surgery was satisfied as evaluated by clinical examination including probing depth, attachment level and radiographic bone fill. In conclusion, the findings of the present case, although based on a small number of observations, suggested that the enhanced clinical result in the treatment of circumferential defects in consequence of using demineralized bovine xenograft. Additional studies in a larger number of patients are needed to determine the predictability of the treatment modality in longevity. (J Taiwan Periodontol 13:279-290, 2008) Key words: demineralized bovine xenograft mandibular secondary molar circumferential defect Received: July 1, 2008 Revised: September 8, 2008 Accepted: October 16, 2008 Address reprint requests and correspondence to: Dr. Ya-Ping Ho, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Division of Periodontology No.100 , Tzyou 1st Road Kaohsiung 807 , TAIWAN E-mail:[email protected] 290 J Taiwan Periodontol 13. No4. 2008 (idiopathic thrombocytopenic purpura) 13,000/ L ( 13:291-299, 2008) (idiopathic thrombocytopenic purpura ITP) (1) (thrombocytopenia) Willebrand's disease 62 (2)von 56 (3) 1 : 97 7 25 , :97 9 10 , :97 10 2 235 2F E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 291 2007 3 1 CBC 2~3 33 APTT 13,000/ 47 3 L 450,000/ L Hb 11.0 APTT Hct 33.0 ( ( ) ) ( ) ( ( 32 3 ) X ) 2 3 9,000/ ) ( 292 PT 1 150,000/ L 32 DC X ( 2 L ) 25 27 33 J Taiwan Periodontol 13. No4. 2008 ( ( ) 3 19 4 Urobilinogen 10 ) 2007 28 6 7 WBC Creatinine ( ( J Taiwan Periodontol 13. No4. 2008 5 ) ) 293 CBC DC HE PT APTT 3 1 Sample condition Accetable - - RBC count 3.89 3.5 ~ 9.1 103/ L WBC count 6.6 3.8 ~ 4.9 106/ L Hb 11.0 12.0 ~ 15.0 g/dL Hct 33.0 35.0 ~ 44.0 % MCV 84.8 83.8 ~ 98.0 fL MCH 28.2 28.4 ~ 33.8 pg MCHC 33.3 33.4 ~ 35.2 g/dL Platelet count 13 157 ~ 377 RDW 13 11.7 ~ 14.9 % Neutrophil-S 60.9 39.4 ~ 72.6 % Lymphocyte 29.7 21 ~ 51 % Monocyte 7.9 4.60 ~ 11.0 % Eosinophil 1.1 0.4 ~ 7.6 % Basophil 0.4 <1.3 % PT 10.4 9.5 ~ 12.0 sec I.N.R 0.93 - - Control 13 - sec APTT 47 25-36 sec 103/ L -ocytes) 7 2 10 (phagocytic cells) 150,000/ (megakary 294 450,000/ L L 150,000/ L J Taiwan Periodontol 13. No4. 2008 ( tapering dose) (96 ) 2 Prednisolone 5mg 12 QD 7 3 12 Prednisolone 5mg 7 QD 7 4 9 Prednisolone 5mg 3 QD 21 4 30 Prednisolone 5mg 3 QD 28 5 28 Prednisolone 5mg 1 QD 28 6 25 Prednisolone 5mg 1 QD 7 8 6 Prednisolone 5mg 1 QOD 28 9 3 Prednisolone 5mg 1 QOD 28 3 (96 ) Platelet count(/ L) 3 01 13,000 3 02 9,000 3 19 62,000 4 30 40,000 5 28 157,000 6 25 186,000 8 06 206,000 11 06 299,000 6 7 1 (thrombocytopenia)3 100,000/ L 50,000/ 100,000/ L (thrombocytopenic purpura) L 50,000/ (petechiae) L (hemorrhagic vesicles) 20,000/ J Taiwan Periodontol 13. No4. 2008 L 4 295 6 7 6 7 (1) (2) (3) 1,3,5 (hemolytic uremic syndrome HUS) (1) (decreased bone marrow (thrombotic thrombocytopenic purpura TTP) (disseminated intravascular coagulation production) DIC) (2) (thiazide diuretics) (splenic sequestration) (heparin)1 (idiopathic thrombocytopenic purpura) (portal 3,6,7 hypertension) (leukemia) (3) (lymphoma) (accelerated destruction of platelets) 296 J Taiwan Periodontol 13. No4. 2008 13,000/ 1 3 20 40 L BT(bleeding time) 1 BT Hb Hct (coombs' test) 1,3 (glucocorticoid) 20,000/ 20,000 50,000/ L L (prednisolone 1~2mg/kg/day) (ASH) 3 2/3 60 1 ITP L3 50,000/ 10 prednisolone 60mg 40 (tapering dose) (myelodysplasia )3 prednisolone 5mg 60mg 35mg 3 62,000/ 40,000 L 5 TTP HUS 19 4 11,12 30 28 DIC DIC 13 (IVIG) (anti-RHD)1,3 PT APTT ITP 56 60mg TTP HUS prednisolone 1 prednisolone 1761 ITP 25% 5% 8 60 9 ITP J Taiwan Periodontol 13. No4. 2008 297 7. Fotos PG, Graham WL, Bowers DC, Perfetto SP. Chronic autoimmune thrombocytopenic 14 purpura. A 3-year study. Oral Surg Oral Med Oral Pathol, 55(6):564-7, 1983. 8. George JN, el-Harake MA, Raskob GE. Chronic idiopathic thrombocytopenic purpura. N Engl J Med, 331(18):1207-11, 1994. 9. Frederiksen H, Schmidt K. The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood, 94(3):90913, 1999. 10. George JN, Woolf SH, Raskob GE. Idiopathic 1. Braunwald E, Fauci SA, Kasper LD, Hauser thrombocytopenic purpura: a guideline for LS, Longo LD, Jameson LJ. Harrison's diagnosis and management of children and Principles of Internal Medicine. 15th ed, adults. American Society of Hematology. McGraw-Hill Co, U.S., pp.358, 745-747, Ann Med, 30(1):38-44, 1998. 2001. 11. Colman RW, Marder VJ, Clowes AW, Geroge 2. Guyton CA, Hall EJ. Text Book of Medical JN, Goldhaber SZ. Hemostasis and Thrombosis: Physiology. 10th ed, W.B. Saunders Co, U.S., Basic Principles and Clinical Practice. 5th ed, pp.419-420, 2000. Lippincott Williams & Wilkins Co., U.S., 3. Lichtman AM, Beutler E, Kipps JT, pp.1613, 2006. Seligsohn U, Kaushansky K, Prchal TJ. 12. Fenner M, Frankenberger R, Pressmar K, Williams Hematology. 7th ed, McGraw-Hill John S, Neukam FW, Nkenke E. Life- Co, U.S., pp.1749-1770, 2006. threatening thrombotic thrombocytopenic 4. Carranza AF, Newman GM. Clinical purpura associated with dental foci. Report of Periodontology. 8th ed, W.B. Saunders Co, two cases. J Clin Periodontol, 31(11):1019- U.S., pp.198, 1996. 23, 2004. 5. Neville WB, Damm DD, Allen MC, Bouguot 13. J. Oral & Maxillofacial Pathology, 2nd ed, W.B. Saunders Co, U.S., pp.508-509, 2001. pp.102,113, 2005. 6. Ripamonti U, Petit JC, Penfold G, Lemmer J. 14. Ripamonti U, Petit JC, Penfold G, Lemmer J. Periodontal manifestations of acute autoimmune Periodontal manifestations of acute autoimmune thrombocytopenic purpura. A case report. J thrombocytopenic purpura. A case report. J Periodontol, 57(7):429-32, 1986. Periodontol, 57(7):429-32, 1986. 298 J Taiwan Periodontol 13. No4. 2008 Gingival bleeding disorders and idiopathic thrombocytopenic purpura: Case report Yi-Hung Lin Kuo-Yang Tsai Chia-Ching Chen Jen-Hsin Hsu Chun-Tai Lu Changhua Christian Hospital Clinically, we need to exam the oral condition of patients with gingival bleeding disorders. Otherwise, we should consider their systemic diseases, especially the problems of hemostasis which is the major cause of gingival bleeding disorders. Once disorders of hemostasis was suspected, we need to arrange blood tests and consult relative specialists to make sure our diagnosis. The case was idiopathic thrombocytopenic purpura which caused gingival bleeding. Except the patient s oral symptoms, patechiae was noted on the skin of face and extremity, and the platelet count was only 13,000/ L. After the treatment with steroid prescribed by the hemo-oncologist, the platelet count increased to normal range, and gingival bleeding disorders also disappeared. (J Taiwan Periodontol 13:291-299, 2008) Key words: gingival bleeding disorders, idiopathic thrombocytopenic purpura, thrombocytopenia Received: July 25, 2008, Revised: September 10, 2008, Accepted: October 2, 2008 Address reprint requests and correspondence to: Dr. Lu Chun-Tai, Dental Department, Changhua Christian Hospital. 135 Nanhsiao Street, Changhua 500, TAIWAN E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 299 300 J Taiwan Periodontol 13. No4. 2008 1,3 2,3 1,3 1,3 1,3 1 2 3 #16 #14 #15 #16 X ( 13:301-314, 2008) 2 3,4,5 6 1 : 97 6 13 , : : 97 9 4 , : 97 10 24 199 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 301 #13 95 7 3 #14 #26 #44 #42 #31 95 #23 9 #11 #12 #13 #21 #22 #23 #24 #25 #32 #31 7,8 (reline) (rebase) #41 #42 #43 (occlusal adjustment) ( 94 ( ) #14 #26 #31 #44 #13 #12 #11 #21 #22 #23 #24 #31 #32 #33 #34 #42 #43 #14 #15 #16 #37 #41 #44 #24 #25 #17 #26 #45 #31 #46 #11 #25 #13 #12 #21 #43 #42XX#32#33 #35 #27 #36 #47) #22 #23 #13 #23 #24 #25 #31 #42 #43 #23 #42 #35 #36 302 #37 #15 #16 #17 #41 #45 #46 #47 J Taiwan Periodontol 13. No4. 2008 (#46) (#45) 95 7 #44 (#44) #45 #46 4 x10mm 3I (Implant Innovations, Inc.) 95 7 #44 #45 #46 4x10mm 3I (Implant Innovations, Inc.) ( J Taiwan Periodontol 13. No4. 2008 ) ( ( ) ) 303 (#35) (#36) 95 8 #35 #36 (#37) #37 95 #35 4X10mm 3I ( 8 (healing #37 abutment) (Implant Innovations, Inc.) ) 96 2 ( 95 304 #36 4 x10mm 11 ( ) ( ) ) #16 #14 #15 6mm J Taiwan Periodontol 13. No4. 2008 (healing abutment) (healing abutment) (#16) (#15) #14 #15 #16 J Taiwan Periodontol 13. No4. 2008 4 X 11.5 mm (#14) #14 #15 #16 305 96 9 97 2 X #14 #15 #16 (osteotome) (sinus elevation) macroporous TM biphasic calcium phosphate (MBCP ) (Triosite, ( Zimmer Co.,Rungis,France) 97 2 #14 #15 #16 #14 #15 #16 (Implant Innovations, Inc.) 4 X 11.5 mm 3I ( ( 306 ) ) 97 #14 #15 #16 97 ) ) 4 ( 16 6 ( ) J Taiwan Periodontol 13. No4. 2008 97 X 6 ( ) 9 J Taiwan Periodontol 13. No4. 2008 307 97 6 97 6 10,11,12 X 80% 9 13 (recent myocardial infarction) 18 (valvular prostheses) 308 (severe J Taiwan Periodontol 13. No4. 2008 renal disorder) (treatment - resistant diabetes) (physical and mental state) (ethical 19 considerations) (generalized secondary osteoporosis) ? (chronic or severe alcoholism) 19 (treatment - resistant osteomalacia) (active radiotherapy) (severe hormone deficiency) (drug addiction) (motivation) (desire) 14 20 20 D(Vitamin D) estrogen Dao (repair) 15 ? (root form) 16 21 17 Khadivi Lindhe 18 22,23 ? (realistic need) (feasible need) 1.5%24 (self-perceived need) (expressed demand) J Taiwan Periodontol 13. No4. 2008 25,26,27 309 80 X 0.4mm 1mm 36 1.2mm 25 207 (long contact 37 point) 10 28,29 17,24 22 24 25,28,29,31,32,38,39 30 28,31 25, 31, 32 6,33 (implant retained and supported prostheses) (Tongue hyperactivity) (centric occlusion position) 24,28 (Freedom in centric) 40 (Restorative space) 34 5mm (Implant supported) (implant- retained prostheses) (interarch distance) (self-esteem) 17 3 (vertical alveolar ridge augmentation) 4 41,42,43 6 2 1 2 (onlay bone grafts) (distraction 1 4 6 17 implant ) 35 310 J Taiwan Periodontol 13. No4. 2008 Aspen Publication. 40 3. Osterberg T, Mellstrom D. Tobacco smoking A major risk factor for loss of teeth in three 43,44 70-year-old cohorts. Community Dent Oral 43,44 Epidemiol, 14 367-370, 1986. 4. Osterberg T, Carlsson GE, Mellstrom D, Sundh W. Cohort comparison of dental status in the adults Swedish population between 1975 and 1981.Community Dent Oral Epidemiol, 19 (distal free end) 195-200, 1991. 5. Hugosson A, Koch G, Bergendahl T. Oral health of individuals aged 3-80 years in Jonkoping,Sweden, in 1973 and 1983.II. A review of clinical and radiographic findings. Swed Dent J, 10 175-194, 1986. 6. Nordenram A, Landt H. Oral implants in X aged patients. In Holm Pedersen P, Loe H. Geriatric Dentistry.Copenhagen,Munksgaard, PP 353-361,1986. 7. Agerberg G, Carlsson GE. Chewing ability in relation to dental and general health analysis of data obtained from a questionnaire. Odontol Scand , 39 147-153, 1981. 8. Ettinger RL. Diet, nutrition and masticatory ability in a group of elderly edentulous patients. Aust Dent J, 18 12-9, 1973. 9. Jabbari Y AI ,.Nagy W N, Iacopino A M. Implant dentistry for geriatric patients 1. Bailey R, Gueldner S, Ledikwe J, SmiciklasWright H. The Oral Health of Older Adults. An Interdisciplinary Mandate. J Gerontol Nurs, 31 11-17, 2005. 2. Martin, W. Oral health in the elderly. Geriatric nutrition.(2nd ed.) 1999. Gaithersburg, MD. J Taiwan Periodontol 13. No4. 2008 A review of the literature .Quintessence Int, 34 281-285, 2003. 10. Henriksson PA, Wallenius K. The mandible and osteoporosis.1 A quantitative comparison between the mandible and the radius. J Oral Rehabil, 1 67-74, 1974. 311 11. Roberts E, Gonsalves M. Aging of bone tissue. In Holm-Pedersen P, Loe H. Geriatric Dentistry. Copenhagen, Munksgaard PP 8394, 1986. 12. Holm-Pedersen P. Studies on healing capacity in young and old individuals (thesis). Copenhagen Munksgaard, 1973 13. Ship JA, Chavez EM. Management of systemic diseases and chronic impairments in older Adults Oral health considerations. Gen Dent, 48 557-558, 2000. 14. Chanavaz M. Patient screening and medical evaluation for implant and prosthetic surgery. J Oral Implant, 24 222-229, 1998. 15. Dao TT, Anderson JD, Zarb GA. Is osteoporosis a risk factor for osseointegration of dental implants? Int J Oral Maxillofac Implants, 8 133-44, 1993. 16. Shernoff A, Colwell JA, Bingham SF. Implants for type II diabetic patients Interim report. Implant Dent, 3 183-185, 1994. 17. Zarb GA, Schmitt A. Osseointegration for elderly patients The Toronto study. J Prosthet Dent, 72 559-568, 1994. 18. Khadivi V. The impact of cardiovascular disease on the success rate the surgical phase of the osseointegration technique (Thesis). Toronto Faculty of Dentistry, University of Toronto, 1993. 19. Holm-Pedersen P, Vigild M, Nitschke I, Berkey DB. Dental care for aging populations in Denmark,Sweden,Norway,United Kingdom, and Germany. J Dent Edu, 69 987-997, 2005. 20. Muller F, Wahl G, Fuhr K.Age-related satisfaction with complete dentures, desire for 312 improvement and attitude to implant treatment. Gerodontology,11 7-12, 1994. 21. Zarb G, Albrektsson T. Osseointegrated A requiem for the periodontal ligament? Int J Periodontics Restorative Dent, 11 88-91, 1991. 22. Lindhe J, Socransky SS, Nyman S, Westfelt E, Haffajee A.Effect of age on healing following periodontal therapy. J Clin Periodontol, 12 774-87, 1985. 23. Holm-Pedersen P. Influence of age on tissue healing. In Worthington P, Branemark P-I, eds. Advanced osseointegration surgery. Chicago Quintessence Publishing, PP 4756, 1992. 24. Zarb GA, Schmitt A. The longitudinal clinical effectiveness of osseointegrated dental implants The Toronto study Part III Problems and complication encountered.J Prosthet Dent, 64 185-194, 1990. 25. Torsten Jemt. Implant Treatment in Elderly Patients. Int J of Prosthodont, 6 456 - 461, 1993. 26. Zarb G, Schmitt A. Terminal dentition in elderly patients and implant therapy alternatives. Int Dent J, 40 67-73, 1990. 27. Kondell PA , Nordenram A, Landt H. Titanium implants in the treatment of edentulousness. The influence of patient's age on prognosis. Gerodontics, 4 280-284, 1988. 28. Zarb GA, Schmitt A. The longitudinal clinical effectiveness of osseointegrated implants The Toronto study Part I Surgical results. J Prosthet Dent, 63 451-457, 1990. 29. Zarb GA, Schmitt A. Implant therapy alternatives for geriatric edentulous patients. Gerodontology J Taiwan Periodontol 13. No4. 2008 , 10 28-32, 1993. 30. George A. Zarb, Adrianne Schmitt. Osseointegration immediately placed dental implants-a case report. Int J Periodontics Restorative Dent, The Toronto study. J 22 451-461, 2002. 38. Friberg B, Jemt T, Lekholm U. Early failures of 4641 consecutively placed Branemark dental implants. A study from stage one surgery to connection of the completed prostheses. Int for elderly patients Prosthet Dent, 72 559-68, 1994.. 31. Adell R, Lekholm U, Eriksson B, Branemark P-I, Jemt T. A long-term follow-up study of osseointegrated implants in the treatment of the totally edentulous jaw. Int J Oral Maxillofac Implants, 5 347-350, 1990. 32. van Steenberghe D, Quirynen L, Callberson M, Demanet M. A prospective evaluation of 697 consecutive intra-oral fixtures ad modum Branemark in rehabilitation and edentulism. J Head Neck Pathol, 6 53-58, 1987. 33. Lewis GR. Aging and the accuracy of jaw muscle control. Gerodontology, 7 139-144, 1988. 34. Norton MR .Single -tooth implant-supported restorations. Planning for an aesthetic and functional solution.Dental update, 28 170175, 2001. 35. Feichtinger M, Gaggl A, Schultes G, Karcher H. Evaluation of distraction implants for prosthetic treatment after vertical alveolar ridge distraction A clinical investigation.Int J Prosthodont, 16 19-24, 2003. 36. Salama H, Salama MA, Garber D,Adar P. The interproximal height of bone a guidepost to predictable aesthetic strategies and soft tissue contours in anterior tooth replacement, Prac Periodontics. Aesthet Dent, 10 1131-1141, 1998. 37. Hureler MB, Zuhr O,Schenk G,Schoberer J Oral Maxillofac Implants, 6 142-146, 1991. 39. Cox JF, Zarb GA. The longitudinal clinical efficacy of osseointegrated dental implants A 3-year report. Int J Oral Maxillofac Implants, 2 91-100, 1987. 40. Mericske-Stern R. Overdentures with roots or implants for elderly patients A comparison. J Prosthet Dent, 72 543-550, 1994. 41. Muller F, Wahl G, Fuhr K. Age-related satisfaction with complete dentures, desire for improvement and attitude to implant treatment. Gerodontology, 11 7-12, 1994. 42. Van den Bergh LPA, ten Bruggenkata CM, Tuinzing DB. Preimplant surgery of the bony tissue. J Prosthet Dent, 80 175-183, 1998. 43. Cordioli G, Majzoub Z, Castanga S. Mandibular overdentures anchored to single implants A five-year prospective study. J Prosthet Dent, 78 159-165, 1997. 44. Krennmair G, Ulm C. The symphyseal single tooth implant for anchorage for a mandibular complete denture in geriatric patients A clinical report.Int J Oral Maxillofac Implants, 16 98-104, 2001. U,Wachtel H,Bolz W.Distraction Osteogenesis A treatment tool to improve baseline conditions for esthetic restorations on J Taiwan Periodontol 13. No4. 2008 313 Multiple implants treatment in an elderly patient - A case report Yen-Li Wang1,3 Lin-Ming Yuh2,3 Whei-Lin Pan1,3 Yuh-Ren Ju1,3 Chiu-Po Chan1,3 1Periodontal department, Dental section, Taipei Chang Gung Memorial Hospital 2Prosthodontic department, Dental section, Taipei Chang Gung Memorial Hospital 3Chang Gung University With the transition of population structure, there is a marked increase in the ratio of elderly people in Taiwan society. The elderlies nowadays keep more natural teeth than before. However, with the request for better life quality, the conventional removable prostheses no longer satisfy their needs of esthetics and function, and thus osseointegrated implants and fixed prostheses are more commonly considered for elderly patients. To improve the efficacy of treatment and the satisfaction of elderly patients, it is necessary to make a comprehensive treatment plan, which takes into consideration of the patient's physical and psychological conditions, the bone condition, the possible risk of surgery, and the adaptation after surgery. In this report, an 83-year-old male patient strongly requested to replace the posterior missing teeth with fixed prostheses. After detailed evaluation, the lower bilateral and upper right posterior edentulous areas were all restored with implants. In general, the patient was in good health without any major systemic disease. Six implants were placed at lower bilateral posterior areas. Sinus lifting procedure was done at #16 area , and three implants (#14, #15, #16) were placed simultaneously. Full mouth prosthetic treatment was completed and now the patient is under regular maintenance. Radiographic and clinical examinations after 16 months since the last implant placement showed that the implants were in good condition. In addition, the patient was very satisfied with both the esthetics and function of the prostheses. This case report reveals that under meticulous preoperative evaluation and treatment, elderly patients can adapt to implant rehabilitation well , and attain satisfying results. (J Taiwan Periodontol 13:301-314, 2008) Key words: elderly patients, implant, implant-supported prostheses Received: June 13, 2008 Revised: September 4, 2008 Accepted: October 24, 2008 Address reprint requests and correspondence to: Dr. Chiu-Po Chan, Department of periodontics, Chang Gung Memorial Hospital, No.199, Tung Hwa N. Road, Taipei, TAIWAN. E-mail [email protected] 314 J Taiwan Periodontol 13. No4. 2008 (insufficient interarch space) (occlusal vertical dimension) (crown lengthening procedure) ( 13:315-325, 2008) (Orthognathic surgery)3 (4) (increase occlusal vertical dimension) 1,2 : (1) 1,2 (2) (crown lengthening procedure) (orthodontic treatment) : 97 9 30 , :97 10 (3) 25 , :97 11 15 901 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 315 (overjet) 3mm 3mm X ( ) / 1.5/1 1/3 #13 #24 #48 #24 32 ( ) #16 #18 #23 #38 #46 #47 #11 #25 #15 #15 #26 #12 #14 #28 #34 #36 #15 #27 #33 #17 #17 #35 #45 (supraeruption) #33 #21 #15 #13 #17 #22-24 #35 #21 #27 #37 #44 #33-35 #38 (Angle's Class I relationship) (overbite) 316 5mm J Taiwan Periodontol 13. No4. 2008 (fixed partial dentures) 4 (fixed partial dentures combined implant prostheses) : (2) (1) (oral hygiene instruction) (2) #37 (3) 24 #33-35 #22- (resin restoration) #37 (4) (provisional removable partial denture) (5) #13 #15 #21 #22 #45 #24 #33 #35 #48 (6) (7) #24 #27 #27 #33 #36 #21-25 #13 #35 #46 #22-27 #15 #21 (8) #47 #48 #46 #33 #35 #45 #13 #15 #21 #22 #24 #27 (9) #33-35 #36 (3) #45 (4) ( ) #47 : (5) #13 #15 #21 #24 #27 #33 #35 ( ) (1) (post&core) (6) #48 #36 #46 #47 (7) (porcelain-fused-to-metal) (gingival margin) ( ( / J Taiwan Periodontol 13. No4. 2008 1/1 ) -25 #22-27 #33-35 #36 #46 ) #21 #45 #47 317 36 318 46 47 3 4.1x12mm SP Straumann ITI J Taiwan Periodontol 13. No4. 2008 (anchorage) (miniscrew implant) ( ) (intrusion) (8)11 ( ) ( J Taiwan Periodontol 13. No4. 2008 ) 319 5:(1) (cervical perforation) (2) (3) 3mm 6,7 (biological width) Herrero8 #15 / 1/1 11 (Restorative-driven procedure) 11 320 (marginal bone level) J Taiwan Periodontol 13. No4. 2008 81% 79% 86% 11 0.6mm (Ferrule effect) Libman 9 5mm Nicholls12 1.5mm ( / / Shillingburg 13 (forced eruption) 10 / 1 ( ) 14 3mm 15 GP 1 ( ) 3mm ) ( ) 77% 76% 85% J Taiwan Periodontol 13. No4. 2008 321 Tooth number 13 12 11 21 22 23 Length 10 10 11 10 8.5 9 Width 8.5 7 9 9 7 8.5 W/L 85% 70% 87% 90% 82% 84% Tooth number 13 12 11 21 22 23 Length 11 9.5 11 11 9.5 11 Width 8.5 7 9 9 7 8.5 W/L 77% 74% 87% 87% 74% 77% DeLuca22,23 3mm ( 25cy) 16 4mm (Late implant failure and / 1 marginal bone loss) 18 19 20 20 21 / 1. Studsukh T-T. Treatment of patient with severely worn dentition: A clinical report. J Prosthodont, 16:219-225, 2007. 322 J Taiwan Periodontol 13. No4. 2008 2. Phuong D. Doan, Gary R. Goldstein. The use 2002 of a diagnostic matrix in the management of 12. Libman W, Nicholls J. Load fatigue of teeth the severely worn dentition. J Prosthodont, restored with cast post and core and complete 16:277-281, 2007. crowns. Int J Prosthodont, 8:155-161, 1995. 3. Mopsik ER, Buck RP, Connors JO, Watts LN. 13. Shillingburg HT, Hobo S, Whitsett LD. Surgical intervention to reestablish adequate Fundamentals of fixed prosthodontics. 2nd intermaxillary space before fixed or ed. Chicago: Quintessence Publishing Co, 19- removable prosthodontics. J Am Dent Assoc, 20:79-86, 1991. 95(5):957-60, 1977. 4. Walker M, Hansen P. Template for surgical crown lengthening: Fabrication technique. J Prosthodont, 7:265-267, 1998. 14. Sorenson J, Martinoff J. Clinically significant factors in dowel design. J Prosthet Dent, 52:28-35, 1984. 15. Kvist T, Rydin R, Reit C. The relative 5. Simon Y, Sebastiano A. Crown legthening: frequency of periapical lesions in teeth with Basic principles, indications, techniques and root canal retained post. J Endo, 15:578-580, clinical case report. NY state Dent J, 1989. 70(8):30-6, 2004. 16. Goodacre C, Campagni W, Aquilino S. Tooth 6. Bragger U, Lauchenauer D, Lang NP. preparations for complete crowns: An art Surgical crown lengthening of the clinical form based on scientific principles. J Prosthet crown. J Clin Periodontol, 19:58-63, 1990. Dent, 85:363-376, 2001. 7. Herrero F, Scott JB, Maropis PS, Yukna RA. 17. Heasman L, Stacey F, Preshaw PM, Clinical comparison of desired versus actual McCracken GI, Hepburn S, Heasman PA. amount of surgical crown lengthening. J The effect of smoking on periodontal Periodontol, 66:568-571, 1995. treatment response: a review of clinical 8. Wagenberg BD, Eskow RN, Langer B. Exposing adequate tooth structure for restorative dentistry. Int J Perio Res Dent, 5:321-332, 1989. 9. Gargiulo A, Wentz F, Orban B. Dimensions and relations of the dentogingival junction in evidence. J Clin Periodontol, 33:241-253, 2006. 18. Georgia K. Johnson and Margaret Hill. Cigarette smoking and the periodontal patient. J Periodontol, 75:196-209, 2004. 19. Preber H, Bergstrom J. Effect of cigarette humans. J Periodontol, 32:261-267, 1961. smoking on periodontal healing following 10. David A, Raphael P, Barry M. Restoring teeth surgical therapy. J Clin Periodontol, following crown lengthening procedures. J Prosthet Dent, 65:62-65, 1991. 17(5):324-328, 1990. 20. Trombelli L, Scabbia A: Healing response of 11. Magne P, Belser U. Chapter 2 in bonded gingival recession defects following guided porcelain restorations. Quintessence Pub. Co. tissue regeneration procedures in smokers J Taiwan Periodontol 13. No4. 2008 323 and non-smokers. J Clin Periodontol, 24:529533, 1997. 21. Tonetti M. S, Pini Prato G, Cortellini P. Effect of cigarette smoking on periodontal healing following GTR in infrabony defects. J Clin Periodontol, 22:229-234, 1995. 22. DeLuca S, Habsha E, Zarb G. The Effect of 324 Smoking on Osseointegrated Dental Implants. Part I: Implant Survival. Int J Prosthodont, 29:491-498, 2006. 23. DeLuca S, Zarb G. The Effect of Smoking on Osseointegrated Dental Implants. Part II: Peri-implant Bone Loss. Int J Prosthodont, 29:560-566, 2006. J Taiwan Periodontol 13. No4. 2008 The application of crown lengthening procedure and elevation of occlusal plane to create the interarch space: A case report Chih-Wen Cheng, Chun-Jung Chen, Lian-Ping Mau* , Jui-Chung Chang** , Iok-Chao Pang** Dental Department, Chi Mei Medical Center, Liouying campus *Periodontic Division, Dental Department, Chi Mei Medical Center, Tainan ** Prosthodontic Division, Dental Department, Chi Mei Medical Center, Tainan It is difficult and complicated to restore a case with insufficient interarch space. The critical factor of treatment depends upon patient s condition. Therefore, a comprehensive oral examination for treatment planning is very important. The case reports a female patient who has an insufficient interarch space due to partial edentulism for a long period of time. Under the prerequisite of maintaining the original occlusal vertical dimension, crown lengthening procedures were performed on all upper teeth and lower posterior teeth. To create sufficient interarch space through combination with elevation of occlusal plane, upper arch was restored with fixed partial dentures and lower arch was restored with fixed partial dentures and implant prostheses. This simplified method combined with crown lengthening procedure and occlusal rehabilitation, the problems of insufficient interarch space and gummy smile were resolved without neither orthodontic treatment nor alteration of the occlusal vertical dimension. For cases with insufficient interarch space, the preprosthetic treatment planning and cast analysis are the key elements of success.(J Taiwan Periodontol 13:315-325, 2008) Key words: crown lengthening procedure, insufficient interarch space, treatment planning Received: September 30, 2008, Revised: October 25, 2008, Accepted: November 15, 2008 Address reprint requests and correspondence to: Dr. Iok-Chao Pang, Dental Department, ChiuMei Medical Center 901 Chung-Hwa Road, Yung Kang City, Tainan 710, TAIWAN E-mail:[email protected] J Taiwan Periodontol 13. No4. 2008 325 326 J Taiwan Periodontol 13. No4. 2008 ( 13:327-337, 2008) pneumatization 1,2 Boyne : 97 7 17 , : : 97 8 16 , : 97 10 22 5 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 327 James 3 X 3cmx3cm 4-7 (retention cyst) Caldwell-Luc lateral window sinus lifting Cerasorb 8 Nicolaas M. 1997 SinboneHT 9 Epi-Guide Augmentin 375 mg (amoxicillin 328 J Taiwan Periodontol 13. No4. 2008 (A) Panoramic view (B) Sagittal view 500mg ) Schneiderian membrane X J Taiwan Periodontol 13. No4. 2008 329 (A)Panoramic view Caldwell-Luc lateral window sinus lifting MBCP PeriAid A Augmentin 375 mg 1.2 330 0.8 J Taiwan Periodontol 13. No4. 2008 ( B)Sagittal view A) 5 5 (B) 7 7 B J Taiwan Periodontol 13. No4. 2008 331 A)Panoramic view (B)Sagittal view 4-9 332 J Taiwan Periodontol 13. No4. 2008 seromucinous gland 15-19 1.4% 9.6%17,20 self-limited 38% (31%) 17.6%18 (29%)10 oroantral communication 21 8 15 11 12,13 14 sinus retention cyst X J Taiwan Periodontol 13. No4. 2008 333 7% 35%4,6,22-24 25 23,26 1. Löe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. Tooth mortality rates before 40 years of age. J Periodontal Res, 13:563- 572, 1978. 2. Laurell L, Romao C, Hugoson A. Longitudinal study on the distribution of proximal sites showing significant bone loss. J Clin Periodontol, 30:346-352, 2003. 3. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg, 38: 613-616, 1980. 334 J Taiwan Periodontol 13. No4. 2008 4. Jensen OT, Shulman LB, Block MS, Iacono VJ. Report of the sinus consensus conference of 1996. Int J Oral Maxillofac Implants, 13(Suppl.):5-45, 1998. 5. Tong DC, Drangsholt M, Beirne OR. A review of survival rates for implants placed in grafted maxillary sinuses using metaanalysis. Int J Oral Maxillofac Implants, 13:175-182, 1998. 6. Khoury F. Augmentation of the sinus floor with mandibular bone block and simultaneous implantation: A 6-year clinical investigation. Int J Oral Maxillofac Implants, 14: 557-564, 1999. 7. Hürzeler MB, Kirsch A, Ackermann KL, Quinones CR. Reconstruction of the severely resorbed maxilla with dental implants in the augmented maxillary sinus: A 5-year clinical investigation. Int J Oral Maxillofac Implants, 11: 466-475, 1996. 8. Devorah Schwartz-Arad, The Prevalence of Surgical Complications of the Sinus Graft Procedure and Their Impact on Implant Survival. J Periodontol, 75:511-516, 2004. 9. Nicolaas M. Maxillary Sinus Function After Sinus Lifts for the Insertion of Dental Implants. J Oral Maxillofac Surg, 55:936939, 1997. 10. Christian Beaumont: Prevalence of Maxillary Sinus Disease and Abnormalities in Patients Scheduled for Sinus Lift Procedures. J Periodontol, 76:461-467, 2005. 11. Druce HM: Diagnosis of sinusitis in adults: History, physical examination, nasal cytology, echo and rhinoscope. J Allergy Clin Immunol, 90:436, 1992. J Taiwan Periodontol 13. No4. 2008 12. Havas TE, Motbey JA, Gullane PJ. Prevalence of incidental abnormalities on computed tomographic scans of the paranasal sinuses. Arch Otolaryngol Head Neck Surg, 114:856859, 1988. 13.Kennedy DW, Zinreich SJ. The functional endoscopic approach to inflammatory sinus disease: Current perspectives and technique modifications. Am J Rhinol, 2:89-96, 1988. 14. Nicolaas M. Timmenga, Maxillary Sinusitis After Augmentation of the Maxillary Sinus Floor: A Report of 2 Cases. J Oral Maxillofac Surg, 59:200-204, 2001. 15. Paparella MM. Mucosal cyst of the maxillary sinus: diagnosis and management. Arch Otolaryngol, 77:650-670, 1963. 16. Gardner DG. Pseudocysts and retention cysts of the maxillary sinus. Oral Surg Oral Med Oral Pathol, 58: 561-567, 1984. 17. Ruprecht A, Batniji S, El-Neweihi E. Mucous retention cyst of the maxillary sinus. Oral Surg Oral Med Oral Pathol, 62:728-731, 1986. 18. Halstead CL. Mucosal cysts of the maxillary sinus: report of 75 cases. J Am Dent Assoc, 87:1435-1441, 1973. 19. Myall RW, Eastep PB, Silver JG. Mucous retention cysts of the maxillary antrum. J Am Dent Assoc, 89:1338-1342, 1974. 20. Rhodus NL. The prevalence and clinical significance of maxillary sinus mucous retention cysts in a general clinic population. Ear Nose Throat J, 69:82-87, 1990. 21. J Skladzien, J A Litwin. Maxillary sinus polyps secondary to dental extraction. J Laryngology Otology, 114: 350-253, 2000. 335 22.Kirsch A, Ackermann KL, Hurzeler MB, Hutmacher D. Sinus grafting with porous hydroxyapatite. In: Jensen OT, ed. The Sinus Bone Graft, 1st ed. Chicago: Quintessence Books, 79-94, 1999. 23.Ziccardi VB, Betts NJ. Complications of maxillary sinus augmentation. In: Jensen OT, ed. The Sinus Bone Graft, 1st ed. Chicago: Quintessence Books, 201-208, 1999. 24.Wannfors K, Johansson B, Hallman M, Strandkvist T. A prospective randomized 336 study of 1- and 2-stage sinus inlay bone grafts: 1 year follow-up. Int J Oral Maxillofac Implants, 15:625-632, 2000. 25. Buiter C: Endoscopy of the upper airways. Thesis. Amsterdam, The Netherlands, Exerpta Medica, 1976. 26. Regev E, Smith RA, Perrot DH, Porgel MA. Maxillary sinus complications related to endosseous implants. Int J Oral Maxillofac Implants, 10:451-461, 1995. J Taiwan Periodontol 13. No4. 2008 Sinus augmentation into sites with mucosal pathologies of maxillary sinus Te-Chou Wang Suefang Kung * Section of Periodontics, Department of Dentistry, Chang Gung Memorial Hospital *Section of Periodontics, Department of Dentistry, Chang Gung Memorial Hospital/ School of Medicine, Chang Gung University Sinus augmentation procedures are commonly used to increase bone height and to facilitate implant placement in the maxillary posterior areas. Mucosal pathologies in maxillary sinuses including mucosal thickening and retention cysts, associated or not associated with sinusitis, are occasionally found on the dental radiographs or computed tomographic (CT) films. These are traditionally considered as contraindications for sinus lifting procedures. This report, however, presents two cases in which sinus lifting surgery were performed in patients with mucosal pathologies of maxillary sinuses. The first case presented a 47-year-old female patient with an asymtomatic retention cyst in her left maxillary sinus. The second case was a 55-year-old male patient presented with bilateral thickened Schneiderian membrane and mild symptoms of sinusitis. In both cases, sinus lift and grafting procedures with lateral approach were successfully performed, without subsequent complications in the sinuses and grafted sites. (J Taiwan Periodontol 13:327-337, 2008) Key words: Dental implants, sinus augmentation, Schneiderian membrane, retention cyst Received: July 17, 2008 Revised: August 16, 2008 Accepted: October 22, 2008 Address reprint requests and correspondence to: Dr. Suefang Kung, Department of Dentistry, Chang Gung Memorial Hospital. 5 Fushin Street, Kweisan, Taoyuan, Taiwan 333. E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 337 338 J Taiwan Periodontol 13. No4. 2008 human gingival epithelial cells gingival fibroblast 12 4 ( 7 14 28 3 12 ) PLA-PGA 3 (2.31mm) 2.6mm 2.47mm e-PTFE @@ @@ @@ 3@ S5 .Y 1.01mm 1.05mm e-PTFE (0.74mm) PLA-PGA ( 13:339-349, 2008) 1,2,3 ; 1980 ; (0.5mm/ : 97 3 13 , : : 97 7 4 , : 97 11 ) 24 110 250 E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 339 4 1983 Nyman Gottlow 11,12,13,14 e-PTFE(expanded-polytetrafloroethene Postlethwahe 15 ) Nyman Saleman 16 Gottlow 5,6,7,8 ; 17 e- PTFE e- PTFE Nyman Locci DNA Gottlow e-PTFE ; Schegel18 8 65 Saleman 16 Johns 19 Millipore 9,10,11 6 10 PLA-PGA PLA-PGA ( e-PTFE ) 0.5-lmm 5 7 6 340 8 J Taiwan Periodontol 13. No4. 2008 ( PLA-PGA ) (24 e-PTFE wells) 0.3ml 103cell/ml 1.2ml 37 0.004 24 24 well 18 5% CO2 0.5%trypsin Flowcytometric analysis 2.34*104 RBC/ml PLA-PGA® glycolide trimethylene carbonate glycolide Student t test 3%Glutaraldehyde 90% 95% lactide 100% 70% 80% 100% and 100% 15 16 24 (S2400 Hitachi Japan) e-PTFE 12 expanded- polytetrafluoroethylene 12 (e-PTFE) 4 3 Ketalar(l0mg/kg) e-PTFE Pentobarbiturates 2%Lidocaine(1:50000 epinephrine) 12mm No.15 8mm well J Taiwan Periodontol 13. No4. 2008 341 1982 PGA 89.02cells 14.08 6.74 cells releasing line cell gingival epithelial 24 round bur 143.75 cells CEJ 400 cells e-PTFE 10mm 20,21 (P2) e-PTFE PLA-PGA 85.25 cells ( ) 24 1 1 (P1) (Ml) 2 2 (M2) human gingival fibroblast :1 gingival epithelial cells 2 PLA-PGA 1,21,22 human gingival fibroblast PLA-PGA PTFE 1 2 e- 4 gingival epithelial cells 3 PLA-PGA n = 3 e- PTFE 1 4% fibroblast human gingival gingival epithelial cells EDTA solution PLA-PGA e-PTFE 1 24 tometric Analysis 2 4 Flowcy24 well 3 human gingival fibroblast cell 624.67 31.52cells PLA- PLA-PGA Flowcytometric Analysis 1.01 mm e-PTFE 24 human gingival fibroblast gingival epithelial cell 624.67 31.52 143.75 46.37 PLA-PGA 1982 89.02 400 53.21 e-PTFE 14.08 6.74 * 85.25 10.11 * * : Significant difference , P < 0.05 342 PLA-PGA J Taiwan Periodontol 13. No4. 2008 24 human gingival fibroblast PLA-PGA 1.05 mm 24 PLA-PGA human gingival fibroblast PLA-PGA (x1.0k) (x1.0k) e-PTFE e-PTFE mm PLA-PGA 0.9 mm 3 0.74mm 2.6 mm 1 2.47mm 2 PLA-PGA e-PTFE 2.31mm 4 1 1.05 mm PLA-PGA PLA-PGA 2 0.9 e-PTFE Cementum Height (mm) Bone height (mm) 1.05 0 PLA-PGA 0.9 0 e-PTFE 0.9 0 2.6 1.01 PLA-PGA 2.47 1.05 e-PTFE 2.31 0.74 J Taiwan Periodontol 13. No4. 2008 343 4 2 3 5 PLA-PGA 23 1 2 24 4 2 4 3 1982 Nyman11 (e-PTFE) e-PTFE 1 2 4 2 4 3 1 2 Gottlow27 Becker28 Stahl Froum29 4 3 Karring Nyman23,24,25,26 344 Karring30 Iglhaut31 J Taiwan Periodontol 13. No4. 2008 14 6,20,21,22 21 21 CEJ 10mm 24 e-PTFE PLA-PGA ( ) e-PTFE PLA-PGA 15,16 12 12 Aukhil 0.004 human gingival fibroblast 5 3 Blumenthal 3 gingival epithelial cells 24 Jansen 1 2 1986 Schmitz 21 4 3 J Taiwan Periodontol 13. No4. 2008 345 PLAPGA 2.6mm 1.01 mm PLA-PGA e-PTFE glycolide trimethylenecarbonate glycolide lactide human gingival fibroblast gingival epithelial cells 24 PLA-PGA PLA-PGA 4 2 PLA-PGA 4 4 0.9 mm 3 2.47 mm e-PTFE 3 PLA-PGA 2.6mm 2.47mm e-PTFE (2.31mm); e-PTFE 1.01mm (0.74mm) 1.05mm e-PTFE PLA- PGA e-PTFE e-PTFE PLA-PGA e-PTFE 1 2 4 1. Kon S, Ruben MP, Bloon AA, et al. Regeneration of Periodontal Ligament Using Resorbable and Noresorabable Membrane 346 J Taiwan Periodontol 13. No4. 2008 2. 3. 4. 5. 6. 7. 8. 9. :Clinical, Histological, and Histometric Study in Dog. Int J Periodontics Restorative Dent, 11:59-71, 1991. Pitura S, Tal H, Soldinger M, et al. Collagen membranes prevent apical migration of epithelium during periodontal wound healing. J Periodontal Res, 22: 331-333, 1987. Blumental NM. The Use of Collagen Membranes to Guide Regeneration of New Connective Tissue Attachment on Dogs. J Periodontol, 59:830-836, 1988. Pitura S, Tal H, Soldinger M, et al. Partial Regeneration of Periodontal Tissues Using Collagen Barriers. J Periodontol, 59:380-386, 1988. Aukhil I, Simpson DM, Schaberg TV. An experimental study of new attachment procedure in beagle dogs. J Periodontal Res, 18: 643-654, 1983. Card SJ, Caffesse RG, Smith BA, et al. New Attachment Following the Use of a Resorbable Membrane in the Treatment of Periodontal in Dogs. Int J Periodontics Restorative Dent, 9:59-69, 1989. Caffesse RG, Nasjieti CE, Morrison EC, et al. Guided Tissue Regeneration: Comparison of Bioabsorbable and Non-Bioabsorbable Membranes. Histologic and Histometric Study in Dogs. J Periodontol, 65:583-591, 1994. Zeilin G, Gritli-Linde A, Linde A. Healing of mandibular defect with different biodegradable and non- biodegradable membranes: an experimental study in rats. Biomaterials, 16:601-609, 1995. Galgut P, Pitrola R,Waite I, et al. Histological J Taiwan Periodontol 13. No4. 2008 10. 11. 12. 13. 14. 15. 16. 17. evaluation of biodegradable and nondegradable membranes placed transcutaneously in rats. J Clin Periodotol, 18:581-586, 1991. Hyder PR, Dowell P, Singh G, et al. FreezeDried, Cross-linked Bovine Type 1 Collagen: Analysis of Properties. J Periodontol, 63; 3:182-186, 1992. Chaput C, Guirguis S, Leroux JC, et al. Characterization of thermosensitive chitosan gels for the sustained delivery of drugs. Int J Pharm, 203:89-98, 2000. Francis Suh JK, Howard WT. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials, 21:2589-2598, 2000. Pack YJ, Lee YM, Park SN, et al. Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration. Biomaterials, 21:153-159, 2000. Aiba S, Minoura N, Taguchi C, et al. Covalent immobilization of chitosan derivatives onto polymeric film surfaces with the use of photosensitive hetero-bifunctional crosslinking reagent. Biomaterials, 8:481-488, 1987. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblast to type I, 11, III collagens and collagen derived peptides. Proc Natl Acad Sci U S A, 75:817875, 1978. Saleman E. Biollogy, Biotechnology and Biocompatibility of collagen. Biocompatibilty of Tissue Analogs. 1 st ed. Boca Raton, FLCRC Press, pp.27, 1985. Locci P, Calvitti M, Belcastro S, et al. Phenotype expression og gingival fibroblast cultured on 347 18. 19. 20. 21. 22. 23. 24. 25. 348 membrane used in guided tissue regeneration. J Periodontol, 68 :857-863, 1997. Schegel AK, Mohler H, Busch F, et al. Preclinical and clinical studies of a collagen membrane (Bio-Gide). Biolmaterials, 18:535538, 1997. Johns LP, Merritt K, Agrarwal S, et al. Immunogenicity of a bovine collagen membrane in guided tissue regeneration. J Dent Res, 71:298, 1992. Fine A, Goldstein R H. The effect of transforming growth factor B on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem, 262: 3897-3902, 1987. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. J Clin Orthod, 205:229-308, 1986. Alberius P, Dahin C, Linde A. Role of osteopromotion in experimental bone grafting to the skull: A study in adult rats using a membrane technique. J Oral Maxillofac Surg, 50:829-834, 1992. Karring T, Nyman S, Lindhe J, et al. Healing following implantation of periodontitis affected roots into bone tissue. J Clin Periodotol, 7:96-105, 1980. Nyman S, Karring T , Lindhe J, Planten S, et al. Healing following implantation of periodontitis affected roots into gingival connective tissue. J Clin Periodotol, 7:394401, 1980. Karring T, Isidor F, Nyman S, Lindhe J, et al. New attachment formation on teeth with a 26. 27. 28. 29. 30. reduced but healthy periodontal ligament. J Clin Periodotol, 12:51-60, 1985. Nyman S, Gottlow J, Karring T, Lindhe J, et al. The regenerative potential of the periodontal ligament. An experimental study in the monkey. J Clin Periodotol, 9:257-265, 1982. Gottlow J, Nyman S, Karring T, Lindhe J, et al. New attachment formation as the result of controlled tissue periodontium by guided tissue regeneration. J Clin Periodotol, 11:494-503, 1984. Becker W, Becker B, Prichard R, et al. Root isolation for new attachment procedure: a surgical and suture method. Three case reports. J Periodontol, 58: 819-826, 1987. Stahl S, Forum S, Tarnow D, et al. Human histological responses to guided tissue regenerative techniques in intrabony lesions. Case reports on 9 sites. J Clin Periodotol, 17:191-198, 1990. T. Karring, S. Nyman, J. Lindhe, and M. Silirat, et al. Potentials for root resorption during periodontal wound healing. J Clin Periodotol, 11: 41 52 ,1984. 31. J. Iglhaut, I. Aukhil, D. M. Simpson, M. C. Johnston, and G. Koch, et al. Progenitor cell kinetics during guided tissue regeneration in experimental periodontal wounds. J Periodontal Res, 23:107 117, 1988. J Taiwan Periodontol 13. No4. 2008 Biological evaluation of periodontal regenerative barriers Ching-Kai Lin Jen-Chang Yang* Nai-Chia Teng* Yu-Hwa Pan Wen-Hsiang Hsu* Haw-Ming Huang* Wei-Jen Chang*+ Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan *College of Oral Medicine, Taipei Medical University, Taipei, Taiwan +Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan This study was to examine the historical changes of implanted three commercial GTR (Guided Tissue Regeneration) membranes for confirming the clinical feasibility in vitro and vivo. Among the resorbable GTR membranes, the collagen membrane is collagen base, and the PLA-PGA membrane is synthesized membrane, while the e-PTFE (Expanded polytetrafluoroethylene) is synthesized but nonresorbable. The membrane material was placed on the bottom of the hole of prepared culture well, then 2 culture wells were assembled to a study device by silicone sealing. And all of devices were placed in 24 wells culture plate. After 24 hours incubation, flowcytometric analysis was performed to measure the numbers of cells in the collection. Membranes were observed at SEM on both up-side and downside. Then Beagle dogs were used as animal model. Buccal mucoperiosteal flaps were reflected in the bilateral mandibular premolar and molar areas. Buccal alveolar bone was reduced on 1st and 2nd premolar and molar to a level 5 mm apical to the cemento-enemel junction (CEJ). Root surface was denuded of periodontal ligament and cementum, and notches were placed at the bone level of each root. The tested GTR barriers were implanted in critical bone defect areas. Flaps were coronally positioned and sutured. Two beagle dogs were sacrificed each time as the designed time period after surgery. Histological and histometirc evaluation at 7 days , 14 days, 28 days, 3 months were performed postoperatively to determine the healing response of each treatment modality. Both the cementum height and bone height were measured as the index of tissue occlusion effect. Like all resorbable GTR membrane, the collagen membrane and the PLA-PGA membrane were observed membrane resorption and cells infiltration in the fibril network after 24 hours incubation. But the collagen membrane and the PLA-PGA membrane enhanced the cementum regeneration of 2.6mm and 2.47mm averagely after 3months implantation. On the contrast, cementum height of 2.31 mm was observed in e-PTFE group. The collagen membrane and the PLA-PGA membrane seemed to be efficient in treatment of Guided Tissue Regeneration. (J Taiwan Periodontol 13:339-349, 2008) Key words: Guided Tissue Regeneration Periodontal membrane Received: March 13, 2008 Revised: July 4, 2008 Accepted: November 24, 2008 Address reprint requests and correspondence to: Dr. Wei Jen Chang, College of Oral Medicine, Taipei Medical University, 250 Wu Shin Street, Taipei 110, TAIWAN E-mail: [email protected] J Taiwan Periodontol 13. No4. 2008 349 350 J Taiwan Periodontol 13. No4. 2008 SP1 Clinical Applications of Emdogain® Dr. Hidetaka Kimura Enamel matrix proteins (Emdogain®) has multiple uses in reconstructive dentistry. Above all Emdogain®, which is thought to be regenerate periodontium destroyed by periodontitis, provide sufficient outcomes as a treatment technique to intrabony defect. This presentation will present some cases in which Emdogain was applied to periodontal regenerative therapy for the patients with severe periodontitis. The indication for Emdogain treatment will be also described. J Taiwan Periodontol 13. No4. 2008 351 SP2 Soft Tissue Management Using Root Coverage Dr. Tomoko Takeda Private practice since 1987, currently at Shimokitazawa Graduated from Tokyo Dental Collage in 1981 Graduated from New York University Perio-Implant CED in 2004 Certified dentist of Japanese Academy of Clinical Periodontology in 2004 Certified instructor of ISCD in 2007 Affiliated with AAP, JACP, JSP, Japanese Society of Oral Implantology and International Society of CAD /CAM Dentistry Gingival recession, root exposure, wedge-shaped defect and hyperesthesia often found in daily clinical are caused by attached gingival deficiency, highly-placed frenum, vestibular narrowing or cacoethic brushing. Annals of Periodontology” (AAP) was published in 1996 based on the concept that Periodontal Plastic Surgery has been developed in order to solve above-mentioned problems. This book defines that it is a periodontal surgical procedure to correct or prevent anatomical, embryologic, traumatic morphologic defect or the one caused by periodontal treatment.” Root coverage has been developed for the purpose of remedying root exposure having some problems by using periodontal plastic surgery. Especially in recent years, needs for dental esthetics is drastically increasing. Combined with needs for root coverage that can get patients satisfaction in a short period of time, various procedures have been considered and developed. During the early stages it was to prevent gingival recession rather than to cover the root. However, the ratio of coverage has increased to 90% since 1980 by using connective tissue implant. At the same time the purpose has changed from just covering the root to also obtaining new attachment. Even now there are various procedures newly reported in order to be more esthetic and regenerate, not only applying them to exposed root but also applying as one of the procedures before prosthesis including implant. This time, I would like to weigh various root coverage procedures and on that basis I would also like to weigh the pros and cons of soft tissue management for natural dentition as well as implant by using root coverage that I am now engaged on. And also, please let me hear your opinion. 352 J Taiwan Periodontol 13. No4. 2008 BR1 Preparation of Periodontal Board: Oral Test J Taiwan Periodontol 13. No4. 2008 353 SP3 Digital Photography and Intraoral Technique Dr. Paul P. Lin Dr. Ruey-Cheng Yu 354 J Taiwan Periodontol 13. No4. 2008 SP4 2008 Periodontal Treatment Needs and Developing Program in National Health Insurance in Taiwan 2008 Dr. Hongmin Lai Indiana Diplomate Dr. Yen-Ting Chen 18 99% 60% 2007 15-29% 48 (91004C) (needs) (demands) J Taiwan Periodontol 13. No4. 2008 355 CE1 Evidence-Based Medicine for Decision Makings in Periodontal Regeneration Dr. Suefang Kung / UCLA D.D.S. UCSF M.S. Evidence-Based Medicine (EBM) is the integration of best available evidences, clinical expertise and patient value in medical practice. It is also a set of procedures, pre-appraised resources and information tools to assist practitioners to apply evidence from research in the care of individual patients. The aims of this presentation are to introduce the basic knowledge in Evidence-based Medicine and to discuss the application of EBM strategies in our everyday practice in periodontal therapy. The first part is to introduce objectives and methods of EBM, along with the history of EBM and Cochrane collaboration. We will then illustrate a well-built clinical situation which is related to periodontal regeneration in periodontitis patient. Methods in literature search and evidence evaluation will be carried out to demonstrate the EBM strategies in making decisions in each step of treatment. The essential resources are also listed for future use by EBM practitioners. 356 J Taiwan Periodontol 13. No4. 2008 CE2 The Use of Collagen Membrane in GTR/GBR and Case Discussion Dr. Hsein-Kun Lu Professor, College of Oral Medicine, Taipei Medical University. Chair of Councilor Board, Association for Dental Science Research, Taiwan.Supervisor, Academy of Periodontology, Taiwan. e-PTFE (GLA GPA) 20 e-PTFE GLA GPA Collagen membrane needs allogenic graft as be the support in GTR/GBR technique. The unique character of tissue integration is the best part of the reason for using collagen membrane in GTR/GBR. It is simple, straight forward, predictable, and no need for suturing and secondary intention. J Taiwan Periodontol 13. No4. 2008 357 CE3 Application of Tissue Engineering and Gene Therapy for Regeneration Dr. Hen-Li Chen Oral Health Sciences Doctor of Philosophy Tissue engineering and gene therapy are emerging fields of biomedicine. Tissue engineering approach uses cells, scaffolds, and signals individually or in combination for regeneration. Gene therapies exert their therapeutic effects via modification of the genetic material of the cells. The use of protein-base signals suffers from short half life in vivo. Gene therapy can be used for sustained release of signals. With the extraordinary advances made in tissue engineering and gene therapy studies in recent years, their impact on dentistry has become more and more significant. The purpose of this presentation is to introduce the current status of tissue engineering and gene therapy studies in dentistry, especially for periodontics. The basic principles and approaches in tissue engineering and gene therapy will be reviewed. Our studies in craniofacial bone regeneration, periodontal regeneration and periimplant healing will be reported as examples. Though tissue engineering and gene therapy are mostly during animal study stage, their application in dental practice is expected to come within the next ten years. 358 J Taiwan Periodontol 13. No4. 2008 CE4 Stem Cells for Periodontal Therapy Dr. Kuo Yuan (ABP Diplomate J Taiwan Periodontol 13. No4. 2008 359 CE5 Contemporary Treatment Modalities for Periodontally Compromised Dentition Dr. Bor-Jian Chen TUFT 360 J Taiwan Periodontol 13. No4. 2008 CE6 Updates of Socket Preservation: Histological Evidences at Different Timing of Grafting Dr. Cheng-Sheng Ho (Fellowship) (site development) (osteoinductive) (osteoconductive) 6 9 1 2 2 6 J Taiwan Periodontol 13. No4. 2008 3 6 (bone grafting) 361 CE7 Non-Surgical Ridge Augmentation in Esthetic Zone: Indications and Limitations Dr. Yu-Min Cheng To achieve an optimal esthetic result in esthetic zone for implant rehabilitation has been quite challenging surgically and restoratively ever since. The treatment outcome is always limited esthetically if the previous dentition had been periodontally compromised. Even if several surgical procedures had been performed to correct the ridge deformity, the Pink esthetics is usually jeopardized. Enhancing the ridge topography at/before tooth extraction for future implant placement is necessary to achieve better esthetic outcome. The efficacy of tooth movement to correct periodontal defect has been well documented. By utilizing extrusive tooth movement, one can predictably enhance the volume of the soft tissue as well as the vertical height of alveolar bone without surgical intervention prior to implant surgery. Thus, a favorable outcome could be expected. This presentation will address 1. Strategy for single implant vs. multiple implants placement within esthetic zone. 2. Efficacy of extrusive tooth movement for implant site development and it's clinical applications. 3. Limitations of extrusive tooth movement for implant site development. 362 J Taiwan Periodontol 13. No4. 2008 CE8 Preservation of Implant / Failing Implant: Role of Soft / Hard Tissue Dr. Chuen-Chyi Tseng ITI Dr. Yi-Min Wu Dental implant plays an important role in oral rehabilitation. Like natural dentition, dental implant is surrounded by soft tissue and hard tissue in oral cavity. Solid foundation and rigid peri-implant seal is critical to dental implant for a long-term successful implant therapy. How to preserve and create implant site in a desirable situation of soft and hard tissue is an important issue in clinical practice. The aim of this presentation will focus on the role of soft / hard tissue on the preservation of implant and failing implant. The content of this report will include: 1. The role of soft / hard tissue in natural dentition and implant therapy; 2. To preserve and/or create implant site for implant therapy and implant esthetic; 3. To maintain the hard tissue for implant long-term purpose; 4. The role of keratinized mucosa in maintaining the peri-implant health. J Taiwan Periodontol 13. No4. 2008 363 CE9 Current Management of Peri-Implantitis Dr. Chi-Chou Huang ( ( ) , ) Dr. Lang 2003 364 CIST J Taiwan Periodontol 13. No4. 2008 RF1-1 The Role of Elastin in the Molecular Mechanism of Gingival Keratinization RF1-2 4 The Effect of Intraosseous Adenovirus-mediated BMP4 Gene Therapy on Dental Implant Stability RF1-3 PGE2 The Effect of Addition of Lipopolysaccharide (LPS) and Prostaglandin E2 (PGE2) on the Osteoblast-like Cells RF1-1 RF2-2 RF3-1 RF3-2 RF3-3 RF3-4 The Existence of Mesenchymal Progenitors in Primary Human Gingival Fibroblast-like Cell Populations The Expression of Toll-like Receptors in Human Gingival Epithelium The Relationship between General Bone Mineral Density and Oral Condition in Taiwanese Correlations of Coronary Artery Calcification and Periodontal Status Changes of Periodontal Status in Patients Undergoing Bone Marrow Transplantation Evaluation of anatomic structures of maxillary sinus for implant therapy RF3-5 Reconstruction and Localization of Mandibular Foramen Using CT Image in Taiwanese RF3-6 Resonance Frequency Analysis Measurements of ITI Implant Primary Stability at Implant Placement Surgery RF3-7 Correlation between gingival biotype and clinical esthetic features in Taiwanese young adults RF3-8 Factors Influencing the Presence or Recession of the Interproximal Dental Papilla J Taiwan Periodontol 13. No4. 2008 365 RF4-1 RF4-2 RF4-3 RF4-4 RF4-5 RF4-6 Diagnosis and Management of Cemental Tears of Mandibular Molars: Report of Two Cases Hereditary Gingival Fibromatosis: A Case Report Signs and Symptoms of Localized Periodontal Destruction over Upper Anterior Due to Iatrogenic Application of Elastic Band: Report of Three Cases Dental Treatment for Traumatically Injured Patient: A Case Report The Internal Tooth Resorption Following EDTA Surface Treatment and DFDBA/ Enamel Matrix Derivative Regenerative Surgery: A Case Report Treatment of a Combined Periodontic-Endodontic Lesion- A Case Report RF4-7 Bone Cavity Formation Following Extraction of a Mandibular Molar with Pulpal-Periodontal Combined Lesion: Report of Two Cases RF4-8 Guided Tissue Regeneration in the Treatment of Combined Large Periapical and Marginal Lesions: Report of Cases RF4-9 Autogenous Tooth Transplantation and Dental Implant for Oral Rehabilitation in Adult Patients: A Clinical Report RF4-10 RF4-11 Interdisciplinary Treatment of Periodontics, Orthodontics, Prosthodontics, and Implantology for a Patient with Generalized Severe Chronic Periodontitis: A Case Report Narrow Diameter Implant in Limited Space: A Case Report , RF4-12 366 Computed Tomography Aided Surgical and Prosthetic Treatment Planning for an Implant-supported Overdenture in Severely Atrophic Edentulous Mandible: A Case Report J Taiwan Periodontol 13. No4. 2008 RF4-13 RF4-14 : The Combination of Sinus Lift and Vertical Ridge Augmentation with Titanium Mesh: A Case Report Early Implant Placement in Esthetic Zone: A Case Report RF4-15 Combination of Soft Tissue Graft, Bone Substitute plus Regenerative Membrane, and Frenumnectomy to Enhance Anterior Implant Region Esthetics: Report of Two Cases RF4-16 Significant Increase of Serum Amylase Level after Dental Implantation: A Case Report RF4-17 RF4-18 RF4-19 RF4-20 Open Sinus Lifting in Atrophic Maxillae: A Case Report Ridge-splitting Technique with Simultaneous One-Stage Implant Placement for the Rehabilitation of Deficient Mandibular Edentulous Ridge: A Case Report Management of Peri-Implantitis Caused by Residual Cement: A Case Report : Hereditary Gingival Fibromatosis: Two Cases Report J Taiwan Periodontol 13. No4. 2008 367 RF1-1 The Role of Elastin in the Molecular Mechanism of Gingival Keratinization Tzu-Yuan Hung, Po-Chen Hsieh, Chia-Wen Chang, Tung-Yiu Wong, Shih-Chung Liao, Chi-Chou Huang, Kuo-Yuan National Cheng Kung University, Medical Collage, Institute of Oral Medicine, Tinan (elastin) K1 K4 K10 K13 transwell elastin K4 (KGF elastin (NOK) KGF K13 NKGF) organotypic culture NKGF elastin elastin neutrophil elastase NOK matrix metalloproteinase- 12 (macrophage elastase; MMP-12) elastin K4 K13 culture transwell NKGF elastin neutrophil elastase NOK MMP-12 K4 elastin elastin organotypic K13 elastin elastin elastase 368 elastin elastin J Taiwan Periodontol 13. No4. 2008 RF1-2 The Effect of Intraosseous Adenovirus-mediated BMP4 Gene Therapy on Dental Implant Stability 0 Nai-Chai Kuo, 0 Yu-Lin Lai, Hen-Li Chen Department of Periodontology, Taipei Veterans General Hospital, Taiwan Department of Dentistry, National Yang-Ming University, Taiwan 4 (bone morphogenetic protein-4, BMP4) BMP4 BMP4 1 (LacZ 0 4 BMP4 4 ) 8 8 BMP4 BMP4 BMP4 BMP4 4 J Taiwan Periodontol 13. No4. 2008 369 RF1-3 PGE2 The Effect of Addition of Lipopolysaccharide (LPS) and Prostaglandin E2 (PGE2) on the Osteoblast-like Cells 0 ( ) Yung-Ting Chi-Cheng Tsai Department of Periodontology, Faculty of Dentistry, Kaohsiung Medical University, Kaohsiung Hsu, 0 (PGE2) RANKL OPG OPG RANKL (PGE2) RANKL OPG MC3T3E1 cells Collagen g/ml ) 2.5 37 5 CO2 E. coli LPS 0.1 g/ml PCR(RT-PCR) 24hr 48hr flexible plate(Bioflex Culture Plateg/ml 72hr 1 g/ml mRNA RANKL OPG PGE2 RANKL OPG RANKL PGE2 2.5 g/ml RANKL 370 g/ml (0.1 OPG g/ml 1 g/ml) OPG/RANKL LPS OPG/RANKL OPG g/ml PGE2 2.5 PGE2 1 PGE2 1.25 PGE2 RANKL OPG PGE2 J Taiwan Periodontol 13. No4. 2008 RF2-1 The Existence of Mesenchymal Progenitors in Primary Human Gingival Fibroblastlike Cell Populations 1 1 1 1 1 2 2 Woei-Yean Khoo, 1 Chun-Li Chen,1 Chien-Mei Liu,1 Lein-Tuan Hou,1 Bu-Yuan Liu2 1Graduate Institute of Dental Sciences and Department of Periodontology 2Department of Oral Pathology, School of Dentistry, College of Medicine, National Taiwan University Background: Recently, the discovery of multipotent stem cell populations residing in periodontal ligament (PDL) and dental pulp provides exciting prospects of resource for periodontal or tooth regeneration. The expense of a tooth and difficulty in cultivating PDL and pulp cells, however, hinders the clinical application of PDL and pulp cells in tissue engineering for repairing dental tissues. In contrast, gingival cells could be easily harvested and expanded in vitro. Furthermore, gingiva has been reported to develop from an ectomesenchymal origin rather than a mesenchymal one, and ectomesenchymal stem cells are believed to be pluripotent during early development. Thus, the possible existence of ectomesenchymal stem cells in gingiva makes it of great importance to investigate the putative stem cell or progenitor cell populations in gingival fibroblasts. The purpose of this study is through flow cytometry and induced differentiation to prove the existence of putative stem cell populations in gingiva. Materials and Methods: Gingival fibroblast-like cells (GFs) from 5 subjects were isolated. The cell characterization and induced osteogenic and adipogenic differentiations of these 5 gingival fibroblastlike cells were analyzed and demonstrated by the flow cytometry, and molecular as well as immunohistochemical methods. Results: In this study, we observed all 5 primary human GFs expressed high level of mesenchymal stem cell markers, such as CD29, CD90, CD44 and CD105, whereas they showed distinctly low levels of dental-origined stem cell markers, such as Stro-1 and CD146. Although we did notice substantial difference in differentiation potentials between GFs form different individuals, all of them demonstrated the potentials to differentiate into at least one mesenchymal lineage, including osteoblasts or adipocytes. Conclusions: We speculate that primary human GFs comprise of not only fibroblasts but also mesenchymal progenitor cells (MPCs) of osteogenic and adipogenic lineages and possibly some mesenchymal stem cell (MSCs), to some extent. These observations provide clues in clinical applications of gingival cells in cell-based regeneration for dental tissue repair in future. J Taiwan Periodontol 13. No4. 2008 371 RF2-2 The Expression of Toll-like Receptors in Human Gingival Epithelium 1 1 1 1 2 1 2 YC Chen, 1 TY Hu,1 CM Liu,1 JH Jeng,1 CC Ku2 1Graduate Institute of Dental Sciences and Department of Periodontology, School of Dentistry 2Graduate Institute of Immunology, College of Medicine, National Taiwan University Background: Epithelial lining of the skin and digestive tract is the first physical barrier against the invasion of various overlying microflora. The epithelium also actively interacts with our immune system to maintain an optimal immune response. The emerging roles of Toll-like receptors (TLRs) in the development of chronic periodontitis prompt us to study the TLRs expression in gingival tissues and their activation in gingival epithelial cells. Materials and Methods: Human gingival tissues were collected from periodontally diseased and sound subjects (n=7 for each group). The expression of TLR4 and TLR9 were detected by immunohistochemical (IHC) staining. The expression of type I interferons and IL-8 in the Ca9-22 gingival epithelial cells upon activation of TLRs was measured with real-time PCR. Results: The expression of TLR4 and TLR9 was up-regulated in diseased gingiva by immunohistochemical analysis. Correspondingly, an increased frequency of nuclear translocation of nuclear factor- B (NFB), a hall-mark of TLRs signaling, was observed. Stimulation of Ca9-22 epithelial cells by ODN 2216, an activating ligand of TLR9, increased the transcription of Type I and Type II Interferon genes. Therefore, the activation of TLR9 in human gingival epithelium may cause increased secretion of Interferon- , - , and invading pathogens. , which may contribute the activation of host defense mechanism against Conclusions: Our data indicate that gingival epithelial cells express functional TLR4 and TLR9, which can be activated by ligands derived from periodontal pathogens to mediate cytokine gene expression. These events can be crucial in the pathogenesis of periodontal diseases. 372 J Taiwan Periodontol 13. No4. 2008 RF3-1 The Relationship between General Bone Mineral Density and Oral Condition in Taiwanese Pang-Ning Chuang, Ching Tong Division of Periodontics, Department of Dentistry, Taichung Veterans General Hospital. (BMD-bone mineral density) 39 al.1999 6 0 X 1 2 Klemetti et al.1994 45 Jowitt et (MCI- mandibular cortical index) J Taiwan Periodontol 13. No4. 2008 373 RF3-2 Correlations of Coronary Artery Calcification and Periodontal Status 01 3 1 1,2 1,2 1,2 2 2 3 Chen-Kang Wu, 0 1 Tsung-Hsien Lin,3 Kun-Yen Ho,1,2 Yea-Pyng Ho,1,2 Chi-Cheng Tsai,1,2 Kai-Fang Hu,2 1Faculty of Dentistry, College of Dental medicine 2Division of Periodontics, Department of Dentistry 3Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan cytokines MMP fibrinogen 30 16 PPD(probing pocket depth) CAL(clinical attachment level) BOP(bleeding on probing) Agaston score 4 mm 374 J Taiwan Periodontol 13. No4. 2008 RF3-3 Changes of Periodontal Status in Patients Undergoing Bone Marrow Transplantation Te-Chou Wang, Hwey-Chin Yeh Department of Periodontics, Devision of Dentistry, Lin-Kou Medical Center, Chang Gung Memorial Hospital Background: The immune system could be destroyed and replaced with donor in patients who received bone marrow transplantation (BMT). It might result in a compromised immunity of patients during and/or after BMT. Periodontal disease is known as an infection disease and subjects' response to bacterial plaque is mediated by immune system. Information on changes of susceptibility to periodontal disease in BMT patients was limited in documents. The purpose of this study was to evaluate changes of periodontal status in hematological patients who underwent BMT. Materials and Methods: Twenty hematological patients were referred for dental prophylaxis before BMT. Patients' age, gender, hematological disease and type of BMT were recorded. Radiographic, intraoral examinations and periodontal parameters were measured. Dental and periodontal treatments, if needed, were provided before BMT. All measurements were repeated at least 6 months after BMT. Results: The relationship between changes of clinical attachment levels and patient's hematological diseases was not statistically significant. Neither was the type of BMT, with or without chemotherapy, levels of radiotherapy before BMT, or an existence of graft-versus-host-disease. However, patients with a relapse of hematological disease showed significant loss of clinical attachment level. Conclusion: This study demonstrated that change of immunity during BMT did not affect periodontal status significantly, whereas aggressive form of periodontal attachment loss might occur in hematological patients with post-BMT relapse. J Taiwan Periodontol 13. No4. 2008 375 RF3-4 Evaluation of anatomic structures of maxillary sinus for implant therapy Chien-hsing Wang, Yi-chun Lin, Bor-Jian Chen, Yu-lin Lai Dental Department, Veterans General Hospital-Taipei School of Dentistry, National Yang-ming University (sinus septa) 2002 2008 38 40.8% 39.5% 100% 72.4% 7.9% 35.1% 20% 10% 6.30 376 19.7% 26.3% 17.9% 3.70 15.9% 3.14 35% 30% 5% 6.41 6.23 2.96 J Taiwan Periodontol 13. No4. 2008 RF3-5 Reconstruction and Localization of Mandibular Foramen Using CT Image in Taiwanese 01 1 1 Lian-Ping Mau Jun-Jung Chen, 2 2Dental 2 2 0 1, 1Dental 1 Chuen-Chyi Tseng,1 2 3 3 Iok-Chao Pang,1 Kuo-Ching Huang, 2 Miin-Jye Wen3 Department, Chi Mei Medical Center, Tainan Department, Chi Mei Hospital, Liouying Campus, Tainan 3Department of Statistics, National Cheng Kung University, Tainan Background: To perform dental treatments in the lower jaw, there are quite often need inferior alveolar nerve block. Therefore, inferior alveolar nerve block is an absolutely important skill for a dentist in daily practice. Mandibular foramen (MF) is the place where local anesthesia solution is deposited. In order to achieve adequate local anesthesia, MF becomes an important landmark structure. The aim of this study was to determine the relationship between dentition and MF in Taiwanese adult population. Materials and Methods: 65 mandibular dental CT images were selected from our data bank. There are 28 males and 37 females. The average age is 44.23 years old, range 20 to 72 years old. Dental CT images were performed using Implant Max® software. The Occlusal plane (OP) is defined as the horizontal plane between opposite mandibular posterior teeth parallel to the floor. The inferior alveolar nerve was reconstructed and the MF was located. Then the cross section over the lingula parallel to the OP was located, the anteroposterior and superoinferior relationship of the lingula was measured. Results: The results showed (1) Lingula is 12.93mm posteriorly to the internal anterior ramus (IAR), 18.93mm posteriorly to the external anterior ramus (EAR) and 17.47mm anteriorly to the posterior ramus (PR). (2) Lingula is 6.35mm above the occlusal plane (OP). (3) Inferior MF is 1.69mm below the OP. (4) The position of lingula between males and females and right and left side is not statistically significant. Conclusions: This study demonstrated that lingula is located just posterior to the middle of the ramus correspond to the EAR to PR and just above the occlusal plane. This identify the landmarks that would provide the most reliable and predictable indicators of the exact position of the MF to the clinician during the inferior alveolar nerve block procedure. (This study was supported by Chi Mei Medical Center, Grant no. CMFHR9644) J Taiwan Periodontol 13. No4. 2008 377 RF3-6 Resonance Frequency Analysis Measurements of ITI Implant Primary Stability at Implant Placement Surgery 01 2 1 1 2 1 2 Mei-Yin Lin, 0 1 Chun-Jung Chen,2 Lian-Ping Mau,1 Kuo-Ching Huang,2 Chuen-Chyi Tseng1 1Dental Department, Chi-Mei Medical Center, Tainan 2Dental Department, Chi Mei Medical Center, Liouying Campus, Tainan (primary stability) (osseointegration) (resonance frequency analysis) 67 115 ) ISQ (78.42) 28 39 45.6 ) ITI (ISQ (79.11) ( (bone quality) 77.78 (74.48) 10mm 78.19 4.1mm (78.42) (75.79) (Type II ISQ (77.98) 4.8mm 80.18) (78.13) (75.79) 12mm (Type III 77.41) ITI 378 J Taiwan Periodontol 13. No4. 2008 RF3-7 Correlation between gingival biotype and clinical esthetic features in Taiwanese young adults 01 1 2 2 2 2 Chun-Jung Chen, 0 1 Chia-Hu Chien,2 Iok-Chao Pang, 2 Chuen-Chyi Tseng2 1Dental Department, Chi Mei Hospital, Liouying Campus, Tainan 2Dental Department, Chi-Mei Medical Center, Tainan (dental implant) osseointegration) (success (anterior aesthetic) (gingival biotype) 39 22.9 21 ( 18 ) SPSS ( ) ( ) J Taiwan Periodontol 13. No4. 2008 379 RF3-8 Factors Influencing the Presence or Recession of the Interproximal Dental Papilla 01 2,4 1 3,4 2,4 2,4 2 3 4 Min-Chieh Chen, 0 1 Chiu-Po Chan,2,4 Yu-Fang Liao,3,4 Whei-Lin Pan,2,4 1Division of Dentistry, Chang-Gung Memorial Hospital, Keelung 2Department of Periodontics, Chang-Gung Memorial Hospital, Taipei 3Craniofacial Orthodontics, Chang-Gung Memorial Hospital, Taipei 4College Yuh-Ren Ju2,4 of Medicine, Chang-Gung University, TaoYun X 30 102 Tempbond˛ (mucogingival junction, MGJ) X X (presence) (Image J software) [1] the papilla) (contact point) [3] (bone crest) (keratinized gingiva) [1] [2] [4] (length of (interdental distance) (p<0.001) [2] (p<0.05) [3] 5 mm X 380 J Taiwan Periodontol 13. No4. 2008 RF4-1 Diagnosis and Management of Cemental Tears of Mandibular Molars: Report of Two Cases 1,3 2 1 1 2 3 3 Hsueh-Jen Lin, 1,3 Chiu-Po Chan,2 Chen-Tsai Wu,1 Jiiang-Huei Jeng3 1Dental Department, Show Chwan Memorial Hospital, Changhua 2Chang Gung University, Department of Periodontics, Chang Gung Memorial Hospital, Taipei 3Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei (cemental tear) 57 (biopsy) 38 10mm C- J Taiwan Periodontol 13. No4. 2008 1/3 381 RF4-2 Hereditary Gingival Fibromatosis: A Case Report 0 Pei-Chi Kao, 0 Cheing-Meei Liu, Yuh-Yuan Shiau, Thai-Yen Ling Department of Periodontology, National Taiwan University Hospital Institute of Pharmacology, College of Medicine, National Taiwan University Background: Hereditary gingival fibromatosis (HGF) is a genetic disorder characterized by a progressive enlargement of the attached gingiva and various degrees of soft tissue dimensional change. It usually develops as an isolated oral manifestation but can be one feature of an associated genetic syndrome. This article was a case report to show the hygienic and esthetic improvement after adequate periodontal treatment in the patient with HGF, and to present the histopathologic characteristics of fibromatotic tissue. The gene expression profiles of the resectional tissue were also analyzed in order to explore the putative genes regulation in the pathogenesis. Materials and Methods: A case of a 36-year-old male was reported, who presented a generalized severe gingival overgrowth, involving the maxillary and mandibular arches and covering almost all teeth. The x-ray photography indicated the alveolar bone of the patient was normal. Meanwhile, seven of the patient's family members also presented HGF with different degree. Surgical treatment consisted of quadrant-by-quadrant conventional gingivectomy procedures. And histopathologic analysis by H&E stain was carried out to observe the morphologic characteristics in the HGF sample. To characterize the genes expression profiles of the sample, microarray analysis was performed to compare with the normal gingival tissues. Results: The postoperative courses were uneventful and the patient's appearance improved considerably. Post-surgical follow-up after 11months demonstrated no recurrence. The overgrowth lesions contained well-structured epithelium with elongated and thin papillae inserted in expanded fibrous connective tissue The gene expression profiles derived form microarray analysis showed that there were several genes with significant high or down regulated comparing to control group, such as homo sapiens arylacetamide deacetylase-like 2 (AADACL2) and homo sapiens carbohydrate (Nacetylgalactosamine 4-0) sulfotransferase 9 (CHST9). Conclusions: Hereditary gingival fibromatosis is a rare disorder characterized by the proliferative epithelial and fibrous overgrowth of the gingival tissue in Chinese population. Resectional surgery of the excess tissue is the available treatment. For further studies, to interpret the pathogenesis of HGF by ingenuity pathway analysis according microarray results will be our subsequent work. 382 J Taiwan Periodontol 13. No4. 2008 RF4-3 Signs and Symptoms of Localized Periodontal Destruction over Upper Anterior Due to Iatrogenic Application of Elastic Band: Report of Three Cases Yan-Ting Lin, Hsiang-Hsi Hong Department of Periodontics, Devision of Dentistry, Lin-Kou Medical Center, Chang Gung Memorial Hospital x x 3 - 8 #11#21 III x 4-9mm #11#21 11 #21#22 4-8mm III x #21#22 8 #11#21 2-6mm III x #21#22 x 1. 2. 3. divergence) J Taiwan Periodontol 13. No4. 2008 (extrusion) (granulation island) 5. 6. (crown 4. (root convergence) 7. x 383 RF4-4 Dental Treatment for a Traumatically Injured Patient: A Case Report 0 Yu-shan Huang, 0 Bor-jain Chen, Yi-chun Lin, Yi-chen Hiseh, Department of Dentistry, Taipei Veterans General Hospital, Taiwan School of Dentistry, National Yang-Ming University Yu-lin Lai (tunnel technique) 384 J Taiwan Periodontol 13. No4. 2008 RF4-5 The Internal Tooth Resorption Following EDTA Surface Treatment and DFDBA/ Enamel Matrix Derivative Regenerative Surgery: A Case Report 0 Chih-Hao Huang 0 Department of dentistry, Buddhist Tzu-Chi general hospital, Hualien, Taiwan Background: The internal tooth resorption following periodontal regenerative therapy is uncommon. This case report provides information regarding adverse reactions following the usage of EDTA surface treatment and DFDBA/ Enamel matrix derivative(EMD) regenerative surgery. Materials and Methods: A 45-year-old man in good general health presented with a uncomfortable feeling on right mandibular molars. Further periodontal examination revealed probing depths of the right mandibular first molar ranged from 3 to 9 mm, and lingual furcation grade I involvement was noted. Radiographs revealed that the tooth had mesial and distal angular bony destruction, furcation radiolucency and heavy calculus deposition. The patient's periodontal diagnosis was generalized moderate to severe chronic periodontitis. Treatment of the tooth consisted of cause-related therapy, scaling/ root planing, EDTA surface treatment, DFDBA bone grafting and EMD regeneration. Results: Six months after surgical treatment, a correction of intrabony defect was observed. Clinical probing depths reduced to no more than 3mm with only slight recession and no furcation involvement. Bone fill was radiographically noted. However, severe hypersensitive sensation following surgery sustained more than 2 years without obvious abnormal electrical pulp test response. Although hypersensitivity gradually faded off after three years, an internal tooth resorption was noticed 4 years after regenerative surgery. Conclusion: It appears that some cases of mandibular molar intrabony defects treated by EDTA surface treatment, and DFDBA/ EMD regenerative therapy that are complicated by severe hypersensitive consequence, an internal tooth resorption may happen later. J Taiwan Periodontol 13. No4. 2008 385 RF4-6 Treatment of a Combined Periodontic-Endodontic Lesion- A Case Report 10 Chun-Ya Chan, 10 Fu-Ying Lee Department of Periodontology, Division of Dentistry, Chang Gung Memorial Hospital, Lin Kou Medical Center, Taoyan Background: Symptoms and signs of a combined periodontic-endodontic lesion usually mimic the characteristics of both periodontal and endodontic diseases. It is even confused and difficult in diagnosis when a periapical lesion extends coronally to meet a periodontal pocket or when a periodontal pocket is associated with anatomic deformities. Case Report: A 53-year-old female was diagnosed with generalized moderate to severe periodontitis. Non-surgically periodontal therapy has been completed, whereas a 12-mm pocket constantly existed at the mesial surface of her right mandibular first premolar, tooth #44. Severe bone destruction adjacent to the tooth was evident on radiograph. The pulp was tested non-vital. It was therefore diagnosed as a combined periodontic-endodontic lesion. Root canal treatment was firstly performed and followed by periodontally surgical debridement. The bony defect was grafted with demineralized freeze dried bone allograft (DFDBA) alone. Wound healing was uneventfully. Supportive periodontal therapy was maintained every 6 months. After 8 years of follow-up, clinical periodontal parameters of tooth #44 was well maintained. Although recession of marginal tissue was noted, bone fill surrounding the tooth was suggested on radiograph. Conclusion: Comprehensive examinations with assistance of radiograph and pulp vitality test help periodontists to accurately identify a combined periodontic-endodontic lesion, which could be maintained in health when treatments in sequence were provided. 386 J Taiwan Periodontol 13. No4. 2008 RF4-7 Bone Cavity Formation Following Extraction of a Mandibular Molar with PulpalPeriodontal Combined Lesion: Report of Two Cases Hsiu-Wan Meng, Pein-Chi Wei, Yu-Ren Ju Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital (Hematoma) (Degeneration) (Organization) 33 #47 #46 MOD X #46 #47 #47 #46 X #47 D)x3.8mm(B-L) (undermined) #46 3.8mm ( 50 6mm(M15mm ) #36 #36 5mm X 2.2mm #46 #36,37 10mm (Lamina dura) (Pyogenic granuloma) J Taiwan Periodontol 13. No4. 2008 387 RF4-8 Guided Tissue Regeneration in the Treatment of Combined Large Periapical and Marginal Lesions: Report of Cases 1 2,3,4,5 1 2 3 4 5 Hsiang-hsun Huang, 1 Tony Shing-zeng Dung2,3,4,5 1Tsong Kwun Dental Clinic 2Department 3Tzuchi of Dentistry, Buddhist Tzuchi General Hospital, Taipei University 4National Yang-Ming University 5Taipei Medical University Background: The maintenance of single teeth may often be of crucial importance for the prognosis of the total dentition. The successful treatment of large combined perioodontal and periradicular defects by combined endodontic and periodontal regenerative therapy is described. Case Reports: This study reports the treatment of three cases with combined large periapical and marginal lesions. The defect was thoroughly debrided and the exposed root surface was planed with curettes, ultrasonics and rotory instruments. After endodontic treatment, guided tissue regeneration is utilized to regenerate lost periodontium. The defects were filled with alloplasts (Interpore 200, Bio-Oss, or MBCP) and resorbable membranes (Resolute XT, PeriAid, or EpiGuide). The influence of the individual components used in treatment is discussed. The advantage and disadvantage of the treatment modality is analyzed. Results & Conclusion: Patients were followed for 1-10 years. The clinical and radiographic results demonstrated excellent pocket depth reduction and bone fill. All treatments were considered successful. Long-term evaluation of the treatment outcome deserves further study. 388 J Taiwan Periodontol 13. No4. 2008 RF4-9 Autogenous Tooth Transplantation and Dental Implant for Oral Rehabilitation in Adult Patients: A Clinical Report 0 1,2,3 4 1 5 6 2 3 4 5 6 Tony Shing-zeng Dung, 0 1,2,3 1Department 3Taipei 5Dr. Jeng-feng Huang,4 of Dentistry, Tzuchi Hospital, Taipei Medical University, Taipei 4Boston Lin and partners Dental Clinic, Taipei Kim-Choy Low,5 2National John Jing-Jong Lin6 Yang-Ming University, Taipei Dental Clinic, Taipei 6Lin Jing-Jong Orthodontic Center, Taipei Background: Implant-supported fixed dentures are a predictable treatment modality for edentulous patients. Autotransplantation is an alternative treatment for replacing lost teeth when suitable donor teeth are available. Case Report: This clinical report presents two cases of successful autogenous tooth transplantation and dental implants for oral rehabilitation in patients under adult orthodontic treatment. A comparison of the two treatment modalities as well as success rates will be also discussed. One third molar and one premolar with complete root development were autogenously transplanted from their original sockets into new recipient sites in the mandible. In both cases, teeth were transplanted immediately after tooth extractions. To provide better adaptation of the donor teeth, the recipient alveolar sites were remodeled using surgical burs. Root canal treatment commenced before transplantation and the canals were medicated with a calcium hydroxide paste. Following successful transplantation, root canals were sealed and provisional restorations were made. Both patients were successfully treated with autogenous tooth transplantation and dental implant simultaneously. Conclusion: Autogenous transplantation of teeth with complete root formation may be considered as a viable treatment option to conventional prosthetic and implant rehabilitation for both therapeutic and economic reasons. Careful surgical and endodontic procedure, together with careful case selection may lead to satisfactory aesthetic and functional outcomes. J Taiwan Periodontol 13. No4. 2008 389 RF4-10 Interdisciplinary Treatment of Periodontics, Orthodontics, Prosthodontics, and Implantology for a Patient with Generalized Severe Chronic Periodontitis: A Case Report 01 1 1,4 2,4 3 1 2 1,4 1,4 1,4 3 4 Yu-Hsiang Chou,t1 Ya-Ping Ho,1,4 Jen-Chyan Wang,2,4 Szu-Ting Chou,3 Kai-Fang Hu1 Kun-Yen Ho,1,4 Yi-Min Wu,1,4 Chi-Cheng Tsai1,4 1Division of Periodontics 2Division of Prosthodontics 3Division of Orthodontics, Kaohsiung Medical University Hospital 4Faculty of Dentistry, College of Dental Medicine, Kaohsiung Medical University Background: Advanced periodontal disease is primarily characterized as severe attachment loss and reduction of alveolar bony support. Pathological tooth migration, labial inclination, spacing, and loss of arch integrity are in consequence. The sequelae often cause esthetic and functional problems to the patient. It is impossible to manage the complicated dental condition with periodontal therapy alone. Interdisciplinary approach is necessary. In this case report, we describe an interdisciplinary treatment, including periodontics, orthodontics, prosthodontics and implantology for a patient suffered from generalized severe chronic periodontitis. Case Report: A 50-years-old male patient complained his chewing function was insufficient for a long time. After oral and radiographic examinations, generalized severe chronic periodontitis was diagnosed. More than 50% attachment loss of almost all his teeth was noted. In addition, he also manifested symptoms and signs of posterior bite collapse described previously. Professional phase I periodontal treatment was performed at first. After re-evaluation of periodontal condition, we provided open flap debridement and thorough root planing before orthodontic treatment. Active orthodontic treatment for realignment of the malpositioned teeth and for reconstruction of stable occlusion was finished in 23 months. He rejected to extract some poorly prognostic teeth because he had very strong motivation to preserve his natural teeth and had very good oral hygiene care ability. Therefore, his upper dentition was restored with a telescopic denture. The edentulous areas of lower arch were reconstructed with implant-supported crowns via guided bone regeneration. Definite prosthesis was fabricated after upper immediate denture delivery eight months later. The treatment outcomes, including the periodontal condition, occlusion, and implant prosthesis were stable via clinical and radiographic evaluations. His chewing function, esthetics and phonetics were improved significantly. The patient was satisfied with the results of the combined treatment modality. Conclusion: In the periodontally compromised patient, such as this case, a close interdisciplinary treatment modality is crucial for successful outcomes. Advanced periodontal-orthodontic-prosthodontic-implant treatment may result not only in the rehabilitation of function to the periodontally deteriorated dentition but also a significant enhancement in occlusion, esthetics, and periodontal maintenance. 390 J Taiwan Periodontol 13. No4. 2008 RF4-11 Narrow Diameter Implant in Limited Space: A Case Report 1 1,2 1 1 2 Chia-Yun Tsai, 1Department 2Faculty 1 1 Yi-Min Wu,1,2 Ching-Fang Tsai,1 Yu-Chuan Tseng1 of Dentistry, Kaohsiung Medical University Hospital of Dentistry, Kaohsiung Medical University Background: Four positional parameters contribute to the success of the implant restoration, including buccolingual, mesiodistal, apicocoronal positions relative to the implant platform and angulation of the implant. This report presents a case of improper space distribution, after orthodontic treatment, a narrow diameter implant was placed in lower anterior limited space. Case Presentation: A 26 years old female patient presented with pus discharge from lower right area. Radiographic and clinical evaluation demonstrated a 42x43x bridge and root resorption of 42. After evaluation, 42 was extracted. Orthodontic treatment was performed to align teeth and a proper space between 41 and 43 was created. A 3i micromini-implant 3.25 mm x 13 mm was chosen to implant at 42 edentulous area due to the tooth size of 42 should be small. Autogeneous bone graft was taken from torus mandibularis and placed at buccal crestal area. Then a healing abutment was setting onto the implant. After the eight months healing phase, a final implant impression was made and a all ceramic crown was delivery. Conclusion: Our case demonstrated that a site have limited tooth diameter, a narrow diameter implant can be satisfied with function, aesthetic and phonetic and integrated successfully. J Taiwan Periodontol 13. No4. 2008 391 RF4-12 Computed Tomography Aided Surgical and Prosthetic Treatment Planning for an Implantsupported Overdenture in Severely Atrophic Edentulous Mandible: A Case Report 01 1 2 1 1 1 Ting-An Chou, 0 1 1Department Whei-Lin Pan,1 of Periodontology, Pi-Lun Chen,2 2Department Yuh-Ren Ju,1 Chiu-Po Chan1 of Prosthodontics Background: When planning for implant placement in clinically challenging cases, detailed evaluation of potential osteotomy sites by advanced diagnostic methods is necessary. Computed tomography reveals to be the most precise radiographic technique till now. Case Report: The 45-year old healthy male has a very atrophic edentulous mandible and limited interarch space. By the dental CT, we could measure the bone height for implant placement precisely. No adequate bony height was left when we put ideal implant position as prosthetic requirement. We planned to implant three fixtures more buccally to gain longer fixture-support by CT guided-surgical stent. Finally three implants were placed on #45, #47, #37 edentulous areas. Conclusion: In this report, we will describe how to use dental CT to analyze the optimal position and support of implants for the severely compromised bone characteristic. 392 J Taiwan Periodontol 13. No4. 2008 RF4-13 The Combination of Sinus Lift and Vertical Ridge Augmentation with Titanium Mesh: A Case Report Shih- Chung Liao, Kuo Yuan, Ju-Chun Fan Chiang Department of Stomatolgy, National Cheng Kung University Hospital. Background: After extraction of teeth due to periodontitis in the maxillary upper posterior area, the site of extraction often demonstrated a vertical bone defect and a close distance to maxillary sinus. Meanwhile, we have to reconstruct the site with combination of sinus lift and vertical ridge augmentation for placement of implant. Materials and Methods: The right upper first molar was extracted due to severe periodontitis in a 40 y/o male. The combination of sinus lift and vertical ridge augmentation was performed over the site 2 months later. After 6 months uneventful healing period, the second stage surgery was performed .The prosthesis was delivered and functioned. Results: The height and width of the site was increased significantly and the sinus demonstrated bone filled around the implant on the radiograph. The function of the implant is well. Conclusions: We have to reconstruct the bone in the cases with severe bone destruction. In order to get esthetic and function, the regeneration of bone was not only performed in the sinus but in the vertical direction. J Taiwan Periodontol 13. No4. 2008 393 RF4-14 Early Implant Placement in Esthetic Zone: A Case Report 0 2 2 2 Yee-Ting Siaw, 0 Chuen-Chyi Tseng, Chih-Wen Cheng,2 Iok-Chao Pang2 Periodontal Division, Dental Department, Chi Mei Medical Center, Tainan 2Prosthodontic Division, Dental Department, Chi Mei Medical Center, Tainan (immediate implantation) (early implant placement) (primary stability) 28 (GBR) (second stage surgery) (early implant placement) 394 J Taiwan Periodontol 13. No4. 2008 RF4-15 Combination of Soft Tissue Graft, Bone Substitute plus Regenerative Membrane, and Frenumnectomy to Enhance Anterior Implant Region Esthetics: Report of Two Cases 0 Wen-Chieh Lo 0 Private practice Background: Implant esthetics in anterior area is the most challenged work for dentists. Tooth lost for a long time, severe periodontitis and trauma usually cause severe bone resorption and soft tissue deficiency. Guided bone regeneration (GBR) is often necessary in deficient ridge or for immediate implant when patient asks for shorter period of treatment. Sometimes staged soft and/or hard tissue graft is needed in second stage or even after prosthesis delivery. Materials and Methods: Case 1: Patient asked immediate implantation at the maxillary left central incisor with severe periodontitis and extensive bony defect. Cover screw exposure and high frenum attachment were noted after implant inserted and combined with GBR. Frenectomy, bone graft with regenerative membrane and connective tissue (CT) graft were performed to increase height and thickness of soft tissue. Frenectomy can increase the stability of the graft area. Case 2: Ridge resorption, lack of keratinized tissue and high frenum attachment were noted at patient's maxillary anterior area due to tooth lost for a long time. Neck margin of implant at upper central incisors was exposed after prosthesis treatment. Patient also complained of insufficient lip contour. Frenectomy, CT graft and bone graft were performed. Result: 1, Esthetics in the maxillary anterior areas of these two cases was improved. 2, Patient was satisfied with the fullness of facial contour in the second case. 3, Keratinized soft tissue was increased and maintained stable at one year follow-up. Conclusion: Many factors influence implant esthetics. Problems of soft tissue at the implant site must be assessed. Techniques for soft tissue management in the esthetic zone enhance mucosal thickness around implants and give a more predictable result. J Taiwan Periodontol 13. No4. 2008 395 RF4-16 Significant Increase of Serum Amylase Level after Dental Implantation: A Case Report Yen-Li Wang, Yuh-Ren Ju, Chiu-Po Chan, Whei-Lin Pan Department of Periodontics, Chang Gung Memorial Hospital, Taipei. Background: People with pancreatic disease are often found to have elevated serum levels of exocrine pancreatic enzymes, such as amylase and lipase. Determination of elevated enzyme levels has been one of the most convenient diagnostic tests and is particularly useful in patients with an acute phase of pancreatic disease. High blood amylase and lipase levels may occur in patients with clinically mild or severe acute pancreatitis, and a rapid fall in these levels may mean either resolution or extension of the disease. Case Report: In our case, the patient received dental treatment including tooth extraction and dental implant. Either time it was found that the serum amylase level was elevated after dental treatment, and dropped down thereafter. The only clue of amylase elevation is dental treatment, which was supposed to cause some form of trauma to the patient. After evaluating the pancreatic serum levels and physical examination by physician, it was thought unlikely to progress into acute pancreatitis. Conclusion: The relation between dental treatment and increased serum amylase level is not available in papers so far. The case gives us some insights. First, the time span between dental treatment and blood test in patients with elevated serum amylase level should be long enough. Second, the dental treatment may cause elevated serum amylase level to rise, which should be noticed, but may not be worried. 396 J Taiwan Periodontol 13. No4. 2008 RF4-17 Open Sinus Lifting in Atrophic Maxillae: A Case Report ,0 1 1 1 2 1 1 2 Cheng-Pang Lan, 0 1 Whei-Lin Pan,1 Pi-Lun Chen,2 Yuh-Ren Ju,1 Chiu-Po Chan1 1Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan 2Department of Prosthodontics, Chang Gung Memorial Hospital, Taipei, Taiwan Background: Reconstruction of the atrophic edentulous posterior maxilla poses a signi_cant challenge to the clinician. Hard tissue augmentation therapy prior to implant placement and prosthetic reconstruction is often necessary due to pneumatization of the maxillary sinus. Comprehensive management of this area requires meticulous diagnosis and treatment planning prior to initiation of augmentation, implant, or prosthetic therapies. Case Report: A 61-year-old male patient presented the upper left edentulous maxillae with pneumatized sinus. The computed tomography revealed only 2-3mm crestal bone height for edentulous area. This case report represents placement of two implants in the severely atrophic maxillae by open sinus lifting procedure. Open sinus lifting procedure was performed and augmented with bone graft and membrane. After 10 months uneventful healing, tomogram showed crestal bone height increased to 12mm and two implants were installed. Conclusion: In this case report, open sinus elevation is used for future implant site development in atrophic maxillary edentulous ridge. J Taiwan Periodontol 13. No4. 2008 397 RF4-18 Ridge-splitting Technique with Simultaneous One-Stage Implant Placement for the Rehabilitation of Deficient Mandibular Edentulous Ridge: A Case Report 1 1 2 1 2 E-Ling Lin, 1 Chun-Jen Cheng,2 Hwey-Chin Yeh1 1Department of Periodontics 2Department of General Dentistry, Division of Dentistry, Chung Gung Memorial Hospital Lin Ko Medical Center, Taoyun, Taiwan Background: Although onlay-inlay grafts, sandwich osteotomies, guided bone regeneration, piezoelectricity, and alveolar distraction have been indicated for augmentation in the mandibular region, each of these techniques involves risks, complications and usually require staged approach and involve multiple surgical sites. It is difficult to demonstrate that a particular surgical procedure offers better outcome as compared to another. A staged ridge-splitting technique enables immediate implant placement and lateral ridge augmentation in thin crests and may prevent neurosensorial deficiencies. Case Report: A 57-year-old female sought for full mouth rehabilitation and implant therapy. Insufficient bone width was noted at right mandibular edentulous ridge via CT evaluation. Corticotomy was first performed under anesthesia and flap elevation. One month later, ridge-splitting technique using synthetic particulate bone graft and a resorbable membrane was performed simultaneously with three one-stage implant placement. These implants were restored with fixed partial denture after 6 months. Peri-implant conditions were assessed clinically and radiographically. Implant-supported fixed prosthesis has stayed in health and function for 6 months. Conclusion: Ridge-splitting technique with simultaneous one-stage implant placement is a valid reconstructive procedure for deficient mandibular ridges. It helps in reducing surgical trauma and condensing treatment time. Long-term, multi-center studies are required to provide further insight into this technique. 398 J Taiwan Periodontol 13. No4. 2008 RF4-19 Management of Peri-Implantitis Caused by Residual Cement: A Case Report 1 2 1 1 2 Lin Cheng-Jyun, 1 Huang Kuo-Ching,2 Tseng Chuen-Chyi1 1Department of Periodontics, ChiMei medical center, Tainan 2Department of Periodontics, ChiMei medical center, Liouying Campus, Tainan Branemark ® 34 implant 24 J Taiwan Periodontol 13. No4. 2008 3 X 399 RF4-20 Hereditary Gingival Fibromatosis: Two Cases Report 0 Ying-Huei Yeh, 0 Chih-Hao Huang Department of dentistry, Buddhist Tzu-Chi general hospital, Hualien, Taiwan 1/175,000 25 12 25 12 400 J Taiwan Periodontol 13. No4. 2008 SUBJECTS INDEX Autogenous Tooth Transplantation : Literature Review and A Case Report 75 A Review and Treatment in Drug Induced Gingival Overgrowth 217 Bone block grafts from mandibular symphysis for ridge augmentation -A case report 33 Biological Evaluation of Periodontal Regenerative Barriers 339 Bisphosphonate -related osteonecrosis (BRON) of the jaw : Case report 231 Central Papilla Area in Young Adults with or without Central Papilla Recession 99 Combined therapy of surgical crown lengthening, apicoectomy, and ridge augmentation in the treatment of maxillary anterior teeth: A case report 23 External apical root resorption during orthodontic treatment 41 Expression of heat shock proteins in periodontal tissue 127 Effect of bioactive glass: literature review 139 Factors influencing the presence or recession of the interproximal dental papilla 269 Geometrical Characteristics on Anterior Loop of Inferior Alveolar Nerve in Taiwanese 11 Gingival Bleeding Disorders and Idiopathic Thrombocytopenic Purpura:Case Report 291 Incomplete osteointegration of one-staged non-submerged implant placement: Case report 209 Influences of Biphasic Calcium Phosphate Scaffold Porosity on Bone Tissue-Engineering : Literature review 247 Implant restoration in severely resorbed and HA-augmented ridge -A case report 57 J Taiwan Periodontol 13. No4. 2008 401 Interdisciplinary Therapy of Orthodontics and Implantology for Trauma Patient: A Case Report 65 Management and prevention of dental implant displaced into maxillary sinus: a case report and literature review 51 Mandibular Incisive Canal on Dental CT Image in Taiwanese 239 Multiple implants treatment in an elderly patient - A case report 301 New trend for dental care 255 Periodontal full treatment case report 109 Periodontal full treatment case report and literature review 189 Recording of Gingival Overgrowth in Rats: Comparison of Two Measurements 1 Sinus Augmentation into Sites with Mucosal Pathologies of Maxillary Sinus 327 The application of crown lengthening procedure and elevation of occlusal plane to create the interarch space: A case report 315 The consideration of orthodontic treatment in periodontal therapy -literature review 87 The relationship of vitamins vs. oral and periodontal tissue diseases -Literature review 147 The role of chemokines in periodontal disease 157 The relationship of Hyperbaric oxygen v.s. Periodontitis -Literature review 169 The influence of laser on dental implant in the treatment of peri-implantitis:literature review 177 Treatment of distal circumferential bony defects around the mandibular secondary molars with demineralized bovine xenograft - A case report 279 402 J Taiwan Periodontol 13. No4. 2008 KEY WORDS INDEX A alveolar bone crest 13:269 anterior loop 13:11 antiepileptic drugs 13:217 apicoectomy 13:23 autogenous tooth transplantation 13:75 autotransplantation 13:75 B bioactive glass 13:139 biphasic calcium phosphate 13:247 bisphosphonate 13:231 bone block graft 13:33 C calcium channel blockers 13:217 central papilla 13:99 circumferential defect 13:279 chemokine 13:157 chronic periodontitis 13:109,189 complications 13:51 contact area 13:269 crown lengthening procedure 13:315 cyclosporine 13:1 cytokines 13:169 D demineralized bovine xenograft 13:279 dental CT 13:11,239 dental implant 13:33,51 dental implants 13:327 differential diagnosis 13:255 donor tooth 13:75 J Taiwan Periodontol 13. No4. 2008 E elderly patients 13:301 embrasure 13:99 embrasure morphology 13:99 enamel destruction 13:255 Er:YAG laser 13:177 etiology of incomplete osseointegration 13:209 erosion 13:255 external apical root resorption 13:41 G gingival bleeding disorders 13:291 gingival overgrowth 13:1,217 guided bone regeneration 13:57,65 guide tissue 13:109 guided tissue regeneration 13:189,339 H heat shock proteins 13:127 HO-1 13:169 hydroxyapatite 13:57 hyperbaric oxygen 13:169 I idiopathic thrombocytopenic purpura 13:291 immunosuppressants 13:217 implant 13:177,209,301 inflammation 13:127 interproximal dental papilla 13:269 implant-supported prostheses 13:301 inferior alveolar nerve 13:11 insufficient interarch space 13:315 interdental distance 13:269 403 intrabony defect 13:109 K keratinized gingiva 13:1,269 J jaw bone 13:231 M macroporosity 13:247 mandibular incisive nerve 13:239 mandibular secondary molar 13:279 mandibular symphysis 13:33 maxillary sinusitis 13:51 mental foramen 13:11 microporosity 13:247 N NO 13:169 O one-stage non-submerged implant 13:209 oral 13:147 oral health care 13:255 orthodontic treatment 13:41,87 osseointegration 13:209 osseous defect 13:139 osteonecrosis 13:231 P peri-implantitis 13:177 periodontal disease 13:147,157,169 periodontal ligament (PDL) 13:75 404 periodontal membrane 13:339 periodontal treatment 13:109,189 periodontal therapy 13:87 periodontitis 13:127 PGE2 13:169 pore interconnectivity 13:247 probing 13:1 R radiography 13:269 recipient site 13:75 regeneration 13:109 retention cyst 13:327 ridge augmentation 13:23,33,57,65,189 ridge preservation 13:65 root resorption 13:41 S sinus augmentation 13:327 schneiderian membrane 13:327 surgical crown lengthening 13:23 T third molar 13:75 treatment planning 13:315 treatment outcome 13:139 thrombocytopenia 13:291 V vitamin 13:147 J Taiwan Periodontol 13. No4. 2008 AUTHORS INDEX C Chan Chiu-Po 13:33,269,301 Chang Jui-Chung 13:315 H Ho Albert Cheng-Sheng Chang Li-Ching 13:99 Ho Cheng-Hsu Chang Wei-Jen 13:339 Ho Kuen-Yen Chen Bor-Jian 13:189 Chen Che-Yi 13:157 Chen Chia-Ching Chen Chih-long 13:23 13:11,51,209,239,315 Chen Chun-Li 13:177 Chen Hen-Li 13:41,139 Chen Jui-Ling 13:41 Chen Min-Chieh Chen Pi-Lun 13:33,269 13:33,57,65 Chen Shyuan-Yow Chen Yen-Hua Ho Ya-Ping Hsieh Yao-Dung 13:291 Chen Chun-Jung 13:109 13:87 Hsieh Yi-Chen Hsu Jen-Hsin Hsu Yueh-Min Hsu Wen-Hsiang Hu Kai-Fang 13:57 13:339 13:279 13:147,157,169,247 J 13:75 Ko Ellen Wen-Ching 13:147,157,169,247 Kung Sue-Fang ,217,247 L Lai Yu-Lin 13:147,157,169,217 Lee Ying-Lin ,247 Li Jui-Kai 13:279 F 13:1,147,157,169,217,247 13:33,269,301 13:65 Kuang Shou-Hsin 13:1,147,157,169 13:1 J Taiwan Periodontol 13. No4. 2008 13:231,291 Huang Ren-Yeong Cheng Chun-Jen G 13:189 13:189 K Fu Earl 13:127 Huang Ming-Hsia 13:315 Chiu Hsien-Chung 13:279 13:11,51,209,239 Cheng Chih-Wen Chih Yu-Kun 13:127,279 Huang Kuo-Ching Ju Yuh-Ren Chiang Cheng-Yang 13:1 13:339 13:157 Cheng Wan-Chien 13:255 Huang Haw-Ming Cheng Chia-Jung Chou Yu-Hsiang 13:1 Gau Ching-Hwa 13:41 13:127,327 13:41,139,189 13:99 13:189 Liang Shih-Yi 13:169 Liao Yu Fang 13:269 Liaw Gwo-An 13:51 Lin Chih-Hao 13:147,169,247 405 Lin Ching-Kai 13:339 Lin Hsiu-Na 13:57 Y Lin Hung-Ta 13:109 Yang Beender Lin Jar-hen Lin Mei-Yin Lin Shih-jung 13:75 13:209 13:23 13:339 Yang Yueh-Chao 13:109 Yeh Hwey-Chin 13:41,139,189 Yen Jui-Ying Lin Yi-Hung 13:231,291 Yuh Lin-Ming Lin Yu-Heng 13:75 W Lin Yu-Ren 13:177 Wang Chen-Ying Liu Che-Yu 13:127 Wang Te-Chou Liu Hung-kai Lo Jyy-Shin Lu Chia-Fang Lu Chun-Tai 13:177 13:217 13:147,169,247 13:65 13:11,239 Yang Jen-Chang Lin Yi-Chun Liu Chin-Lung 13:11,51,209,239 Tseng Chuen-Chyi Wang Yen-Li 13:75 13:139 13:301 13:177 13:327 13:301 Wen Miin-Jye 13:11,239 Wong Huei-An 13:231 Wu Yi-Min 13:279 13:231,291 M Mau Lian-Ping 13:11,239,315 P Pan Yu-Hwa Pan Whei-Lin 13:57,339 13:33,57,65,269,301 Pang Iok-Chao 13:11,239,315 S Shen E-Chih 13:1 T Tai I-Chi Teng Nai-Chia Tong Ching 13:127 13:339 13:87 Tsai Chi-Cheng 13:279 Tsai Kuo-Yang 13:231,291 406 J Taiwan Periodontol 13. 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