Program Book
Transcription
Program Book
TOC2 2006 11/17/05 7:42 AM Page cvr1 ACNP AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY 44th ANNUAL MEETING GENERAL PROGRAM WAIKOLOA, HAWAII HILTON WAIKOLOA VILLAGE DECEMBER 11-15, 2005 TOC2 2006 11/17/05 7:42 AM Page cvr2 TOC2 2006 11/17/05 7:42 AM Page i Table of Contents Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Council . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Program Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Dates and Location . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Book of Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Program Book . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Abstracts-On-Line . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Abstracts-On-CD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Executive Office . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Continuing Medical Education (CME) . . . . . . . . . . . . . . . . . . . . . 4 Meeting Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Scientific Program Videotaping Sessions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Teaching Day . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Hot Topics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Oakley Ray History Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 President’s Plenary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Distinguished Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Issues in Ethics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Panels (times and dates) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Study Groups (times and dates) . . . . . . . . . . . . . . . . . . . . . . . . . 7 Posters Sessions (times and dates) . . . . . . . . . . . . . . . . . . . . . . . 7 Registration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Hotel Facilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Insurance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Refreshments Breaks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Buffet Meals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Reception . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Special Events . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 College Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Committee/Task Force Meetings . . . . . . . . . . . . . . . . . . . . . . . . . 14 Sanctioned Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 i TOC2 2006 11/17/05 7:42 AM Page ii Program Listings Sunday, December 11th Teaching Day . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Hot Topics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Oakley Ray History Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 Monday, December 12th President’s Plenary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Distinguished Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Afternoon Panel Sessions Dopamine Beta Hydroxylase Genetics and Substance Abuse: Of Mice and Men . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Specificity of Cortical GABAergic Systems: Development and Disturbances in Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . 32 Homo- and Hetero-Dimerization of G Protein-Coupled Receptors: Drug Mechanisms and Pharmacological Diversity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Successful Aging: A Neuropsychiatric Entity . . . . . . . . . . . . . . . 34 Towards Building Translational Measures of Depression: Objective Characterizations of Depressive Phenotypes and Biomarkers in Humans and Animals . . . . . . . . . . . . . . . . . . . . . . 35 Effects of Immune Mediators on the Development of Brain Circuits Regulating Cognition and Emotion . . . . . . . . . . . 36 Genes and Brain Development in Health and Illness: The Trajectory is the Story . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 ii TOC2 2006 11/17/05 7:42 AM Page iii Monday, December 12th (cont’d) The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 Study Groups Developing a Consortium and Mechanism to Facilitate the Development of Radiotracers as Useful Biomarkers in Academia and Industry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 J’Accuse: COI in the News, but What of the Accused? . . . . . . . . 40 Tuesday, December 13th Morning Panel Sessions Animal Models of Schizophrenia: Making Progress or Just a Delusion? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Noradrenergic and Dopaminergic Modulation of Prefrontal Cognition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Steroid Hormones and Addiction: From Genes to Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Drug Development: Biomarkers in Alzheimer’s Disease: Early Diagnostic and Treatment Implications . . . . . . . . . . . . . . . 44 The Prefrontal Cortex and Cognitive Flexibility . . . . . . . . . . . . . 45 Stress, Pain and Emotions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 New Neuroimaging Findings in the Pathophysiology and Treatment of Panic Disorder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 iii TOC2 2006 11/17/05 7:42 AM Page iv Tuesday, December 13th (cont’d) ECNP Panel: Bipolar Disorders: European Contributions . . . . . . 48 Issues in Ethics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Afternoon Panel Sessions Lipid Rafts, Caveolin-Related Proteins and Neuronal Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 JSNP Panel: Molecular Mechanisms of Drug Dependence Induced by Amphetamine and Related Drugs . . . . . . . . . . . . . . . 51 What Does Dopamine Say: Clues from Computational Modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 The Role of Feeding Neuropeptides in Alcohol and Drug Dependence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Drug Development: Development of Novel Metabotropic Glutamate Receptor Agents for the Treatment of Schizophrenia and Anxiety-Related Disorders . . . . . . . . . . . . . . . 54 Drug Development: Practical Clinical Trials of Antipsychotic Drugs in Schizophrenia . . . . . . . . . . . . . . . . . . . . . 55 Corticolimbic Changes in Bipolar Disorder: A Developmental Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 Novel Pharmacological Approaches to the Treatment of Drug Addiction: Animal and Human Studies . . . . . . . . . . . . . . . . 57 iv TOC2 2006 11/17/05 7:42 AM Page v Wednesday, December 14th Morning Panel Sessions The Warrior/Worrier Paradox: Varying Allelic Effects and Counter Balancing Selection of Phenotypes . . . . . . . . . . . . . . . . 58 Subregions in the Medial Temporal Lobe: Implications for Normal and Disordered Cognition . . . . . . . . . . . . . . . . . . . . . 59 Drug Development: GSK-3: A Novel Target for Improved Therapeutics for Severe Neuropsychiatric Diseases . . . . . . . . . . 60 Validation of Screening Models for Medications Development to Alcoholism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 Is it Worth the Risks? Treating the Elderly with Antipsychotics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Neuregulin and Schizophrenia: From Genetic Sequence to Pathogenic Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 Animal Models of Deficient Sensorimotor Gating: A New Role for the Corticotropin-Releasing Factor System? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 Afternoon Panel Sessions Molecular Mechanisms of Synaptic Alterations Associated with Neuropsychiatric Disorders and Addiction . . . . . . . . . . . . . 65 Tourette Syndrome-A Window into Neurochemistry and Neuropharmacology of Many Comorbid Neuropsychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66 Drug Development: Advances in Neurotensin Neurobiology: Implications for Novel Treatments for Psychosis and Drug Abuse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 v TOC2 2006 11/17/05 7:42 AM Page vi Wednesday, December 14th (cont’d) Cortical Dopaminergic Neurotransmission and Cognition: Neuroimaging and Physiologic Studies . . . . . . . . . . . . . . . . . . . . 68 Protein Trafficking and Therapeutic Mechanisms for Mood Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 5-HT6 Receptors: New Targets for Neuropsychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Stress in Addiction Relapse: Are There Viable Treatment Targets? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 Thursday, December 15th Morning Panel Sessions Selecting Animal Models to Predict Pro-Cognitive Effects in Human Populations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 Synaptic Plasticity: Focus on the Mechanisms and Clinical Implications of Long-Term Depression . . . . . . . . . . . . . . . . . . . . 73 Advances in Functional Neuroanatomy and Neurochemistry of Resilience . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 If You Prick Them, Do They not Bleed? Emotion Recognition and Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Clock Genes, Melatonin and Affective Disorders . . . . . . . . . . . . 76 The Endocannabinoid System as Target for Drug Discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 A Noradrenergic Focus on Attention and Attention-Deficit Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 vi TOC2 2006 11/17/05 7:42 AM Page vii Thursday, December 15th (cont’d) Teaching Neuropsychopharmacology . . . . . . . . . . . . . . . . . . . 79 Afternoon Panel Sessions Plastic Changes in the Addicted Brain: A Glimpse at the Next Generation of Pharmacotherapies . . . . . . . . . . . . . . . . . . . . 80 Neural Changes in Adolescence and Onset of Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Neuregulin 1 - ErbB4 Signaling in Schizophrenia . . . . . . . . . . . . 82 Drug Development: Novel Insights into the Neurobiology and Treatment of Autism Spectrum Disorders . . . . . . . . . . . . . . . 83 Neural Mechanisms of Extinction: Translating from Rats to Humans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Sex Differences in the Action of Opioids . . . . . . . . . . . . . . . . . . . 85 Whole Genome Association Studies: New Promise for Psychiatric Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 Poster Sessions Poster Session I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Poster Session II . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 Poster Session III . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 Nonmember Participants List . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Hotel Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 Future ACNP Annual Meetings . . . . . . . . . . . . . . Inside Back Cover Summary Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Back Cover vii TOC2 2006 11/17/05 7:42 AM Page viii Front Section 2006.qxp 11/17/05 7:43 AM Page 1 ACKNOWLEDGMENTS The American College of Neuropsychopharmacology gratefully acknowledges the following companies in support of the 44th ACNP Annual Meeting: Bristol-Myers Squibb Company Cyberonics, Inc. Eli Lilly and Company Forest Laboratories GlaxoSmithKline Janssen Pharmaceutica Products, L.P. Otsuka Maryland Research Pfizer Pharmaceuticals Wyeth Pharmaceuticals 1 Front Section 2006.qxp 11/17/05 7:43 AM Page 2 COUNCIL Officers and Council President President-Elect Secretary Treasurer Daniel R. Weinberger Kenneth L. Davis Oakley S. Ray Irwin J. Kopin Council William T. Carpenter, Jr. Dennis S. Charney Michael Davis Ellen Frank Raquel Gur Mary Jeanne Kreek Eric J. Nestler Carol A. Tamminga PROGRAM COMMITTEE 2005 Program and Scientific Communications Committee Chair Co-Chair Council Liaison Trey Sunderland Larry Siever Raquel Gur Members Lori Altshuler Nancy Andreasen Jay Baraban Karen Berman Jacqueline Crawley John Csernansky Steven DeKosky David Goldman Suzanne Haber Dilip Jeste Edward Jones John Krystal Pat Levitt Edythe London Helen Mayberg Bruce McEwen Charles Nemeroff Daniel Pine Judith Rapoport Perry Renshaw Lorna Role Gary Small Rita Valentino Elizabeth Young George Zubenko 2 Front Section 2006.qxp 11/17/05 7:43 AM Page 3 GENERAL INFORMATION Dates and Location Dates Location Sunday, December 11, 2005 - Thursday, December 15, 2005 Hilton Waikoloa Village, Waikoloa, Hawaii Book of Abstracts The abstracts presented at the Annual Meeting will be archival. All scientific registrants will receive a copy of Neuropsychopharmacology, Volume 30, Supplement 1, December 2005 as part of their registration material. Additional copies may be purchased from Nature Publishing Group (http://www.nature.com/npp) for $30.00 each. Program Book All scientific registrants will receive a Program Book as part of their registration material. The Program Book is also available on the ACNP website, www.acnp.org. Abstracts-On-Line All scientific registrants will be able to access the 44th ACNP Annual Meeting Abstracts-On-Line at www.acnp.org. Abstracts-On-CD All scientific registrants will receive the 44th ACNP Annual Meeting Abstracts-on-CD as part of their registration material. ACNP Executive Office ACNP Executive Office 545 Mainstream Drive, Suite 110 Nashville, Tennessee 37228 Phone: 615-324-2360 Fax: 615-324-2361 E-mail: [email protected] 3 Front Section 2006.qxp 11/17/05 7:43 AM Page 4 Continuing Medical Education The 2005 ACNP Annual Meeting is jointly sponsored by the ACNP and Vanderbilt University School of Medicine. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for CME (ACCME) through the joint sponsorship of Vanderbilt University School of Medicine and ACNP. Vanderbilt University School of Medicine is accredited by the Accreditation Council for CME to sponsor continuing medical education for physicians. Vanderbilt School of Medicine designates this educational activity for up to 42.0 Category 1 credits toward the AMA Physician’s Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. There is no charge for scientific registrants to obtain CME credits. Current guidelines of the Accreditation Council for CME require that participants in CME activities must be made aware of any affiliation or financial relationship that might influence a speaker’s presentation(s). To meet these guidelines, each speaker was required to complete a “Financial Disclosure Form.” Information that speakers provide on these forms is included in the appendix of the Program Book. The 2005 ACNP Annual Meeting has been planned to meet the educational needs of the membership of the American College of Neuropsychopharmacology. Invited guests of members and trainees may also attend. Learning Objectives: After participating in the 2005 ACNP Annual Meeting, ACNP members should be able to describe and discuss: • recent theories about the treatment of mental and addictive disorders • recent advances in basic neurosciences that affect the development of new treatments • recent progress in the molecular genetics and molecular biology of mental and addictive disorders • anatomical areas of the brain that are involved in the medication of behavioral states • functional and anatomical brain abnormalities observed in recent studies of mental and addictive disorders CME forms and instructions are included in the meeting registration tote bag. 4 Front Section 2006.qxp 11/17/05 7:43 AM Page 5 Meeting Evaluation All meeting attendees are urged to complete an evaluation of the meeting. Attendees who are requesting CME credit for the meeting a re re q u i red to complete the evaluation. You may complete the evaluation in the ACNP Computer Center in Kona 2 or on-line at www.acnp.org (click Annual Meeting). All evaluations must be completed by January 15, 2006. SCIENTIFIC PROGRAM VIDEOTAPING SESSIONS Attendees may not videotape, audiotape, or photograph (camera or camera phone) presentations at the Annual Meeting without prior permission from the panel chair. PLENARY SESSIONS TEACHING DAY. Teaching Day is organized and chaired by Kenneth Davis, the President-Elect. The topic this year is “Total Glia.” Sunday, December 11th 8:00 a.m. - 12:30 p.m. This session is located in the Monarchy Ballroom. HOT TOPICS. Each presentation should last about ten minutes with a fiveminute period for questions and open discussion. There are two categories: Basic/Translational topics & Clinical topics. The two sessions will be concurrent. Sunday, December 11th 2:30 p.m. - 5:00 p.m. Basic Clinical Kona 5 Kona 4 5 Front Section 2006.qxp 11/17/05 7:43 AM Page 6 OAKLEY RAY HISTORY LECTURE. This will be the first year of the biennial Oakley Ray History Lecture. This lecture will be chaired by Carl Salzman, the History Committee Chair. Andrea Tone will be speaking on “Fifty Years After Miltown: Tranquilizers, History, and Psychiatry.” Sunday, December 11th 7:00 p.m. - 8:00 p.m. This session is located in Kona 4. PRESIDENT’S PLENARY. This year’s President's Plenary, chaired by ACNP President, Daniel Weinberger, is titled “The Complexity of Complex Genetics: Beyond Genes and Environment.” Monday, December 12th 8:00 a.m. - 11:30 a.m. This session is located in the Monarchy Ballroom. DISTINGUISHED LECTURE. This plenary is chaired by Daniel Weinberger. The lecture will be presented by Ronald McKay. The title of his talk is, “Stem Cells Today and Stem Cells Tomorrow.” Monday, December 12th 1:00 p.m. - 2:15 p.m. This session is located in the Monarchy Ballroom. ISSUES IN ETHICS. This year’s topic is “Rethinking Risk in Clinical Research” and is co-chaired by David Rubinow and David Braff. The speakers this year include Paul Andreason, David Brent, James Harris, Lydia Lewis, Jane Pearson, and Donald Rosenstein. Tuesday, December 13th 12:00 p.m. - 2:30 p.m. This session is located in the Monarchy Ballroom. 6 Front Section 2006.qxp 11/17/05 7:43 AM Page 7 CONCURRENT SESSIONS PANELS. The title and location of each Panel is indicated in the Program. The presentations in each session are scheduled at approximately 30-minute intervals, allowing for 20-minute presentations and 10-minute discussion periods. A thirty-minute general discussion period is scheduled after the last presenter in each session. Panels are scheduled: Monday, December 12th 2:30 p.m. - 5:00 p.m. Tuesday, December 13th 8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m. Wednesday, December 14th 8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m. Thursday, December 15th 8:00 a.m. - 10:30 a.m. 2:30 p.m. - 5:00 p.m. STUDY GROUPS. This year will be the first year of Issue Oriented Study Groups. There are two study groups scheduled for Monday evening. The title and location of each Study Group is indicated in the Program. They are: Monday, December 12th 7:45 p.m. - 9:00 p.m. POSTER SESSIONS POSTERS. Poster presentations are grouped by general topic area. Topic areas are sometimes repeated. All three Poster Sessions are located in the Kohala Ballroom. Monday, December 12th 5:30 p.m. - 7:30 p.m. Poster Session I Welcoming Reception Tuesday, December 13th 5:30 p.m. - 7:30 p.m. Poster Session II Reception Wednesday, December 14th 5:30 p.m. - 7:30 p.m. Poster Session III Reception 7 Front Section 2006.qxp 11/17/05 7:43 AM Page 8 REGISTRATION ON-SITE REGISTRATION PERIODS Date Time Location Saturday, December 10th 10:00 a.m. - 6:00 p.m. Kona 3 Sunday, December 11th 7:00 a.m. - 5:00 p.m. Kona 3 Monday, December 12th 7:00 a.m. - 5:00 p.m. Kona 3 Tuesday, December 13th 7:30 a.m. - 5:00 p.m. Kona 3 Wednesday, December 14th 7:30 a.m. - 5:00 p.m. Kona 3 Thursday, December 15th 7:30 a.m. - 3:00 p.m. Kona 3 ON-SITE REGISTRATION FEES Categories On-Site Fee Members of ACNP Members of ECNP, CINP, CCNP, JSNP (on list) Emeritus Corporate Representatives Non-Member Program Participant 2005 Travel Awardees Trainee* Invited Guest Past Travel Awardee (2003-2004) Optional Journal Subscription for non-ACNP members** Accompanying Person*** $450 $450 $250 $650 Waived Waived $250 $650 $250 $100 $125 *A Trainee is a person in a training position and not a full-time, permanent position. A Trainee can be a M.D., Ph.D., Postdoctoral Fellow, or a Resident Research Fellow. Trainees have all the rights and privileges of Invited Guests. **Non-ACNP members may pay $100 extra and receive a 1-year subscription (calendar year 2006) to Neuropsychopharmacology. This is a substantial discount from the normal non-member rate of $245. 8 Front Section 2006.qxp 11/17/05 7:43 AM Page 9 ***An accompanying person is a spouse, relative, or significant other who accompanies an attendee. An accompanying person may only attend the social functions of the meeting, which includes the networking breakfast, morning buffets, lunches, and the closing reception dinner. Accompanying persons are also allowed to attend the poster sessions. Registration fee for scientific registrants includes: - Meeting refreshment breaks - Admission to Teaching Day, Hot Topics, Issues in Ethics Session, President’s Plenary, the Distinguished Lecture, Oakley Ray History Lecture, Teaching Neuropsychopharmacology, all panel & study group sessions - Admission to poster sessions - Admission to the Buffet Luncheons on Monday, Tuesday, Wednesday - Meeting Abstract Book, Program Book, and Abstracts-On-CD - Registration packet containing CME instructions, other meeting materials - Thursday Evening Reception Pre-paid registration will be outside of Waikoloa 1. Hotel Facilities The Hilton Waikoloa Village guest rooms, common areas, and transportation services are in compliance with the public accommodation requirements of the Americans with Disabilities Act. These facilities will be accessible to and usable by individuals with disabilities who attend and participate in the Annual Meeting. Meeting and activity rooms have been designated smoke-free for the duration of the Annual Meeting. Insurance It is highly recommended that all participants carry the proper travel and health insurance as the ACNP cannot accept liability for any accidents or injuries that may occur at the meeting. 9 Front Section 2006.qxp 11/17/05 7:43 AM Page 10 SERVICES ACNP Service Center The “Office Away from the Office” is provided for the convenience of meeting attendees. The Service Center will feature a message center, fax transmissions, and photocopying. Kona 3: Saturday (registration only) Sunday-Monday Tuesday-Wednesday Thursday 10:00 a.m. - 6:00 p.m. 7:00 a.m. - 5:00 p.m. 7:30 a.m. - 5:00 p.m. 7:30 a.m. - 5:30 p.m. ACNP Computer Center The ACNP Computer Center is provided this year for the convenience of meeting attendees. The computers will available for the following: abstractson-CD, e-mail, internet access, and meeting evaluation. Kona 2: Sunday through Wednesday Thursday 7:30 a.m. - 9:00 p.m. 7:30 a.m. - 5:00 p.m. Speaker Ready Room A speaker ready room will be available in Kona 1. The speaker ready room will be open Sunday - Thursday, 6:30 a.m. - 6:00 p.m. Travel Information Desk The Travel Information Desk is located outside of Queen’s 4 and is staffed by Sailair Travel, Inc., the official travel agency for the ACNP. Participants can obtain travel, tour, and car rental information, purchase tickets, and make a variety of other tour and travel arrangements at this desk. REFRESHMENT BREAKS All registered individuals are invited. Coffee and light pastries for registered individuals will be available in Lagoon Lanai the following times: Sunday, Monday, Tuesday, Thursday: Wednesday: 7:00 a.m. 6:45 a.m. 10 Front Section 2006.qxp 11/17/05 7:43 AM Page 11 BUFFET MEALS All registered individuals are invited. Date: Monday, December 12th Time: 11:30 a.m. - 12:45 p.m. Place: Lagoon Lanai Date: Tuesday, December 13th Time: 11:00 a.m. - 12:00 p.m. Place: Lagoon Lanai Date: Wednesday, December 14th Time: 12:00 p.m. - 1:00 p.m. Place: Lagoon Lanai ACNP RECEPTION All registered individuals are invited. Date: Thursday, December 15th Time: 7:30 p.m. - 10:30 p.m. Place: Monarchy Ballroom SPECIAL EVENTS Saturday, December 10, 2005 Travel Award Breakfast (by invitation only) Time: 6:00 p.m. - 7:30 p.m. Place: Water’s Edge Ballroom 11 Front Section 2006.qxp 11/17/05 7:43 AM Page 12 Sunday, December 11, 2005 Travel Award Breakfast (by invitation only) Time: 7:00 a.m. - 8:00 a.m. Place: Water’s Edge Ballroom Past Presidents’ Luncheon (by invitation only) Time: 12:30 p.m. - 2:00 p.m. Place: Water’s Edge Boardroom Monday, December 12, 2005 Informal Networking Session for Spouses/Guests of Attendees See flyer in registration tote bag Time: 9:00 a.m. - 11:00 a.m. Place: Kona 5 Media Training Session Time: 7:30 p.m. - 10:00 p.m. Place: Queen’s 6 Wednesday, December 14, 2005 Town Hall Meeting: Clinical Trials Registry & U.S. Drug Surveillance System Time: 7:00 a.m. - 8:00 a.m. Place: Kona 4 Travel Award Luncheon (by invitation only) Time: 12:00 p.m. - 2:00 p.m. Place: Water’s Edge Ballroom Memorial Symposium Time: 1:00 p.m. - 2:15 p.m. Place: Queen’s 6 12 Front Section 2006.qxp 11/17/05 7:43 AM Page 13 Thursday, December 15, 2005 Teaching Neuropsychopharmacology Time: 12:30 p.m. - 2:00 p.m. Place: Kona 5 COLLEGE MEETINGS Monday, December 12, 2005 Neuropsychopharmacology Editorial Board Time: 11:30 a.m. - 12:45 p.m. Place: Kona 4 Tuesday, December 13, 2005 Corporate Liaison Meeting Time: 11:00 a.m. - 12:00 p.m. Place: Water’s Edge Ballroom Wednesday, December 14, 2005 Annual Business Meeting (ACNP Scientific Members only) Chair: Daniel Weinberger Time: 10:45 a.m. - 11:45 a.m. Place: Kona 4 13 Front Section 2006.qxp 11/17/05 7:43 AM Page 14 Council Meetings Council is involved in many activities during the Annual Meeting. The official Council meetings are listed below: Saturday, December 10, 2005 ACNP Council Time: 8:00 a.m. - 3:00 p.m. Place: Water’s Edge Ballroom Tuesday, December 13, 2005 2005 Committee Chairs - Reports to Council Time: 6:00 p.m. - 11:00 p.m. Place: Water’s Edge Ballroom Thursday, December 15, 2005 2006 Committee Chairs & ACNP Council Time: 11:00 a.m. - 1:00 p.m. Place: Water’s Edge Ballroom COMMITTEE/TASK FORCE MEETINGS Meetings listed below are as scheduled by the Committee Chairs. Committee meetings, Task Force meetings, and activities not listed here will be posted at the ACNP Registration Desk. Saturday, December 10, 2005 Credentials Committee Time: 8:15 a.m. - 5:30 p.m. Place: Kona 5 Animal Committee Time: 10:00 a.m. – 12:00 p.m. Place: Waikoloa 3 Constitution & Rules Committee Time: 10:30 a.m. - 11:30 a.m. Place: Waikoloa 2 14 Front Section 2006.qxp 11/17/05 7:43 AM Page 15 Saturday, December 10, 2005 (cont’d) Ethics Committee Time: 1:00 p.m. - 3:00 p.m. Place: Queen’s 6 Medication Development Task Force Time: 1:30 p.m. - 3:00 p.m. Place: Queen’s 5 Advocacy Committee/Advocacy Affiliates/Coalition for Mental Health Research Time: 2:00 p.m. - 3:30 p.m. Place: Kohala 2 Human Research Committee Time: 2:00 p.m. - 4:00 p.m. Place: Waikoloa 2 Liaison Committee Time: 3:00 p.m. - 5:00 p.m. Place: Kohala 1 Publications Committee Time: 3:30 p.m. - 5:00 p.m. Place: King’s 3 Finance Committee Time: 3:30 p.m. - 5:30 p.m. Place: King’s 2 Education & Training Committee Time: 4:00 p.m. - 6:00 p.m. Place: Kona 4 Public Information Committee Time: 4:30 p.m. - 6:30 p.m. Place: Queen’s 4 15 Front Section 2006.qxp 11/17/05 7:43 AM Page 16 Sunday, December 11, 2005 2006 Nominating Committee Time: 12:30 p.m. - 2:30 p.m. Place: TBA Monday, December 12, 2005 Program Committee Time: 11:30 a.m. - 12:45 p.m. Place: Water’s Edge Ballroom The History Task Force will be video taping interviews by appointment in Waikoloa 3. ACNP SANCTIONED MEETINGS (These Sanctioned Meetings are closed meetings.) TURNS SOU Compound Selection Meeting Date: Saturday, December 10, 2005 Time: 8:00 a.m. - 5:00 p.m. Place: Water’s Edge Boardroom NIDA Workshop Date: Saturday, December 10, 2005 Time: 8:30 a.m. - 5:00 p.m. Place: Kohala 3 CDI Booster Session Date: Saturday, December 10, 2005 Time: 1:30 p.m. - 6:00 p.m. Place: Kohala 4 Date: Sunday, December 11, 2005 Time: 12:30 p.m. - 2:30 p.m. Place: Kohala 4 16 Front Section 2006.qxp 11/17/05 7:43 AM Page 17 SBP Council Date: Saturday, December 10, 2005 Time: 4:00 p.m. - 9:00 p.m. Place: King’s 1 P rogram Committee Date: Wednesday, December 14, 2005 Time: 11:45 a.m. - 1:30 p.m. Place: Monarchy Ballroom (dancefloor area) Emory-GSK-NIMH Steering Committee Date: Sunday, December 11, 2005 Time: 12:30 p.m. - 2:30 p.m. Place: Waikoloa 2 Duke Clinical Research Institute Private Function Date: Sunday, December 11, 2005 Time: 8:00 p.m. - 10:00 p.m. Place: Waikoloa 2 Date: Monday, December 12, 2005 Time: 9:00 p.m. - 11:00 p.m. Place: Waikoloa 2 Date: Wednesday, December 14, 2005 Time: 7:00 p.m. - 11:00 p.m. Place: Water’s Edge Boardroom Academic Consortium Meeting Date: Wednesday, December 14, 2005 Time: 12:00 p.m. - 1:15 p.m. Place: Waikoloa 2 17 Front Section 2006.qxp 11/17/05 7:43 AM Page 18 Front Section 2006.qxp 11/17/05 7:43 AM Page 19 In Memoriam Ernest Sigg October 12, 2004 Julius Axelrod December 29, 2004 Peter Stokes January 22, 2005 C. Jelleff Carr February 15, 2005 David Segal August 23, 2005 Mogens Schou September 29, 2005 Frederic Quikin October 9, 2005 Front Section 2006.qxp 11/17/05 7:43 AM Page 20 Front Section 2006.qxp 11/17/05 7:43 AM Page 21 ACNP 44th Annual Meeting Scientific Program Legends for tabs PA-Panel PL-Plenary Session SG-Study Group Front Section 2006.qxp 11/17/05 7:43 AM Page 22 plenaries 2006.qxp 11/17/05 7:44 AM Page 23 8:00 AM - 12:30 PM Teaching Day Monarchy Ballroom Teaching Day Su PL Total Glia Chair: Kenneth L. Davis 8:00 a.m. Welcome and Introduction Kenneth L. Davis 8:10 a.m. Glial Cells of Mammalian CNS James E. Goldman 8:50 a.m. Neuron-Glia Metabolic Coupling and its Relevance for Functional Brain Imaging in Neuropsychiatry Pierre J. Magistretti 9:30 a.m. Oligodendrocytes and Myelination Bruce D. Trapp 10:10 a.m. Break 10:30 a.m. Involvement of Glial Cells in the Pathophysiology and Treatment of Severe Mood Disorders Husseini K. Manji 11:10 a.m. White Matter Abnormalities in Schizophrenia Joseph D. Buxbaum 11:50 a.m. Derivation of High Purity Neural Lineages from Human Embryonic Stem Cells Hans Keirstead 23 plenaries 2006.qxp 11/17/05 7:44 AM Page 24 2:30 - 5:00 PM Hot Topics - Basic Kona 5 Su Hot Topics PL Basic/Translational Chair: Larry Siever 2:30 p.m. Distinct Roles for Different Homer1 Isoforms in Behaviors Associated with Prefrontal Cortex Function in vivo Karen Szumlinski 2:45 p.m. Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer’s Disease Are Reversed by Inhibition of Gamma Secretase Menelas Pangalos 3:00 p.m. Insulin And Igf-1 Reverse Mitochondrial, Energy Metabolism, Proteasome, And Neuronal Plasticity Gene Decreases Of Schizophrenia In An Mrna-Based Screen For Antischizophrenia Agents C. Altar 3:15 p.m. Casein Kinase 1 Epsilon Modulates Sensitivity to Stimulant Drugs in Both Mice and Humans: A Translational Genetic Study Abraham Palmer 3:30 p.m. Histone Hyper-Acetylation Enhances Memory Storage and Facilitates Synaptic Plasticity via the Transcription Factor CREB Ted Abel 24 plenaries 2006.qxp 11/17/05 7:44 AM Page 25 2:30 - 5:00 PM Hot Topics - Basic Kona 5 Hot Topics Su PL Basic/Translational Chair: Larry Siever 3:45 p.m. Neural Correlates of Anxiety in Serotonin 1A Receptor-Deficient Mice Joshua Gordon 4:00 p.m. MUTED (6p24.3), a Protein That Binds to Dysbindin (DTNBP1, 6p22.3), Is Strongly Associated with Schizophrenia and Exhibits Statistical Epistasis with COMT Richard Straub 4:15 p.m. Electroconvulsive Seizures Increase Cell Proliferation in the Adult Monkey Cortex Tarique Perera 4:30 p.m. COMT Inhibition Enhances Neuregulin-Induced Cell Migration in B Lymphoblasts Elizabeth Tunbridge 4:45 p.m. Engraftment of a Monoaminergic Cell Line within Affective Neural Circuitry Miles Cunningham 25 plenaries 2006.qxp 11/17/05 7:44 AM Page 26 2:30 - 5:00 PM Hot Topics - Clinical Kona 4 Su Hot Topics PL Clinical Chair: Trey Sunderland 2:30 p.m. Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle 2:45 p.m. Early Postnatal Brain Structure and Development in Humans: Sexual Dimorphism and Cerebral Asymmetry are Present at Birth John Gilmore 3:00 p.m. Oxytocin Increases Social Cognition in Autism Eric Hollander 3:15 p.m. Influence of Low and High Dose Hydrocortisone Infusion on Hemodynamic Response in Amygdala While Viewing Emotional Faces Kristine Erickson 3:30 p.m. Distribution of [11C]PIB in a Nondemented Population: Implication for Use as an Antecedent Marker of Alzheimer’s Disease Mark Mintun 26 plenaries 2006.qxp 11/17/05 7:44 AM Page 27 2:30 - 5:00 PM Hot Topics - Clinical Kona 4 Hot Topics Su PL Clinical Chair: Trey Sunderland 3:45 p.m. Glutamate Transporter Gene (SLC1A1) Associated with Obsessive Compulsive Disorder Paul Arnold 4:00 p.m. Frontal Dopamine D2 Receptor Binding in Neuroleptic-Naive First-Episode Schizophrenic Patients Correlates with Positive Psychotic Symptoms and Predicts Treatment Outcome Birte Glenthoj 4:15 p.m. The Trajectory is The Story: Cortical Gray Matter Changes During Adolescence In Childhood Onset Schizophrenia Evolve Into The Adult Pattern By Age 25 Nitin Gogtay 4:30 p.m. Corollary Discharge Failure in Schizophrenia is Related to Severity of Auditory Hallucinations: fMRI Evidence Judith Ford 4:45 p.m. Robust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A DoubleBlind Placebo-Controlled Study Carlos Zarate 27 plenaries 2006.qxp 11/17/05 7:44 AM Page 28 7:00 - 8:00 PM Oakley Ray History Lecture Kona 4 Su PL Oakley Ray History Lecture Fifty Years After Miltown: Tranquilizers, History, and Psychiatry Chair: Carl Salzman Presented by Andrea Tone Canada Research Chair in the Social History of Medicine Social Studies of Medicine & Department of History McGill University 28 plenaries 2006.qxp 11/17/05 7:44 AM Page 29 8:00 - 11:30 AM President’s Plenary Monarchy Ballroom President's Plenary Welcoming Remarks and Moment of Silence Daniel Weinberger President Mo PL Presentation of Honorific Awards and Media Award Carol Tamminga Chair, Honorific Awards Committee The Complexity of Complex Genetics: Beyond Genes and Environment Chair: Daniel Weinberger 8:30 a.m. Lessons from Mendelian Genetics About the Mistakes Not to Make Michael Dean 9:15 a.m. Genetics of Addictions: From Behavior to Genetic Architecture, and Back David Goldman 10:00 a.m. Imaging Genetics: Mapping the Mechanisms from Genes to Circuits to Behavior Andreas Meyer-Lindenberg 10:45 a.m. The Long Term Neurobiological Consequences of Stress in Early Life: Gene-Environment Interactions in the Real World Charles Nemeroff 29 plenaries 2006.qxp 11/17/05 7:44 AM Page 30 1:00 - 2:15 PM Distinguished Lecture Monarchy Ballroom Mo PL Distinguished Lecture Stem Cells Today and Stem Cells Tomorrow Chair: Daniel Weinberger Presented by Ronald D.G. McKay Chief, Laboratory of Molecular Biology National Institute of Neurological Disorders and Stroke National Institutes of Health 30 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 31 2:30 - 5:00 PM Dopamine Beta Hydroxylase & Substance Abuse King’s 2 Dopamine Beta Hydroxylase Genetics and Substance Abuse: Of Mice and Men Chair: Co-Chair: 2:30 p.m. Joseph Cubells Thomas Kosten Human Genetics of Plasma DBH Activity in Cocaine Dependence Joseph Cubells Mo PA 3:00 p.m. Dopamine Beta-Hydroxylase Knockout Mice Have Alterations in Dopamine Signaling and Are Hypersensitive to Cocaine Locomotion, Reward, and Aversion David Weinshenker 3:30 p.m. DBH Genotype and Human Self-Administration of Cocaine Robert Malison 4:00 p.m. Norepinephrine in Opiate Reward, Locomotion, and Withdrawal: Evidence for Distinct Contributions by the Locus Coeruleus and the Nucleus Tractus Solitarius Valerie Olson 4:30 p.m. Discussion 31 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 32 2:30 - 5:00 PM Cortical GABAergic Systems in Schizophrenia Kona 4 Specificity of Cortical GABAergic Systems: Development and Disturbances in Schizophrenia Chair: Co-Chair: David Lewis John Krystal 2:30 p.m. Fate Determination of Cortical Interneurons. It Is Who You Are, Not How You Get There Stewart Anderson 3:00 p.m. Regulation of Axon Growth and Inhibitory Synapses Formation by GAD67-Mediated GABA Signaling: Implications in Schizophrenia Pathogenesis Z. Josh Huang 3:30 p.m. Differential Vulnerability of Specific Cortical GABA Systems in Schizophrenia David Lewis 4:00 p.m. New Clinical Evidence Implicating GABA Systems in Psychosis and Cognition: Implications for Schizophrenia John Krystal 4:30 p.m. Discussion Mo PA 32 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 33 2:30 - 5:00 PM G Protein-Coupled Receptors King’s 1 Homo- and Hetero-Dimerization of G Protein-Coupled Receptors: Drug Mechanisms and Pharmacological Diversity Chair: 2:30 p.m. 3:00 p.m. Jonathan Javitch Functional and Pharmacological Consequences of Oligomeric Assemblies in G-Protein-Coupled Receptor Signalling Mo Michel Bouvier PA Hetero-Dimerization of CNS Expressed G ProteinCoupled Receptors: Implications for Drug Function Graeme Milligan 3:30 p.m. Role of GPCR Oligomerization in Regulating Receptors by Endocytic Membrane Trafficking Mark von Zastrow 4:00 p.m. Crosstalk in G Protein-Coupled Receptors: Changes at the Transmembrane Homodimer Interface Determine Activation Jonathan Javitch 4:30 p.m. Discussion 33 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 34 2:30 - 5:00 PM Successful Aging King’s 3 Successful Aging: A Neuropsychiatric Entity Chair: Co-Chair: 2:30 p.m. Mo Dilip Jeste Trey Sunderland A Psycho-Bio-Social Study of Successful Aging Among Community-Dwelling Seniors Dilip Jeste PA 3:00 p.m. Genome Survey for Loci that Influence Successful Aging George Zubenko 3:30 p.m. Neurodegeneration and Regeneration in the Aging Nervous System Laura Dugan 4:00 p.m. Effects of a 14-Day Healthy Aging Lifestyle Program on Brain Function Gary Small 4:30 p.m. Discussion 34 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 35 2:30 - 5:00 PM Translational Measures of Depression Kona 5 Towards Building Translational Measures of Depression: Objective Characterizations of Depressive Phenotypes and Biomarkers in Humans and Animals Chair: Co-Chair: 2:30 p.m. Athina Markou Diego Pizzagalli Objective Measures of Core Cognitive Symptoms of Depression Barbara Sahakian 3:00 p.m. Laboratory Measures of Anhedonia in Humans: A Signal Detection Approach Diego Pizzagalli 3:30 p.m. Measuring Anhedonia in Animals: Reversal by Antidepressant Treatments Athina Markou 4:00 p.m. Long-Term Neurobehavioural Effects of Early Life Adversity in Rats and Monkeys with Relevance to Depression Joram Feldon 4:30 p.m. Discussion 35 Mo PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 36 2:30 - 5:00 PM Immune Mediators on Brain Circuits Queen’s 4 Effects of Immune Mediators on the Development of Brain Circuits Regulating Cognition and Emotion Chair: Co-Chair: Lois Winsky Mark Geyer 2:30 p.m. The Effects of Prenatal Infection on Mechanisms Critical for Cortical Development John Gilmore 3:00 p.m. Sensorimotor Gating Deficits in Rodent Developmental Models Related to Psychotic Disorders Mark Geyer 3:30 p.m. The Impact of Infection Early in Life on the Formation of Long-Term Memories in Adulthood Steven Maier 4:00 p.m. Maternal Influenza Infection Leads to Neuropathology and Behavioral Abnormalities in Adult Offspring Paul Patterson 4:30 p.m. Discussion Mo PA 36 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 37 2:30 - 5:00 PM Genes and Brain Development Queen’s 6 Genes and Brain Development in Health and Illness: The Trajectory is the Story Chair: Co-Chair: 2:30 p.m. Jay Giedd Judith Rapoport The Genetics of Cerebral Cortex Development in the Mouse Susan McConnell Mo PA 3:00 p.m. Searching for the Cause of Dyslexia: To Gel and Bac Albert Galaburda 3:30 p.m. Trajectories of Anatomic Brain Development in Children and Adolescents Jay Giedd 4:00 p.m. Genes, Brain Development and Clinical Outcome in Children with Attention Deficit/Hyperactivity Disorder (ADHD) Philip Shaw 4:30 p.m. Discussion 37 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 38 2:30 - 5:00 PM Phase IV Studies & Off-Label Prescribing Queen’s 5 The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice Chair: Co-Chair: 2:30 p.m. Mo PA 3:00 p.m. Roger Meyer Alexander Glassman Dealing with the Challenging Legal Environment for Phase IV Clinical Trials and Off-Label Prescribing Sandra Johnson The Changing Legal Environment Around Phase IV Studies: The Industry Response Dave Ceryak & Doug Snyder 3:30 p.m. Reporting of Phase 4 Studies in Scholarly Journals Richard Glass 4:00 p.m. The Future of Phase IV Studies and Off-Label Prescribing: The Conundrum Facing Corporate Sponsors of Research, Regulators, Clinical Investigators and the Future of Psychiatric Practice David Meltzer 4:30 p.m. Discussion/Response Panel: Paul Andreason, Donald Klein, Charles O’Brien 38 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 39 7:45 - 9:00 PM Development of Radiotracers as Useful Biomarkers Queen’s 4 Developing a Consortium and Mechanism to Facilitate the Development of Radiotracers as Useful Biomarkers in Academia and Industry Chair: Dean F. Wong Co-Chairs: Linda Brady Robert Innis Participants: Donald Burns Lars Farde Colin Fish Richard Frank Paul Gaylo Hartmuth Kolb Timothy McCarthy Steven Paul William Potter Mark Schmidt Jill Sorensen 39 Mo SG pnls-sg 2006.qxp 11/17/05 7:45 AM Page 40 7:45 - 9:00 PM J’Accuse: COI in the News, but What of the Accused? Queen’s 5 J’Accuse: COI in the News, but What of the Accused? Chair: Mo Daniel R. Weinberger Participants: Alan Breier William Carpenter Ezekiel Emanuel Jack Gorman Robert Muse Jamie Talan Daniel Weinberger SG 40 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 41 8:00 - 10:30 AM Animal Models of Schizophrenia Kona 4 Animal Models of Schizophrenia: Making Progress or Just a Delusion? Chair: Co-Chair: 8:00 a.m. 8:30 a.m. Barbara Lipska Shitij Kapur Morphological and Molecular Changes in the Prefrontal Cortex of Rats Following Neonatal Ventral Hippocampus Damage Lalit Srivastava Genetic Animal Models of Psychosis: The Dopamine/Glutamate Interaction Marc Caron 9:00 a.m. New Genetic Mouse Models of Schizophrenia: Mimicking Cognitive Dysfunction by Altering Susceptibility Gene Expression Jingshan Chen 9:30 a.m. Modelling Antipsychotic Action - Convergence from Studies of Mice and Men Shitij Kapur 10:00 a.m. Discussion 41 Tu PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 42 8:00 - 10:30 AM Noradrenergic & Dopaminergic of Cognition Kona 5 Noradrenergic and Dopaminergic Modulation of Prefrontal Cognition Chair: Co-Chair: Larry Siever Daniel Weinberger 8:00 a.m. Amygdala Modulation of Conditioning within the Prefrontal Cortex is Dependent on Cannabinoid and Dopamine D4 Receptor Activation Anthony Grace 8:30 a.m. Relative Roles for Dopamine and Norepinephrine in Attentional Function and the Behavioral Effects of Methylphenidate and Other Therapeutic Agents for ADHD Trevor Robbins 9:00 a.m. Noradrenergic and Dopaminergic Interventions in the Schizophrenia Larry Siever 9:30 a.m. COMT in Prefrontal Cortex and Beyond: Genetic Studies of Cortical DA Signaling Daniel Weinberger 10:00 a.m. Discussion Tu PA 42 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 43 8:00 - 10:30 AM Steroid Hormones & Addiction King’s 2 Steroid Hormones and Addiction: From Genes to Behavior Chair: Co-Chair: Daniel Dorsa Jill Becker 8:00 a.m. Effects of Estrogen in the Brain: Roles of ER Alpha and Beta in Neurons and Glia Daniel Dorsa 8:30 a.m. Sex Differences and Influences of Steroid Hormones in Drug Abuse Jill Becker Tu PA 9:00 a.m. Steroid Hormones, DARPP-32 and Signal Integration Mechanisms in Brain and Behavior Shaila Mani 9:30 a.m. Anabolic Steroid Addiction? Insights from Animal Studies Ruth Wood 10:00 a.m. Discussion 43 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 44 8:00 - 10:30 AM Biomarkers in Alzheimer’s Disease King’s 3 Drug Development Biomarkers in Alzheimer’s Disease: Early Diagnostic and Treatment Implications Chair: Co-Chair: Trey Sunderland George Zubenko 8:00 a.m. D10S1423 Identifies Susceptibility Locus AD7 for Alzheimer’s Disease in a Prospective, Longitudinal, Double-Blind Study of Asymptomatic Individuals George Zubenko 8:30 a.m. Cerebrospinal Fluid Peptides as Biomarkers for Presymptomatic AD in “At Risk” Controls Trey Sunderland 9:00 a.m. Antecedent Biomarkers for Alzheimer’s Disease John Morris 9:30 a.m. CSF Biomarkers Add to Delayed Recall and Hippocampal Volume in Diagnosing MCI Mony de Leon 10:00 a.m. Discussion Tu PA 44 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 45 8:00 - 10:30 AM Prefrontal Cortex & Cognitive Flexibility King’s 1 The Prefrontal Cortex and Cognitive Flexibility Chair: Co-Chair: Daniel Pine Ellen Leibenluft 8:00 a.m. Reversal Learning in Primates: A Neuroanatomical, Neurochemical and Behavioral Analysis Angela Roberts 8:30 a.m. The Primate Prefrontal Cortex and the Executive Control of Attention Leslie Ungerleider 9:00 a.m. The Prefrontal Cortex and Cognitive Flexibility Cameron Carter 9:30 a.m. Response Flexibility in Bipolar Disorder: A Developmental Perspective Ellen Leibenluft 10:00 a.m. Discussion 45 Tu PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 46 8:00 - 10:30 AM Stress, Pain and Emotions Queen’s 5 Stress, Pain and Emotions Chair: Co-Chair: Charles Nemeroff Emeran Mayer 8:00 a.m. Brain Systems Regulating the Organism’s Response to Stress: Preclinical and Clinical Studies Charles Nemeroff 8:30 a.m. Chronic Pain and Depression Alan Schatzberg 9:00 a.m. Irritable Bowel Syndrome: Brain Mechanisms Involved in the Generation of Chronic Visceral Pain and How Emotions and Cognitions Can Alter Normal Processing of Visceral Stimuli Emeran Mayer 9:30 a.m. Fibromyalgia: Brain Mechanisms Involved in the Generation of Chronic Somatic Pain and How Somatic Pain Processing is Altered in the Setting of Altered Mood and Cognitions Daniel Clauw 10:00 a.m. Discussion Tu PA 46 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 47 8:00 - 10:30 AM Neuroimaging Findings & Panic Disorder Queen’s 4 New Neuroimaging Findings in the Pathophysiology and Treatment of Panic Disorder Chair: Co-Chair: Scott Rauch Jack Gorman 8:00 a.m. Functional Magnetic Resonance Imaging Studies of Amygdalo-Cortical Function in Panic Disorder Scott Rauch 8:30 a.m. Functional Magnetic Resonance Imaging of Attention and Emotion Recognition in Panic Disorder Srinivasan Pillay 9:00 a.m. fMRI Studies of Fronto-Limbic Fear Circuitry in Panic Tu Disorder David Silbersweig PA Regional Metabolic Brain Activation in Patients with Panic Disorder During Doxapram Infusion Jack Gorman 9:30 a.m. 10:00 a.m. Discussion 47 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 48 8:00 - 10:30 AM Bipolar Disorders: European Contributions Queen’s 6 ECNP Panel Bipolar Disorders: European Contributions Chair: Co-Chair: David Nutt Guy Goodwin 8:00 a.m. Exploring the Endophenotype in Bipolar Disorder Guy Goodwin 8:30 a.m. Diagnosis of Bipolar Disorder in Children and Adults (A European Perspective) Jan Buitelaar 9:00 a.m. A Critical Analysis of the Value of Psychoeducation in Bipolar Disorder Eduard Vieta Tu PA 9:30 a.m. 10:00 a.m. The Treatment of Depression in Bipolar Disorder (An European Perspective) Heinz Grunze Discussion 48 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 49 12:00 - 2:30 PM Issues in Ethics Monarchy Ballroom Issues in Ethics Rethinking Risk in Clinical Research Chair: Co-Chair: David Rubinow David Braff Donald Rosenstein Acting Clinical Director National Institute of Mental Health National Institutes of Health Jane Pearson Acting Deputy Director Division of Services and Intervention Research National Institute of Mental Health National Institutes of Health Lydia Lewis President The Depression and Bipolar Support Alliance James Harris Director, Developmental Neuropsychiatry Johns Hopkins University School of Medicine David Brent Academic Chief Child and Adolescent Psychiatry Western Psychiatric Institute and Clinic Paul Andreason Acting Deputy Director Division of Psychiatric Products Food and Drug Administration 49 Tu PL pnls-sg 2006.qxp 11/17/05 7:45 AM Page 50 2:30 - 5:00 PM Lipid Rafts, Caveolae & Signal Transduction King’s 3 Lipid Rafts, Caveolin-Related Proteins and Neuronal Signaling Chair: Co-Chair: Bryan Roth Mark Rasenick 2:30 p.m. Caveolin: A Novel Regulator of GPCR Signaling Bryan Roth 3:00 p.m. Caveolin-1 Interacts with Metabotropic Glutamate Receptors and Participates in Receptor Trafficking Anna Francesconi 3:30 p.m. Agonist-Induced Lipid Raft Trafficking and Subsequent Internalization of G alpha s Regulates cAMP Signaling Mark Rasenick Tu PA 4:00 p.m. 4:30 p.m. Lipid Rafts and Neural Cell Adhesion Molecules in Axon Growth Vance Lemmon Discussion 50 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 51 2:30 - 5:00 PM Molecular Mechanisms of Drug Dependence Queen’s 4 JSNP Panel Molecular Mechanisms of Drug Dependence Induced by Amphetamine and Related Drugs Chair: Co-Chair: Toshitaka Nabeshima Edward Domino 2:30 p.m. Overview 2:35 p.m. Candidate Gene Analysis of MethamphetamineRelated Disorders Hiroshi Ujike 3:00 p.m. Brain Imaging Reveals Corticolimbic Dysregulation in Methamphetamine Abusers Tu Edythe London 3:25 p.m. Mesolimbic Dopamine D2/D3 Receptor-Mediated Signaling in Methamphetamine-Sensitized Rats Jin-Chung Chen 3:50 p.m. The Role of Tissue Plasminogen Activator in Methamphetamine-Related Reward and Sensitization Kiyofumi Yamada 4:15 p.m. Serotonin Modulation of the Effects of Amphetamine and Phencyclidine: Locomotor Hyperactivity and Prepulse Inhibition Studies in Rats Maarten van den Buuse 4:40 p.m. Question and Answer 51 PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 52 2:30 - 5:00 PM Dopamine & Computational Modeling King’s 1 What Does Dopamine Say: Clues from Computational Modeling Chair: Co-Chair: Tu Steven Grant Jonathan Cohen 2:30 p.m. The Role of Dopamine in the Temporal Difference Model of Reinforcement Learning Read Montague 3:00 p.m. Dopamine Encodes a Quantiative Reward Prediction Error for Reinforcement Learning Paul Glimcher 3:30 p.m. Implications of the Temporal Difference Reinforcement Learning Model for Addiction and Relapse A. David Redish 4:00 p.m. Dopamine-Norepinephrine Interactions: Exploitation versus Exploration Jonathan Cohen 4:30 p.m. Discussion PA 52 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 53 2:30 - 5:00 PM Feeding Neuropeptides & Drug Dependence Queen’s 6 The Role of Feeding Neuropeptides in Alcohol and Drug Dependence Chair: Co-Chair: Michael Lewis George Koob 2:30 p.m. Galanin and Opioid Peptides in Relation to Alcohol Intake and Dietary Fat: Possible Positive Feedback Mechanisms Sarah Leibowitz 3:00 p.m. Neuropeptide Y and Melanocortin Neuropeptides Regulate Alcohol Intake and Feeding: Are Overlapping Pathways Involved? Todd Thiele 3:30 p.m. Not Your Mother’s CRF: Type 2 Urocortins, Selective CRF2 Receptor Agonists, Reduce Excessive Ethanol Drinking and Overeating George Koob 4:00 p.m. Sugar Bingeing Produces Effects on Opioid and Dopamine Systems: Possible Roles in Drug Abuse Bartley Hoebel 4:30 p.m. Discussion 53 Tu PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 54 2:30 - 5:00 PM Novel Metabotropic Glutamate Receptor Agents Kona 5 Drug Development Development of Novel Metabotropic Glutamate Receptor Agents for the Treatment of Schizophrenia and Anxiety-Related Disorders Chair: Co-Chair: Athina Markou Anne Lesage 2:30 p.m. Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5: A New Generation of Antipsychotics? Vincent Mutel 3:00 p.m. Description of a Clinically Validated Anxiolytic with mGlu5 Antagonist Properties Richard Porter Tu PA 3:30 p.m. Anxiolytic and Cognitive Properties of the mGlu1 Receptor Negative Allosteric Modulator JNJ16259685 Anne Lesage 4:00 p.m. mGluR7: A Novel Therapeutic Target for StressRelated Disorders John F. Cryan 4:30 p.m. Discussion 54 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 55 2:30 - 5:00 PM Practical Clinical Trials of Antipsychotic Drugs Kona 4 Drug Development Practical Clinical Trials of Antipsychotic Drugs in Schizophrenia Chair: Co-Chair: Jeffrey Lieberman Susan Essock 2:30 p.m. First Generation versus Second Generation (non-clozapine) Antipsychotic Drugs versus Clozapine in Schizophrenia: The CUtLASS Trials Shon Lewis 3:00 p.m. Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia: Primary Efficacy and Safety Outcomes of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Tu Trial Jeffrey Lieberman PA 3:30 p.m. Effectiveness of Antipsychotic Drugs in Unresponsive and Intolerant Patients Joseph McEvoy 4:00 p.m. Cost-Effectiveness of Atypical Antipsychotics in the CATIE Schizophrenia Trial Robert Rosenheck 4:30 p.m. Discussion 55 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 56 2:30 - 5:00 PM Corticolimbic Changes in Bipolar Disorder King’s 2 Corticolimbic Changes in Bipolar Disorder: A Developmental Perspective Chair: Co-Chair: Tu Caleb Adler Stephen Strakowski 2:30 p.m. Prefrontal-Amygdalar Abnormalities in Pediatric Bipolar Disorder Kiki Chang 3:00 p.m. Progression of Anterior Limbic Dysfunction in Adolescent Bipolar Disorder Melissa DelBello 3:30 p.m. Multimodality Magnetic Resonance Imaging Evidence for Abnormalities in Cortico-limbic Structural and Functional Connectivity in Bipolar Disorder Hilary Blumberg 4:00 p.m. Complementary Morphometric and Functional Corticolimbic Changes in Adult Bipolar Patients Caleb Adler 4:30 p.m. Discussion PA 56 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 57 2:30 - 5:00 PM Drug Addiction: Novel Pharmacological Approaches Queen’s 5 Novel Pharmacological Approaches to the Treatment of Drug Addiction: Animal and Human Studies Chair: Co-Chair: Charles O’Brien Laura Peoples 2:30 p.m. The Differential Neuroplasticity and Differential Inhibition Hypotheses of Drug Addiction: Empirical Evidence and Implications for Treatment Laura Peoples 3:00 p.m. Novel Pharmacological Targets for Relapse Prevention: Animal Studies Friedbert Weiss 3:30 p.m. Regulating Glutamate Homeostasis in Treating Cocaine Addiction Peter Kalivas 4:00 p.m. Translating Data from Animal Models to New Treatments for Addiction Charles O’Brien 4:30 p.m. Discussion 57 Tu PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 58 8:00 - 10:30 AM The Warrior/Worrier Paradox King’s 1 The Warrior/Worrier Paradox: Varying Allelic Effects and Counter Balancing Selection of Phenotypes Chair: Co-Chair: 8:00 a.m. The 5HTTLPR Low Versus High Activity Alleles are Associated with High Versus Low Aggressive Behaviour, But Not Suicidality James Kennedy 8:30 a.m. CNS Serotonergic Functioning, Alcohol, Genotype X by Rearing Interactions and Violence Using a Nonhuman Primate Model James Higley 9:00 a.m. Variation in Allelic Expression of Genes Associated with Aggression Larry Siever 9:30 a.m. Novel Functional Variation in the Serotonin Transporter and Tryptophan Hydroxylase Genes and Linkage to Complex Behavioral Phenotypes David Goldman 10:00 a.m. Discussion We PA Larry Siever David Goldman 58 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 59 8:00 - 10:30 AM Subregions Medial Temporal Lobe & Cognition King’s 2 Subregions in the Medial Temporal Lobe: Implications for Normal and Disordered Cognition Chair: Co-Chair: Terry Goldberg Stephan Heckers 8:00 a.m. The Hippocampus and Episodic Memory: Cognitive and Neural Mechanisms Howard Eichenbaum 8:30 a.m. Binding Processes and Structures in Working Memory and Long-Term Memory: Interaction of Hippocampal and Neocortical Areas Jaap Murre 9:00 a.m. Hippocampal Contribution to the Novel Use of Relational Information in Declarative Memory John Gabrieli 9:30 a.m. Hippocampal Dysfunction in Psychiatric Disorders Stephan Heckers 10:00 a.m. Discussion 59 We PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 60 8:00 - 10:30 AM GSK-3: A Novel Target for Severe Neuropsychiatric Diseases Kona 5 Drug Development GSK-3: A Novel Target for Improved Therapeutics for Severe Neuropsychiatric Diseases Chair: Co-Chair: We Marc Caron Husseini Manji 8:00 a.m. Involvement of an Akt/β-arrrestin2/PP2A Signaling Complex in the Actions of Dopamine Marc Caron 8:30 a.m. Targeting Glycogen Synthase Kinase-3 as a Treatment for Bipolar Disorder Todd Gould 9:00 a.m. GSK-3 as a Target of Lithium Action in Bipolar Disorder and Alzheimer’s Disease Peter Klein 9:30 a.m. Genetic Analysis of GSK-3·α and β in Conditional Knockout Mice and Stem Cells Jim Woodgett 10:00 a.m. Discussion PA 60 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 61 8:00 - 10:30 AM Screening Models for Alcoholism Medications King’s 3 Validation of Screening Models for Medications Development to Alcoholism Chair: Co-Chair: Robert Swift Raye Litten 8:00 a.m. High Throughput Pharmacological Screening for Lead Compounds at Molecular Targets of Relevance to Alcohol Dependence John Littleton 8:30 a.m. Development of Animal Models of Excessive Drinking, Protracted Abstinence, and Cue-Induced Relapse for Medications Development George Koob 9:00 a.m. Application of Functional Genomics to Animal Models of Alcoholism for Target Discovery and Validation Markus Heilig 9:30 a.m. Development and Validation of Human Laboratory Models for the Prediction of Medication Efficacy in Clinical Trials Barbara Mason 10:00 a.m. Discussion 61 We PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 62 8:00 - 10:30 AM Treating the Elderly with Antipsychotics Queen’s 4 Is it Worth the Risks? Treating the Elderly with Antipsychotics Chair: Co-Chair: We Lon Schneider Pierre Tariot 8:00 a.m. What Are the Risks? Lon Schneider 8:30 a.m. Long-Term Adverse Effects: Old and New? Dilip Jeste 9:00 a.m. What About Efficacy? Pierre Tariot 9:30 a.m. Cost-Effectiveness of Atypical Antipsychotics in the CATIE Alzheimers Disease Trial Robert Rosenheck 10:00 a.m. Discussion PA 62 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 63 8:00 - 10:30 AM Neuregulin and Schizophrenia Queen’s 5 Neuregulin and Schizophrenia: From Genetic Sequence to Pathogenic Mechanisms Chair: Daniel Weinberger 8:00 a.m. The Relevance of NRG1-erbB Signaling in Oligodendrocytes to Schizophrenia Gabriel Corfas 8:30 a.m. Neuregulin, Nicotine and Schizophrenia David Talmage 9:00 a.m. Neuregulin mRNA and Protein in Patients with Schizophrenia Cynthia Weickert 9:30 a.m. SNPing Away at NRG1 and ErbB4 Gene Expression in Schizophrenia We Amanda Law 10:00 a.m. Discussion PA 63 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 64 8:00 - 10:30 AM Sensorimotor Gating: A New Role for the CRF System Queen’s 6 Animal Models of Deficient Sensorimotor Gating: A New Role for the Corticotropin-Releasing Factor System? Chair: Co-Chair: \We Mark Geyer Vaishali Bakshi 8:00 a.m. CRF1 and CRF2 Receptor Modulation of Information Processing Victoria Risbrough 8:30 a.m. Is Dopamine to Blame for CRF-Induced Sensorimotor Gating Deficits in Rats? Ronald Hammer 9:00 a.m. Effects of Antipsychotics and Manipulations of the Serotonin System on the Corticotropin-Releasing Factor-Induced Decrease in PPI in Rats Lisa Conti 9:30 a.m. Acute and Long-Term Effects of Stress and CRF on Prepulse Inhibition Vaishali Bakshi 10:00 a.m. Discussion PA 64 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 65 2:30 - 5:00 PM Synaptic Alterations in Neuropsychiatric Disorders & Addiction King’s 1 Molecular Mechanisms of Synaptic Alterations Associated with Neuropsychiatric Disorders and Addiction Chair: Co-Chair: Lorna Role Jonathan Pollock 2:30 p.m. Synapse Assembly in the Developing Brain: The Active Role of the Adhesion Molecule SynCAM Thomas Biederer 3:00 p.m. Identification and Analysis of a Rac1 Regulator That Mediates Dendritic Pruning Peter Scheiffele 3:30 p.m. Developmental Synapse Elimination is Mediated by the Complement Cascade Ben Barres 4:00 p.m. Synapse to Nucleus Signaling During Long-term Synaptic Plasticity: A Role for the Classical Active Nuclear Import Kelsey Martin 4:30 p.m. Discussion 65 We PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 66 2:30 - 5:00 PM Tourette Syndrome: Neuropsychiatric Disorders King’s 3 Tourette Syndrome-A Window into Neurochemistry and Neuropharmacology of Many Comorbid Neuropsychiatric Disorders Chair: Co-Chair: We Dean Wong Anthony Grace 2:30 p.m. Striatal Biology and Tourette Syndrome Roger Albin 3:00 p.m. Tics and Tourette Syndrome in Children: Genetics and Public Health Impact Lawrence Scahill 3:30 p.m. Abnormalities of the Dopamine and Serotonin Systems Associated with Tourette Syndrome Dean Wong 4:00 p.m. Treatment of Tourette Syndrome and Co-Occurring Conditions John Walkup 4:30 p.m. Discussion PA 66 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 67 2:30 - 5:00 PM Advances in Neurotensin Neurobiology Queen’s 4 Drug Development Advances in Neurotensin Neurobiology: Implications for Novel Treatments for Psychosis and Drug Abuse Chair: Co-Chair: 2:30 p.m. Elliott Richelson Charles Nemeroff Viral Vector-Induced Overexpression of the NT1 Receptor in the Nucleus Accumbens: Further Evidence for Antipsychotic Effects of Increased NTergic Neurotransmission Charles Nemeroff 3:00 p.m. Neurotensin Regulation of Corticostriatal Function: Implications for Schizophrenia Ariel Deutch 3:30 p.m. The Role of Neurotensin in Estrous Cycle Regulation of Prepulse Inhibition of Acoustic Startle We Becky Kinkead PA NT69L: A Neurotensin Receptor Agonist for Treatment of Neuropsychiatric Diseases Elliott Richelson 4:00 p.m. 4:30 p.m. Discussion 67 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 68 2:30 - 5:00 PM Cortical Dopaminergic Neurotransmission & Cognition Kona 5 Cortical Dopaminergic Neurotransmission and Cognition: Neuroimaging and Physiologic Studies Chair: Co-Chair: We Robert Innis Karen Berman 2:30 p.m. Dopamine Modulation of Glutamate and GABA Responses in the Rat Prefrontal Cortex Patricio O’Donnell 3:00 p.m. The Cortical D1 Receptor: A Biomarker for Cortical Dopamine Transmission? Anissa Abi-Dargham 3:30 p.m. PET Imaging of Dopamine Metabolism and Receptors in Cortex: Relation to Cognitive Function in Parkinson’s Disease Robert Innis 4:00 p.m. Interactions of Prefrontal Function and Dopamine: Multimodal Neuroimaging of Genetic Modulation Andreas Meyer-Lindenberg 4:30 p.m. Discussion PA 68 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 69 2:30 - 5:00 PM Protein Trafficking & Therapeutic Mechanisms Queen’s 6 Protein Trafficking and Therapeutic Mechanisms for Mood Disorders Chair: Co-Chair: Mark Rasenick Maurizio Popoli 2:30 p.m. G Protein Trafficking and its Relevance to Depression and Antidepressant Therapy Mark Rasenick 3:00 p.m. Regulation of G Protein-Coupled Receptors by Endocytosis Mark von Zastrow 3:30 p.m. Modulation of AMPA Glutamate Receptor Trafficking by Antimanic Agents New Avenues for Drug Development Jing Du 4:00 p.m. Leveling Glutamate Release: A Presynaptic Path Toward Antidepressant Action Maurizio Popoli 4:30 p.m. Discussion 69 We PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 70 2:30 - 5:00 PM 5-HT6 Receptors & Neuropsychiatric Disorders King’s 2 5-HT6 Receptors: New Targets for Neuropsychiatric Disorders Chair: Co-Chair: 2:30 p.m. John Neumaier Theresa Branchek The 5-HT6 Receptor: Filled with Promise or Promises Unfilled? David Nelson 3:00 p.m. 5-HT6 Receptors in Striatum Inhibit RewardMotivated Learning John Neumaier 3:30 p.m. Selective Serotonin 5-HT6 Receptor Antagonist(s) for the Treatment of Obesity Patrizia Caldirola We 4:00 p.m. PA 4:30 p.m. A 14 Day, Dose Escalation, Double Blind, Randomized, Placebo-Controlled Study of SGS518 in Adult Patients with Schizophrenia Ann Neale Discussion 70 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 71 2:30 - 5:00 PM Stress in Addiction Relapse & Treatment Targets Queen’s 5 Stress in Addiction Relapse: Are There Viable Treatment Targets? Chair: Co-Chair: Charles O’Brien Rajita Sinha 2:30 p.m. Novel Pharmacological Treatment Targets to Address Stress-Induced Relapse: Insights from Animal Models Friedbert Weiss 3:00 p.m. The Role of Stress in Smoking Relapse: That’s So Yesterday Saul Shiffman 3:30 p.m. Lofexidine Attenuates Stress Induced Drug Craving and Arousal to Improve Stress-Induced Relapse Outcomes Rajita Sinha 4:00 p.m. Stress and Drug Cues Motivate Smoking Relapse: Are We There Neurobiological Substrates That Account for This Association? PA Raymond Niaura 4:30 p.m. Discussion 71 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 72 8:00 - 10:30 AM Animal Models to Predict Pro-Cognitive Effects King’s 1 Selecting Animal Models to Predict Pro-Cognitive Effects in Human Populations Chair: Co-Chair: Th John Csernansky Mark Geyer 8:00 a.m. Predictive Validity of Rodent Models of Learning and Memory John Csernansky 8:30 a.m. Neuropsychopharmacological Models of Attentional Dysfunction and Their Translation to the Clinic Trevor Robbins 9:00 a.m. Evaluating Sensorimotor Gating Measures in Animals as Predictors of Pro-Cognitive Effects in Humans Mark Geyer 9:30 a.m. Serotonergic Neuromodulation of Behavioral and Cognitive Functions in Humans Franz Vollenweider 10:00 a.m. Discussion PA 72 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 73 8:00 - 10:30 AM Synaptic Plasticity & Long-Term Depression King’s 2 Synaptic Plasticity: Focus on the Mechanisms and Clinical Implications of Long-Term Depression Chair: Co-Chair: Robert Malenka Mark Bear 8:00 a.m. Regulation of AMPA Receptor Function and Synaptic Plasticity Richard Huganir 8:30 a.m. Distinct Triggering and Expression Mechanisms Underlie LTD of AMPA Receptor and NMDA Receptor Synaptic Responses Robert Malenka 9:00 a.m. Long-Term Synaptic Plasticity at Excitatory and Inhibitory Synapses on Dopamine Neurons of the VTA Julie Kauer 9:30 a.m. The mGluR Theory of Fragile X Mental Retardation Mark Bear 10:00 a.m. Discussion 73 Th PA pnls-sg 2006.qxp 11/17/05 7:45 AM Page 74 8:00 - 10:30 AM Functional Neuroanatomy & Neurochemistry of Resilience Kona 5 Advances in Functional Neuroanatomy and Neurochemistry of Resilience Chair: Co-Chair: Rachel Yehuda Dennis Charney 8:00 a.m. Neural Substrates of Stress Inoculation Determined in vivo by Brain Imaging in Monkeys David Lyons 8:30 a.m. Neuroanatomic and Neuroendocrine Alterations in Trauma Survivors Associated with Coping and PTSD Risk Factors Rachel Yehuda 9:00 a.m. Levels of Emotional Awareness and Alexithymia in Traumatized Subjects with and Without PTSD: Implications for Resilience Ruth Lanius 9:30 a.m. Th The Psychobiology of Human Resilience to Stress Dennis Charney PA 10:00 a.m. Discussion 74 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 75 8:00 - 10:30 AM Emotion Recognition & Schizophrenia King’s 3 If You Prick Them, Do They not Bleed? Emotion Recognition and Schizophrenia Chair: Co-Chair: Daniel Javitt Pamela Butler 8:00 a.m. Hear No Evil: Early-Stage Auditory Processing and Emotion Recognition Deficits in Schizophrenia Daniel Javitt 8:30 a.m. See No Evil: Early-Stage Visual Processing and Emotion Recognition Deficits in Schizophrenia Pamela Butler 9:00 a.m. Fear No Evil: Top-Down and Bottom-Up Processing of Emotions in Schizophrenia Investigated with Blocked and Event-Related fMRI Ruben Gur 9:30 a.m. To Thine Own Self Be True: Consummatory vs. Appetitive Pleasure in Schizophrenia William Horan Th Discussion PA 10:00 a.m. 75 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 76 8:00 - 10:30 AM Clock Genes, Melatonin & Affective Disorders Queen’s 4 Clock Genes, Melatonin and Affective Disorders Chair: Co-Chair: Alfred Lewy William Bunney 8:00 a.m. Melatonin Receptors As Targets For Modulation Of Circadian Rhythms Margarita Dubocovich 8:30 a.m. In Winter Depression (SAD), the Sweet Spot for the 10 pg/ml Plasma Dim Light Melatonin Onset (DLMO) is Six Hours Before Mid-Sleep Alfred Lewy 9:00 a.m. The Role of Per Genes in Addiction and Depression Rainer Spanagel 9:30 a.m. The Molecular Clock as a Target in the Treatment of Bipolar Disorder Francesco Benedetti Th 10:00 a.m. Discussion PA 76 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 77 8:00 - 10:30 AM Endocannabinoid System: Target for Drug Discovery Queen’s 5 The Endocannabinoid System as Target for Drug Discovery Chair: Alexandros Makriyannis 8:00 a.m. Overview of the Endocannabinoid System, CB1 Receptor Antagonists Alexandros Makriyannis 8:30 a.m. Neuroprotection Through Direct and Indirect Activation of Cannabinoid CB1 Receptors Ben Bahr 9:00 a.m. Progress Towards the Development of a PET Radioligand for Cannabinoid CB1 Receptors Samuel Gatley 9:30 a.m. “Gone to Pot”: Emerging Pharmacological Evidence Implicating Cannabinoid Receptor Function in Cognition and Psychosis - Implications for Medications Development Deepak D’Souza 10:00 a.m. Discussion Th PA 77 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 78 8:00 - 10:30 AM Noradrenergic Focus: Attention-Deficit Disorders Queen’s 6 A Noradrenergic Focus on Attention and Attention-Deficit Disorders Chair: Co-Chair: Randy Blakely Maureen Hahn 8:00 a.m. Norepinephrine Transporters: Genetic Variants and their Impact on Transporter Function and Regulation Maureen Hahn 8:30 a.m. Molecular Control of Noradrenergic Gene Expression and the Impact of Polymorphisms on Attention Disorders Kwang-Soo Kim 9:00 a.m. Role for Norepinephrine in Attention, Learning and Memory: Insights from Knockout Mice Steven Thomas 9:30 a.m. Th Noradrenergic Pharmacotherapies in Attention Deficit Hyperactivity Disorder Thomas Spencer PA 10:00 a.m. Discussion 78 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 79 12:30 - 2:00 PM Teaching Neuropsychopharmacology Kona 5 Teaching Neuropsychopharmacology The Neglected Constituencies: Can Teaching About Psychopharmacology Change Attitudes and Practices? Fifth Annual Teaching Session 12:30 p.m. Introduction Ira Glick 12:35 p.m. Medical Students – What is Relevant and How Much to Cover? Murray Raskind 12:50 p.m. NIMH – Intramural and Extramural Psychopharmacology: Education in a Research Setting Donald Rosenstein 1:05 p.m. Primary Care Physicians & Other Mental Health Providers – Where Does Psychopharmacology Fit In? Sidney Zisook Th 1:20 p.m. Industry – The Challenge of Teaching at the Academic- PL Industry Interface Terence Ketter & Ira Glick 1:35 p.m. The Public & Media – Education in the Context of “Stigma” Among Other Issues Ellen Frank 1:45 p.m. General Discussion 79 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 80 2:30 - 5:00 PM Plastic Changes in the Addicted Brain Kona 5 Plastic Changes in the Addicted Brain: A Glimpse at the Next Generation of Pharmacotherapies Chair: Co-Chair: Th Susan Weiss Ruben Baler 2:30 p.m. Neuroadaptations in Proteins in the Postsynaptic Density and Cocaine Addiction Peter Kalivas 3:00 p.m. Role of Amygdala ERK in Incubation of Cocaine Craving Yavin Shaham 3:30 p.m. The Endogenous Brain Cannabinoid System and the Motivational Control of Reinforced Behavior Steven Goldberg 4:00 p.m. Why Are Drugs That Enter the Brain Rapidly Potentially the Most Addictive? Terry Robinson 4:30 p.m. Discussion PA 80 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 81 2:30 - 5:00 PM Neural Changes in Adolescence & Schizophrenia King’s 2 Neural Changes in Adolescence and Onset of Schizophrenia Chair: Patricio O’Donnell 2:30 p.m. Structural MRI of Typical Adolescent Brain Development Jay Giedd 3:00 p.m. Changes in Prefrontal Dopamine Function During Adolescence and in a Developmental Animal Model of Schizophrenia Patricio O’Donnell 3:30 p.m. Differential Expression in Schizophrenic Brain of a DISC1 Molecular Pathway and Association with DISC1 SNPs Barbara Lipska 4:00 p.m. Brain Development in Childhood Onset Schizophrenia and their Healthy Siblings Judith Rapoport 4:30 p.m. Discussion Th PA 81 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 82 2:30 - 5:00 PM Neuregulin 1 - ErbB4 Signaling in Schizophrenia King’s 1 Neuregulin 1 - ErbB4 Signaling in Schizophrenia Chair: Co-Chair: Steven Arnold Chang-Gyu Hahn 2:30 p.m. Neuregulin/ErbB Signaling in Schizophrenia: An Overview Cary Lai 3:00 p.m. Neuregulin 1- ErbB Signaling During Neuronal Migration in the Developing and Adult Cerebral Cortex Eva Anton 3:30 p.m. Regulation of Synaptic Plasticity by the NRG-1/ErbB Signaling Pathway: Possible Implications for Schizophrenia Andres Buonanno 4:00 p.m. ErbB4 Signaling is Altered in Schizophrenia Chang-Gyu Hahn 4:30 p.m. Discussion Th PA 82 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 83 2:30 - 5:00 PM Autism Spectrum Disorders: Neurobiology & Treatment King’s 3 Drug Development Novel Insights into the Neurobiology and Treatment of Autism Spectrum Disorders Chair: Co-Chair: Larry Young Husseini Manji 2:30 p.m. Neuropeptides and the Social Brain: The Value of Comparative Studies in Autism Research Larry Young 3:00 p.m. Molecular Mechanisms of Fragile X Syndrome Reveal Potential Therapeutic Approaches Stephen Warren 3:30 p.m. Clues From Basic Neurodevelopment For New Treatment Targets in Autism Pat Levitt 4:00 p.m. Pharmacological Treatment of Behavioral Symptoms in Autism Christopher McDougle 4:30 p.m. Discussion Th PA 83 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 84 2:30 - 5:00 PM Neural Mechanisms of Extinction Queen’s 6 Neural Mechanisms of Extinction: Translating from Rats to Humans Chair: Co-Chair: Gregory Quirk Scott Rauch 2:30 p.m. Extinction Training Initiated Shortly After Trauma May Reduce Spontaneous Recovery, Renewal and Reinstatement: Implications for Exposure-Based Psychotherapy Michael Davis 3:00 p.m. Retention of Fear Extinction in Rats Depends on Infralimbic Prefrontal Cortex Plasticity Gregory Quirk 3:30 p.m. Neural Mechanisms of Long- and Short-Term Fear Extinction in Humans Fred Helmstetter 4:00 p.m. Magnetic Resonance Imaging Studies of Extinction Retention in Human Subjects Scott Rauch 4:30 p.m. Discussion Th PA 84 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 85 2:30 - 5:00 PM Sex Differences in the Action of Opioids Queen’s 4 Sex Differences in the Action of Opioids Chair: Co-Chair: Jon-Kar Zubieta Anne Murphy 2:30 p.m. Opioid Drugs: Where Sex Makes a Difference Christopher Evans 3:00 p.m. Sex Differences in Opiate Pharmacological Effects in Humans James Zacny 3:30 p.m. Sex Differences in the Antihyperalgesic Actions of Morphine Anne Murphy 4:00 p.m. Sex Differences and Gonadal Steroid Influences on Mu-Opioid Receptor Neurotransmission in Humans Jon-Kar Zubieta 4:30 p.m. Discussion Th PA 85 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 86 2:30 - 5:00 PM Whole Genome Association Studies Queen’s 5 Whole Genome Association Studies: New Promise for Psychiatric Genetics Chair: Co-Chair: John Kelsoe Elliot Gershon 2:30 p.m. Linkage and Association Findings in Bipolar Disorder and Schizophrenia Elliot Gershon 3:00 p.m. Whole Genome Association: Technologies and Strategies for Application to Psychiatric Illness John Kelsoe 3:30 p.m. Dissecting Neuropsychiatric Traits Through WholeGenome Association Analysis Dietrich Stephan 4:00 p.m. Analysis Techiniques for Whole Genome Association Studies David Cutler 4:30 p.m. Discussion Th PA 86 pnls-sg 2006.qxp 11/17/05 7:45 AM Page 87 POSTERS pnls-sg 2006.qxp 11/17/05 7:45 AM Page 88 Posters 2006.qxp 11/17/05 7:46 AM Page 89 Poster Session I—Monday 1. Statistical and Pharmacoeconomic Issues for Annual Alzheimer Screening J W. Ashford*, Jared R. Tinklenberg, Helena C. Kraemer, Javaid Sheikh, Ruth O’Hara, Joy Taylor, Jerome A. Yesavage 2. Alterations in Brain CRF and SRIF in a Transgenic Mouse Model of Alzheimer’s Disease (Tg2576) Following Treatment with a High Fat Diet Garth Bissette*, Katherine Ketchum, Jennifer Horgan 3. Participation in Alzheimer’s Disease Clinical Trials: A Focus on African American Caregivers Warachal E. Faison* 4. Guanfacine Augmentation of Donepezil In The Treatment of Alzheimer’s Disease Joseph I. Friedman*, Hillel Grossman, Maureen Fusco, Kristin Swedish, Jessica Stern, Mary Sano, Kenneth Davis 5. Anxiolytic Actions of an Estrogen Receptor Beta Agonist in Aged Female Rats Robert J. Handa*, T. John Wu, Trent D. Lund 6. The Neuroanatomical Patterns Associated With Neuropsychiatric Symptoms In Older Adults With And Without Cognitive Impairment: An MRI Study Helen Lavretsky*, Ling Zheng, Michael Weiner, Dan Mungas, Bruce Reed, Joel Kramer, William Jagust, Helena Chui, Wendy J. Mack 7. Deficit in the GABAergic Neuroactive Steroid Allopregnanolone in Alzheimer’s Dementia and Relevance to Neuropathological Disease Stage: Investigations in Temporal Cortex Christine E. Marx*, David C. Steffens, Dan G. Blazer, Marian I. Butterfield, Christine Hulette, John Ervin, Jeffrey A. Lieberman, Lawrence J. Shampine 89 Posters 2006.qxp 11/17/05 7:46 AM Page 90 Poster Session I—Monday 8. The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Ameliorates the Cognitive Dysfunction in the AmyloidTreated Mice: Involvement of Dopaminergic Systems Yukihiro Noda*, Yuan Zhou, Dayong Wang, Akihiro Mouri, Hiroyuki Mizoguchi, Toshitaka Nabeshima 9. Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer’s Disease Are Reversed by Inhibition of Gamma Secretase Menelas N. Pangalos*, J S. Jacobsen, Thomas A. Comery, Chi-Cheng Wu, Jeffrey M. Redwine, Robert Arias, Robert Martone, Susan Aschmies, Kevin P. Atchinson, John H. Morrison, Karen Marquis, Bloom E. Floyd, Peter H. Reinhart 10. Frontal, Parietal, and Callosal Degradation in Aging: A Quantitative DTI Fiber Tracking Study Adolf Pfefferbaum*, Edith V. Sullivan 11. Subjective Cognitive Impairment: The Pre-Mild Cognitive Impairment Stage of Brain Degeneration: Longitudinal Outcome After a Mean of 7 Years Follow-Up Barry Reisberg*, Steven Ferris, Mony J. De Leon, Carol Torossian, Sridhar Kadiyala, Wei Zhu 12. Effect of Catechol-O-Methyl Transferase val 158 Met Polymorphism on Information Processing in the Prefrontal Cortex during Working Memory in the Elderly Fabio Sambataro*, Elesha Kingshott, Saumitra Das, Bhaskar S. Kolachana, Christie Russo, Allan F. Mirsky, Terry Goldberg, Michael F. Egan, Andreas Meyer-Lindenberg, Joseph H. Callicott, Daniel R. Weinberger, Venkata S. Mattay 13. Serotonin Modulates Longevity and Global Gene Expression in the Mammalian Brain Etienne Sibille*, Jing Su, Samuel Leman, A.M. Le Guisquet, Rene Hen, Catherine Belzung 14. PET Studies of Cholinergic Modulation of Serotonin in Alzheimer Disease (AD) Gwenn Smith*, Elisse Kramer, Carol Hermann, Yilong Ma, Margaret Kirshner, David Eidelberg, Bruce Pollock 90 Posters 2006.qxp 11/17/05 7:46 AM Page 91 Poster Session I—Monday 15. Stress History and Breast Cancer Recurrence Oxana Palesh, Lisa D. Butler, Cheryl Koopman, Helena C. Kraemer, Robert Carlson, David Spiegel* 16. Benefits of Memantine/Donepezil Treatment on Behavior in Moderate to Severe AD Using Factor-Analytically Derived Subscales Pierre Tariot*, Jeffrey Cummings, Jason Olin 17. Is Translational Research Monkey Business: The Journey of a Novel AMPAKINE (CX 717) from Primate to a Human Phase 1B Study with a Cognitive Impairment Model Gary Tollefson*, Hank Mansbach, Samuel Deadwyler 18. Cholinergic Receptor Systems in Cocaine-Addicted Subjects: Alterations in Regional Cerebral Blood Flow Bryon Adinoff*, Mark J. Williams, Susan E. Best, Tanya Zielinski, Thomas S. Harris, Erica R. Schreffler, Michael D. Devous 19. C-fos Activation Correlates with Cocaine Preference in Adolescent Rats Susan L. Andersen*, Lucinda Kussmaul, Lee Napierata 20. A Primer on Multivariate Methods for Pharmacoepidemiology: Cocaine Dependence Illustration James C. Anthony* 21. Extinction-Induced Up-Regulation in AMPA Receptors Attenuates Sensitization to Cocaine and D2 Receptor Stimulation Ryan K. Bachtell*, Lisa Monteggia, Rachael L. Neve, David W. Self 22. Comparative Molecular Field Analyses of Amphetamine, Cocaine, and Antidepressant Recognition at Serotonin Transporter Mutants Reveals Contributions of Transmembrane Helix III to Ligand Binding Eric L. Barker*, Crystal C. Walline 23. Effects of Standard Dopaminergics and Comparison of D3 and D2 Receptor Ligands on Choice Between Concurrently Available Cocaine and Food in Rats Andrew C. Barrett*, S S. Negus, Amy H. Newman, Peter Grundt, S B. Caine 91 Posters 2006.qxp 11/17/05 7:46 AM Page 92 Poster Session I—Monday 24. Behavioral And Neurochemical Effects Of Chronic Exposure To D2 Agonist Treatment In Monkeys Jack Bergman*, Walter Tornatzky, Frank Tarazi 25. Neurotensin System Genes and Susceptibility to Cocaine-induced Psychosis Elisabeth B. Binder*, Yilang Tang, Charles B. Nemeroff, Joseph F. Cubells 26. Relationships Between State Policies and the Availability of Services for HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs Lawrence S. Brown*, Steven Kritz, John Rotrosen, Sherryl Baker, Jim Robinson 27. N-3 Polyunsaturated Fatty Acids Decrease Feelings Of Anger In A Population Of Substance Abusers Laure Buydens*, Marc Branchey, Alec Roy 28. Reduced Cocaine Self-Administration in Muscarinic M5 Acetylcholine Receptor-Deficient Mice Morgane Thomsen, David P. Woldbye, Gitta Woertwein, Anders FinkJensen, Juergen Wess, Simon B. Caine* 29. Decreased CNS Serotonin Turnover, Early-life Stress, and Initial Response to Ethanol are Predictors of Ethanol Consumption in Adolescent Rhesus Macaques Scott A. Chen*, Christina S. Barr, Melanie L. Schwandt, Stephen G. Lindell, Daniel Hommer, Susan Shoaf, Stephen J. Suomi, Markku Linnoila, J D. Higley 30. Pain and Opioid Addiction: Complex Relationship Wilson M. Compton*, Yonette Thomas, Kevin P. Conway, Marc D. Brodsky 31. Attenuation of Ethanol and Sucrose-Seeking and Intake Following Chronic Acamprosate or Naltrexone Treatment Cristine Czachowski*, Michael DeLory 92 Posters 2006.qxp 11/17/05 7:46 AM Page 93 Poster Session I—Monday 32. Insulin And Amphetamine: What’s Up With Dat? Lynette Daws*, W A. Owens, Adrian K. France, Rajkumar Sevak, Aurelio Galli, Charles P. France 33. Stress, Alcohol, and Fluvoxamine: Composing the Score for a Dissonant ConSERT Nicole L. Baganz Strode, Jaclyn L. Munn, Janel M. Boyce-Rustay, Andrew Holmes, Lynette Daws* 34. An Association Study of Adenosine Receptor Gene Polymorphisms and Acute Responses to Caffeine in Light- or Non-Caffeine Users Harriet De Wit*, Emma Childs, Christa Hohoff, Jurgen Deckert 35. Dual Diagnosis and Drinking Behaviors in an Outpatient Treatment Seeking Sample of Adolescents with Alcohol Use Disorders Deborah Deas*, Himanshu Upadhyaya, Suzanne Thomas 36. A Double Blind Placebo Controlled Trial of Bupropion Added to Nicotine Patch and Cognitive Behavioral Therapy in Smokers with Current or Past Unipolar Depressive Disorder A. Eden Evins*, Jonathan E. Alpert, Joel Pava, Timothy J. Petersen, Amy H. Farabaugh, Maurizio Fava 37. Genomic Screen for Loci Associated with Marijuana, Stimulant and Drug Dependence in Mission Indians: Relation to Body Mass Index Cindy L. Ehlers*, Kirk C. Wilhelmsen 38. The Effects of Exogenous Progesterone on Cocaine Self-Administration in Women Suzette M. Evans*, Richard W. Foltin 39. Differences in the Dopamine System Correspond to Individual Differences in Pavlovian Conditioned Approach Behavior Shelly B. Flagel*, Tracy Simmons, Stanley J. Watson, Terry Robinson, Huda Akil 93 Posters 2006.qxp 11/17/05 7:46 AM Page 94 Poster Session I—Monday 40. Differential Roles for the Basolateral Amygdala and Medial Prefrontal Cortex in Extinction and Cue-Induced Reinstatement of Food-Seeking Behavior Ryan J. McLaughlin, Stan B. Floresco* 41. The Role of the Basolateral Amygdala in Consolidation of StimulusReward Associations and Subsequent Conditioned Cued-Reinstatement of Cocaine Seeking Rita A. Fuchs*, Matthew W. Feltenstein, Ronald E. See 42. Regulation of Alcohol-Heightened Aggression by Dorsal Raphe and Prefrontal Cortical 5-HT1B Receptors: Evidence from Microinjection and Microdialysis Studies in Mice Sara P. Faccidomo, Makoto Bannai, Jeremy Maggin, Klaus A. Miczek* 43. Evidence of White Matter Pathology in First-Episode Manic Adolescents with Bipolar Disorder: A Diffusion Tensor Imaging Study Caleb M. Adler*, John Adams, Melissa P. DelBello, Scott K. Holland, Vince Schmithorst, Ari Levine, Kelly Jarvis, Stephen M. Strakowski 44. Quetiapine Efficacy in Bipolar Adolescents with Depressive Symptoms Drew H. Barzman, Caleb M. Adler*, Melissa P. DelBello, Kevin E. Stanford, Robert A. Kowatch, Stephen M. Strakowski 45. Measurement of Brain Betabolites in Type 2 Diabetes and Depression Using Proton Magnetic Resonance Spectroscopy Olu Ajilore*, E Haroon, C Darwin, N Binesh, A Thomas, S Kumaran, J Miller, A Kumar 46. Escitalopram Responders Have Higher Quality of Life Scores Than Placebo Responders George Alexopoulos*, Andrew Korotzer, Anjana Bose, Khalil Saikali 47. Gender Differences in Sleep Regulation in Depressed Adults and Healthy Controls Roseanne Armitage*, Robert Hoffmann 94 Posters 2006.qxp 11/17/05 7:46 AM Page 95 Poster Session I—Monday 48. Glutamate Transporter Gene (SLC1A1) Associated with Obsessive Compulsive Disorder Paul D. Arnold*, Tricia Sicard, Eliza Burroughs, Margaret A. Richter, James L. Kennedy 49. A Study of Long-Acting, Injectable Risperidone in Frequently Relapsing Bipolar Disorder: Preliminary Findings Earle Bain*, Georges Gharabawi, Julie Locklear, Ibrahim Turkoz, Deborah Yurgelun-Todd 50. Association of an Ancient CRH Gene Haplotype with HPA Axis Activity in Rhesus Macaques Christina S. Barr*, Timothy K. Newman, Stephen J. Suomi, Robert Lipsky, David Goldman, J D. Higley 51. Regional Cerebral Metabolism and Anxiety Symptoms in Bipolar Depression: Effects of Levothyroxine Michael Bauer*, Edythe D. London, Steven M. Berman, Natalie Rasgon, Mark A. Mandelkern, Bradley Voytek, Peter C. Whybrow 52. Duloxetine: Meta-Analyses of Suicidal Behaviors and Thoughts in Clinical Trials for Major Depressive Disorder Nayan V. Acharya, Amy S. Rosen, John P. Polzer, Deborah N. DSouza, David G. Perahia, Patrizia A. Cavazzoni, Charles M. Beasley*, Ross J. Baldessarini 53. Generalized Anxiety and Pain: Associations and Implications Katja Beesdo*, Frank Jacobi, Hans-Ulrich Wittchen 54. Brain Regional α-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive Compulsive Disorder Alexandre Berney, Marco Leyton, Paul Gravel, Pedro Rosa-Neto, C Todorov, Debbie Sookman, Gilbert Pinard, Pierre Blier, Mirko Diksic, Chawki Benkelfat* 55. Antidepressant Drug Combination from Treatment Initiation to Improve Therapeutic Response in Major Depression Richard Bergeron*, Philippe Tremblay, Herbert E. Ward, Chantal Hebert, Pierre Blier 95 Posters 2006.qxp 11/17/05 7:46 AM Page 96 Poster Session I—Monday 56. Subjective Evaluation of the Long-Term Cognitive Effects of Electroconvulsive Therapy Robert M. Berman*, Joan Prudic, Mark Olfson, Harold A. Sackeim 57. Pharmacological Dissection of the Effect of Risperidone on SSRI-Induced Changes of Norepinephrine Neuronal Firing Pierre Blier*, Eliyahu Dremencov, Mostafa El Mansari 58. Activity of a Selective Galanin-3 Receptor (GAL3) Antagonist In Acute and Chronic Behavioral Models of Anxiety and Depression Thomas P. Blackburn, Chad J. Swanson, Toni D. Wolinsky, Michael J. Konkel, Mary M. Walker, Margaret Durkin, Roman P. Artymyshyn, Kelli E. Smith, Kenneth A. Jones, Douglas A. Craig, Christophe P. Gerald, Theresa A. Branchek* 59. Attention Bias to Threat in Bipolar Children With or Without Comorbid Anxiety Disorders Melissa A. Brotman*, Brendan A. Rich, Mariana Schmajuk, Christopher S. Monk, Karin Mogg, Brendan P. Bradley, Daniel S. Pine, Ellen Leibenluft 60. Post-Retrieval Propranolol Weakens Longstanding Traumatic Memories Alain Brunet*, Scott P. Orr, Jacques Tremblay, Karim Nader, Roger K. Pitman 61. Serotonin Transporter Polymorphism Association with Neuroticism and Depression: A Controversy Evaluated Margit Burmeister*, Srijan Sen, Debashis Ghosh 62. A Pilot Controlled Trial of Bupropion vs. Es-Citalopram in Generalized Anxiety Disorder (GAD) Alexander Bystritsky*, Lauren Kerwin, Samuel Eiduson, Tanya Vapnik 63. Serotonin Transporter Binding in Unmedicated Bipolar Disorder Subjects using [Carbon-11] DASB and Positron Emission Tomography Dara M. Cannon*, Masahiro Ichise, Stephem Fromm, Allison C. Nugent, Denise Rollis, Shilpa K. Gandhi, Wayne C. Drevets 96 Posters 2006.qxp 11/17/05 7:46 AM Page 97 Poster Session I—Monday 64. Depressive-Like Effects of the Kappa-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats William A. Carlezon*, Cecile Beguin, Jennifer A. DiNieri, Michael H. Baumann, Michele R. Richards, Mark S. Todtenkopf, Richard B. Rothman, Zhongze Ma, David Y. Lee, Bruce M. Cohen 65. Prefrontal Neurometabolite Changes Following Lamotrigine Treatment in Adolescents with Bipolar Depression Kiki Chang*, Kim Gallelli, Meghan Howe, Kirti Saxena, Christopher Wagner, Daniel Spielman, Allan Reiss 66. The ERK Pathway in Left Anterior Cingulate Cortex Modulates Locomotive and Hedonic Activities Guang Chen*, Thomas Creson, YanLei Hao, Sharon Engel, Husseini K. Manji 67. Glucocorticoid Modulation of TPH2 Protein in Raphe Nuclei and Frontal Cortical 5-HTP Levels in C57/Bl6 Mice Janet Clark*, Lee-Yuh Pai, Rachel Conley, Rosemarie B. Flick, Ildiko Szalayova, Eva Mezey, Peter H. Hutson, Ariel Deutch, Susan P. Rohrer, Osvaldo Flores 68. Ontogeny of Individual Differences in Emotional Reactivity Sarah Clinton*, John D. Stead, Sue Miller, Delia Vasquez, Stanley Watson, Huda Akil 69. A Pilot Study of the Effect of Omega-3 Fatty Acids on Heart Rate Variability in Anxiety Disorders Kathryn M. Connor*, Wei Zhang, Victoria Payne, Lana Watkins, Jonathan Davidson 70. Adjunctive Eszopiclone and Fluoxetine in Major Depressive Disorder and Insomnia: Effects on Sleep and Depression Mark Corrigan*, W V. McCall, Maurizio Fava, Robert Rubens, Thomas Wessel, Judy Caron, David Amato, Thomas Roth 71. Engraftment of a Monoaminergic Cell Line within Affective Neural Circuitry Miles G. Cunningham*, Rachael Donalds, William Carlezon, Susan Anderson, Lee Napierata, Kwang-Soo Kim, Dong-Wook Kim 97 Posters 2006.qxp 11/17/05 7:46 AM Page 98 Poster Session I—Monday 72. Cardiovascular Effects of Duloxetine: Preclinical and Clinical Findings Michael J. Detke*, Smriti Iyengar, Judith W. Henck, Frank Bymaster, John T. Callaghan, Mary Pat Knadler, Joachim F. Wernicke, Michael E. Thase 73. A Psychosocial Approach to Depression in Parkinson’s Disease Roseanne D. Dobkin*, Lesley A. Allen, Matthew Menza 74. Serotonin Attenuates Mating-Induced Glutamate Activity in the Medial Preoptic Area: Implications for Impaired Libido Resulting from SSRIs Juan M. Dominguez*, Mario Gil, Jessica H. Brann, Elaine M. Hull 75. Association of the Functional -1019C/G 5-HT1A Polymorphism with Decreased Prefrontal Cortex Activation Measured with 3T fMRI in Panic Disorder Katharina E. Domschke*, Miriam Braun, Patricia Ohrmann, Thomas Suslow, Harald Kugel, Jochen Bauer, Christa Hohoff, Anette Kersting, Almut Engelien, Volker Arolt, Walter Heindel, Juergen Deckert 76. Membrane Localization of the G protein Gsα is Altered in Post-Mortem Brain of Depressed Suicide Victims: Possible Disruption of Plasma Membrane Rafts Robert Donati*, Justin Brown, Xinguo Ren, Yogesh Dwivedi, Robert Conley, Ghanshyam Pandey, Mark M. Rasenick 77. Lithium Normalizes Dendritic Localization of Val66met Polymorphism of Brain-Derived Neurotrophic Factor (BDNFmet): Therapeutic Implications Jing Du*, Kastuji Suzuki, Guhan Nagappan, Yun Wang, Bai Lu, Husseini Manji 78. Serotonin Transporter Activity Modulates 5-HT1B-Induced Alterations in Prepulse Inhibition and Locomotion: Implications for Obsessive Compulsive Disorder and Panic Disorder Stephanie C. Dulawa*, Kerri A. Holick, Mark S. Ansorge, Rene Hen, Jay A. Gingrich 79. Underdiagnosis of Psychotic Symptoms in Patients with Bipolar Mania David L. Dunner*, Carla M. Canuso, Cynthia A. Bossie, Young Zhu 98 Posters 2006.qxp 11/17/05 7:46 AM Page 99 Poster Session I—Monday 80. Olanzapine/Fluoxetine Combination Versus Lamotrigine in the Long-Term Treatment of Bipolar I Depression Eileen Brown, David Dunner*, David Adams, Elisabeth Degenhardt, Mauricio Tohen, Douglas Williamson, John Houston 81. A Comparison of ETRANK, MMRM and LOCF Analyses of Eighteen Placebo-Controlled Venlafaxine Clinical Trials for the Treatment of Major Depressive Disorder Richard Entsuah*, David V. Sheehan, Michael E. Thase, Ying Zhang 82. Children of Depressed Mothers in an Urban Primary Care Population Adriana Feder*, Min Tang, Virginia Warner, Angelique Alonso, Eva Barranco, Daniel J. Pilowsky, Helena Verdeli, Priya Wickramaratne, Myrna M. Weissman 83. The DID Anhedonia Rating Scale: Results of the First Validation Study James M. Ferguson*, Ken Evans, Terry Sills, Heather McDonald 84. Passive Avoidance Learning and Response Reversal During Tryptophan Depletion Elizabeth Finger*, Abigail Marsh, Niveen Kamel, Karina Peschardt, Meena Vythilingam, Daniel Pine, James Blair 85. Cognitive Performance in Bipolar Disorder: A Processing Efficiency Account David E. Fleck*, Paula K. Shear, Robert A. Kowatch, Stephen M. Strakowski 86. A Pilot Trial of Escitalopram for Depression in Perimenopausal Women Marlene P. Freeman*, Rebecca Hill, Barbara H. Brumbach, Alan J. Gelenberg 87. Modafinil in the Treatment of Bipolar Depression: A Placebo-Controlled Trial Mark A. Frye* 88. Epigenetic Determinants of GAD1/GAD67 (2q31.1) Expression in Human Prefrontal Cortex Hsien-Sung Huang, Schahram Akbarian* 99 Posters 2006.qxp 11/17/05 7:46 AM Page 100 Poster Session I—Monday 89. Asenapine, a Novel Psychotherapeutic Agent with Efficacy in Positive and Negative Symptoms During Acute Episodes of Schizophrenia: A Randomized, Placebo- and Risperidone-Controlled Trial Steven G. Potkin, Miriam Cohen, Ross A. Baker, Anil S. Jina, Steven Nettler, Larry Alphs*, John Panagides 90. Training for Assessment of Negative Symptoms of Schizophrenia Across Languages and Cultures Utilizing the Negative Symptom Assessment Scale Larry Alphs*, David G. Daniel, Dawn Velligan, John Bartko, John Panagides, John Davis 91. Insulin And Igf-1 Reverse Mitochondrial, Energy Metabolism, Proteasome, And Neuronal Plasticity Gene Decreases Of Schizophrenia In An MrnaBased Screen For Antischizophrenia Agents C. A. Altar*, Rachel A. Hunt, Jurata W. Jurata, Eric Derby, Paul Gallagher, Andrew Lemire, Pascal Laeng 92. A Double-Blind Randomized Trial of a Single Dose of Placebo, Haloperidol, and Risperidone in Healthy Volunteers Celso Arango*, Juan Francisco Artaloytia, Adrienne Lahti, Javier Sanz, Ana Pascual, Pedro Cubero, David Prieto, Tomas Palomo 93. Corticotropin-Releasing Factor (CRF) Impairs Sensorimotor Gating In The Sprague-Dawley Rat: Reversal By Clozapine And Raclopride Isabel C. Arrillaga-Romany*, Ronald P. Hammer 94. Type of Symptom Remission and Treatment Outcomes in the Long-Term Treatment of Patients with Schizophrenia Haya Ascher-Svanum*, Baojin Zhu, Douglas Faries, Bruce J. Kinon, John M. Kane 95. PCP-Disrupted Social Interaction Paradigm in Rats: Differential Effects of Typical and Atypical Antipsychotics: Putative Role of α2-Adrenoceptor Antagonism? Louisa Douglas, Nicole Golembo, Hilde Duytschaever, Barbara Biemans, Sahana Nayak, David Ashton* 100 Posters 2006.qxp 11/17/05 7:46 AM Page 101 Poster Session I—Monday 96. Predictors of Patient Satisfaction with Medication in Patients with Schizophrenia A G. Awad*, Andrew Greenspan, Colette Kosik-Gonzalez, Young Zhu, Cynthia A. Bossie, Amir H. Kalali, Georges M. Gharabawi, Michael Davidson 97. Targeting the Cystine-Glutamate Antiporter to Attenuate the Behavioral and Neurochemical Effects in the Phencyclidine Rodent Model of Schizophrenia David Baker*, Aric Madayag, Eric Haschke, Rostian Akpor-Mensah 98. NRG-1 Protein Levels in Patients with Schizophrenia, Bipolar Disorder and Major Depression Senda Beltaifa*, Maree J. Webster, Cynthia Shannon Weickert 99. Alterations of Postsynaptic AMPA Receptor Trafficking in the Anterior Cingulate Cortex in Elderly Schizophrenics Monica Beneyto*, Arjune K. Rama, Vahram Haroutunian, James H. Meador-Woodruff 100. AVE1625, a Cannabinoid CB1 Antagonist, as a Co-Treatment for Schizophrenia: Improvement in Cognitive Function and Reduction of Antipsychotic-Side Effects in Animal Models Beth Borowsky*, Rachel Stevens, Black Mark, Senyah Yaw, Nancy Rogacki, Odessa Giardino, Odile Piot-Grosjean, Jeremy Pratt, Robert Lenox 101. Divergence of PPI Deficits and P50 Suppression Deficits in Schizophrenia Patients Point to Two Dissociable Endophenotypes: Implications for Genetic Analyses in the COGS Project David Braff*, Gregory Light, Kristin Cadenhead, Joyce Sprock, Neal Swerdlow 102. Elevated Prenatal Homocysteine as a Risk Factor for Schizophrenia Alan S. Brown*, Teodoro Bottiglieri, Catherine A. Schaefer, Charles P. Quesenberry, Liyan Liu, Michaeline Bresnahan, Ezra S. Susser 101 Posters 2006.qxp 11/17/05 7:46 AM Page 102 Poster Session I—Monday 103. Evidence That a DTNBP1 Risk Haplotype is Associated with Negative Symptoms and Cognitive Dysfunction in Patients with Schizophrenia Katherine E. Burdick*, Pamela DeRosse, Birgit Funke, Todd Lencz, Philip R. Szeszko, John M. Kane, Raju Kucherlapati, Anil K. Malhotra 104. Hypometabolic Medial-Frontal Effects of Chronic Intermitent PCP Exposure in Rats Assessed with High Resolution Magic Angle Spin 11.7T Proton Magnetic Resonance Spectroscopy Juan R. Bustillo*, Nora Perrone-Bizzozero, Rodrigo Paz, Gayle Griffith, Matthew Galloway 105. The Eyes Don’t Have It: Face Processing in Schizophrenia Pamela D. Butler*, Arielle Tambini, Yovel Galit, Maria Jalbrzikowski, Rachel Ziwich, Nancy Kanwisher, Uriel Heresco, Shlomo Bentin, Daniel C. Javitt 106. Neurocognitive Deficits in Prodromal and First Episode Schizophrenia are Stable and Predictive of Social Functioning Kristin Cadenhead*, Angela Eastvold, David Braff, Robert Heaton 107. The Consortium on the Genetics of Schizophrenia (COGS): Recruitment and Assessment Methods in a Multi-Site Collaboration ME Calkins*, DJ Dobie, KS Cadenhead, A Olincy, DL Braff 108. Prefrontal Cortex Inefficiency During Working Memory in Unaffected Siblings of Patients with Schizophrenia: A Replication Joseph H. Callicott*, Steven Sust, Hao-Yang Tan, Venkata S. Mattay, Joshua Buckholtz, Michael F. Egan, Daniel R. Weinberger 109. Promoter Specific Alterations of BDNF mRNA in Frontal Cortex in Patients with Schizophrenia Hope L. Cassano*, Thomas M. Hyde, Amy Deep-Soboslay, Joel E. Kleinman, Cynthia Shannon Weickert 110. Trait vs. State Markers for Schizophrenia: the Case of Visual Motion Processing Yue Chen*, L Cinnamon Bidwell, Philip Holzman 102 Posters 2006.qxp 11/17/05 7:46 AM Page 103 Poster Session I—Monday 111. Identification and Characterization of Behavioral Plasticity Genes in Drosophila William Cho*, Fred Wolf, Ulrike Heberlein 112. Confirmation of the Association of 10 Genes with Atypical Anti-Psychotic Treatment Emergent Weight Gain in a Cohort with an Obesity Phenotype Sandra Close Kirkwood*, Richard D. Hockett, Nitai D. Mukhopadhyay, Dong-Jing Fu, R. Arlen Price, John Blanchard, Dennis Ballinger, David R. Cox, Alan Breier 113. Patient-Reported and Clinician-Rated Depressive Symptoms in the Treatment of Schizophrenia Robert Conley*, Haya Ascher-Svanum, Baojin Zhu, Douglas Faries, Bruce Kinon 114. Investigating Cortical Inhibition as a Potential Mechanism of Atypicality in the Antipsychotic Clozapine Using Transcranial Magnetic Stimulation Zafiris J. Daskalakis*, Sarah I. Fountain, Robert Chen 115. Null Mutation of the Alpha-2A Adrenoceptor in Mice Fails to Alter Visuospatial Attention or the Performance Enhancing Effects of Guanfacine J David Jentsch* 116. Ziprasidone Dosing Study in Pediatric Patients with Bipolar Disorder, Schizophrenia, or Schizoaffective Disorder Mark Versavel, Melissa P. DelBello*, Kathleen Ice, Robert Kowatch, David Keller, Jeffrey Miceli 117. Brain Structural and Functional Deficits in Subjects at High Genetic Risk for Schizophrenia Lynn E. DeLisi*, Kamila Szulc, Hilary C. Bertisch, Kyle Brown, Magda Majcher, Sarah Branch, David Mack, Raj Sangoi, Matthew Hoptman, Craig Branch 118. Population Pharmacokinetic Analysis of Drug-Drug Interactions Among Risperidone, Bupropion, and Sertraline in CF-1 Mice Lindsay DeVane*, Jun-Sheng Wang, Brian Gibson, Jennifer Donovan, John Markowitz, Haojie Zhu 103 Posters 2006.qxp 11/17/05 7:46 AM Page 104 Poster Session I—Monday 119. A Data-Driven Approach for Understanding the Stages of Schizophrenia John Docherty*, Stephen Rodriguez, Colette Kosik-Gonzalez, Cyndi Bossie, Georges Gharabawi, Sam Siris 120. Deficits in PFC Activity in Schizophrenia Patients During the Maintenance and Response Selection Phases of Working Memory Naomi R. Driesen*, Hoi-Chung Leung, R. T. Constable, Pawel Skudlarski, Patricia S. Goldman-Rakic, John H. Krystal 121. Reduced Hospitalisation in Patients with Schizophrenia Initiated with Risperidone Long-Acting Injection (LAI): 3 Month Follow-Up from the eSTAR Database Dieter Naber, Harry Hustig, Dominique Rosillon, Lennart Wetterberg, Sue Caleo, Mike Ingham, Bo Eriksson*, An Jacobs 122. Natural Prepulse Inhibition Deficits in Brattleboro Rats Respond to Valproic Acid Augmention of Clozapine: Further Support for the Predictive Validity of this Animal Model David Feifel*, Paul Shilling, Gilia Melendez 123. Corollary Discharge Failure in Schizophrenia is Related to Severity of Auditory Hallucinations: fMRI Evidence Judith M. Ford*, May Gray, Gary Glover, William O. Faustman, Susan L. Whitfield, Daniel H. Mathalon 124. Mice Deficient for an Immediate Early Gene Show a Heightened Response to Environmental Stressors Consistent with a Schizophrenia Phenotype Amelia Gallitano-Mendel*, David Wozniak, Maureen Boyle, Louis Muglia, Jeffrey Milbrandt 125. A Pilot Study Assessing the Effects of Dar-0100 (A Dopamine D1 Full Agonist) on Regional Brain Activity and Task-Specific Activation in Patients with Schizophrenia Mark S. George*, Ziad Nahas, Berry Anderson, F. A. Kozel, Qiwen Mu, Chris Molnar, Michael Knable, Prabhavathi Fernandes, David Nichols, Richard Mailman 104 Posters 2006.qxp 11/17/05 7:46 AM Page 105 Poster Session I—Monday 126. Neuropsychological Deficits in Non-Smokers with Schizophrenia: Effects of a Nicotinic Antagonist Tony P. George*, Kristi A. Sacco 127. Exploring the Evidence for a Relationship Between Symptomatic Remission and Improvement in Functioning in Patients With Schizophrenia Georges Gharabawi*, Cyndi Bossie, Steve Rodriguez, Ibrahim Turkoz, George Simpson 128. Appraising Neurocognitive Endophenotypes for Schizophrenia David C. Glahn*, Laura Almasy, Jaun Manuel Peralta, Gary M. Burk, Jose Estrada, Naxhielli Meyenberg, Mariana Pereira Castro, Humberto Nicolini, Henriette Raventos, Michael A. Escamilla 129. Placebo-Controlled, Add-On Trial of CX516 (Ampakine) in Schizophrenia Donald C. Goff*, J. S. Lamberti, Alexander Miller, Jayendra K. Patel, Theo Manschreck, Oliver Freudenreich, Michael F. Green, Andrew Leon, Steven Johnson 130. The Trajectory is The Story: Cortical Gray Matter Changes During Adolescence In Childhood Onset Schizophrenia Evolve Into The Adult Pattern By Age 25 Nitin Gogtay*, Deanna Greenstein, Jay Giedd, Liv Clasen, Alexandra Sporn, Marge Lenane, Jason Lerch, Alan Evans, Judith Rapoport 131. Reelin (RELN) Promoter Hypermethylation In Gaba Neurons In Schizophrenia Dennis R. Grayson*, Ying Chen, Rajiv P. Sharma, Alessandro Guidotti, Erminio Costa 132. The Consortium on the Genetics of Schizophrenia (COGS): Preliminary Heritability Analyses of Endophenotypic Measures for Schizophrenia Tiffany A. Greenwood*, David L. Braff, Neal R. Swerdlow, Michael F. Green, Keith Nuechterlein, Allen D. Radant, William S. Stone, Ann Olincy, Raquel Gur, Nicholas J. Schork 133. Convergence of Cognitive Improvement with Development of Clinical Remission in Schizophrenia Philip D. Harvey*, Antony Loebel, Christopher R. Bowie 105 Posters 2006.qxp 11/17/05 7:46 AM Page 106 Poster Session I—Monday 134. Cognitive and Functional Improvement with Long Term Treatment with Long-acting Risperidone Philip D. Harvey*, Gahan Pandina, Robert M. Bilder, Steven Rodriguez, Ibo Turkoz, Georges Gharabawai 135. Cognitive Coping and Illusion of Control Can Both Modulate Hypothalamic-Pituitary-Adrenal Response to Pharmacological Activation James L. Abelson*, Samir Khan, Israel Liberzon, Hedieh Briggs, Elizabeth A. Young 136. Mifepristone for the Prevention of Olanzapine-Induced Weight Gain in Rats Katherine L. Beebe*, Thaddeus Block, Charles DeBattista, Christine Blasey, Alan F. Schatzberg 137. Ovarian Steroids Suppress the Apoptosis-Inducing Protein JNK1 in the Dorsal Raphe Region of Macaques Cynthia L. Bethea*, Lisa J. Smith 138. Effects of Left Prefrontal rTMS on Laboratory, Neuropathic and PostOperative Pain Jeffrey J. Borckardt*, A. R. Smith, Mitchell Weinstein, Scott T. Reeves, Stephen Gibert, Audrey Barry, F. A. Kozel, Mark S. George 139. Indiplon Dose-Response Analyses For Objective and Subjective Measures of Sleep Brian Corrigan*, Raymond Miller, Phillip B. Chappell, Robert Farber, Danielle Ouellet, Dimitri E. Grigoriadis 140. Plasma L-Tryptophan Depletion and Loading Time-Course and Side-Effect Comparison of 50 and 100g Formulations Donald M. Dougherty*, D.M. Marsh, C.W. Mathias, M.A. Addicott, A.A. Jagar, C.J. Morgan, A.A-B. Badawy 141. Prevalence of Intact Decision-Making Capacity for Research Among People with Schizophrenia Using Two Standards Laura B. Dunn*, Barton W. Palmer, Dilip V. Jeste 106 Posters 2006.qxp 11/17/05 7:46 AM Page 107 Poster Session I—Monday 142. Methamphetamine-Induced Dopamine Complex Formation: A Role For Reactive Oxygen Species and Dopamine Receptors Anthony J. Baucum, Kamisha L. Johnson-Davis, Glen A. Cook, Glen R. Hanson, Annette Fleckenstein* 143. Response to Methylphenidate in Symptoms of Most Concern to Parents of Preschool Children with Developmental Disorders Jaswinder K. Ghuman*, Rick Cruz, Ron Wright, Harinder S. Ghuman, Alan Gelenberg 144. Inhibition of Dopamine Transporter Activity by Cannabinoids Andrea Giuffrida*, David A. Price, Lynette C. Daws, W A. Owens, Georgianna G. Gould, Alan Frazer, Alexander Seillier, James L. Roberts 145. Differences in Cognitive Function and Acute Sedative Effects of Risperidone and Quetiapine Among Individuals with Stable Bipolar I Disorder Howard A. Hassman*, Steven J. Glass, Luella Engelhart, Lian Mao, Stephen Rodriguez, Georges Gharabawi, Robert Bilder, David G. Krefetz, Maria Pinho, Harbans Lal 146. Family Study of Binge Eating Disorder James I. Hudson*, Justine K. Lalonde, Cynthia M. Bulik, Scott J. Crow, Susan L. McElroy, Nan M. Laird, Ming T. Tsuang, B. T. Walsh, Norman R. Rosenthal, Harrison G. Pope 147. Duloxetine: Summary of Time to Response in a Preclinical and a Clinical Model of Neuropathic Pain Smriti Iyengar*, Yili L. Pritchett, Jerry A. Hall, Amy S. Chappell, Joachim F. Wernicke, David J. Goldstein, Rosa M. Simmons, Michael J. Detke, Shuyi Shen, Deborah N. DSouza, Michael J. Robinson 148. Seizure Risk Among Patients Participating in Psychopharmacology Clinical Trials Arif Khan*, Kenneth Alper, Kelly Schwartz, Russell Kolts, Walter Brown 107 Posters 2006.qxp 11/17/05 7:46 AM Page 108 Poster Session I—Monday 149. Early Life Stress Impairs Memory and Produces Hippocampal Degeneration in Adult Rats Therese A. Kosten*, David A. Karanian, Colin N. Haile, Thomas R. Kosten, Jeansok J. Kim, Priscilla Kehoe, Ben A. Bahr 150. The Role Of Postsynaptic Alpha-2 Noradrenergic Receptors In The Modulation Of Cortical Activity Antonieta Lavin*, Glenn D. Andrews 151. Effects of Childhood Trauma and Acute Lorazepam on Fear-Related Cortico-Limbic Brain Reactivity: A Pilot Pharmacological fMRI Study Royce Lee*, Kin L. Phan, Michael Angstadt, Daniel A. Fitzgerald, Allan Klock, Michael S. McCloskey, Emil F. Coccaro 152. Trophic Factors and Adrenergic Function Dona Lee Wong*, T.C. Tai, David C. Wong-Faull, Robert Claycomb 153. Functional Outcomes in Adults with Attention-Deficit/Hyperactivity Disorder Following Treatment with Atomoxetine vs. Placebo Louise Levine*, Roy N. Tamura, Douglas K. Kelsey, Darryle D. Schoepp, Albert J. Allen 154. Abnormal Glutamate and Dopamine Receptor Function in the Striatum of Alpha-Synuclein Overexpressing Mice Michael S. Levine*, Nan-Ping Wu, Carlos Cepeda, Eliezer Masliah 155. Asenapine Preferentially Increases Dopamine (DA) and Acetylcholine (ACh) Efflux in Rat Medial Prefrontal Cortex (mPFC) and Hippocampus (HIP) Zhu Li*, Mohammed Shahid, Herbert Y. Meltzer 156. Topiramate for the Treatment of Moderate to Severe Binge Eating Disorder Associated with Obesity A Double-Blind, Placebo-Controlled Study Susan McElroy*, James I. Hudson, Julie A. Capece, Karen Beyers, Alan C. Fisher, Norman R. Rosenthal 157. Effect of Risperidone and Olanzapine on Measures Associated with the Insulin Resistance Syndrome Herbert Y. Meltzer*, Yuejin Chen, Karu Jayathilake 108 Posters 2006.qxp 11/17/05 7:46 AM Page 109 Poster Session I—Monday 158. Multiple Novel Polymorphisms in the Rhesus Macaque DRD4 5’ UTR are Associated with Impulsive Behavior Timothy K. Newman*, Christina S. Barr, Rachel E. Holston, Nicole Y. Davis, Stephen J. Suomi, David Goldman, J D. Higley 159. Metabolic Profile in Children and Adolescents with Disruptive Behavior Disorders Treated with Risperidone Magali Reyes, Gahan J. Pandina*, Ilse Augustyns, Robert L. Findling 160. The Association of Fatigue with Poor Virologic Response in Patients Receiving Interferon-Alpha Plus Ribavirin for the Treatment of Hepatitis C Charles L. Raison*, Carmine M. Pariante, Lucile Capuron, Bin Chen, Bobbi J. Woolwine, Paul M. Plotsky, Ira M. Jacobson, Andrew H. Miller 161. Randomized, Double-Blind, Placebo-Controlled Study of Armodafinil for the Treatment of Excessive Sleepiness Associated With Chronic Shift Work Sleep Disorder Thomas Roth*, Charles A. Czeisler, James K. Walsh, Keith A. Wesnes, Michael Williams, Gwendolyn E. Niebler, Sanjay Arora 162. A Complementary Strategy to Approach the Genetics of Schizophrenia Dan Rujescu*, Ina Giegling, Annette Hartmann, Just Genius, Christoph Mulert, Ulrich Hegerl, Heinz Grunze, Pierandrea Mulia, Claire Birell, Andreas Ruppert, Thomas Meitinger, Martin Keck, Frauke Ohl, Manfred Ackenheil, Hans-Jurgen Moller 163. Serotonin Transporter Polymorphism Influences the Prolactin Response to Tryptophan and Stress Cynthia M. Kuhn, Kishore Gadde, Saul M. Schanberg*, Douglas A. Marchuk, Ilene C. Siegler, Richard S. Surwit, Redford B. Williams 164. 5-HT6 Receptor Stimulation Induces Neuroprotective Properties In Vitro and In Vivo Lee E. Schechter*, Margaret Zaleska, Mark Bowlby, Danni Liu, Shi Liang, John A. Harvey, Al Robichaud, Ron Bernotas, Derek Cole, Kevin Pong 109 Posters 2006.qxp 11/17/05 7:46 AM Page 110 Poster Session I—Monday 165. Onset of Antidepressant Action and Acute Efficacy and Safety of Duloxetine Versus Escitalopram and Placebo in the Treatment of Major Depressive Disorder AA Nierenberg*, JH Greist, CH Mallinckrodt, A Prakash, JG Watkin, A Sambunaris, GD Tollefson, MM Wohlreich 110 Posters 2006.qxp 11/17/05 7:46 AM Page 111 Poster Session II—Tuesday 1. Diffusion Tensor Imaging in Cocaine Dependence: Evidence for Reduced Myelin in the Anterior Corpus Callosum F. Gerard Moeller*, Khader M. Hassan, Joel L. Steinberg, Ignacio Valdes, Larry Kramer, Ponnada A. Narayana, Alan C. Swann 2. Effects of Self-Administered and Passive Cocaine Infusions on Dopamine, Norepinephrine and Corticosterone Concentrations in the Medial Prefrontal Cortex Nicholas E. Goeders*, Gennady N. Smagin, Marie F. Lanfranco, Patricia K. Seitz, Mary L. Thomas, Kathryn A. Cunningham, Vitaly S. Palamarchouk 3. Decreased Corticolimbic Responset To Monetary Reward in Cocaine Addiction: Association with Motivation and Self-Control Rita Z. Goldstein*, Dardo Tomasi, Nelly Alia-Klein, Lisa A. Cottone, Lei Zhang, Thomas Maloney, Frank Telang, Elisabeth C. Caparelli, James M. Swanson, Nora D. Volkow 4. Interactions Between Nalbuphine, Mood and Hypothalamic-Pituitary-Axis (HPA) Hormones Nathalie V. Goletiani*, Jack H. Mendelson, Michelle B. Sholar, Arthur J. Siegel, Alicja Skupny, Nancy K. Mello 5. Aripiprazole Decreases Alcohol Drinking in Syrian Golden Hamsters David T. Chau, Alan I. Green* 6. Time-Dependent Dissociation Between Accumbal and Amygdalar Mediation of Cue-Induced Cocaine Seeking Jeffrey W. Grimm*, Meghan Manaois, Dan Osincup, Amber Fyall, Barbara Wells 7. Effects of Baclofen on Cocaine Self-Administration: Opioid-Dependent and Non-Opioid Dependent Volunteers Margaret Haney*, Carl Hart, Richard W. Foltin 111 Posters 2006.qxp 11/17/05 7:46 AM Page 112 Poster Session II—Tuesday 8. Modafinil Attenuates Disruptions in Performance and Mood During Simulated Night Shift Work Carl L. Hart*, Margaret Haney, Suzanne K. Vosburg, Sandra D. Comer, Erik Gunderson, Richard W. Foltin 9. Psychiataric Symptoms Among Outpatients in an Open-Label Trial of Risperidone for Methamphetamine Dependence Craig Jaffe*, Andrew J. Saxon, Charles W. Meredith 10. Gender Differences in Substance Use by Healthcare Professionals in a State Sample George A. Kenna*, Robert M. Swift 11. Intravenous Nicotine Self-Administration in C57BL6/J Mice Paul J. Kenny*, Athina Markou 12. Behavioral Pharmacology and Pharmacokinetics of Cocaine Analogs in Rhesus Monkeys Heather L. Kimmel*, S S. Negus, Sarah B. Ewing, John R. Votaw, Mark M. Goodman, F I. Carroll, Nancy K. Mello, Leonard L. Howell 13. Synergistic Interactions Between “Club Drugs”: Gamma-Hydroxybutyrate and N-Methyl-D-Aspartate Antagonists Wouter Koek*, Mandar Khanal, Charles P. France 14. Six-Month Trial of Bupropion with Contingency Management for Cocaine Dependence Thomas R. Kosten*, James Poling, Alison Oliveto, Kishor Gonsai, Mehmet Sofuoglu, Gerardo Gonzalez, Bridget Martell 15. Naltrexone and Fluoxetine for Relapse to Heroin Dependence in St. Petersburg, Russia Evgeny M. Krupitsky*, Edwin E. Zvartau, Elena V. Verbitskaya, Charles P. O’Brien, George E. Woody 16. Are Adolescent Rats Addiction-Prone and Hyperresponsive to Stimulants Because They Are Hypodopaminergic? Quentin D. Walker, Joseph M. Caster, Lauren Gerlach, Sarah Parylak, Sarah Morris, Cynthia M. Kuhn* 112 Posters 2006.qxp 11/17/05 7:46 AM Page 113 Poster Session II—Tuesday 17. Ethanol Does Not Affect Discriminative Stimulus Effects of Nicotine in Rats Bernard Le Foll*, Steven R. Goldberg 18. Blockade of D2/D3 Dopamine Receptors Selectively Impairs Reversal Learning, but not New Learning, in Monkeys Performing a Visual Discrimination Task Buyean Lee*, Edythe D. London, J. D. Jentsch 19. Endocrine Challenge of the HPA Axis Differentially Modulates Plasma Deoxycortisosterone and Pregnenolone Levels in Cynomolgus Monkeys A. Leslie Morrow*, Patrizia Porcu, Laura S. Rogers, Kathleen A. Grant 20. The Effect of Dopamine Precursor Depletion on Alcohol SelfAdministration in Men: Individual Differences Sean P. Barrett, Robert O. Pihl, Chawki Benkelfat, Caroline Brunelle, Simon N. Young, Marco Leyton* 21. Examining White Matter Abnormalities in Cocaine Dependence with T2 Relaxography Kelvin O. Lim*, Bryon A. Mueller, Sheila M. Specker, Jeffrey R. Wozniak 22. Variation in the rhNPY Promoter Is Associated with Differences in CSF Levels of NPY and Alcohol Consumption Christina S. Barr, Stephen G. Lindell*, Stephen J. Suomi, David Goldman, J D. Higley 23. The Effects of CRH-1 Antagonist Antalarmin on Cocaine SelfAdministration and Discrimination Nancy K. Mello*, S S. Negus, Kenner C. Rice, Jack H. Mendelson 113 Posters 2006.qxp 11/17/05 7:46 AM Page 114 Poster Session II—Tuesday 24. The Effects of ‘Binge’ Cigarette Smoking on Hypothalamic-PituitaryAdrenal Axis Hormones and Mood in Men Jack H. Mendelson*, Nathalie V. Goletiani, Michelle B. Sholar, Arthur J. Siegel, Nancy K. Mello 25. Dose-Dependent Effects of Topiramate on Alcohol Cue Reactivity and the Subjective Effects of Drinking: Preliminary Data Robert Miranda*, Peter Monti, Robert Swift, James MacKillop, Jennifer Tidey, Chad Gwaltney, Damaris Rohsenow 26. 5-HT1B Receptors in Nucleus Accumbens Efferents Can Increase both Rewarding and Aversive Effects of Cocaine John F. Neumaier*, Sabiha Barot 27. Factor Analysis of the Y-BOCS in Autistic Disorder Evdokia Anagnostou*, William Chaplin, Dryden Watner, Jeremy Silverman, Eric Hollander 28. Decreased Cortisol Response to the Trier Social Stress Test in Healthy Adults with Significant Childhood Adversity Linda L. Carpenter*, Audrey R. Tyrka, John P. Carvalho, Lauren Wier, Gerard G. Gagne, Andrea F. Mello, Marcelo F. Mello, George M. Anderson, Lawrence H. Price 29. Variable Foraging Demand (VFD) Exposure of Primate Maternal-Infant Dyads and Impaired Insulin Action in Juvenile Offspring Jeremy D. Coplan*, Daniel Kaufman, Igor Shorman, Eric L. Smith, Michael J. Owens, Charles B. Nemeroff, Leonard A. Rosenblum, John G. Kral, MaryAnn Banerji 30. Early Postnatal Brain Structure and Development in Humans: Sexual Dimorphism and Cerebral Asymmetry are Present at Birth John Gilmore*, Christopher Looney, Yethiraja Vesta, J. K. Smith, Weili Lin, Jeffery A. Lieberman, Guido Gerig 114 Posters 2006.qxp 11/17/05 7:46 AM Page 115 Poster Session II—Tuesday 31. Oxytocin Increases Social Cognition in Autism Eric Hollander*, William Chaplin, Ann Phillips, Jennifer Sumner, Latha Soorya, Evdokia Anagnostou, Stacey Wasserman 32. Individual Differences in Physiological Regulation and Early Development of African-American Infants Living in Poverty Suma Jacob*, Kate Keenan 33. Developmental Regulation of NCAM in Human Frontal Cortex L. F. Jarskog*, Patricia F. Maness, Karissa L. Gable, Anthony-Samuel LaMantia, Jeffrey A. Lieberman, John H. Gilmore 34. Gender-Specific Longitudinal Changes in Cortical Thickness in Children and Adolescents Rhoshel Lenroot*, Philip Shaw, Kristin Taylor, Dede Greenstein, Liv Clasen, Alan Evans, Jay N. Giedd 35. Behavioral and Electrophysiological Characterization of the Role of MeCP2 in the Brain Lisa Monteggia*, Erika Nelson, Terry Gemelli, Olivier Berton, Linda Perrotti, Rudolf Jaenisch, Ege Kavalali 36. A Prospective, Open-Label Study of Atomoxetine for ADHD Symptoms Associated with Higher-Functioning Pervasive Developmental Disorders David J. Posey*, Ryan E. Wiegand, Wilkerson Jennifer, Melissa Maynard, Kimberly A. Stigler, Christopher J. McDougle 37. Relationship Between Behavior and Neurochemical Changes in Rhesus Macaques During a Separation Paradigm Simona Spinelli*, Melanie Schwandt, Kristine Erickson, Stephen Lindell, Jay Schulkin, Philip Gold, Stephen J. Suomi, J. D. Higley 38. Dysfunction of Critical Regulators of Serotonergic Signaling Confers Autism Susceptibility James S. Sutcliffe*, Ryan J. Delahanty, Harish C. Prasad, Qiao Han, Lan Jiang, Randy D. Blakely 115 Posters 2006.qxp 11/17/05 7:46 AM Page 116 Poster Session II—Tuesday 39. Cortical and Amygdala Overgrowth in Autism Associated With 5-HTTLPR Thomas H. Wassink*, Heather Cody, Matthew Mosconi, Eric Epping, Joseph Piven 40. The Sp4 Transcription Factor Gene is Critical for Postnatal Development of Dentate Gyrus in Mice and Associated with Bipolar Disorder in Humans Xianjin Zhou*, John Kelsoe, Mark A. Geyer 41. Genetic Correlates of Cortico-Limbic Activity and Connectivity in Major Depression Amit Anand*, Yu Li, Yang Wang, Sujuan Gao, Jingwei Wu, Mark J. Lowe, Thomas Talavage, John I. Nurnberger, David Goldman, Jill Murrell 42. Comparison of the Effects of Tolcapone and Entacapone on Cognition and fMRI in Normal Volunteers Jose A. Apud*, Venkata Mattay, Jingshan Chen, Kolachana S. Bhaskar, Joseph H. Callicott, Guilna Alce, Jennifer Iudicello, Natkai Akbar, Michael F. Egan, Terry E. Goldberg, Daniel R. Weinberger 43. Altered Serotonin Transporter Binding After Recovery from Anorexia Nervosa Using PET and [11C]McN5652 Ursula F. Bailer*, Guido F. Frank, Shannan E. Henry, Julie C. Price, Carolyn C. Meltzer, Angela Wagner, Claire W. McCohana, Chester A. Mathis, Walter H. Kaye 44. CBT vs Sertraline in OCD: Effects on Brain Regional Serotonin Synthesis Index Igor Sibon, Marco Leyton, Paul Gravel, Debbie Sookman, Gilbert Pinard, Mirko Diksic, Chawki Benkelfat* 45. The Neural Correlates of Social Decision-Making: An Event-Related fMRI Study Joshua W. Buckholtz*, Qiang Chen, Steven Sust, Emily M. Drabant, Beth A. Verchinski, Giuseppe Blasi, Fabio Sambataro, Venkata S. Mattay, Daniel R. Weinberger, Joseph H. Callicott 116 Posters 2006.qxp 11/17/05 7:46 AM Page 117 Poster Session II—Tuesday 46. Role of Medial Prefrontal Cortex in Intention Deficit in Schizophrenia Margaret A. Cato*, Bruce A. Crosson, Eric L. Granholm, Gregory G. Brown 47. Amygdala Hyperactivity to Angry Faces in Patients with Intermittent Explosive Disorder Emil F. Coccaro*, Michael S. McCloskey, Daniel A. Fitzgerald, K. Luan Phan 48. Prefrontal Neurochemical Abnormalities in Adolescent Bipolar Disorder Melissa P. DelBello*, Kim Cecil, Cal Adler, Stephen M. Strakowski 49. Low Frequency Oscillations of Oxy-Hemoglobin in Brain: A NearInfrared-Spectroscopic Feasibility Study Adriana Di Martino*, PaoloEmilio Barbano, Michael Milham, Christopher Hyde, F. Xavier Castellanos 50. Neural Activation During Encoding of Emotional Faces in Pediatric Bipolar Disorder Daniel P. Dickstein*, Brendan A. Rich, Roxann Roberson-Nay, Deborah T. Vinton, Lisa H. Berghorst, Daniel S. Pine, Ellen Leibenluft 51. Altered Dorsal or Ventral Prefrontal Morphology May Differentiate Risk for Schizophrenia or Bipolar Disorder: Preliminary Evidence from in vivo MRI studies Vaibhav A. Diwadkar*, Boris Birmaher, Jeffrey J. Nutche, Diana Dworakowski, David Axelson, David Brent, Debra M. Montrose, Matcheri S. Keshavan 52. Emotional Numbing in PTSD: fMRI Neuroimaging of Reward Circuitry Igor Elman*, Blaise Frederick, Dan Ariely, Steven Dunlap, John Rodolico, David Penetar, Nina Mazar, Jeannette Cohan, Roger Pitman, Scott Lukas 117 Posters 2006.qxp 11/17/05 7:46 AM Page 118 Poster Session II—Tuesday 53. Influence of Low and High Dose Hydrocortisone Infusion on Hemodynamic Response in Amygdala While Viewing Emotional Faces Kristine Erickson*, Maura L. Furey, Jay Schulkin, Suzanne E. Wood, Linda Mah, Allison C. Nugent, Wayne C. Drevets 54. Schematic Faces Evoke Exaggerated Regional Activation Within the Amygdala in Social Anxiety Disorder Karleyton Evans*, Christopher I. Wright, Michelle M. Wedig, Mark H. Pollack, Scott L. Rauch 55. Medial Prefrontal Cortical Maturation: An fMRI Study of Interference Processing in Healthy Children Kate D. Fitzgerald*, Hannah F. Chua, Robert C. Welsh, Stephan F. Taylor 56. Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Guido K. Frank*, Ursula F. Bailer, Wayne C. Drevets, Carolyn C. Meltzer, Julie C. Price, Walter H. Kaye 57. PET Imaging of the Serotonin 2a Receptor (5-HT2a) and Sertonin Transporter (SERT) in Personality Disordered Subjects with Impulsive Aggressivity WG Frankle*, PS Talbot, Y Huang, L Iskander, M Goodman, AS New, D-R Hwang, A Abi-Dargham, M Laruelle, LJ Siever 58. Subcortical Asymmetries in Bipolar and Attention Deficit/Hyperactivity Disorders Jean A. Frazier*, Janis L. Breeze, Nikos Makris, Martha R. Herbert, David N. Kennedy, Steven M. Hodge, Megan E. Dieterich, Joseph Biederman, Verne S. Caviness 59. Increased GABAergic Activity Modulates MR-Visible Glutamate and Glutamine: Studies with High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HR-MAS 1H-MRS) Matthew P. Galloway*, Navid Seraji-Bozorgzad, Kerry L. Murphy, Shonagh K. O’Leary Moore, Kristen M. Haubenreich, George M. McKelvey, Aliaksei Pustavoitau, John H. Hannigan, Harold M. Marsh 118 Posters 2006.qxp 11/17/05 7:46 AM Page 119 Poster Session II—Tuesday 60. Computational Anatomy to Assess Growth Pattern of Early Brain Development in Healthy and Disease Populations Guido Gerig*, John H. Gilmore, Matthieu Jomier, Sarang Joshi, Joseph Piven 61. Altered Pain Processing in Veterans with Posttraumatic Stress Disorder Elbert Geuze*, Anja Jochims, Christian Schmahl, Herman Westenberg, Eric Vermetten 62. Frontal Dopamine D2 Receptor Binding in Neuroleptic-Naive FirstEpisode Schizophrenic Patients Correlates with Positive Psychotic Symptoms and Predicts Treatment Outcome Birte Y. Glenthoj*, Hans Rasmussen, Torben Mackeprang, Claus Svarer, William Baare, Lars Pindborg, Lars Friberg, Ralf Hemmingsen, Charlotte Videbaek 63. White Matter Integrity in Kleptomania: A Pilot Study Jon Grant*, Stephen Correia, Thea Brennan-Krohn 64. Prevention of Relapse in MDD: An Investigation of the Neural Basis of Self-Regulation of Emotion Merida M. Grant*, Steven D. Hollon, Richard C. Shelton, Elizabeth Stringer 65. What Is the “Therapeutic Window” of Risperidone Long-Acting Injectable (RLAI)? A Meta-Analysis of Published and Unpublished Data Gerhard Grunder*, Erik Mannaert, Dean F. Wong, Rossella Medori 66. MAOA Polymorphism Affects BOLD Responses During Behavioral and Emotional Regulation Mary Heitzeg*, Zucker A. Robert, Elzbieta Sliwerska, Margit Burmeister, Jon-Kar Zubieta 119 Posters 2006.qxp 11/17/05 7:46 AM Page 120 Poster Session II—Tuesday 67. Brain Glycine Increases Detected During Oral Glycine Supplementation with TE-Averaged Proton Spectroscopy Marc J. Kaufman*, Andrew P. Prescot, Dost Ongur, A. Eden Evins, Tanya Barros, Julie Covell, Liqun Wang, John Brown, Maurizio Fava, Perry F. Renshaw 68. DTI of Cerebellar and Basal Ganglia Pathways in OCD Yijun Liu*, Wayne K. Goodman 69. The Old Drug Scopolamine Offers New Promise as a Potent Antidepressant Agent: A Randomized, Placebo-Controlled Clinical Trial Maura L. Furey*, Wayne C. Drevets 70. Genetic Analysis of Dorsal Raphe Tph2 Expression: Potential Interaction with Antidepressant Responsive Gene Kf1 (Rnf103) Steven J. Garlow*, Ericka Boone, Wei Li 71. Genetic Analysis of Dorsal Raphe 5-HT1A, SERT and Glucocorticoid Receptor Expression: Potential Shared Genetic Regulation Ericka Boone, Wei Li, Steven J. Garlow* 72. Glucocorticoid Receptor Transgenic Mice as Models for Depression Peter Gass*, Sabine Chourbaji, Stephanie Ridder, Rainer Hellweg, Alexandre Urani, Christiane Zacher, Wolfgang Schmid, Mathias Zink, Heide Hortnagl, Herta Flor, Gunther Schutz, Fritz A. Henn 73. Integration of Emotion-Laden and Working Memory-Related Information in the Prefrontal Cortex Aaron L. Goldman*, Lukas Pezawas, Gang Chen, Andreas MeyerLindenberg, Terry E. Goldberg, Ziad S. Saad, Venkata S. Mattay, Daniel R. Weinberger 74. Neural Correlates of Anxiety in Serotonin 1A Receptor-Deficient Mice Joshua A. Gordon*, Clay O. Lacefield, Clifford G. Kentros, Rene Hen 120 Posters 2006.qxp 11/17/05 7:46 AM Page 121 Poster Session II—Tuesday 75. Mouse Strain Differences in Single Dose Lithium Attenuation of Amphetamine Hyperactivity Todd D. Gould*, Alyssa M. Picchini, Kelley C. O’Donnell, Robert J. Schloesser, Husseini K. Manji 76. Prevalence of Metabolic Syndrome in Partial Responders to Selective Serotonin Reuptake Inhibitors with Major Depressive Disorder Tracy L. Greer*, Madhukar H. Trivedi, Timothy S. Church, Bruce D. Grannemann, Daniel I. Galper, Prabha Sunderajan 77. Surinabant, a New CB1 Receptor Antagonist, Displays Efficacy in Animal Models of Attention Deficit/Hyperactivity Disorder Caroline Louis, Jean-Paul Terranova, Michel Decobert, Jean-Charles Bizot, Dominique Francon, Craig Karson, Richard Alonso, Caroline Cohen, Guy Griebel* 78. The Dexamethasone/CRF Test in Men with Major Depression: Role of Childhood Trauma Christine Heim*, Tanja Mletzko, David Purselle, Dominique L. Musselman, Charles B. Nemeroff 79. Regulation of 5-HT1A Receptor Function in Inducible BDNF Knock-Out Mice Following Administration of Fluoxetine or Corticosterone Julie G. Hensler*, Lisa M. Monteggia 80. Demonstration on PET of a Widespread Deficiency in Serotonin Transporter Binding in Bipolar Depression Maria A. Oquendo, Ramin S. Hastings, Yung-yu Huang, Norman Simpson, R Todd Ogden, Ronald L. Van Heertum, J John Mann*, Ramin V. Parsey 81. Anxiolytic-Like Effects of a DNA Enzyme Targeting the CorticotropinReleasing Factor 2(a) Receptor (CRF2(a)) in the Rat Lateral Septum Steve A. Nanda, Ned H. Kalin*, Dimitri E. Grigoriadis, Patrick H. Roseboom 121 Posters 2006.qxp 11/17/05 7:46 AM Page 122 Poster Session II—Tuesday 82. A Randomized Placebo-Controlled Trial of Risperidone Augmentation for Patients with Difficult-to-Treat Unipolar, Nonpsychotic Major Depression G I. Keitner*, P T. Ninan, C E. Ryan, S Garlow, D A. Solomon, C B. Nemeroff, M B. Keller 83. Placebo-Controlled Trial of Venlafaxine ER in Prevention of Recurrence in Patients with Recurrent Unipolar Major Depression Martin B. Keller*, Bing Yan, Saeed Ahmed, Erika Parker-Zavod, Ron Pedersen 84. Rapid Cycling Differentially Exacerbates Bipolar II Compared to Bipolar I Disorder: Implications for Adjunctive Antidepressant Therapy Terence A. Ketter*, Joseph Calabrese, Charles Bowden, Lauren Marangell, Laszlo Gyulai, Andrew Nierenberg, Stephen Wisniewski, Gary Sachs 85. The REVAMP Medication Algorithm for Chronic Depression: Preliminary Results James H. Kocsis*, Martin B. Keller, Daniel N. Klein, Philip T. Ninan, Alan F. Schatzberg, Michael E. Thase, Madhukar H. Trivedi, Steven Wisniewski, Alan J. Gelenberg 86. Olanzapine in the Treatment of Acute Mania in Adolescents with Bipolar I Disorder: A 3-Week Randomized Double-Blind Placebo-Controlled Study Mauricio Tohen, Ludmila Kryzhanovskaya, Gabrielle Carlson, Melissa DelBello, Janet Wozniak, Robert Kowatch*, Karen Wagner, Robert Findling, Daniel Lin, Carol Robertson-Plouch, Wen Xu, Xiaohong Huang, Ralf Dittman, Joe Biederman 87. Paroxetine-Induced Increase in LDL Cholesterol Levels Jean-Michel Le Melledo*, Kevin Mailo, Maria Castillo Abadia, Lucas Gil, Nathalie Lara, Stephen Newman, Glen Baker, Stephen Archer, Mickael Van Ameringen 88. Reduced Brain Docosahexaenoic Acid Content After a Single Reproductive Cycle in Female Rats Maintained on a Diet Deficient in n-3 Polyunsaturated Fatty Acids Beth Levant*, Jeffery D. Radel, Susan E. Carlson 122 Posters 2006.qxp 11/17/05 7:46 AM Page 123 Poster Session II—Tuesday 89. Pooled Analysis of Response and Remission Rates with Venlafaxine ER in Social Anxiety Disorder Michael Liebowitz*, Jonathan R. Davidson, Carlos Blanco, Raj Tummala, Qin Jiang 90. Randomized Controlled Trial of the Cognitive Side Effects of Magnetic Seizure Therapy and Electroconvulsive Shock Sarah H. Lisanby*, Tammy D. Moscrip, Bruce Luber, Matthew Truesdale, Niko Reyes, Louis Trotman, Herbert S. Terrace 91. The Familial Aggregation Anxiety Disorders Ascertained from the Community versus Clinics Nancy C. Low*, Lihong Cui, Kathleen R. Merikangas 92. Increased Neurogenesis in CREB-Deficient Mice is Associated with Antidepressant-Like Behavior Jessica E. Malberg*, Alana C. C. Conti, Anita J. Bescholt, Irwin Lucki, Julie A. Blendy 93. Lithium Increases Gray Matter in the Prefrontal and Subgenual Prefrontal Cortices in Treatment Responsive Bipolar Disorder Patients Gregory J. Moore, Bernadette M. Cortese, Debra A. Glitz, Caroline Zajac-Benitez, Jorge A. Quiroz, Thomas W. Uhde, Wayne C. Drevets, Husseini Manji* 94. Vagus Nerve Stimulation for the Treatment of Rapid Cycling Bipolar Disorder Lauren Marangell*, Trisha Suppes, Holly Zboyan, Grace Fischer, James Martinez, Diane Snow, Suresh Sureddi 95. A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose, Trial of Augmentation with OROS Methylphenidate in Treatment Resistant Depression Prakash S. Masand*, Ashwin A. Patkar, Kathleen Peindl, Christa Hooper-Wood, Patrick E. Ciccone, Daniel Blazer 123 Posters 2006.qxp 11/17/05 7:46 AM Page 124 Poster Session II—Tuesday 96. A Genome-by-Genome Interaction Linkage Scan of Bipolar Disorder Melvin McInnis*, Peter Zandi, Anjene Addington, Carl Langefeld, John Nurnberger, Bill Byerley, Elliot Gershon, John Kelsoe, John Rice, Bill Scheftner, Bill Coryell, Wade Berrettini, Francis McMahon 97. Behavioral and Anatomical Interactions Between Dopamine and Corticotropin-Releasing Factor (CRF) Edward G. Meloni*, Lyle P. Gerety, Allison T. Knoll, Bruce M. Cohen, William A. Carlezon 98. Amyloid PET Imaging with Pittsburgh Compound-B in Late Life Depression with Cognitive Impairment Carolyn C. Meltzer*, Meryl A. Butters, William E. Klunk, Chester A. Mathis, Julie C. Price, Brian J. Lopresti, Scott K. Ziolko, Jessica A. Hoge, Charles F. Reynolds, Steven T. DeKosky 99. Familial Patterns of Comorbidity of Migraine and Affective Disorders Kathleen R. Merikangas*, Nancy C. Low, Lihong Cui 100. Emergence of Anhedonia in Laboratory Rats During Continuous Subordination Stress: Relevance to Antidepressants and Stimulant Abuse Klaus A. Miczek*, Herbert E. Covington, Artur K. Kieres, Jasmine J. Yap, Ella M. Nikulina 101. The Anxiolytic Opipramol Affects Calcium Signalling via Sigma Receptors Walter E. Muller*, Bettina Henke, Kristina Treiber 102. Antidepressant Prescribing Trends Pre and Post-Black Box Warning: A Review of the Medicaid Database Meera Narasimhan*, Richard Rech, Richard Harding 103. Cognitive Function in Patients with Resistant Depression: Effects of Antidepressant Monotherapy and Risperidone Augmentation Philip D. Harvey, Robert Bilder, Georges M. Gharabawi, Carla M. Canuso, Gahan J. Pandina, Ibrahim Turkoz, Charles Nemeroff* 124 Posters 2006.qxp 11/17/05 7:46 AM Page 125 Poster Session II—Tuesday 104. Alterations of Cortico-Limbic Responsiveness to Emotional Valenced Stimuli in Alpha2CDel322-325 Carriers with Depression and Controls Alexander Neumeister*, Wayne C. Drevets, David Luckenbaugh, David Goldman, Inna Belfer, Peter Herscovitch, Dennis S. Charney 105. Fluoxetine and Triiodothyronine Reduce 5-HT1A and 5-HT1B Receptor Activites and mRNA Levels in Male but Not in Female Rats Michael E. Newman*, Ronen Segman, Tsuri Lifschytz, Galit Shalom, Tanya Golzer, Eitan Gur, Bernard Lerer 106. Sleep EEG Response to Metyrapone May be a Measure of Hypothalamic CRF Activity: A Study of Women with and Without Posttraumatic Stress Disorder Thomas Neylan*, Christian Otte, Rachel Yehuda, Charles Marmar 107. CSF 5-HIAA, Suicide Intent and Hopelessness in the Prediction of Suicide in High Risk Suicide Attempters Peter Nordstrom*, Jussi Jokinen, Mats Samuelsson, Anna-Lena Nordstrom, Marie Asberg 108. Association of the Down-Regulation of the Norepinephrine Transporter in Rat Brain with the Persistent Behavioral Effects Observed Following Repeated Treatment with Desipramine James M. O’Donnell*, Alicia M. Crissman, Zaorui Zhao 109. Transmission of Mood Disorders to the Offspring of Parents with Bipolar Disorder and Major Depressive Disorder Maria A. Oquendo*, Boris Birmaher, Adrienne Tin, Jamie Zelazny, Barbara H. Stanley, Nadine Melhem, Laurence Greenhill, Steven P. Ellis, David Kolko, Beth S. Brodsky, J. John Mann, David A. Brent 110. Brain Derived Neurotrophic Factor (BDNF) is Decreased in Platelets and Lymphocytes of Pediatric Patients with Bipolar Disorder Ghanshyam N. Pandey*, Yogesh Dwivedi, Hooriyah S. Rizavi, Xinguo Ren, Amal C. Mondal, Mani Pavuluri 125 Posters 2006.qxp 11/17/05 7:46 AM Page 126 Poster Session II—Tuesday 111. Resolution of Sleepiness and Fatigue in the Treatment of Major Depressive Disorder: A Comparison of Bupropion and the Selective Serotonin Reuptake Inhibitors George I. Papakostas*, David J. Nutt, Vivan L. Tucker, Alok Krishen, Maurizio Fava 112. Proton Magnetic Resonance Spectroscopy Study of the Effects of Lithium on Myo-Inositol in Bipolar Depressed Adolescents Nick C. Patel*, Melissa P. DelBello, Kim M. Cecil, Holly S. Bryan, Caleb M. Adler, Kevin E. Stanford, Stephen M. Strakowski 113. Electroconvulsive Seizures Increase Cell Proliferation in the Adult Monkey Cortex Tarique D. Perera*, Michael Persky, Michele Insanally, Alexander Sackeim, Jeremy Coplan, Andrew Dwork, Harold Sacheim 114. Pharmacological Characterization of the Novel 5-HT2C Agonist SCA-136: Antidepressant-Like Effects Sharon Rosenzweig-Lipson*, Jack Bergman, John Dunlop, Karen Marquis, Jean Zhang, Siva Ramamoorthy, Jessica Malberg, Claudine Pulicicchio, Hossein Mazandarani, Steve Grauer, Paul J. Mitchell, Boyd Harrison, Menelas N. Pangalos, Lee Schechter, Gary Stack 115. Constitutive Activation of the G-Protein Subunit G αs Causes Behavioral and Biochemical Deficits Due to a PKA-Dependent Upregulation of PDE Activity Michele Kelly, Michael Esposito, Jan Tokarczyk, Steve Siegel, Steve Kanes, Ted Abel* 116. Does Maintenance Treatment with Atypical Antipsychotics Worsen Quality of Life Among Stable Patients with Schizophrenia? Charles M. Beasley, Jr.*, Virginia K. Sutton, Cindy Taylor, Gopalan Sethuraman, Martin Dossenbach, Dieter Naber, David Pickar 117. Dopaminergic Modulation of Excitatory and Inhibitory Transmission in the Basolateral Amygdala-Prefrontal Cortex Pathway Stan B. Floresco*, Maric T. Tse 126 Posters 2006.qxp 11/17/05 7:46 AM Page 127 Poster Session II—Tuesday 118. Schizophrenia, Diabetic Ketoacidosis and Atypical Antipsychotic Agents David C. Henderson*, Enrico Cagliero, Paul M. Copeland, Pearl M. Louie, Christina P. Borba, Donald C. Goff 119. DISC1 Polymorphism in Schizophrenia: Associations with Cognition and MRI Brain Morphology Beng-Choon Ho*, Thomas H. Wassink 120. Temporal and Prefrontal Cortex Gray Matter Abnormalities in Patients with Schizophrenia and Their Unaffected Siblings; An Optimized VoxelBased Morphometry Study Robyn A. Honea*, Andreas Meyer-Lindenburg, Katherine Hobbs, Lukas Pezawas, Beth A. Verchinski, Aaron L. Goldman, Venkata S. Mattay, Daniel R. Weinberger, Joseph H. Callicott 121. Identification of a Novel Genetic Locus at 7q36.1 in Strong LD with Schizophrenia and the Differential Expression of the Flanking Genes, NOS3 and KCNH2 Stephen J. Huffaker*, Daniel R. Weinberger 122. Allelic Variations in NRG1 Affect Region-Specific Expression of Low Affinity Nicotinic Acetylcholine Receptors in the Human Brain Thomas M. Hyde*, Shiny V. Mathew, Barbara K. Lipska, Shruti N. Mitkus, Radhakrishna Vakkalanka, Richard E. Straub, Daniel R. Weinberger, Joel E. Kleinman 123. Treatment of Patients with Acute Schizophrenia Using Paliperidone Extended-Release Tablets: A 6-Week Placebo-Controlled Study John M. Kane*, Michelle Kramer, Lisa Ford, Christiana GassmannMayer, Pilar Lim, Marielle Eerdekens 124. A Comparison of the Effects of Olanzapine, Quetiapine, and Risperidone on Neurocognitive Function in First-Episode Psychosis Richard Keefe*, Hongbin Gu, Diana Perkins, Joseph McEvoy, Robert Hamer, Jeffrey Lieberman 127 Posters 2006.qxp 11/17/05 7:46 AM Page 128 Poster Session II—Tuesday 125. Relationship of Paternal Age to N-Acetyl-Aspartate in the Prefrontal Cortex in Schizophrenia Lawrence S. Kegeles*, Dikoma C. Shungu, Xiangling Mao, Raymond Goetz, Charles B. Mikell, Anissa Abi-Dargham, Marc Laruelle, Dolores Malaspina 126. Cardiac-Related Mortality in People with Schizophrenia Deanna L. Kelly*, Robert R. Conley, Robert P. McMahon, Raymond C. Love, Yang Yu, Tara Wagner 127. Cognitive Remediation and Social Cognition in Early Schizophrenia: Preliminary fMRI Data Matcheri S. Keshavan*, Vaibhav A. Diwadkar, Jeffrey J. Nutche, Gerald E. Hogarty 128. Factorial Structure of the Schedule for Deficit Syndrome in Schizophrenia David Kimhy*, Scott Yale, Raymond R. Goetz, Lynn Marcinko McFarr, Cheryl Corcoran, Dolores Malaspina 129. Association of Depressive Symptoms and Discontinuation from Schizophrenia Treatment: A Post-hoc Pooled Analysis of 4 Controlled Atypical Antipsychotic Treatment Trials Adam Meyers, David Adams, Haya Ascher-Svanum, Richard Mohs, Bruce Kinon* 130. Increased Brain Activation During Eye Gaze Discrimination in Schizophrenia Christian G. Kohler*, James Loughead, Kosha Ruparel, Tim Indersmitten, Ruben C. Gur 131. Abnormal Expression of NMDA Receptor Subunits and Interacting PSD Molecules in the Endoplasmic Reticulum in Schizophrenia Lars V. Kristiansen*, Vahram Haroutunian, James H. MeadorWoodruff 128 Posters 2006.qxp 11/17/05 7:46 AM Page 129 Poster Session II—Tuesday 132. Functional Effects of Haloperidol and Olanzapine over a 6-Week Treatment Period: Relation to Clinical Response Adrienne C. Lahti*, Henry H. Holcomb, Carol A. Tamminga, Martin A. Weiler 133. Prefrontal Cortical“UP” States in Adult Rat Brain Slice: Role of Glutamate Spillover and 5-HT2A Receptors Evelyn K. Lambe*, George K. Aghajanian 134. Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S. Kegeles, Gordon W. Frankle, Raj Narendran, Roberto Gil, Peter S. Talbot, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Slifstein Mark, Anissa Abi-Dargham 135. DRD2 Promoter Region Variation Predicts Sustained Response to Antipsychotic Medication in First Episode Schizophrenia Todd Lencz*, Delbert G. Robinson, Ke Xu, Jenny Ekholm, Serge Sevy, Handan Gunduz-Bruce, Margaret G. Woerner, John M. Kane, David Goldman, Anil K. Malhotra 136. Clozapine Effects on Memory Function are Reversed by Hippocampal Damage Edward D. Levin* 137. Synergetic Effects of Quetiapine and Venlafaxine in Preventing the Decrease in Cell Proliferation and BDNF Expression in Rat Hippocampus Caused by Chronic Restraint Stress Xin-Min Li*, Haiyun Xu 138. Remission in Schizophrenia: A Comparison of 2 Dose Regimens of Ziprasidone versus Haloperidol Treatment in a 3-Year Double-Blind Extension Study Jeffrey Lieberman*, Lewis Warrington, Antony Loebel, Cynthia Siu 139. Probing the Cognitive, Clinical, and Functional Impairments of Schizophrenia Patients with Mismatch Negativity Gregory A. Light*, Katrin Meyer-Gomes, Joyce Sprock, David L. Braff 129 Posters 2006.qxp 11/17/05 7:46 AM Page 130 Poster Session II—Tuesday 140. Role of Catechol-O-Methyltransferase Val/Met Polymorphism on P50 Sensory Gating in Schizophrenia Brett Y. Lu*, Kimberly Martin, Ashley K. Smith, Stephen F. Lewis, Gregory A. Miller, Jose M. Canive 141. The Prospective Study of Cannabis Use, Symptoms and Functioning in Patients Prodromal to Psychosis Cheryl Corcoran, David Kimhy, Yadira Sanchez, Jessica MacDonald, Herbert Kleber, Dolores Malaspina* 142. Symptomatic Remission in Schizophrenia Patients Treated with Aripiprazole or Haloperidol for up to 52 Weeks Anil Malhotra*, John Kane, David Crandall, Xiaoling Wu, William Carson, Dan Oren, Dusan Kostic, Wim Swyzen 143. Inhibition of the Glycine Transporter (GlyT1) Potentiates the Effect of Risperidone, but Not Clozapine, on Glutamatergic Transmission in the Rat Medial Prefrontal Cortex Monica M. Marcus*, Asa Konradsson, Peter Hertel, Torgny H. Svensson, Kent E. Jardemark 144. Efficacy and Tolerability of Two Fixed Dosages of Paliperidone ExtendedRelease Tablets in the Treatment of Acute Schizophrenia: A 6-Week Placebo-Controlled Study Stephen R. Marder*, Michelle Kramer, Lisa Ford, Els Eerdekens, Lim Pilar, Marielle Eerdekens 145. ERP P300 and Mismatch Negativity Abnormalities in Prodromal and Early Illness Schizophrenia: Predicting Conversion to Psychosis Daniel H. Mathalon*, Thomas H. McGlashan, Tandy J. Miller, Scott W. Woods 146. Comparison of Atypicals in First-Episode Psychosis (CAFE): A Randomized, 52-Week Comparison of Olanzapine, Quetiapine, and Risperidone Joseph P. McEvoy*, Joseph A. Lieberman, Diana Perkins, Robert M. Hamer 130 Posters 2006.qxp 11/17/05 7:46 AM Page 131 Poster Session II—Tuesday 147. Novel Targets of Quaking: A Gene Essential for Myelination That is Severely Reduced in Schizophrenia Lynne A. McInnes*, Sean Ryder 148. Comparison of Clozapine and High Dose Olanzapine in Treatment Resistant Schizophrenia in a Double Blind, Randomized, 6 Month Clinical Trial Karu Jayathilake, David O. Meltzer*, Joyce Small, Herbert Y. Meltzer 149. Comparative Effects of Ziprasidone and Olanzapine on Markers of Insulin Resistance: Results of a 6-Week Randomized Study in Patients with Acute Schizophrenia Jonathan Meyer*, Antony Loebel, Henry Nasrallah 150. Aripiprazole Effects on Highly Agitated Patients with Alzheimers’s Disease and Associated Psychosis Jacobo Mintzer*, Lindsay DeVane, Britt West, Joseph Pultz, Andrei Pikalov, Ronald Marcus, Rolando Gutierrez-Esteinou, David Crandall 151. A New Approach to Assessing Objective Functional Outcomes in Schizophrenia: A Validation Study Richard Mohs*, S Dube, L Bowman, B Kinon, L. Kleinman, L. Frank, D Revicki, Y Zhao 152. Error Feedback Negativity During a Learning Task in Schizophrenia Sarah E. Morris*, Erin A. Heerey, Benjamin M. Robinson, James M. Gold 153. Prefrontal Activity in Schizophrenia: An Interleaved TMS/fMRI Study Ziad Nahas*, Chris Molnar, Dave Ramsey, John Walker, Jejo Koola, Kevin Johnson, Richard Holt, Michael Horner, Frank A. Kozel, Stewart Denslow, Daryl Bohning, Mark S. George 154. Low Rates of Treatment for Metabolic Disorders in the CATIE Schizophrenia Trial at Baseline Henry A. Nasrallah* 131 Posters 2006.qxp 11/17/05 7:46 AM Page 132 Poster Session II—Tuesday 155. An Integrative Approach to Investigate Molecular Mechanisms Underlying Schizophrenia Using both Rat and Drosophila Melanogaster Charles Nichols*, Elaine Sanders-Bush 156. Association of the 5HT2C Gene Polymorphism and Antipsychotic-Induced Weight Gain Charles Nnadi*, Christoph U. Correll, Katherine E. Burdick, Jenny M. Ekholm, John M. Kane, Anil K. Malhotra 157. Genetic Analysis Supports a Primary Abnormality in Oligodendrocyte Function in Schizophrenia Michael O’Donovan*, Lyudmila Georgieva, George Kirov, Vahram Haroutunian, Kenneth L. Davis, Joseph D. Buxbaum, Michael Owen 158. The Consortium on the Gentics of Schizophrenia (COGS): The P50 Auditory Evoked Potential as an Endophenotype in a Large Multi-Site Study Ann Olincy*, Jamey Ellis, Robert Freedman 159. Learning to Relax with MRS: Altered NAA T2 Relaxation Times in Schizophrenia David P. Olson*, Joseph Coyle, Yong Ke, Staci A. Gruber, Isabelle Rosso, Marisa Silveri, Perry F. Renshaw, Deborah A. Yurgelun-Todd 160. Sleep Spindle Abnormalities in Schizophrenia Michael J. Peterson*, Fabio Ferrarelli, Reto Huber, Marcello Massimini, Steve K. Esser, Adam Watson, Giulio Tononi 161. A Double-Blind Placebo Controlled Trial of Modafinil for Negative Symptoms in Schizophrenia Joseph M. Pierre*, John H. Peloian, Donna A. Wirshing, William C. Wirshing, Stephen R. Marder 162. PCP- and Cocaine- Induced Changes in White Matter- Comparison with DTI Findings in Schizophrenia and Cocaine Dependence Jay Nierenberg*, David G. Guilfoyle, Matthew J. Hoptman, Daniel C. Javitt 132 Posters 2006.qxp 11/17/05 7:46 AM Page 133 Poster Session II—Tuesday 163. A Post-Marketing Observational Study of the Effects of Donepezil on Patients with Alzheimer Disease Jared R. Tinklenberg*, Helena C. Kraemer, Kristine Yaffe, Leslie Ross, J W. Ashford, Javaid Sheikh, Jerome A. Yesavage, Joy L. Taylor 164. Alterations in Sensorimotor Processing in Mice with Hyperdopaminergic or Hypomonoaminergic Tone William C. Wetsel*, Ramona M. Rodriguiz, Marc G. Caron 165. Candidate Gene Polymorphisms and Birth Weight (BW) in the National Longitudinal Study of Adolescent Health (Add Health) Redford Williams*, Melanie Kail, Marcy Speer, Beverly Brummett, Stephan Zuchner, Ilene Siegler, John Barefoot, Geeta Swamy, Haywood Brown, Marie L. Miranda, Allison Ashley-Koch 133 Posters 2006.qxp 11/17/05 7:46 AM Page 134 Poster Session III—Wednesday 1. Design, Synthesis and Application of Novel Tropane-Based Photoaffinity Labels Toward the Identification of Binding Domains on the Dopamine Transporter Amy H. Newman*, Mu-Fa Zou, Jianjing Cao, Joo H. Cha, John R. Lever, Theresa Kopajtic, Jonathan L. Katz, M. L. Parnas, Roxanne Vaughan 2. White Matter Changes in Cocaine Dependence Jay Nierenberg*, Laurie Nash, Matthew J. Hoptman, Jan Hrabe, Babak A. Ardekani, Gregory Bunt, Kelvin O. Lim, John Rotrosen 3. Prediction of Alcohol Problems Using A Prospective Longitudinal Design Including Genotype John I. Nurnberger*, R Wiegand, L Bierut, K Bucholz, T Foroud, H Edenberg, E T. Meyer, J Kramer, D Dick, W Reich, S Kuperman, V Hesselbrock, A Goate, B Porjesz, H Begleiter 4. Casein Kinase 1 Epsilon Modulates Sensitivity to Stimulant Drugs in Both Mice and Humans: A Translational Genetic Study Abraham A. Palmer*, Jeremy Veenstra-Vander Weele, Miguel Verbitsky, Rathi Suresh, Asfia Qaadir, Helen M. Kamens, John K. Belknap, T C. Gilliam, Edwin H. Cook, Tamara J. Phillips, Harriet De Wit 5. Cerebellar Vermis Participation in Cocaine-Related Behaviors Carl M. Anderson, Luis C. Maas, Blaise D. Frederick, Jacob T. Bendor, Thomas J. Spencer, Eli Livni, Scott E. Lukas, Alan J. Fischman, Bertha K. Madras, Perry F. Renshaw*, Marc J. Kaufman 6. Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in AlcoholDependent Self-Administering Rats Heather Richardson*, Laura E. O’Dell, Soon Y. Lee, George F. Koob, Catherine L. Rivier 134 Posters 2006.qxp 11/17/05 7:46 AM Page 135 Poster Session III—Wednesday 7. Sensitization-Prone C57BL/6J Mice Exhibit Reduced Dopamine D3 Receptor-Mediated Inhibition Relative to Sensitization-Resistant DBA/2J Mice Robert K. McNamara, Beth Levant, Benjamin Taylor, Rebecca Ahlbrand, Amy Liu, Kevin Stanford, Neil M. Richtand* 8. Rats Maintain Ethanol Self-Administration into the Posterior Ventral Tegmental Area (VTA) Despite the Aversive Effects of Bicuculline Zachary A. Rodd*, Scott M. Oster, Jamie E. Toalston, James M. Murphy, Richard L. Bell, Ting-Kai Li, William J. McBride 9. Exposure to Cues Associated with Palatable Food Increases ImmediateEarly Gene (IEG) mRNA and Proenkephalin (PENK) premRNA Expression in the Rat Brain Craig A. Schiltz*, Ann E. Kelley, Charles F. Landry 10. Ontogeny of the HPA-Axis and Monoamine Response to Acute Ethanol Challenge in Male and Female Adolescent Rhesus Macaques Melanie L. Schwandt*, Christina S. Barr, Stephen J. Suomi, James D. Higley 11. Aripiprazole Attenuates Cocaine-Seeking Behavior in an Animal Model of Relapse Ronald E. See*, Matthew W. Feltenstein, C. A. Altar 12. Chronic, but Not Acute, Desipramine Treatment Prevented Nicotine Withdrawal and Decreased Nicotine Self-Administration in Rats Svetlana Semenova*, Neil E. Paterson, Athina Markou 13. Positron Emission Tomographic Study of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and Without Comorbid Alcohol Dependence Leo Sher*, Matthew S. Milak, Ramin V. Parsey, Thomas B. Cooper, Juan J. Carballo, Maria A. Oquendo, J J. Mann 14. NMDA Receptors Mediate Some of the Lingering Behavioral Deficits of Repeated Ethanol Exposure in Adolescent Rats Ratna Sircar* 135 Posters 2006.qxp 11/17/05 7:46 AM Page 136 Poster Session III—Wednesday 15. Selective Enhancement of Limited Access Ethanol Intake in IsolateHoused Alcohol-Preferring (P) Rats Craig J. Slawecki*, Cindy L. Ehlers 16. Amphetamine Effects on Amygdala Responses to Affective Pictures in Healthy Volunteers Tara L. White, Robert M. Swift*, Ronald A. Cohen, Lawrence H. Sweet 17. The Effects of MDMA (Ecstasy) on Sleep Architecture and Mood in Humans Manuel E. Tancer*, Timothy Roehrs, Chris-Ellyn Johanson 18. Positive and Negative Transcription Regulation of NR2B Gene in Basal and Ethanol-Induced Gene Expression in Fetal Cortical Neurons Maharaj K. Ticku*, Mei Qiang 19. An Open Label Pilot Trial of Atomoxetine and Four-Session Motivational Interviewing for Cannabis Dependence Carlos F. Tirado*, Nathalie Maullin, Kampman Kyle, Lauren Klein, Charles O’Brien 20. Brain Stimulation Reward Thresholds Are Altered by Viral VectorMediated Elevations of GluR Subunits Within the Nucleus Accumbens Shell Mark S. Todtenkopf*, Rachael L. Neve, William A. Carlezon 21. The Impact of Screening, Brief Intervention, and Referral to Treatment (SBIRT) on Emergency Department(ED) Patients’ Alcohol Use Kimberly Walton*, Research Collaborative The Academic ED SBIRT, Robert E. Taylor 22. Effects of Acute Plasma Tryptophan Depletion on Serotonin Receptor Binding Using PET in Healthy Controls: Implications for Alcoholic Brain Disease Wendol A. Williams*, Richard E. Carson, Andreas Heinz, James Bjork, Mary-Anne Enoch, Christopher Geyer, Robert Rawlings, Daniel Hommer, David Goldman, Peter Herscovitch 136 Posters 2006.qxp 11/17/05 7:46 AM Page 137 Poster Session III—Wednesday 23. Baseline Data from CTN Study 0010: Buprenorphine/Naloxone Facilitated Psychosocial Treatment for Opioid Dependent Adolescents/Young Adults George E. Woody*, Sabrina Poole, Forman Robert, Blaine Jack 24. A Large-Scale Approach for Identifying Vulnerability Genes to Alcoholism: A 1536 SNP Chip Ke Xu*, Qiaoping Yuan, Colin A Hodgkinson, Pei-Hong Shen, Lisa Neuhold, Zhaoxia Ren, Kenneth Warren, David Goldman 25. Nicotinic Agonists Inhibit Reinstatement of Methamphetamine-Seeking Behavior in Rats Tsuneyuki Yamamoto*, Takato Hiranita, Kusnandar Anggadiredja 26. Diffusion Tensor Imaging Measures Correlate with Cognitive Performance in Heavy Cannabis Smokers Staci A. Gruber, Deborah A. Yurgelun-Todd* 27. Region and Emotion Specific Effects of Lorazepam on Neural Responses to Facial Displays of Affect K. Luan Phan*, Mike Angstadt, Daniel A. Fitzgerald, Pradeep J. Nathan, Royce Lee, Emil F. Coccaro 28. Reproducibility of Proton Spectroscopic Imaging (H1-MRSI) at 3Tesla: Effects of Corrections for B1 Field and Partial Volume Stefano Marenco*, Douglas W. Jones, Alan S. Barnett, Jan Willem Van der Veen, Aronica Cotton, Daniel R. Weinberger 29. Neuroticism, Extraversion and Alexithymia Are Associated with Differential Neural Activation Patterns to Emotional Stimuli Jennifer C. Britton, Brian Martis*, Shao-Hsuan Ho, Stephan F. Taylor, Israel Liberzon 30. Magnetic Resonance Spectroscopic Imaging Twenty Years After the Emergence of Adolescent-Onset Major Depressive Disorder Sanjay J. Mathew*, Dikoma C. Shungu, Xiangling S. Mao, Heidi Fitterling, Jonathan M. Amiel, Eric L. Smith, Adriana Feder, Jeremy D. Coplan, Myrna M. Weissman 137 Posters 2006.qxp 11/17/05 7:46 AM Page 138 Poster Session III—Wednesday 31. COMT val158met Polymorphism Impacts on Reactivity of Amygdala to Emotion Laden Stimuli Venkata S. Mattay*, Giuseppe Blasi, Guilna Alce, Saumitra Das, Joseph H. Callicott, Bhaskar S. Kolachana, Michael F. Egan, Fabio Sambataro, Andreas Meyer-Lindenberg, Ahmad R. Hariri, Daniel R. Weinberger 32. Irritable Bowel Syndrome and Increased Anxiety in Healthy Females, but Not in Healthy Males, is Associated with Increased Size of a Midbrain Region Activated During Inescapable Pain Steven M. Berman, Joshua Bueller, Brandall Suyenobu, Edythe London, Lin Chang, Bruce D. Naliboff, Emeran A. Mayer* 33. Increased Basal Ganglia Activity During Interferon-Alpha Therapy for Malignant Melanoma: Relationship with Neurovegetative Symptoms Lucile Capuron, Giuseppe Pagnoni, Marina Demitrashvili, David H. Lawson, Gregory S. Berns, Charles B. Nemeroff, Andrew H. Miller* 34. Distribution of [11C]PIB in a Nondemented Population: Implication for Use as an Antecedent Marker of Alzheimer’s Disease Mark A. Mintun*, Gina N. LaRossa, Yvette I. Sheline, Sang Y. Lee, Carmen S. Dence, Mach H. Robert, William E. Klunk, Chester A. Mathis, Steven T. DeKosky, John C. Morris 35. Positron Emission Tomography of Brain 5HT1A Receptor Binding with [11-C]WAY100635 in Postpartum Depressed and Nondepressed Women Eydie L. Moses-Kolko*, Katherine L. Wisner, Julie C. Price, Sarah L. Berga, Chester Mathis, Wayne C. Drevets, Andrea L. Confer, Carl Becker, Carolyn C. Meltzer 36. The Sensitivity of the Loudness Dependence Auditory Evoked Potential (LDAEP) as a Measure of Central Serotonin Function in Humans Pradeep J. Nathan*, Barry O’Neill, Julian Simmons, Nick Allen, Matthew P. Galloway, K L. Phan, Rodney J. Croft 37. FDG-PET in Laboratory Induced Aggression in Borderline Personality Disorder Antonia S. New*, Roanna Trisdorfer, Erin A. Hazlett, Randall E. Newmark, Monte S. Buchsbaum, Larry J. Siever 138 Posters 2006.qxp 11/17/05 7:46 AM Page 139 Poster Session III—Wednesday 38. Acute Occupancy of Brain Serotonin Transporter by Sertraline as Measured by [11C]DASB and Positron Emission Tomography Ramin V. Parsey*, Justine M. Kent, Maria A. Oquendo, Misty Richards, Mali Pratap, Thomas Cooper, Victoria Arango, J. J. Mann 39. Lorazepam Dose-Dependently Decreases Risk-Taking Related Activation in the Caudate Martin P. Paulus*, Estibaliz Arce, Murray B. Stein 40. An fMRI Study of the Interface Between Affective and Cognitive Circuitry in Pediatric Bipolar Disorder Mani N. Pavuluri*, Aryal Subhash, Megan M. O’Connor, Erin Harral, Ellen Herbener, John A. Sweeney 41. FDG and PIB PET Imaging in Alzheimer’s Disease and Mild Cognitive Impairment Julie C. Price*, Scott K. Ziolko, Lisa A. Weissfeld, William E. Klunk, Brian J. Lopresti, Jessica A. Hoge, Xueling Lu, Wenzhu Bi, Carolyn C. Meltzer, Nicholas Tsopelas, Steven T. DeKosky, Chester A. Mathis 42. Imaging Neuroinflammation in Alzheimer Disease with [111C]Arachidonic Acid and Positron Emission Tomography Stanley I. Rapoport*, Richard E. Carson, Abesh Bhattacharjee, Mark B. Schapiro, Giuseppe Esposito, Peter Herscovitch, William C. Eckelman, Giuseppe Esposito 43. A Voxel-Based, Whole Brain MRI Analysis of Adolescents with Psychotic Illnesses Donald C. Rojas*, David B. Arciniegas, Peter Teale, Olivia Hernandez, Martin L. Reite 44. Localization of Increased White Matter Hyperintensities in Late Life Depression Using an Automated Voxel-Wise Method Yvette Sheline*, Robert McKinstry, Deanna Barch, Avi Snyder, Asif Moinuddin, Consuelo Wilkins, Jon Christensen, Mark Mintun 139 Posters 2006.qxp 11/17/05 7:46 AM Page 140 Poster Session III—Wednesday 45. Effects of Lithium Treatment on Human Brain Structure Mapped Using Longitudinal MRI Alex D. Leow, Paul M. Thompson, Kiralee M. Hayashi, Carrie Bearden, Mark A. Nicoletti, Serap E. Monkul, Roberto B. Sassi, Paolo Brambilla, Alan G. Mallinger, Jair Soares* 46. Marked Deficits in Membrane Phospholipid Precursor Levels in AttentionDeficit/Hyperactivity Disorder (ADHD) Children with Comorbid Diagnoses Jeffrey A. Stanley*, Matcheri S. Keshavan, Heidi Kipp, Erika Greisenegger, Kanagasabai Panchalingam, Jay W. Pettegrew, Oscar G. Bukstein 47. GABRA2 Genetic Variation and Response of the Human Amygdala and Insula to Fearful Faces Murray B. Stein*, Martin P. Paulus, Joel Gelernter 48. Diffusion Tensor Imaging: Fractional Anisotropy in White Matter, Symptom Severity, and Cognition in the Brains of Schizophrenia Patients Daniel G. Stewart*, Joseph I. Friedman, Cheuk Tang, Jack Gorman, Phil Harvey, David Carpenter, Arash Hajianpour, Johnny Ng, Patrick Hof, Monte Buchsbaum, Kenneth L. Davis 49. Physiological Correlates of a Non-Working Memory Prefrontal Task Steven Sust*, Joshua Buckholtz, Brad Zoltick, Doug Jones, Bart Rypma, Hao Y. Tan, Venkata Mattay, Daniel R. Weinberger, Joseph Callicott 50. The Development of Human Parent-Infant Attachment: Functional Brain Imaging During the Early Postpartum James E. Swain*, James F. Leckman, Linda C. Mayes, Ruth Feldman, Robert T. Schultz 51. Rolling with the Punches: Emotional Resilience and Ventral Prefrontal Cortex Stephan Taylor*, Christian E. Waugh, Tor D. Wager, Douglas C. Noll, Barbara L. Fredrickson 140 Posters 2006.qxp 11/17/05 7:46 AM Page 141 Poster Session III—Wednesday 52. Evidence for Sensitive Periods in the Effects of Childhood Abuse on Regional Brain Morphology Martin H. Teicher*, Susan L. Andersen, Akemi Tomoda, Ann Polcari, Evelyn Vincow, Elizabeth Valente 53. Allelic Variation of PPP1R1B, Encoding DARPP-32, Affects Human Striatal Volume and Striatal-Prefrontal Structural Connectivity Beth A. Verchinski*, Andreas Meyer-Lindenberg, Lukas Pezawas, Richard Straub, Robyn Honea, Aaron L. Goldman, Katherine Hobbs, Joshua W. Buckholtz, Joseph H. Callicott, Bhaskar Kolachana, Venkata S. Mattay, Daniel R. Weinberger 54. Gastric Stimulation Activates Brain Satiety Circuiy Gene-Jack Wang* 55. 123I-ADAM SPECT Study in Patients with Major Depression: Serotonin Transporter Occupancy Induced by Paroxetine and Relationship with Clinical Response Victor S. Perez*, Ana Catafau, P Plaza, JC Pascual, S Bullich, M Danus, D Puigdemont, I Corripio, MM Penengo, J Perich, E Alvarez 56. Epistasis of SERT & BDNF: A Mechanistic Model of Depression Lukas Pezawas*, Aaron L. Goldman, Beth A. Verchinski, Venkata S. Mattay, Gang Chen, Katherine Hobbs, Robyn A. Honea, Joseph S. Callicott, Bhaskar S. Kolachana, Richard E. Straub, Michael F. Egan, Andreas Meyer-Lindenberg, Daniel R. Weinberger 57. Associations in the Longitudinal Course of Body Dysmorphic Disorder with Major Depression, OCD, and Social Phobia Katharine A. Phillips*, Robert L. Stout 58. Toward the Identification of Biological Markers of Bipolar Disorder: A First Stage Neuroimaging Study Mary L. Phillips*, Cecile D. Ladouceur, Stefanie Hassel, Natalie Kerr, Greg Siegle, Kate Fissell, Simon Surguladze, Michael E. Thase, David J. Kupfer 141 Posters 2006.qxp 11/17/05 7:46 AM Page 142 Poster Session III—Wednesday 59. Shared Genetic Contributions to Pathological Gambling and Major Depression in Men Marc N. Potenza*, Hong Xian, Kamini R. Shah, Jeffrey F. Scherrer, Seth A. Eisen 60. Adolescent Depression and Neuronal Circuits Associated with Reward Processes Uma Rao*, Anup Bidesi, Monique Ernst, Carol Tamminga 61. Depression-Insulin Resistance Link Natalie L. Rasgon*, Margaret F. Reynolds, Laurel N. Zappert, Heather A. Kenna, M.A. 62. Pediatric Bipolar Disorder and Face Processing: Neural and Behavioral Deficits Brendan A. Rich*, Deborah T. Vinton, Lisa Berghorst, Erin B. McClure, Daniel S. Pine, Ellen Leibenluft 63. Role of CRF2 Receptors in Maintenance and Recovery from CRF1 Receptor-Induced Alterations in Defensive Startle Victoria B. Risbrough*, Sarah Coste, Mary Stenzel-Poore, Mark Geyer 64. Safety and Tolerability of the Selegiline Transdermal System 20 mg for Treatment of Major Depression Donald S. Robinson*, Bryan J. Campbell, Jay D. Amsterdam 65. Alterations in Human Amygdala Corticotropin-Releasing Factor (CRF) Receptor Binding Associated with Psychiatric Illness Patrick H. Roseboom*, Dimitri E. Grigoriadis, Susan K. Sullivan, Ryan J. Herringa, Ned H. Kalin 66. A “Pharmacological Stressor” Model of Anxiolysis in Monkeys: Alprazolam Attenuation of the Behavioral and Physiological Effects of Yohimbine Melissa A. Birkett, Donna M. Platt, Stefan Tiefenbacher, James K. Rowlett* 142 Posters 2006.qxp 11/17/05 7:46 AM Page 143 Poster Session III—Wednesday 67. Adjunctive Topiramate Therapy in Patients Receiving a Mood Stabilizer for Bipolar I Disorder: A Randomized, Placebo-Controlled Trial K.N. Roy Chengappa*, Lesley K. Schwarzmann, Joseph F. Hulihan, Jim Xiang, Norman R. Rosenthal 68. Is the Association of PTSD and Poor Health Due to a Common Familial or Genetic Factor? Peter P. Roy-Byrne*, Carolyn Noonan, Niloo Afari, Dedra Buchwald, Jack Goldberg 69. Blockade of Angiotensin II AT1 Receptors Decreases Anxiety and Prevents the Isolation Stress-Induced Decrease in Cortical CRF1 Receptors and Benzodiazepine Binding Juan M. Saavedra* 70. Antimanic Response to Aripiprazole with High vs. Low Agitation Gary Sachs*, Jerrold Rosenbaum, Joseph Pultz, Andrei Pikalov, Christopher Breeder, Dusan Kostic, David Crandall 71. Paroxetine Treatment of Compulsive Hoarding Sanjaya Saxena*, Arthur L. Brody, Karron M. Maidment, Lewis R. Baxter 72. The Nucleus Accumbens as Target for Deep Brain Stimulation for Treatment Refractory Depression Thomas E. Schlaepfer*, Doris Lenartz, Caroline Frick, Volker Sturm 73. Time Course of Depressive Symptomatology During Vagus Nerve Stimulation: Comparisons of US and European Results Caroline Frick, Stephen Brannan, Mustafa Hasdemir, Zeno Stanga, Markus Kosel, Hans-Ulrich Fisch, Thomas E. Schlaepfer* 74. Prospective Study of Plasma Stress Hormones in PTSD Arieh Y. Shalev*, Ronen Segman, Roger K. Pitman, Yair Bannet, Rachel Yehuda 75. Risperidone vs. Bupropion Combined with SSRIs in Treatment Resistant Unipolar Major Depression Richard C. Shelton*, Stephanie Addington, Vatsal Thakkar 143 Posters 2006.qxp 11/17/05 7:46 AM Page 144 Poster Session III—Wednesday 76. Effects of Chronic Prednisone Therapy on Mood and Memory: A FollowUp Study E. Sherwood Brown*, Elizabeth Vera, Alan B. Frol, Dixie J. Woolston, Brandy Johnson 77. Effect of Two Prednisone Exposures on Mood and Declarative Memory E. Sherwood Brown*, Laura Beard, Alan B. Frol 78. In Vivo Effects of Lithium on Synaptic Plasticity and Levels of BDNF and Phospho-CREB in Hippocampus Seong Shim*, Michael Hammonds, Joseph Calabrese 79. Efficacy and Tolerability of Low Doses of Paroxetine CR in Elderly Outpatients with Major Depression Ram K. Shrivastava*, Saraswatiben P. Shrivastava, Johanna Landinez, Cornelius D. Pitts, Desiree M. Schaefer, Alan Lipschitz, Malini Iyengar 80. Efficacy of Ziprasidone in Dysphoric Mania: Pooled Analysis of 2 DoubleBlind Studies Stephen M. Stahl*, Illise Lombardo, Antony Loebel, Francine Mandel 81. A Single-Blind Prospective Study of Quetiapine for the Treatment of Mood Disorders in Adolescents Who Are at High Risk for Developing Bipolar Disorder Stephen M. Strakowski*, Melissa P. DelBello, Robert Kowatch, Rachel Whitsel, Cal Adler 82. Manic Symptoms During Bipolar Depression: Impulsivity and Suicidality Alan C. Swann*, Joel L. Steinberg, Frederick G. Moeller 83. Galanin-Evoked Reductions in Serotonergic Neurotransmission in the Hippocampus and Dorsal Raphe Nucleus Are Attenuated by GAL3 Receptor Antagonists Chad J. Swanson*, Xuexiang Zhang, Kang Zheng, Zhi-Qing D. Xu, Tomas Hokfelt, Heidi Chen, Michael J. Konkel, Huailing Zhong, Mary M. Walker, Thomas P. Blackburn, Theresa A. Branchek, Christophe P. Gerald, Douglas A. Craig 144 Posters 2006.qxp 11/17/05 7:46 AM Page 145 Poster Session III—Wednesday 84. Decreased Serotonin-1A Receptor Binding in Social Anxiety Disorder Rupert Lanzenberger, Christoph Spindelegger, Alexander Holik, Key Mien, Markus Mitterhauser, Wolfgang Wadsak, Nilufar Mossaheb, Trawat Attarbaschi, Julia Sacher, Nikolas Klein, Kurt Kletter, Siegfried Kasper, Johannes Tauscher* 85. Using Symptom Improvement Patterns to Predict Remission in Depressed Outpatients Treated with Venlafaxine Extended Release (XR) or Selective Serotonin Reuptake Inhibitors (SSRI) Madhukar H. Trivedi*, Bruce D. Grannemann, Jeff Musgnung, Qin Jiang, Raj Tummala, Michael E. Thase 86. Inhibited Temperament and HPA Axis Function in Healthy Adults Audrey R. Tyrka*, Linda Carpenter, George Anderson, Lawrence Price 87. Antidepressant Treatment and Risk of Suicide Attempt by Adults with Major Depressive Disorder: A Propensity-Adjusted Retrospective Cohort Study Robert J. Valuck*, Anne M. Libby, Elaine H. Morrato, Maria A. Oquendo, Hendricks Brown, Robert D. Gibbons 88. Mitochondrial Related Gene Expression In Suicide Marquis P. Vawter*, Simon J. Evans, Prabha V. Choudary, Fan Meng, Mary E. Atz, Preston Cartagena, David M. Walsh, Jun Li, Hiro Tomita, Richard M. Myers, Huda Akil, Stanley J. Watson, Edward G. Jones, William E. Bunney 89. Altered Sensitivity of Peripheral Blood Leukocytes to Glucocorticoids in Deployment-Related Postraumatic Stress Disorder Eric Vermetten*, Carien De Kloet, Annemieke Kavelaars, Angela Bikker, Ellen Meulman, Herman G. Westenberg, Cobi J. Heijnen 90. Evidence That SSRI Response in Depression Is Influenced by a Functional Haplotype in HTR1B and the C-1019G SNP in HTR1A Sandra M. Villafuerte*, Elizabeth A. Young, Margit Burmeister 145 Posters 2006.qxp 11/17/05 7:46 AM Page 146 Poster Session III—Wednesday 91. The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress Gary Wand*, Rachel Chong, Lynn Oswald, Xiaoju Yang, Magdalena Uhart, Ping Lin 92. 5HTTLPR Genotypes and Environmental Stress Interact to Affect Sleep Quality Beverly Brummett, Allison Ashley-Koch, Cynthia Kuhn, Melanie Kail, Jeffery Vance, Stephan Zuchner, Ilene Siegler, John Barefoot, Redford Williams* 93. Evidence of Increased CRH Pulsatility in Major Depression Elizabeth A. Young*, Morton B. Brown, Saulo Ribeiro 94. Identifying the Most Sensitive Measures and Definitions of Outcome for Pediatric Bipolar Disorder Eric A. Youngstrom*, Mark D. Cooperberg, Joseph R. Calabrese, Robert L. Findling 95. Robust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A Double-Blind Placebo-Controlled Study Carlos A. Zarate*, Jaskaran Singh, Paul Carlson, Nancy Brutsche, Rezvan Ameli, David Luckenbaugh, Dennis S. Charney, Husseini K. Manji 96. Responsiveness of Mice Deficient in Beta Adrenergic Receptors to Desipramine and Beta Adrenergic Agonists: Behavioral Effects Observed Using the Forced-Swim Test (FST) and Differential-Reinforcement-ofLow-Rate (DRL) Schedule Hanting Zhang*, Lisa R. Stolinski, Ying Huang, James M. O’Donnell 97. Lithium Regulates P2X7 Receptor Expression and ATP Activation in Astrocytes: A Novel Therapeutic Target in the Treatment of Bipolar Disorder? Lei Zhang*, James E. Barrett, Husseini K. Manji 146 Posters 2006.qxp 11/17/05 7:46 AM Page 147 Poster Session III—Wednesday 98. Abnormal Expression of Transcripts for GKAP and Shank Suggest Alterations of Interactions Between Metabotropic and Ionotropic Glutamate Receptors in Schizophrenic Brain James H. Meador-Woodruff*, Eduardo Reyes, Vahram Haroutunian, Lars V. Kristiansen 99. Correlations Between REM Sleep EEG Spectral Analysis and CSF GABA in Clinically Stable Drug-Free Patients with Schizophrenia: A Pilot Study Julie Poulin*, Daniel P. Van Kammen, Mary E. Kelley, Roger Godbout, Thomas C. Neylan, Eric A. Nofzinger, Jeffrey L. Peters, Guochuan E. Tsai 100. Medial Temporal Lobe Structures and RGS4 Polymorphisms in FirstEpisode Schizophrenia Konasale M. Prasad*, Kodavali V. Chowdari, Michael E. Talkowski, David A. Lewis, Vishwajit L. Nimgaonkar, Matcheri S. Keshavan 101. The Consortium on the Genetics of Schizophrenia (COGS): Reliability and Validity of Standardized Assessement of Basic Oculomotor Function in Schizophrenia Patients, First Degree Relatives and Controls in a Multisite Study Allen D. Radant*, Dorcas J. Dobie, Monica E. Calkins, Ann Olincy, Sean P. Meichle, Debby W. Tsuang 102. Disrupted Integration of Prefrontal and Hippocampal Activation in Schizophrenia During Word Encoding and Recognition John D. Ragland*, Dan Wolf, Mark Elliott, Jeffrey N. Valdez, Ruben C. Gur, Raquel E. Gur 103. Bilateral Reduction of Caudate Volumes in the Young, Asymptomatic, Genetically at Risk Offspring of Patients with Schizophrenia RP Rajarethinam*, Ameet Upadhyaya, Pon Tsou, Margi Upadhyaya, Jeffrey Nutche, Matcheri Keshavan 104. The Orexin-1 Receptor Antagonist SB-334867 Reverses the Depolarization Inactivation of A9 and A10 Dopamine Neurons Caused by Chronic Administration of Haloperidol and Olanzapine Kurt Rasmussen*, Kalpana Merchant, Yili Yang 147 Posters 2006.qxp 11/17/05 7:46 AM Page 148 Poster Session III—Wednesday 105. Second-Generation Antipsychotic Exposure and Patterns of Change in Metabolic Adverse Effects: A Longitudinal Pharmacoepidemiology Study from 1988 to 2002 Chris Reist*, Lawrence Albers, Sandor Szabo, Mazan Jamal, Mehrtash Hashemzadeh, Vural Ozdemir 106. MEG Gamma Band Activity Reduced in Psychotic Adolescents Keeran Maharajh, Peter Teale, Don Rojas, Martin Reite* 107. Randomized Comparison of Olanzapine versus Risperidone for the Treatment of First Episode Schizophrenia: Four Month Outcomes Delbert G. Robinson*, Margaret Woerner, Barbara Napolitano, Raman Patel, Serge Sevy, Handan Gunduz-Bruce, Jose Soto-Perello, Alan Mendelowitz, Ali Khadivi, Rachel Miller, Joanne McCormack, Beth Lorell, Martin Lesser, Nina Schooler, John Kane 108. Olanzapine and Clozapine Rapidly Decrease Whole-Body Insulin Sensitivity in Rats: Implications for the Diabetic Liability of Certain Antipsychotics K L. Houseknecht, A S. Robertson, E M. Gibbs, W J. Zavadoski, F M. Nedza, D E. Johnson, B K. Koe, H Rollema* 109. Alteration of Amygdala Inputs to Entorhinal Cortex Through Dopaminergic Modulation of Voltage-Gated Ion Channels Amiel Rosenkranz*, Daniel Johnston 110. Antipsychotic-Like Effects of SCA-136: A Novel 5-HT2C Receptor Agonist Karen L. Marquis, Nancy Ator, John Dunlop, Siva Ramamoorthy, Chad Beyer, Qian Lin, Julie Brennan, Michael Piesla, Charles Ashby, Boyd Harrison, Ron Magolda, Menelas N. Pangalos, Gary Stack, Sharon Rosenzweig-Lipson* 111. Efficacy of Ziprasidone in Schizophrenic Subjects with Differing Levels of Agitation Nina R. Schooler*, Jacobo Mintzer, Antony Loebel, Ruoyong Yang 148 Posters 2006.qxp 11/17/05 7:46 AM Page 149 Poster Session III—Wednesday 112. A Pharmacogenetic Test for Prediction of Vulnerability to Tardive Dyskinesia Ronnen H. Segman*, Tanya Goltser - Dubner, Fabio Macciardi, Bernard Lerer 113. Neuregulin1-Induced Cell Migration of B Lymphoblasts: Possible Association with Schizophrenia Yoshitatsu Sei*, Renee Ren-Patterson, Zhen Li, Elizabeth M. Tunbridge, Michael F. Egan, Bhaskar S. Kolachana, Daniel R. Weinberger 114. Differential Methamphetamine-Induced Immediate Early Gene Expression in the Prefrontal Cortex of High Versus Low Responders Paul D. Shilling*, Ronald Kuczenski, David S. Segal, Thomas B. Barrett, John R. Kelsoe 115. Disruption of Startle Gating in Rats After Systemic D1 Blockade Is Independent of Prefrontal Cortex and Changes in Sensory Gating. Jody M. Shoemaker*, Gregory A. Light, Michelle Breier, Hubertus H. Voet, Richard L. Saint Marie, Alaina C. Neary, Neal R. Swerdlow 116. Frequency Mismatch Negativity in Mice is Attenuated by Ketamine Steven J. Siegel*, Richard S. Ehrlichmen, Christina Maxwell, Sonalee Majumdar 117. Metabolic Responses to Fatty Meal in Schizophrenic Patients Treated with Olanzapine or Risperidone Robert C. Smith*, Jean-Pierre Lindenmayer, Erin Kelly, Adriana Buga, Melissa Matute, Sumathi Vaidhyanathaswamy, Nabila Sheikh, Tom Viviano, Santica M. Marcovina 118. Effects of Smoking and Nicotine Nasal Spray on Cognitive Function in Schizophrenic Smokers, Schizophrenics Non-Smokers, and Non-Psychotic Smokers Erin Kelly, Robert C. Smith*, Anantha Shekhar, Fredrick Molloy, Timothy Steadman, Nabila Sheikh, Meaghan Kuczora, Alea Khan 149 Posters 2006.qxp 11/17/05 7:46 AM Page 150 Poster Session III—Wednesday 119. Effectiveness and Tolerability Outcomes of Risperidone Long-Acting Injection Compared to Conventional Depot Antipsychotics in a Canadian Psychiatric Hospital Mark Snaterse*, Ron Welch, Pierre Chue 120. Evidence for Epigenetic Regulation of the 5HT2A Receptor Gene (5HT2AR). Methylation of Allele C-Specific CpG Sites in 5HT2AR Correlates with its Expression and eRobust, Rapid and Relatively Sustained Antidepressant Effects with a Single-Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A Double-Blind Placebo-Controlled Study Expression of DNA Methylase DNMT1 Oxana O. Polesskaya, Christopher Aston, Boris P. Sokolov* 121. Deficit Syndrome and Memory Function in Schizophrenia Arielle D. Stanford*, Ronald B. Chin, Binu Thomas, Elena Ivleva, Carol A. Tamminga 122. MUTED (6p24.3), a Protein That Binds to Dysbindin (DTNBP1, 6p22.3), Is Strongly Associated with Schizophrenia and Exhibits Statistical Epistasis with COMT Richard E. Straub*, Michael B. Mayhew, Radha K. Vakkalanka, Bhaskar Kolachana, Terry E. Goldberg, Michael F. Egan, Daniel R. Weinberger 123. Bifeprunox: Relationship Between Antipsychotic Potential, EPS Liability and Dopamine D2 Receptor Occupancy in Rats Peter Hertel, L Brennum, L Helboe, C K Olsen, M Kreilgard, Karen Marquis, Torgny Svensson*, A H J Herremans, Mayke Hesselink 124. Enhanced Cortical Dopamine Output and Antipsychotic-Like Effect of Raclopride by Low Dose L-Dopa Torgny Svensson*, Marie-Louise Wadenberg, Amani Eltayb 125. Effects of Memantine on Startle Gating in Normal Adult Men Neal R. Swerdlow*, Ashley N. Sutherland, Monique P. Tillemans, Jo A. Talledo 150 Posters 2006.qxp 11/17/05 7:46 AM Page 151 Poster Session III—Wednesday 126. Lower Anterior Cingulate Grey Matter Volume in Antipsychotic DrugNaive First-Episode Schizophrenia Patients with Cannabis Use Philip R. Szeszko*, Serge Sevy, Delbert G. Robinson, Sanjiv Kumra, Claudia I. Rupp, Julia Betensky, Todd Lencz, Manzar Ashtari, John Kane, Anil K. Malhotra, Handan Gunduz-Bruce, Barbara Napolitano, Robert M. Bilder 127. Distinct Roles for Different Homer1 Isoforms in Behaviors Associated with Prefrontal Cortex Function in vivo Karen K. Szumlinski*, Kevin D. Lominac, Peter W. Kalivas 128. Asenapine Displays Unique Long-Term Molecular Effects on Dopamine Receptor Subtypes Frank I. Tarazi*, Taylor Moran-Gates, Carla Massari, Erik HF Wong, Brian Henry, Mohammed Shahid 129. A Double-Blind, Placebo-Controlled Study of Olanzapine in Adolescents with Schizophrenia Ludmila Kryzhanovskaya, Charles Schulz, Christopher J. McDougle, Jean A. Frazier, Joan Shen, Ralf Dittman, Carol Robertson-Plouch, Theresa Bauer, Wen Xu, Wei V. Wang, Janice Carlson, Sara Corya, Mauricio Tohen* 130. COMT Inhibition Enhances Neuregulin-Induced Cell Migration in B Lymphoblasts Elizabeth Tunbridge*, R Ren-Patterson, Z Li, J Chen, J Apud, M Egan, B Kolachana, P J. Harrison, Y Sei, D R. Weinberger 131. Chromosome 7q PTC Non-Taster Haplotype is Associated with Schizophrenia Bruce I. Turetsky*, Stephen J. Kanes, Mya E. Levy, Paul J. Moberg 132. The COMT Val158Met Polymorphism and Cognition in Schizophrenia Elizabeth W. Twamley*, Jenille M. Narvaez, David I. Sitzer, John R. Kelsoe 133. Identification of an Interaction Between the Dopamine D1 Receptor and Niemann-Pick C1 Protein Gabriel Vargas*, Stanford Chen, Mark Von Zastrow 151 Posters 2006.qxp 11/17/05 7:46 AM Page 152 Poster Session III—Wednesday 134. Are Self-Reports and Physician Impressions of Adherence to Oral Antipsychotics Related to Objective Measures? Dawn I. Velligan*, Mei Wang, Desiree Castillo, Scott Bendle, Francis Lam, Larry Ereshefsky, Pamela Diamond, Alexander L. Miller 135. Neuroscience-Guided Cognitive Training in Schizophrenia: Preliminary Data Sophia Vinogradov*, Christine Holland, Michael Merzenich 136. Treatment of Cardiac Risk Factors in Patients with Schizophrenia and Diabetes Anthony P. Weiss*, David C. Henderson, Jeffrey B. Weilburg, Donald C. Goff, James B. Meigs, Enrico Cagliero, Richard W. Grant 137. Aripiprazole Effects in Schizophrenia Patients with High or Low Agitation Britt West*, James Appel, Stephen Marder, Joseph Pultz, Andrei Pikalov, Ronald Marcus, Rolando Gutierrez-Esteinou, David Crandall 138. Anterior Cingulate Bundle Abnormality in Children and Adolescents with Schizophrenia Tonya White*, Ayse T. Karagille, Stephane Leherecy, Mustafa Kendi, Canan Karatekin, Angela Guimaraes, Nicholas Davenport, S. C. Schulz, Kelvin O. Lim 139. Altered Cerebral Processing of Reward Uncertainty in Patients with Schizophrenia While Medication-Free and on Atypical Neuroleptics Dylan Wint*, Jean-Claude Dreher, Daniella Furman, Paul Koch, Philip Kohn, Michael Egan, Daniel Weinberger, Karen F. Berman 140. Asenapine: A Novel Psychotherapeutic Agent with a Unique Human Receptor Binding Signature Mohammed Shahid, Erik Wong*, Glenn B. Walker, Ross A. Baker, Anil S. Jina, Stevin Zorn 141. Variation in Catecol-O-Methyltransferase and GRM3 on Working Memory Load and Prefrontal Cortical Physiology Hao Yang Tan*, Qiang Chen, Steven Sust, Joshua W. Buckholtz, Richard Straub, Venkata S. Mattay, Michael F. Egan, Daniel R. Weinberger, Joseph H. Callicott 152 Posters 2006.qxp 11/17/05 7:46 AM Page 153 Poster Session III—Wednesday 142. Cortisol and Cytokines in Chronic and Treatment-Resistant Patients with Schizophrenia: Association with Psychopathology and Response to Antipsychotics Xiang Y. Zhang*, Dong F. Zhou 143. BDNF Levels and Genotype Are Associated with Antipsychotic-Induced Weight Gain in Patients with Chronic Schizophrenia Xiang Y. Zhang*, Yun L. Tan, Dong F. Zhou 144. Histone Hyper-Acetylation Enhances Memory Storage and Facilitates Synaptic Plasticity via the Transcription Factor CREB Ted Abel*, Chris Vecsey, K. Matthew Lattal, Joel Stein, Sara Fabian, Michelle Attner, Josh Hawk, Marcelo A. Wood 145. Changes in Natural Killer Cell Function, Inflammatory Signaling and Plasma IL-6 Production During Acute Stress in Patients with Major Depression Oyetunde Alagbe*, Thaddeus Pace, Tanya Mletzko, Jerry Vogt, Charles Nemeroff, Christine Heim, Andrew Miller 146. The Phosphodiesterase Type IV Inhibitor, Rolipram, Activates Septohippocampal Neurons Min Wu, Elena Morozova, Iryna Dumalska, Ronald S. Duman, Meenakshi Alreja* 147. Creation of Designer Biogenic Amine Receptors via Directed Molecular Evolution Blaine Armbruster*, Bryan Roth 148. Elevated Membrane Cholesterol Limits Metabotropic Glutamate Receptor (mGluR) Suppression of NMDA Function: A Potential Contribution to Antipsychotic Action? Andrius Baskys*, Liwei Fang, Moti L. Kashyap, Vaijinath Kamanna, Ildar T. Bayazitov 149. Enzymes Coupled with Cyclooxygenase Are Altered in the Brain of Cyclooxygenase-1 Deficient Mice: Implications for Neuroprotection in Neuropsychiatric Disorders Sang-Ho Choi, Francesca Bosetti* 153 Posters 2006.qxp 11/17/05 7:46 AM Page 154 Poster Session III—Wednesday 150. ERK MAP Kinase Signaling in Postmortem Brain of Suicide Subjects: Differential Regulation of Upstream Raf Kinases Raf-1 and B-Raf Yogesh Dwivedi*, Robert Conley, Ghanshyam N. Pandey 151. Adderall® Produces Differential Dopamine Overflow When Compared to D-Amphetamine in Rat Striatum Paul E. Glaser*, B. M. Joyce, Garretson D. Epperly, Greg A. Gerhardt 152. Distinct Roles for MT1 and MT2 Melatonin (MLT) Receptors in MLTMediated Phase Shifts of Circadian Rhythms R. L. Hudson*, I Stepien, P Ginter, M. L. Dubocovich 153. Hippocampal Erk Signalling in Stress-Enhanced Aversive Learning Farahnaz Sananbenesi, Andre Fischer, Christina Schrick, Jelena Radulovic* 154. Mood Stabilizers That Downregulate the Brain Arachidonic Acid Cascade Reduce AP-2 or NF-κB Transcription Factors in Rat Frontal Cortex Jagadeesh S. Rao*, Richard P. Bazinet, Ho-Joo Lee, Stanley I. Rapoport 155. Identification and Characterization of D2 Dopamine Receptor Interacting Proteins David R. Sibley*, Lisa A. Hazelwood, R. B. Free, David M. Cabrera 156. Protein Interactions of the Vesicular Glutamate Transporter, VGLUT1 Susan Voglmaier*, Robert H. Edwards 157. Dexras1 Is a Novel Modulator of Neuronal Adenylyl Cyclases Chau H. Nguyen, Val J. Watts* 158. Long-Term Efficacy of Ziprasidone in Treatment-Refractory Schizophrenia Steven G. Potkin, Antony Loebel*, John Kane, Cynthia Siu 154 Posters 2006.qxp 11/17/05 7:46 AM Page 155 Poster Session III—Wednesday 159. Dopamine and Serotonin Receptor Occupancy of Long Acting Injectable Risperidone in Patients with Schizophrenia Steven G. Potkin*, Jogesh Mukherjee, Georges Gharabawi, Daphne Collins 160. Adult Outcome in Children with Obsessive-Compulsive Disorder Michael H. Bloch*, Britt Craiglow, Philip Dombrowski, Katie Panza, Denis Sukhodolsky, Bradley S. Peterson, James Leckman 161. Regulation of Apolipoprotein L2 in Human Drug Abuse Elin Lehrmann*, Carlo Colantuoni, Thomas M. Hyde, Joel E. Kleinman, Kevin G. Becker, William J. Freed 155 Posters 2006.qxp 11/17/05 7:46 AM Page 156 NMP 2006.qxp 11/17/05 7:47 AM Page 157 NONMEMBER PARTICIPANTS NMP 2006.qxp 11/17/05 7:47 AM Page 158 NMP 2006.qxp 11/17/05 7:47 AM Page 159 Roger Albin Professor of Neurology University of Michigan Health System 200 Zina Pitcher Place Kresge Building 111, Rm. 4412 Ann Arbor, MI 48109-0585 Ruben Baler National Institute of Health/NIDA 6001 Executive Blvd. NSC Bldg., Room 5241 Bethesda, MD 20892 Ben Barres Stanford University School of Medicine 299 Campus Drive Fairchild Bldg., Room D235 Stanford, CA 94305-5125 Paul Andreason FDA-Division of Psychiatry Products Building 22, Room 4112 10903 New Hampshire Avenue Silver Spring, MD 20993-0002 Jill Becker University of Michigan 530 Church Street Ann Arbor, MI 48109 Stewart Anderson Box 244 1300 York Avenue New York, NY 10021 Francesco Benedetti San Raffaele Turro Via Stamira D'Ancona 20 Milano 20127 ITALY Eva Anton University of North Carolina, Chapel Hill 105 Mason Farm Road Neuroscience Center, Room 7109B Chapel Hill, NC 27599 Thomas Biederer Yale University School of Medicine Mol Biophys & Biochem New Haven, CT 06520-8024 Ben Bahr 372 Fairfield Road Unit-2092 Storrs, CT 06269-2092 Michel Bouvier Université De Montréal Département De Biochimie Unive 2900 Edouard Montpetit Montreal, QUE H3C 3J7 CANADA Vaishali Bakshi Wisconsin Psychiatric Institute & Clinics 6001 Research Park Blvd Dept. of Psychiatry Madison, WI 53719 Jan Buitelaar 159 NMP 2006.qxp 11/17/05 7:47 AM Page 160 Andres Buonanno National Institute of Health 35 Lincoln Drive MSC 3713, Bldg 35, Room 2C1000 Bethesda, MD 20892 Jin-chung Chen Jingshan Chen National Institute of Mental Health 9000 Rockville Pike Bldg. 10, Room 4N307 Bethesda, MD 20892 Donald Burns Merck Research Labs WP44C-2, Box 4 Sumneytown Pike West Point, PA 19486 Daniel Clauw University of Michigan School of Medicine Division of Rheumatology Ann Arbor, MI 48109-0723 M. Catheine Bushnell McGill Centre for Research on Pain 3640 University Street Room M/19 Montreal H3A 2B2 CANADA Lisa Conti University of Connecticut Health Center 263 Farmington Avenue Psychiatry, MC 1410 Farmington, CT 06030 Pamela Butler Nathan Kline Institute for Psychiatric Research 140 Old Orangeburg Road Orangeburg, NY 10962 Gabriel Corfas Harvard Medical School Dept of Neurology 300 Longwood Avenue Boston, MA 02115 Patrizia Caldirola Biovitrum Berzeliusveg 8 Stockholm 11276 SWEDEN Rebecca Craft Washington State University Dept. of Psychology P.O. Box 644820 Pullman, WA 99164-4820 Dave Ceryak Eli Lilly and Company Law Division Lilly Corporate Center Indianapolis, IN 46285 John Cryan University College Cork School of Pharmacy Dept of Pharmacology Cork City IRELAND Kiki Chang Stanford University Psychiatry 401 Quarry Road Stanford, CA 94305 160 NMP 2006.qxp 11/17/05 7:47 AM Page 161 Cyril D'Souza Psychiatry Dept 20 York Street New Haven, CT 06510 Lars Farde AstraZeneca R&D Global Discovery Research Area CNS Pain Control Sodertalje SE-15185 SWEDEN Mony De Leon New York University School of Medicine 560 First Avenue New York, NY 10016 Joram Feldon Swiss Federal Institute of Technology Zurich Schorenstrasse 16 Schwerzenbach 8603 SWITZERLAND Michael Dean National Cancer Institute Laboratory of Genomic Diversity Bld. 560, Rm. 21-18 Frederick, MD 21702 Anna Francesconi Albert Einstein College of Medicine Dept of Neuroscience 1300 Morris Park Avenue Bronx, NY 10461 Jing Du National Institute of Mental Health 49 Convent Drive Bldg. 49, Room B1C60 Bethesda, MD 20892 John Gabrieli Stanford University School of Medicine Department of Psychology Jordan Hall Building 420, Room 300 Stanford, CA 94305 Laura Dugan UCSD 9500 Gilman Drive (0665) San Diego, CA 92093 Albert Galaburda 330 Brookline Avenue, KS-274 Boston, MA 02215 Howard Eichenbaum Boston University 2 Cummington Street Boston, MA 02215 S. Gatley 490 Bell Avenue Upton, NY 11973 Christopher Evans NPI 760 Westwood Plaza Psychiatry & Behavioral Sciences Los Angeles, CA 90024-1759 Jay Gingrich New York State Psychiatry Institute Unit 40 1051 Riverside Drive New York, NY 10032 161 NMP 2006.qxp 11/17/05 7:47 AM Page 162 Richard Glass JAMA 1033 E 49th Street Chicago, IL 60615 Chang-Gyu Hahn 415 Curie Blvd 545 CRB Philadelphia, PA 19014 Paul Glimcher New York University 4 Washington Place Room 809 New York, NY 10003 Maureen Hahn Instructor Vanderbilt University Medical Center 465 21st Avenue South 7141 MRB III Nashville, TN 37232 Steven Goldberg National Institute on Drug Abuse 5500 Nathan Shock Drive Preclinical Pharmacology Baltimore, MD 21224 Ronald Hammer Tufts University School of Medicine 750 Washington Street Box 1007 Boston, MA 02111 James E. Goldman Professor of Pathology and Director, Division of Neuropathology Columbia University College of P&S 630 West 168th Street, P&S 15-420 New York, NY 10032 Stephan Heckers McLean Hospital 115 Mill Street Schizophrenia & Bipolar Disease Belmont, MA 02478 Guy Goodwin Oxford University Warneford Hospital Lane Oxford OX3 7JX UNITED KINGDOM Markus Heilig National Institute of Health/NIAAA 10 Center Drive 10-CRC/15330 Bethesda, MD 20892-1610 Todd Gould National Institute of Mental Health Bldg. 35, Room 1C-912 9000 Rockville Pike Bethesda, MD 20892-3711 Fred Helmstetter University of Wisconsin Dept of Psychology P.O. Box 413 Milwaukee, WI 53201 Heinz Grunze Department of Psychiatry, LMU Nussbaumastrasse 7 Munich 80336 GERMANY Bart Hoebel Princeton University Department of Psychology Princeton, NJ 08544 162 NMP 2006.qxp 11/17/05 7:47 AM Page 163 William Horan UCLA Dept of Psychiatry & Biobehavioral Science 300 UCLA Medical Plaza, Suite 2240 Los Angeles, CA 90095 Kwang-Soo Kim McLean Hospital/Harvard Medical School 115 Mill Street Belmont, MA 02478 Becky Kinkead Emory University School of Medicine 101 Woodruff Circle Suite 4000 WMRB Atlanta, GA 30322 Z. Huang Beckman 220 One Bungtown Road Cold Spring Harbor, NY 11724 Richard Huganir Johns Hopkins University School of Medicine Dept of Neuroscience 725 Wolfe Street, PCTB 904A Baltimore, MD 21205 Peter Klein 415 Curie Blvd 364 Clinical Research Bldg Philadelphia, PA 19104-6140 Cary Lai Scripps Research Institute 10550 N. Torrey Pines Road La Jolla, CA 92037 Sandra Johnson St. Louis University 3700 Lindell Blvd. Saint Louis, MO 63108 Ruth Lanius University of Western Ontario 339 Windermere Road, P.O. Box 5339 Room 10N07 London, Ontario N6A 5A5 CANADA Julie Kauer Brown University Biomedical Center, Department of MPPB PO Box G-B4 Providence, RI 02912 Amanda Law University of Oxford Warneford Hospital, Headington Dept. of Psychiatry Oxford UNITED KINGDOM Hans Keirstead University of California, Irvine 2111 Gillespie Neuroscience Facility Irvine, CA 92697 Terence Ketter Stanford University School of Medicine Department of Psychiatry Room 2124 401 Quarry Road Stanford, CA 94305-5723 Ellen Leibenluft National Institute of Mental Health, NIH Mood & Anxiety Program Bldg. 15K, MSC 2670 Bethesda, MD 20892-2670 163 NMP 2006.qxp 11/17/05 7:47 AM Page 164 Sarah Leibowitz The Rockefeller University 1230 York Avenue New York, NY 10021 John Littleton University of Kentucky Cooper and University Drive Lexington, KY 40546 Vance Lemmon University of Miami Medical School Lois Pope LIFE Center, Room 4-16 1095 NW 14th Terrace Miami, FL 33136 David Lyons Stanford University 1201 Welch Rd Psychiatry, MSLS, Room 104 Stanford, CA 94305 Anne Lesage Johnson & Johnson Pharmaceutical R&D Turnhoutseweg 30 CNS Discovery Research Beerse B2340 BELGIUM Pierre Magistretti Director, Center for Psychiatric Neuroscience Department of Psychiatry - CHUV and University of Lausanne (UNIL), Medical School Professor of Neuroscience Brain and Mind Institute Ecole Polytechnique Federale Lausanne (EPFL) Rue du Bugnon 7, CH-1005 Lausanne SWITZERLAND Lydia Lewis The Depression and Bipolar Support Alliance 730 N Franklin Suite 501 Chicago, IL 60610 Steven Maier University of Colorado Psychology Campus Box 345 Boulder, CO 80309 Shon Lewis G.907 Stopford Building Oxford Road Manchester M13 9PT UNITED KINGDOM Robert Malison Yale School of Medicine Clinical Neuroscience Research Unit 34 Park Street New Haven, CT 06519 Raye Litten National Institute on Alcohol Abuse & Alcoholism 5635 Fishers Lane Room 2041 Bethesda, MD 20892-9304 Shaila Mani Baylor School of Medicine One Baylor Plaza 123D Houston, TX 77030 164 NMP 2006.qxp 11/17/05 7:47 AM Page 165 Kelsey Martin UCLA, Brain Research Institute, Gonda Bldg. Department of Psychiatry 695 Charles Young Drive South Los Angeles, CA 90095-1761 David Meltzer University of Chicago 5841 S Maryland MC 2007 Chicago, IL 60637 Graeme Milligan University of Glasgow Davidson Building University Avenue Glasgow G12 8QQ UNITED KINGDOM Emeran Mayer UCLA/GLA VA HS Bldg 115/Room 223 11301 Wilshire Blvd Los Angeles, CA 90073 Susan McConnell Stanford University Herrin Labs 115 385 Serra Mall Stanford, CA 94305-5020 Pendleton Montague Baylor College of Medicine Center for Theoretical Neuroscience Division of Neuroscience 1 Baylor Plaza Houston, TX 77030 Joseph McEvoy Duke University Medical Center/John Umstead Hospital 1003 12th Street Bldg. 32 Butner, NC 27509 Anne Murphy Center for Behavioral Neuroscience P.O. Box 4010 Atlanta, GA 30302 Jaap Murre Roeterstraat 15 Amsterdam 1018 NETHERLANDS Ronald McKay NINDS, Laboratory of Molecular Biology Porter Neurosciences Research Center Building 35, Room 3A-201 35 Covent Drive, MSC 3703 Bethesda, MD 20892-4157 Robert Muse Stein, Mitchell & Mezines 1100 Connecticut Avenue, NW Suite 1100 Washington, DC 20036 Michael Meaney Douglas Hospital Research Center 6875 LaSalle Blvd Montreal, Quebec H4H 1R3 CANADA Vincent Mutel Addex Pharmaceuticals, Ltd. 12, Chemin Des Aulx Plan Les Ouates CH-1228 SWITZERLAND 165 NMP 2006.qxp 11/17/05 7:47 AM Page 166 Toshitaka Nabeshima Professor & Director Nagoya University Graduate School of Medicine Dept of Neuropsychopharmacol & Hosp Phar 65 Touruma-cho, Showa-Ku Nagoya 486-8560 JAPAN Paul Patterson California Institute of Technology Div Biol 216-76 Pasadena, CA 91125 Jane Pearson Assoc Dir Preventive Interventions NIMH Div of Services & Intervention Research 6001 Executive Blvd, Rm 7160 MSC 9635 Bethesda, MD 20892-9635 Ann Neale 60 Stone Pine Road Suite 200 Half Moon Bay, CA 94019 Laura Peoples University of Pennsylvania Department of Psychology 3720 Walnut Street Philadelphia, PA 19104-6196 David Nelson Eli Lilly and Company Lilly Corporate Center Drop Code 0510 Indianapolis, IN 46285 Srinivasan Pillay McLean Hospital 115 Mill Street Brain Imaging Center Belmont, MA 02478 Raymond Niaura Brown Medical School 345 Blackstone Blvd. Psychiatry Providence, RI 02906 Diego Pizzagalli Harvard University Dept of Psychology 1220 William James Hall 33 Kirkland Street Cambridge, MA 02138 David Nutt University of Bristol Psychopharmacology Unit Whitson Street Bristol BS1 3NY UNITED KINGDOM Jonathan Pollock National Institute on Drug Abuse Division of Neuroscience & Behavioral Research 6001 Executive Blvd., Room 4282 MCS9555 Bethesda, MD 20892-9555 Valerie Olson Acting Assistant Professor University of Washington VA Puget Sound Health Care System Dept of Psychiatry & Behavioral Science 1660 S. Columbia Way Seattle, WA 98108 166 NMP 2006.qxp 11/17/05 7:47 AM Page 167 Maurizio Popoli University of Milano Center of Neuropharmacology Dept. of Pharmacology Sci., Via Balza Milano 20133 ITALY Donald Rosenstein Office of the Clinical Director National Institute of Mental Health Bldg 10-CRC, Room 6-5340 10 Center Drive Bethesda, MD 20892 Richard Porter Hoffmann La Roche Bldg. 69-452 Basel SWITZERLAND Barbara Rothbaum Emory University School of Medicine Psychiatry, The Emory Clinic 1365 Clifton Road Atlanta, GA 30322 A. Redish University of Minnesota 6-145 Jackson Hall 321 Church Street Minneapolis, MN 55455 Barbara Sahakian University of Cambridge School of Clinical Medicine Department of Psychiatry, Box 189 Audenbrookes Hospital Cambridge, Eng CB22QQ UNITED KINGDOM Victoria Risbrough University of California, San Diego 9500 Gilman Drive Psychiatry MC0804 La Jolla, CA 92093 Larry Scahill Yale Child Study Center 230 South Frontage Road P O Box 207900 New Haven, CT 06520-7900 Angela Roberts University of Cambridge Dept. of Anatomy Downing Street Cambridge CB2 3DY UNITED KINGDOM Peter Scheiffele Columbia University Dept of Physiol & Cell Biophys 630 West 168th St P&S 11-511, MC22 New York, NY 10032 Robert Rosenheck VA Connecticut Healthcare System NEPEC #182, Bldg. 8 950 Campbell Avenue West Haven, CT 06516 Yavin Shaham IRP/NIDA 5500 Nathan Shock Drive Baltimore, MD 21044 167 NMP 2006.qxp 11/17/05 7:47 AM Page 168 Philip Shaw National Institute of Mental Health 10 Center Drive, MSC 1600 Bldg. 10, Room 3N202 Bethesda, MD 20892 Dietrich Stephan The Translational Genomics Research Institute 445 North Fifth Street Phoenix, AZ 85004 Saul Shiffman Smoking Research Group 130 N. Bellefield Avenue Suite 510 Pittsburgh, PA 15213 David Talmage Columbia University Institute of Human Nutrition 701 W 168th Street New York, NY 10032 David Silbersweig Weill Medical College of Cornell Univ. New York Presbyterian Hospital 1300 York Avenue Box 140, Room F1303 New York, NY 10021 Todd Thiele University of North Carolina Dept. of Psychology CB 3270 Chapel Hill, NC 27599 Steven Thomas University of Pennsylvania 3620 Hamilton Walk 103 John Morgan Bldg. Philadelphia, PA 19104-6084 Rajita Sinha Yale University School of Medicine 34 Park Street Room S110 New Haven, CT 06519 Andrea Tone Professor & Director of Graduate Studies McGill University 3647 Peel Street Faculty of Medicine Montreal H3A 1X1 CANADA Rainier Spanagel J5 Mannheim 68159 GERMANY Thomas Spencer Massachusetts General Hospital 55 Fruit Street YAW 6900 Boston, MA 02114 Bruce Trapp Cleveland Clinic 9500 Euclid Avenue Dept. of Neuroscience NC30 Cleveland, OH 44195 Lalit Srivastava McGill University Verdun, Quebec H4H 1R3 CANADA 168 NMP 2006.qxp 11/17/05 7:47 AM Page 169 Hiroshi Ujike Okayama Graduate School of Medicine 2-5-1 Shikata-cho Okayama 700-8558 JAPAN John Walkup Johns Hopkins Hospital CMSC 314 600 N. Wolfe Street Baltimore, MD 21287-3325 Leslie Ungerleider National Institute of Mental Health 10 Center Drive Bldg. 10, MSC-1366 Bethesda, MD 20892-1366 Stephen Warren Emory University School of Medicine Dept of Human Genetics Atlanta, GA 30322 Cynthia Weickert National Institute of Mental Health 10 Center Drive Bldg. 10, Room 3N234 Bethesda, MD 20892-1276 Maarten Van Den Buuse Mental Health Research Institute Behavioral Neuroscience Laboratory 155 Oak Street Parkville 3052 AUSTRALIA David Weinshenker Assistant Professor Emory University Whitehead Building, Suite 301 615 Michael Street Atlanta, GA 30322 Marquis Vawter University of California, Irvine Gillespie, Room 2119 Irvine, CA 92697-1675 Eduard Vieta University of Barcelona, Hospital Clinic Villarroel 170, Rossello 140 Barcelona, NJ 08036 SPAIN Franz Vollenweider University Hospital of Psychiatry University of Zurich Lenggstrasse 31 PO Box 68 Zurich CH-8032 SWITZERLAND Lois Winsky National Institute of Mental Health Division of Neurosci MSC 9641 Room 7184 6001 Executive Blvd Bethseda, MD 20892-9641 Ruth Wood Keck of Medicine of USC 1333 San Pablo Street BMT 408A Los Angeles, CA 90033 169 NMP 2006.qxp 11/17/05 7:47 AM Page 170 James Woodgett Princess Margaret Hospital 610 University Avenue 10th Floor, Room 622 Toronto, ON M5G 2M9 CANADA Kiyofumi Yamada Kanazawa University Graduate School of Natural Science Kakuma-Machi Kanazawa JAPAN Larry Young Associate Professor Emory University Dept. of Psychiatry Yerkes Research Center 954 Gatewood Road Atlanta, GA 30322 James Zacny University of Chicago 5841 S. Maryland Avenue MC4028 Chicago, IL 60637 Sidney Zisook University of California, San Diego 9500 Gilman Drive 0603R La Jolla, CA 92093 170 Appendix 2006.qxp 11/17/05 7:48 AM Page 171 APPENDIX Appendix 2006.qxp 11/17/05 7:48 AM Page 172 Appendix 2006.qxp 11/17/05 7:48 AM Page 173 Disclosure Statement It is the policy of Vanderbilt University School of Medicine that the information presented at Vanderbilt CME activities will be unbiased and based on scientific evidence. To help readers of this enduring material make judgments about the presence of bias, disclosure of the financial relationships of speakers and Vanderbilt with commercial entities that produce or market products or services related to the content of this CME activity, if any, are listed below: Anissa Abi-Dargham Honorarium: Bristol-Myers Squibb, Otsuka, Sanofi-Aventis Grant/Research Support: Bristol-Myers Squibb Steven Arnold Consultant: Esai, Merck Gary Aston-Jones Consultant: Sanofi Aventis Speaker’s Bureau: Sanofi Aventis Mark Bear Consultant: Seaside Therapeutics Hilary Blumberg Honorarium: Abbott, Lilly Theresa Branchek Stock Shareholder: Lundbeck Jan Buitelaar Honorarium: Eli Lilly, Janssen Cilag BV Consultant: Abbott, Eli Lilly, Janssen Cilag BV, Medice, Shire William Bunney, Jr. Consultant: Thuris Corporation Stock Shareholder: Thuris Corporation H. Donald Burns Stock Shareholder: Merck Other, Employee: Merck 173 Appendix 2006.qxp 11/17/05 7:48 AM Page 174 William Carpenter Consultant: Janssen, Pfizer, Solvay, Wyeth Dave Ceryak Stock Shareholder: Eli Lilly and Company Other, Employee: Eli Lilly and Company Kiki Chang Honorarium: Abbott Labs, AstraZeneca, GlaxoSmithKline, Lilly, Shire US Grant/Research Support: Abbott Labs, AstraZeneca, GlaxoSmithKline, Otsuka Pharmaceuticals Consultant: Abbott Labs, AstraZeneca, GlaxoSmithKline, Lilly, Shire US Daniel Clauw Consultant: Cypress Biosciences Stock Shareholder: Cypress Biosciences John F. Cryan Other, Employee: Novartis Pharma AG John Csernansky Honorarium: Bristol-Myers Squibb, Janssen Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Forest Pharmaceuticals, Pfizer Consultant: Aventis Sanofi Mony de Leon Grant/Research Support: Forest Labs, Janssen Ariel Deutch Grant/Research Support: Eli Lilly, Pfizer Consultant: Eli Lilly Speaker’s Bureau: Eli Lilly Margarita Dubocovich Honorarium: Pfizer Consultant: Shire Pharmaceuticals Group Lars Farde Stock Shareholder: AstraZeneca 174 Appendix 2006.qxp 11/17/05 7:48 AM Page 175 Colin Fish Stock Shareholder: GlaxoSmithKline Other, Employee: GlaxoSmithKline Richard Frank Other, Employee: GE Healthcare Paul Gaylo Stock Shareholder: Eli Lilly & Company Other, Employee: Eli Lilly & Company Mark Geyer Consultant: Abbott, Acadia, Addex, Avera, Cenomed, Lilly, Nura, Repligen, Serono, Solvay, Vertex Grant/Research Support: GlaxoSmithKline, Repligen Stock Shareholder: San Diego Instruments Richard Glass Other, Employee: Deputy Editor of JAMA, American Medical Association Alexander Glassman Consultant: AstraZeneca, GlaxoSmithKline, Lilly, Ono Pharma, Pfizer Speaker’s Bureau: AstraZeneca, GlaxoSmithKline, Pfizer Ira Glick Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Lilly, Pfizer, Shire, Solvay Consultant: AstraZeneca, Bristol-Myers Squibb, Lilly, Pfizer Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Janssen, Lilly, Pfizer Stock Shareholder: Janssen Guy Goodwin Honorarium: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Lilly, Lundbeck, Sanofi-Aventis Grant/Research Support: Sanofi-Aventis, Servier Consultant: Bristol-Myers Squibb, GlaxoSmithKline, Sanofi-Aventis, Servier, Wyeth 175 Appendix 2006.qxp 11/17/05 7:48 AM Page 176 Anthony Grace Consultant: Novartis, Servier, Taisho Heinz Grunze Grant/Research Support: Novartis Germany, UCB Belgium Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Pfizer Ruben Gur Grant/Research Support: Merck Consultant: Brain Resource Center Sydney, CogTest LTD London, Eli Lilly Chang-Gyu Hahn Consultant: Pfizer Pharmaceuticals Richard Huganir Consultant: Intra-cellular Therapeutics Inc, Saegis Other, Royalties: Upstate Biotechnology Jonathan Javitch Consultant: Novasite Pharmaceuticals Dilip Jeste Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Solvay, Wyeth Grant/Research Support: Janssen Ned Kalin Grant/Research Support: Dana Foundation, NIH, Stanley Foundation Consultant: Bristol-Myers Squibb, Corcept, Cyberonics, Cypress, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica, Neurocrine Inc, Novartis, Otsuka America Pharmaceutical Inc, Sanofi-Synthelabo, Somerset Pharmaceuticals, Wyeth Pharmaceuticals Speaker’s Bureau: Janssen Pharmaceuticals, Wyeth Pharmaceuticals Stock Shareholder: Corcept, Neurocrine Inc. Other, Owner: Promoter Neurosciences, LLC Shitij Kapur Grant/Research Support: AstraZeneca, Eli Lilly, EMD, Janssen, Neuromolecul Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gla Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Gla 176 Appendix 2006.qxp 11/17/05 7:48 AM Page 177 Ira Katz Grant/Research Support: Janssen Consultant: AstraZeneca, Janssen, Lilly John Kelsoe Speaker’s Bureau: GlaxoSmithKline Stock Shareholder: Psynomics, Inc. James Kennedy Consultant: GlaxoSmithKline Terrence Ketter Honorarium: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eli Lilly & Company, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals Corporation, Pfizer, Shire Pharmaceuticals Group Grant/Research Support: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Eisai, Elan Pharmaceuticals, Eli Lilly & Company, GlaxoSmithKline, Janssen Pharmaceutica Products, Novartis Pharmaceuticals Corporation, Shire Pharmaceuticals Group, Solvay Pharmaceuticals, Wyeth Pharmaceuticals Consultant: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Cephalon Inc, Corcept Therapeutics, Elan Pharmaceuticals, Eli Lilly & Company, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica Products, Jazz Pharmaceuticals, Novartis Pharmaceuticals Corporation, Pfizer, Shire Pharmaceuticals Group, Solvay Pharmaceuticals, UCB Pharmaceuticals, Wyeth Pharmaceuticals Becky Kinkead Grant/Research Support: Bristol-Myers-Squibb, Merck, NIMH, Pfizer Pharmaceuticals, Solvay Donald Klein Consultant: Vela Pharmaceutical, Vivometrics Hartmuth Kolb Other, Employee: Siemens Molecular Imaging George Koob Consultant: Alkermes, Forest Laboratories, Merck/Lipha 177 Appendix 2006.qxp 11/17/05 7:48 AM Page 178 Anne Lesage Other, Employee: Johnson&Johnson Pharmaceutical R & D David Lewis Grant/Research Support: Lilly, Merck, Pfizer Consultant: Lilly, Merck, Pfizer Shon Lewis Honorarium: Astra Zenica, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Lilly, Lundbeck, Novartis, Pfizer, Wyeth Alfred Lewy Other, Patents: OHSU Jeffrey Lieberman Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer Other, Advisory Board: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Pfizer John Littleton Honorarium: Forest Laboratories Grant/Research Support: Merck s.a. Consultant: Forest Laboratories, Merck s.a. Speaker’s Bureau: Forest Laboratories Stock Shareholder: Naprogenix Inc Athina Markou Grant/Research Support: Novartis Barbara Mason Consultant: Forest, Somaxon Speaker’s Bureau: Forest Other, Medication Supply: Pfizer Pharmaceuticals Emeran Mayer Consultant: Allergan, Amgen, AstraZeneca, Avera, GSK, Lilly Consultant: J&J, Merck, Novartis, Solvay Grant/Research Support: Novartis, GSK, Lilly 178 Appendix 2006.qxp 11/17/05 7:48 AM Page 179 Christopher McDougle Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Co, Janssen Pharmaceutica, PediaMed Consultant: Bristol-Myers Squibb, Eli Lilly and Co, Janssen Pharmaceutica, PediaMed Speaker’s Bureau: Bristol-Myers Squibb, Janssen Pharmaceutica Joseph McEvoy Honorarium: AstraZeneca, Bristol-Myers, Janssen, Lilly, Pfizer Grant/Research Support: AstraZeneca, Bristol-Myers, Janssen, Lilly, Pfizer David Meltzer Grant/Research Support: Merck Roger Meyer Grant/Research Support: Forest, Sepracor, Star Scientific Consultant: Best Practice Management Inc., Cephalon, Memory Pharmaceuticals, NABI, Neurim, Ovation, Sanofi, Sepracor, Solvay, Star Scientific Stock Shareholder: Best Practice Management Inc Other, Company Contract: Abbott Pharmaceuticals, AstraZeneca, BristolMyers Squibb, DAS, GlaxoSmithKline, Janssen, J & J Research, Eli Lilly, M’s Science, Novartis, Pfizer, Prestwick Pharmaceuticals, Takeda Graeme Milligan Grant/Research Support: Cara Therapeutics, Pfizer Consultant: Amersham Biosciences, Boehringer Ingelheim, Cara Therapeutics, Novasite Pharmaceuticals John Morris Grant/Research Support: Elan, Wyeth Consultant: Amgen, Axonyx, Bristol-MyersSquibb, Elan, Forest Labs, GlaxoSmithKline, Johnson & Johnson, Neurochem, Novartis, SanofiAventis Speaker’s Bureau: Forest Labs Ann Neale Other, Employee: Saegis Pharmaceuticals David Nelson Other, Employee: Eli Lilly and Company 179 Appendix 2006.qxp 11/17/05 7:48 AM Page 180 Charles Nemeroff Grant/Research Support: Abbott Laboratories; AFSP; AstraZeneca; BristolMyers-Squibb; Forest Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; NARSAD; NIMH; Pfizer Pharmaceuticals; Stanley Foundation/NAMI; Wyeth-Ayerst Consultant: Abbott Laboratories; Acadia Pharmaceuticals; Bristol-MyersSquibb; Corcept; Cypress Biosciences; Cyberonics; Forest Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; Otsuka; Pfizer Pharmaceuticals; Quintiles; Wyeth-Ayerst Speaker’s Bureau: Abbott Laboratories; GlaxoSmithKline; Janssen Pharmaceutica; Pfizer Pharmaceuticals Stock Shareholder: Corcept; Cypress Biosciences; Neurocrine Biosciences; Acadia Pharmaceuticals Other, Board of Directors: American Foundation for Suicide Prevention (AFSP); American Psychiatric Institute for Research and Education (APIRE); George West Mental Health Foundation; Novadel Pharmaceuticals Other, Equity: Reevax; BMC-JR LLC; CeNeRx Other, Patents: method and devices for transdermal delivery of lithium (US 6,375,990 B1); method to estimate serotonin and norepinephrine transporter occupancy after drug treatment using patient or animal serum (provisional filing April, 2001) Raymond Niaura Consultant: GlaxoSmithKline David J. Nutt Grant/Research Support: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Consultant: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Speaker’s Bureau: AstraZeneca, GlaxoSmithKline, Janssen, Merck Sharp & Dohme, Organon, Wyeth Stock Shareholder: GlaxoSmithKline Charles O'Brien Grant/Research Support: Pfizer Consultant: Alkermes, Forest, McNeil Steven Paul Stock Shareholder: Eli Lilly & Company Other, Employee: Eli Lilly & Company 180 Appendix 2006.qxp 11/17/05 7:48 AM Page 181 Richard Porter Grant/Research Support: Roche Other, Employee: Roche William Potter Other, Employee: Merck Research Labs Mark Rasenick Grant/Research Support: Genzyme, NIH, Pfizer Murray Raskind Consultant: Bristol-Myers Squibb, Forest Laboratories, Ortho-McNeil Neurologics Speaker’s Bureau: Bristol-Myers Squibb, Forest Laboratories, Ortho-McNeil Neurologics Trevor Robbins Honorarium: Lundbeck, Pfizer, Roche Grant/Research Support: Cephalon, Merck Sharp & Dohme Consultant: Cambrideg Cognition, Eli Lilly Speaker’s Bureau: Lundbeck, Pfizer, Roche Stock Shareholder: CENES plc Robert Rosenheck Honorarium: Janssen Consultant: Bristol Myers Squibb Barbara Rothbaum Stock Shareholder: Virtually Better Barbara Sahakian Consultant: Cambridge Cognition Ltd (UK) Lawrence Scahill Consultant: Bristol-Myers Squibb, Janssen, Pfizer 181 Appendix 2006.qxp 11/17/05 7:48 AM Page 182 Alan Schatzberg Honorarium: Lilly Grant/Research Support: Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Somerset, Wyeth Consultant: Abbott, Aventis, BrainCells, Bristol-Myers Squibb, Corcept, Eli Lilly, Forest Labs, GlaxoSmithKline, Innapharma, Janssen, Neuronetics, Organon, Pfizer, Somerset, Somaxon, Wyeth Speaker’s Bureau: Abbott, Aventis, BrainCells, Bristol-Myers Squibb, Corcept, Eli Lilly, Forest Labs, GlaxoSmithKline, Innapharma, Janssen, Neuronetics, Organon, Pfizer, Somerset, Somaxon, Wyeth Other, Equity: BrainCells, Corcept, Elan, Merck, Organon, Pfizer, Somaxon Lon Schneider Grant/Research Support: Bristol-Myers Squibb, Janssen, Pfizer Consultant: AstraZeneca, Bristol-Myers Squibb, Janssen, Pfizer Saul Shiffman Consultant: GlaxoSmithKline Inc Other, Ownership: Invivodata, inc Gary Small Other, Patent: FDDNP-PET: Siemens Thomas Spencer Honorarium: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Grant/Research: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Consultant: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Speaker’s Bureau: Eli Lilly & Co, Janssen Pharmaceutical, McNeil Pharmaceutical, Novartis Pharmaceutical, Shire Laboratories Stephen Strakowski Grant/Research Support: AstraZeneca, Forest, Janssen, Lilly Consultant: OMP, Pfizer Speaker’s Bureau: AstraZeneca, Bristol-Myers Squibb, Forest, Janssen, Lilly, OMP, Pfizer Trey Sunderland Honorarium: Lundbeck, Pfizer Consultant: AstraZeneca, Pfizer 182 Appendix 2006.qxp 11/17/05 7:48 AM Page 183 Robert Swift Grant/Research Support: Bristol-Myers Squibb, Forest Laboratories, OrthoMcNeil, Pfizer Inc Consultant: Alkermes, Forest Laboratories, Pfizer Inc Speaker’s Bureau: Forest Laboratories Pierre Tariot Grant/Research Support: AstraZeneca, Forest, Janssen, Lilly, Pfizer Consultant: AstraZeneca, Forest, Lilly, Pfizer Speaker’s Bureau: AstraZeneca, Forest, Pfizer Eduard Vieta Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag Consultant: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen-Cilag John Walkup Grant/Research Support: Abbott, Lilly, Pfizer Consultant: Lilly Speaker’s Bureau: Janssen, Lilly, Pfizer Stephen Warren Other, Chair, SAB: Seaside Therapeutics Dean Wong Grant/Research Support: Acadia, Eli Lilly, Janssen, McNeil, Merck, Pfizer, Phillip Morris Consultant: AstraZeneca, Aventis, Eli Lilly, Janssen, McNeil, Merck, Pfizer, Pharmacia, Sumitomo 183 Appendix 2006.qxp 11/17/05 7:48 AM Page 184 The following individuals had nothing to disclose: Caleb M. Adler Roger Albin Susan Andersen Stewart A. Anderson Paul Andreason Eva S. Anton Ben A. Bahr Vaishali P. Bakshi Ruben Baler Ben Barres Jill B. Becker Francesco Benedetti Karen Berman Thomas Biederer Randy Blakely Michel Bouvier Linda Brady David Brent Andres Buonanno M. Catherine Bushnell Pamela D. Butler Joseph Buxbaum Patrizia Caldirola Marc G. Caron Cameron S. Carter Dennis Charney Jin-Chung Chen Jingshan Chen Jonathan D. Cohen Lisa H. Conti Gabriel Corfas Rebecca Craft Joseph F. Cubells David J. Cutler Deepak Cyril D'Souza Kenneth Davis Michael Davis Michael Dean Melissa P. DelBello Edward Domino Daniel Dorsa Jing Du Laura L. Dugan Howard Eichenbaum Ezekiel Emanuel Susan Essock Christopher Evans Joram Feldon Anna Francesconi Ellen Frank John Gabrieli Albert Galaburda Samuel John Gatley Elliot S. Gershon John H. Gilmore Jay Gingrich Paul W. Glimcher Steven R. Goldberg Terry Goldberg David Goldman James Goldman Jack M. Gorman Todd Gould Steven Grant Michael F. Green Maureen K. Hahn Ronald P. Hammer James Harris Stephan Heckers Markus Heilig Fred J. Helmstetter James Dee Higley Bartley G. Hoebel William Horan Z. Josh Huang Robert Innis Daniel C. Javitt Sandra H. Johnson Peter Kalivas Julie A. Kauer Hans Keirstead Kwang-Soo Kim Peter S. Klein George F. Koob 184 Appendix 2006.qxp 11/17/05 7:48 AM Page 185 The following individuals had nothing to disclose: Thomas Kosten John Harrison Krystal Cary Lai Ruth Lanius Amanda Jayne Law Ellen Leibenluft Sarah Leibowitz Vance Lemmon Pat Levitt Michael Lewis Barbara K. Lipska Raye Litten Edythe D. London David M. Lyons Pierre Magistretti Steven Maier Alexandros Makriyannis Robert Malenka Robert Malison Shaila Mani Husseini Manji Kelsey Martin Susan K. McConnell Ronald McKay Andreas Meyer-Lindenberg Read Montague Anne Z. Murphy Jaap Murre Vincent Mutel Toshitaka Nabeshima John F. Neumaier Patricio O'Donnell Valerie Olson Paul H. Patterson Jane Pearson Laura Peoples Srinivasan S. Pillay Daniel Pine Diego A. Pizzagalli Jonathan Pollock Maurizio Popoli Gregory J. Quirk Judith L. Rapoport Scott L. Rauch A. David Redish Elliott Richelson Victoria Risbrough Angela Roberts Terry Robinson Lorna Role Donald Rosenstein Bryan L. Roth Peter Scheiffele Peter Schmidt Yavin Shaham Philip Shaw Anantha Shekhar Larry J. Siever David Silbersweig Rajita Sinha Rainer Spanagel Lalit Srivastava Dietrich Stephan Jamie Talan David A. Talmage Todd E. Thiele Steven A. Thomas Andrea Tone Bruce Trapp Hiroshi Ujike Leslie G. Ungerleider Maarten van den Buuse Marquis Vawter Frank Vocci Nora Volkow Franz X. Vollenweider Mark von Zastrow Cynthia Shannon Weickert Daniel R. Weinberger David Weinshenker Friedbert Weiss Susan Weiss Lois Winsky Ruth I. Wood 185 Appendix 2006.qxp 11/17/05 7:48 AM Page 186 The following individuals had nothing to disclose: Jim Woodgett Kiyofumi Yamada Rachel Yehuda Larry James Young James P. Zacny George S. Zubenko Jon-Kar Zubieta 186 Appendix 2006.qxp 11/17/05 7:48 AM Page 187 The following participants intend to discuss an unapproved/investigative (“off-label”) use of a product: Susan Andersen Paul Andreason Steven Arnold Ruben Baler William Bunney, Jr. H. Donald Burns M. Catherine Bushnell Joseph Buxbaum William Carpenter Dave Ceryak Kiki Chang Joseph F. Cubells Michael Dean Edward Domino Ezekiel Emanuel Susan Essock Lars Farde Colin Fish Richard Frank Paul Gaylo Ira Glick Guy M. Goodwin Anthony Grace Steven Grant Michael F. Green Heinz Grunze Markus Heilig Jonathan Javitch Dilip V. Jeste Ned Kalin Peter Kalivas Ira Katz Hans Keirstead Terrence Ketter Donald Klein Hartmuth Kolb Thomas Kosten John Krystal Raye Litten Antony Loebel Husseini Manji Athina Markou Barbara J. Mason Christopher J. McDougle Joseph McEvoy Ann C. Neale David Nutt Charles O’Brien Jane Pearson Daniel Pine Jonathan Pollock Murray Raskind Trevor W. Robbins Donald Rosenstein Barbara Rothbaum Barbara Sahakian Alan Schatzberg Peter Schmidt Lon S. Schneider Larry J. Siever Thomas J. Spencer Stephen Strakowski Robert Swift Pierre N. Tariot Frank Vocci John T. Walkup Daniel R. Weinberger Dean F. Wong 187 Appendix 2006.qxp 11/17/05 7:48 AM Page 188 Author Index 11/17/05 7:49 AM Page 189 AUTHOR INDEX Author Index 11/17/05 7:49 AM Page 190 Author Index 11/17/05 7:49 AM Abadia, Maria Castillo Abel, Ted 153 Abelson, James L. Abi-Dargham, A. Abi-Dargham, Anissa 129 Acharya, Nayan V. Ackenheil, Manfred Adams, David Adams, John Addicott, M.A. Addington, Anjene Addington, Stephanie Adinoff, Bryon Adler, Cal Adler, Caleb Adler, Caleb M. Afari, Niloo Aghajanian, George K. Ahlbrand, Rebecca Ahmed, Saeed Ajilore, Olu Akbar, Natkai Akbarian, Schahram Akil, Huda 145 Akpor-Mensah, Rostian Alagbe, Oyetunde Albers, Lawrence Albin, Roger Alce, Guilna Alexopoulos, George Alia-Klein, Nelly Allen, D. Radant Allen, Albert J. Allen, Lesley A. Allen, Nick Almasy, Laura Alonso, Angelique Alonso, Richard Alper, Kenneth Alpert, Jonathan E. Alphs, Larry Alreja, Meenakshi Page 191 122 24, 126, Altar, C. Altar, C. A. Alvarez, E. Amato, David Ameli, Rezvan Amiel, Jonathan M. Amsterdam, Jay D. Anagnostou, Evdokia Anand, Amit Andersen, Susan L. Anderson, Berry Anderson, Carl M. Anderson, George Anderson, George M. Anderson, Stewart Anderson, Susan Andreason, Paul Andrews, Glenn D. Anggadiredja, K. Angstadt, Michael Angstadt, Mike Ansorge, Mark S. Anthony, James C. Anton, Eva Appel, James Apud, J. Apud, Jose A. Arango, Celso Arango, Victoria Arce, Estibaliz Archer, Stephen Arciniegas, David B. Ardekani, Babak A. Arias, Robert Ariely, Dan Armbruster, Blaine Armitage, Roseanne Arnold, Paul Arnold, Paul D. Arnold, Steven Arolt, Volker Arora, Sanjay Arrillaga-Romany, I. C. Artaloytia, J. F. Artymyshyn, Roman P. 106 118 68, 128, 95 109 99, 128 94 106 124 143 91 117, 144 56 94, 126 143 129 135 122 94 116 99 93, 97, 101 153 148 66 116, 138 94 111 147 108 98 138 105 99 121 107 93 100 153 191 24 100, 135 141 97 146 137 142 114, 115 116 91, 141 104 134 145 114 32 97 38, 49 108 137 108 137 98 91 82 152 151 116 100 139 139 122 139 134 90 117 153 94 27 95 82 98 109 100 100 96 Author Index 11/17/05 7:49 AM Asberg, Marie Ascher-Svanum, Haya 103, 128 Aschmies, Susan Ashby, Charles Ashford, J. W. Ashley-Koch, Allison Ashtari, Manzar Ashton, David Aston, Christopher Atchinson, Kevin P. Ator, Nancy Attarbaschi, Trawat Attner, Michelle Atz, Mary E. Augustyns, Ilse Awad, A. G. Axelson, David Baare, William Bachtell, Ryan K. Badawy, A.A-B. Bahr, Ben Bahr, Ben A. Bailer, Ursula F. Bain, Earle Baker, David Baker, Glen Baker, Ross A. Baker, Sherryl Bakshi, Vaishali Baldessarini, Ross J. Baler, Ruben Ballinger, Dennis Banerji, MaryAnn Bannai, Makoto Bannet, Yair Barbano, PaoloEmilio Barch, Deanna Barefoot, John Barker, Eric L. Barnett, Alan S. Barot, Sabiha Barr, Christina S. 109, 113, 135 Barranco, Eva Page 192 125 100, Barres, Ben Barrett, Andrew C. Barrett, James E. Barrett, Sean P. Barrett, Thomas B. Barros, Tanya Barry, Audrey Bartko, John Barzman, Drew H. Baskys, Andrius Baucum, Anthony J. Bauer, Jochen Bauer, Michael Bauer, Theresa Baumann, Michael H. Baxter, Lewis R. Bayazitov, Ildar T. Bazinet, Richard P. Bear, Mark Beard, Laura Bearden, Carrie Beasley, Jr., Charles M. Becker, Carl Becker, Jill Becker, Kevin G. Beebe, Katherine L. Beesdo, Katja Begleiter, H. Beguin, Cecile Belfer, Inna Belknap, John K. Bell, Richard L. Beltaifa, Senda Belzung, Catherine Bendle, Scott Bendor, Jacob T. Benedetti, Francesco Beneyto, Monica Benkelfat, Chawki 116 Bentin, Shlomo Berga, Sarah L. Bergeron, Richard Berghorst, Lisa Berghorst, Lisa H. 90 148 89 133, 146 151 100 150 90 148 145 153 145 109 101 117 119 91 106 77 108 116, 118 95 101 122 100, 152 92 64 95 80 103 114 94 143 117 139 133, 146 91 137 114 92, 95, 99 192 65 91 146 113 149 120 106 100 94 153 107 98 95 151 97 143 153 154 73 144 140 95, 126 138 43 155 106 95 134 97 125 134 135 101 90 152 134 76 101 95, 113, 102 138 95 142 117 Author Index 11/17/05 7:49 AM Bergman, Jack Berman, Karen Berman, Karen F. Berman, Robert M. Berman, Steven M. Berney, Alexandre Bernotas, Ron Berns, Gregory S. Berrettini, Wade Bertisch, Hilary C. Berton, Olivier Bescholt, Anita J. Best, Susan E. Betensky, Julia Bethea, Cynthia L. Beyer, Chad Beyers, Karen Bhaskar, Kolachana S. Bhattacharjee, Abesh Bi, Wenzhu Bidesi, Anup Bidwell, L. Cinnamon Biederer, Thomas Biederman, Joe Biederman, Joseph Biemans, Barbara Bierut, L. Bikker, Angela Bilder, Robert Bilder, Robert M. Binder, Elisabeth B. Binesh, N. Birell, Claire Birkett, Melissa A. Birmaher, Boris Bissette, Garth Bizot, Jean-Charles Bjork, James Blackburn, Thomas P. Blair, James Blakely, Randy Blakely, Randy D. Blanchard, John Blanco, Carlos Blasey, Christine Page 193 92, 126 68 152 96 95, 138 95 109 138 124 103 115 123 91 151 106 148 108 116 139 139 142 102 65 122 118 100 134 145 107, 124 106, 151 92 94 109 142 117, 125 89 121 136 96, 144 99 78 115 103 123 106 Blasi, Giuseppe Blazer, Dan G. Blazer, Daniel Blendy, Julie A. Blier, Pierre Bloch, Michael H. Block, Thaddeus Blumberg, Hilary Bohning, Daryl Boone, Ericka Borba, Christina P. Borckardt, Jeffrey J. Borowsky, Beth Bose, Anjana Bosetti, Francesca Bossie, Cyndi Bossie, Cynthia A. Bottiglieri, Teodoro Bouvier, Michel Bowden, Charles Bowie, Christopher R. Bowlby, Mark Bowman, L. Boyce-Rustay, Janel M. Boyle, Maureen Bradley, Brendan P. Brady, Linda Braff, David 102 Braff, David L. Braff, DL Brambilla, Paolo Branch, Craig Branch, Sarah Branchek, Theresa Branchek, Theresa A. Branchey, Marc Brann, Jessica H. Brannan, Stephen Braun, Miriam Breeder, Christopher Breeze, Janis L. Breier, Alan Breier, Michelle Brennan, Julie 193 116, 138 89 123 123 95, 96 155 106 56 131 120 127 106 101 94 153 104, 105 98, 101 101 33 122 105 109 131 93 104 96 39 49, 101, 105, 129 102 140 103 103 70 96, 144 92 98 143 98 143 118 40, 103 149 148 Author Index 11/17/05 7:49 AM Brennan-Krohn, Thea Brennum, L. Brent, David Brent, David A. Bresnahan, Michaeline Briggs, Hedieh Britton, Jennifer C. Brodsky, Beth S. Brodsky, Marc D. Brody, Arthur L. Brotman, Melissa A. Brown, Alan S. Brown, E. Sherwood Brown, Eileen Brown, Gregory G. Brown, Hendricks Brown, John Brown, Justin Brown, Lawrence S. Brown, Morton B. Brown, Walter Brown, Kyle Brumbach, Barbara H. Brummett, Beverly Brunelle, Caroline Brunet, Alain Brutsche, Nancy Bryan, Holly S. Bucholz, K. Buchsbaum, Monte Buchsbaum, Monte S. Buchwald, Dedra Buckholtz, Joshua Buckholtz, Joshua W. 152 Bueller, Joshua Buga, Adriana Buitelaar, Jan Bukstein, Oscar G. Bulik, Cynthia M. Bullich, S. Bunney, William Bunney, William E. Bunt, Gregory Buonanno, Andres Page 194 119 150 49, 117 125 101 106 137 125 92 143 96 101 144 99 117 145 120 98 92 146 107 103 99 133, 146 113 96 146 126 134 140 138 143 102, 140 116, 141, Burdick, Katherine E. Burk, Gary M. Burmeister, Margit 145 Burns, Donald Burroughs, Eliza Bustillo, Juan R. Butler, Pamela Butler, Pamela D. Butterfield, Marian I. Butters, Meryl A. Buxbaum, Joseph D. Buydens, Laure Byerley, Bill Bymaster, Frank Bystritsky, Alexander Cabrera, David M. Cadenhead, Kristin Cadenhead, KS Cagliero, Enrico Caine, S. B. Caine, Simon B. Calabrese, Joseph Calabrese, Joseph R. Caldirola, Patrizia Caleo, Sue Calkins, ME Calkins, Monica E. Callaghan, John T. Callicott, Joseph Callicott, Joseph H. 116, 127, 138, 141, 152 Callicott, Joseph S. Campbell, Bryan J. Canive, Jose M. Cannon, Dara M. Canuso, Carla M. Cao, Jianjing Caparelli, Elisabeth C. Capece, Julie A. Capuron, Lucile Carballo, Juan J. Carlezon, William Carlezon, William A. 136 138 149 48 140 107 141 76 145 134 82 194 102, 132 105 96, 119, 39 95 102 75 102 89 124 23, 132 92 124 98 96 154 101, 102 102 127, 152 91 92 122, 144 146 70 104 102 147 98 140 90, 102, 141 142 130 96 98, 124 134 111 108 109, 138 135 97 97, 124, Author Index 11/17/05 7:49 AM Carlson, Gabrielle Carlson, Janice Carlson, Paul Carlson, Robert Carlson, Susan E. Caron, Judy Caron, Marc Carpenter, David Carpenter, Linda Carpenter, Linda L. Carpenter, William Carroll, F. I. Carson, Richard E. Carson, William Cartagena, Preston Carter, Cameron Carvalho, John P. Cassano, Hope L. Castellanos, F. Xavier Caster, Joseph M. Castillo, Desiree Castro, Mariana Pereira Catafau, Ana Cato, Margaret A. Cavazzoni, Patrizia A. Caviness, Verne S. Cecil, Kim Cecil, Kim M. Cepeda, Carlos Ceryak, Dave Cha, Joo H. Chang, Kiki Chang, Lin Chang-Gyu Hahn Chaplin, William Chappell, Amy S. Chappell, Phillip B. Charney, Dennis Charney, Dennis S. Chau, David T. Chen, Bin Chen, Gang Chen, Guang Chen, Heidi Chen, Jin-Chung Page 195 122 151 146 91 122 97 41, 60 140 145 114 40 112 136, 139 130 145 45 114 102 117 112 152 105 141 117 95 118 117 126 108 38 134 56, 97 138 82 114, 115 107 106 74 125, 146 111 109 120, 141 97 144 51 Chen, Jingshan Chen, Qiang Chen, Robert Chen, Scott A. Chen, Stanford Chen, Ying Chen, Yue Chen, Yuejin Chen, J. Chengappa, K.N. Roy Childs, Emma Chin, Ronald B. Cho, William Choi, Sang-Ho Chong, Rachel Choudary, Prabha V. Chourbaji, Sabine Chowdari, Kodavali V. Christensen, Jon Chua, Hannah F. Chue, Pierre Chui, Helena Church, Timothy S. Ciccone, Patrick E. Clark, Janet Clasen, Liv Clauw, Daniel Claycomb, Robert Clinton, Sarah Coccaro, Emil F. 137 Cody, Heather Cohan, Jeannette Cohen, Bruce M. Cohen, Caroline Cohen, Jonathan Cohen, Miriam Cohen, Ronald A. Colantuoni, Carlo Cole, Derek Collins, Daphne Comer, Sandra D. Comery, Thomas A. Compton, Wilson M. Confer, Andrea L. 195 41, 116 116, 152 103 92 151 105 102 108 151 143 93 150 103 153 146 145 120 147 139 118 150 89 121 123 97 105, 115 46 108 97 108, 117, 116 117 97, 124 121 52 100 136 155 109 155 112 90 92 138 Author Index 11/17/05 7:49 AM Conley, Rachel Conley, Robert 154 Conley, Robert R. Connor, Kathryn M. Constable, R. T. Conti, Alana C. C. Conti, Lisa Conway, Kevin P. Cook, Edwin H. Cook, Glen A. Cooper, Thomas Cooper, Thomas B. Cooperberg, Mark D. Copeland, Paul M. Coplan, Jeremy Coplan, Jeremy D. Corcoran, Cheryl Corfas, Gabriel Correia, Stephen Correll, Christoph U. Corrigan, Brian Corrigan, Mark Corripio, I. Cortese, Bernadette M. Corya, Sara Coryell, Bill Costa, Erminio Coste, Sarah Cotton, Aronica Cottone, Lisa A. Covell, Julie Covington, Herbert E. Cox, David R. Coyle, Joseph Craig, Douglas A. Craiglow, Britt Crandall, David 143, 152 Creson, Thomas Crissman, Alicia M. Croft, Rodney J. Crosson, Bruce A. Crow, Scott J. Cruz, Rick Page 196 97 98, 103, Cryan, John F. Csernansky, John Cubells, Joseph Cubells, Joseph F. Cubero, Pedro Cui, Lihong Cummings, Jeffrey Cunningham, Kathryn A. Cunningham, Miles Cunningham, Miles G. Cutler, David Czachowski, Cristine Czeisler, Charles A. D’Souza, Deepak Daniel, David G. Danus, M. Darwin, C. Das, Saumitra Daskalakis, Zafiris J. Davenport, Nicholas Davidson, Jonathan Davidson, Jonathan R. Davidson, Michael Davis, John Davis, Kenneth Davis, Kenneth L. 140 Davis, Michael Davis, Nicole Y. Daws, Lynette Daws, Lynette C. De Kloet, Carien De Leon, Mony J. De Wit, Harriet Deadwyler, Samuel Dean, Michael Deas, Deborah DeBattista, Charles Deckert, Juergen Deckert, Jurgen Decobert, Michel Deep-Soboslay, Amy Degenhardt, Elisabeth DeKosky, Steven T. 139 128 97 104 123 64 92 134 107 129, 139 135 146 127 126 114, 137 128, 130 63 119 132 106 97 141 123 151 124 105 142 137 111 120 124 103 132 96, 144 155 130, 131, 97 125 138 117 107 107 196 54 72 31 92 100 123, 124 91 111 25 97 86 92 109 77 100 141 94 90, 138 103 152 97 123 101 100 89 23, 132, 84 109 93 107 145 44, 90 93, 134 91 29 93 106 98 93 121 102 99 124, 138, Author Index 11/17/05 7:49 AM Delahanty, Ryan J. DelBello, Melissa DelBello, Melissa P. 117, 126, 144 DeLisi, Lynn E. DeLory, Michael Demitrashvili, Marina Dence, Carmen S. Denslow, Stewart Derby, Eric DeRosse, Pamela Detke, Michael J. Deutch, Ariel DeVane, Lindsay Devous, Michael D. Di Martino, Adriana Diamond, Pamela Dick, D. Dickstein, Daniel P. Dieterich, Megan E. Diksic, Mirko DiNieri, Jennifer A. Dittman, Ralf Diwadkar, Vaibhav A. Dobie, DJ Dobie, Dorcas J. Dobkin, Roseanne D. Docherty, John Dombrowski, Philip Dominguez, Juan M. Domino, Edward Domschke, Katharina E. Donalds, Rachael Donati, Robert Donovan, Jennifer Dorsa, Daniel Dossenbach, Martin Dougherty, Donald M. Douglas, Louisa Drabant, Emily M. Dreher, Jean-Claude Dremencov, Eliyahu Drevets, Wayne C. 120, 123, 125, 138 Driesen, Naomi R. Page 197 115 56, 122 94, 103, DSouza, Deborah N. 95, 107 Du, Jing 69, 98 Dube, S. 131 Dubocovich, M. L. 154 Dubocovich, Margarita 76 Dugan, Laura 34 Dulawa, Stephanie C. 98 Dumalska, Iryna 153 Duman, Ronald S. 153 Dunlap, Steven 117 Dunlop, John 126, 148 Dunn, Laura B. 106 Dunner, David 99 Dunner, David L. 98 Durkin, Margaret 96 Duytschaever, Hilde 100 Dwivedi, Yogesh 98, 125, 154 Dworakowski, Diana 117 Dwork, Andrew 126 Eastvold, Angela 102 Eckelman, William C. 139 Edenberg, H. 134 Edwards, Robert H. 154 Eerdekens, Els 130 Eerdekens, Marielle 127, 130 Egan, M. 151 Egan, Michael 152 Egan, Michael F. 90, 102, 116, 138, 141, 149, 150, 152 Ehlers, Cindy L. 93, 136 Ehrlichmen, Richard S. 149 Eichenbaum, Howard 59 Eidelberg, David 90 Eiduson, Samuel 96 Eisen, Seth A. 142 Ekholm, Jenny 129 Ekholm, Jenny M. 132 El Mansari, Mostafa 96 Elliott, Mark 147 Ellis, Jamey 132 Ellis, Steven P. 125 Elman, Igor 117 Eltayb, Amani 150 Emanuel, Ezekiel 40 103 92 138 138 131 100 102 98, 107 67, 97 103, 131 91 117 152 134 117 118 95, 116 97 122, 151 117, 128 102 147 98 104 155 98 51 98 97 98 103 43 126 106 100 116 152 96 96, 118, 104 197 Author Index 11/17/05 7:49 AM Engel, Sharon Engelhart, Luella Engelien, Almut Enoch, Mary-Anne Entsuah, Richard Epperly, Garretson D. Epping, Eric Ereshefsky, Larry Erickson, Kristine 118 Eriksson, Bo Ernst, Monique Ervin, John Escamilla, Michael A. Esposito, Giuseppe Esposito, Michael Esser, Steve K. Essock, Susan Estrada, Jose Evans, Alan Evans, Christopher Evans, Karleyton Evans, Ken Evans, Simon J. Evans, Suzette M. Evins, A. Eden Ewing, Sarah B. Fabian, Sara Faccidomo, Sara P. Faison, Warachal E. Fang, Liwei Farabaugh, Amy H. Farber, Robert Farde, Lars Faries, Douglas Faustman, William O. Fava, Maurizio 120, 126 Feder, Adriana Feifel, David Feldman, Ruth Feldon, Joram Feltenstein, Matthew W. Ferguson, James M. Fernandes, Prabhavathi Page 198 97 107 98 136 99 154 116 152 26, 115, Ferrarelli, Fabio Ferris, Steven Findling, Robert Findling, Robert L. Finger, Elizabeth Fink-Jensen, Anders Fisch, Hans-Ulrich Fischer, Andre Fischer, Grace Fischman, Alan J. Fish, Colin Fisher, Alan C. Fissell, Kate Fitterling, Heidi Fitzgerald, Daniel A. 137 Fitzgerald, Kate D. Flagel, Shelly B. Fleck, David E. Fleckenstein, Annette Flick, Rosemarie B. Flor, Herta Flores, Osvaldo Floresco, Stan B. Floyd, Bloom E. Foltin, Richard W. 112 Ford, Judith Ford, Judith M. Ford, Lisa Foroud, T. Fountain, Sarah I. France, Adrian K. France, Charles P. Francesconi, Anna Francon, Dominique Frank, Ellen Frank, Guido F. Frank, Guido K. Frank, L. Frank, Richard Frankle, Gordon W. Frankle, WG Frazer, Alan Frazier, Jean A. 104 142 89 105 139 126 132 55 105 105, 115 85 118 99 145 93 93, 120 112 153 94 89 153 93 106 39 100, 103 104 93, 97, 99, 137 104 140 35 94, 135 99 104 198 132 90 122 109, 146 99 92 143 154 123 134 39 108 141 137 108, 117, 118 93 99 107 97 120 97 94, 126 90 93, 111, 27 104 127, 130 134 103 93 93, 112 50 121 79 116 118 131 39 129 118 107 118, 151 Author Index 11/17/05 7:49 AM Frederick, Blaise Frederick, Blaise D. Fredrickson, Barbara L. Free, R. B. Freed, William J. Freedman, Robert Freeman, Marlene P. Freudenreich, Oliver Friberg, Lars Frick, Caroline Friedman, Joseph I. Frol, Alan B. Fromm, Stephem Frye, Mark A. Fu, Dong-Jing Fuchs, Rita A. Funke, Birgit Furey, Maura L. Furman, Daniella Fusco, Maureen Fyall, Amber Gable, Karissa L. Gabrieli, John Gadde, Kishore Gagne, Gerard G. Galaburda, Albert Galit, Yovel Gallagher, Paul Gallelli, Kim Galli, Aurelio Gallitano-Mendel, Amelia Galloway, Matthew Galloway, Matthew P. Galper, Daniel I. Gandhi, Shilpa K. Gao, Sujuan Garlow, S. Garlow, Steven J. Gass, Peter Gassmann-Mayer, C. Gatley, Samuel Gaylo, Paul Gelenberg, Alan Gelenberg, Alan J. Gelernter, Joel Page 199 117 134 140 154 155 132 99 105 119 143 89, 140 144 96 99 103 94 102 118, 120 152 89 111 115 59 109 114 37 102 100 97 93 104 102 118, 138 121 96 116 122 120 120 127 77 39 107 99, 122 140 Gemelli, Terry Genius, Just George, Mark S. 131 George, Tony P. Georgieva, Lyudmila Gerald, Christophe P. Gerety, Lyle P. Gerhardt, Greg A. Gerig, Guido Gerlach, Lauren Gershon, Elliot Geuze, Elbert Geyer, Christopher Geyer, Mark 142 Geyer, Mark A. Gharabawai, Georges Gharabawi, Georges 105, 107, 155 Gharabawi, Georges M. Ghosh, Debashis Ghuman, Harinder S. Ghuman, Jaswinder K. Giardino, Odessa Gibbons, Robert D. Gibbs, E. M. Gibert, Stephen Gibson, Brian Giedd, Jay 105 Giedd, Jay N. Giegling, Ina Gil, Lucas Gil, Mario Gil, Roberto Gilliam, T. C. Gilmore, John 114 Gilmore, John H. Gingrich, Jay A. Ginter, P. Giuffrida, Andrea Glahn, David C. Glaser, Paul E. 199 115 109 104, 106, 105 132 96, 144 124 154 114, 119 112 86, 124 119 136 36, 64, 72, 116 106 95, 104, 101, 124 96 107 107 101 145 148 106 103 37, 81, 115 109 122 98 129 134 26, 36, 115, 119 98 154 107 105 154 Author Index 11/17/05 7:49 AM Page 200 Glass, Richard 38 Glass, Steven J. 107 Glassman, Alexander 38 Glenthoj, Birte 27 Glenthoj, Birte Y. 119 Glick, Ira 79 Glimcher, Paul 52 Glitz, Debra A. 123 Glover, Gary 104 Goate, A. 134 Godbout, Roger 147 Goeders, Nicholas E. 111 Goetz, Raymond 128 Goetz, Raymond R. 128 Goff, Donald C. 105, 127, 152 Gogtay, Nitin 27, 105 Gold, James M. 131 Gold, Philip 115 Goldberg, Jack 143 Goldberg, Steven 80 Goldberg, Steven R. 113 Goldberg, Terry 59, 90 Goldberg, Terry E. 116, 120, 150 Goldman, Aaron L. 120, 127, 141 Goldman, David 29, 58, 95, 109, 113, 116, 125, 129, 136, 137 Goldman, James E. 23 Goldman-Rakic, P. S. 104 Goldstein, David J. 107 Goldstein, Rita Z. 111 Golembo, Nicole 100 Goletiani, Nathalie V. 111, 114 Goltser-Dubner, Tanya 149 Golzer, Tanya 125 Gonsai, Kishor 112 Gonzalez, Gerardo 112 Goodman, M. 118 Goodman, Mark M. 112 Goodman, Wayne K. 120 Goodwin, Guy 48 Gordon, Joshua 25 Gordon, Joshua A. 120 200 Gorman, Jack 140 Gould, Georgianna G. Gould, Todd Gould, Todd D. Grace, Anthony Granholm, Eric L. Grannemann, Bruce D. Grant, Jon Grant, Kathleen A. Grant, Merida M. Grant, Richard W. Grant, Steven Grauer, Steve Gravel, Paul Gray, May Grayson, Dennis R. Green, Alan I. Green, Michael F. Greenhill, Laurence Greenspan, Andrew Greenstein, Deanna Greenstein, Dede Greenwood, Tiffany A. Greer, Tracy L. Greisenegger, Erika Greist, JH Griebel, Guy Griffith, Gayle Grigoriadis, Dimitri E. 142 Grimm, Jeffrey W. Grossman, Hillel Gruber, Staci A. Grunder, Gerhard Grundt, Peter Grunze, Heinz Gu, Hongbin Guidotti, Alessandro Guilfoyle, David G. Guimaraes, Angela Gunderson, Erik Gunduz-Bruce, H. 151 Gur, Eitan 40, 47, 107 60 121 42, 66 117 121, 145 119 113 119 152 52 126 95, 116 104 105 111 105 125 101 105 115 105 121 140 110 121 102 106, 121, 111 89 132, 137 119 91 48, 109 127 105 132 152 112 129, 148, 125 Author Index 11/17/05 7:49 AM Page 201 Gur, Raquel 105 Gur, Raquel E. 147 Gur, Ruben 75 Gur, Ruben C. 128, Gutierrez-Esteinou, R. 131, Gwaltney, Chad 114 Gyulai, Laszlo 122 Hahn, Chang-Gyu 82 Hahn, Maureen 78 Haile, Colin N. 108 Hajianpour, Arash 140 Hall, Jerry A. 107 Hamer, Robert 127 Hamer, Robert M. 130 Hammer, Ronald 64 Hammer, Ronald P. 100 Hammonds, Michael 144 Han, Qiao 115 Handa, Robert J. 89 Haney, Margaret 111, Hannigan, John H. 118 Hanson, Glen R. 107 Hao, YanLei 97 Harding, Richard 124 Hariri, Ahmad R. 138 Haroon, E 94 Haroutunian, Vahram 101, 132, 147 Harral, Erin 139 Harris, James 49 Harris, Thomas S. 91 Harrison, Boyd 126, Harrison, P. J. 151 Hart, Carl 111 Hart, Carl L. 112 Hartmann, Annette 109 Harvey, John A. 109 Harvey, Phil 140 Harvey, Philip D. 105, 124 Haschke, Eric 101 Hasdemir, Mustafa 143 Hashemzadeh, Mehrtash 148 Hassan, Khader M. 111 Hassel, Stefanie 141 Hassman, Howard A. Hastings, Ramin S. Haubenreich, Kristen M. Hawk, Josh Hayashi, Kiralee M. Hazelwood, Lisa A. Hazlett, Erin A. Heaton, Robert Heberlein, Ulrike Hebert, Chantal Heckers, Stephan Heerey, Erin A. Hegerl, Ulrich Heijnen, Cobi J. Heilig, Markus Heim, Christine Heindel, Walter Heinz, Andreas Heitzeg, Mary Helboe, L. Hellweg, Rainer Helmstetter, Fred Hemmingsen, Ralf Hen, Rene 120 Henck, Judith W. Henderson, David C. Henke, Bettina Henn, Fritz A. Henry, Brian Henry, Shannan E. Hensler, Julie G. Herbener, Ellen Herbert, Martha R. Heresco, Uriel Hermann, Carol Hernandez, Olivia Herremans, A. H. J. Herringa, Ryan J. Herscovitch, Peter 139 Hertel, Peter Hesselbrock, V Hesselink, Mayke 147 152 112 128, 148 106, 201 107 121 118 153 140 154 138 102 103 95 59 131 109 145 61 121, 153 98 136 119 150 120 84 119 90, 98, 98 127, 152 124 120 151 116 121 139 118 102 90 139 150 142 125, 136, 130, 150 134 150 Author Index 11/17/05 7:49 AM Higley, J. D. 109, 113, 115 Higley, James Higley, James D. Hill, Rebecca Hiranita, Takato Ho, Beng-Choon Ho, Shao-Hsuan Hobbs, Katherine Hockett, Richard D. Hodge, Steven M. Hodgkinson, Colin A. Hoebel, Bartley Hof, Patrick Hoffmann, Robert Hogarty, Gerald E. Hoge, Jessica A. Hohoff, Christa Hokfelt, Tomas Holcomb, Henry H. Holick, Kerri A. Holik, Alexander Holland, Christine Holland, Scott K. Hollander, Eric 115 Hollon, Steven D. Holmes, Andrew Holston, Rachel E. Holt, Richard Holzman, Philip Hommer, Daniel Honea, Robyn Honea, Robyn A. Hooper-Wood, Christa Hoptman, Matthew Hoptman, Matthew J. Horan, William Horgan, Jennifer Horner, Michael Hortnagl, Heide Houseknecht, K. L. Houston, John Howe, Meghan Howell, Leonard L. Page 202 92, 95, Hrabe, Jan Huang, Hsien-Sung Huang, Xiaohong Huang, Y. Huang, Ying Huang, Yiyun Huang, Yung-yu Huang, Z. Josh Huber, Reto Hudson, James I. Hudson, R. L. Huffaker, Stephen J. Huganir, Richard Hulette, Christine Hulihan, Joseph F. Hull, Elaine M. Hunt, Rachel A. Hustig, Harry Hutson, Peter H. Hwang, D-R Hwang, Dah-Ren Hyde, Christopher Hyde, Thomas M. 155 Ice, Kathleen Ichise, Masahiro Indersmitten, Tim Ingham, Mike Innis, Robert Insanally, Michele Iskander, L. Iudicello, Jennifer Ivleva, Elena Iyengar, Malini Iyengar, Smriti Jack, Blaine Jacob, Suma Jacobi, Frank Jacobs, An Jacobsen, J. S. Jacobson, Ira M. Jaenisch, Rudolf Jaffe, Craig Jagar, A.A. Jagust, William 58 135 99 137 127 137 127, 141 103 118 137 53 140 94 128 124, 139 93, 98 144 129 98 145 152 94 26, 114, 119 93 109 131 102 92, 136 141 127, 141 123 103 132, 134 75 89 131 120 148 99 97 112 202 134 99 122 118 146 129 121 32 132 107, 108 154 127 73 89 143 98 100 104 97 118 129 117 102, 127, 103 96 128 104 39, 68 126 118 116 150 144 98, 107 137 115 95 104 90 109 115 112 106 89 Author Index 11/17/05 7:49 AM Jalbrzikowski, Maria Jamal, Mazan Jardemark, Kent E. Jarskog, L. F. Jarvis, Kelly Javitch, Jonathan Javitt, Daniel Javitt, Daniel C. Jayathilake, Karu Jennifer, Wilkerson Jentsch, J. David Jentsch, J. D. Jeste, Dilip Jeste, Dilip V. Jiang, Lan Jiang, Qin Jina, Anil S. Jochims, Anja Johanson, Chris-Ellyn Johnson, Brandy Johnson, D. E. Johnson, Kevin Johnson, Sandra Johnson, Steven Johnson-Davis, K. L. Johnston, Daniel Jokinen, Jussi Jomier, Matthieu Jones, Doug Jones, Douglas W. Jones, Edward G. Jones, Kenneth A. Joshi, Sarang Joyce, B. M. Jurata, Jurata W. Kadiyala, Sridhar Kail, Melanie Kalali, Amir H. Kalin, Ned H. Kalivas, Peter Kalivas, Peter W. Kamanna, Vaijinath Kamel, Niveen Kamens, Helen M. Page 203 102 148 130 115 94 33 75 102, 132 108, 131 115 103 113 34, 62 106 115 123, 145 100, 152 119 136 144 148 131 38 105 107 148 125 119 140 137 145 96 119 154 100 90 133, 146 101 121, 142 57, 80 151 153 99 134 Kane, John 151, 154 Kane, John M. 127, 129, 132 Kanes, Stephen J. Kanes, Steve Kanwisher, Nancy Kapur, Shitij Karagille, Ayse T. Karanian, David A. Karatekin, Canan Karson, Craig Kashyap, Moti L. Kasper, Siegfried Katz, Jonathan L. Kauer, Julie Kaufman, Daniel Kaufman, Marc J. Kavalali, Ege Kavelaars, Annemieke Kaye, Walter H. Ke, Yong Keck, Martin Keefe, Richard Keenan, Kate Kegeles, Lawrence S. Kehoe, Priscilla Keirstead, Hans Keitner, G. I. Keller, David Keller, Martin B. Kelley, Ann E. Kelley, Mary E. Kelly, Deanna L. Kelly, Erin Kelly, Michele Kelsey, Douglas K. Kelsoe, John 124 Kelsoe, John R. Kendi, Mustafa Kenna, George A. Kenna, Heather A. Kennedy, David N. Kennedy, James 203 130, 148, 100, 102, 151 126 102 41 152 108 152 121 153 145 134 73 114 120, 134 115 145 116, 118 132 109 127 115 128, 129 108 23 122 103 122 135 147 128 149 126 108 86, 116, 149, 151 152 112 142 118 58 Author Index 11/17/05 7:49 AM Kennedy, James L. Kenny, Paul J. Kent, Justine M. Kentros, Clifford G. Kerr, Natalie Kersting, Anette Kerwin, Lauren Keshavan, Matcheri Keshavan, Matcheri S. 140, 147 Ketchum, Katherine Ketter, Terence Ketter, Terence A. Khadivi, Ali Khan, Alea Khan, Arif Khan, Samir Khanal, Mandar Kieres, Artur K. Kim, Dong-Wook Kim, Jeansok J. Kim, Kwang-Soo Kimhy, David Kimmel, Heather L. Kingshott, Elesha Kinkead, Becky Kinon, B. Kinon, Bruce Kinon, Bruce J. Kipp, Heidi Kirkwood, Sandra Close Kirov, George Kirshner, Margaret Kleber, Herbert Klein, Daniel N. Klein, Donald Klein, Lauren Klein, Nikolas Klein, Peter Kleinman, Joel E. 155 Kleinman, L. Kletter, Kurt Klock, Allan Page 204 95 112 139 120 141 98 96 147 117, 128, Klunk, William E. 139 Knable, Michael Knadler, Mary Pat Knoll, Allison T. Koch, Paul Kocsis, James H. Koe, B. K. Koek, Wouter Kohler, Christian G. Kohn, Philip Kolachana, B. S. 141, 149, 150, 151 Kolb, Hartmuth Kolko, David Kolts, Russell Konkel, Michael J. Konradsson, Asa Koob, George Koob, George F. Koola, Jejo Kopajtic, Theresa Korotzer, Andrew Kosel, Markus Kosik-Gonzalez, Colette Kosten, Therese A. Kosten, Thomas Kosten, Thomas R. Kostic, Dusan Kowatch, Robert 144 Kowatch, Robert A. Kozel, F. A. Kozel, Frank A. Kraemer, Helena C. Kral, John G. Kramer, Elisse Kramer, J. Kramer, Joel Kramer, Larry Kramer, Michelle Krefetz, David G. Kreilgard, M. Krishen, Alok Kristiansen, Lars V. 89 79 122 148 149 107 106 112 124 97 108 78, 97 128, 130 112 90 67 131 103, 128 100 140 103 132 90 130 122 38 136 145 60 102, 127, 131 145 108 204 124, 138, 104 98 124 152 122 148 112 128 152 90, 138, 39 125 107 96, 144 130 53, 61 134 131 134 94 143 101, 104 108 31 108, 112 130, 143 103, 122, 94, 99 104, 106 131 89 114 90 134 89 111 127, 130 107 150 126 128, 147 Author Index 11/17/05 7:49 AM Kritz, Steven Krupitsky, Evgeny M. Krystal, John Krystal, John H. Kryzhanovskaya, Ludmila Kucherlapati, Raju Kuczenski, Ronald Kuczora, Meaghan Kugel, Harald Kuhn, Cynthia Kuhn, Cynthia M. Kumar, A. Kumaran, S. Kumra, Sanjiv Kuperman, S. Kupfer, David J. Kussmaul, Lucinda Kyle, Kampman Lacefield, Clay O. Ladouceur, Cecile D. Laeng, Pascal Lahti, Adrienne Lahti, Adrienne C. Lai, Cary Laird, Nan M. Lal, Harbans Lalonde, Justine K. Lam, Francis LaMantia, A. S. Lambe, Evelyn K. Lamberti, J. S. Landinez, Johanna Landry, Charles F. Lanfranco, Marie F. Langefeld, Carl Lanius, Ruth Lanzenberger, Rupert Lara, Nathalie LaRossa, Gina N. Laruelle, M. Laruelle, Marc 129 Lattal, K. Matthew Lavin, Antonieta Lavretsky, Helen Page 205 92 112 32 104 122, 151 102 149 149 98 146 109, 112 94 94 151 134 141 91 136 120 141 100 100 129 82 107 107 107 152 115 129 105 144 135 111 124 74 145 122 138 118 26, 128, Law, Amanda Lawson, David H. Le Foll, Bernard Le Guisquet, A.M. Le Melledo, Jean-Michel Leckman, James Leckman, James F. Lee, Buyean Lee, David Y. Lee, Ho-Joo Lee, Royce Lee, Sang Y. Lee, Soon Y. Leherecy, Stephane Lehrmann, Elin Leibenluft, Ellen 117, 142 Leibowitz, Sarah Leman, Samuel Lemire, Andrew Lemmon, Vance Lenane, Marge Lenartz, Doris Lencz, Todd 151 Lenox, Robert Lenroot, Rhoshel Leon, Andrew Leow, Alex D. Lerch, Jason Lerer, Bernard Lesage, Anne Lesser, Martin Leung, Hoi-Chung Levant, Beth Lever, John R. Levin, Edward D. Levine, Ari Levine, Louise Levine, Michael S. Levitt, Pat Levy, Mya E. Lewis, David Lewis, David A. Lewis, Lydia 153 108 89 205 63 138 113 90 122 155 140 113 97 154 108, 137 138 134 152 155 45, 96, 53 90 100 50 105 143 102, 129, 101 115 105 140 105 125, 149 54 148 104 122, 135 134 129 94 108 108 83 151 32 147 49 Author Index 11/17/05 7:49 AM Lewis, Michael Lewis, Shon Lewis, Stephen F. Lewy, Alfred Leyton, Marco 116 Li, Jun Li, Ting-Kai Li, Wei Li, Xin-Min Li, Yu Li, Z. Li, Zhen Li, Zhu Liang, Shi Libby, Anne M. Liberzon, Israel Lieberman, Jeffery A. Lieberman, Jeffrey 129 Lieberman, Jeffrey A. Lieberman, Joseph A. Liebowitz, Michael Lifschytz, Tsuri Light, Gregory Light, Gregory A. Lim, Kelvin O. 152 Lim, Pilar Lin, Daniel Lin, Ping Lin, Qian Lin, Weili Lindell, Stephen Lindell, Stephen G. Lindenmayer, J-P Linnoila, Markku Lipschitz, Alan Lipska, Barbara Lipska, Barbara K. Lipsky, Robert Lisanby, Sarah H. Litten, Raye Littleton, John Liu, Amy Page 206 53 55 130 76 95, 113, Liu, Danni Liu, Liyan Liu, Yijun Livni, Eli Locklear, Julie Loebel, Antony 131, 144, 148, 154 Lombardo, Illise Lominac, Kevin D. London, Edythe London, Edythe D. Looney, Christopher Lopresti, Brian J. Lorell, Beth Loughead, James Louie, Pearl M. Louis, Caroline Love, Raymond C. Low, Nancy C. Lowe, Mark J. Lu, Bai Lu, Brett Y. Lu, Xueling Luber, Bruce Luckenbaugh, David Lucki, Irwin Lukas, Scott Lukas, Scott E. Lund, Trent D. Lyons, David Ma, Yilong Ma, Zhongze Maas, Luis C. Macciardi, Fabio MacDonald, Jessica Mack, David Mack, Wendy J. Mackeprang, Torben MacKillop, James Madayag, Aric Madras, Bertha K. Maggin, Jeremy Magistretti, Pierre J. Magolda, Ron Mah, Linda 145 135 120 129 116 151 149 108 109 145 106 114 55, 127, 89, 115 130 123 125 101 129, 149 113, 134, 127 122 146 148 114 115 92, 113 149 92 144 41, 81 127 95 123 61 61 135 206 109 101 120 134 95 105, 129, 144 151 51, 138 95, 113 114 124, 139 148 128 127 121 128 123, 124 116 98 130 139 123 125, 146 123 117 134 89 74 90 97 134 149 130 103 89 119 114 101 134 94 23 148 118 Author Index 11/17/05 7:49 AM Maharajh, Keeran Maidment, Karron M. Maier, Steven Mailman, Richard Mailo, Kevin Majcher, Magda Majumdar, Sonalee Makris, Nikos Makriyannis, Alexandros Malaspina, Dolores Malberg, Jessica Malberg, Jessica E. Malenka, Robert Malhotra, Anil Malhotra, Anil K. 132, 151 Malison, Robert Mallinckrodt, CH Mallinger, Alan G. Maloney, Thomas Manaois, Meghan Mandel, Francine Mandelkern, Mark A. Maness, Patricia F. Mani, Shaila Manji, Husseini 123 Manji, Husseini K. 121, 146 Mann, J. J. Mann, J. John Mannaert, Erik Mansbach, Hank Manschreck, Theo Mao, Lian Mao, Xiangling Mao, Xiangling S. Marangell, Lauren Marchuk, Douglas A. Marcovina, Santica M. Marcus, Monica M. Marcus, Ronald Marder, Stephen Marder, Stephen R. Marenco, Stefano Page 207 148 143 36 104 122 103 149 118 77 128, 130 126 123 73 130 102, 129, 31 110 140 111 111 144 95 115 43 60, 83, 98, 23, 97, 135, 139 121,125 119 91 105 107 128 137 122, 123 109 149 130 131, 152 152 130, 132 137 207 Mark, Black Mark, Slifstein Markou, Athina 112, 135 Markowitz, John Marmar, Charles Marquis, Karen 150 Marquis, Karen L. Marsh, Abigail Marsh, D.M. Marsh, Harold M. Martell, Bridget Martin, Kelsey Martin, Kimberly Martinez, James Martis, Brian Martone, Robert Marx, Christine E. Masand, Prakash S. Masliah, Eliezer Mason, Barbara Massari, Carla Massimini, Marcello Mathalon, Daniel H. Mathew, Sanjay J. Mathew, Shiny V. Mathias, C.W. Mathis, Chester Mathis, Chester A. 138, 139 Mattay, Venkata S. 116, 120, 127, 138, 140, Matute, Melissa Maullin, Nathalie Maxwell, Christina Mayer, Emeran Mayer, Emeran A. Mayes, Linda C. Mayhew, Michael B. Maynard, Melissa Mazandarani, Hossein Mazar, Nina McBride, William J. McCall, W. V. 101 129 35, 54, 103 125 90, 126, 148 99 106 118 112 65 130 123 137 90 89 123 108 61 151 132 104, 130 137 127 106 138 116, 124, 90, 102, 141, 152 149 136 149 46 138 140 150 115 126 117 135 97 Author Index 11/17/05 7:49 AM McCarthy, Timothy McCloskey, Michael S. McClure, Erin B. McCohana, Claire W. McConnell, Susan McCormack, Joanne McDonald, Heather McDougle, Christopher McDougle, C. J. McElroy, Susan McElroy, Susan L. McEvoy, Joseph McEvoy, Joseph P. McFarr, Lynn Marcinko McGlashan, Thomas H. McInnes, Lynne A. McInnis, Melvin McKay, Ronald D.G. McKelvey, George M. McKinstry, Robert McLaughlin, Ryan J. McMahon, Francis McMahon, Robert P. McNamara, Robert K. Meador-Woodruff, J. H. 147 Medori, Rossella Meichle, Sean P. Meigs, James B. Meitinger, Thomas Melendez, Gilia Melhem, Nadine Mello, Andrea F. Mello, Marcelo F. Mello, Nancy K. 113, 114 Meloni, Edward G. Meltzer, Carolyn C. 124, 138, 139 Meltzer, David Meltzer, David O. Meltzer, Herbert Y. Mendelowitz, Alan Mendelson, Jack H. 114 Page 208 39 108, 117 142 116 37 148 99 83 115, 151 108 107 55, 127 130 128 130 131 124 30 118 139 94 124 128 135 101, 128, Meng, Fan 145 Menza, Matthew 98 Merchant, Kalpana 147 Meredith, Charles W. 112 Merikangas, Kathleen R. 123, 124 Merzenich, Michael 152 Meulman, Ellen 145 Meyenberg, Naxhielli 105 Meyer, E. T. 134 Meyer, Jonathan 131 Meyer, Roger 38 Meyer-Gomes, Katrin 129 Meyer-Lindenberg, A. 29, 68, 90, 120, 138, 141 Meyer-Lindenburg, A. 127 Meyers, Adam 128 Mezey, Eva 97 Miceli, Jeffrey 103 Miczek, Klaus A. 94, 124 Mien, Key 145 Mikell, Charles B. 128 Milak, Matthew S. 135 Milbrandt, Jeffrey 104 Milham, Michael 117 Miller, Alexander 105 Miller, Alexander L. 152 Miller, Andrew 153 Miller, Andrew H. 109, 138 Miller, Gregory A. 130 Miller, J. 94 Miller, Rachel 148 Miller, Raymond 106 Miller, Sue 97 Miller, Tandy J. 130 Milligan, Graeme 33 Mintun, Mark 26, 139 Mintun, Mark A. 138 Mintzer, Jacobo 131, 148 Miranda, Robert 114 Mirsky, Allan F. 90 Mitchell, Paul J. 126 Mitkus, Shruti N. 127 Mitterhauser, Markus 145 Mizoguchi, Hiroyuki 90 Mletzko, Tanja 121 119 147 152 109 104 125 114 114 111, 112, 124 116, 118, 38 131 108, 131 148 111, 113, 208 Author Index 11/17/05 7:49 AM Mletzko, Tanya Moberg, Paul J. Moeller, F. Gerard Moeller, Frederick G. Mogg, Karin Mohs, Richard Moinuddin, Asif Moller, Hans-Jurgen Molloy, Fredrick Molnar, Chris Mondal, Amal C. Monk, Christopher S. Monkul, Serap E. Montague, Read Monteggia, Lisa Monteggia, Lisa M. Monti, Peter Montrose, Debra M. Moore, Gregory J. Moore, Shonagh K. O’Leary Moran-Gates, Taylor Morgan, C.J. Morozova, Elena Morrato, Elaine H. Morris, John Morris, John C. Morris, Sarah Morris, Sarah E. Morrison, John H. Morrow, A. Leslie Mosconi, Matthew Moscrip, Tammy D. Moses-Kolko, Eydie L. Mossaheb, Nilufar Mouri, Akihiro Mu, Qiwen Mueller, Bryon A. Muglia, Louis Mukherjee, Jogesh Mukhopadhyay, Nitai D. Mulert, Christoph Mulia, Pierandrea Muller, Walter E. Mungas, Dan Munn, Jaclyn L. Page 209 153 151 111 144 96 128, 131 139 109 149 104, 131 125 96 140 52 91, 115 121 114 117 123 118 151 106 153 145 44 138 112 131 90 113 116 123 138 145 90 104 113 104 155 103 109 109 124 89 93 Murphy, Anne Murphy, James M. Murphy, Kerry L. Murre, Jaap Murrell, Jill Muse, Robert Musgnung, Jeff Musselman, Dominique L. Mutel, Vincent Myers, Richard M. Naber, Dieter Nabeshima, Toshitaka Nader, Karim Nagappan, Guhan Nahas, Ziad Naliboff, Bruce D. Nanda, Steve A. Napierata, Lee Napolitano, Barbara Narasimhan, Meera Narayana, Ponnada A. Narendran, Raj Narvaez, Jenille M. Nash, Laurie Nasrallah, Henry Nasrallah, Henry A. Nathan, Pradeep J. Nayak, Sahana Neale, Ann Neary, Alaina C. Nedza, F. M. Negus, S. S. 113 Nelson, David Nelson, Erika Nemeroff, C. B. Nemeroff, Charles 124, 153 Nemeroff, Charles B. 121, 138 Nettler, Steven Neuhold, Lisa Neumaier, John Neumaier, John F. Neumeister, Alexander 209 85 135 118 59 116 40 145 121 54 145 104, 126 51, 90 96 98 104, 131 138 121 91, 97 148, 151 124 111 129 151 134 131 131 137, 138 100 70 149 148 91, 112, 70 115 122 29, 46, 67, 92, 114, 100 137 70 114 125 Author Index 11/17/05 7:49 AM Neve, Rachael L. New, Antonia S. New, AS Newman, Amy H. Newman, Michael E. Newman, Stephen Newman, Timothy K. Newmark, Randall E. Neylan, Thomas Neylan, Thomas C. Ng, Johnny Nguyen, Chau H. Niaura, Raymond Nichols, Charles Nichols, David Nicoletti, Mark A. Nicolini, Humberto Niebler, Gwendolyn E. Nierenberg, AA Nierenberg, Andrew Nierenberg, Jay Nikulina, Ella M. Nimgaonkar, Vishwajit L. Ninan, P. T. Ninan, Philip T. Nnadi, Charles Noda, Yukihiro Nofzinger, Eric A. Noll, Douglas C. Noonan, Carolyn Nordstrom, Anna-Lena Nordstrom, Peter Nuechterlein, Keith Nugent, Allison C. Nurnberger, John Nurnberger, John I. Nutche, Jeffrey Nutche, Jeffrey J. Nutt, David Nutt, David J. O’Brien, Charles 136 O’Brien, Charles P. O’Connor, Megan M. O’Dell, Laura E. Page 210 91, 136 138 118 91, 134 125 122 95, 109 138 125 147 140 154 71 132 104 140 105 109 110 122 132, 134 124 147 122 122 132 90 147 140 143 125 125 105 96, 118 124 116, 134 147 117, 128 48 126 38, 57, 71, 112 139 134 210 O’Donnell, James M. O’Donnell, Kelley C. O’Donnell, Patricio O’Donovan, Michael O’Hara, Ruth O’Neill, Barry Ogden, R. Todd Ohl, Frauke Ohrmann, Patricia Olfson, Mark Olin, Jason Olincy, A. Olincy, Ann 147 Oliveto, Alison Olsen, C. K. Olson, David P. Olson, Valerie Ongur, Dost Oquendo, Maria A. 135, 139, 145 Oren, Dan Orr, Scott P. Osincup, Dan Oster, Scott M. Oswald, Lynn Otte, Christian Ouellet, Danielle Owen, Michael Owens, Michael J. Owens, W. A. Ozdemir, Vural Pace, Thaddeus Pagnoni, Giuseppe Pai, Lee-Yuh Palamarchouk, Vitaly S. Palmer, Abraham Palmer, Abraham A. Palmer, Barton W. Palomo, Tomas Panagides, John Panchalingam, K. Pandey, Ghanshyam Pandey, Ghanshyam N. Pandina, Gahan 125, 146 121 68, 81 132 89 138 121 109 98 96 91 102 105, 132, 112 150 132 31 120 121, 125, 130 96 111 135 146 125 106 132 114 93, 107 148 153 138 97 111 24 134 106 100 100 140 98 125, 154 106 Author Index 11/17/05 7:49 AM Pandina, Gahan J. Pangalos, Menelas Pangalos, Menelas N. 148 Panza, Katie Papakostas, George I. Pariante, Carmine M. Parker-Zavod, Erika Parnas, M. L. Parsey, Ramin V. 139 Parylak, Sarah Pascual, Ana Pascual, JC Patel, Jayendra K. Patel, Nick C. Patel, Raman Paterson, Neil E. Patkar, Ashwin A. Patterson, Paul Paul, Steven Paulus, Martin P. Pava, Joel Pavuluri, Mani Pavuluri, Mani N. Payne, Victoria Paz, Rodrigo Pearson, Jane Pedersen, Ron Peindl, Kathleen Peloian, John H. Penengo, MM Penetar, David Peoples, Laura Perahia, David G. Peralta, Jaun Manuel Perera, Tarique Perera, Tarique D. Perez, Victor S. Perich, J. Perkins, Diana Perrone-Bizzozero, Nora Perrotti, Linda Persky, Michael Peschardt, Karina Page 211 109, 124 24 90, 126, Peters, Jeffrey L. Petersen, Timothy J. Peterson, Bradley S. Peterson, Michael J. Pettegrew, Jay W. Pezawas, Lukas 141 Pfefferbaum, Adolf Phan, K. L. Phan, K. Luan Phan, Kin L. Phillips, Ann Phillips, Katharine A. Phillips, Mary L. Phillips, Tamara J. Picchini, Alyssa M. Pickar, David Pierre, Joseph M. Piesla, Michael Pihl, Robert O. Pikalov, Andrei 152 Pilar, Lim Pillay, Srinivasan Pilowsky, Daniel J. Pinard, Gilbert Pindborg, Lars Pine, Daniel Pine, Daniel S. 142 Pinho, Maria Piot-Grosjean, Odile Pitman, Roger Pitman, Roger K. Pitts, Cornelius D. Piven, Joseph Pizzagalli, Diego Platt, Donna M. Plaza, P. Plotsky, Paul M. Polcari, Ann Polesskaya, Oxana O. Poling, James Pollack, Mark H. Pollock, Bruce 155 126 109 122 134 121, 135, 112 100 141 105 126 148 135 123 36 39 139, 140 93 125 139 97 102 49 122 123 132 141 117 57 95 105 25 126 141 141 127, 130 102 115 126 99 211 147 93 155 132 140 120, 127, 90 138 117, 137 108 115 141 141 134 121 126 132 148 113 131, 143, 130 47 99 95, 116 119 45, 99 96, 117, 107 101 117 96, 143 144 116, 119 35 142 141 109 141 150 112 118 90 Author Index 11/17/05 7:49 AM Page 212 Pollock, Jonathan 65 Polzer, John P. 95 Pong, Kevin 109 Poole, Sabrina 137 Pope, Harrison G. 107 Popoli, Maurizio 69 Porcu, Patrizia 113 Porjesz, B. 134 Porter, Richard 54 Posey, David J. 115 Potenza, Marc N. 142 Potkin, Steven G. 100, 154, 155 Potter, William 39 Poulin, Julie 147 Prakash, A. 110 Prasad, Harish C. 115 Prasad, Konasale M. 147 Pratap, Mali 139 Pratt, Jeremy 101 Prescot, Andrew P. 120 Price, David A. 107 Price, Julie C. 116, 118, 124, 138, 139 Price, Lawrence 145 Price, Lawrence H. 114 Price, R. Arlen 103 Prieto, David 100 Pritchett, Yili L. 107 Prudic, Joan 96 Puigdemont, D. 141 Pulicicchio, Claudine 126 Pultz, Joseph 131, 143, 152 Purselle, David 121 Pustavoitau, Aliaksei 118 Qaadir, Asfia 134 Qiang, Mei 136 Quesenberry, Charles P. 101 Quirk, Gregory 84 Quiroz, Jorge A. 123 Radant, Allen D. 105 Radel, Jeffery D. 122 Radulovic, Jelena 154 Ragland, John D. 147 Raison, Charles L. Rajarethinam, RP Rama, Arjune K. Ramamoorthy, Siva Ramsey, Dave Rao, Jagadeesh S. Rao, Uma Rapoport, Judith 105 Rapoport, Stanley I. Rasenick, Mark Rasenick, Mark M. Rasgon, Natalie Rasgon, Natalie L. Raskind, Murray Rasmussen, Hans Rasmussen, Kurt Rauch, Scott Rauch, Scott L. Raventos, Henriette Rawlings, Robert Rech, Richard Redish, A. David Redwine, Jeffrey M. Reed, Bruce Reeves, Scott T. Reich, W. Reinhart, Peter H. Reisberg, Barry Reiss, Allan Reist, Chris Reite, Martin Reite, Martin L. Ren, Xinguo Ren, Zhaoxia Ren-Patterson, R. Ren-Patterson, Renee Renshaw, Perry F. 134 Revicki, D. Reyes, Eduardo Reyes, Magali Reyes, Niko Reynolds, Charles F. Reynolds, Margaret F. 212 109 147 101 126, 148 131 154 142 37, 81, 139, 154 50, 69 98 95 142 79 119 147 47, 84 118 105 136 124 52 90 89 106 134 90 90 97 148 148 139 98, 125 137 151 149 120, 132, 131 147 109 123 124 142 Author Index 11/17/05 7:49 AM Ribeiro, Saulo Rice, John Rice, Kenner C. Rich, Brendan A. 142 Richards, Michele R. Richards, Misty Richardson, Heather Richelson, Elliott Richtand, Neil M. Richter, Margaret A. Ridder, Stephanie Risbrough, Victoria Risbrough, Victoria B. Rivier, Catherine L. Rizavi, Hooriyah S. Robbins, Trevor Roberson-Nay, Roxann Robert, Forman Robert, Mach H. Robert, Zucker A. Roberts, Angela Roberts, James L. Robertson, A. S. Robertson-Plouch, Carol Robichaud, Al Robinson, Benjamin M. Robinson, Delbert G. 151 Robinson, Donald S. Robinson, Jim Robinson, Michael J. Robinson, Terry Rodd, Zachary A. Rodolico, John Rodriguez, Stephen Rodriguez, Steve Rodriguez, Steven Roehrs, Timothy Rogacki, Nancy Rogers, Laura S. Rohrer, Susan P. Rohsenow, Damaris Rojas, Don Rojas, Donald C. Page 213 146 124 113 96, 117, Role, Lorna Rollema, H. Rollis, Denise Rosa-Neto, Pedro Roseboom, Patrick H. Rosen, Amy S. Rosenbaum, Jerrold Rosenblum, Leonard A. Rosenheck, Robert Rosenkranz, Amiel Rosenstein, Donald Rosenthal, Norman R. 143 Rosenzweig-Lipson, S. Rosillon, Dominique Rosso, Isabelle Roth, Bryan Roth, Thomas Rothman, Richard B. Rotrosen, John Rowlett, James K. Roy, Alec Roy-Byrne, Peter P. Rubens, Robert Rubinow, David Rujescu, Dan Ruparel, Kosha Rupp, Claudia I. Ruppert, Andreas Russo, Christie Ryan, C. E. Ryder, Sean Rypma, Bart Saad, Ziad S. Saavedra, Juan M. Sacco, Kristi A. Sacheim, Harold Sacher, Julia Sachs, Gary Sackeim, Alexander Sackeim, Harold A. Sahakian, Barbara Saikali, Khalil Saint Marie, Richard L. Salzman, Carl 97 139 134 67 135 95 120 64 142 134 125 42, 72 117 137 138 119 45 107 148 122, 151 109 131 129, 148, 142 92 107 80, 93 135 117 104, 107 105 106 136 101 113 97 114 148 139 213 65 148 96 95 121, 142 95 143 114 55, 62 148 49, 79 107, 108, 126, 148 104 132 50, 153 97, 109 97 92, 134 142 92 143 97 49 109 128 151 109 90 122 131 140 120 143 105 126 145 122, 143 126 96 35 94 149 28 Author Index 11/17/05 7:49 AM Sambataro, Fabio 138 Sambunaris, A. Samuelsson, Mats Sananbenesi, Farahnaz Sanchez, Yadira Sanders-Bush, Elaine Sangoi, Raj Sano, Mary Sanz, Javier Sassi, Roberto B. Saxena, Kirti Saxena, Sanjaya Saxon, Andrew J. Scahill, Lawrence Schaefer, Catherine A. Schaefer, Desiree M. Schanberg, Saul M. Schapiro, Mark B. Schatzberg, Alan Schatzberg, Alan F. Schechter, Lee Schechter, Lee E. Scheftner, Bill Scheiffele, Peter Scherrer, Jeffrey F. Schiltz, Craig A. Schlaepfer, Thomas E. Schloesser, Robert J. Schmahl, Christian Schmajuk, Mariana Schmid, Wolfgang Schmidt, Mark Schmithorst, Vince Schneider, Lon Schoepp, Darryle D. Schooler, Nina Schooler, Nina R. Schork, Nicholas J. Schreffler, Erica R. Schrick, Christina Schulkin, Jay Schultz, Robert T. Schulz, Charles Schulz, S. C. Page 214 90, 116, Schutz, Gunther Schwandt, Melanie Schwandt, Melanie L. Schwartz, Kelly Schwarzmann, Lesley K. See, Ronald E. Segal, David S. Segman, Ronen Segman, Ronnen H. Sei, Y. Sei, Yoshitatsu Seillier, Alexander Seitz, Patricia K. Self, David W. Semenova, Svetlana Sen, Srijan Seraji-Bozorgzad, Navid Sethuraman, Gopalan Sevak, Rajkumar Sevy, Serge 151 Shah, Kamini R. Shaham, Yavin Shahid, Mohammed 152 Shalev, Arieh Y. Shalom, Galit Shampine, Lawrence J. Sharma, Rajiv P. Shaw, Philip Shear, Paula K. Sheehan, David V. Sheikh, Javaid Sheikh, Nabila Shekhar, Anantha Sheline, Yvette Sheline, Yvette I. Shelton, Richard C. Shen, Joan Shen, Pei-Hong Shen, Shuyi Sher, Leo Shiffman, Saul Shilling, Paul Shilling, Paul D. 110 125 154 130 132 103 89 100 140 97 143 112 66 101 144 109 139 46 106, 122 126 109 124 65 142 135 143 121 119 96 120 39 94 62 108 148 148 105 91 154 115, 118 140 151 152 214 120 115 92, 135 107 143 94, 135 149 125, 143 149 151 149 107 111 91 135 96 118 126 93 129, 148, 142 80 108, 151, 143 125 89 105 37, 115 99 99 89 149 149 139 138 119, 143 151 137 107 135 71 104 149 Author Index 11/17/05 7:49 AM Shim, Seong Shoaf, Susan Shoemaker, Jody M. Sholar, Michelle B. Shorman, Igor Shrivastava, Ram K. Shrivastava, S. P. Shungu, Dikoma C. Sibille, Etienne Sibley, David R. Sibon, Igor Sicard, Tricia Siegel, Arthur J. Siegel, Steve Siegel, Steven J. Siegle, Greg Siegler, Ilene Siegler, Ilene C. Siever, Larry 58 Siever, Larry J. Siever, LJ Silbersweig, David Sills, Terry Silveri, Marisa Silverman, Jeremy Simmons, Julian Simmons, Rosa M. Simmons, Tracy Simpson, George Simpson, Norman Singh, Jaskaran Sinha, Rajita Sircar, Ratna Siris, Sam Sitzer, David I. Siu, Cynthia Skudlarski, Pawel Skupny, Alicja Slawecki, Craig J. Sliwerska, Elzbieta Smagin, Gennady N. Small, Gary Small, Joyce Smith, A. R. Page 215 144 92 149 111, 114 114 144 144 128, 137 90 154 116 95 111, 114 126 149 141 133, 146 109 24, 25, 42, 138 118 47 99 132 114 138 107 93 105 121 146 71 135 104 151 129, 154 104 111 136 119 111 34 131 106 215 Smith, Ashley K. Smith, Eric L. Smith, Gwenn Smith, J. K. Smith, Kelli E. Smith, Lisa J. Smith, Robert C. Snaterse, Mark Snow, Diane Snyder, Avi Snyder, Doug Soares, Jair Sofuoglu, Mehmet Sokolov, Boris P. Solomon, D. A. Sookman, Debbie Soorya, Latha Sorensen, Jill Soto-Perello, Jose Spanagel, Rainer Specker, Sheila M. Spencer, Thomas Spencer, Thomas J. Spiegel, David Spielman, Daniel Spindelegger, Christoph Spinelli, Simona Sporn, Alexandra Sprock, Joyce Srivastava, Lalit Stack, Gary Stahl, Stephen M. Stanford, Arielle D. Stanford, Kevin Stanford, Kevin E. Stanga, Zeno Stanley, Barbara H. Stanley, Jeffrey A. Stead, John D. Steadman, Timothy Steffens, David C. Stein, Joel Stein, Murray B. Steinberg, Joel L. Stenzel-Poore, Mary 130 114, 137 90 114 96 106 149 150 123 139 38 140 112 150 122 95, 116 115 39 148 76 113 78 134 91 97 145 115 105 101, 129 41 126, 148 144 150 135 94, 126 143 125 140 97 149 89 153 139, 140 111, 144 142 Author Index 11/17/05 7:49 AM Stephan, Dietrich Stepien, I. Stern, Jessica Stevens, Rachel Stewart, Daniel G. Stigler, Kimberly A. Stolinski, Lisa R. Stone, William S. Stout, Robert L. Strakowski, Stephen Strakowski, Stephen M. 117, 126, 144 Straub, Richard 152 Straub, Richard E. 150 Stringer, Elizabeth Strode, Nicole L. Baganz Sturm, Volker Su, Jing Subhash, Aryal Sukhodolsky, Denis Sullivan, Edith V. Sullivan, Susan K. Sumner, Jennifer Sunderajan, Prabha Sunderland, Trey 44 Suomi, Stephen J. 109, 113, 115, 135 Suppes, Trisha Sureddi, Suresh Suresh, Rathi Surguladze, Simon Surwit, Richard S. Suslow, Thomas Susser, Ezra S. Sust, Steven 140, 152 Sutcliffe, James S. Sutherland, Ashley N. Sutton, Virginia K. Suyenobu, Brandall Suzuki, Kastuji Svarer, Claus Page 216 86 154 89 101 140 115 146 105 141 56 94, 99, 25, 141, 127, 141, 119 93 143 90 139 155 90 142 115 121 26, 27, 34, 92, 95, 123 123 134 141 109 98 101 102, 116, 115 150 126 138 98 119 216 Svensson, Torgny Svensson, Torgny H. Swain, James E. Swann, Alan C. Swanson, Chad J. Swanson, James M. Swedish, Kristin Sweeney, John A. Sweet, Lawrence H. Swerdlow, Neal Swerdlow, Neal R. 150 Swift, Robert Swift, Robert M. Swyzen, Wim Szabo, Sandor Szalayova, Ildiko Szeszko, Philip R. Szulc, Kamila Szumlinski, Karen Szumlinski, Karen K. Tai, T.C. Talan, Jamie Talavage, Thomas Talbot, Peter S. Talbot, PS Talkowski, Michael E. Talledo, Jo A. Talmage, David Tambini, Arielle Tamminga, Carol Tamminga, Carol A. Tamura, Roy N. Tan, Hao Y. Tan, Hao Yang Tan, Hao-Yang Tan, Yun L. Tancer, Manuel E. Tang, Cheuk Tang, Min Tang, Yilang Tarazi, Frank Tarazi, Frank I. Tariot, Pierre Tauscher, Johannes 150 130 140 111, 144 96, 144 111 89 139 136 101 105, 149, 61, 114 112, 136 130 148 97 102, 151 103 24 151 108 40 116 129 118 147 150 63 102 29, 142 129, 150 108 140 152 102 153 136 140 99 92 92 151 62, 91 145 Author Index 11/17/05 7:49 AM Taylor, Benjamin Taylor, Cindy Taylor, Joy Taylor, Kristin Taylor, Robert E. Taylor, Stephan Taylor, Stephan F. Teale, Peter Teicher, Martin H. Telang, Frank Terrace, Herbert S. Terranova, Jean-Paul Thakkar, Vatsal Thase, Michael E. 122, 141, 145 Thiele, Todd Thomas, A. Thomas, Binu Thomas, Mary L. Thomas, Steven Thomas, Suzanne Thomas, Yonette Thompson, Paul M. Thomsen, Morgane Ticku, Maharaj K. Tidey, Jennifer Tiefenbacher, Stefan Tillemans, Monique P. Tin, Adrienne Tinklenberg, Jared R. Tirado, Carlos F. Toalston, Jamie E. Todorov, C. Todtenkopf, Mark S. Tohen, Mauricio 151 Tokarczyk, Jan Tollefson, Gary Tollefson, GD Tomasi, Dardo Tomita, Hiro Tomoda, Akemi Tone, Andrea Tononi, Giulio Tornatzky, Walter Page 217 135 126 89 115 136 140 118, 137 139, 148 141 111 123 121 143 98, 99, Torossian, Carol Trapp, Bruce D. Treiber, Kristina Tremblay, Jacques Tremblay, Philippe Trisdorfer, Roanna Trivedi, Madhukar H. 145 Trotman, Louis Truesdale, Matthew Tsai, Guochuan E. Tse, Maric T. Tsopelas, Nicholas Tsou, Pon Tsuang, Debby W. Tsuang, Ming T. Tucker, Vivan L. Tummala, Raj Tunbridge, Elizabeth Tunbridge, Elizabeth M. Turetsky, Bruce I. Turkoz, Ibo Turkoz, Ibrahim 124 Twamley, Elizabeth W. Tyrka, Audrey R. Uhart, Magdalena Uhde, Thomas W. Ujike, Hiroshi Ungerleider, Leslie Upadhyaya, Ameet Upadhyaya, Himanshu Upadhyaya, Margi Urani, Alexandre Vaidhyanathaswamy, S. Vakkalanka, Radha K. Vakkalanka, R. Valdes, Ignacio Valdez, Jeffrey N. Valente, Elizabeth Valuck, Robert J. Van Ameringen, Mickael Van Den Buuse, M. Van der Veen, Jan W. Van Heertum, Ronald L. 53 94 150 111 78 93 92 140 92 136 114 142 150 125 89 136 135 95 97, 136 99, 122, 126 91 110 111 145 141 28 132 92 217 90 23 124 96 95 138 121, 122, 123 123 147 126 139 147 147 107 126 123, 145 25, 151 149 151 106 95, 105, 151 114, 145 146 123 51 45 147 93 147 120 149 150 127 111 147 141 145 122 51 137 121 Author Index 11/17/05 7:49 AM Van Kammen, Daniel P. Vance, Jeffery Vapnik, Tanya Vargas, Gabriel Vasquez, Delia Vaughan, Roxanne Vawter, Marquis P. Vecsey, Chris Veenstra-Vander Weele, J. Velligan, Dawn Velligan, Dawn I. Vera, Elizabeth Verbitskaya, Elena V. Verbitsky, Miguel Verchinski, Beth A. 141 Verdeli, Helena Vermetten, Eric Versavel, Mark Vesta, Yethiraja Videbaek, Charlotte Vieta, Eduard Villafuerte, Sandra M. Vincow, Evelyn Vinogradov, Sophia Vinton, Deborah T. Viviano, Tom Voet, Hubertus H. Voglmaier, Susan Vogt, Jerry Volkow, Nora D. Vollenweider, Franz Von Zastrow, Mark 151 Vosburg, Suzanne K. Votaw, John R. Voytek, Bradley Vythilingam, Meena Wadenberg, Marie-Louise Wadsak, Wolfgang Wager, Tor D. Wagner, Angela Wagner, Christopher Wagner, Karen Wagner, Tara Page 218 147 146 96 151 97 134 145 153 134 100 152 144 112 134 116, 127, Walker, Glenn B. 152 Walker, John 131 Walker, Mary M. 96, 144 Walker, Quentin D. 112 Walkup, John 66 Walline, Crystal C. 91 Walsh, B. T. 107 Walsh, David M. 145 Walsh, James K. 109 Walton, Kimberly 136 Wand, Gary 146 Wang, Dayong 90 Wang, Gene-Jack 141 Wang, Jun-Sheng 103 Wang, Liqun 120 Wang, Mei 152 Wang, Wei V. 151 Wang, Yang 116 Wang, Yun 98 Ward, Herbert E. 95 Warner, Virginia 99 Warren, Kenneth 137 Warren, Stephen 83 Warrington, Lewis 129 Wasserman, Stacey 115 Wassink, Thomas H. 116, 127 Watkin, JG 110 Watkins, Lana 97 Watner, Dryden 114 Watson, Adam 132 Watson, Stanley 97 Watson, Stanley J. 93, 145 Watts, Val J. 154 Waugh, Christian E. 140 Webster, Maree J. 101 Wedig, Michelle M. 118 Weickert, Cynthia 63 Weickert, C. S. 101, 102 Weilburg, Jeffrey B. 152 Weiler, Martin A. 129 Weinberger, Daniel 29, 30, 40, 42, 63, 152 Weinberger, Daniel R. 40, 90, 102, 116, 120, 127, 137, 138, 140, 141, 149, 150, 151, 152 99 119, 145 103 114 119 48 145 141 152 117, 142 149 149 154 153 111 72 33, 69, 112 112 95 99 150 145 140 116 97 122 128 218 Author Index 11/17/05 7:49 AM Weiner, Michael Weinshenker, David Weinstein, Mitchell Weiss, Anthony P. Weiss, Friedbert Weiss, Susan Weissfeld, Lisa A. Weissman, Myrna M. Welch, Ron Wells, Barbara Welsh, Robert C. Wernicke, Joachim F. Wesnes, Keith A. Wess, Juergen Wessel, Thomas West, Britt Westenberg, Herman Westenberg, Herman G. Wetterberg, Lennart White, Tara L. White, Tonya Whitfield, Susan L. Whitsel, Rachel Whybrow, Peter C. Wickramaratne, Priya Wiegand, R. Wiegand, Ryan E. Wier, Lauren Wilhelmsen, Kirk C. Wilkins, Consuelo Williams, Mark J. Williams, Michael Williams, Redford Williams, Redford B. Williams, Wendol A. Williamson, Douglas Winsky, Lois Wint, Dylan Wirshing, Donna A. Wirshing, William C. Wisner, Katherine L. Wisniewski, Stephen Wisniewski, Steven Wittchen, Hans-Ulrich Woerner, Margaret Page 219 89 31 106 152 57, 71 80 139 99, 137 150 111 118 98, 107 109 92 97 131, 152 119 145 104 136 152 104 144 95 99 134 115 114 93 139 91 109 133, 146 109 136 99 36 152 132 132 138 122 122 95 148 Woerner, Margaret G. Woertwein, Gitta Wohlreich, MM Woldbye, David P. Wolf, Dan Wolf, Fred Wolinsky, Toni D. Wong, Dean Wong, Dean F. Wong, Dona Lee Wong, Erik Wong, Erik HF Wong-Faull, David C. Wood, Marcelo A. Wood, Ruth Wood, Suzanne E. Woodgett, Jim Woods, Scott W. Woody, George E. Woolston, Dixie J. Woolwine, Bobbi J. Wozniak, David Wozniak, Janet Wozniak, Jeffrey R. Wright, Christopher I. Wright, Ron Wu, Chi-Cheng Wu, Jingwei Wu, Min Wu, Nan-Ping Wu, T. John Wu, Xiaoling Xian, Hong Xiang, Jim Xu, Haiyun Xu, Ke Xu, Wen Xu, Zhi-Qing D. Yale, Scott Yamada, Kiyofumi Yamamoto, Tsuneyuki Yan, Bing Yang, Ruoyong Yang, Xiaoju Yang, Yili 219 129 92 110 92 147 103 96 66 39, 119 108 152 151 108 153 43 118 60 130 112, 137 144 109 104 122 113 118 107 90 116 153 108 89 130 142 143 129 129, 137 122, 151 144 128 51 137 122 148 146 147 Author Index 11/17/05 7:49 AM Yap, Jasmine J. Yaw, Senyah Yehuda, Rachel 143 Yesavage, Jerome A. Young, Elizabeth A. 146 Young, Larry Young, Simon N. Youngstrom, Eric A. Yu, Yang Yuan, Qiaoping Yurgelun-Todd, Deborah Yurgelun-Todd, D. A. Zacher, Christiane Zacny, James Zajac-Benitez, Caroline Zaleska, Margaret Zandi, Peter Zappert, Laurel N. Zarate, Carlos Zarate, Carlos A. Zavadoski, W. J. Zboyan, Holly Zelazny, Jamie Zhang, Hanting Zhang, Jean Zhang, Lei Zhang, Wei Zhang, Xiang Y. Zhang, Xuexiang Zhang, Ying Zhao, Y. Zhao, Zaorui Zheng, Kang Zheng, Ling Zhong, Huailing Zhou, Dong F. Zhou, Xianjin Zhou, Yuan Zhu, Baojin Zhu, Haojie Zhu, Wei Zhu, Young Zielinski, Tanya Page 220 124 101 74, 125, Zink, Mathias Ziolko, Scott K. Zisook, Sidney Ziwich, Rachel Zoltick, Brad Zorn, Stevin Zou, Mu-Fa Zubenko, George Zubieta, Jon-Kar Zuchner, Stephan Zvartau, Edwin E. 89 106, 145, 83 113 146 128 137 95 132, 137 120 85 123 109 124 142 27 146 148 123 125 146 126 111, 146 97 153 144 99 131 125 144 89 144 153 116 90 100, 103 103 90 98, 101 91 220 120 124, 139 79 102 140 152 134 34, 44 85, 119 133, 146 112 MAPS 2006.qxp 11/17/05 7:50 AM Page 221 MAP 69' x 36' Kohala 1 BOARDROOM Lagoon Lagoon Lanai 35' x 55' 28' x 36' Kona 2 Kona 3 21' x 36' 222 Waikoloa Suites Waikoloa 1 Waikoloa 2 Waikoloa 3 31' x 23' 31' x 23' 31' x 23' 30' x 36' Kona 1 80' x 36' Kona 4 80' x 36' Kona 5 Kona Ballroom Grand Staircase up To Main Lobby 7:50 AM LOUNGE Queen's 4 35' x 55' 36' x 55' King's 1 Queen's 5 37' x 55' Queen's 6 36' x 55' Grand Promenade 95' x 134' King's 2 37' x 55' Monarchy Function and Meeting Space 11/17/05 69' x 36' Kohala 2 69' x 36' Water’s Edge Ballroom King's 3 120' x 206' 69' x 36' Kohala 3 Grand Ballroom HILTON WAIKOLOA VILLAGE Kohala 4 Kohala Ballroom MAPS 2006.qxp Page 222 MAPS 2006.qxp 11/17/05 7:50 AM Page 223 223 MAPS 2006.qxp 11/17/05 7:50 AM Page 224 Future ACNP Annual Meetings Dates Hotel Location December 3 - 7, 2006 December 9 - 13, 2007 December 7 - 11, 2008 The Westin Diplomat Boca Raton Resort & Club The Fairmont Scottsdale Princess Hollywood, Florida Boca Raton, Florida Scottsdale, Arizona Summary Program Event Time Location Saturday, December 10, 2005 On-Site Registration Pre-Paid Registration 10:00 am - 6:00 pm 10:00 am - 6:00 pm Kona 3 Outside Waikoloa 1 Sunday, December 11, 2005 On-Site Registration Pre-Paid Registration Teaching Day Hot Topics Oakley Ray History Lecture 7:00 am 7:00 am 8:00 am 2:30 pm 7:00 pm - 5:00 pm 5:00 pm 12:30 pm 5:00 pm 8:00 pm Kona 3 Outside Waikoloa 1 Monarchy Ballroom Kona 4 & Kona 5 Kona 4 Monday, December 12, 2005 On-Site Registration Pre-Paid Registration Awards Presentation President’s Plenary Poster Viewing Distinguished Lecture Panel Sessions Poster Session I Issue Oriented Study Groups 7:00 am 7:00 am 8:00 am 8:30 am 10:30 am 1:00 pm 2:30 pm 5:30 pm 7:45 pm - 5:00 pm 5:00 pm 8:30 am 11:30 am 4:30 pm 2:15 pm 5:00 pm 7:30 pm 9:00 pm Kona 3 Outside Waikoloa 1 Monarchy Ballroom Monarchy Ballroom Kohala Ballroom Monarchy Ballroom See Program Book Kohala Ballroom See Program Book Tuesday, December 13, 2005 On-Site Registration Pre-Paid Registration Panel Sessions Poster Viewing Issues in Ethics Panel Sessions Poster Session II 7:30 am - 5:00 pm 7:30 am - 5:00 pm 8:00 am - 10:30 am 10:30 am - 4:30 pm 12:00 pm - 2:30 pm 2:30 pm - 5:00 pm 5:30 pm - 7:30 pm Kona 3 Outside Waikoloa 1 See Program Book Kohala Ballroom Monarchy Ballroom See Program Book Kohala Ballroom Wednesday, December 14, 2005 Town Hall: Clinical Trials Registry Registration Panel Sessions Poster Viewing Business Meeting (Members Only) Memorial Symposium Panel Sessions Poster Session III 7:00 am 7:30 am 8:00 am 10:30 am 10:45 am 1:00 pm 2:30 pm 5:30 pm - Kona 4 Kona 3 See Program Book Kohala Ballroom Kona 4 Queen’s 6 See Program Book Kohala Ballroom Thursday, December 15, 2005 Registration Panel Sessions Teaching Neuropsychopharmacology Panel Sessions Reception 7:30 am - 3:00 pm 8:00 am - 10:30 am 12:30 pm - 2:00 pm 2:30 pm - 5:00 pm 7:30 pm - 10:30 pm Kona 3 See Program Book Kona 5 See Program Book Monarchy Ballroom ACNP Service Center Saturday (registration only) Sunday-Monday Tuesday-Wednesday Thursday 10:00 am 7:00 am 7:30 am 7:30 am - 6:00 pm 5:00 pm 5:00 pm 5:30 pm Kona 3 Kona 3 Kona 3 Kona 3 ACNP Computer Center Sunday-Wednesday Thursday 7:30 am - 9:00 pm 7:30 am - 5:00 pm Kona 2 Kona 2 8:00 am 5:00 pm 10:30 am 4:30 pm 11:45 am 2:15 pm 5:00 pm 7:30 pm ACNP Executive Office • 545 Mainstream Drive, Suite 110 • Nashville, TN 37228