Example Scenarios

Biological Data in canSAR
Bissan Al-Lazikani
Mark Halling-Brown
Cancer
Therapeutics
Unit
Example Scenarios
•  We have a new target of interest and would like to
view a summary of known information (E.g. CYP19A).
- What cell line is it expressed in?  hypothesis
test system
- Are there tool compounds that I can screen in
these cell lines?
•  I have a target of interest, it is not suitable for
progressing further. Is there a better target in its
interaction network? (E.g. FRS2)
Example Scenarios
•  Accessing public Cell line screening data
•  I am interested in screening a target, what other
targets are likely to bind the same compounds? E.g.
Cyp19A
•  I have a siRNA hit lists and would like to explore
known data and prioritise these hits
canSAR Menu
Example Scenarios
•  We have a new target of interest and would like to
view a summary of known information (E.g. CYP19A).
Search
Keyword
View Target
Synopsis
View
Expression
Data
Export Data
Filter
Bioactivity
Data
Inspect
Bioactivity
Search Results (CYP19A)
Target Synopsis (CYP19A)
Known Drugs (CYP19A)
Screening Data (CYP19A)
Expression Data (CYP19A)
Family Network (CYP19A)
Interaction Network
Explore Bioactivity Data (CYP19A)
Explore Bioactivity Data (CYP19A)
Filter Bioactivity Data
Explore Screened Compounds (CYP19A)
Explore Screened Compounds (CYP19A)
Example Scenarios
•  I have a target of interest, it is not suitable for
progressing further. Is there a better target in its
interaction network? (E.g. FRS2)
Search
Keyword
View Interaction
Network (Target
Synopsis)
Inspect
Bioactivities
Export Target
Data
Filter
Bioactivities
canSAR Menu
Search Results (FRS2)
No Screening Data (FRS2)
Interactors (FRS2)
Interactors (FRS2)
Interactors (FRS2)
Interactors (FRS2)
Example Scenarios
•  Accessing public Cell line screening data
Search
Keyword
Filter
Bioactivities
Export
canSAR Menu
Search Celllines
Functional Data
Example Scenarios
•  I am interested in screening a target, what other targets
are likely to bind the same compounds? E.g. CYP19A
Search Keyword
Filter
Bioactivities
Use compounds
to launch new
search
View Bioactivity
Profile
Filter
Bioactivities
Search Keyword (CYP19A)
Filter Bioactivity
Launch New Search from Compounds
Inspect Bioactivities
Filter Bioactivity
View Bioactivity Profile
Bioactivity Profile
Bioactivity Profile
Example Scenarios
•  I have a siRNA hit lists and would like to explore
known data and prioritise these hits
Load List of
targets
Perform
Chemogenomic
analysis
canSAR Menu
canSAR Menu
Load List of Hits
Available Operations from List
Chemogenomic Annotation
Expression Data
Questions/Comments/Request
•  Email [email protected]