the day`s presentations in one PDF - National Treatment Agency for
Transcription
the day`s presentations in one PDF - National Treatment Agency for
Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Evidence into practice and policy: needle and syringe programmes - protecting people and communities Chair’s welcome and overview Dr Paul Cosford, Director for Health Protection and Medical Director, Public Health England Monday 19 May 2014, Birmingham Welcome • Here to support the implementation of an important evidence-based intervention: • Morning session:– the why and what • Afternoon:– the how In the 80s, 90s and 00s, government, services and drug users responded to heroin and crack injecting What do we face now? – A brief overview 3 Needle and syringe programmes - protecting people and communities, 19 May 2014 Significant achievements to maintain and build on Rate of sharing HBV vaccination rate Anti-HCV prevalence Anti-HIV prevalence Anti-HBV prevalence 100% 80% 60% 40% 20% 0% 2002 4 2003 2004 2005 2006 2007 2008 2009 Needle and syringe programmes - protecting people and communities, 19 May 2014 2010 2011 2012 Evidence that IPED injection and infection levels are increasing The most commonly used image and performance enhancing drugs are anabolic steroids. These are typically injected. The 2012/13 Crime Survey estimated that 59,000 people aged 16–59 years had used anabolic steroids in the past year, but emerging consensus that this is an under-estimate. Other drugs used include the tanning agent melanotan. 1.5% are living with HIV 5.5% have been infected with hepatitis C 8.8% have been infected with hepatitis B People who inject image and image and performance enhancing drugs are, in some areas, the largest group making use of needle and syringe programmes. Needle and syringe programmes - protecting people and communities, 19 May 2014 More challenges Changes in psychoactive drug injection New psychoactive substances and club drugs • Evidence of mephedrone and ketamine injecting • International lessons, e.g. injecting synthetic cathinones – like mephedrone – associated with the recent HIV outbreak in Romania Changing patterns of drug use among some men who have sex with men • ‘Slamming’ (injecting drugs) often in the context of ‘sex parties’ • Injecting, often among HIV-positive gay men, heightening concern about the transmission of blood-borne viruses and bacterial sexually transmitted infections (particularly hepatitis C, HIV and Shigella) 6 Needle and syringe programmes - protecting people and communities, 19 May 2014 The operating landscape Local authorities commission NSP from the PH grant • Local decisions based on local need – evidence & assessment of need are vital PHE and NICE • Evidence-based recommendations • Implementation support, including: data standards; briefings for providers and commissioners • Case for investment and return on investment • Relationship to other PHE and NICE work • Hepatitis C treatment – access and pathways • MSM sexual health and wellbeing • Evidenced based commissioning and service provision • Balanced recovery oriented treatment systems- balanced and integrated recovery and impact on health harms and need. • Evidence-based briefings on IPEDs, MSM, BBV transmission 7 Needle and syringe programmes - protecting people and communities, 19 May 2014 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Keynote address: 30 years of needle exchange Lord Norman Fowler Former Health Secretary Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Updating the NICE Needle and Syringe Programme (NSP) Guidelines: PH 52 - April 7th 2014 Professor Chris Packham, Core Member, Public Health Advisory Committee A Centre for Public Health Needle and Syringe Programmes • Supporting existing NICE guidance – PH9, PH4, CG52, CG51, several TAs • NSPs protect individuals and communities from the effects of blood borne viruses and other harms associated with injecting drugs • NSP and Opioid Substitution Therapy (OST) hasn’t reduced Hepatitis C prevalence – increased coverage may • NSP is a gateway to wider prevention and treatment • NSPs need to be available in many different settings / times and to many different types of client group • High coverage likely to be very important (>100%) Six original recommendations (PH 18 2009) 1 PLANNING, NEEDS ASSESSMENT AND COMMUNITY ENGAGEMENT 2 MEETING NEED 3 TYPES OF SERVICE: 3 TIER MODEL OF NSP PROVISION 4 EQUIPMENT AND ADVICE 5 COMMUNITY PHARMACY-BASED NSPs 6 SPECIALIST NSPs: LEVEL THREE SERVICES Plan • Rationale for the update • How the updated guidelines were developed • Changes from the original guidelines • Remaining gaps Process • Guideline PH18 published Feb 2009, review Apr 2012 • Expert group considered whether any new evidence or significant changes in policy and practice would be likely to lead to substantively different recommendations • The proposal of the expert group was consulted on publicly • Findings – There was no new evidence to contradict the current recommendations – There was new evidence that could add to existing recommendations – There was new evidence that could expand the previous work to more fully meet the scope New areas • NICE decided to undertake an update of the existing NSP guidelines • Following the expert group and consultation, the update focussed on: – New evidence related to existing recommendations • Vending machines, outreach, drop boxes. – NSP provision to Image and Performance Enhancing Drug (IPED) users – NSP provision to under 18s Preparing the review Centre for Public Health commissioned reviews of the evidence – Quantitative and qualitative review of evidence since 2008: • • – – What level of coverage, type of NSP and alternative services are most effective and cost-effective in reducing the prevalence of BBV, deaths and morbidity qualitative evidence: what do users and professionals identify as suitable types of NSPs, suitable level of coverage of equipment, views and perspectives on NSPs, additional harm reduction services and OST delivered in parallel or alongside NSPs – Young persons (<18) use of services Policy review and Consensus development using panel of 12 experts on optimal provision of services for <18s Image and Performance Enhancing Drugs (IPEDs) review – Fieldwork results and summary of stakeholder comments How the Public Health Advisory Committee (PHAC) works • Evidence searches determined by initial expert group and public consultation • PHAC then considered that evidence – Core members (chair, systematic reviewer, public health, psychology, statistics, economics, lay) – Topic Experts – Academic teams who produced the Evidence – 2 meetings to produce then fieldwork / stakeholder views on drafts – Final meeting – production - consultation – publication Deliberations • Wide range of facts and issues from initial evidence update and expert comments: – – – – – Public perceptions of drop boxes Aspects of improving data collection Training issues in extending NSPs to under 18s Switching from injecting not always a safer option The heterogeneity of risk across different IPED user groups Whats new? • Original PH18 had six recommendations – PH 52 has 10 • Two completely new recommendations: – Under 18s – IPEDs • Two expansions of existing recommendations – Collation of data on drug use – monitoring of services Develop a policy for young people aged under 18 • • • • Requires local areas to develop and implement a policy on providing NSP and related services to young people aged under 18 (including young people under 16). Asks how local services will achieve the right balance between the imperative to provide young people with injecting equipment and the duty to safeguard them and provide advice on harm reduction and other services. It includes: – the young person’s capacity to consent – the risks they face – the benefits of them using services – the likelihood that they would inject anyway, even if equipment was not provided. Provide NSP as part of a package of care (esp to under 16s) where possible. Offers some ideas about the things local areas will need to consider, for example consent, parental involvement, specialist substance misuse services for YP, training needs Provide equipment and advice to people who inject IPEDs • Ensure needle and syringe programmes: – Are provided at times and in places that meet the needs of people who inject IPED. (For example, outside normal working hours or outreach in gyms.) – Provide the equipment, information and advice needed to support these users. – Are provided by appropriately trained staff • Specialist NSPs with high numbers of IPED users should provide specialist services for them. It includes: – specialist advice about IPED and side effects – advice on alternatives (for example, nutrition and physical training as an alternative to Anabolic Steroids) – information about, and referral to, sexual and mental health services and to specialist IPED clinics, if these exist locally. Notable additions • “Not discourage secondary distribution” • “Where possible, provide low dead space syringes” • Consider drop boxes (in consultation with police and communities) • Consider whether vending machines might be appropriate Considerations • NSPs must be part of comprehensive strategies – vital ‘gateway’ role • Non judgemental about providing NSPs • Most research was USA-based • High coverage (% injections covered by sterile needles) is key • Vending machines for Out of hours or isolated geographical areas but NOT as substitute • Balance between safeguarding and provision for under 18s – good practice to involve Local Safeguarding Board advice • Some instability of the original heath economic model • Lower marginal costs for extending NSPs to under 18s • Lack of data for IPED modelling: “insufficient evidence to determine whether it is cost effective to develop dedicated services for this group” Gaps and Research Recommendations • Encouraging NSP use in specific groups • Cost-effectiveness of NSPs for <18s and IPED users • What behaviour-change interventions work apart from ‘clean works’ • What types of injecting equipment best reduce harm • Do NSPs have unintended consequences? – How do disposal facilities affect drug litter – How do NSPs affect use long-term – Do NSPs have negative effects on community perceptions of crime IMPLEMENTATION • revised guidance published 9th April 2014 • Range of tools and support from PHE and NICE [email protected] Louisa Wall, Implementation Advisor [email protected] Costing statement • The statement demonstrates that for a relatively small investment, around £200 per annum for a person who injects drugs, there is the potential to avoid significant future healthcare costs estimated to be between £10,000 and £42,000 per individual, per annum. In addition there may savings in wider societal costs, for example crime costing an average of £26,074 is committed by an addicted person not in treatment. Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Evidence into practice and policy: The potential impact of needle and syringe programme provision on people and communities Matt Hickman – & (Peter Vickerman, Norah Palmateer, Sharon Hutchinson, Esther Aspinal, David Goldberg, Matthew Barber, Angela Beattie, Georgie Macarthur, Natasha Martin, Vivian Hope, Alec Miners, Lucy Platt) Acknowledgements • NIHR Health Protection Research Unit in Evaluation of Interventions • NIHR School of Public Health Research • Health Protection Scotland: HCV Action Plan • NIHR Research for Patient Benefit (RfPB) Programme “Script in a day trial” (PB-PG-0909-20007) & Bristol Drug Project • European Commission Drug Prevention and Information Programme (DIPP) “Treatment as Prevention in Europe: Model Projections of Impact And Strengthening Evidence Base On Intervention Coverage and Effect” • NIHR Health Services and Delivery Research (HS&DR) (12/3070/13) Assessing the impact and cost-effectiveness of needle/syringe provision on hepatitis C transmission among people who inject drugs: an analysis of pooled datasets and economic modelling. • National Institute of Health and Care Excellence: Public Health Guidance 18 Summary • NSP are effective • Good/emerging evidence that reduce injecting risk and BBV transmission • NSP are cost-effective • Strategies to increase high coverage NSP (as low cost) likely to be cost-effective • NSP gateway to other services • Promote OST/ viral testing/ research • NSP are a key component of “comprehensive programme of interventions to reduce injecting risk/ drug related harm Effectiveness:- Review of Reviews NSP is effective in reducing self-reported injecting risk behaviour BUT weak/insufficient evidence on HCV (and HIV) transmission Palmateer et al Addiction 2010 105: 844-59 (http://www.hepcscotland.co.uk/action-plan.html Pooling UK evidence on intervention impact Site Year Design N HCV+ve Incidence Bristol 2006 RDS 299 59% Leeds 2008 RDS 302 60% Birmingham 2009 RDS 310 42% Glasgow 2008-09 C'sectional NSP 947 70% Wales 2004-06 Follow-up 406/700 26% London 2001-02 Follow-up 282/428 43% Turner Addiction 2011 doi: 10.1111/j.13600443.2011.03515.x 40 per 100py 7.6 per 100py 5.2 per 100py 10.0 per 100py 5.6 per 100 py 42 per 100py Seroconversions 14 2 2 6 17 49 OST/HIGH COVERAGE NSP (HC_NSP) EFFECTIVENESS • Use recent pooled UK evidence for impact of harm reduction on an individual’s risk of recent HCV infection1 Effect Estimates AOR1 95% CI HC_NSP 0.48 0.3 0.9 OST 0.41 0.2 0.8 OST and HC_NSP 0.21 0.1 0.5 1 adjusted for: gender, crack, homeless, injecting duration HC_NSP is defined as exchanging more syringes than you inject Turner K et al. Addiction 2011; 106:1978-88 Meta-analysis of studies showing impact of opiate substitution treatment in relation to HIV transmission in people who inject drugs among all pooled studies and studies reporting only adjusted effect estimates . MacArthur G J et al. BMJ 2012;345:bmj.e5945 Results – Intervention to Increase Recruitment (and extend duration) High Coverage NSP Increase in recruitment Cost (£) QALYs ICER 20K* 30K* Baseline 481,129,096 10,563 12.5% 481,248,303 10,566 £38,679 n/a n/a 25% 481,251,065 10,569 £19,864 £1 £62 50% 481,243,248 10,574 £9,848 £118 £234 100% 481,318,473 10,583 £4,359 £321 £526 Decision Problem 2 - What additional cost would be acceptable if it were possible to increase sterile syringe coverage for IDUs attending NSPs? I NICE public health guidance 18 Needle and syringe programmes: providing people who inject drugs with injecting equipment • Ensure services aim to be accessible and: • Increase the proportion of people who have more than 100% coverage (that is, the number who have more than one sterile needle and syringe available for every injection) HCV ACTION PLAN SCOTLAND: HOW HAS INJECTING RISK BEHAVIOUR CHANGED? Slides on hcv action plan • Unpublished data – please contact:• [email protected] • [email protected] Can we attribute changes in HCV and risk behaviour to the Action Plan? Provision/ uptake of sterile injecting equipment Methadone Drug market factors Frequency of injecting Drug use trends HCV testing/ knowledge of HCV status Sharing injecting equipment HCV transmission Education Cessation of injecting/ death/ migration Prevention: Evidence from international studies Intervention Needle/syringe provision (NSP) Opiate substitution therapy (OST), i.e. methadone Outcome Injecting risk HCV behaviour transmission NSP & OST combined Paraphernalia provision + + + = compelling + = tentative +++ + +++ ++ +++ +++ ++ – + + = sound – = insufficient HCV PREVENTION – COMBINED INTERVENTIONS Estimated number of people infected with HCV: E&W ~15,000 White; 11,000 (IPB) Sweeting et al. Biostatistics 2008; De Angelis et al, Statistics in Med Research 2009; Ross et al EJPH 2011 HCV prevalence (baseline was 40% prevalence) Impact of changing coverage of OST and NSP from 50% 80% 70% 60% 50% 40% 30% 20% 10% 0% Without NSP/OST 60% 70% 5 years 80% 60% 70% 80% 10 years 60% 70% 80% 20 years Effect of scaling up both OST and NSP to 60%, 70% and 80% coverage for different durations (baseline was 50% coverage) Vickerman et al Addiction 2012 doi:10.1111/j.1360-0443.2012.03932.x 10 YEAR RELATIVE PREVALENCE REDUCTIONS WITH COMBINING OST/NSP/HCV TREATMENT 40% chronic prevalence • Dark red: modest (<20%) impact, high HCV • Orange: ~50% impact • White: >80% impact • HCV treatment scale-up needed to achieve >40% reduction in 10 years Martin NK, Hickman M, Hutchinson SJ, Goldberg DJ, and Vickerman P. Combination interventions to prevent HCV transmission among people who inject drugs: modelling the impact of antiviral treatment, needle and syringe programmes, and opiate substitution therapy. Clinical Infectious Diseases 2013 NSP – R&D Script in a day (SCID) • An un-blinded parallel-group feasibility RCT of same day access to opioid substitution therapy (OST) compared with standard care with 3 month follow-up. • Injecting drug users presenting for needle exchange at Bristol Drugs Project and not in treatment for at least two weeks were invited to take part. Intervention vs Control • SCID • Drug worker makes appointment at trial GP surgery for same day OST and arranges Peer Support volunteer to accompany them to first and subsequent appointments if wanted. • Seen by GP on day 0, 7, 21 then transferred to Shared Care Worker at their own GP surgery • Treatment as Usual • Case management/ MI • Participant informed how to get OST and free phone call to make own GP appointment. SCID results - unpublished • Please contact:• [email protected] Summary • No evidence of a difference in outcomes between the two groups at 3 months • Days use of opiate use decreased >70% in both groups amongst those on OST • Self-reported health utility improved during trial – but low compared to general population (0.6 vs ~1) & no evidence of a difference between intervention and control Conclusions • Trial success • good recruitment and excellent follow-up • Proposed by users and workers/ PPI • But insufficient evidence of an effect compared to intensive case management. • Qualitative study suggested that completing the baseline questionnaires may help create or improve motivation for treatment. • Evaluate whether more intense case management (with neutral health audit) could increase uptake of OST… Future • Systematic review of effectiveness of NSP & OST on HCV • Update & refine costing of NSP and CE evaluation • Optimise combination of interventions to reduce HCV • Develop & evaluate strategies to improve NSP delivery and reduce drug related harm Amsterdam Cohort Study – impact of harm reduction HIV seroconversion: Harm reduction vs. no harm reduction HCV seroconversion: Harm reduction vs. no harm reduction Van Den Berg et al.. Addiction 102 (9), 1454-1462 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Substance Misuse : Maintaining Public Health Priorities in a time of Diminishing Resources Mind The Gap Cllr Steve Bedser Cabinet Member Health & Wellbeing Health Wellbeing Mind&The Gap Significant change Responsibility for Drug and Alcohol funding moved to Local Authorities in April 2013 Health Wellbeing Mind&The Gap Risk of Disinvestment • Current severe financial pressures on Local Authorities • Realisation of cost efficiencies through integrated commissioning and realising cross cutting outcomes: Adult Substance Misuse and linkages with LAC Police and in cell intervention including substance misuse / mental health and health care Substance misuse detoxification combined with rehabilitation Supporting People and substance misuse provision Health Wellbeing Mind&The Gap HWB Priorities – Substance Misuse Through early intervention / prevention opportunities reducing: • Numbers of LAC • Homelessness • Domestic Violence Health Wellbeing Mind&The Gap The Reality – We Know • Reducing the risk of neglect and abuse of our children who have substance misusing parents is a critical issue for many LA’s. • A very high proportion of families with children who are known to social care have parents with substance misuse or mental health problems Health Wellbeing Mind&The Gap The way forward • Use of new focused support mechanisms • Use of new treatments and commissioning different approaches • Focus detailed, integrated, support for the most vulnerable – timely interventions • Continue our central battle through political representation and advocacy • Working across organisational boundaries and at a local level Health Wellbeing Mind&The Gap Local Government • Still fairly new for Local Government and for local politicians – a very large area of expenditure • Role of corporate and societal culture • Hard choices on best use of public money – not just what, but whom PublicThe Health Mind Gap Key messages • Needle & syringe programmes protect individuals & communities • They were important when HIV threatened in the 80s – and are still critical interventions. • Opiate and crack use, and injecting, may be decreasing but new/growing populations of injectors are emerging: image and performance-enhancing drugs, and new psychoactive substances, men who have sex with men, young people • In some of these populations, BBVs are worryingly high • NSP is also a gateway to treatment (drugs and HCV etc) and recovery • NSP flexibility: both pharmacy and specialist, in gyms, 24-hours, etc • Local authorities need to maintain investment in a context of competing priorities. NSP provides value for money by protecting individual and wider community public health and safety Health Wellbeing Mind&The Gap An example from Birmingham Audit & review: Needle Exchange Services • Distributed without wrap round interventions • Limited focus on harm minimisation • Users are often not supported to access structured treatment services • Anecdotally gym owners sell on needles to steroid users • Feedback from users: Needle exchange packs need reviewing • Expensive and outdated needle exchange packs Action: Now being addressed as part of the recommissioning of substance misuse services in Birmingham Maintaining public health priorities in a time of diminishing resources Martin Reeves, CEO, Coventry City Council Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Panel Discussion Monday 19 May 2014, Birmingham Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham NICE – supporting quality in health and social care Chris Connell Implementation Consultant May 2014 Areas to cover • Why use NICE guidance and quality standards • Support for implementation • Finding what you need quickly and easily So why use NICE guidance? • Comprehensive evidence base • Expert input • Patient and carer involvement • Independent advisory committees • Genuine consultation • Regular review • Open and transparent process. But there are tensions … • Complexity • Costs and funding • Co-morbid conditions • Demographic change • Public expectations • Professional interests And in particular, from the NICE uptake survey of PH18 • • • • • Lack of data – esp. hard to reach groups Difficulty in conducting needs assessment Engagement of some key staff difficult Knowledge gaps – e.g. comm. pharmacy staff. Applying recommendations to young people – half of respondent to survey had not applied the recommendations to young people • Insecure funding – evidencing the return on investment The NICE Implementation Strategy • Developing a supportive environment – Key partners – Education initiatives • Practical tools • Evaluation NICE guidance support • Baseline assessment tool • Costing tools • Commissioning guide • Shared learning case studies • NICE MPC information for community pharmacists • Collaboration with PHE to provide practical support • Data Set – to be published Shared learning case studies Includes examples of: • Community pharmacy based NSPs • Blood borne virus screening and vaccination service • Peer exchange scheme Videos available from NICE website Shared Learning Lifeline Kirklees – Putting the muscle into recovery The Can Partnership PBNX (pharmacy-based needle exchange) programme for community introduction www.nice.org.uk/sharedlearning NICE Field Team • Implementation Consultants • Team of 7 aligned to NHS England regions • 1 in Northern Ireland • Each responsible for a geographical area • Provide local support • Contact details on the map Finding what you need quickly and easily Different ways of finding guidance on the new website NICE Pathways NICE support for local government – on one page www.nice.org.uk/localgovernment How to find out more • Website www.nice.org.uk • Sign up to receive monthly NICE News • Email: [email protected] • Queries email [email protected] • 25,000+ people now follow us on Twitter for guidance updates @NICEcomms Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Panel discussion: NSP implementation from different perspectives [email protected] We believe individuals have a right to be able to access high quality information about drugs and using drugs to enable them to make informed choices about which drugs they use, the positive effects of drugs, the risks of using particular drugs and practical information to enable them to use more safely. We also believe that anyone who feels they need Drug Treatment should be able to access high quality treatment that meets their individual needs. We accept that this treatment may not be the same for everyone and that an individual’s needs may vary over time. Norman E. Zinberg, M.D. Drug, Set and Setting. The basis of controlled intoxicant use. Newhaven and London: Yale University Press, 1984 http://www.exchangesupplies.org/shopdisp_sharp_ needle_blunt_needle_card.php?page=pictures Public Health England, Health Protection Scotland, Public Health Wales and Public Health Agency Northern Ireland. Shooting Up: Infections among people who inject drugs in the UK 2012 (update 2013) London: Public Health England, November 2013 http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317140236856 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Workshop A People who inject image and performance-enhancing drugs Monday 19 May 2014, Birmingham EVIDENCE INTO PRACTICE AND POLICY: NEEDLE AND SYRINGE PROGRAMMES – PROTECTING PEOPLE AND COMMUNITIES 19/05/2014 People who inject image & performance enhancing drugs Anabolic steroids Based on the (male) hormone testosterone More accurately called: Anabolic - muscle building Androgenic - masculinising Steroids *a bit oestrogenic as well What do we actually know about IPED use in the UK? Prevalence Characteristics of users Reasons/drivers for use Drug efficacy & actions Methods & regimes Harms Effective drug prevention Effective harm reduction Very little Some Partial Limited Good Patchy Minimal Developing + ++ ++ + +++ + + ++ IPED Psychoactive drugs Used to change physical appearance or improve performance / strength Used to effect mood or perception. Usually planned on/off cycles Often uncontrolled and habitual No evidence of drug driven crime but some association with violence Strong link with acquisitive crime Ampoules of liquid or vial of powder for reconstitution Powders or tablets which need to be prepared for injection Mostly bought through the internet, in gyms or imported Acquired on the ‘street’ Injected IM or SC Usually injected IV Frequency of injection usually between daily - weekly Often multiple injections daily Increasing numbers of users Decreasing prevalence (heroin/crack) IPED users – people who inject drugs Vulnerable population – lifestyle including other drug use, incarceration, sexual health Changing practices and populations The illicit market 16-59 year olds reporting use of anabolic steroids 1.2 1 “Have you ever taken anabolic steroids (steroids) (not prescribed by a doctor) even if it was a long time ago? 0.8 0.6 last year Ever 0.4 0.2 0 Drug (2012/13) Last year Ever Anabolic steroids 59,000 271,000 Heroin 27,000 190,000 CSEW, 2013 Individuals attending agency-based NSP in Cheshire & Merseyside (1991 – 2011) LJMU, 2013 Percentage of NSP clients using IPEDs in the North of England Middlesbrough Kirklees Sheffield Newcastle Sunderland Bradford Halton Liverpool Sefton St Helens Warrington Wirral Manchester Bolton 67% 60% 62% 52% 60% 41% 86% 83% 43% 34% 86% 77% 60% 52% Data provided by NSP service providers/managers via [email protected] Viral and bacterial infections amongst IPED injectors Prevalence n Anti-HIV positive 1.5% (95%CI 0.56% to 3.3%) 6 Anti-HCV positive 5.5% (95%CI 3.5% to 8.3%) 20 Anti-HBc positive 8.8% (95%CI 6.3% to 12%) 26 Ever had redness at an injection site? 43% 168 Ever had an abscess/sore/open wound at injection site? 7% 27 Hope, McVeigh et al 2013 & 2014 Blood borne viruses “No bodybuilders that I know share. I mean you hear of what are called druggies, people who use other stuff. I don’t mix in those circles to be honest” Kimergård & McVeigh, 2014 Injected in previous year Proportion n Anabolic Steroids 86% 340 Growth Hormone 32% 128 HCG 16% 62 Insulin 5.6% 22 Melanotan 8.6% 34 Other PIED (inc. EPO, IGF-1 and Nubain) 5.1% 20 Hope, McVeigh et al 2013 Prevalence of growth hormone use amongst anabolic steroid users The cost of growth hormone Brand Jintropin Amount 100IU Cost £100 Cost per IU £1.00 Hydrotropin Ancemone 200IU 40IU £350 £100 £1.75 £2.50 Norditropin 30IU £140 £4.67 Genotropin 36IU £225 £6.25 Humatrope 36IU £300 £8.33 BNF £6 - £8 per IU 1997 illicit market prices Evans-Brown & McVeigh, 2009 £10-20 per IU The new stuff… Pegylated Mecano Growth Factor A long acting MGF similar to IGF-1 Growth Differentiation Factor 8 a myostatin inhibitor. FST Possibly Follistatin –myostatin inhibitor. Sermorelin Stimulates growth hormone release The illicit market “You can’t get anything pharmaceutical grade, everything is ‘underground’” (Steroid user, competing bodybuilder and gym owner aged 45) “You wouldn’t know, but you do find out the difference after you’ve finished your course and your are not getting the results you should be getting. I think that’s a risk you take, it comes in life, it comes everywhere” (Steroid user aged 27) Kimergård & McVeigh, 2014 What’s in stock? Substance labelled "Zenik" Sustanon Deca durabolin Mastebolin Parabolin Testobolin Nandrolone dec. Test. Enanthate Sustanon 250 Nandrolone Decabol 250 DecaDurabolin Omnadren Substance Found Test. & nandrolone Nothing Nothing Drostanolone Nothing Testosterone Testosterone Testosterone Testosterone Nandrolone Test. propionate Boldenone Nothing Quantity and Type 8 x 10ml Vials 2 x 1ml 2 x 1ml amps 10 x 1ml amps 5 x 1.5ml amps 1,000 amps 394 amps 10 x 1ml amps 10 x amps 1 x 2ml amps 2 x 10ml vials 1 x 2ml amps 1120 x amps Price per Ampoule/ Vial £40.00 £4.00 £9.00 £8.00 £12.00 £7.00 £8.00 £7.00 £7.00 £8.00 £32.00 £15.00 £4.00 Total price £320.00 £8.00 £18.00 £80.00 £60.00 £7,000.00 £3,152.00 £70.00 £70.00 £8.00 £64.00 £15.00 £4,480.00 Melanotan . The three most ‘popular’ internet shops identified A total of 73 vials of melanotan II 10mg were purchased Melanotan II in vials ranged between 4.32 to 8.84 mg Contained impurities ranged from 4.1 to 5.9% Kimergård, McVeigh et al, 2014 The strange case of GHRP-6… “We aim for a high standard….” Kimergård, McVeigh et al, 2014 CONTACT DETAILS Jim McVeigh Acting Director Centre for Public Health 0151 231 4512 [email protected] www.cph.org.uk Twitter @mcveigh_jim Overcoming Stigma and Barriers in NSP for PIED users Gary Beeny Setting the scene - Manchester • Year 2000 – 5% of 1750 – (80-85 clients) • Year 2014 – 58% of 1700 - (approx 980 clients) • Increase of ten fold • Job Done? Why not? • Many more AAS users out there? • Secondary supply • Buying equipment on Internet • 3 blokes in the car outside • Loads of friends in the gym Stigma? – Self perception “Its not for drugs mate, I'm a steroid user” Stigma? – Service perception “I feel like a S****head now” Barrier? – Perception of Drug Services “I went to that other Place (NSP) and it was full of druggie’s!” Barrier? – Client Confidentiality “I didn’t tell you my real details when I first came in, I didn’t know I could trust you” Solutions? • Low threshold Service • Anonymous attendance • Limited assessment • Liberal with equipment • Specialist services • Harm Reduction Philosophy The Pump Clinic Manchester • Needle Exchange with a Steroid Lead • Free Biochemistry / Hormone Testing / BBV testing • Easy to park • Multi service venue Gary Beeny The Pump Clinic Manchester 0161 274 1652 [email protected] Workshop B People who inject NPS, including men who have sex with men Monday 19 May 2014, Birmingham Harm Reduction Novel Psychoactive Substance Injecting John McNeil – Recovery Worker/NPS Lead Arundel Street Project Sheffield So What substances are we talking about? BRAND NAME, NICK NAME, CHEMICAL NAME, OR ACRONYM 2-DPMP 2CT-7 4-BD 4-MMC 6-APDB 7-UP A2 APB BATH SALTS BENZO FURY BONSAI BONSAI SUPERSLEEP BUBBLE BZP CATHINONES CHICKEN FEVER CHICKEN YELLOW CHING CHROMING COSMIC JELLY D2PM DESOXYPIPRADRO DIMETHYLTRYPTAMINE 5-APDB D DMT DONKEY DUST DOUBLE STACKED DR DEATH DRONE DUSTING ECLIPSE ECSESS ENERGY-1 ESP FAST LANE FENAZEPAM FLASH FRENZY GBH GBL GHB HAWK HERB HOLY SAGE IVORY WAVE JELLIES KILLER KIX K LEGAL E LEGAL HIGHS 2CB LEGAL X LIGHTNING FLASH LINCTUS LIQUID GOLD MCAT M1 MC MDPV MEOW MEOW MEPH MEPHEDRONE METHOXETAMINE METHYLONE MEXICAN MAGIC MINT MEXXY MEXY MIAOW MKET MXE NAPHYRONE NEMESIS NEW PSYCHOACTIVE SUBSTANCES NORRIES NPS NRG-1 NRG-2 PAPER MUSHROOMS PEBBLES PEP LOVE PEP STONED PEP TWISTED PHENAZEPAM PIPERAZINES PLANT FOOD PMA PMMA PURPLE WAVE PYROVALERONE 6-APB RAPTURE RAVE RHINO KET ROCK HARD ROFLCOPTR ROOFIES SALVIA SEVENTH HEAVEN SILVER BULLET 5-APB SPECIAL K SPICE STARS SUPER K SYNTHETIC CANNABINOIDS T-7 THRUST TNT TRIPSTACY ULTRAM VANILLA SKY VITAMIN K WHIPPETS WHITE MAGIC WHITE PEARL X XTC YABA AMT DIMETHOCAINE PMAA MPA ETHYLPHENIDATE 5-IAI 5-IT MDAI HAWAIIAN BABY WOODROSE KRATOM DESOMORPHINE NAPTHYLPYROVALERONE METHYLENEDIOXYPYROVALERONE IPHENYLMETHYLPYRROLIDINE PEP What is commonly injected? • • • • • Mephedrone (m-cat, meow, bubble, dawg, kitty) Methoxetamine (mexy, rhinoket) Phenazepam, (fez, fenazepam) Doxylam (AH-7921) Crystal Meth ( methylmethamphetamine, Ice) Combinations • Heroin + Phenazepam • Mephedrone + Heroin • Mephedrone + Phenazepam Mephedrone The first ‘legal high’ to really hit the ‘big time’ 4-Methylmethcathinone A synthetic stimulant which produces feelings of euphoria, empathy and a heightened state of alertness. The most well known of a group of NPS’s derived from cathinone Sold as a white/off white powder or capsules Caustic leads to tissue damage Possible unwanted side effects (palpitations, paranoia, fear, anxiety, sweating, sleeplessness, vasoconstriction) Effects felt immediately when injected creating an intense high Plateaus within 15-30 minutes leading to compulsive re-dosing Regular users injecting up to 20 times a day Active dose is 75mg-150mg Class B drug Our biggest concerns… • • • • • • • • • • • Dosing problems Authenticity Potency Tissue/Vein damage and other injecting injuries* Increased risk of BBV transmission Increased risk of STI’s Compulsive re-dosing New and existing cohorts Hierarchy of use leading to non reporting Very little known about most research chemicals Death Responding to NPS Injecting •NSP are the frontline response •Nothing has changed •Harm reduction is the key and should continue to underpin all interventions •Key harm reduction messages still pertinent •NSP workers need to constantly re-explore substances being used •Workers shouldn’t be afraid of terminology •Symptomatic response •NPS training useful to build confidence I will be happy to try and answer any specific questions around particular substances and the risks and harm reduction messages that apply to these during the question and answer session that follows Thank You @davidastuart @56deanstreet “ChemSex” CHAT with @Hot-Slammer Hi. You’re hot. Wot U into? Wanna cum over? 15 mins? I’ll bring Chems Do you BareBack? Do you Slam? Sexualised and Injecting Drug Use by MSM (Men who have Sex with Men) @PHE_uk @NICEcomms @LGAcomms @davidastuart 24 hour Saunas @56deanstreet Individuals/parties at homes via online “sex apps” @davidastuart BRIEF HISTORY @56deanstreet 2008 to present Reports emerging of high risk behaviours, increasing injecting use and poor injecting awareness, amongst a population that already exhibits high HIV/HCV infection rates. Of these services, Club Drug Clinic only one feeding data into NDTMS @davidastuart 56 Dean Street Response @56deanstreet Audit, Jan 2014; 144 MSM presentations at 56 Dean Street in 1 week •9/144 MSM were asked about drug use (6%) •9/9 admitted to previous club drug use (100%), and 8/9 had used in the last 3 months. •1/9 clients was offered drug related support; 0/9 received any onward referral GUM staff clearly needing guidance/support • Full time Drugs Worker employed in clinic to address ChemSex behaviours • Staff trained; awareness; what to ask; how to effect a happy referral to drug use support (usually to LGBT drug service/charity) • Compulsory question for all MSM on Proformas Trust-wide; all MSM asked routinely about fisting, injecting, barebacking, ChemSex. • Care Plans/Treatment Outcome Profiles* tailored to ChemSex’ers • Needle/Syringe provision available in clinic • Partnership work (Antidote, GMFA, Hep C Trust, Turning Point, @davidastuart @56deanstreet Simplifying access to treatment/rebranding @davidastuart @56deanstreet Data First 3 Months 300 MSM using (combinations of) Meth, Meph and GBL for sex consented to a brief intervention for drug use support. 225 of 300 were not specifically seeking drug use support on presentation •99% had never previously accessed drug use support. •65% reported 4 or more partners per “bender” (highest being 30 partners) •70% reported no memory of last sober sex encounter •34% of those on ARV therapy reported poor adherence when high (typically, every weekend), increasing infectiousness within the population •46% were HIV + •10% were currently on Hep C treatment (for 5 of these it was 2nd time infected); an additional 15% had previously been cleared/previously been treated for Hep C 45% were IVDU’s (135 individuals). Of these; •54% had never injected themselves/only ever been injected by sexual partners •45% of those reported sharing Stark contrast between what was disclosed to nurses, & what was disclosed to Drugs Advisor; particularly in regard to injecting use, and ARV adherence. @davidastuart RECOMMENDATIONS @56deanstreet •NSP street outreach and traditional methods less effective for this population; most prefer to buy online than to visit a drug service •Needle/syringe provision within all GUM services •Support/training for GUM services in identifying injecting use, communicating with IVDU’s and facilitating onward referrals •Improved dialogue between sexual Health & substance Misuse commissioning teams •Supported partnership work between drug services and their local GUM/HIV services •Improved partnership work between drug services, GUM/HIV and MSM Third sector •All MSM disclosing drug use be routinely tested for hepatitis C (regardless whether HIV+ve or whether injecting drug use is disclosed) •Drug services adapt to be more MSM-friendly; posters, separate targeted drop in’s, language on assessments/Care Plans/TOP’s, staff champion trained in equality/awareness/cultural competency @davidastuart @56deanstreet @PHE_uk [email protected] @NICEcomms @LGAcomms 147 Workshop C Young people who inject Monday 19 May 2014, Birmingham NSP – Seminar Young people Kirsty Blenkins – Programme Manager (Young People) Sam Cox – Programme Manager (Youth Justice) Introduction • Trends in drug use with young people • NICE evidence • Specialist substance misuse services – data and feedback • Developing and implementing young people friendly NSP policies • What’s different about this guidance 150 Nice NSP 19th May 2014 Background • Limited published evidence and policy documents on Needle and Syringe Programmes (NSP) for under 18’s • Systemic review of published and unpublished literature by NICE – profile of risk behaviour among YP who inject drugs • New NICE public health guidance (PH 52) on NSP published in April 2014 includes young people under 18 Nice NSP 19th May 2014 There is a continuing decline in drug use amongst young people although 1 in 6 young people reported ever having taken drugs in the past year Nice NSP 19th May 2014 NICE – Systemic review of the evidence 26 studies – Canada, USA, Ireland, Australia, Ukraine, Serbia, Moldavia, Albania and Romania • Identified key differences between younger and older people who inject drugs (PWID) • Large proportion of females – over a third in some studies (disclosing high risk behaviours • 33%+ are being injected by someone else • Sexually exploited • Experience of prison and arrest, and homelessness • High risk of sharing • Findings suggest that interventions are needed to target multiple risk Nice NSP 19th May 2014 Needle and Syringe Programmes for YP Specialist treatment services data (NDTMS): • In 2011 /2012 416 under 18’s previously injected or currently injecting - down from 663 in 2010 /2011 • 50% over 17 • 53% girls • 75% opiates, 17% other, poly drug use • Risk harm index indicates more likely to be self harming, offending, LAC, NEET, and/or pregnant • 78% access young people’s services, 19% adult services, 4% both Nice NSP 19th May 2014 Girls data Nice NSP 19th May 2014 Girls • NICE - Girls more likely to be injected by someone else and sharing equipment with sex partner • Close links with sexual exploitation • In 2012/13 34% of all young people in drug and/or alcohol treatment and 32% of new presentations were female - however 53% of injecting young people • Girls in treatment present with a different range of vulnerabilities to boys - more likely to present with selfharm issues, high alcohol and/or poly drug use and less likely to present as offending or as NEET Nice NSP 19th May 2014 Conclusions from evidence/research • Fall in injecting drug use - heroin users are getting older • Patterns of use are changing - so are injecting patterns • Image and performance enhancing drugs are not new but there has been an increase in IPED users accessing adult services • New populations to be reached – men having sex with men, young adults • Young injectors tend to have multiple risks and vulnerabilities – with particular issues for girls Nice NSP 19th May 2014 PH 52 Recommendation 5 Develop a policy for young people who inject drugs Develop and implement a local, area-wide policy on providing needle and syringe programmes and related services to meet needs of different groups of young people aged under 18 (including under 16’s) who inject drugs 158 Nice NSP 19th May 2014 Ensure policy details how local services will achieve right balance between the imperative to provide young people with sterile injecting equipment and duty to protect (safeguard) them and provide advice on harm reduction and other services. 159 Nice NSP 19th May 2014 Policy should take account of: • the young person’s capacity to consent (Gillick competence) • the risks they face • the benefits of using services • the likelihood that they would inject anyway, even if sterile needle and syringes were not provided 160 Nice NSP 19th May 2014 • Make governance responsibilities of drug services and safeguarding boards clear. The LSCB should approve local policy. • NSP should be part of a broader package of care (where possible) – especially important for under 16s 161 Nice NSP 19th May 2014 Ensure policy is responsive to the needs of young people in the local area • Provision of specialist young people’s substance misuse services, including NSP • How to encourage young people to ask for advice and help from staff providing services (as well as providing needles, syringes and injecting equipment) • How to assess service users • The skills and knowledge that staff need to deliver services - including assessment of competence to consent 162 Nice NSP 19th May 2014 Pharmacies The potential for pharmacies to provide young people with syringes and injecting equipment, if they encourage the young person to make contact with specialist services. Nice NSP 19th May 2014 Questions/themes for discussion • What experience do people have of providing NSP for YP? • What are the issues for implementation? Levers and/or barriers? • Making services more accessible for young IPED users and new NPS • Promoting development of young people friendly policies for IDUs? • Links with safeguarding? • Addressing the particular needs of young girls? • Opportunities for multi agency working? • Supporting pharmacy provision and/or provision in sexual health services? – developing appropriate protocols and pathways Nice NSP 19th May 2014 Workshop D Monitoring needle and syringe provision Monday 19 May 2014, Birmingham Assessing need for and monitoring of needle and syringe provision Martin White, Programme Manager, Alcohol, Drugs and Tobacco Division, Public Health England Assessing need • New NICE guidance PH52 recommends collation and analysis of data on injecting drug use and provision of a mix of NSP services • Assessing need across the range of people who inject drugs, e.g.: o Opiate users o Stimulant users o NPS users o IPED users • Ensuring balance in the system for these groups and between types of provision: o Pharmacy-based provision o Specialist NSP 167 Assessing need for and monitoring of needle and syringe provisions Monitoring NSP services • PH52 also recommends monitoring of services • Existing systems for monitoring: • Needle Exchange Monitoring System (NEXMS) set up in 2007 as a nonmandatory web-based national data collection tool on NSP • Wide variety of local systems (e.g. LAIKA) • PHE are working with NICE to develop a minimum set of data based on PH52 which will be recommended for collection by local areas • Initially, this is encouraged to inform local monitoring but may enable national monitoring in future 168 Assessing need for and monitoring of needle and syringe provisions Recommended data collection • The NICE guidance indicates that as a minimum data should be collected on: o Demographics and identification of those at increased risk o Drug use and injecting practices o Equipment supplied and returned o Contact with other services (e.g. specialist drug treatment, CJS) o Information and advice given o Testing of blood-borne viruses o Onward referrals • 169 PHE would encourage broader data collection (e.g. data on overdose prevention, naloxone provision) our help, your change The Health Shop Harm Reduction Service our help, your change Why do we need to collect data? Understand changes in service user population Respond effectively to these developments To identify needs and gaps our help, your change Data collection systems BOMIC Paper files/forms Service user involvement PHE and other local & national research our help, your change What do we do with this information? Talk about it! Develop targeted interventions informed by the data collected Identified gaps following data analysis and anecdotal evidence Looked at how we could work in partnership to meet the needs of this vulnerable service user group Developed Joint Working Agreement, training package and service user informed specialist NSE packs our help, your change Returns Campaigns Data shows decline in return rates Posters/flyers/amnesty/discussions demonstrate a significant increase in return rates Service users have a stake in their NSP and how it is viewed locally DVD Returns Campaign 1 If you don’t pick it up, someone else will . . . Ref: Crimestoppers Collect it, Use it, Bin it, Return it! ! Returns Campaign 2 Limitations and Forward Planning Qualitative Information Can the system keep up? NSP Pharmacies Lost data Local/National data our help, your change Thank you for listening! Maria Storry Harm Reduction Worker The Health Shop Substance Misuse Services – Specialist Services Directorate Nottinghamshire Healthcare NHS Trust Email: [email protected] Tel: 0115 947 5414 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham Evidence into practice and policy: needle and syringe programmes - protecting people and communities Parallel sessions feedback Professor Mike Kelly, Head of Public Health, National Institute for Health and Care Excellence Monday 19 May 2014, Birmingham People who inject IPEDs • • IPED injecting growing but highly localised Patterns of use different to people who inject psychoactive drugs: intramuscular/subcutaneous, drugs in vials ready for injection, range of substances used in cycles • • • • • • • • • 182 Health and fitness, ‘not’ drug use’ Extensive secondary distribution, and injection by others is common Non-injecting psychoactive drug use is common Sexual and injecting risks IPED injectors may need routes of access to NSP other than ‘traditional’ services: pharmacies may be useful but also, eg gym outreach Tailor equipment offered to the needs of people injecting IPEDs Give targeted advice on drugs, eg may be counterfeit and contaminated Offer other services to engage users, eg metabolic testing and outreach Address health needs, e.g. hepatitis B vaccination & sexual health Needle and syringe programmes - protecting people and communities, 19 May 2014 People who inject NPS / MSM 183 • Different populations: NPS-only and NPS with, on top of or instead of, ‘traditional’ injection drugs • Additional risks from frequent injecting with sometimes ‘corrosive’ or unknown substances • As always, focus on the person, not the drug • Young people who inject NPS, and MSM, may be more likely to use health services such as sexual health and these may be a suitable outlet for NSP • Sexual disinhibition • All NSP should offer access to BBV testing • NSP staff need to be culturally competent to work with MSM and other NPS users Needle and syringe programmes - protecting people and communities, 19 May 2014 Young people 184 • Injecting among young people is rare • For many, it is part of a wider pattern of multiple risk and vulnerability, requiring full assessment and safeguarding • Young people should be provided with sterile injecting equipment as part of a broader package of care to meet their other needs, where possible • For some YP, especially those using IPEDs, there may not be the same multiple concerns. However, there is growing concern about use of IPEDs by young people and what opportunities there are to intervene • All areas should have a policy to ensure that age appropriate provision is in place for those who need it • If pharmacies are to provide NSP to young people, they will need support to develop pathways and links to YP treatment services Needle and syringe programmes - protecting people and communities, 19 May 2014 Monitoring 185 • Local data is essential to inform an assessment of need among every injecting population, which in turn informs commissioning • Standardising this data will make benchmark comparisons between services and areas easier, and will facilitate uploading to any future national data system • Use to ensure accessible provision for all people who inject drugs, including appropriate mix of NSP provision Needle and syringe programmes - protecting people and communities, 19 May 2014 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Closing Professor Mike Kelly, Head of Public Health, National Institute for Health and Care Excellence Monday 19 May 2014, Birmingham Summary • A continuing process of delivery • 2009 and now 2014 guidance • NICE and PHE continue to support implementation, particularly from PHE Centre teams at a local level. • New and growing populations for NSP and IPEDs but job remains the same: • Provide range of accessible provision according to local need • Increase coverage • Provide relevant and accurate advice and pathways to relevant services Pledge cards and evaluations Thank you and goodbye 187 Needle and syringe programmes - protecting people and communities, 19 May 2014 Evidence into practice and policy: needle and syringe programmes - protecting people and communities Monday 19 May 2014, Birmingham