dermatology - The University of Chicago Department of Medicine

T H E
U N I V E R S I T Y
O F
C H I C AGO
D E R M AT O L O G Y
2 0 1 2 - 2 0 1 3 V o l u m e 7 A T
T H E
Inside
• The First Section Chief
• IWA Program
• Philanthropy in Focus
• 2012 Publications
• News From the Clinic
• 2012 Alumni Updates
• Allan Lorincz
Memorial Lecture
F O R E F R O N T
O F
S K I N
H E A L T H
A N N U A L
A N D
R E P O R T
R E S E A R C H
CELEBRATION
Dr. Samuel Becker’s Memorabilia
on Display
S
amuel W. Becker, MD—As the first
Section Chief (1928-1942), Dr. Becker
was instrumental in laying the foundation for
the study of cutaneous science and practice at
the University of Chicago. Now The Section
has the privilege of receiving several precious
memorabilia through the generosity of his
daughter, Dr. Bess Brennan (retired) and
granddaughter, Dr. Terry Brennan—currently
a practicing dermatologist in Highland,
Indiana. All items will be on display in the
Section’s academic offices. A few items are
illustrated on page three of this report.
The family shares some facts and anecdotes
about their patriarch:
• Faculty Member
Samuel William Becker was born July
11, 1894 in Benton Harbor, Michigan. After
graduating from Benton Harbor High School
in 1910, he discovered an interest in electrical
engineering and built a radio using wet-cell
batteries. He used this device to contact ships
on Lake Michigan and even as far as the coast
of South America. His father, Myron Becker,
however, wanted him to study medicine as
his older brother George was doing. After
working to earn money, he started as an
undergraduate at the University of Michigan
in 1912. One of his jobs was as telegrapher
on a Lake Michigan ship—he even kept his
telegraph key.
... Continued on page 3
Goes Global
Dermatology
Section Photo:
Dr. Becker (circled)
pictured with
Dr. Maximilian Obermeyer,
Dr. Stephen Rothman,
and other Section
faculty and staff
members.
... Continued on page 2
A Letter from the Section Chief
W
elcome to the seventh
Annual Report of The
University of Chicago Section of
Dermatology. We have decided
to correspond the publication of
this and future editions based on
the academic year, rather than the
calendar year. This will allow us
to provide you with more timely
information on the happenings
and events of our busy Section.
There are at least three overarching
themes of this current edition:
the acquisition of historically
significant memorabilia from our
first Section Chief, Dr. Samuel
W. Becker; a focus on community
outreach activities, and faculty and
staff news. We also present in this
report a wonderful “Philanthropy in
Focus” piece on the Aronson family.
When Dr. Becker’s daughter
and granddaughter contacted the
Section’s academic offices and
expressed interest in sharing with
us some found historical objects
from Dr. Becker’s practicing days,
we gratefully met them and we
were thrilled at the extent of the
discoveries. Dr. Bess Brennan
and Dr. Terry Brennan were very
gracious. Please read the lead article
to enjoy anecdotes and page three
to see a visual sampling of the
treasures. All are welcome when on
campus to visit the Section offices
and see the display case.
The Section led the way in
community events this past academic
year. We began 2012 with hosting
a joint educational event with the
International Women’s Association
called “Many Colors: One Skin. This
was followed by four skin cancer
screenings throughout the year,
staffed by faculty and housestaff.
These screening activities registered
the support of either the Chicago
Dermatology Society or the Skin
Cancer Foundation. Due to the great
response, we plan to continue this
outreach into the future. Faculty
member, Dr. Aisha Sethi, who
enjoys an increased presence in the
Department of Medicine’s Global
Health Initiative Program, organized
a Global Health Day on campus with
the Ambassador-at-Large for Global
Women’s Issues, Melanne Verveer,
as the keynote speaker.
Lastly, there were a few
personnel changes to mention,
both faculty and staff. We are
happy to announce that Dr.
Sarah Stein accepted the role of
Residency Program Director. She
is bringing a lot of fresh ideas and
structure to the program, working
in conjunction with the Associate
Residency Director, Dr. Arlene Ruiz
de Luzuriaga. Dr. Stein is also the
“Faculty in Focus” entry in this
edition. The Section said goodbye
to Dr. Bernhard Ortel, who accepted
the prestigious job of Chairman
of Dermatology at NorthShore
University Health Center in the
northern suburbs. We also welcomed
a new Section Administrator, Nishq
Mody, whose background story is
on page twelve. Please enjoy and
keep in touch.
With all best wishes,
Christopher R. Shea, MD
Section Chief, Dermatology
In Memoriam:
Dr. Darryl M. Bronson MD, MPH (1950-2012)
D
r. Bronson, a distinguished alumnus of our
dermatopathology fellowship program, has died.
The following obituary was posted on ObitsforLife.com:
Dr. Bronson’s memory will be cherished by wife, PaiPai Cheng, son Ariel Bronson (fiancé Omri Gottesman
MD) and step-daughter Eleanor Sabaduquia, as well
as many other family members. Darryl was highly
regarded locally, nationally and internationally as a
both a dermatologist and dermatopathologist. In March
of 2012 he became the Vice President-Elect of the
American Academy of Dermatology. He has been an
attending physician at North Shore University Hospitals
in Dermatology and Pathology and at Northwestern Lake
Forest Hospital in Dermatology/Dermatopathology. Dr.
Bronson was Past Chairman and Residency Program
Director, Division of Dermatology of Cook County
Hospital. Some of Dr. Bronson’s past professional
activities included: President, Chicago Dermatological
Society; President, Illinois Dermatological Society;
President, Noah Worcester Dermatological Society;
Board of Directors, American Academy of Dermatology;
Board Member, Sulzberger Institute for Medical
Education; Executive Committee, Advisory Board,
American Academy of Dermatology; Executive Medical
Staff, Cook County Hospital; Director, Laboratory
of Dermatopathology, Rush Medical Center; Chair,
Dermatopathology Task Force, American Academy
2
of Dermatology; Chair, Teaching Slide Task Force,
American Academy of Dermatology; Chair, Audit
Committee, American Society of Dermatopathology;
Computer Technology Committee, American Academy
of Dermatology; Managed Care Task Force, American
Academy of Dermatology; Membership Committee,
American Academy of Dermatology; State Vice-Chair,
Leader’s Society, Dermatology Foundation; Health
Care Finance Committee, American Academy of
Dermatology; Dermatopathology Task Force, American
Academy of Dermatology; Instructor in Dermatology,
University of Illinois College of Medicine; International
Society of Dermatopathology; Women’s Dermatologic
Society and had 29 Peer Reviewed Articles and 3 Book
Chapters. Dr. Bronson’s training included an internship
in Internal Medicine, Cook County Hospital, Residency
in Dermatology, Cook County Hospital and Fellowship
in Dermatopathology, University of Chicago and New
York University. Dr. Bronson earned his Medical degree
from the University of Illinois where he was also a James
Scholar in Independent Study and received his Master’s
Degree in Public Health at the same time he was attending
medical school. Dr. Bronson was chosen at Top Doctors:
Chicago Metro Area 2000-2005 and Top Doctors in
America. Dr. Bronson was not only a fine physician, but
also a prize-winning golfer and avid foodie.
IN MEMORIAM
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
In 1920, Dr. Becker graduated from the
University of Michigan with MA and MD
degrees. The same year, he married medical
student Bess Parham.
His internship was at
Philadelphia General
Hospital from 19211923. He then became
a Fellow of the Mayo
Foundation from 19231926 under Dr. John
H. Stokes. In 1926,
he was named a Fellow
of the National Research
Council and assigned to
the Dermatology Clinic in
Zurich for one year under
Prof. Bruno Bloch. His
work began here in melanin
and the dopa reaction, and so did his lifelong
interest in pigmentary disturbances. In
1927, the Becker family moved to Chicago,
where he became a faculty member at The
University of Chicago.
In early twentieth
century America,
syphilis was a great
scourge—one in ten
adults had it. Before
the availability of
antibiotics, treatments
were almost as bad as
the disease. Dr. Becker
authored a book (Ten
Million Americans Have
It! J. B. Lippincott Co;
1937) to educate the lay
public about the disease.
In 1945, he left the University
to open a private practice in
Chicago, sharing an office with Dr.
Evangeline Stenhouse, one of his
former students. In 1955, he accepted
the position of Chief of Service in
Dermatology at Long Beach Veterans
Administration Hospital. In 1964
he retired and became a Professor
Emeritus at the University of Southern
California. He passed away August 15, 1964
in Hollywood, California.
Daughter Bess recalls that
Dr. Becker was proficient
in Latin and German and
used the latter to review
medical articles. He believed
that thorough literature
review was essential to
both research and patient
care. His knowledge of
Latin was also helpful to
his daughter, who regularly
left her Latin homework on
the table for him to read and
correct before he left for
the University of Chicago
early in the morning. If the
children mispronounced an English word, Dr.
Becker would always gently correct them. Dr.
Becker’s love of language honed his excellent
writing skills, whether his audience was the
public or the medical community.
3
International Women Associates
Program and Discussion
faculty in focus
D
r. Sarah Stein is an Associate
Professor of Medicine
and Pediatrics at the University of
Chicago Pritzker School of Medicine,
where she has been practicing
pediatric dermatology for 13 years.
She received her medical degree from
Albert Einstein College of Medicine
in New York City, then went on to
complete her pediatrics training at
The Floating Hospital for Children
at New England Medical Center in
Boston, followed by dermatology
and pediatric dermatology training
at Northwestern University Feinberg
School of Medicine. Dr. Stein is
triple board certified, in dermatology,
pediatric dermatology, and pediatrics.
She has a special interest in the
diagnosis and management of
dermatologic disorders in pediatric
patients with skin of color. She
is an expert in the diagnosis and
management of childhood skin
diseases, including dermatitis of
various types, pigmentary disorders,
birthmarks, disorders of hair and
nails, infectious skin conditions, and
cutaneous manifestations of internal
diseases. Dr. Stein’s philosophy is
that family education and support
are fundamental in pediatric patient
care and she works tirelessly to
accomplish these goals.
Dr. Stein is a clinician-educator
whose work includes dermatology
curriculum development and
teaching at the faculty, resident,
and medical student levels. As of
July 2012, she has taken on the
role of Dermatology Residency
Program Director. In this position,
Dr. Stein hopes to maintain the
excellent traditions of the University
of Chicago training program,
attracting top-ranked medical
4
PROFILE
students, providing the trainees
with a stimulating, challenging and
fulfilling educational experience, and
producing dermatologists who will
pursue fellowship training, scientific
research and provide superior patient
care in private and academic settings.
In previous years she coordinated the
general and pediatric dermatology
electives for the medical students. She
teaches dermatology residents on a
daily basis both in the clinic and in
teaching conferences. Involvement
in the education of the pediatrics and
medicine/pediatrics residents is very
dear to Dr. Stein and she participates
in the Department of Pediatrics
morning report conference almost
weekly, as well as running core
curriculum teaching sessions for these
residents. In 2006, she received the
Department of Medicine’s Excellence
in Education and Clinical Care Award.
Writing for peer-reviewed
journals and textbooks and
participating in the creation of
web-based reference sources, as
well as teaching at CME events for
dermatologists and primary care
physicians, are additional rewarding
opportunities. Dr. Stein served as
the Vice President of the Chicago
Dermatological Society from
2011-12 and is active in the Society
for Pediatric Dermatology. She
serves as a reviewer for Pediatric
Dermatology, Journal of the
American Academy of Dermatology,
and Archives of Dermatology. In
her leisure time, Sarah relishes
spending time with her husband
Adam, and children Ben (10yo) and
Amelia (7yo), and Travel, exercise,
cooking, baking, literature, movies,
and gardening keep everyone in the
family busy.
T
he Section had the honor of
creating a joint educational
event with the International Women’s
Association on Saturday, January
21st, 2012. The event was called
“Many Colors, One Skin.” The
Drake Hotel served as the venue for
the program and lunch discussion.
Presentations included:
• Dr. Christopher R. Shea
“Human Skin Color: An
Evolutionary Perspective”
• Dr. Aisha Sethi
“Albinisim in Malawi, Africa:
A Tragic Collision of Biology
and Sociology”
• Dr. Arlene Ruiz de Luzuriaga
“Arsenic in Bangladesh:
An Environmental and Public
Health Crisis”
• Dr. Vesna Petronic-Rosic
“Update on Sun Protection
and Vitamin D”
International Women Associates is
a Chicago-area forum that connects
women with diverse international
backgrounds. IWA’s vision is to
create a more just and peaceful
world through mutual respect and
understanding. IWA works with
organizations and individuals whose
goals are harmonious with its
mission and advocates for universal
human rights, especially for women
and girls. Special thanks to Ms.
Gay-Young Cho, the IWA board and
membership for their efforts.
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Philanthropy in Focus
From left to right: James Lopez, PhD (U of C PhD 2010- Erica’s husband),
Erica Aronson MD (Laboratory School lifer, MD- U of C Pritzker School of
Medicine, internship U of C, Residency U of C), Iris K Aronson MD (residency
U of C, dermatopathology fellowship U of C) , Andrew J Aronson MD,
MBA,MPH (MD U of Chicago, pediatric internship, residency, nephrology
fellowship and then faculty at U of Chicago total > 30 years), Elena Aronson
BA, MA (Laboratory School lifer) .
Not pictured: Gregory Newmark PhD, Elena’s husband who will begin
teaching a course at U of C this Spring in Transportation.. and Elena’s
children, Nathaniel, 2 years old and Allegra 2 months old, possible future U
of C alums as well.
Iris K. Aronson MD and Andrew
James Aronson MD MBA MPH;
Erica R. Aronson MD
board certification in Dermatologic Laboratory and
Diagnostic Immunology.
Andrew joined the University of Chicago faculty
as Head of Pediatric Nephrology in the Department
of Pediatrics in 1975 and served in that position
for twenty-four years. He is now Clinical Professor
of Pediatrics and Pediatric Nephrology at the
University of Illinois in Chicago as well as serving as
consultant in Pediatric Nephrology at Hope Children’s
Hospital, Illinois Masonic Medical Center, and Little
Company of Mary Hospital.
Iris has spent thirty-four years in the Department of
Dermatology at the University of Illinois at Chicago,
where her interest in complex dermatologic diseases
grew. She has been Director of the Immunopathology
Laboratory for twenty-five years, Associate Program
Director of the residency for eight years, acting head
of the Department, for one and one-half years and
then Associate Head of the Department for seven
years. Her love and interest in dermatology as well
as her passion for patient care, teaching students and
residents, and interest in the underlying mechanism
of disease have never waned. She credits her training
at the University of Chicago and exposure to her
extraordinary mentors in the Section of Dermatology
as the reason for her lifelong love of dermatology
and learning. These mentors were kind, nurturing
and supportive, and they were able to draw out the
best in each of the residents whom they taught. Iris
has always felt that this type of atmosphere was vital
to her growth and development as a physician and
dermatologist.
and Erica were “lifers” at the University of Chicago
Laboratory Schools and have both gone on to pursue
their education in colleges and graduate school. Iris
and Andrew could not be prouder or happier parents.
Iris was born in Tel Aviv to holocaust survivors,
Elena married Gregory L. Newmark, PhD, whom
and as a child immigrated to the USA with her
she met at graduate school in Berkeley, and they
family and settled in the north side of Chicago. She
have two beautiful children, Nathaniel and Allegra.
graduated from the University of Illinois at Chicago
Erica and James Lopez met at Stanford University
with a major in chemistry (as the first college
and came back to enter the University of Chicago,
graduate in her family) and entered the University
Erica to pursue a career in medicine, entering the
Of Illinois College Of Medicine. While in college
Pritzker School of Medicine and then discovering that
she met her husband, Andrew, who later attended
Dermatology was her calling, and James to pursue his
The University of Chicago School of Medicine.
PhD in biomedical science. The Aronson-NewmarkDuring medical school they married and settled
Lopez family is one heavily U of C connected clan.
in Hyde Park, where they continue to live. While
Erica was clearly influenced by her mother’s love
doing an internship at Michael Reese Hospital,
of dermatology. Although she initially planned a
Iris did a rotation in dermatology with Dr. David
career in psychology, and then research in other fields
Fretzin and enjoyed it so much that she decided
of medicine, the passion Iris felt for dermatology led
to become a dermatologist. Andrew was doing his
Erica to explore her own interest in the field. Erica
pediatric internship and residency, and later pediatric
has benefited from Iris’s love of clinical teaching and
nephrology fellowship, at the University of Chicago.
admires her multitude of talents including her ability
After Iris’s internship, Iris and Andrew took a year
to connect with her patients. She often looks to her
off from medicine and traveled throughout Europe
mother for advice on how to be the best clinician she
and Morocco. When they returned, Iris was fortunate
can be in this varied and intellectually stimulating
to be accepted to the Dermatology residency at
area of medicine. Erica not only followed in her
University of Chicago. Dr. Allan Lorincz was the
mother’s footsteps in dermatology, she took the same
Section Chief then and for many years thereafter. Iris
road to the Section of Dermatology at the University
will be eternally grateful that he chose her to be one
of Chicago for her residency as Iris often extolled on
of his residents, and she told him later how much
the exemplary teaching she had received there.
the training in dermatology meant to her. Iris loved
Iris is very interested in the Section of
the residency at The University of Chicago, where
Dermatology’s continuing success and excellence in
there were several special teachers in addition to Dr.
patient care, student and resident education , research
Lorincz. Dr. Keyoumars
and scholarly academic
Soltani was Iris’s mentor
efforts which contribute
These teachers and role models taught her not only to ask “What is
and helped her with
to the training of future
a number of research
it?” but also “Why is it so?” Her interest in underlying pathophysiological dermatologists. As she
projects. Dr. Sylvia Griem
recalls from her training,
mechanism of disease, be they immunologic, biochemical or genetic was
was an excellent clinician
and as she and Andrew
and teacher, and Dr. Maria inspired during her training time at the University of Chicago.
appreciate in watching
Medenica was a role
Erica becoming an excellent
model in pursuing a Dermatopathology fellowship.
Ten years after Iris and Andrew were married, they
and talented dermatologist, the Section continues to
Iris’s interest in Immunopathology, sparked
had their first daughter, Elena. Three years later they
provide an environment for learning and a model that
by work with Dr. Soltani led to her subsequent
welcomed their second daughter, Erica. Both Elena
prepares physicians for their future careers.
“
”
5
2012 Publications
Anand S, Ortel BJ, Pereira SP, Hasan T, Maytin EV.
Biomodulatory approaches to photodynamic therapy for solid
tumors. Cancer Lett 2012; 326: 8-16.
Kaminska EC, Ortel B, Sharma V, Stein SL. Narrowband UVB
phototherapy as a novel treatment for Netherton syndrome.
Photodermatol Photoimmunol Photomed 2012; 28:162-4.
Bangash H, Patel S, Soltani K, Shea CR, Sethi A. Blistering
eruption on the chest of a 30-year-old pregnant woman. Int J
Dermatol 2012; 51:1429-31.
Kaminska EC, Larson R, Petronic-Rosic V. Amelanocytic
anhidrotic alopecia areata-like phenotype after allogeneic
hematopoietic cell transplant. Arch Dermatol 2012;148: 931-4.
Basko-Plluska J, Petronic-Rosic V. Psoriasis: epidemiology
and natural history and differential diagnosis. Psoriasis:
Targets and Therapy 2012; 2: 67–76.
Kaminska EC, Yu Z, Kress J, Petronic-Rosic V, Soltani K.
Erythematous eruption with marked conjunctival injectionquiz case. Arch Dermatol 2012; 148: 1199-d.
Beveridge MG, Polcari IC, Burns JL, Adler A, Hendrickson
B, Stein SL. Local vaccine site reactions and contact allergy to
aluminum. Pediatr Dermatol 2012; 29: 68-72.
Kubic JD, Mascarenhas JB, Iizuka T, Wolfgeher D, Lang D.
Glycogen Synthase Kinase-beta promotes cell survival, growth,
and PAX3 stability in melanoma cells. Mol Cancer Res 2012;
10:1065-76.
Duffy K, Mann D, Petronic-Rosic V, Shea CR. Clinical
decision making based on histopathological grading and
margin status of dysplastic nevi. Arch Dermatol 2012;
148: 259-60
Fox MD, Billings SD, Gleason BC, Moore J, Thomas AB,
Shea CR, Victor TA, Cibull TL. Expression of MiTF may
be helpful in differentiating cellular neurothekeoma from
plexiform fibrohistiocytic tumor (histiocytoid predominant) in
a partial biopsy specimen. Am J Dermatopathol. 2012;
34: 157-60.
Han WN, He YY. Caffeine and apoptosis. In: Preedy VR, ed.
“Caffeine: Chemistry, Analysis, Function and Effects.” London:
The Royal Society of Chemistry, 2012; 21; 382-9.
He YY. SIRT1. In: Schwab M, eds. “Encyclopedia of Cancer.”
Philadelphia: Springer Healthcare, 2012.
Han WN, Ming M, Zhao R, Pi JB, Wu CL, He YY. Nrf1
CNC-bZIP protein promotes cell survival and nucleotide
excision repair through maintaining glutathione homeostasis.
J Biol Chem 2012; 287: 18788-95.
Han WN, Soltani K, Ming M, He YY. Deregulation of XPC
and CypA by cyclosporin A: an immunosuppressionindependent mechanism of skin carcinogenesis. Cancer Prev
Res 2012; 5: 1155-62.
Hemmge V, Tanowirz H, Sethi A. Trypanosoma
cruzi infection: A review with emphasis on cutaneous
manifestations. Int J Dermatol 2012; 51: 501-8.
Ladizinski B, Cruz-Inigo AE, Sethi A. The genocide of
individuals with albinism in Africa. Arch Dermatol 2012;
148:1151.
Maytin EV, Honari G, Khachemoune A, Taylor CR, Ortel B,
Pogue BW, Sznycer-Taub, N, Hasan T. Vitamin D combined
with aminolevulinate (ALA)-mediated photodynamic therapy
(PDT) for human psoriasis: a proof-of-principle study.
Isr J Chem 2012; 52: 767-75.
Ming M, He YY. PTEN in DNA damage repair. Cancer Lett
2012; 319:125-9.
Nwaneshiudu A, Kuschal C, Sakamoto FH, Anderson RR,
Schwarzenberger K, Young RC. Introduction to confocal
microscopy. J Invest Dermatol 2012; 132: e3.
Petronic-Rosic V. Eighth World Congress of the International
Academy of Cosmetic Dermatology, Cancun, Mexico, January
31 to February 4, 2012. Clin Dermatol 2012 30:672-9.
Petronic-Rosic V. Melanoma. In: Bope ET, Kellerman RD, eds.
“Conn’s Current Therapy 2012.” Philadelphia: Elsevier 2012;
234-6.
Rallis E, Petronic-Rosic V, Korfitis C. Erlotinib-induced scalp
perifolliculitis. Skinmed 2012;10: 70-1.
Sansaricq F, Petronic-Rosic V. Dermatitis Herpetiformis:
What practitioners need to know. Pract Gastroenterol 2012;
36; 39-44.
6
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Sansaricq F, Stein SL, Petronic-Rosic V. Autoimmune Bullous
Diseases in Childhood. Clin Dermatol 2012; 30:114-27.
Sethi A. Bacterial skin and soft tissue infections in the tropics.
In: Magill AJ, Ryan ET, Solomon T, Hill DR, eds. “Hunter’s
Tropical Medicine and Emerging Infectious Diseases Ninth
Edition.” Philadelphia: Elsevier 2012; 515-8.
Sethi A. Tuberculosis and infections with atypical
mycobacteria. In: Goldsmith L, Katz S, Gilchrest B, Paller
A, Leffell KW, eds. “Fitzpatrick’s Dermatology in General
Medicine Eighth Edition.” New York: McGraw-Hill 2012;
2225-40.
Wu CL, Qiang L, Han WN, Ming M, Viollet B, He YY. Role
of AMPK in UVB-induced DNA damage repair and growth
control. Oncogene Online 2012; e 1-8.
Zhang X, Hyjek E, Soltani K, Petronic-Rosic V, Shea CR.
Immunohistochemistry for immunoglobulin g4 on paraffin
sections for the diagnosis of pemphigus. Arch Pathol Lab.
Med 2012; 136: 1402-7.
Zhao BZ, Ming M, He YY. Suppression of PTEN transcription
by UVA. J Biochem Mol Toxicol Online 2012; 27; e 1-8.
PUBLICATION IN FOCUS
Kubic JD, Mascarenhas JB, Iizuka T, Wolfgeher D, Lang D. Glycogen Synthase Kinase-beta promotes cell survival, growth,
and PAX3 stability in melanoma cells. Mol Cancer Res 2012; 10:1065-1076. “AACR Highlighted Article.”
T
he Glycogen Synthase Kinase-3 (GSK-3) proteins regulate
PAX3, a developmental protein known to support cellular growth and
several very important cellular processes, such as metabolism,
migration in melanocytes. “We are very excited about this finding,
proliferation, and transcriptional regulation. These proteins are active
due to the very significant effect on melanoma cells, as well as the
during development and cellular remodeling, and are dysregulated
use of small molecule compounds that have already been proven safe
in pathological states including diabetes, Alzheimers Disease, and
in clinical trials for neurodegenerative diseases,” stated lead author
Parkinsons Disease. In cancer, these proteins may function as tumor
Jennifer Kubic, PhD. This study may provide a foundation for new
promoters or repressors, depending on the cell type. A role for GSK-3
therapeutic strategies for melanoma with GSK-3 as a target.
in melanoma has been mostly overlooked and thought to be inactive due
to the phosphorylation state of these proteins. However, a University
of Chicago research team led by Deborah Lang, Assistant Professor of
Medicine in the Section of Dermatology, discovered that these kinases
are active in melanoma and behave as oncogenes. A blocking of the
activity of these kinases, by the use of either gene targeting or the
use of small molecule drug inhibitors, led to a significant inhibition
of tumor cell growth and survival, as well as signs of melanocytelike differentiation. One mechanism through which GSK-3 promotes
melanoma cells is by the direct phosphorylation and maintenance of
7
Faculty Awards and Honors
Yu-Ying He, PhD
• Awarded American Cancer Society
$720K Research Scholar Grant
for “Molecular Mechanisms of
Skin Carcinogenesis in Organ
Transplant Recipients”
Vesna Petronic-Rosic, MD
• Named Chairperson of the
Inaugural Edward L Keyes
Scholarship Resident Contest,
VIII World Congress of the
International Academy of Cosmetic
Dermatology, Cancun, Mexico,
January 31-February 4, 2012
• Honored by the Faculty of 1000
(F1000) evaluation committee
for the article Vitiligo: A
Comprehensive Overview Part II:
Treatment Options and Approach to
Treatment (JAAD 2011)
Aisha Sethi, MD
• Awarded “Members Making a
Difference Award” by the American
Academy of Dermatology (AAD)
• Named an American Medical
Association (AMA) Mentor by the
AMA Women’s Physician Council
Christopher R. Shea, MD
• Awarded “Top Doctor”
(Dermatology), Chicago Magazine
• Awarded “Chicago Superdoctors”
(Dermatology)
• Named one of “U.S. News Top
Doctors” (top 1% nationally
in Dermatology)
Keyoumars Soltani, MD
• Elected to the Council of the
University Senate for a threeyear term
Sarah Stein, MD
• Promoted to Dermatology
Residency Program Director
Housestaff
Honors
Adaobi Nwanshiudu,
MD, PhD was invited to write for
the British Medical Journal Point of
Care Monograph entitled Squamous
cell carcinoma of the skin. This is
a contributing piece with Dr.
Keyoumars Soltani.
Edidiong Kaminska, MD
won The International Academy of
Cosmetic Dermatology’s inaugural
Edward L. Keyes Award for the best
Resident Papers during the Eighth
World Congress in Cancun. This
honor was named after the first
cosmetic dermatologist who developed
the cutaneous punch, or the Keyes
punch. Her co-winner was Razvigor
Darlenski, MD, PhD from Sofia,
Bulgaria. They presented their case
reports on combining field therapies
with sequential topical 5-fluorouracil,
followed by 5-aminolevulininc acid
photodynamic therapy for actinic
keratoses and hair extensions as a
novel source of a well-known contact
allergen. Dr. Vesna Petronic-Rosic
served as the named Chairperson of
this contest.
News From the Clinic
The Mohs Team
Mole Mapping
L to R: Diana Bolotin, MD, PhD,
Kathy Fiscelli, HTL (ASCP), Ginny
Cooper, LPN, Jennifer Tang, RN,
and Vivek Iyengar, MD.
Jennifer Tang, RN - Jennifer
received her Bachelor of Science
in Nursing from the University of
Illinois at Chicago in 2002. Her
experience as a Registered Nurse
(RN) has ranged from work in
a surgical intensive care unit at
Rush University Medical Center to
outpatient nursing in plastic surgery
and Mohs surgery at Northwestern
Medical Faculty Foundation. At the
University of Chicago Medicine,
Section of Dermatology, she works
very closely with patients to ensure
pre- and post-operative continuity of
care and a positive patient experience
as the lead Mohs Surgery Nurse
Coordinator.
Ginny Cooper, LPN - Ginny
completed a Bachelor of Science
degree from Indiana University and
8
subsequently received her licensed
practical nurse (LPN) certificate from
Ivy Tech Community College. She
joined the University of Chicago
Medicine, Section of Dermatology in
2011 and has been an integral part of
procedural dermatology.
Kathleen Fiscelli, HTL (ASCP) Kathy has been a board-certified
histotechnologist since 1992. She
has worked in numerous hospitals as
both a technician and lab supervisor.
Kathy has opened three Mohs labs
herself, which included training of
staff specifically in Mohs procedures.
She currently does Mohs histology
exclusively at the University of
Chicago Medicine, Section of
Dermatology, while also performing
duties as a full-time lab supervisor at
Stroger Hospital.
T
he Section is pleased to announce the addition of the Mole Mapping
Clinic to further serve the needs of our patients. A vision realized by
Dr. Shea in 2012, our Mole Mapping clinic with the FotoFinder System® is
the most advanced method for early diagnosis of melanoma, a potentially
deadly skin cancer. It employs a non-invasive, digital photographic technique
whereby patients at risk of developing melanoma can have their total body
skin surface photographed, and any unusual moles precisely documented
using a surface microscope. These images are then analyzed and stored, and
any changes over time are demonstrated by comparing the initial images with
additional digital photographs taken in the future. Long-term observation
through mole mapping provides the best opportunity to detect new moles,
moles at risk for developing into melanoma, and help to avoid unnecessary
excisions of benign moles. In our newly designed Photo Studio, Dr. Shea can
create a map of a patient’s entire skin surface.
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Alumni Updates
Amy Derick, MD (’06):
Dr. Derick broke ground on a
second Derick Dermatology
practice location in Crystal Lake,
Illinois this summer. The Derick
family also welcomed the newest
family member, Jane Adelaide
Shoshana Derick, on April 5th,
2012.
Keith Duffy, MD
(Fellow ’09): Dr. Duffy
published in Archives of
Dermatology, JAAD, and
Annals of Surgical Oncology.
He is an Assistant Professor at
the University of Utah and is
practicing Mohs surgery and
dermatopathology. There will be
another addition to his family in
March 2013.
Ana Eng, MD (’72):
Dr. Eng published a book
entitled “We Are Not Here
Forever” Bloomington: Xlibris
2012. Dr. Eng divulged that
the book is so named after she
had two emergent experiences
related to the presence of sodium
bisulfite in foods.
Tunisia Finch, MD (’12):
Dr. Finch joined the staff of
Family Dermatology in Atlanta.
Shani Francis, MD (’12):
Dr. Francis has opened a new
hair clinic through NorthShore
University Health System in the
northern suburbs of Chicago.
She has also published in
Archives of Dermatology.
John Fox, MD (’11):
Dr. Fox published an article on
Endheim-Chester Disease in
Archives of Neurology.
Ingrid Polcari, MD (’11):
Dr. Polcari began working at
the University of Minnesota
Amplatz Children’s Hospital
as a pediatric dermatologist.
The Polcari brood (including
husband Tony and big sis Clara)
also expanded with the addition
of twins Elle and Juliet born on
September 23rd, 2012.
Brian Pucevich, MD
(’12): Dr. Pucevich and his
wife, Juliann, welcomed their
daughter Elena Ann on February
17th, 2012.
New Additions
Evelyn Y. Bo
Jane Derick
Nathan Jacob Grimshaw
Sophie Amelia Plluska
Elena Ann Pucevich
Asher Xiuyuan Qiang
Eric Ruiz
William Nolan Sheehan
Jessica Sheehan, MD
(’09 and Fellow ’10):
Dr. Sheehan and husband Jake
welcomed son William Nolan
Sheehan on May 31st, 2012.
Michael Jude Welsch,
MD, FAAD (’05):
Dr. Welsch’s clinic, SkinMD
in Orland Park, Illinois,
earned a College of American
Pathologists (CAP) accreditation
for his dermatopathology
laboratory.
Class of 2012 Passing
the Boards:
9
PGY-2 Dermatology
Residents:
Sogyong Auh, MD, PhD
completed her undergraduate degree
in Biology and her MD and PhD. in
Pathology at the University of Chicago.
Sogyong volunteered as Itinerary
Coordinator for a medical mission trip to
Cuba and served as president of Habitat for
Humanity’s efforts in North Carolina and
Nicaragua. She enjoys photography and knitting.
Min Deng, MS, MD
received her undergraduate degree in
Biology at the Massachusetts Institute of
Technology, and completed her MS/MD
at Case Western Reserve University. She
received a National Institutes of Health
Clinical Research Training Program
Fellowship Award in 2009 to investigate
microRNA in primary T-cells. Min is first violinist at the National
Institutes of Health Philharmonia orchestra, and speaks Mandarin
Chinese.
Mara Beveridge, MD
completed her undergraduate degree
in Biology magna cum laude at the
University of Pennsylvania, and completed
her medical degree at The University of
Chicago Pritzker School of Medicine. She
has volunteered as a Pritzker Admissions
Office student interviewer and as a class
representative on the Pritkzer Curriculum Review Committee. Mara
participates regularly in triathlons and plays the piano; she enjoys
cooking and traveling, and speaks Dutch and Spanish.
Adena Rosenblatt, MD, PhD
completed her undergraduate degree in
Biopsychology and Cognitive Sciences at
the University of Michigan, and attended
the University of Miami for her MD/PhD in
Molecular Pharmacology. She volunteered
as the team captain for Pedatric Olypmics
at the University of Miami, and taught
children in her capacity as a figure skating instructor in Ann Arbor.
Adena was awarded the Department of Defense Predoctoral Prostate
Cancer Fellowship, and enjoys skiing and theater.
PGY-5 Dermatopathology
Fellows:
Cindy L. Davis, MD, MEd
was a Navy daughter who traveled
extensively in the US and abroad as
a child. She received her Masters in
Education from the University of Florida
and worked for eight years as a highschool science teacher before turning to her
medical career, receiving her MD degree
from the University of Miami. After completing her residency in
Pathology at the University of Florida, she honed her diagnostic and
investigative skills there as a Clinical Postdoctoral Breast Pathology
Fellow. She has performed numerous research projects in various
aspects of pathology. She enjoys creating art through beadwork,
decorative painting, and stained glass.
10
Christopher Kinonen, MD
received his medical degree from Rush
University Medical Center. He completed
a medical internship at the University
of Chicago, and a year of residency in
Emergency Medicine at Stroger-Cook
County before transferring to Rush
University, he completed a residency in
Pathology. He also performed a Surgical Pathology Fellowship at
the University of Colorado. He has many projects and publications
to his credit in several areas of pathology. He has volunteered in
Chicago community and homeless health clinics, and enjoys skiing
and competitive cycling.
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Chicago Dermatological Society
Allan Lorincz Memorial Lecture
Steven R. Feldman, MD, PhD
Professor of Dermatology, Pathology & Public Health Sciences
Wake Forest University Health Sciences
Winston-Salem, NC
O
n December 8, 2012, the University of Chicago hosted the
Chicago Dermatological Society meeting, including the annual
Lorincz Memorial Lecture delivered by Dr. Steven R. Feldman. Dr.
Feldman’s lecture was entitled, “Tanning: An Addictive Behavior.”
Dr. Feldman completed his undergraduate education at the
University of Chicago in 1980. He earned his medical degree and PhD
from Duke University Medical Center. His residency training included
psychiatry and medicine at Duke University, dermatology at North
Carolina Memorial Hospital in Chapel Hill and dermatopathology at
the Medical University of South Carolina in Charleston.
Dr. Feldman has a clinical interest in psoriasis and has published
over 500 peer-reviewed articles. He is on the editorial board of the
Journal of the American Academy of Dermatology and Skin & Aging.
Dermatology Faculty Member
Goes Global
GLOBAL HEALTH DAY
Monday, October 22, 2012
Opportunities in Global Health
for Trainees and Health Professionals
Pam Aitchison, RN
Evan Lyon, MD
Funmi Olopade, MD
Nirav Shah, MD, JD
Aisha Sethi, MD
12:00-1:00pm
Box lunch will be provided
Medical Center
Billings Auditorium, P-117
A
isha Sethi, MD has increased her involvement in the Department
of Medicine’s Global Health Initiative (GHI) program. This
unique program continues a multidisciplinary approach reaching
across several Department Sections, as well as resourcing other
research, education and service areas University wide to accomplish
its mission. The mission of GHI is to collaborate with communities
locally and globally, democratize education, increase service-learning
opportunities, and advance innovative and sustainable solutions to
improve health and well-being. These themes were encapsulated
in the Global Health Day event held on campus on October 22nd
entitled “Opportunities in Global Health for Trainees and Health
Professionals.” The Keynote Lecture came from Melanne Verveer,
Ambassador-at-Large for Global Women’s Issues.
Keynote Lecture
Melanne Verveer
Ambassador-at-Large for Global Women’s Issues
4:00pm
Free and open to the public
Reception following the lecture
International House Assembly Hall
1414 East 59th Street
L to R: Dean Robert Armstrong of Aga Khan University
in Nairobi, Funmi Olopade, MD, FACP, OON,
Aisha Sethi MD and Sola Olopade, MD.
11
In Celebration:
Dr. Bernhard Ortel
Dr. Bernhard Ortel pictured here with Katie Burke, LPN
at the clinic luncheon.
I
n 2012, the Section bid
farewell to Dr. Bernhard Ortel
through a luncheon in the clinic
and an evening event held at the
Quadrangle Club on October
30th. Dr. Ortel was appointed to
full-time faculty in the Section
of Dermatology after graduating
from our residency program in
2008. His many contributions to
the University and his efforts to
establish a phototherapy clinic
WELCOME!
were recognized. At the reception
a presentation was given by Dr.
Shea and followed by colleagues
and staff offering their many
(often good-naturedly humorous)
anecdotes of working with Dr.
Ortel. He is currently in the
role of Head of Dermatology at
NorthShore University.
Photo Quiz
Q:
Why is Nurse Latoya
assuming this pose?
T
his year we welcomed a new administrator, Nishq Mody, to
the Section of Dermatology. Coming from a background in
managing federal, state, and county projects in Illinois, Nishq started
with us in January 2012. He has lived in several different countries
and throughout the United States over the years but considers
Illinois his home. His focus this year has been on navigating some
of the exciting changes occurring here at the University, from the
implementation of an EHR to the transition to a new practice plan,
while positioning the Section for growth in the coming year. In
his spare time he enjoys playing squash, chess, and working with
foundations & non-profit organizations in the field of education.
A: To demonstrate one of the standard poses patients
take when undergoing Mole Mapping photography.
12
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
Faculty in
the News
Skin Cancer
Screenings
Yu-Ying He, PhD
Vesna Petronic-Rosic, MD
Press Release: Research Highlight
in the UCCCC Fall edition of the
Pathways to Discovery newsletter,
“Tumor Suppressor Inhibits
Skin Cancer.”
Volunteer panel member for The
National Conference of State
Legislators (NCSL) Legislative
Summit and Skin Cancer Screening
Press Release: Research Highlight
in the UCCCC Winter edition of the
Pathways to Discovery newsletter,
“Researchers Discover How a Drug
Used in Transplant Patients Increases
Skin Cancer Risk.”
Aisha Sethi, MD
Featured in DOM Women
E-newsletter on Work-Life
Balance, May 2012
Published an article in the
Aga Khan University alumni
magazine (AKUNAMA) regarding
dermatology global health work and
career path in tropical medicine
The Section organized a series
of Skin Cancer Screenings in
partnership with the Skin Cancer
Foundation and/or the Chicago
Dermatological Society at various
Chicagoland locations throughout
the year. Merrillville Clinic, North
Avenue Beach and McCormick
Place and a mobile unit in Palos were
featured. The events were staffed
by Section faculty and housestaff.
Participants were given specially
created informational cards to
enhance the educational experience
of the encounter. These activities will
be an ongoing initiative.
Pictured above:
L to R: A. Ruiz deLuzuriaga, MD,
Edidiong Kaminska, MD, Adaobi
Nwaneshiudu, MD, Sarah Stein, MD,
Sogyong Auh, MD, and Bernhard
Ortel, MD.
Pictured below:
L to R: Jennifer Tang, RN, Adaobi
Nwaneshiudu, MD, Alexandria
Willis, Christopher R. Shea, MD,
Diana Bolotin, and Edidiong
Kaminska, MD.
13
AAD San Diego — March 17, 2012
S. Patel Wedding — July 27, 2012
B. Ortel’s Farewell — 10.30.12
TH E U N IV ERS IT Y OF CHICAGO
D E R M AT O L O G Y
AAD San Diego — March 17, 2012
S. Patel Wedding — July 27, 2012
B. Ortel’s Farewell — 10.30.12
BIOLOGICAL SCIENCES DIVISION
Dermatology
5841 South Maryland Avenue
MC 5067
Chicago, Illinois 60637
A
Please share your alumni
news, archival photos, or your
current contact information
with us.
University of Chicago
Section of Dermatology
5841 South Maryland Avenue
MC 5067
Chicago, Illinois 60637
Tel 773.834.2540
Fax 773.702.8398
s highlighted in our annual reports,
the progress in every aspect of our
academic program during the past decade has
been truly remarkable. The quality of care in
our modern clinic facilities is as high as any
major national academic center, and the more
vigorous teaching programs have all resulted
in the highest quality of residency applicants from the top medical schools.
Our basic science faculty have made major discoveries, as evidenced by
publications in the a very high impact scientific journals, presentations at
national and international scientific meetings, facilitating several major
extremely competitive NIH and American Cancer Society grants, as well
as a number of other awards. These achievements would not have been
possible without the continued generous support of our loyal alumni and
friends. I would like to personally thank each of you for your help and
advice. As you may know I am a donor as well as a faculty at the University
of Chicago. In addition to rather significant donations annually I have
designated a major amount by bequest for our program. In this era of major
cuts in research funds your continued support, advice and encouragement
are more crucial than ever. We have a number of endowed funds that you
can choose for your contributions. You can also start a new fund. Our faculty
pledge to continue doing their best to further improve all our academic
programs to make you proud of your alma mater. Please come to visit us and
get to know our residents, fellows and faculty whenever you get a chance.
Email: [email protected]
Keyoumars Soltani, MD
Professor of Medicine