In`Oss™

How to use it
Remove the blister from the sterile pouch.
In’Oss™ does not necessitate any mixing prior to placement. It is dispensed in a pre-mixed state
and can be placed directly into the defect site from the syringe. It can also be used as a graft
extender mixed with Allograft/Autograft.
In’Oss™ is not an hardening bone graft, complete closure with membrane or good sutures is
recommended during healing time.
Biomatlante Therapeutical Solutions
Option 1 : •••
Option 2 : ••
Association : •
MBCP+™
Osteogenic
Granules S
MBCP+™
Osteogenic
Granules L
MBCP™
Perio Gel
Micro Granules
In’Oss™
Putty
EZ Cure™
Membrane
IMPLANTOLOGY
Sinus lift Augmentation
In 2 steps - Minimum Crest Hight < 4-5mm
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In 1 step - Minimum Crest Hight < 5mm
with primary stability
Vertical Ridge Augmentation
Horizontal Alveolar Ridge Augmentation
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Alveolar regeneration - Extraction socket
Without implant placement
With implant placement
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PERIODONTOLOGY
Infra-osseus pockets
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Furcations
Dehiscences
Autograft Extender
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In’Oss
™
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MBCP™ Technology
Moldable Synthetic Bone Graft
References
1.
The safety and efficacy of an injectable bone substitute in dental sockets
demonstrated in a human clinical trial. Weiss P., Layrolle P., Clergeau LP., Enckel B.,
Pilet P., Amouriq Y., Daculsi G., Giumelli B., Biomaterials. 2007 Aug;28(22):3295305.
4.
A New Injectable Bone Substitute Concept (MBCP Gel ™): First Clinical Results
in Human Maxillo-Facial Surgery, Pierre Weiss, Léon Philippe Clergeau, Bénédicte
Enckel, Yves Amouriq, Bernard Giumelli, Alain Jean and Guy Daculsi, Key
Engineering Materials Vols. 284-286 (2005) pp. 1053-1056
2.
Maxillary Sinus Bone Grafting with an Injectable Bone Substitute: a Sheep Study, A.
Saffarzadeh, O. Gauthier, and al., Key Engineering Materials Vols. 254-256 (2004)
pp. 193-196
5.
Five Years Clinical Follow up Bone Regeneration with CaP Bioceramics Clemencia
Rodríguez, Alain Jean, and Guy Daculsi, Key Engineering Materials Vols. 361-363
(2008) pp. 1339-1342
3.
Tricalcium phosphate/hydroxyapatite biphasic calcium phosphate (BCP)
bioceramics , in Bioceramics and theirs clinical applications, Daculsi G., LeGeros R.,
T. Kokubo editor, Woodhead publishing, 2008, pp 395-4242
6.
Assessment of Cancellous Bone Architecture after Implantation of an Injectable
Bone Substitute, Catherine A. Davy, O. Gauthier, and al., Key Engineering Materials
Vols. 254-256 (2004) pp. 55-5842
Biomatlante
5 Rue Edouard Belin
44360 Vigneux de Bretagne
France
www.biomatlante.com
MBCP+™, MBCP™, In’Oss™ and Ez Cure™ are trademarks of Biomatlante
Distributed by:
FD2011022MD1
Manufacturer :
Microporous Resorbable
Biphasic Calcium Phosphate
In’Oss™
Moldable Synthetic Bone
Graft
Complete and progressive vital bone regeneration
Scaffold of choice for Alveolar Regeneration
Alveolar Regeneration with implant placement
Microporous Resorbable Biphasic Calcium Phosphate
In’Oss™ is an innovative and unique moldable bone
graft, made of MBCP™ Technology.
Developped to improve clinician handling during bone
grafting procedures, In’Oss™ can fit to the different size
and shape of the grafting sites.
In’Oss™, is an optimal balance between MBCP™ micro
granules and an absorbable hydrogel, acting as a carrier
for rapid vascularization and mineralization.
In’Oss™ preserves the original graft shape and bone
volume. It is gradually absorbed within a
few months and is replaced by vital
architectured bone.
In’Oss™ is ready to use
and avoid the hydratation
and manipulation phases.
Extraction, curettage and filling
4 Months Post Op – Dense bone observed with
MBCP Particles not completely absorbed
Good healing is observed for implant insertion 4
Months Post Op.
Implant is well stabilized in the newly formed
bone.
Control X-Ray showing the bone volume
obtained.
Unique Concept for Bone Augmentation
In’Oss™ is an interconnected microporous structure.
Hydrogel creates larges spaces between MBCP™ microporous particles to form
extra spaces for cells spreading and fluids diffusion.
In’Oss™ chemistry encourages the rapid formation of natural bone and the
growth of capillary blood vessels throughout matrix.
Stable Bone support for Implant placement.
These materials have been shown to be perfectly biocompatible and
absorbable.
4 months bone remodelling with
haversian system - Goat model
Moldable / Ready to use / Volume stable / Osteoconductive
Ready to use
Scaffold of choice for Sinus Augmentation
Sinus Augmentation with In’Oss™
In’Oss™ is supplied in sterile syringe ready to use. No pre-mixing is required
with blood or saline solution. In’Oss™ plasticity conforms to bone defect.
Safe
In’Oss™ Putty is safe and has excellent biocompatibility.
MBCP™ Bone Graft Particles have been the topic of extensive clinical studies
over the last 30 years with clinical results comparable to Autologous Bone.
Interconnected structure between the
microporous granules and hydrogel
Easy & Fast
Innovative Patent
MBCP™ microporous granules
In’Oss™ placement
Cells spreading
Sinus Elevation with implant placement in one
time
Bone window
Sinus filled with In’oss™
4 Months - Implants Placement
Primary stability is essential to make possible
association of bone graft and implants
placement.
4 Months - Control X-Ray showing the bone
volume obtained.
Hydrogel
Bony crystals precipitation
Architectured bone growth at the
expense of the bone graft
In’Oss™ - Microporous
Interconnected particules