What You Need To Know About Non-Surgical Sterilization With

What You Need To Know About Non-Surgical
Sterilization With Zeuterin™: Part II
Byron Maas, DVM
Medical Director
Ark Sciences, Inc.
Module III:
Post-Care Instructions
Physical Appearance Post-Injection
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Mild to moderate swelling of the testicles is an expected
reaction to the injection which you will notice within 24 - 48
hours after the injection
The dog's testicles may remain enlarged but non-painful for a
few months after the injection
Variable atrophy of the testicular tissue will be apparent
during palpation at 30-60 days post-injection
Physical Appearance Post-Injection
Post-Procedure Expectations
Setting the correct expectations for your client is
important, normal reactions include:
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Mild to moderate non-painful swelling
Mild listlessness for the first 24 hours
Some dogs may exhibit decreased appetite for the first
24 hours
Some dogs may vomit during the first 1-4 hours
Dog may sit with both hind legs open or change
positions frequently for the first several days
Post-Procedure Recommendations
To minimize the occurrence of adverse reactions, for
the first few days after injection:
1. It is critical that your clients closely monitor their dog's
activity post-injection and that they take all precautions
necessary to prevent injury to the testicles
2. Restrict the dog's exercise to leash walking
3. Do not allow the dog to run, jump, or engage in play
activity
4. Do not allow the dog to lay on hard or wet surfaces
5. Do not allow the dog to bite or lick the scrotum
Post-Procedure Recommendations
It is important to evaluate each patient individually
and advocate for patient comfort as indicated
1. Medicate for post injection pain and excessive
inflammation
2. Treat if signs of discomfort appear
3. Give anti-nausea medications as needed
4. Have good client communication to ensure best
outcome
Adverse Reactions
Have your clients contact you immediately if
they notice:
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The dog is biting or licking the scrotal area
Any signs of redness, discharge or broken skin in
the scrotal area
As this could be a sign that that the dog is experiencing a
possible adverse reaction, conservative medical
treatment, at the veterinarian’s discretion, is
recommended to first be attempted to help resolve any
medical concerns
Treating Minor Adverse Reactions
Biting
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and Licking:
E-Collar
Topical antibiotic ointment
Additional NSAID’s
Pain medication, if necessary
Case Study: Allergic Reaction
(facial edema)
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7 Months, 17.2 lbs, Sedation (TKX 0.4 IM)
Clinical signs presented 15 minutes postinjection
Benadryl Resolved within 1 hour
Case Study: Allergic Reaction
(angioedema and urticaria)
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6 Month old, 25 lbs, Sedation (TTDex IM)
Hydro 0.1 mg/kg IM at prep
Responded to Diphenhydramine and DexSP
injections, also given an injection of
Naloxone
Treating Ulcerations
Beginning signs of ulceration:
• Begin oral antibiotic
• Consider debriding ulcerated area depending
on severity
Nonresponsive scrotal ulcer:
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Consider castration or scrotal ablation if
necessary
Case Study: Ulceration
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11 mo. Boston Terrier, Wt. 16 lbs
PE -WNL
Sedation: Dex/Torb, NSAID: Meloxicam
Routine injection protocol followed
Owner noticed ulcer 6 days post injection
Case Study: Ulceration
Treatment: Evaluation, clean and flush the area,
antibiotics, additional NSAID, Tramadol
Case Study on Adverse Reaction
• 5 Month old, Poodle, Physical Exam WNL
• Resolved with conservative medical treatment
ADE 5 Hours
ADE Day 3
ADE Day 9
Case Study on Adverse Reaction
• 1.5 Year old, 41.2 lbs, Physical Exam WNL,
Sedation (TKX IM)
• Injected caudal aspect of testicle
• Castration and ablation
Module IV:
Communicating the Zeuterin™
Procedure with Your Clients
Shelter Medicine for
Veterinarians and Staff
Academic Presentations and Trainings
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Western University of Health Sciences
Tufts University
University of Illinois
University of Florida
Auburn University
Kansas State University
University of Minnesota
Michigan State University
University of Missouri
Mississippi State University
Louisiana State University
Why Do We Neuter Dogs?
To control population
Why Do We Neuter Dogs?
To decrease or eliminate certain diseases
What We Do Know
Testicular cancer in older intact dogs has a
reported incidence of 0.9%
Perianal tumors (adenoma and epithelioma)
constitute one of the most common canine
skin tumors
Benign prostatic hyperplasia
Surgical castration
favors progression
prostate carcinoma
Current
Research
Shows
Surgical castration
can increase joint
disorders
Surgical castration
can increases the
risk of obesity
Role of Testosterone
Cognition
Red Blood Cells
Cardiovascular Health
Muscle Mass
Bone Density
Zeuterin™ only reduces the
testosterone producing
function of Leydig cells,
keeping the critical
endocrine system intact
Without spermatogenesis,
the testosterone production
is reduced on average by
41-52%
Testosterone production
remains available for other
metabolic functions of the
dog
Why Do We Neuter Dogs?
To modify undesirable behaviors
Relinquishing Dogs
Reasons
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Owner-directed aggression
Stranger directed fear
Stranger directed aggression
Dog directed aggression
Spay/Neuter Status
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47.3% Spay/Neutered
52.7% Intact
Male/Female
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56.5% Male
43.5% Female
Evaluation of a behavioral assessment questionnaire for use in the
characterization of behavioral problems of dogs relinquished to animal
shelters. JAVMA, Vol 227, No. 11, December 1, 2005
Variables affect all
behavior:
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Breed
Environment
Training
Age of Sterilization
Courteous of James Serpell, PhD
University of Pennsylvania
Behavioral Assessment of
Child-Directed Canine Aggression
Key points:
“Although our data did not include age at neutering or whether
the surgery occurred before or after the appearance of
aggressive behavior, it is apparent that neutering does not
guarantee a reduction of aggression in dogs.”
Ilana R Reisner, Frances S Shofer, Michael L Nance:
Injury Prevention 2007;13:348–351.
Does Zeuterin™ Change Behavior?
The FDA behavior position statement:
“As with surgical castration, secondary male
characteristics (roaming, marking, aggression,
or mounting) may be displayed.”
What Does Change Behavior?
Aggression Issues
Aggression in Dogs
Breaking Up a Dogfight
Mouthing, Nipping and Play Biting
in Adult Dogs
Predatory Behavior in Dogs
Behavior Issues
Behavior Problems in Older Dogs
Behavioral Medications for Dogs
Charging Through Doors
Compulsive Behavior in Dogs
Destructive Chewing
Digging
Escaping from the Yard
Mounting and Masturbation
Puppy Mouthing
Socializing Your Puppy
Teaching Your Dog Not to Jump Up
on People
The Vocal Dog
Barking
Howling
Whining
Chasing Issues
Dogs Chasing Bicycles, Skateboards
and Other Moving Things
Dogs Chasing Cars
Dogs Chasing Cats
Dogs Chasing Children
Dogs Chasing Runners
Dogs Chasing Wildlife
Fear of Noises
Fear of Objects
Fear of Other Animals
Fear of People
Fear of Riding in Cars
Fear of Specific Places
Fear of the Veterinary Clinic
Neophobia (Fear of New Things)
Separation Anxiety
Eating Issues
Begging at the Table
Coprophagia (Eating Feces)
Counter Surfing and Garbage Raiding
Food Guarding
Foods That Are Hazardous to Dogs
Pica (Eating Things That Aren't Food)
Using Taste Deterrents
House Training
House Training Your Adult Dog
House Training Your Puppy
House Training Your Puppy Mill Dog
Medical Causes of House Soiling in Dogs
Teaching Your Dog to Eliminate in a
Specific Place
Submissive Urination
Teaching Your House Trained Dog to
Ask to Go Out
Urine Marking in Dogs
Fearful Dogs
Dogs Who Are Hand Shy
Dogs Who Are Sensitive to Handling
Fear of Children
Fear of Nail Trimming
Benefits of Implementing
Zeuterin™
Benefits of Implementing Zeuterin™
• Attractive Option to Surgical Neutering
• Free Up Surgical Suite
• Quick Recovery Time
• Increase Hospital Efficiency
• Potential to Attract New Clients
• Potential New Source of Income
Profile of Average Dogs in Recently
Conducted Study
Profile
Average
Age
2.0 years
Weight
33.36 lbs
Right Dose
0.63 mL
Left Dose
0.64 mL
Total mL
1.27 mL
1221 Dogs with treatments forms completed
Zeuterin™ Community Outreach:
Any time, anywhere, any climate
Can be used for:
• Community outreach programs
• Mobile services
• Vaccination clinics
Marketing Examples
Sharing the
News
Marketing
Zeuterin™ to
Clients
Prizes for Pioneers!
Share how you have incorporated Zeuterin™ into your veterinary practice, shelter, or
spay/neuter clinic, and you could win a spay/neuter grant up to $4,000!
ACC&D will compile and share these strategies to encourage creative and innovative
use of Zeuterin to:
• Make neutering more efficient and sterilize more dogs (male and female) while
expending fewer resources
• Reach communities without surgical facilities
• Neuter dogs whose owners resist surgical castration or who cannot safely undergo
anesthesia
• And more!
For more information, visit http://www.acc-d.org/get-involved/acc-d-zeuterin-contest.
Thank You Contest Sponsors!
Data Collection and
Dissemination
Zeuterin™ Treatment Form
Data Collection
• We ask Zeuterin™ Certified Veterinarians to submit all
treatment forms to Ark Sciences 30 days post-treatment
• In addition, if a dog is surgically castrated at a later date,
please send the testicular tissues to Ark Sciences for
histopathologic analysis
• We will be sharing information, trends and case studies with
our Certified Zeuterin™ Providers*
All information, trends, and case studies will be anonymous Ark Sciences will
never share your personal information without explicit consent
*
580 Dog Owners Share Why They
Choose Zeuterin
Other, 18%
Health Issues, 4%
Less-Invasive,
44%
Appearance, 4%
Fear of Anesthesia,
12%
Healthier/
Testosterone, 18%
Zeuterin™ Veterinarians
Green – Certified
Zeuterin™ Veterinarians
Blue – Pre-Trained
Green – Certified
Zeuterin™ Veterinarians
Blue – Pre-Trained
Green – Certified
Red – Training Centers
Next Steps
1. Contact Ark Sciences to schedule a Training Lab
2. Each vet/vet tech will need to inject at least 3 dogs to
complete the Zeuterin Certification process
3. The in-person Training Lab is $250/person or video
conferencing option is $150/person plus the cost of supplies
Supplies to be purchased for Training Lab
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Zeuterin*
• 28g or 30g needles
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Sedation
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1cc Luer Lock syringes*
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NSAID
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Caliper*
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Reversal agent
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Tattoo Pen* (optional)
* Available to purchase through Ark Sciences.
Zeuterin™ Training
Zeuterin™: It Works!
Fast • Safe • Effective • Permanent Neutering
Good for your practice • Great for your patients
It doesn’t have to be this way
Thank you and congratulations on taking the first
step towards becoming a Zeuterin™ Certified Provider
RACE Certification 2 CE Credits will be emailed to the
contact information provided
*Please register on the sign up form
Questions?
* Please come by Ark Sciences booth
* Register for in-hospital training
* AVMA special for regional training
*