Universiti Kebangsaan Malaysia

Rahman Jamal
MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore)
PJN, DPNS, ANS
Universiti Kebangsaan Malaysia
[email protected]
[email protected]
RESEARCH CLUSTERS
CANCER AND
STEM CELL
MECHANISM OF
DISEASES
ANTIOXIDANTS
& METABOLISM
REGENERATIVE
MEDICINE
HEALTH AND
MEDICAL
TECHNOLOGY
NICHE
BIOMEDICAL
ENGINEERING
BIOACTIVE
NATURAL
PRODUCTS
HEALTH AND
BURDEN OF
DISEASES
Strong representation across
many faculties
 Researchers from
 Faculty of Medicine
 Faculty of Health Sciences
 Faculty of Dentistry
 Faculty of Pharmacy
 Faculty of Engineering
 Faculty of Science and Technology
 UKM Medical Molecular Biology Institute
Key strengths (I):
Mainly basic and translational
Anti-oxidants
Bone
Neuro
Cancer
Tissue
engineering
Health
Economics
Epidemiology:
NCDs
Ageing
Toxicology &
environmental
health
Nutrition &
dietetics
Energy and
physical
activity
Drug discovery
& natural
products
Drug delivery
Dental
research
Rehabilitation
Audiology &
speech
Key strengths (II): Mainly clinical
plus some basic research
Endocrinology
Cardiology
Orthopaedics
ENT (hearing &
(diabetes,
hypertension)
(angio, ECHO,
myocardial
infarction)
Neurology
(epilepsy, stroke,
Parkinson’s)
Psychiatry
(rehabilitation,
tissue engineering)
Cochlear Implant)
(sexual dysfunction,
depression)
Surgery (breast,
O&G (feto-
Opthalmology
thyroid, urology,
colorectal)
maternal &
diabetes)
(retinal diseases)
Cardiovascular diseases:
Predictors for CVS risk
Augmentation
index, Vasera
analysis, etc.
Identification of
ECG predictors
or arrhythmias
Validation of a
70-gene cardiac
panel
Protective
variants for HDL
and LDL
Prof. Oteh Maskon, Dr. Azian Murad, Prof. Rahman Jamal,
Dr. Syakima Ab Mutalib, et al.
Obesity: Risk factors,
assessment & physical activity
FFQ and
nutritional
status
Eating practices,
sleep habits,
physical activity
Large-scale
validation of
variants
BMI and
mortality,
cancers, etc.
Prof. Suzana Sahar, Prof. Poh Bee Koon, Dr. Azian Murad,
Prof. Rahman Jamal, et al.
Diabetes
Predictive markers
for complications
(nephropathy, etc.)
Intervention for
pre-diabetes in the
rural settings
Natural Products
CVS risk and
metabolic
syndrome
Prof. Norazmi Kamaruddin, Prof. Halim Ghafur, Prof. Wu Loo Ling,
Prof. Norlaila Mustafa, Prof. Ibrahim Jantan, Prof. Shamsul Azhar, et al
1000-Malaysian Genomes:
Cancer and Rare Diseases
Integrated analysis:
Genomics,
transcriptomics,
proteomics
Biomarker
discovery using the
Cohort samples
Next-generation
sequencing of
cancers
NGS and exome
sequencing of rare
diseases
Prof. Rahman Jamal, Prof. Syed Zulkifli, Prof. Zarina Abd Latiff,
Prof. Lokman Mohd Noh, Prof. Isa Rose, Dr. Syakima Ab Mutalib, et al
The Malaysian Cohort:
An innovative population laboratory
GIS coordinates for 106,527
participants

44 % Malays (•), 33% Chinese (•),
15% Indians (•), 8% others (•)
• Demographic data
• Environmental exposure
• Biophysical data
• Biospecimens
•Menggunakan
Follow-up
data (after 5 years)
Aplikasi Geographical Information System (GIS), Arch GIS 9.0
Jamal et al, Int J Epid 2014
Mortality due to cancers
Types of cancer
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
Lung cancer
Breast cancer
Hepatoma/ Liver cancer
Colorectal cancer
Stomach/ Gastrointestinal Stromal Tumor (GIST)
Pancreatic cancer
Nasopharyngeal cancer
Unknown cancer
Brain cancer
Lymphoma/ Non-Hodgkin Lymphoma (NHL)
Leukemia
Ovarian cancer
Cervical cancer
Thyroid cancer
Renal cell carcinoma
Uterine/ endometrium cancer
Osteosarcoma/Bone cancer
Oral cancer
Prostate cancer
Bladder cancer
Others
TOTAL
Januari 2015
Frequency
84
69
47
34
29
22
22
22
19
17
17
16
13
9
8
5
4
4
3
3
15
462
Percent
18.2
14.9
10.2
7.4
6.3
4.8
4.8
4.8
4.1
3.7
3.7
3.5
2.8
1.9
1.7
1.1
0.9
0.9
0.6
0.6
2.2
100%
Biobank: Largest in SEA
• Main Biobank
• 2 satellite Biobanks
(as back-up)
Primary Immunodeficiency
Disorders (PID)
 1:1200
 Objectives
 Unraveling association of
genetic and functional
immune studies of PID from
Malaysian patients
 Methods
 Immunological tests
 Whole exome sequencing
 Whole genome sequencing
 Principal investigator
 Prof. Lokman Mohd Noh
 Co-researchers
 Prof. Zarina Abd Latiff
 Prof. Rahman Jamal
 UK Collaborators
 Prof. Helen Chapel (Oxford)
Co-morbidity of NCDs and
Infectious Diseases
Helicobacter pylori
and gastric cancer
(Dr. Alfizah Hanafiah)
Diabetes and
meloidosis
(Prof. Dr. Sheila Nathan)
The Malaysian
Microbiome in
health and disease
(Dr. Neoh Hui Min)
Wellness and ageing
Anti-oxidants &
degenerative
diseases
(Prof. Suzana Makpol)
Regenerative
medicine
(Prof. Ruszymah
Idrus)
Bone health &
metabolism
(Prof. Ima Nirwana
Sulaiman)
Dental Health
(Assc. Prof. Tuti
Ningseh)
Nutrition and
physical activity
(Prof. Suzana Shahar)
Health
Economics
(Prof. Sharifah Ezat)
Neurosciences
Parkinson’s
disease
(Prof. Norlinah Ibrahim)
Bipolar disease
& schizophrenia
(Assc. Prof. Chan Lai Fong)
Stroke
(Prof. Norlinah Ibrahim)
Epilepsy
(Prof. Dato Raymond
Azman Ali)