W - XVIth International Symposium on Retinal Degeneration
Transcription
W - XVIth International Symposium on Retinal Degeneration
XV INTERNATIONAL SYMPOSIUM ON RETINAL DEGENERATION RD2012 July 16 -‐ 21, 2012 Bad Gögging, Bavaria, Germany International Organizing Committee Joe G. Hollyfield Christian Grimm Robert E. Anderson Matthew M. LaVail Catherine Bowes Rickman John D. Ash Local Organizing Committee Bernhard Weber Ernst Tamm Olaf Strauss Administrative Coordinators Holly Whiteside Barbara Gareis Satellite Symposium of The XX Biennial Meeting of the International Society for Eye Research Young Investigator Travel Awards The organizers of RD2012 congratulate the individuals listed below as recipients of RD2012 Young Investigator Travel Awards funded by the National Eye Institute, NIH, USA; the Foundation Fighting Blindness, USA; Pro Retina Germany; and the Fritz Tobler Foundation, Switzerland. Eligibility was restricted to graduate students, postdoctoral fellows, instructors and assistant professors actively involved in retinal degeneration research. These awards were based on the quality of the abstract submitted by each applicant. Catherine Bowes Rickman chaired the Travel Awards Committee of eleven senior retinal degeneration investigators. Marijana Samardzija University of Zürich Zürich, Switzerland Vanda Lopes University of Coimbra Portugal Matthew Campbell Trinity College Dublin Dublin, Ireland Kerstin Nagel-‐Wolfrum Johannes Gutenberg University Mainz, Germany Ema Ozaki Trinity College Dublin Dublin, Ireland Cavit Agca University of Zürich Zürich, Switzerland Alexander Aslanidis University of Regensburg Regensburg, Germany Felix Grassmann University of Regensburg Regensburg, Germany Ulrich Luhmann UCL Institute of Ophthalmology London, UK Marcus Karlstetter University Hospital of Cologne Cologne, Germany Tembei Forkwa University of Regensburg Regensburg, Germany Emeline Nandrot Institut de la Vision Paris, France Alison Reynolds University College Dublin Dublin, Ireland Chloe Stanton University of Edinburgh MRC IGMM Edinburgh, Scotland Frank Zach University of Regensburg Regensburg, Germany Barbara Maria Braunger University of Regensburg Regensburg, Germany Travel Awards Pro Retina Germany Awardees 2 Young Investigator Travel Awards Fritz Tobler Foundation Awardees Jindong Ding Duke University Medical Center Durham, USA Peter Westenskow The Scripps Research Institute La Jolla, USA Toshihidi Kurihara The Scripps Research Institute La Jolla, USA Alex Woodell Medical University of South Carolina Charleston, USA Sreemathi Logan University of Oklahoma HSC Oklahoma, USA David Rabin Albany Medical College Albany, USA Joseph Fogerty Medical College of Wisconsin Milwaukee, USA Julian Esteve-‐Rudd Jules Stein Eye Institute Los Angeles, USA Gloriane Schnabolk Medical University of South Carolina Charleston Yingbin Fu University of Utah Salt Lake City, USA Gregory Grossman Cole Eye Institute Cleveland, USA Heike Kroeger University of California, San Diego San Diego, USA Aparna Lakkaraju University of Wisconsin-‐Madison Madison, USA Nora Caberoy University of Miami Miami, USA Theodore Drivas University of Pennsylvania Philadelphia, USA Saravanan Kolandaivelu West Virginia University Morgantown, USA Sem Genini University of Pennsylvania Philadelphia, USA Katayoon Ebrahimi Johns Hopkins University Baltimore, USA Vera L. Bonilha Cole Eye Institute Cleveland, USA Travel Awards NEI Awardees 3 Young Investigator Travel Awards Jonathan Lin University of California La Jolla, USA Astra Dinculescu University of Florida Gainesville, USA Daniel Adesse University of Rio de Janeiro Rio de Janeiro, Brazil Travis Bailey University of Notre Dame Notre Dame, USA Xi-‐Qin Ding University of Oklahoma HSC Oklahoma, USA Lea Marchette University of Oklahoma HSC Oklahoma, USA Linda Ruggiero Fordham University New York, USA Houbin Zhang University of Utah Salt Lake City, USA Timothy Day University of California, Berkeley Berkeley, USA John Fuller Johns Hopkins University Baltimore, USA Anh Thi Nguyen Trinity College Dublin Dublin, Ireland Michelle Grunin Hebrew Univ / Hadassah Ein Kerem Med Ctr Jerusalem, Israel Martin-‐Paul Agbaga University of Oklahoma HSC Oklahoma, USA Hong Hao National Institutes of Health Bethesda, USA Zongchao Han University of Oklahoma HSC Oklahoma, USA Preet Subramanian National Eye Institute Bethesda, USA Leah Byrne University of California, Berkeley Berkeley, USA Marina Gorbatyuk University of North Texas HSC Fort Worth, USA Xue Cai University of Oklahoma HSC Oklahoma, USA Stefanie Hauck Helmholtz Zentrum Munich Munich, Germany Frank Dyka University of Florida Gainesville, USA Travel Awards Foundation Fighting Blindness Awardees 4 Schedule & Platform Sessions Monday, July 16, 2012 15:00 -‐ 18:00 Registration Desk, delegates to pick up programs and name badges as well as set up posters 17:00 -‐ 18:00 WELCOME RECEPTION 18:00 -‐ 18:15 Welcoming Remarks 18:15 -‐ 19:00 Plenary Lecture I: V. MICHAEL HOLERS, MD Context-‐Specific Roles for Complement in Innate and Adaptive Immune Responses introduced by Joe G. Hollyfield 19:15 -‐ 21:00 WELCOME DINNER BUFFET Monday 5 Schedule & Platform Sessions Tuesday, July 17, 2012 06:30 -‐ 08:00 BREAKFAST 08:00 -‐ 08:45 Plenary Lecture II: FREDERIC GEISSMANN, MD, PhD Origin of myeloid cells introduced by Olaf Strauss 08:45 -‐ 10:00 Platform Session I: AMD and Complement activation I Moderators: Debra A. Thompson & Olaf Strauss 08:45 -‐ 09:15 Aparna Lakkaraju, Jin Xu, Kimberly A. Toops Maintaining membrane integrity in the retinal pigment epithelium: critical roles of complement regulatory proteins and lysosome trafficking 09:15 -‐ 09:45 Baerbel Rohrer, Kannan Kunchithapautham, Andreas Genewski, Olaf Strauss Prolonged voltage-‐gated calcium channel activation by sublytic complement activation in retinal pigment epithelium, a mechanism for controlling VEGF secretion 09:45 – 10:00 Joseph Fogerty, Joseph C. Besharse Complement regulation in Mfrp174delG mice, a model for advanced dry AMD 11:00 -‐ 11:30 Matt V. Rutar, Rizalyn Albarracin, Krisztina Valter, Riccardo Natoli, Jan Provis Near-‐infrared treatment reduces complement propagation in a light-‐induced model of atrophic AMD 11:30 -‐ 12:00 Michelle Grunin, Tal Burstyn-‐Cohen, Shira Hagbi Levi, Amnon Peled, Itay Chowers Characterizing Monocyte Recruitment Signals In White Blood Cells from Patients with Age-‐Related Macular Degeneration 6 Tuesday 10:00 -‐ 11:00 POSTERS & COFFEE 11:00 -‐ 12:30 Platform Session II: AMD and Complement activation II Moderators: Janet C. Blanks & Breandan Kennedy Schedule & Platform Sessions 12:00 -‐ 12:15 Katayoon Ebrahimi, Natalia Fijalkowski, Marisol Cano, James T. Handa Oxidized Low Density Lipoprotein-‐Induced Injury in Retinal Pigment Epithelium Alters Expression of the Transmembrane Complement Regulatory Factors CD46 and CD59 through Exosomal and Apoptotic Bleb Release 12:15 -‐ 12:30 Jindong Ding, Una Kelly, Marybeth Groelle, Catherine Bowes Rickman Chronic complement inhibition damages the mouse retina 12:30 -‐ 14:00 LUNCH 14:00 -‐ 15:30 Platform Session III: AMD and Genetics Moderators: Catherine Bowes Rickman & Bernhard Weber 14:00 -‐ 14:30 Stephanie A. Hagstrom, Gui-‐shuang Ying, Gayle J. Pauer, Gwen M. Sturgill-‐ Short, Jiayan Huang, Maureen G. Maguire, Daniel F. Martin Pharmacogenetics of Anti-‐VEGF Therapy in the Comparison of AMD Treatments Trials (CATT) 14:30 -‐ 15:00 Anneke den Hollander, Dzenita Smailhodzic,Philipp Muther, John Chen, Jeroen Klevering, Robert Koenekoop, Sascha Fauser, Carel Hoyng Cumulative Effect of High Risk Alleles in CFH, ARMS2 and VEGF on Response to Ranibizumab Treatment in Age-‐Related Macular Degeneration 15:00 -‐ 15:15 Felix Grassmann, Lars G. Fritsche, Claudia N. Keilhauer, Iris M. Heid, Bernhard H.F. Weber Modelling the Genetic Risk in Age-‐Related Macular Degeneration 15:15 -‐ 15:30 Chloe M. Stanton, Elod Kortvely, Caroline Hayward, Marius Ueffing, Alan F. Wright The serine protease HTRA1 is a potential regulator of the inflammatory cytokine GDF15 Tuesday 15:30 -‐ 16:30 POSTERS & COFFEE 7 Schedule & Platform Sessions 16:30 -‐ 18:00 Platform Session IV: Therapeutic interventions I Moderators: Silvia Finnemann & Ernst Tamm 16:30 -‐ 17:00 William A. Beltran, Artur A. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Anand Swaroop, William W. Hauswirth, Samuel Jacobson, Gustavo D. Aguirre Photoreceptor structure and function are rescued following AAV Mediated Gene Transfer of Human RPGR in Canine Models of XLRP 17:00 -‐ 17:30 Kathryn E. Klump, Sudipta Seal, James F. McGinnis Effects of Catalytic Antioxidant Nanoparticles on Retinal Pigment Epithelium and Photoreceptor Structure and Function in the VLDLR -‐/-‐ mouse 17:30 -‐ 17:45 Peter D. Westenskow, Toshihide Kurihara, Tongbiao Zhao, Edith Aguilar, Iacovos Michael, Andras Nagy, David A. Cheresh, Yang Xu, Martin Friedlander Utilizing induced pluripotent cell derived RPE and exogenous delivery of anti-‐ miR-‐132 to treat symptoms of dry and wet AMD 17:45 -‐ 18:00 Alison L. Reynolds, Yolanda Alvarez, Carmel McVicar, Alan Stitt, Breandan N. Kennedy Discovery of two novel anti-‐angiogenic compounds in zebrafish 18:00 -‐ 18:45 Plenary Lecture III: SCOTT COUSINS, MD The Savage Macrophage: the role of blood-‐derived macrophages in the pathobiology of AMD introduced by Catherine Bowes Rickman 19:00 -‐ 21:00 DINNER BUFFET Tuesday 20:00 -‐ 22:00 POSTERS & BEER 8 Schedule & Platform Sessions Wednesday, July 18, 2012 06:30 -‐ 08:00 BREAKFAST FULL DAY EXCURSION 08:30 Departure by bus from Monarch Hotel to Regensburg 09:30 -‐ 11:00 Guided tour through Regensburg “Experience a Historic City” Meeting the guides at the bus terminal ‘Stadtamhof’ Several groups (max. 25 persons/group) 11:00 Appointment with Mayor at ‘Altes Rathaus’ appr. 11:45 Lunch incl. one drink at ‘Haus Heuport’, Regensburg 15:00 Departure by bus to Kelheim 16:15 -‐ 17:00 Ship tour from Kelheim to Weltenburg Abbey Beer degustation and brezn on the boat 17:00 Welcome by the Stadtmaus-‐Guides, All groups meeting in the church 17:50 Guided tour through Weltenburg in groups of 50 persons each One children’s group with special program! appr. 19:00 Departure by bus to Monarch Hotel DINNER BUFFET at the Monarch Hotel Wednesday 9 Schedule & Platform Sessions Thursday, July 19, 2012 06:30 -‐ 08:00 BREAKFAST 08:00 -‐ 08:45 Plenary Lecture IV: PAUL McMENAMIN, MD, DSc Perturbations in the arrangement and phenotype of myeloid-‐ derived cells in the retina in response to aging, hyperglycemia, exposure to TLR ligands and the rd8 mutation of the Crb1 gene introduced by Bernhard Weber 08:45 -‐ 10:00 Platform Session V: Mechanisms of Degeneration I Moderators: Goldis Malek & Eric A. Pierce 08:45 -‐ 09:15 Ana I. Arroba, Noemí Álvarez-‐Lindo, Nico van Rooijen, Enrique J. de la Rosa A dual role of microglia in the rd10 mouse model of Retinitis Pigmentosa and its modulation by IGF-‐I 09:15 -‐ 09:30 Ulrich F. O. Luhmann, Clemens A. Lange, Scott Robbie, Peter M.G. Munro, Jill A. Cowing, Hannah Armer, Vy Luong, Livia S. Carvalho, Robert E. MacLaren, Frederick W. Fitzke, James W.B. Bainbridge, Robin R. Ali Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling 09:30 -‐ 09:45 Vera L. Bonilha, M.E. Rayborn, C. Xie, H. Cai DJ-‐1 role in oxidative stress in mice retinas 09:45 -‐ 10:00 Lea D. Marchette, Robert E. Anderson Photoreceptor Dysfunction Precedes Degeneration in Mouse Retinas Depleted of Very Long Chain Polyunsaturated Fatty Acids Thursday 10:00 -‐ 11:00 POSTERS & COFFEE 10 Schedule & Platform Sessions 11:00 -‐ 12:30 Platform Session VI: Mechanisms of Degeneration II Moderators: Jacque L. Duncan & Steven J. Fliesler 11:00 -‐ 11:30 Minhua Wang, Wai T. Wong Microglia-‐Müller Cell Interactions in Retinal Inflammation 11:30 -‐ 12:00 Marina Gorbatyuk, Shreyasi Choudhury Reprogramming of the downstream UPR marker caspase-‐7 prevents vision loss in T17M Rho transgenic mice 12:00 -‐ 12:30 Robert Mullins, Desi P. Schoo, Edwin M. Stone Pathophysiology of the Choriocapillaris in AMD 12:30 -‐ 14:00 LUNCH 14:00 -‐ 15:30 Platform Session VII: Signaling I Moderators: Bela Anand-‐Apte & Christian Grimm 14:00 -‐ 14:30 John D. Ash, Lei Xu Activation of AMPK protects photoreceptors from light damage by preventing oxidative stress, and requires signaling through gp130 and STAT3 14:30 -‐ 15:00 Xian-‐Jie Yang, Kun-‐Do Rhee, Carrie Zhao, Dean Bok CNTF-‐mediated Neuroprotection in a Mouse Model of Retinitis Pigmentosa Requires Cytokine Receptor gp130 in Müller Glial Cells 15:00 -‐ 15:15 Cavit Agca, Pawel Pelczar, Christian Caprara, Monika Bauer, Melanie Maudrich, Ghislaine Traber, Christel Beck, Isabelle Meneau, Christian Grimm Regulation of Lif mRNA stability in Muller cells 15:15 -‐ 15.30 Stefanie M. Hauck, Christine von Toerne, Patricia del Río, Jennifer Behler, Joanna Kucharska, Marius Ueffing The neuroprotective potential of Müller glial cells Thursday 15:30 -‐ 16:30 POSTERS & COFFEE 11 Schedule & Platform Sessions 16:30 -‐ 18:00 Platform Session VIII: Signaling II Moderators: Machelle T. Pardue & Martin-‐Paul Agbaga 16:30 -‐ 17:00 David R. Hyde, Craig M. Nelson, Kristin Ackerman, Patrick O'Hayer, Francis Raycroft Tumor Necrosis Factor-‐alpha Is a Signal from Dying Photoreceptors to Initiate Müller Glia Proliferation in the Regenerating Zebrafish Retina 17:00 -‐ 17:30 Xiaoman Li, Timothy M. Boyce, Henna Iqbal, M. Suhaib Khan, M. Nawajes Mandal, Nanette Wheatley, Michelle C. Callegan, Daniel J. Carr, Michael H. Elliott Paradoxical role of caveolin-‐1 in retinal inflammation 17:30 -‐ 18:00 Preeti Subramanian, Yuqin Yin, S. Patricia Becerra Identification of a Functional Exodomain of Pigment Epithelium-‐derived Factor Receptor Critical for Neurotrophic Activity 18:00 -‐ 18:45 Plenary Lecture V: THOMAS LANGMANN, PhD Microglia and retinal degeneration: a target for therapy? introduced by Ernst Tamm 19:00 -‐ 21:00 DINNER BUFFET 20:00 -‐ 22:00 POSTERS & BEER Thursday 12 Schedule & Platform Sessions Friday, July 20, 2012 06:30 -‐ 08:00 BREAKFAST 08:00 -‐ 08:45 Plenary Lecture VI: CHI-‐CHAO CHAN, MD Molecular pathology of macrophage and IL-‐17 in AMD introduced by John D. Ash 08:45 -‐ 10:00 Platform Session IX: RPE I Moderators: Roxana A. Radu & John D. Ash 08:45 -‐ 09:15 Matthew Campbell, Sarah L. Doyle, Ema Ozaki, Robert G. Salomon, Andres Mori, Paul F. Kenna, Anna-‐Sophia Kiang, Marian M. Humphries, Ed C. Lavelle, Luke A.J. O’Neill, Joe G. Hollyfield and Peter Humphries NLRP3 plays a protective role during the development of age related macular degeneration through the induction of IL-‐18 by drusen components 09:15 – 09:45 Tim U. Krohne, Carolina Brandstetter, Jürgen Kopitz, EickeLatz, Frank G. Holz Activation of the NALP3 inflammasome induced by lipofuscin phototoxicity and lysosomal membrane permeabilisation in the RPE 09:45 – 10:00 Bruban Julien, Naima Chalour, Florian Sennlaub, Francine Behar-‐Cohen, Agathe Maoui, Na An, Virginie Dinet, Frédéric Mascarelli Effects of inflammation and an anti-‐inflammatory therapy during amyloid-‐β-‐ induced retinal degeneration 11:00 -‐ 11:30 Olaf Strauss, Vladimir Milenkovic, Nestor Mas Gomez, Claudia Müller, Andrea Milenkovic, Elena Röhrl, Bernhard H.F. Weber Localization matters: the function of disease-‐causing bestrophin-‐1 mutations 11:30 -‐ 12:00 Douglas Vollrath, David J. Strick, Rui Chen, Michael Snyder A cell culture model of mTOR-‐mediated RPE dedifferentiation 13 Friday 10:00 -‐ 11:00 POSTERS & COFFEE 11:00 -‐ 12:30 Platform Session X: RPE II Moderators: Patsy Nishina & Orson Moritz Schedule & Platform Sessions 12:00 -‐ 12:15 Julian Esteve-‐Rudd, Concepcion Lillo, Tanja Diemer, Vanda Lopes, David S. Williams Role of kinesin-‐1 in the retinal pigment epithelium 12:15 -‐ 12:30 Emeline F. Nandrot, Célia Parinot, Jonathan Chatagnon, Ah-‐Lai Law Soluble MerTK release helps downregulating POS phagocytosis by RPE cells in culture 12:30 -‐ 14:00 LUNCH 14:00 -‐ 15:30 Platform Session XI: Therapeutic intervention II Moderators: Valeria Marigo & T. Michael Redmond 14:00 -‐ 14:30 Don Zack, Gillian Shaw, Zhiyong Yang, Tom Johnson, John Fuller, Cynthia Berlinicke, Derek Welsbie, Xinrong Zhou, Jie Fu, Justin Hanes, Douglas Yasumura, Michael Matthes, Matthew M. LaVail Sunitinib, a broad-‐spectrum receptor tyrosine kinase inhibitor, is highly neuroprotective for photoreceptors 14:30 -‐ 15:00 Michael Iuvone, Gianluca Tosini, Keqiang Ye N-‐Acetylserotonin: Circadian activation of the BDNF receptor and neuroprotection in the retina 15:00 -‐ 15:15 Anh Thi Hong Nguyen, Matthew Campbell, Marian M. Humphries, Anna-‐ Sophia Kiang, Paul F. Kenna, Peter Humphries Prevention of autosomal dominant retinitis pigmentosa in P23H rats by systemic administration of 17DMAG, an Hsp90 inhibitor 15:15 -‐ 15.30 Leah C. Byrne, Deniz Dalkara, Jose Sahel, Thierry Leveillard, John G. Flannery AAV-‐mediated delivery of RdCVF and RdCVFL in a mouse model of rod-‐cone dystrophy Friday 15:30 -‐ 16:30 POSTERS & COFFEE 14 Schedule & Platform Sessions 16:30 -‐ 18:00 Platform Session XII: Protein networks Moderators: Janet R. Sparrow & Scott Plafker 16:30 -‐ 17:00 Roswitha Seitz, Sebastian Albrecht, Ernst R. Tamm, Andreas Ohlmann Norrin interacts with TGF-‐β signaling in vitro and in vivo 17:00 -‐ 17:30 Uwe Wolfrum Usher syndrome protein network functions in the retina and their relation 17:30 -‐ 18:00 Jonathan H. Lin Selective activation of the IRE1, ATF6, and PERK signaling pathways of the Unfolded Protein Response prevent mutant rhodopsin accumulation in cells 18:00 -‐ 18:15 Welcome to RD2014 – Matt LaVail / Catherine Bowes Rickman 20:00 -‐ 23:30 GALA DINNER Saturday, July 21, 2012 Friday & Saturday 06:30 -‐ 10:00 BREAKFAST INDIVIDUAL DEPARTURE 15 RD2012 Poster Presentations Poster setup: All posters should be mounted on Monday, July 16th, or before 08:00 on Tuesday July 17th. Poster removal: Posters are displayed all week. Posters should be removed after the afternoon session on Friday, July 20th. Poster Schedule: Presenting authors of a poster with an ODD number should be available in front of the poster during the MORNING sessions. Authors of a poster with an EVEN number should present their data during AFTERNOON sessions. Everybody is free to roam all posters during night sessions (POSTERS & BEER). Note: Presenting authors are underlined; Travel Awardees are shown in bold 1. Oxidative insult mediated retinal inflammation is exaggerated in CX3CR1 deficient mice and is related to the development of retinal geographic atrophy Mei Chen, Chang Luo, Heping Xu 2. IGF1R Genetic Polymorphisms Affect Risk Of AMD And Predispose Obese People To Higher Risk Chung-‐Jung Chiu, Yvette Conley, Michael B. Gorin, Gary Gensler, Chao-‐Qiang Lai, Fu Shang, Allen Taylor 3. Complement Component-‐3 (C3) Gene Mutations in Patients with Basal Laminar Drusen, a Clinical Subtype of Age-‐Related Macular Degeneration Maheswara Duvvari, Johannes P. H. van de Ven, Frederieke E. Schoenmaker-‐Koller, Carel B. Hoyng, Anneke I. den Hollander 4. Choroidal Findings in Reticular Pseudodrusen Amani A. Fawzi, Mahsa Sohrab, Jeannie Chen 5. Characterization of early-‐onset drusen in cynomolgus monkeys and an attempt to suppress drusen formation by complement inhibitors Takeshi Iwata, Zai-‐Long Chi, Yuriko Minegish, Tsunehiko Yoshida, Hiroaki Kobayashi, Mao Nakayama, Kaoru Fujinami, Yozo Miyake, Atsushi Mizota, Yuko Katakai, Michihiro T. Suzuki, Nobuhiro Shinozawa, Yasuhiro Yoshikawa, John D.Lambris 6. Genetic Association of Glucose Transporter Type 1 Variants with Age-‐Related Macular Degeneration and its Direct Interaction with Complement Factor H at the Protein Level Elod Kortvely, Anneke I. den Hollander, Gorza Matteo, Sascha Fauser, Alan F. Wright, Caroline Hayward, Valentina Cipriani, John R.W. Yates, Carel B. Hoyng, Marius Ueffing 7. Sphingolipids as mediators of ocular inflammation Nawajes A. Mandal, Hui Chen, Donald U. Stone, Daniel J. Carr, Annie Y. Chan 8. Measuring Changes in Cone Density in a Japanese Macaque Model of Age Related Macular Degeneration with Commercially Available Adaptive Optics Mark E. Pennesi, Keith D. Michaels, Anupam K. Garg, Jonathan D. Fay, Ellie N. Chegarnov, Allison R. Weiss, Laurie M. Renner, Trevor J. McGill, Kay D. Rittenhouse, Marvin Sperling, Joachim Fruebis, Martha Neuringer 9. Chronic Oxidative Stress Can Up-‐regulate Drusen-‐related Protein Synthesis in Primary Human RPE Cells: A Novel Culture Model for Dry Age-‐Related Macular Degeneration 16 All Week AMD, Complement activation and Immune reaction RD2012 Poster Presentations David M Rabin, Richard L Rabin, Timothy A Blenkinsop, Sally Temple, Jeffrey H Stern 10. Initiating triggers for age-‐related macular degeneration and RPE immunoreactivity as a function of complement factor H genotype Roxana Radu, Jane Hu, Zhichun Jiang, Dean Bok 11. The alternative complement cascade mediates functional and morphological deficits in a smoke model of age-‐related macular degeneration. Alex Woodell, Beth Coughlin, Kannan Kunchithapautham, Tucker Williamson, Carl Atkinson, William Ferrell, Bryan Jones, Bärbel Rohrer Genetics 12. Retina-‐specific expression of Kcnv2 is controlled by Cone rod homeobox (Crx) and Neural leucine zipper (Nrl) Alexander Aslanidis, Marcus Karlstetter, Yana Walczak, Herbert Jägle, Thomas Langmann 13. Application of Next-‐Generation Sequencing to Identify Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa (adRP) Stephen P. Daiger, Sara J. Bowne, Lori S. Sullivan, Susan H. Blanton, George M. Weinstock, Daniel C. Koboldt, David Larsen, Peter Humphries, Marian M. Humphries, Eric Pierce, Rui Chen, Yumei Li 14. Exome analysis identified a novel mutation in the CDHR1 gene in a family with recessive retinal degeneration Jacque L. Duncan, Austin Roorda, Mili Navani, Sangeetha Vishwesvaraiah, Reema Syed, Shiri Soudry, Kavitha Ratnam, Harini V. Gudiseva, Pauline Lee, Terry Gaasterland, Radha Ayyagari 15. GNAQ and GNA11 Mutations in Uveal Melanomas in the Chinese Population Weimin He, Ling Zhao, Qingli Luo, Jiagang Zhao, Jing Luo, Louise Mao, Kang Zhang 16. Phenotypic conservation in patients with x-‐linked retinitis pigmentosa caused by rpgr mutations Kanishka T. Jayasundera, Sarwar Zahid, Kari Branham, Naheed Khan, Mohammad Othman, Anand Swaroop, Paul Sieving, John Heckenlively 17. Mutations in CRB1 and ABCA4 genes cause Leber Congenital Amaurosis and Stargardt disease in a Swedish family Frida Jonsson, Marie Burstedt, Ola Sandgren, Irina Golovleva 18. Dehydrodolichol Diphosphate Synthase (DHDDS) Mutation K42E Causes Recessive Retinitis Pigmentosa Byron L. Lam, Stephen L. Züchner, Julia Dallman, Rong Wen, Jeffrey M. Vance, Margaret A. Peričak-‐Vance 19. Mutation Screening of Multiple Genes in Japanese Patients with Leber’s congenital amaurosis and early onset retinitis pigmentosa. Akira Murakami, Takurou Fujimaki, Ai Miyazaki, Eisuke Arai, Keiko Fujiki All Week 17 RD2012 Poster Presentations 20. NMNAT1 Mutations Cause Leber Congenital Amaurosis at the LCA9 Locus Eric Pierce, Marni J. Falk, Eiko Nakamaru-‐Ogiso, Chitra Kannabrian, Zoe Fonseca-‐Kelly, Christina Chakarova, Isabelle Audo, Naushin Waseem, Christina Zeitz, Magdalena Staniszewska, Rachna Shukla, Lakshmi Palavalli, Saddek Mohand-‐Said, Subhadra Jalali, Andrew R. Webster, Anthony T. Moore, Juan C. Perin, Emily Place, Julian Ostrovsky, Mark Consugar, José-‐Alain Sahel, Shomi Bhattacharya, Eliot L. Berson, Qin Liu, Xiaowu Gai, Qi Zhang 21. IROme, a new high-‐throughput molecular tool for the diagnosis of inherited retinal dystrophies Daniel Schorderet, Nathalie Voirol, Tatiana Favez, Maude Bernasconi, Leila Tiab, Pascal Escher 22. Comparative Genetic Association Study of HTRA1 and CFH in Wet Age-‐related Macular Degeneration in Chinese and Caucasian Populations Ming Zhang, Zhiguang Su, Ling Zhao, Li Zhang, Shuyuan Lv, Yuliang Feng, Guiqun Cao, Fang Lu, Peter Shaw, Kang Zhang 23. Pretreatment by NSAID, Sulindac Protects RPE Cells Against Oxidative Stress Janet C. Blanks, Arunodoy Sur, Diane Baronas-‐Lowell, Howard M. Prentice, Herbert Weissbach 24. Systematic Mapping of RPE Phagocytosis Pathways Nora Blanca Caberoy, Yixiong Zhou, Gabriela Alvarado, Wei Li 25. Morphological analysis of the vitelliform lesion, photoreceptors, and retinal pigment epithelium in Best vitelliform macular dystrophy using spectral domain optical coherence tomography Christine N. Kay, Michael D. Abramoff, Robert F. Mullins, Tyson R. Kinnick, Mina M. Chung, Elliott H. Sohn, Edwin M. Stone 26. L-‐ascorbic acid May Protect Hydrogen Peroxide Damaged hRPE Cells By Stimulating Intracellular Erythropoietin Piyush C. Kothary, Monte A. Del Monte 27. Modulation of Laser-‐Induced Choroidal Neovascularization by Differentiated Macrophages from Patients with Age Related Macular Degeneration Shira H. Levi, Tareq Jaouni, , Michelle Grunin, Tal B. Cohen Itay Chowers 28. Age-‐dependent defects in the lysosomes of RPE cells are similar to those of ABCA4-‐/-‐ mice Claire H. Mitchell, Alan M. Laties 29. Predictive value of the RPE sheet in mouse and human retina disease. John M. Nickerson, X. Qi, Micah A. Chrenek, Christopher Gardner, Qing Zhang, Hans Grossniklaus, Yi Jiang 30. Deciphering the effects of the bisretinoid A2E on mitogen-‐activated protein kinase in the retinal pigmented epithelium Linda Wicht, Martine Emery, Daniel Schorderet, Raphael Roduit 31. Melanolipofuscin of the aged RPE is a greater source of (photo)oxidative stress than lipofuscin or melanosomes Malgorzata B. Rozanowska, Ruth Edge, Floriana Tuna, Daniel Sells, Stephen Sproules 32. Localized Exposure of Phosphatidylserine by Rod Outer Segment Tips in Wild-‐type, but not β5-‐/-‐ or MFG-‐ E8-‐/-‐ Mouse Retina Linda Ruggiero, Mark P. Connor, Silvia C. Finnemann 18 All Week RPE and Neovascularization RD2012 Poster Presentations 33. Impairment of ubiquitin function in RPE causes AMD-‐like lesions in mice Qingning Bian, Benchun Miao, Allen Taylor, Donald Smith, Janis Lem, Paulo Pereira, Fu Shang 34. PEDF Stabilizes Mitochondrial Function in RPE cells during Oxidative Stress Joyce Tombran-‐Tink, Yanling Liu, Anzor Gvritishvili Therapeutic approaches Intra-‐scleral transplantation of collagen sheet with cultured brain-‐derived neurotrophic factor expressing cells partially rescued the retina from the damage of acute high intraocular pressure. Toshiaki Abe, Yumi Ishikawa, Hideyuki Onami, Yuki Katsukura, Nobuhiro Nagai 36. Nanoceria treatment results in sustained therapeutic effects in Vldlr-‐/-‐ mice Xue Cai, Lijuan Chen, Sudipta Seal, James F. McGinnis 37. A novel photoreceptor-‐permissive variant of AAV2 with a 7-‐peptide insertion leads to functional rescue in the mouse model of X-‐linked retinoschisis Timothy Day, Leah Byrne, Deniz Dalkara, John Flannery, David Schaffer 38. AAV8-‐mediated gene therapy leads to long-‐term photoreceptor survival in the rd6 mouse model of retinal degeneration Astra Dinculescu, Qiuhong Li, Wen-‐Tao Deng, Seok-‐Hong Min, William W. Hauswirth 39. Cell type specific promoters for use in gene therapy of retinal degenerative diseases Frank M. Dyka, Sanford L. Boye, Shannon E. Boye, Elizabeth M. Simpson, Charles N. de Leeuw, Andras M. Komaromy, ConnieY. Yeh, William W. Hauswirth 40. Pathophysilogical Mechanisms and Treatment Strategies for Leber Congenital Amaurosis Yingbin Fu, Tao Zhang, Ning Zhang, Wolfgang Baehr 41. Rescue of a Stargardt’s model via nanoparticle-‐mediated ABCA4 delivery Zongchao Han, Rasha Makkia, Shannon M. Conley, Mark J. Cooper, Muna I. Naash 42. Usher syndrome type1B gene therapy using two adeno-‐associated viral strategies for delivery of the large MYO7A cDNA Vanda S. Lopes, Shannon E. Boye, Sanford Boye, Carrie Louie, Frank Dyka, David S. Williams 43. Gene Replacement Therapy Restores Vision and Delays Degeneration in the CNGB1-‐/-‐ Mouse Model of Retinitis Pigmentosa Susanne Koch, Vithiyanjali Sothilingam, Marina Garcia Garrido, Naoyuki Tanimoto, Fred Koch, Elvir Becirovic, Mathias W. Seeliger, Martin Biel, Regine Mühlfriedel, Michalakis Stylianos 44. Comparative analysis supporting DNA nanoparticles as an attractive complement to AAVs for ocular gene delivery Muna I. Naash, Shannon M. Conley, Rasha Makkia, Junjing Guo, Mark J. Cooper, Zongchao Han 45. Therapy strategies for Usher syndrome type 1C in the retina Kerstin Nagel-‐Wolfrum, Tobias Goldmann, Nora Overlack, Mirjana Becker, Melissa Faust, Jan M. Vetter, Bernd Wissinger, Uwe Wolfrum All Week 35. 19 RD2012 Poster Presentations 46. Efficacy of AAV2/5 co-‐delivery in the mouse retina Arpad Palfi, Naomi Chadderton, Alfonso Blanco Fernandez, Peter Humphries, Paul F. Kenna, G. Jane Farrar 47. Systemic CR2-‐targeted Complement Inhibitor CD59 Demonstrates Protective Effect against Mouse Laser-‐ induced Choroidal Neovascularization Gloriane Schnabolk, Stephen Tomlinson, Bärbel Rohrer 48. Strategies and progress toward developing gene-‐placement therapy for RDH12 mutations Debra Thompson, Lin Jia, Jingyu Yao, Kecia L. Feathers, David N. Zacks, Selina Azam, Alexander J. Smith, Robin R. Ali 49. Long Term safety and efficacy of human induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa Stephen Tsang 50. Chitosan microparticles for the delivery of therapeutic agents to the retina. Sarah Wassmer, Mehrdad Rafat, Adam Baker, Wai Gin Fong, Catherine Tsilfidis 51. Assessment of different gene therapy strategies for preventing blindness in Usher syndrome type1B Vanda S. Lopes, Carrie M. Louie, Agrani Rump, David S. Williams 52. What Blind Retinitis Pigmentosa Patients Can See when Using the New Subretinal Wireless Implant Alpha-‐ IMS Eberhart Zrenner, Karl-‐Ulrich Bartz-‐Schmidt, Angelika Braun, Anna Bruckmann, Florian Gekeler, Udo Greppmaier, Stephanie Hipp, Gernot Hoertdoerfer, Christoph Kernstock, Akos Kusnyerik, Hans Sachs, Katarina Stingl 53. Neuroprotectin D1 modulates protein misfolding-‐induced proteotoxic stress in retinal pigment epithelial cells. Nicolas Bazan 54. Short-‐term psychosocial stress protects against light-‐induced damage of photoreceptors via a corticosterone-‐mediated activation of the akt pathway. Tembei Kieran Forkwa, Ernst Tamm, Andreas Ohlmann, Stefan Reber 55. Mapping the Putative Neurotrophic Receptor Binding Domain on Pigment Epithelium-‐derived Factor Jason D. Kenealey, David Hoover, S. Patricia Becerra 56. S-‐Nitrosylation of histone deacetylase 2 promotes optic nerve regeneration by retinoic acid receptor beta expression Yoshiki Koriyama, Kenzo Chiba, Matsumi Yamazaki, Kayo Sugitani, Satoru Kato 57. Cellular interplay in channeling signals for retinal neuron survival in diabetes Yun-‐Zheng Le, Ke Shi, Shuhua Fu, Shuqian Dong, John D. Ash, Meili Zhu 58. Glutathione S-‐Transferase Pi Isoform (GSTP1) Expression in Murine Retina Increases with Developmental Maturity Wen-‐Hsiang Lee, Pratibha M. Joshi, Rong Wen 20 All Week Protection RD2012 Poster Presentations 59. Norrin mediates neuroprotective effects on retinal ganglion cells via the induction of Lif Stephanie Leopold, Roswitha Seitz, Ernst R. Tamm, Andreas Ohlmann 60. MANF protects rod and cone photoreceptors from degeneration in transgenic rats carrying the S334ter rhodopsin mutation Yiwen Li, Lingyu Luo, Deqiang Huang, Xin Xia, Zhengying Wang, Pingping Chen, Byron L. Lam, Rong Wen 61. Targeting cell death pathways activated in murine models of retinitis pigmentosa Antonella Comitato, Valeria Marigo 62. Neuroprotective effects of electrical stimulation on retinal degeneration Moon K. Kim, Joel G. Thomas, Alice M. Adkins, Tracy Obertone, Moe H. Aung, Vincent T. Ciavatta, John R. Hetling, Machelle T. Pardue 63. 670nm Red Light: Protection Against Retinopathy of Prematurity Riccardo Natoli, Krisztina Valter, Marconi Barbosa, Jane Dahlstrom, Jan Provis, Alison Kent 64. HDAC inhibition restores visual function in blind dying on edge (dye) mutants Lisa Shine, Theresa Heffernan, Sudhakar Deeti, Beata Sapetto-‐Rebow, Alison Reynolds, Yolanda Alvarez, Breandan Kennedy 65. Optineurin is Required for Neuronal Survival in the Retina Christiane Sippl, A. K. Bosserhoff, D. Fischer, Ernst R. Tamm 66. Progesterone and glucocorticoid-‐dependent mechanisms in photoreceptor protection Angela M. Suburo, Marisa A. Cubilla, Melisa D. Marquioni, Vicente Bermudez 67. Reciprocal changes of factor XIII and retinal transglutaminase expressions in the fish retina during optic nerve regeneration Kayo Sugitani, Kazuhiro Ogai, Satoru Kato 68. Measuring the Neuroprotective Effects of Nanoceria in the P23H-‐1 Rats Lily L. Wong, Quentin N. Pye, Lijuan Chen, Sudipta Seal, James F. McGinnis 69. Norrin Mediates Its Protective Properties Against Oxygen-‐Induced Retinal Damage By Induction Of IGF-‐1 Expression Ludwig F. Zeilbeck, Berna Sentürk, Thomas Langmann, Ernst R. Tamm, Andreas Ohlmann 70. Deletion of Unc119 partially rescues defect in transport of rhodopsin kinase to cone photoreceptor outer segments in Pde6d knockout mice Houbin Zhang, Jeanne M Frederick, Wolfgang Baehr 71. Müller cell integrity is essential to retinal neurons in diabetes Meili Zhu, Shuhua Fu, Shuqian Dong, Yun-‐Zheng Le All Week 21 RD2012 Poster Presentations 72. Characterization of connexins in photoreceptor cell death propagation in mouse models of Retinitis Pigmentosa Daniel Adesse, Emilia Araujo Zin, William W. Hauswirth, David C. Spray, Rafael Linden, Hilda Petrs-‐Silva 73. Expression of Mutant ELOVL4 In Absence Of Retinal VLC-‐PUFAs Leads To Photoreceptor Dysfunction Martin-‐Paul G. Agbaga, Blake Hopiavuori, Mandal Md Nawajes, Richard Steven Brush, Lea Marchette, Michael H. Elliott, Radha Ayyagari, Robert E. Anderson 74. Dysregulation of the outer blood-‐retinal barrier in hyperoxic mice is regulated by 670nm light pretreatment Rizalyn Albarracin, Riccardo Natoli, Krisztina Valter, Jan Provis 75. Inhibition of EGF signaling protects the diabetic retina from insulin-‐induced vascular leakage Masahiko Sugimoto, Alecia Cutler, Scot Moss, Sudha Iyengar, Ron Klein, Judah Folkman, Bela Anand-‐Apte 76. Cell type-‐specific epigenetic signatures accompany late stages of mouse retina development in vivo Colin J. Barnstable, Evgenya Popova, Samuel Shao-‐Min Zhang 77. Retinal developmental defects in the good effort mutant zebrafish are correlated with elevated cell death Travis J. Bailey, Kristin M. Ackerman, Thomas S. Vihtelic, Aaron D. DenDekker, Gregory B. Willer, Corey Watson, Ronald G. Gregg, David R. Hyde 78. Conditional TGF beta deficiency enhances apoptosis of retinal neurons during development and influences retinal NGF expression Barbara M. Braunger, Stefan M. Pielmeier, Cora Demmer, Victoria Landstorfer, Daniela Kawall, Herbert Jägle, Ernst R. Tamm 79. Targeting of cone lamella/plasma membrane proteins to distinct membrane domains is independent of outer segment structure Shannon M. Conley, Reem M. Alomer, Muna I. Naash 80. Investigating the role of α-‐crystallins in photoreceptor maintenance and survival Séverine Hamann, Sylviane Métrailler, Daniel Schorderet, Sandra Cottet 81. Unlocking the Divergent Functions of Visual Arrestins: Cone Arrestin 4 Knockout Phenotypes Reveal Abnormal Photopic ERG and Defective Contrast Sensitivity Responses Cheryl M. Craft, Bruce M. Brown, Lawrence L. Rife, Moon K. Kim, Moe H. Aung, Machelle T. Pardue 82. Functional and Biochemical Defects of Cone CNG Channel in the Absence of the Modulatory Subunit CNGB3 Xi-‐Qin Ding, Jianhua Xu, Arjun Thapa, Lynsie Morris, Hongwei Ma, Jin-‐Shan Wang, Vladimir Kefalov 83. Identification of Functional Domains of Cep290 Theodore G. Drivas, Adam Wojno, Laura Bryant, Jean Bennett 84. Development of Retinal Degeneration, Insulin Resistance and Blindness in a Mouse Model of Chronic Posterior Uveitis Charles E. Egwuagu, Cheng-‐Rong Yu, Chi-‐Chao Chan, Hyun-‐Mee Oh 85. Retinal Degeneration in a Rat Model of Smith-‐Lemli-‐Opitz Syndrome is Caspase-‐Independent, and Involves Cathepsin D Upregulation Matthew D. Behringer, Bruce A. Pfeffer, Steven J. Fliesler 22 All Week Mechanisms of Degeneration (incl Signaling, Cytokines) 86. High Throughput Screening Strategies for Photoreceptor Development and Survival John A Fuller, James Inglese, Donald J Zack 87. Analysis and characterization of microglia/macrophage populations in canine models of early-‐onset retinal degeneration Sem Genini, William A. Beltran, Veronika M. Stein, Gustavo D. Aguirre 88. Interaction of Tulp1 and the Microtubule-‐associated Proteins in the Murine Retina Gregory H Grossman, Craig Beight, Lindsey A Ebke, Stephanie A Hagstrom 89. Global identification of photoreceptor genes co-‐regulated by NRL and CRX, and implications for retinal degenerative diseases Hong Hao, Douglas S Kim, Bernward Klocke, Kory R Johnson, Kairong Cui, Norimoto Gotoh, Yang Fann, Martin Seifert, Keji Zhao, Anand Swaroop 90. Studies on Rho-‐/-‐C5aR-‐/-‐ and Rho-‐/-‐CFH-‐/-‐ mice show a protective role for C5a-‐ and IL-‐1 receptors in retinal degeneration. Marian M. Humphries, Matthew Campbell, Paul F. Kenna, Anna-‐Sophia Kiang, Peter Humphries 91. The CRX target-‐gene Samd7 is a retina-‐specific transcriptional repressor Marcus Karlstetter, Julia Hlawatsch, Yana Walczak, Michael Plank, Julia Boeck, Thomas Langmann 92. Insights into the Molecular Pathology of Retinitis Pigmentosa with Choroidal Involvement Caused by the Dominant Mutation RPE65 D477G Anna-‐Sophia Kiang, Marian M. Humphries, Paul F. Kenna, Matthew Campbell, Peter Humphries 93. Conditional Smad7 deficiency causes increased proliferation in the central retina of newborn mice Martina Klupp, Barbara Braunger, Rudolf Fuchshofer, Ludwig Aigner, Ernst R. Tamm 94. The Olfactomedin Proteins Pancortin and Myocilin Modulate Apoptosis of Retinal Neurons after Damage Marcus A. Koch, Bernd Rosenhammer, Barbara M. Braunger, Walter Paper, Ernst R. Tamm 95. Mechanism behind cone degeneration and dysfunction in a mouse model for Leber congenital amaurosis Saravanan Kolandaivelu, Visvanathan Ramamurthy 96. The Involvement of BiP and CHOP in Environmental and Genetic Models of Retinal Degeneration Heike Kroeger, Carissa Messah, Kelly Ahern, Jason Gee, Victory Joseph, Michael T. Matthes, Marina S. Gorbatyuk, Matthew M. LaVail, Jonathan H. Lin 97. The role of von Hippel-‐Lindau tumor suppressor (VHL)-‐hypoxia-‐inducible factor (HIF) system in age-‐related macular degeneration Toshihide Kurihara, Peter D. Westenskow, Stephen Bravo, Edith Aguilar, Martin Friedlander 98. Exploring Stargardt3 mutant ELOVL4 enzymatic activity: putative mechanism in the pathogenesis of dominant Stargardt macular dystrophy Sreemathi Logan, Martin-‐Paul G. Agbaga, Michael D. Chan, Richard S. Brush, Robert E. Anderson 99. Aryl hyrdrocarbon Receptor Deficiency Affects Retinal Function and Morphology Goldis Malek, Peng Hu, Amanda Bednar, Peter Saloupis 100. Mechanisms of light-‐induced retinal degeneration associated with glycosylation-‐deficient rhodopsins Orson L. Moritz, Beatrice M. Tam 101. Screening for retinal mutants in the Translational Vision Research Models (TVRM) chemical mutagenesis program at The Jackson Laboratory Patsy M. Nishina, Lan Ying Shi, Wanda Hicks, Jieping Wang, Lisa Stone, Bo Chang, Juergen N. Naggert 102. Intrinsic upregulation of Yamanaka factors in the adult zebrafish retina after optic nerve injury Kazuhiro Ogai, , Maki Nishitani, Ayaka Kuwana, Keiko Homma, Kazuhiro Mawatari, Satoru Kato 23 All Week RD2012 Poster Presentations RD2012 Poster Presentations Interleukin-‐18 (IL-‐18) as a regulator of choroidal neovascularisation; Molecular pathways and mechanism of action Ema Ozaki, Matthew Campbell, Sarah L. Doyle, Robert G. Salomon, Andres Mori, Paul F. Kenna, Anna-‐Sophia Kiang, Marian M. Humphries, Ed C. Lavelle, Luke A.J. O'Neill, Joe G. Hollyfield, Peter Humphries 104. How long does a photoreceptor cell take to die? Insights from in vitro, in vivo, and mathematical models for Retinitis Pigmentosa. Ayse Sahaboglu, Olivier Paquet-‐Durand, Bernd Hitzmann, Marius Ueffing, François Paquet-‐Durand 105. Manipulating the Nrf2 anti-‐oxidant system to delineate the mechanisms of AMD onset Penny Goodman, Wendi Simpson, Kendra Plafker, William W. Hauswirth, Scott Plafker 106. Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model Nathalie Produit-‐Zengaffinen, Constantin J. Pournaras, Daniel F. Schorderet 107. A P25L Rpe65 knock-‐in mouse replicates key features of human Rpe65 hypomorphic missense mutation phenotype Yan Li, Shirley Yu, Eugenia Poliakov, Haohua Qian, Lijin Dong, Mercedes Campos, Robert N. Fariss, T. Michael Redmond 108. Characterization of the retinal phenotype in PARG KO animals Ayse Sahaboglu, Naoyuki Tanimoto, Marina Garcia Garrido, Mathias W. Seeliger, Eberhart Zrenner, Marius Ueffing, Francois Paquet-‐Durand 109. Cell death mechanisms in an all-‐cone retina: characterization of two inherited mouse models for retinal degeneration Marijana Samardzija, Isabelle Meneau, Sarah C. Willcox, Severin R. Heynen, Christian Grimm 110. Functional characterisation of the human RPGR proximal promoter Xinhua Shu, Julie R. Simpson, Alan Hart, Philippe Gautier, Emma Murdoch, Brian Tulloch, Alan F. Wright 111. Fundus Autofluorescence Findings in a Mouse Model of Retinal Detachment Janet R. Sparrow, Roberta Secondi 112. Phenotypic Characteristics and Invivo Cone Photoreceptor Mosaic in KCNV2-‐Related “Cone Dystrophy with Supernormal Rod Electroretinogram Ajoy Vincent, Tom Wright, Yaiza Garcia-‐Sanchez, Marsha L. Kisilak, Daniel Ferguson, Melanie C. Campbell, Carol A. Westall, Elise Héon 113. Electroretinography in aging Cln3Δex7/8 KI mutant mice Cornelia Volz, Myriam Mirza, Thomas Langmann, Herbert Jägle 114. Knock-‐down DHDDS expression induces photoreceptor degeneration in zebrafish Rong Wen, Julia Dallman, Yiwen Li, Stephan L. Züchner, Jeffery M. Vance, Margaret Peričak-‐Vance, Byron L. Lam 115. The C-‐terminal conserved domain of the retinitis pigmentosa 28 protein FAM161A is involved in dimerization and microtubule association Frank Zach, Heidi Stöhr 116. Dominant negative effect of mutant ELOVL4 on synthesis of very long chain polyunsaturated fatty acid Meixia Zhang, Richard Harkewicz, Ming Zhang, Hongjun Du, Peter Shaw, Edward Dennis, Kang Zhang All Week 103. 24 Directory of Participants A Toshiaki Abe Division of Clinical Cell Therapy Tohoku University Graduate School of Medicine 1-‐1 Seiryo-‐Machi, Aoba-‐ku Sendai, Miyagi, 980-‐8574, Japan Phone: 81-‐22-‐717-‐8234 eMail: [email protected] Daniel Adesse UFRJ Department of Neurobiology Avenida Carlos Chagas Filho 373 Rio de Janeiro, RJ 21941-‐902, Brazil Phone: 5521-‐2562-‐6562 eMail: [email protected] Martin-‐Paul Agbaga Ophthalmology Univ of Oklahoma, Health Sciences Center Dean A. McGee Institute 608 Stanton L. Young Blvd. Oklahoma City, OK 73104, USA Phone: 405-‐313-‐4539 eMail: martin-‐paul-‐[email protected] Cavit Agca Lab for Retinal Cell Biology Dept Ophthalmology University of Zurich Wagistrasse 14 Schlieren 8952, Switzerland Phone: 41793677915 eMail: [email protected] Gustavo Aguirre University of Pennsylvania 3900 Delancey Street, Room 2050 Philadelphia, PA 19104, USA Phone: 215-‐898-‐4667 eMail: [email protected] Rizalyn S. Albarracin John Curtin School of Medical Research The Australian National University Garran Road Canberra, ACT 0200, Australia Phone: +61 424 722 449 eMail: [email protected] Bela Anand-‐Apte Cole Eye Institute, I3-‐161 Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195, USA Phone: 216-‐445-‐9739 eMail: [email protected] Robert E. Anderson Ophthalmology Univ of Oklahoma, Health Sciences Center Dean A. McGee Institute 608 Stanton L. Young Blvd. Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8250 eMail: robert-‐[email protected] John D. Ash Ophthalmology University of Florida 1600 SW Archer Rd. Gainesville, FL 32610, USA Phone: 352-‐273-‐8328 eMail: [email protected] Alexander Aslanidis Institute of Human Genetics University of Regensburg Franz-‐Josef-‐Strauß Allee 11 Regensburg, D-‐93053, Germany Phone: 0941/9445425 eMail: [email protected] B Franz Badura Pro Retina Foundation Mühlgasse 1a Amberg D-‐92224, Germany Phone: 49-‐9621-‐602-‐551 eMail: franz.badura@t-‐online.de Travis Bailey Department of Biological Sciences University of Notre Dame 027B Galvin Life Sciences Building Notre Dame, IN 46556, USA Phone: 574-‐631-‐2895 eMail: [email protected] 25 Directory of Participants Colin J. Barnstable Dept of Neural and Behavioral Sciences Penn State University, College of Medicine 500 University Drive Hershey, PA 17033, USA Phone: 717-‐531-‐3631 eMail: [email protected] Haydee E.P. Bazan Neuroscience Center Louisiana State University 2020 Gravier St. New Orleans, LA 70112, USA Phone: 504-‐599-‐0877 eMail: [email protected] Nicolas G Bazan Neuroscience Center of Excellence LSU Health Sciences Center 2020 Gravier Street New Orleans, LA 70112, USA Phone: 504-‐599-‐0831 eMail: [email protected] S. Patricia Becerra National Institutes of Health/NEI 6 Memorial Drive MSC0608 Bethesda, MD 20892-‐0706, USA Phone: 301-‐496-‐6514 eMail: [email protected] William A Beltran School of Veterinary Medicine University of Pennsylvania 3900 Delancey Street Philadelphia, PA 19104-‐6010, USA Phone: 1 215 898 4913 eMail: [email protected] Joseph C. Besharse Cell Bio Neurobio & Anatomy Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226, USA Phone: 414-‐955-‐8261 eMail: [email protected] Janet C. Blanks Center for Complex Systems & Brain Sciences Florida Atlantic University 777 Glades Road BS-‐12 Boca Raton, FL 33431-‐0991, USA Phone: 561-‐297-‐4310 eMail: [email protected] Jeffrey H. Boatright Department of Ophthalmology Emory University School of Medicine Emory Eye Center, Room B-‐5511 Atlanta, GA 30322, USA Phone: 404-‐778-‐4113 eMail: [email protected] Dean Bok Jules Stein Eye Institute University of California 100 Stein Plaza Los Angeles, CA 90095-‐7065, USA Phone: 310-‐825-‐6737 eMail: [email protected] Vera L. Bonilha The Cole Eye Institute Cleveland Clinic Foundation 9500 Euclid Avenue, i31 Cleveland, OH 44195, USA Phone: 216-‐445-‐7690 eMail: [email protected] Catherine Bowes Rickman Ophthalmology and Cell Biology Duke University Medical Center Box 3802 Durham, NC 27710, USA Phone: 919-‐668-‐0648 eMail: [email protected] Barbara M. Braunger Human Anatomy and embryology Universitatsstrasse 31 Regensburg, Bavaria 93053, Germany Phone: 0049-‐941-‐943-‐2880 eMail: [email protected]‐regensburg.de Eric L. Buckland Bioptigen, Inc. PO Box 13569 Durham, NC 27709, USA Phone: 919-‐314-‐5500 eMail: [email protected] Marie S. I. Burstedt Clinical Sciences/Ophthalmology Umea University Aspvagen 7 Umea 903 54, Sweden Phone: 0046-‐90133234 eMail: [email protected] 26 Directory of Participants Ronald A. Bush NEI/NIDCD National Eye Inst/NIH 50 South Drive, MSC 8021, Rm4339 Bethesda, MD 20892-‐8021, USA Phone: 301 451 9777 eMail: [email protected] Leah C. Byrne HWNI UC Berkeley 112 Barker Hall Berkeley, CA 94720, USA Phone: 510-‐642-‐0209 eMail: [email protected] C Nora B. Caberoy Bascom Palmer Eye Institute University of Miami Miller School of Medicine 1638 NW 10th Ave Miami, FL 33136, USA Phone: 702-‐481-‐9855 eMail: [email protected] Xue Cai Department of Ophthalmology University of Oklahoma Health Sciences Center 608 Stanton L. Young Blvd. Oklahoma City, OK 73104, USA Phone: 405-‐271-‐3692 eMail: [email protected] Vijayasarathy Camasamudram STRRMD NIH Bldg 50 Rm 4339, 50 South Drive Bethesda, MD 20892, USA Phone: 301-‐451-‐4621 eMail: [email protected] Matthew Campbell Ocular Genetics Unit Trinity College Dublin Dublin, Ireland Phone: 35318962484 eMail: [email protected] Christian Caprara Lab for Retinal Cell Biology Dept Ophthalmology University of Zurich Wagistrasse 14 Schlieren 8952, Switzerland Phone: +41445563005 eMail: [email protected] Chi-‐Chao Chan Immunopathology Section, Laboratory of Immunology National Eye Institute, National Institutes of Health 10 Center Drive, 10/10N103 Bethesda, MD 20892-‐1857, USA Phone: 1-‐301-‐496-‐0417 eMail: [email protected] Peter Charbel Issa Department of Ophthalmology University of Bonn Ernst-‐Abbe-‐Str. 2 Bonn 53127, Germany Phone: +49 (0)228 / 287-‐15505 eMail: [email protected]‐bonn.de Mei M. Chen Centre for Vision & Vascular Science Queen's University Belfast Belfast BT12 6BA, Northern Ireland Phone: 2890644615 eMail: [email protected] Chung-‐Jung Chiu LNVR JM USDA Human Nutrition Research Center on Aging at Tufts University 711 Washington St Boston, MA 02111, USA Phone: 617-‐556-‐3157 eMail: [email protected] Itay Chowers Ophthalmology Hadassah Medical Center PO Box 12000 Jerusalem 91120, Israel Phone: 97226778206 eMail: [email protected] 27 Directory of Participants Shannon M. Conley Dept. Cell Biology University of Oklahoma Health Sciences Center 940 Stanton L. Young Blvd., BMSB 781 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐2493 eMail: shannon-‐[email protected] Sandra Cottet Institute for Research in Ophthalmology (IRO) Gd Champsec 64 Sion 1950, Switzerland Phone: 41 27 205 79 06 eMail: [email protected] Scott W. Cousins Duke Center for Macular Diseases Duke Eye Center 2351 Erwin Road, DUMC 3802, Durham, NC 27710, USA Phone: 919-‐684-‐9010 eMail: [email protected] Cheryl M. Craft Department of Cell and Neurobiology Keck School of Medicine, University of Southern California 1355 San Pablo, CVRC 408 Los Angeles, CA 90033, USA Phone: 323-‐442-‐6692 eMail: [email protected] D Stephen P. Daiger Human Genetics Ctr/Sch of PH The University of Texas Health Science Ctr 1200 Herman Pressler Dr. Houston, TX 77030, USA Phone: 713-‐500-‐9829 eMail: [email protected] Shyamtanu Datta Institute of Human Genetics University of Regensburg Franz-‐Josef-‐Strauss Allee 11 Regensburg, Bavaria 93053, Germany Phone: 0941 944-‐5225 eMail: [email protected] Timothy P. Day Helen Wills Neuroscience Institute University of California, Berkeley 2032 Delaware St. Apt #1 Berkeley, CA 94709, USA Phone: 913-‐406-‐6710 eMail: [email protected] Robb U. de Longh Anatomy & Neuroscience University of Melbourne Grattan St Parkville, VIC 3010, Australia Phone: 61 3 83445788 eMail: [email protected] Enrique J. de la Rosa Cellular and Molecular Medicine CIB-‐CSIC Ramiro de Maeztu 9 Madrid E-‐28040, Spain Phone: 34/918373112 eMail: [email protected] Anneke I. den Hollander Ophthalmology Radboud University Nijmegen Medical Center Philips van Leydenlaan 15 Nijmegen 6525 EX, The Netherlands Phone: -‐3610395 eMail: [email protected] Astra Dinculescu Ophthalmology University of Florida 1600 SW Archer Rd Gainesville, FL 32610, USA Phone: 352-‐273-‐7548 eMail: [email protected] Xi-‐Qin Ding Dept. of Cell Biology University of Oklaoma health Sciences Center 940 Stanton L. Young Blvd., BMSB 553 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8001 x47966 eMail: xi-‐qin-‐[email protected] Jindong Ding Ophthalmology Duke University Medical Center PO BOX 3802 Durham, NC 27710, USA Phone: 9196680649 eMail: [email protected] 28 Directory of Participants Sarah L. Doyle Biochemistry and Immunology Trinity College Dublin Trinity Biomedical Sciences Institute Dublin 2, Ireland Phone: 353 1 8962449 eMail: [email protected] Theodore G. Drivas Cell and Molecular Biology UPenn 515 S. 22nd St Philadelphia, PA 19146, USA eMail: [email protected] Jacque L. Duncan Ophthalmology University of California, San Francisco 10 Koret Way, #K129 San Francisco, CA 94143-‐0730, USA Phone: 415-‐514-‐4241 eMail: [email protected] Maheswara R. Duvvari Ophthalmology Radboud University Nijmegen Medical Center Philips van Leydenlaan 15 Nijmegen 6525 EX, The Netherlands Phone: 31243668902 eMail: [email protected] Frank M. Dyka Ophthalmology University of Florida 1600 SW Archer Road Gainesville, FL 32608, USA Phone: 1-‐352-‐273-‐8784 eMail: [email protected] E Katayoon Ebrahimi Ophthalmology Johns Hopkins University 1550 Orleans street # 3001D3 Baltimore, MD 21231, USA Phone: 4105022939 eMail: [email protected] Charles E. Egwuagu National Institutes of Health Building 10, Room 10N109A Bethesda, MD 20892-‐1857, USA Phone: 301-‐496-‐0049 eMail: [email protected] Michael H. Elliott Ophthalmology Univ of Oklahoma Health Sciences Center 608 Stanton L. Young Blvd., DMEI 423 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8001 ext. 30024 eMail: michael-‐[email protected] Julian Esteve-‐Rudd Ophthalmology Jules Stein Eye Institute. University of California -‐ Los Angeles 200 Stein Plaza Los Angeles, CA 90095, USA Phone: +1 310 825 9546 eMail: [email protected] F Christina Fasser Retina International Ausstellungsstrasse 36 Zurich 8005, Switzerland Phone: 41 1444 1077 eMail: cfasser@e-‐link.ch Amani A. Fawzi Ophthalmology Northwestern University, Feinberg School of Medicine 645 N Michigan Ave Chicago, IL 60611, USA Phone: 312-‐908-‐8152 eMail: [email protected] Steven J. Fliesler Ophthalmology SUNY-‐Buffalo and VA Western NY Healthcare System 3495 Bailey Avenue-‐ Bldg 20 Buffalo, NY 14215, USA Phone: 716-‐862-‐6538 eMail: [email protected] 29 Directory of Participants Joseph Fogerty Cell Biology, Neurobiology, and Anatomy Medical College of Wisconsin 8701 Watertown Plank Rd Milwaukee, WI 53226, USA Phone: 414-‐456-‐8188 eMail: [email protected] Tembei Kieran Forkwa Institute of human anatomy and embryology University of Regensburg Universitätstr 31 Regensburg, Bavaria 93053, Germany Phone: 049 941 943 2844 eMail: tembei.forkwa-‐[email protected] Yingbin Fu Ophthalmology University of Utah 65 Mario Capecchi Dr Salt Lake City, UT 84132, USA Phone: 8012133436 eMail: [email protected] Rudolf Fuchshofer Institute of Human Anatomy University of Regensburg Universitaetstr. 31 Regensburg, Bavaria 93053, Germany Phone: 499419000000 eMail: [email protected] John Fuller Ophthalmology Johns Hopkins University 400 N Broadway Baltimore, MD 21287, USA Phone: 4109291021 eMail: [email protected] G Anne Galy Ophthalmology -‐ Preclinical Department Sanofi-‐Fovea 17 rue Moreau Paris 75012, France Phone: 33144164242 eMail: jameaux@fovea-‐pharma.com Frederic Geissmann CMCBI New Hunt’s House Guys Campus King’s College London Great Maze Pond London SE1 1U, UK Phone: +44 (0)207 848 6902 eMail: [email protected] Sem Genini School of Veterinary Medicine University of Pennsylvania 3900 Delancey St. Philadelphia, PA 19104, USA Phone: 215-‐573-‐9586 eMail: [email protected] Irina Golovleva Medical Biosciences, Medical and Clinical Genetics Umeå University, by 6M Umeå, SE-‐90185, Sweden Phone: 467856820 eMail: [email protected] Marina Gorbatyuk Cell Biology and Anatomy UNTHSC 3500 Camp Bowie Blvd. Fort Worth, Tx 76107, USA Phone: 817-‐735-‐2682 eMail: [email protected] Felix Grassmann Institute for Human Genetics University of Regensburg Franz-‐Josef-‐Strauß-‐Allee 11 Regensburg, Bavaria 93053, Germany Phone: 0049-‐941-‐944-‐5425 eMail: [email protected]‐r.de Jane S. Green Discipline of Genetics, Health Sciences Centre Memorial University of Newfoundland 300 Prince Philip Dr St John's, NL A1B3V6, Canada Phone: 1-‐709-‐777-‐6242 eMail: [email protected] 30 Directory of Participants Christian Grimm Lab for Retinal Cell Biology Dept Ophthalmology University of Zurich Wagistrasse 14 Schlieren 8952, Switzerland Phone: 0041 44 -‐556 3001 eMail: [email protected] Gregory Grossman Cleveland Clinic Cole Eye Institute i-‐31, 9500 Euclid Ave. Cleveland, OH 44195, USA Phone: 216-‐444-‐5663 eMail: [email protected] Michelle Grunin Ophthalmology Hebrew University -‐ Hadassah Ein Kerem Medical Center Hadassah Ein Kerem Medical Center Jerusalem 91120, Israel Phone: 972-‐2-‐677-‐8026 eMail: [email protected] H Stephanie A. Hagstrom Cole Eye Institute Cleveland Clinic 9500 Euclid Ave. Cleveland, OH 44195, USA Phone: 216-‐445-‐4133 eMail: [email protected] Zongchao Han Cell Biology University of Oklahoma Health Sciences Center 940 Stanton L. Young Blvd., BMSB 781 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐2402 eMail: Zongchao-‐[email protected] Hong Hao National Eye Institute National Institutes of Health 9000 Rockville Pike Bethesda, MD 20892, USA Phone: 301-‐451-‐6439 eMail: [email protected] Stefanie M. Hauck Research Unit Protein Science Helmholtz Zentrum München Ingolstädter Landstr. 1 Neuherberg D-‐85764, Germany Phone: -‐31873981 eMail: hauck@helmholtz-‐muenchen.de Weimin He Ophthalmology West China Hospital, Sichuan University Guoxuexiang 37 Chengdu, Sichuan Province 610041, China Phone: 18980601753 eMail: [email protected] V. Michael Holers Medicine/Immunology University of Colorado School of Medicine Box B115, 1775 Aurora Ct. Aurora, CO 80220, USA Phone: 303-‐724-‐7605 eMail: [email protected] Joe G. Hollyfield Cole Eye Institute-‐i31 Cleveland Clinic Lerner College of Medicine 9500 Euclid Avenue Cleveland, OH 44195, USA Phone: 216-‐445-‐3252 eMail: [email protected] Peter Humphries Department of Genetics Trinity College Dublin Lincoln Place Gate Dublin 2 D2, Ireland Phone: 3531-‐896-‐1547 eMail: [email protected] Marian M. Humphries Ocular Genetics Trinity College Lincoln Place Gate Dublin 2 D2, Ireland Phone: 353-‐1-‐6082484 eMail: [email protected] David R. Hyde Department of Biological Science University of Notre Dame 027 Galvin Life Sciences Building Notre Dame, IN 46556-‐0369, USA Phone: 574-‐631-‐8054 eMail: [email protected] 31 Directory of Participants I Michael Iuvone OPhthalmology Emory University School of Medicine 1365B Clifton Rd NE Atlanta, GA 30322, USA Phone: 1-‐404-‐727-‐5989 eMail: [email protected] Takeshi Iwata National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center 2-‐5-‐1 Higashigaoka Meguroku Tokyo 152-‐8902, Japan Phone: -‐34110948 eMail: [email protected] J Kanishka Thiran Jayasundera Kellogg Eye Center University of Michigan 1000 Wall Street An Arbor, MI 48105, USA eMail: [email protected] Frida M. K. Jonsson Medical Biosciences/Medical and Clinical Genetics Umea University Umea 90185, Sweden Phone: 46907851189 eMail: [email protected] K Michael Kalloniatis Centre For Eye Health C/-‐ UNSW, Barker Street, Gate 14 Kensington, NSW 2052, Australia Phone: 02 8115 0713 eMail: [email protected] Marcus Karlstetter Department of Experimental Immunology of the Eye University Hospital of Cologne Joseph-‐Stelzmann-‐Str. 9 Cologne 50931, Germany Phone: +49 (0)221 478-‐5738 eMail: marcus.karlstetter@uk-‐koeln.de Christine N. Kay Ophthalmology University of Florida 1600 SW Archer Road Gainesville, FL 32610, USA Phone: 3522738793 eMail: [email protected] Jason D. Kenealey Laboratory of Retinal Cell and Molecular Biology National Eye Institute 6 Center Drive room:134 Bethesda, MD 20892, USA Phone: 301-‐451-‐1969 eMail: [email protected] Breandan N. Kennedy UCD Conway Institute University College Dublin Dublin 4, Ireland Phone: 353-‐1-‐716-‐6740 eMail: [email protected] Anna-‐Sophia Kiang Ocular Genetics Unit Trinity College Dublin Dublin 2, Ireland Phone: 35316082486 eMail: [email protected] Sten Kjellstrom Ophthalmology Lund University Lund University Hospital Lund SE-‐22185, Sweden Phone: -‐46176791 eMail: [email protected] Kathryn E. Klump Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center 608 Stanton L. Young Blvd. Pavilion B, Room # L047 Oklahoma City, OK 73013, USA Phone: (405) 271-‐8001 x 30269 eMail: Kathryn-‐[email protected] 32 Directory of Participants Martina Klupp Department of Anatomy and Embryology University of Regensburg Universitätsstraße 31 Regensburg, Bavaria 93053, Germany eMail: [email protected] Hiroaki Kobayashi Ophthalmology Juntendo University 2-‐3-‐1 Teraodai Ayase-‐shi Kanagawa 252-‐1137, Japan Phone: -‐8597 eMail: [email protected] Marcus A. Koch Institute of Human Anatomy and Embryology University of Regensburg Universitätsstrasse 31 Regensburg, D-‐93053, Germany Phone: 9419432914 eMail: [email protected] Adarsha Koirala Cell Biology Univ of Oklahoma Health Sciences Center 940 S.L. Young Blvd., BMSB 781 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8001 x47967 eMail: adarsha-‐[email protected] Saravanan Kolandaivelu Ophthalmology West Virginia University One Stadium Drive Morgantown, WV 26506, USA Phone: 304-‐598-‐4893 eMail: [email protected] Yoshiki Koriyama Department of Neurobiology Kanazawa Univerity 13-‐1 Takara-‐machi Kanazawa, Ishikawa 920-‐8640, Japan Phone: 81762652451 eMail: [email protected]‐u.ac.jp Elod Kortvely Institute for Ophthalmic Research University of Tuebingen Rontgenweg 11 Tuebingen 72076, Germany Phone: +49 7071 29-‐80736 eMail: eloed.koertvely@uni-‐tuebingen.de Piyush Kothary Univ. of Michigan 1000 Wall Street Ann Arbor, MI 48105, USA Phone: 734 9369254 eMail: [email protected] Heike Kroeger Pathology University of California San Diego 9500 Gilman Drive La Jolla, CA 92093, USA Phone: 858-‐534-‐2744 eMail: [email protected] Tim U. Krohne Ophthalmology University of Bonn Ernst-‐Abbe-‐Str. 2 Bonn 53127, Germany Phone: -‐15505 eMail: krohne@uni-‐bonn.de Toshihide Kurihara Cell Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037, USA Phone: (858) 784-‐2930 eMail: [email protected] L Aparna Lakkaraju Ophthalmology & Visual Sciences University of Wisconsin-‐Madison 1300 University Ave Madison, WI 53706, USA Phone: 608-‐263-‐6176 eMail: [email protected] Byron L. Lam Bascom Palmer Eye Institute University of Miami Miller School of Medicine 900 NW 17 Street Miami, FL 33136, USA Phone: 305-‐326-‐6021 eMail: [email protected] 33 Directory of Participants Thomans Langmann Zentrum für Augenheilkunde Lehrstuhl für Experimentelle Immunologie des Auges Gebäude 35 (Anatomie), 3. OG Joseph-‐Stelzmann-‐Str. 9 Köln D-‐50931, Germany Phone: +49 (0)221 478-‐7324 eMail: thomas.langmann@uk-‐koeln.de Alan M. Laties Richards Bldg D-‐603 University of Pennsylvania Medical School 3700 Hamilton Walk Philadelphia, PA 19104-‐6075, USA Phone: 215-‐898-‐6508 eMail: [email protected] Matthew M. LaVail Beckman Vision Center UCSF School of Medicine 10 Kirkham Street San Francisco, CA 94143-‐0730, USA Phone: 415-‐476-‐4234 eMail: [email protected] Yun Zheng Le University of Oklahoma Health Sciences Center 941 Stanton L. Young Blvd., BSEB 302G Oklahoma City, OK 73104, USA Phone: 405-‐271-‐1087 eMail: Yun-‐[email protected] Wen-‐Hsiang Lee Ophthalmology Bascom Palmer Eye Institute, University of Miami Miller School of Medicine 900 NW 17th Street Miami, FL 33136, USA Phone: 305-‐326-‐6323 eMail: [email protected] Stephanie Leopold Human anatomy and embryology University of Regensburg Universitätsstr. 31 Regensburg, Bavaria 93053, Germany Phone: 0941 943 2914 eMail: [email protected] Shira Hagbi-‐Levi Department of Ophthalmology Hadassah Medical Center-‐The Hebrew University of Jerusalem Hadassah Medical Center PO Box 12000 Jerusalem 91120, Israel Phone: 02-‐6778026 eMail: [email protected] Yiwen Li Bascom Palmer Eye Institute University of Miami, Miller School of Medicine 506 McKnight Building Miami, FL 33136, USA Phone: 305-‐482-‐4874 eMail: [email protected] Jonathan H. Lin Department of Pathology University of California San Diego MC 0612 La Jolla, CA 92093-‐0612, USA Phone: 858-‐534-‐2743 eMail: [email protected] Sreemathi Logan Cell Biology University of Oklahoma HSC 608 Stanton L. Young Blvd. DMEI 419B Oklahoma City, OK 73104, USA Phone: 405 255 5339 eMail: [email protected] Vanda S. Lopes Centro of Ophthalmology Faculty of Medicine, University of Coimbra, Portugal Rua Julio Dinis No 21 1o No3 Coimbra 3030-‐319, Portugal Phone: 351293000000 eMail: [email protected] Ulrich F. O. Luhmann Genetics UCL Institute of Ophthalmology 11-‐43 Bath Street London EC1V 9EL, UK Phone: 442076000000 eMail: [email protected] 34 Directory of Participants M Goldis Malek Departments of Ophthalmology and Pathology Duke University Medical Center DUMC, Erwin Road, P.O. Box 3802 Durham, NC 27710, USA Phone: 919-‐684-‐0820 eMail: [email protected] Arvydas Maminishkis National Eye Institute 10 Center Drive, Bldg 10, Rm 10B04 Bethesda, MD 20892, USA Phone: 301-‐435-‐4902 eMail: [email protected] Nawajes A. Mandal Ophthalmology University of Oklahoma Health Sciences Center 608 S.L. Young Blvd., DMEI 409 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8001 x 30009 eMail: [email protected] Lea D. Marchette Cell Biology University of Oklahoma Health Sciences Center 608 Stanton L Young Blvd Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8001 ext. 30294 eMail: Lea-‐[email protected] Valeria Marigo Dept. of Biomedical Sciences University of Modena and Reggio Emilia via G. Campi, 287 Modena 41125, Italy Phone: 39 059 2055392 eMail: [email protected] Frédéric Mascarelli Centre de Recherche des Cordeliers INSERM 15 rue de l'école de Médecine Paris 75006, France Phone: 33 1 44 27 81 80 eMail: [email protected] James F. McGinnis Dean A. McGee Eye Institute University of Oklahoma Health Sciences Center 608 Stanton L. Young Blvd. Oklahoma City, OK 73104, USA Phone: 405-‐271-‐3695 eMail: james-‐[email protected] Paul G. McMenamin Department of Anatomy & Developmental Biology School of Biomedical Sciences Faculty of Medicine, Nursing and Health Sciences Monash University, Building 13C Wellington Rd, Clayton Victoria 3800, Australia Phone: (03) 99056219 eMail: [email protected] Michel Michaelides Genetics UCL Institute of Ophthalmology 11-‐43 Bath Street London EC1V 9EL, UK eMail: [email protected] Stylianos Michalakis Pharmacy Ludwig-‐Maximilians-‐Universität München Butenandstr. 7 München 81377, Deutschland Phone: 4989220000000 eMail: [email protected] Sheldon S. Miller National Eye Institute National Institutes of Health 31 Center Dr. Rm. 6A22 Bethesda, MD 20892, USA Phone: 301-‐451-‐6763 eMail: [email protected] Claire H. Mitchell Anatomy and Cell Biology University of Pennsylvania 440 Levy Bldg, 240 S 40th St Philadelphia, PA 19104, USA Phone: 215-‐990-‐6973 eMail: [email protected] 35 Directory of Participants Thomas W. Mittag Ophthalmology Mount Sinai School of Medicine 167 Woodland Drive Pleasantville, NY 10570, United States Phone: 914 769-‐3381 eMail: [email protected] Robert S. Molday Biochemistry and Molecular Biology University of British Columbia 2350 Health Sciences Mall Vancouver, BC V6T1Z3, Canada eMail: [email protected] Laurie L. Molday Biochemistry and Molecular Biology University of British Columbia 2350 Health Sciences Mall Vancouver, BC V6T1Z3, Canada eMail: [email protected] Orson L. Moritz Ophthalmology & Visual Sciences University of British Columbia 2550 Willow Street Vancouver, BC V5Z 3N9, Canada Phone: 6048754357 eMail: [email protected] Birgit Müller Human Anatomy and Embryology University of Regensburg Universitätsstrasse 31 Regensburg, Bavaria 93053, Germany Phone: 0941/943-‐2914 eMail: [email protected] Robert F. Mullins Ophthalmology and Visual Sciences University of Iowa 375 Newton Rd Iowa City, IA 52241, USA Phone: 319-‐335-‐8222 eMail: robert-‐[email protected] Akira Murakami Ophthalmology Juntendo University Graduate School of Medicine 2-‐1-‐1 Hongo Bunkyo-‐ku Tokyo 113-‐8421, Japan Phone: -‐9272 eMail: [email protected] N Muna I. Naash Department of Cell Biology University of Oklahoma Health Sciences Center 940 Stanton L. Young Blvd. Oklahoma City, OK 73104, USA Phone: 405-‐271-‐2388 eMail: muna-‐[email protected] Kerstin Nagel-‐Wolfrum Institute of Zoology, Cell and Matrix Biology Johannes Gutenberg University of Mainz Muellerweg 6 Mainz 55099, Germany Phone: +49 6131 -‐ 39-‐20131 eMail: nagelwol@uni-‐mainz.de Emeline F. Nandrot Department of Genetics Institut de la Vision 17 rue Moreau Paris Paris 75012, France Phone: 33 1 5346 2541 eMail: [email protected] Riccardo C. Natoli Medical School, John Curtin School Australian National University 131 Garran Road Canberra, ACT 0200, Australia Phone: +61 2 6125 8559 eMail: [email protected] Anh Thi Hong Nguyen Smurfit Institute of Genetics Trinity College Dublin Dublin 2, Ireland Phone: 35318962486 eMail: [email protected] John M. Nickerson Department of Ophthalmology Emory Eye Center Emory University B5602 1365B Clifton Road NE Atlanta, GA 30322, USA Phone: 404-‐778-‐4411 eMail: [email protected] 36 Directory of Participants Patsy M. Nishina Research The Jackson Laboratory 600 Main Street Bar Harbor, ME 04609, USA Phone: 207-‐288-‐6383 eMail: [email protected] O Kazuhiro Ogai Department of Molecular Neurobiology Kanazawa University 13-‐1, Takaramachi Kanazawa, Ishikawa 920-‐8640, Japan Phone: 81762652451 eMail: [email protected]‐u.ac.jp Andreas Ohlmann Dept. of Anatomy University of Regensburg Universitätsstr. 19 Regensburg, Bavaria 93053, Germany Phone: 0941-‐943-‐2880 eMail: [email protected] Ema Ozaki Ocular Genetics Trinity College Dublin Lincoln Place Gate Dublin 2, Ireland Phone: 353-‐1-‐8961140 eMail: [email protected] P Arpad Palfi Genetics Trinity College Dublin Lincoln Gate Dublin 2, Ireland Phone: 35318962484 eMail: [email protected] Francois D. Paquet-‐Durand Institute for Ophthalmic Research University of Tuebingen Roentgenweg 11 72076 Tuebingen 72076, Germany Phone: 4970710000000 eMail: francois.paquet-‐[email protected] Machelle T. Pardue Rehab Center of Excellence and Ophthalmology Atlanta VA Medical Center/Emory University School of Medicine Research Service (151), 1670 Clairmont Rd Decatur, GA 30033, USA Phone: 404-‐321-‐6111 x 7342 eMail: [email protected] Mark E. Pennesi Ophthalmology Oregon Health & Science University -‐ Casey Eye Institute 3375 SW Terwilliger Portland, OR 97239, USA Phone: 503-‐494-‐8386 eMail: [email protected] Eric A. Pierce Ophthalmology Massachusetts Eye and Ear Infirmary 243 Charles Street Boston, MA 02114, USA Phone: 617-‐573-‐6917 eMail: [email protected] Kendra S. Plafker Free Radical Biology and Aging Oklahoma Medical Research Foundation 825 N.E. 13th Street Oklahoma City, OK 73104, USA Phone: (405) 271-‐1735, (405) 271-‐1745 eMail: [email protected] Scott M. Plafker Free Radical Biology and Aging Oklahoma Medical Research Foundation 825 N.E. 13th Street Oklahoma City, OK 73104, USA Phone: (405) 271-‐1735, (405) 271-‐1745 eMail: [email protected] 37 Directory of Participants Nathalie Produit-‐Zengaffinen Institute for Research in Ophthalmologia Av. Grand-‐Champsec 64 Sion 1950, Switzerland Phone: +41 27 205 79 08 eMail: [email protected] Jan M. Provis ANU Medical School The Australian National University Peter Baume Bldg University Ave Canberra, ACT 2601, Australia Phone: 61 2 61254242 eMail: [email protected] R David Rabin Neural Stem Cell Insitute Albany Medical College One Discovery Drive Rensselaer, NY 12144, USA Phone: 518-‐694-‐8188 eMail: [email protected] Roxana A. Radu Jules Stein Eye Institute UCLA 100 Stein Plaza, Rm. BH-‐667/JSEI Los Angeles, CA 90095, USA Phone: 310-‐267-‐2664 eMail: [email protected] Mary E. Rayborn Cole Eye Institute (i31) The Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195, USA Phone: 216-‐444-‐5837 eMail: [email protected] T. Michael Redmond Building 6, Room 117A LRCMB, National Eye Institute 6 Center Dr. Bethesda, MD 20892-‐0608, USA Phone: 301-‐496-‐0439 eMail: [email protected] Charlotte E. Reme Ophthalmology University Zurich Zurichbergstrasse 127 Zurich 8044, Switzerland Phone: + 41 44 362 16 12 eMail: [email protected] Alison L. Reynolds UCD Conway Institute University College Dublin Belfield Dublin 4 Dublin4, Ireland Phone: 35317166740 eMail: [email protected] Raphael Roduit Institute for Research in Ophthalmology (IRO) Gd Champsec 64 Sion 1950, Switzerland Phone: 41 27 2057909 eMail: [email protected] Baerbel Rohrer Medical University of South Carolina 167 Ashley Ave, Rm 614 Charleston, SC 29425, USA Phone: 843-‐792-‐5086 eMail: [email protected] Stephen Rose Foundation Fighting Blindness 7168 Columbia Gateway Drive, Suite 100 Columbia, MD 21046, USA Phone: 410-‐423-‐0580 eMail: [email protected] Malgorzata Barbara Rozanowska Optometry and Vision Sciences Cardiff University Maindy Road Cardiff Wales CF24 4LU, UK Phone: 442921000000 eMail: [email protected] Linda Ruggiero Biology Fordham University 441 E. Fordham Road Bronx, NY 10458, USA Phone: 718-‐817-‐3627 eMail: [email protected] 38 Directory of Participants Elisabeth Rungger-‐Brandle University Eye Clinic Cell Biology Laboratory Saxerstrasse 8 Aarau 5000, Switzerland Phone: ++41 62 823 29 70 eMail: [email protected] Matt V. Rutar John Curtin School of Medical Research The Australian National University Building 131, Garran Road Acton, ACT 0200, Australia Phone: 61 0400220007 eMail: [email protected] S Ayse Sahaboglu Division of Experimental Ophthalmology Institute for Ophthalmic Research Röntgenweg 11 Tubingen 72070, Germany Phone: 1774654407 eMail: [email protected] Marijana Samardzija Lab for Retinal Cell Biology Dept Ophthalmology University of Zurich Wagistrasse 14 Schlieren 8952, Switzerland Phone: + 41 44 556 3007 eMail: [email protected] Gloriane Schnabolk Ophthalmology Medical University of South Carolina 171 Ashley Avenue Charleston, SC 29425, USA Phone: 843-‐792-‐2166 eMail: [email protected] Daniel Schorderet Ophthalmology Institut de Recherche Av Grandchampsec 64 Sion 1950, Switzerland Phone: 41272057900 Fax: 41272057901 eMail: [email protected] Mathias W. Seeliger Division of Ocular Neurodegeneration Institute for Ophthalmic Research Eberhard Karls University Schleichstr 4 / 3 Tuebingen D-‐72076, Germany Phone: 49 7071 2980718 eMail: [email protected] Roswitha Seitz Institute of Human Anatomy and Embryology University of Regensburg Universitätsstrasse 31 Regensburg 93053, Germany Phone: 499419000000 eMail: [email protected]‐regensburg.de Fu Shang Tufts University 711 Washington Street Boston, MA 2111, USA Phone: 617-‐556-‐3158 eMail: [email protected] Lisa Shine School of Biomolecular and Biomedical Science University College Dublin Belfield Dublin 4, Ireland Phone: 872235662 eMail: [email protected] Xinhua Shu Life Sciences Glasgow Caledonian University Glasgow G4 0BA, UK Phone: 0044 141 3318763 eMail: [email protected] Paul A. Sieving National Institutes of Health National Eye Instiute 31 Center Drive, MSC 2510 Bethesda, MD 20892, USA Phone: 3014962234 eMail: [email protected] Christiane Sippl Institute of Human Anatomy and Embryology University of Regensburg Universitätsstr. 31 Regensburg, Bavaria 93053, Germany eMail: [email protected] 39 Directory of Participants Janet R. Sparrow Ophthalmology Columbia University 630 W. 168th St. New York, NY 10032, USA Phone: 212-‐305-‐9944 eMail: [email protected] Dan Stamer Ophthalmology Duke University DUMC 3802 Durham, NC 27710, USA Phone: 919-‐684-‐3745 eMail: [email protected] Chloe M. Stanton MRC Human Genetics Unit University of Edinburgh MRC IGMM Western General Hospital, Crewe Road Edinburgh, Midlothian EH4 2XU, UK Phone: 0131 332 2471 eMail: [email protected] Olaf Strauss Experimental Ophthalmology University Medical Center Regensburg Franz-‐Josef-‐Strauss-‐Allee 11 Regensburg, Bavaria 93053, Germany Phone: 499419449228 eMail: strauss@eye-‐regensburg.de Preeti Subramanian National Eye Institute -‐ National Institutes of Health Bldg. 6 Rm. 131F Bethesda, MD 20892-‐0608, USA Phone: 301-‐451-‐1970 eMail: [email protected] Angela M. Suburo Cell and Molecular Medicine Facultad de Ciencias Biomedicas, Universidad Austral Peron 1500 Pilar Buenos Aires B1629AHJ, Argentina Phone: 542304000000 eMail: [email protected] Kayo Sugitani Division of Health Sciences Kanazawa University 5-‐11-‐80 Kodatsuno Kanazawa, Ishikawa 920-‐0942, Japan Phone: -‐2859 eMail: [email protected]‐u.ac.jp T Ernst Tamm Institute of Human Anatomy and Embryology University of Regensburg Universitatsstr. 31 Regensburg D-‐93053, Germany Phone: 49-‐941-‐943-‐2839 eMail: [email protected]‐regensburg.de Debra A. Thompson Ophthalmology and Visual Sciences University of Michigan, Kellogg Eye Center 1000 Wall Street Ann Arbor, MI 48105-‐0714, USA Phone: 734-‐936-‐9504 eMail: [email protected] Joyce Tombran-‐Tink Neural and Behavioral Sciences and Ophthalmology Penn State University College of Medicine 500 University Drive Hershey, PA 17033, USA Phone: 717-‐531-‐7475 eMail: [email protected] Gabriel H. Travis Jules Stein Eye Institution University of California Los Angeles School of Medicine 100 Stein Plaza, Bldg: JSEI Room: GH-‐667 Los Angeles, CA 90095, USA Phone: 310-‐267-‐2673 eMail: [email protected] Stephen Tsang Ophthalmology Columbia University 635 West 165th Street New York, NY 10032, USA Phone: 2123421189 eMail: [email protected] 40 Directory of Participants Catherine Tsilfidis Vision Science Program Ottawa Hospital Research Institute 501 Smyth Road Ottawa, Ontario K1H 8L6, Canada Phone: 613-‐737-‐8233 eMail: [email protected] V Krisztina Valter Medical School John Curtin School of Medical Research,The Australian National University Garran Road Canberra, ACT 2600, Australia Phone: +61 424 722 449 eMail: krisztina.valter-‐[email protected] Joseph Vance Bioptigen, Inc. PO Box 13569 Durham, NC 27709, USA Phone: 919-‐314-‐5500 eMail: [email protected] Ajoy Vincent Ophthalmology Hospital for Sick Children 555 University Avenue Toronto, Ontario M5G 1X8, Canada Phone: -‐5266 eMail: [email protected] Douglas Vollrath Dept. of Genetics Stanford University School of Medicine Stanford, CA 94305-‐5120, USA Phone: 650-‐723-‐3290 eMail: [email protected] Cornelia Volz Ophthalmology University Hospital Regensburg Franz-‐Josef-‐Strauss Allee 11 Regensburg, Bavaria 93053, Germany Phone: 4917620000000 eMail: [email protected] W Sarah J. Wassmer Cellular and Molecular Medicine Ottawa Hospital Research Institute 501 Smyth Road Ottawa, Ontario K1H 8L6, Canada Phone: 613-‐797-‐4373 ext. 73486 eMail: [email protected] Bernhard H.F. Weber Institute for Human Genetics University Regensburg Franz-‐Josef-‐Strauss-‐Allee 11 Regensburg, Bavaria 93053, Germany Phone: 49-‐941-‐9445400 eMail: [email protected]‐regensburg.de Rong Wen Bascom Palmer Eye Institute University of Miami, Miller School of Medicine 506 McKnight Building Miami, FL 33136, USA Phone: 305-‐482-‐4874 eMail: [email protected] Peter D. Westenskow Cell Biology The Scripps Research Insitute 10550 North Torrey Pines Rd La Jolla, CA 92014, USA Phone: 858-‐784-‐2930 eMail: [email protected] Holly J. Whiteside Ophthalmology Univ of Oklahoma Health Sciences Center 608 Stanton L. Young Blvd., DMEI PB420 Oklahoma City, OK 73104, USA Phone: 405-‐271-‐8252 eMail: Holly-‐[email protected] David S. Williams Jules Stein Eye Institute UCLA School of Medicine 100 Stein Plaza Los Angeles, CA 90095, USA Phone: 858-‐229-‐6234 eMail: [email protected] 41 Directory of Participants Uwe Wolfrum Institute of Zoology, Cell and Matrix Biology Johannes Gutenberg University of Mainz Mullerweg 6 Mainz D-‐55099, Germany Phone: 49-‐6131-‐3925148 eMail: wolfrum@uni-‐mainz.de Lily L. Wong Ophthalmology OUHSC 608 Stanton L Young Blvd Oklahoma City, OK 73104, USA Phone: 4052713371 eMail: lily-‐[email protected] Wai T. Wong National Eye Institute, NIH 7502 Westlake Terrace Bethesda, MD 20817, USA Phone: 301-‐496-‐1758 Fax: 301-‐496-‐1759 eMail: [email protected] Alex S. Woodell Neurosciences Medical University of South Carolina 96 Jonathan Lucas Street, CSB 301 Charleston, SC 29425-‐6160, USA Phone: 843.792.2166 eMail: [email protected] Y Xian-‐Jie Yang Jules Stein Eye Institute University of California School of Medicine 100 Stein Plaza Los Angeles, CA 90095, USA Phone: 310-‐825-‐7020 eMail: [email protected] Z Frank Zach Institute of Human Genetics University of Regensburg Franz-‐Josef-‐Strauß-‐Allee 11 Regensburg, Bavaria 93053, Germany Phone: 0941-‐944-‐5449 eMail: [email protected]‐regensburg.de Don Zack Ophthalmology Johns Hopkins Smith 3029, 400 N Broadway Baltimore, MD 21287, USA Phone: 410 502-‐5230 eMail: [email protected] Ludwig F. Zeilbeck Department of Human Anatomy and Embryology University of Regensburg Universitätsstr. 31 Regensburg, Bavaria 93053, Germany Phone: 9419432914 eMail: [email protected] Houbin Zhang Ophthalmology University of Utah Rm S6871, 65 N Capecchi Dr Salt Lake City, UT 84132, USA Phone: 801-‐585-‐7934 eMail: [email protected] Meixia Zhang Department of Ophthalmology West China Hospital, Sichuan University 37 Guoxuexiang Chengdu, Sichuan 610041, China Phone: 862885000000 eMail: [email protected] Ming Zhang Ophthalmology Sichuan University No. 37, Guoxuexiang Chengdu, Sichuan 610041, China Phone: 8618980000000 eMail: [email protected] 42 Directory of Participants Mei Li Zhu Medicine OUHSC 941 Stanton L. Young Blvd, BSEB 302G Oklahoma City, OK 73104, USA Phone: 405-‐271-‐1087 eMail: Meili-‐[email protected] Patricia Zilliox Foundation Fighting Blindness 6 Heathrow Ct. Arlington, TX 76016, USA Phone: 817-‐466-‐3393 eMail: [email protected] Eberhart Zrenner Dept. for Ophthalmology University Eye Hospital, Dept II Schleichstr. 12-‐16 Tubingen D-‐72076, Germany Phone: 49-‐7071-‐2984786 eMail: ezrenner@uni-‐tuebingen.de 43 RD2012 Sponsors We are grateful to the following organiza9ons for their generous support of this mee9ng. Na#onal Eye Ins#tute “Funding for this conference was made possible (in part) by grant 1R13EY022574-‐01 from the Na9onal Eye Ins9tute. The views expressed in wriPen conference materials or publica9ons and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does men9on by trade names, commercial prac9ces, or organiza9ons imply endorsement by the U.S. Government” Founda#on Figh#ng Blindness Pro Re#na Germany Fritz Tobler Founda#on, Switzerland Deutsche ForschungsgemeinschaB, DFG, Germany We also thank Ed and Sandy Gollob for their generous support.