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Yeasts and Bacteria – Beneficial to the Gut
Yeast cohabitates in a symbiotic relationship with more
than 400 healthy intestinal bacteria. This bacteria/
yeast flora helps produce short-chain fatty acids,
vitamin K, biotin, vitamin B12, thiamin, and riboflavin.
These bacteria also keep the yeast that inhabits our
intestinal tract in check.
Candida albicans is a
particular form of yeast
found living in the intestinal
tract of most individuals. A
minute amount of Candida
present in the body is actually
beneficial; it acts as a natural
antibacterial and helps to
limit the amount of harmful
Figure 1. Candida albicans
bacteria1.
Yeast Overgrowth
The use of antibiotics or prescription steroids can often
suppress or kill the body’s good bacteria, allowing
yeast species to grow significantly. Yeast overgrowth
may result in numerous symptoms, making proper
diagnosis difficult2,3. For example, Candidiasis is an
infection that commonly affects the ears, nose, and
urinary and intestinal tracts4,5.
An overgrowth of Candida can rob your body of the
essential nutrients it needs by consuming all the sugars
and starches in your digestive tract. Symptoms of
excessive Candida can include:
•
•
•
•
•
Abdominal pain
Indigestion
Bloating
Constipation
Diarrhea
•
•
•
•
•
Menstrual irregularities
Fatigue
Food allergies
Urinary tract infections
Weight loss
If left alone, an overgrowth of Candida can eventually
lead to chronic fatigue and/or bowel disease5.
Yeast Defense
The stability of the small bowel is accomplished by
several physiologic functions:
• Stomach acid kills candida present from consumption
of foods and beverages
• Motility of the GI tract moves candida along,
preventing colonization
• Pancreatic enzymes digest and allow nutrients to be
absorbed by the body instead of yeast
• Mucosal immune response through IgA secretion
constitutes a first line of defense responsible for
neutralizing noxious antigens and pathogens
• The ileo-cecal valve prevents reflux of colonic
contents back into the small intestine
When one or more of these natural defenses
are compromised, Candida overgrowth in
the small intestine can result. The yeast
binds to the lining of the small intestine
and mounts its own defense mechanism
preventing the body from removing
it6, causing damage to the digestive
tract. By disrupting that mechanism and
establishing basal yeast levels in the
small intestine, the body’s natural
defense mechanisms can reestablish control of the normal
microbial populations needed
in order to have a healthy
digestive tract.
Figure 2. The human body utilizes
natural defense mechanisms against
Candida overgrowth in small bowel
0.7
Addition of
ThioZymeYD
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0.7
0.5
Addition of
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ThioZymeYD
Support Normal Yeast Populations
O.D 600
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O.D 600
0.5
0.7
0.3
Addition of
0.2
ThioZymeYD
0.6
0.5
O.D 600
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0.1
0.4
0
0.3
0
0.3
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Research
has shown that a formula using natural ingredients made up of
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peptides, essential oils, chelators and enzymes can reduce and suppress
0
prominent
yeast such as Candida species. This allows the body’s natural defense
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200 400 600
mechanisms a chance to re-establish control of the yeast population in the
Time (minutes)
small intestine.
ThioZyme®YD is a formulation of these ingredients, designed to
200 promote
400 600
optimal digestive tract function.
Time (minutes)
0.2
Candida
albicans
0.1
0
0
200
400
600
Candida
Time (minutes)
albicans
Candida albicans
+ ThioZymeYD
Candida albicans
+ ThioZymeYD
Graph 1. Candida albican growth with and without ThioZymeYD (minus B. subtilis, due to assay
sensitivity)
Candida albicans
Candida
+ ThioZymeYD
albicans
B. Subtilis
The formula of natural ingredients decreases
yeast growth by thousands of colonies but
does not eliminate the low amounts of yeast
that are beneficial to the gut5.
Zone of
Inhibition
Candida albicans Coated Plate
Figure 3. The natural formula is built
to establish B. subtilis in the small
intestine, allowing it to flourish and
control C. albicans growth by inhibition.
Candida albicans
Control
95 colonies at 1
million dilution
Candida albicans+
natural formula
0 colonies at 1
million dilution
Candida albicans+
natural formula
10 colonies at 1
thousand dilution
Figure 4. The natural formula changes the C. albicans
population under physiological conditions.
References:
1. Eur J Gastroenterol Hepatol. 2005 Jan; 17(1):21-6. Yeast metabolic products, yeast antigens and yeasts as
possible triggers for irritable bowel syndrome. Santelmann H, Howard JM. Holistisk Senter, Oslo, Norway.
2. Pediatr Res. 2002 Mar; 51(3):290-5. Cecal colonization and systemic spread of Candida albicans in mice
treated with antibiotics and dexamethasone. Bendel CM, Wiesner SM, Garni RM, Cebelinski E, Wells CL.
Department of Pediatrics, University of Minnesota,Minneapolis, Minnesota 55455, USA.
3. Infect Immun. 2004 Sep;72(9):4996-5003. Role of antibiotics and fungal microbiota in driving pulmonary
allergic responses. Noverr MC, Noggle RM, Toews GB, Huffnagle GB. Division of Pulmonary and Critical Care
Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 481090642, USA.
4. Gut fermentation (or the ‘Autobrewery’) Syndrome: A New Clinical Test with Initial Observations and
Discussion of Clinical and Biochemical Implications. Hunnisett A, Howard J, Davies S. J.Nutr.Med. 1990;1:338
5. Med Hypotheses. 1995 Jun; 44(6):507-15. Chronic intestinal candidiasis as a possible etiological factor in the
chronic fatigue syndrome. Cater RE 2nd.
6. Martin, Jeanne Marie and Rona, Zoltan P. The Complete Candida Yeast Guidebook. Rocklin, California:Prima
Books, 1996.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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