Spasticity Management – Dr. Manish Shah
Transcription
Spasticity Management – Dr. Manish Shah
Management of Spasticity in Children Manish N. Shah, MD Pediatric Neuroscience Symposium 5/14/2016 Director of Pediatric Spasticity and Movement Disorder Surgery Assistant Professor, Pediatric Neurosurgery The University of Texas Medical School at Houston Children’s Memorial Hermann Hospital Mischer Neuroscience Institute The University of Texas, MD Anderson Cancer Center Financial disclosures • None Overview • Introduction • Cerebral Palsy (CP) • Spasticity from CP – – – – Treatments Intrathecal Baclofen Selective Posterior Rhizotomy Selective Dorsal Rhizotomy (T.S. Park Procedure) • Indications • Treatment Description • Preop/Postop Video • Questions • Contact info Cerebral Palsy • Affects 1/500 births worldwide • Cause is unknown • Risks include prematurity, intraventricular hemorrhage and low birth weight • Has different forms – Spastic (increased tone) – Dyskinetic (variable tone) • Dystonic • Choreoathetoid/Hyperkinetic – Ataxic (decreased tone) – Mixed Let’s talk about Spasticity • Velocity-dependent abnormal stretch reflex • Abnormal imbalance between excitation and inhibition of the nervous system to the muscles • This is why your patient’s muscles are rigid and high in tone BOTH AGONIST INHIBITION EXCITATION AND ANTAGONIST MUSCLES CONTRACT AT THE SAME TIME Penn RD and Corcos DM, “Management of Spasticity by CNS Infusion Techniques”, Youmans, 2011 Spasticity Scales Brunstrom-Hernandez and Tilton, “CP, Spasticity and Dystonia,” Youmans, 2011 Gross Motor Function Classification Scale I – walks without limitations II – walks with limitations III – walks with a crutch/cane IV – limited self mobility, needs walker V – wheelchair-bound http://www.cerebralpalsy.org.nz/about/cerebral-palsy/gross-motor-function-scale/ Albright L, “ITB for CP”, Youmans, 2011 Why the legs can be more affected Periventricular Leukomalacia Limbrick and Park, “Selective Dorsal Rhizotomy for Spastic Cerebral Palsy, Youmans, 2011 Treatments • • • • • Oral Medications Botulinum Toxin (Botox) Injections Ablative Peripheral Neurotomies Intrathecal Baclofen Selective Dorsal Rhizotomy Multidisciplinary Approach! Sindou and Mertens, “Ablative Surgery for Spasticity,” Youmans, 2011 Drug Mechanism of Action GABAB receptor GABAA receptor Penn RD and Corcos DM, “Management of Spasticity by CNS Infusion Techniques”, Youmans, 2011 Oral Medications • Baclofen/Tizanidine/Diazepam • Pros: – Noninvasive • Cons: – Many children cannot tolerate the side effects • Confusion • Sedation • Potential toxicity – Not effective in every patient Botox Injections • Pros: – Target specific muscles – Relaxation seen within days and peaks at a month – Reversible • Cons: – Effects only last 3-4 months – Need repeat injections Ablative Peripheral Neurotomies • Pros: – Target specific muscles – Relaxation seen immediately – More for adults with fixed deformities • Cons: – Irreversible – “Functional” rigidity may be eliminated – Can have chronic pain when postganglionic sensory nerves are cut Intrathecal Baclofen (ITB) • Spastic Quadriplegics (both arms and legs are involved) • Multiple orthopedic procedures • Poor trunk control • Unable to become independent walkers Penn RD and Corcos DM, “Management of Spasticity by CNS Infusion Techniques”, Youmans, 2011 ITB Pump SUBFASCIAL PLACEMENT Source: Medtronic.com Intrathecal Baclofen Pump • Pros: – Reversible – Good for spastic quadriparetics • Cons: – Expensive – Needs frequent monitoring to ensure correct dose – Life-threatening baclofen withdrawal syndrome 14 year experience - Milan (n=430) 9% overall infection rate 15% overall catheter complication rate 10% for first implantation 25% of pediatric patients had at least 1 complication, mean f/u = 8.8 years Motta and Antonello, “Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience,” JNS Pediatrics, 2014 Selective Posterior Rhizotomy • Multiple methods – TS Park – 1 level lumbar laminectomy with EMG testing; 75-80% of most spastic rootlets cut – 6 level laminoplasty – L1-S1 +/- EMG testing • “Equivalent” long lasting spasticity outcomes • Risks of scoliosis only with 6 level laminoplasty • Outcomes are dose-dependent on percentage nerve rootlets sectioned (McLaughlin et al., 2002) McLaughlin 2002 Meta-analysis McLaughlin Meta-analysis 2002 • The meta-analysis of 3 RCTs concludes that SPR+PT > PT alone • Is this meta-analysis truly comparing similar operative procedures? – Vancouver: 45% rootlet sectioned • Preop exam and clinical testing – Toronto: 41% rootlets sectioned • EMG testing only to separate dorsal/ventral roots – Seattle: 25% rootlets sectioned • EMG testing • What does one conclude from n=90? Selective Dorsal Rhizotomy • • • • Spastic Diplegia and Spastic Hemiplegia patients Children and adults age 2-40 Good trunk control Can become independent walkers Limbrick and Park, “Selective Dorsal Rhizotomy for Spastic Cerebral Palsy, Youmans, 2011 SDR – modified Park Procedure • 1 level laminectomy at L1 • The dorsal roots around the spinal cord for the lower extremities are tested and the most spastic ones are cut • Surgery takes 2.5 hours • Four days in the hospital • 6-12 months of intensive rehabilitation SDR – Identification Source: Park and Johnston, “Surgical techniques of selective dorsal rhizotomy for spastic cerebral palsy: Technical note.” Neurosurg Focus 21 (2):E7, 2006 SDR – Selective Sectioning – 75% of nerve rootlets • • • • • EMG-Driven selective sectioning Divide each nerve root into 3-5 rootlets Test each rootlet for tetany threshold Grade response of each rootlet at tetany Cut 75% of the most spastic rootlets after testing them all Source: Park and Johnston, “Surgical techniques of selective dorsal rhizotomy for spastic cerebral palsy: Technical note.” Neurosurg Focus 21 (2):E7, 2006 SDR • Pros: – Immediate reduction in spasticity – Best option for spastic diplegics and hemiplegics – Child can potentially walk independently • Cons: – Not reversible – Commitment to therapy for at least 12 months postoperatively SDR Patient Video Overall SDR Outcomes • • • • >3,500 patients at St. Louis Children’s Excellent, permanent reduction in spasticity Many are independent walkers Minimal complications – Spinal fluid leak (a few patients) – Spinal fusion (1 patient) Additional SDR Outcomes • • • • • • Decreased need for orthopedic surgeries 70-80% of hip deformities unchanged postop Upper limb improvement Cognitive/language improvement Psychological improvement Anecdotal Bowel/Bladder functional improvement TCSC SDR Outcomes • All 5 patients have had their spasticity eliminated • Reduced hospital stay by 1 day • No complications • These children don’t just walk, they run and take karate! SDR vs. ITB: Different Patients! SDR ITB Low GMFCS (di-, hemi- or triplegia) Spastic cerebral palsy High GMFCS (quadriplegia) Spasticity from tumor/trauma Ambulatory Potential Wheelchair bound Minimal orthopedic intervention Multiple tendon/muscle releases Parental Commitment to Therapy Geographical commitment/closeness to academic neurosurgeon Spasticity Summary • • • • Multiple treatment options Careful patient selection Need multi-disciplinary team Need close follow up Brain MRI in CP children shows dysfunction Improved connections with therapy and stem cells Englander Z et al, Neuroimage 2015 Corticopyramidal Tract Resting State MRI Analysis Brain network analysis Temporal Latency Analysis Texas Comprehensive Spasticity Center • • • • • • • • • • Nivedita Thakur, MD – Peds Neurology Glendaliz Bosques, MD – Peds PM&R Mariana Kendrick, PT Magdalena Jungman, OT Zach Kelsey, OT Marcia Kerr, RN Paula Maldonado, MA Reyna Balderaz, MA Vianey Leang, RN Pediatric Orthopedics – Lindsay Crawford – Alfred Mansour – Shiraz Younas Thanks! • • • • PEDIATRICIANS!!! Children’s Memorial Hermann Hospital Texas Comprehensive Spasticity Center Pediatric Neurosurgery, University of Texas Health Science Center at Houston – Stephen Fletcher – David Sandberg • Mischer Neuroscience Institute • Pediatric Neurosurgery, St. Louis Children’s Hospital Questions? CONTACT INFORMATION: Manish N. Shah, MD 6410 Fannin Street, Suite 950 Houston, TX 77030 Cell: 314-302-4171 Clinic: 832-325-7242 Fax: 713-512-2221 [email protected]