Practical Course Bone Healing Models in Mice

Practical Course
Bone Healing Models in Mice
Topics
•
Murine models to study bone and bone defect healing
•
Open and closed surgical approaches
•
MouseScrew instrumentation & implantation
•
LockingMouseNail instrumentation & implantation
•
MouseFix (plate) instrumentation & implantation
•
FixEx (external fixator) instrumentation & implantation
•
Metaphyseal MouseFix instrumentation & implantation
• Scaffold implantation (femoral defect)
• Tips, tricks & pitfalls of surgical procedures
• Discussion of study designs
• Discussion of future developments
Information & Registration
Sandra Lenert
Institute for Clinical & Experimental Surgery
Saarland University
66421 Homburg/Saar
Germany
phone: +49-6841-162-6550
fax: +49-6841-162-6553
e-mail: [email protected]
Practical Course
Bone Healing Models in Mice
Location
Institute for Clinical & Experimental Surgery
Saarland University, Campus Homburg
Building 65
66421 Homburg/Saar
Germany
Organizing Committee
R. Bindl, Ulm
P. Garcia, Homburg
T. Histing, Homburg
J.H. Holstein, Homburg
A. Ignatius, Ulm
M. Klein, Homburg
R. Matthys, Davos
M.D. Menger, Homburg
T. Pohlemann, Homburg
S. Recknagel, Ulm
D. Stenger, Homburg
T. Wehner, Ulm
Sponsors
Registration Fee
Homburg/Saar
6. – 7. July, 2012
895 € including tax, course book, videos, implant materials and
diner, meals & drinks
Hotel Reservation
Sandra Lenert
Institute for Clinical & Experimental Surgery
fax: +49-6841-162-6553
e-mail: [email protected]
Arrival
by airplane:
Frankfurt, Saarbrücken, Zweibrücken, Luxemburg
by train:
ICE, EC, IC via Mannheim
by car:
A6 via Mannheim (exit Homburg)
A8 via Karlsruhe (exit Einöd)
A1/A8 via Köln, Koblenz (exit Limbach)
Department of Trauma,
Hand & Reconstructive Surgery,
Saarland University
Institute for Clinical & Experimental Surgery,
Saarland University
Research Institute,
AO Foundation, Davos
Practical Course
Program
Program
Bone Healing Models in Mice
Friday, July 6
Saturday, July 7
10:00
Welcome
Pohlemann (Homburg)
10:05
Murine models to study bone healing
Menger (Homburg)
10:20
The MouseScrew
Stenger (Homburg)
Dear colleagues, students and friends
Small animal fracture models have gained increasing interest in fracture healing research. To achieve standardized
and defined study conditions, various variables must be
carefully controlled when designing fracture healing ex10:30
MouseScrew instrumentation:
Demonstration in vitro, Matthys (Davos)
10:50
MouseScrew implantation:
Video demonstration, Stenger (Homburg)
11:00
MouseScrew implantation:
Hands on training in vivo
12:30
Lunch
13:30
The LockingMouseNail
Garcia (Homburg)
and extramedullary implants as well as open and closed
surgical approaches may be considered. During the last
few years, a variety of different, highly sophisticated implants for fracture fixation in small animals have been
developed. Rigid fixation with locking plates or external
fixators results in predominantly intramembranous healing
in both mice and rats. Locking plates, external fixators,
intramedullary screws, the locking nail and the pin-clip
device allow different degrees of stability resulting in variing. The handling of the implant materials and the implan-
13:40
LockingMouseNail instrumentation:
Demonstration in vitro, Matthys (Davos)
14:00
LockingMouseNail implantation:
Video demonstration, Garcia (Homburg)
14:10
LockingMouseNail implantation:
Hands on training in vivo
Stabilization without and with defect
15:40
Coffee break
16:10
The MouseFix (plate)
Histing (Homburg)
tation techniques require sophisticated surgical skills to
guarantee standardized study conditions. This practical
course offers the unique possibility to exercise the surgical
procedures necessary for different fixation techniques in
mice, including both intra- and extramedullary implants.
The course participants will also discuss the distinct requirements for the experimental setups as well as the
advantages and pitfalls of the different fixation techniques.
We will appreciate to welcome you to our second “practical
course on bone healing models in mice” in Homburg at the
Michael Menger
Homburg
Tina Histing
Homburg
Romano Matthys
Davos
FixEx instrumentation: Demonstration in vitro
Matthys (Davos)
9:00
FixEx implantation: Video demonstration
Bindl (Ulm)
9:10
FixEx implantation: Hands on training in vivo
Stabilization without and with defect
10:40
Coffee break
11:00
MouseFix (metaphyseal plate)
Histing (Homburg)
Discussion
11:10
Metaphyseal MouseFix instrumentation:
Demonstration in vitro, Matthys (Davos)
11:30
Metaphyseal MouseFix implantation:
Video demonstration, Histing (Homburg)
11:40
Metaphyseal MouseFix implantation:
Hands on training in vivo
Stabilization without and with defect
13:10
Lunch
14:00
Scaffold implantation in femoral defects
Klein (Homburg)
Discussion
14:10
Scaffold & LockingMouseNail instrumentation:
Demonstration in vitro, Matthys (Davos)
14:30
Scaffold & LockingMouseNail instrumentation:
Video demonstration, Klein (Homburg)
Discussion
Saarland University Campus.
Tim Pohlemann
Homburg
8:40
Discussion
ous amounts of endochondral and intramembranous heal-
The FixEx
Bindl (Ulm)
Discussion
Discussion
periments in mice. The choice of the fracture fixation technique depends on the questions addressed, whereby intra-
8:30
16:20
MouseFix instrumentation: Demonstration in vitro
Matthys (Davos)
14:40
Scaffold & LockingMouseNail instrumentation:
Hands on training in vivo
16:40
MouseFix implantation: Video demonstration
Histing (Homburg)
16:10
Biomechanical analysis in mice
Wehner (Ulm)
16:50
MouseFix implantation: Hands on training in vivo
Stabilization without and with defect
16:30
End of the Workshop
19:00
Dinner (Hemingways)