Migrol - Organia

Migrol ®
For Migraine Relief
Treat Migraine...Naturally.
Migraine headache is a neurological condition more
common to women than to men, and is unilateral and
pulsating, lasting from 4 to 72 hours; migraine might
be preceded or accompanied by a sensory warning
sign (aura), such as flashes of light, blind spots or
tingling in the arm or leg. Other symptoms include
nausea, vomiting, and extreme sensitivity to bright light
(photophobia) and noise (hyperacusis).
Migraine Initial treatment is with analgesics for
the headache, anti-emetic for the nausea, and the
avoidance of triggering conditions. While pain relieving
drugs are invaluable in treating a full blown migraine,
Migrol® offer hope for preventing and reducing the
frequency and severity of migraines.
Composition: Cynara cardunculus dried extract, tricalcium
phosphate and vitamin C (4.0 mg).
Indications:
exposed to increased concentrations of phenylephrine
with and without Migrol® extract. Treatment with
Migrol® increased vaso-constriction induced by
Migraine and tension headache.
Actions:
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Treating nervous tension.
Calming autonomic nervous system.
Reducing pain.
Reducing the inflammatory response.
What is so special about
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Migrol ® ?
Migrol ® is a unique and natural product that helps
in the treatment of Migraine.
Reduces the frequency, and/or reduce the severity
of migraine symptoms.
Possess anti inflammatory effect.
Possess powerful anti oxidant effect.
Safe natural product.
Scientific Data:
Migraine is believed to be caused by
cerebral blood vessels relaxation
and presence of soft inflammation.
The research strategy in finding
antimigraine product was to
promote cerebral vasoconstriction
and reduce inflammation levels.
1. Vasoconstriction Activity of
Migrol® Extract.
To investigate the effect of Migrol® on
blood vessels, rat intestine vein rings were
used in an isolated organ bath system. The rings were
phenylephrine in a concentration-dependent manner
(fig-1). This indicates the ability of Migrol® to
cause vasoconstriction in cerebral blood
vessels.
2. Anti-inflammatory Activity of
Migrol® extract:
Lipopolysaccharide (LPS) is a
major cell wall component of Gramnegative bacteria and its signaling in
macrophages induces the production
of pro-inflammatory molecules such
as nitric oxide (NO). As indicated in Fig
2, Migrol® extract (10 μg/ml) significantly
inhibited LPS-induced NO production, in
hepatocytes and macrophage-like THP-1 cells.
This observation suggests that Migrol® extract displayed
a strong anti-inflammatory effect and protects against
LPS-induced inflammation.
significant and
dose-dependent. This means that
Migrol® has a protective effects against cellular damage
by lipid peroxidation and reactive oxygen species (ROS)
generated by oxidative stress (fig 4).
Conclusion:
As
natural
treatment
for
migraine,
Migrol®reduces the frequency, and the severity of
migraine symptoms. It possess; anti-inflammatory,
anti-oxidative and antispasmodic effects. Regular use
of Migrol® will reduce dramatically the chances of
migraine recurring.
References:
3. Anti-oxidant Effect of Migrol® extract:
Oxidative stress leads to generation of reactive oxygen
species (ROS) which play an important pathogenetic
role in different disease-states. The main damage
to cells results from the ROS-induced alteration of
macromolecules such as lipid peroxidation in membrane
lipids, essential proteins, and DNA. Lipid peroxidation
has damaging effects on cell membranes.
The extent of lipid peroxidation was measured using
a technique based on a thiobarbituric acid reactive
substance (TBARS) assay that detects malondialdehyde
(MDA), an end product of peroxidative decomposition
of polyeonic fatty acids in in-vitro systems. Antioxidant
properties of Migrol® were investigated in rat liver cells.
As shown in fig-3 the antioxidant effect of Migrol®was
Fig-4 Migrol ® action in oxidative stress
1.
British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K.:
British Herbal Medicine Association.
2.
Bruneton, J. 1995. Pharmacognosy, Phytochemistry,Medicinal
Plants. Paris: Lavoisier Publishing.
3.
Budavari, S. (ed.). 1996. The Merck Index: An Encyclopedia
of Chemicals, Drugs, and Biologicals, 12th ed. Whitehouse
Station, N.J.: Merck & Co, Inc. 467-468.
4.
Lietti, A. 1977. Choleretic and cholesterol lowering properties
of two artichoke extracts. Fitoterapia (48):153-158.
5.
Reynolds, J.E.F. (ed.). 1982. Martindale: The Extra
Pharmacopoeia, 28th ed. London: The Pharmaceutical
Press.
6.
Gallagher RM, Cutrer FM (2002). “Migraine: diagnosis,
management, and new treatment options”. Am J Manag
Care 8 (3 Suppl): S58–73.
7.
The International Classification of Headache Disorders, 2nd
Edition.