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THE CLINICIAN’S GUIDE TO SPLENDA®
What is SPLENDA® Low Calorie Sweetener
and what is its chemical structure?
SPLENDA® Sweeteners are low calorie sweetening products containing sucralose.
Sucralose is produced through a patented process that starts with sugar (sucrose) and
replaces 3 hydrogen-oxygen groups with 3 chlorine atoms. But SPLENDA® is not sugar.
It is an exceptionally stable molecule that passes through the body without being broken
down for energy.
CH2OH
CH2OH
O
CH2OH
CI
O
OH
HO
OH
O
HO
O
CH2OH
OH
Sucrose (C12H22011)
O
OH
HO
O
CH2CI
OH
CH2CI
OH
Sucralose (C12H19CI3O8)
Can patients with diabetes use SPLENDA® Low Calorie Sweetener?
Yes. Clinical studies have shown that SPLENDA® does not affect blood glucose levels,
insulin, or HbA1c.1-3 Like other low-calorie sweeteners, the granulated and sachet products
contain small amounts of carbohydrate to provide needed volume and texture.
Can children use SPLENDA® Low Calorie Sweetener?
Yes. SPLENDA® can be used by everyone, including children of all ages. SPLENDA®
Sweetener products are a great way to reduce the amount of added sugars children
consume daily and may even help increase their intake of healthy foods. What’s more,
SPLENDA® can be a useful tool for managing overweight children, children with type
1 or type 2 diabetes, or those at risk of diabetes, by helping to reduce calories and
carbohydrates from sugar.
Can pregnant and lactating women use SPLENDA® Low Calorie Sweetener?
Yes. SPLENDA® may be used as part of a healthy prenatal and postnatal diet. Studies that
specifically examined the potential effects of sucralose on embryo-foetal development
showed no birth defects or any other effect that would compromise normal development.3
For patients with gestational diabetes, SPLENDA® can help reduce carbohydrate intake
from sugar to help with appropriate meal planning.
2
How can SPLENDA® Low Calorie Sweetener
help with weight management?
SPLENDA® Sweetener can help decrease caloric intake by replacing sugar and,
when used in conjunction with regular physical activity, can be an effective way to help
with weight management.
A 2007 study published in Pediatrics, demonstrated that by
making two simple changes daily,
1. Using SPLENDA® as part of a program to reduce calorie
intake.
2. Increasing activity levels, families can help overweight
children slow their rate of weight gain.5
Numerous randomised, placebo-controlled studies have
shown non-nutritive sweeteners to be an effective weight
management tool and their potential for positive impact has
been reaffirmed in a recent meta-analysis study.6-8
In addition, noted New York Times columnist Jane E.
cites research to emphasise that, when used properly
energy-yielding sweeteners, low-calorie sweeteners can
As she reported, “Small changes in caloric intake
meaningful healthier weights.”9
Brody (February 17, 2009)
as a substitute for higheraid in weight management.
can result in small but
To assist in lowering BMI, reduce the risk of obesity and indirectly the risk of cardiovascular
disease, high carbohydrate eating patterns, particularly if high in sucrose and fructose
should be avoided. Healthy eating for weight loss involves choosing foods lower in energy
(kilojoules) and being mindful of how much of the food is being eaten.10
Using products sweetened with SPLENDA® is a great way to help patients reduce their
daily sugar consumption - without sacrificing taste.
3
Is SPLENDA® Low Calorie Sweetener metabolised by the body?
SPLENDA®
Low
Calorie
Sweetener
contains
sucralose.
Most
sucralose
(about 85%) is not absorbed and is excreted unchanged in the stool.
A small amount (about 15%) is absorbed via passive diffusion, but this is not broken down
for energy or to yield smaller molecules in the body. Radiolabel studies showed sucralose
is not actively transported across the blood-brain barrier, the placental barrier, or the
mammary glands. Most absorbed sucralose is excreted in the urine within 24 hours. 3,11
Does SPLENDA® Low Calorie Sweetener have any side effects - is it safe?
SPLENDA® has no known side effects. Sucralose has been the subject
of
extensive
safety
testing,
with
more
than
20
years
of
research
and over 110 scientific studies. 3,4,12 Its safety is well documented and Food Standards
Australia and New Zealand (FSANZ), along with regulatory, health, and food safety
authorities from around the world, have confirmed that it is safe. 3,4,12-14 There are no
warning labels on the products to exclude anyone from enjoying SPLENDA®.
Does SPLENDA® Low Calorie Sweetener cause tooth decay?
No. Sucralose, the low-calorie sweetening ingredient in all SPLENDA® Sweetener Products,
is not cariogenic. Studies show that SPLENDA® Sachet and Granulated products, which
contain small amounts of carbohydrate per serving (to add volume), are significantly less
cariogenic than sugar. 3,15
4
Does SPLENDA® Low Calorie Sweetener cause headaches/migraines?
No. Research does not support that SPLENDA® would cause migraines or headaches and
there are no adverse effects expected with its use.3,12-14 Headaches and migraines are very
common and may be caused by many things.
Will SPLENDA® Low Calorie Sweetener cause
gastrointestinal (GI) issues?
No. SPLENDA® does not cause any GI side effects. More than 20 years of research and
over 110 scientific studies confirm the safety of sucralose.3,4,12
It is important to note that SPLENDA® is often used in foods like
ice cream or chocolate that also contain sugar alcohols. Some individuals
are sensitive to sugar alcohols (such as mannitol, sorbitol, xylitol, lactitol,
maltitol). Sugar alcohols are known to cause bloating and diarrhoea if
consumed in large enough quantities.
5
SPLENDA® Low Calorie Sweetener contains chlorine.
Is that safe?
Yes. Chlorine is an element in daily life. It is a natural component of table salt, and salt is
naturally present in many foods, such as lettuce, tomatoes, mushrooms, and peanut butter.
Chlorine is also part of more complex molecules naturally found in other foods like
lentils, peas, and potatoes. Chlorine is also added to most public drinking water supplies.
Chlorine is used in a patented process that modifies sugar (sucrose) to result in the
exceptionally stable low-calorie sweetener, sucralose. It is the presence of the chlorine
atoms in sucralose that prevents it from being broken down in the body for energy and
makes it non-caloric.
Extensive research shows that SPLENDA® can be used safely by everyone and there is no
cause for concern about safety due to the presence of chlorine.3,11-14
Does SPLENDA® Low Calorie Sweetener contain aspartame?
No, SPLENDA® does not contain aspartame. Aspartame is another low-calorie sweetener
unrelated to sucralose.
6
How does SPLENDA® Low Calorie Sweetener compare
to other sweeteners?
SPLENDA ®
taste
of
has
some
and acesulfame-K.
a
clean,
other
16-18
sugar-like
low-calorie
taste
without
sweeteners,
the
such
bitter
as
after-
saccharin
And unlike aspartame, it holds up to higher heat, so it can be
used in cooking and baking. 18
SPLENDA® is found in more than 4000 products worldwide and helps make it possible
to plan healthy meals. Current dietary guidelines recommend that everyone reduce
added sugar in their daily diets. SPLENDA® is a great way to help.
Cooking with SPLENDA®
Because of the excellent heat stability of sucralose, SPLENDA® Granulated Sweetener,
unlike some other low-calorie sweeteners, can be used almost anywhere sugar is used in
cooking and baking. SPLENDA® Granulated Sweetener works best in recipes where sugar
is used primarily to sweeten (rather than for structure or volume), such as pie fillings,
cheesecakes, sweet sauces, marinades and glazes. SPLENDA® Granulated Sweetener also
works well in quick breads, muffins and biscuits.
For delicious recipes and hints on achieving the best results when cooking with SPLENDA®,
please visit www.splenda.com.au or www.splenda.co.nz.
7
What’s in SPLENDA® Sweetener Products?
All SPLENDA® products contain sucralose. It gives our products the sweet taste people love
without the calories.
Like other low-calorie sweeteners, the granulated and packet products of SPLENDA® Low
Calorie Sweetener contain small amounts of carbohydrate to provide needed volume and
texture. These common food ingredients contribute so few calories per serving that these
products meet the FSANZ criteria for low-calorie foods.
No Dairy
or Animal
Products
AspartameFree
GlutenFree
SPLENDA®
Low-Calorie
Sweetener Tablets
✓
✓
SPLENDA®
Low-Calorie
Sweetener Sachets
✓
✓
✓
✓
✓
✓
SPLENDA®
Low-Calorie
Granulated Sweetener
✓
✓
✓
✓
✓
✓
LactoseFree
Kosher
Halal
✓
Are there any known interactions with
medications and SPLENDA® Low Calorie Sweetener?
No.
There
Sucralose
are
(the
no
known
sweetener
interactions
in
with
SPLENDA®)
is
medications
a
very
and
stable
SPLENDA®.
molecule.
There are no warning labels or other information statements required to limit its use.
8
The SPLENDA® Low Calorie Sweetener Range
SPLENDA® Granulated Sweetener
1 teaspoon = the sweetness of 1 teaspoon of sugar.
Suitable for hot and cold drinks, sprinkling on cereal,
cooking and baking.
Energy per teaspoon: 2 calories (8 kJ).
SPLENDA® Sachets
1 sachet = the sweetness of 2 teaspoons of sugar.
Suitable for hot and cold drinks, sprinkling on fruit and
cereal, and comes in a convenient pack for out-of-home use.
Energy per sachet: 4 calories (15 kJ).
SPLENDA® Tablets
1 tablet = the sweetness of 1 teaspoon of sugar.
Suitable for adding to tea or coffee and comes in a
convenient, portable dispenser pack.
Energy per tablet: 0.2 calories (0.8 kJ).
9
References:
1. Grotz VL, Henry RR, McGill JB, et al. Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Asoc. 2003;103(12):1607-1612. 2. Mezitis NHE, Maggio CA, Koch P, Quddoos A,
Allison DB, Pi-Sunyer FX. Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes. Diabetes Care. 1996;19(9):1004-1005. 3. Grotz VL, Munro IC. An overview of the safety
of sucralose. Regul Toxicol Pharmacol. 2009;55(1):1-5. 4. Food Standards Australia New Zealand website, available at www.foodstandards.gov.au (accessed 10 November 2009) 5. Rodearmel SJ, Wyatt HR, Stroebele N,
Smith SM, Ogden LG, Hill JO. Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: the America on the Move family study. Pediatrics. 2007;120(4):e869-e879. 6. de
la Hunty A, Gibson S, Ashwell M. A review of the effectiveness of aspartame in helping with weight control. Nutr Bull. 2006;31(2):115-128. 7. Rolls BJ. Effects of intense sweeteners on hunger, food intake, and body
weight: a review. Am J Clin Nutr. 1991;53(4):872-878. 8. Mattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr.
2009;89(1):1-14. 9. Brody JE. Sweeteners: real aid or excuse to indulge? NY Times. February 17, 2009. http://query.nytimes.com/gst/fullpage.html?res=9B03EEDF163EF934A25751C0A96F9C8B63. Accessed February
26, 2009. 10. National Heart Foundation of Australia, Position Statement: Carbohydrates, dietary fibre, glycaemic index/load and cardiovascular disease. Questions and Answers – Health Professionals, February 2006
11. Sucralose Safety Assessment. Food Chem Toxicol. 2000;38 (suppl 2):S1-S129. 12. FDA approves new high-intensity sweetener sucralose [FDA talk paper]. FDA Web site. http://vm.cfsan.fda.gov/~lrd/tpsucral.html.
Published April 1, 1998. Accessed September 14, 2009. 13. Food additives permitted for direct addition to food for human consumption; sucralose. Fed. Regist. 1998:63(65):16417-16433. 14. Food additives permitted
for direct addition to food for human consumption; sucralose. Fed. Regist. 1999:64(155):43908-43909. 15. Mandel ID, Grotz VL. Dental considerations in sucralose use. J Clin Dent. 2002;13(3):116-118. 16. Kuhn C,
Bufe B, Winnig M, et al. Bitter taste receptors for saccharin and acesulfame K. J Neurosci. 2004;24(45):10260-10265. 17. Horne J, Lawless HT, Speirs W, Sposato D. Bitter taste of saccharin and acesulfame-K. Chem
Senses. 2002;27:31-38. 18. Nelson AL. Sweeteners: Alternative—Practical Guides for the Food Industry. St Paul, MN: Eagan Press; 2000.
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RESOURCES FOR YOU AND YOUR PATIENTS
Complimentary brochures, recipes and product samples of SPLENDA®
are available for you to hand out to your patients.
If you would like to receive any of these materials,
simply contact our Consumer Service Centre:
Australia: 1800 811 410
New Zealand: 0800 44 1745
Johnson & Johnson Pacific
Locked Bag 5, Broadway NSW 2007, Australia
For more information on SPLENDA® visit our website:
www.splenda.com.au
www.splenda.co.nz
© Registered Trade Mark McNeil Nutritionals, LLC © Johnson & Johnson Pacific Pty Ltd. 2011 1064/11