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Typhoid fever
From Wikipedia, the free encyclopedia
This article is about typhoid fever. For an unrelated disease with a similar name, see typhus. For a related disease which is caused by two different bacteria, see Paratyphoid fever. For the character in the 2006 film Elektra, see Typhoid (Elektra). Navigation
Main page Contents Featured content Current events Random article Donate to Wikipedia Typhoid fever, also known as typhoid, [1] is a common worldwide illness, transmitted by the ingestion of food or water contaminated with the feces of an infected person, which contain the Typhoid Fever(strong disease)
[2][3]
Classification and external resources
bacterium Salmonella enterica, serovar Typhi.
The bacteria then perforate through the intestinal wall and are phagocytosed by macrophages. The organism is a Gram­negative short bacillus that is motile due to its peritrichous flagella. The bacterium grows best at 37°C / 98.6°F – human body temperature. This fever received various names, such as gastric fever, abdominal typhus, infantile remittant fever, slow fever, nervous fever, pythogenic fever, etc. The name of "typhoid" comes from the neuropsychiatric symptoms common to typhoid and typhus (from Greek τῦϕος, "stupor").[4] Interaction
Help About Wikipedia The impact of this disease fell sharply with the application of modern sanitation techniques. Community portal Recent changes Contact Wikipedia Contents 1 Signs and symptoms What links here Related changes Upload file ICD­10
A01.0
3 Diagnosis of typhoid ICD­9
002
4 Prevention DiseasesDB
27829
5 Treatment 5.1 Resistance eMedicine
oph/686
MeSH
D014435
6 Epidemiology Special pages Typhi
2 Transmission 2.1 Possible protective effects of heterozygosity for cystic fibrosis Toolbox
Rose spots on the chest of a patient with typhoid fever due to the bacterium Salmonella med/2331
7 History Permanent link 7.1 Famous victims Cite this page 7.2 In fiction 8 See also Print/export
9 References 9.1 Further reading Create a book
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Signs and symptoms
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Typhoid fever is characterized by a slowly progressive fever as high as 40 °C (104 °F), profuse sweating and gastroenteritis. Less commonly, a rash of flat, rose­colored spots may appear.[5] Afrikaans ‫ﺍﻟﻌﺮﺑﻴﺔ‬ Classically, the course of untreated typhoid fever is divided into four individual stages, each lasting approximately one week. In the first week, there is a slowly rising temperature with relative bradycardia, malaise, headache, and cough. A bloody nose (epistaxis) is seen in a quarter of cases and abdominal pain is also possible. There is leukopenia, a decrease in the number of circulating white blood cells, with eosinopenia and relative lymphocytosis, a positive reaction and blood cultures are positive for Salmonella typhi or paratyphi. The classic Widal test is negative in the first week. Brezhoneg Български Català Česky Dansk In the second week of the infection, the patient lies prostrate with high fever in plateau around 40 °C (104 °F) and bradycardia (sphygmothermic dissociation), classically with a dicrotic pulse wave. Delirium is frequent, frequently calm, but sometimes agitated. This delirium gives to typhoid the nickname of "nervous fever". Rose spots appear on the lower chest and abdomen in around a third of patients. There are rhonchi in lung bases. The abdomen is distended and painful in the right lower quadrant where borborygmi can be heard. Diarrhea can occur in this stage: six to eight stools in a day, green with a characteristic smell, comparable to pea soup. However, constipation is also frequent. The spleen and liver are enlarged (hepatosplenomegaly) and tender, and there is elevation of liver transaminases. The Widal reaction is strongly positive with antiO and antiH antibodies. Blood cultures are sometimes still positive at this stage. (The major symptom of this fever is that the fever usually rises in the afternoon up to the first and second week.) Deutsch Eesti Español Euskara ‫ﻓﺎﺭﺳﯽ‬ Français 한국어
ह द In the third week of typhoid fever, a number of complications can occur: Hrvatski Bahasa Indonesia Interlingua Íslenska Intestinal hemorrhage due to bleeding in congested Peyer's patches; this can be very serious but is usually not fatal. Intestinal perforation in the distal ileum: this is a very serious complication and is frequently fatal. It may occur without alarming symptoms until septicaemia or diffuse peritonitis sets in. Encephalitis Italiano Neuropsychiatric symptoms (described as "muttering delirium" or "coma vigil"), with picking at bedclothes or imaginary objects. ‫עברית‬ ಕನ ಡ Metastatic abscesses, cholecystitis, endocarditis and osteitis The fever is still very high and oscillates very little over 24 hours. Dehydration ensues and the patient is delirious (typhoid state). By the end of third week the fever has started reducing this (defervescence). This carries on into the fourth and final week. Kiswahili Kurdî Latina Transmission
Magyar മലയാളം
Bahasa Melayu Nederlands [edit]
Flying insects feeding on feces may occasionally transfer the bacteria through poor hygiene habits and public sanitation conditions. Public education campaigns encouraging people to wash their hands after defecating and before handling food are an important component in controlling spread of the disease. According to statistics from the United States Centers for Disease Control and Prevention (CDC), the chlorination of drinking water has led to dramatic decreases in the transmission of typhoid fever in the U.S. [edit]
日本語
Norsk (bokmål) Norsk (nynorsk) Polski Português Română Русский Simple English Slovenčina Српски / Srpski Srpskohrvatski / Српскохрватски Suomi Svenska தமி
ల
ె గ ไทย Українська Tiếng Việt 中文
A person may become an asymptomatic carrier of typhoid fever, suffering no symptoms, but capable of infecting others. According to the CDC approximately 5% of people who contract typhoid continue to carry the disease after they recover. The most famous asymptomatic carrier was Mary Mallon (commonly known as "Typhoid Mary"), a young cook who was responsible for infecting at least 53 people with typhoid, three of whom died from the disease.[6] Mallon was the first apparently perfectly healthy person known to be responsible for an "epidemic". Many carriers of typhoid were locked into an isolation ward never to be released in order to prevent further typhoid cases. These people often deteriorated mentally, driven mad by the conditions they lived in.[7] Possible protective effects of heterozygosity for cystic fibrosis
[edit]
It has been hypothesized that cystic fibrosis may have risen to its present levels (1 in 1600 in UK) due to the heterozygous advantage that it confers against typhoid fever.[8] The CFTR protein is present in both the lungs and the intestinal epithelium, and the mutant cystic fibrosis form of the CFTR protein prevents entry of the typhoid bacterium into the body through the intestinal epithelium. However, the heterozygous advantage hypothesis was proposed in one review in which the author himself writes, "Although cellular/molecular evidence presently is not available for this hypothesis, the CF mutation may be one of several mutations that have spread in European populations because they increased resistance to infectious diseases." Since no molecular experimental evidence has been presented in support of this theory, this theory is not accepted by the majority of the scientific community. Diagnosis of typhoid
[edit]
Diagnosis is made by any blood, bone marrow or stool cultures and with the Widal test (demonstration of salmonella antibodies against antigens O­somatic and H­flagellar). In epidemics and less wealthy countries, after excluding malaria, dysentery or pneumonia, a therapeutic trial time with chloramphenicol is generally undertaken while awaiting the results of Widal test and cultures of the blood and stool.[9] The Widal test is time consuming and oftentimes when diagnosis is reached it is too late to start an antibiotic regimen. The term "enteric fever" is a collective term that refers to typhoid and paratyphoid.[10]
Prevention
[edit]
Main article: Typhoid vaccine Sanitation and hygiene are the critical measures that can be taken to prevent typhoid. Typhoid does not affect animals and therefore transmission is only from human to human. Typhoid can only spread in environments where human feces or urine are able to come into contact with food or drinking water. Careful food preparation and washing of hands are crucial to preventing typhoid. There are two vaccines currently recommended by the World Health Organization for the prevention of typhoid:[11] these are the live, oral Ty21a vaccine (sold as Vivotif Berna) and the injectable Typhoid polysaccharide vaccine (sold as Typhim Vi by Sanofi Pasteur and Typherix by GlaxoSmithKline). Both are between 50% to 80% protective and are recommended for travelers to areas where typhoid is endemic. Boosters are recommended every 5 years for the oral vaccine and every 2 years for the injectable form. There exists an older killed whole­cell vaccine that is still used in countries where the newer preparations are not available, but this vaccine is no longer recommended for use, because it has a higher rate of side effects (mainly pain and inflammation at the site of the injection).[11] Treatment
Doctor administering a typhoid vaccination at a school in San Augustine County, Texas [edit]
The rediscovery of oral rehydration therapy in the 1960s provided a simple way to prevent many of the deaths of diarrheal diseases in general. Where resistance is uncommon, the treatment of choice is a fluoroquinolone such as ciprofloxacin[10]
[12]
otherwise, a third­generation cephalosporin such as ceftriaxone or cefotaxime is the first choice.
[13][14][15]
Cefixime is a suitable oral alternative.[16][17] Typhoid fever in most cases is not fatal. Antibiotics, such as ampicillin, chloramphenicol, trimethoprim­sulfamethoxazole, Amoxicillin and ciprofloxacin, have been commonly used to treat typhoid fever in developed countries. Prompt treatment of the disease with antibiotics reduces the case­fatality rate to approximately 1%. 1939 conceptual illustration showing various ways that typhoid bacteria can contaminate a water well (center) When untreated, typhoid fever persists for three weeks to a month. Death occurs in between 10% and 30% of untreated cases[citation needed]. In some communities, however, case­fatality rates may reach as high as 47%.[citation needed] Resistance
[edit]
Resistance to ampicillin, chloramphenicol, trimethoprim­sulfamethoxazole and streptomycin is now common, and these agents have not been used as first line treatment now for almost 20 years.[citation needed] Typhoid that is resistant to these agents is known as multidrug­resistant typhoid (MDR typhoid). Ciprofloxacin resistance is an increasing problem, especially in the Indian subcontinent and Southeast Asia. Many centres are therefore moving away from using ciprofloxacin as first line for treating suspected typhoid originating in South America, India, Pakistan, Bangladesh, Thailand or Vietnam. For these patients, the recommended first line treatment is ceftriaxone. It has also been suggested Azithromycin is better at treating typhoid in resistant populations than both fluoroquinolone drugs and ceftriaxone.[18] Azithromycin significantly reduces relapse rates compared with ceftriaxone. There is a separate problem with laboratory testing for reduced susceptibility to ciprofloxacin: current recommendations are that isolates should be tested simultaneously against ciprofloxacin (CIP) and against nalidixic acid (NAL), and that isolates that are sensitive to both CIP and NAL should be reported as "sensitive to ciprofloxacin", but that isolates testing sensitive to CIP but not to NAL should be reported as "reduced sensitivity to ciprofloxacin". However, an analysis of 271 isolates showed that around 18% of isolates with a reduced susceptibility to ciprofloxacin (MIC 0.125–1.0 mg/l) would not be picked up by this method.[19] It is not certain how this problem can be solved, because most laboratories around the world (including the West) are dependent on disc testing and cannot test for MICs. Epidemiology
With an estimated 16–33 million cases of annually resulting in 216,000 deaths in endemic areas, the World Health Organization identifies typhoid as a serious public health problem. Its incidence is [edit]
highest in children and young adults between 5 and 19 years old.[20] History
[edit]
Around 430–424 BC, a devastating plague, which some believe to have been typhoid fever, killed one third of the population of Athens, including their leader Pericles. The balance of power shifted from Athens to Sparta, ending the Golden Age of Pericles that had marked Athenian dominance in the ancient world. Ancient historian Thucydides also contracted the disease, but he survived to write about the plague. His writings are the primary source on this outbreak and modern academics and medical scientists consider epidemic typhus the most likely cause; a 2006 study detected DNA Incidence of typhoid fever ♦ Strongly endemic ♦ Endemic ♦ Sporadic cases sequences similar to those of the bacterium responsible for typhoid fever.[21] However the cause of the plague has long been disputed and other scientists have disputed the findings, citing serious methodologic flaws in the dental pulp­derived DNA study.[22] The disease is most commonly transmitted through poor hygiene habits and public sanitation conditions; during the period in question, the whole population of Attica was besieged within the Long Walls and lived in tents. Death rates for typhoid fever in the U.S. 1906–1960 Some historians believe that in the English colony of Jamestown, Virginia, typhoid fever killed more than 6000 settlers between 1607 and 1624.[23] During the American Civil War, 81,360 Union soldiers died of typhoid or dysentery.[24] In the late 19th century, typhoid fever mortality rate in Chicago averaged 65 per 100,000 people a year. The worst year was 1891, when the typhoid death rate was 174 per 100,000 people.[25] The most notorious carrier of typhoid fever—but by no means the most destructive—was Mary Mallon, also known as Typhoid Mary. In 1907, she became the first American carrier to be identified and traced. She was a cook in New York. She is closely associated with fifty­
three cases and three deaths.[26] Public health authorities told Mary to give up working as a cook or have her gall bladder removed. Mary quit her job but returned later under a false name. She was detained and quarantined after another typhoid outbreak. She died of pneumonia after 26 years in quarantine. In 1880 Karl Joseph Eberth described a bacillus that he suspected was the cause of typhoid. In 1884 pathologist Georg Theodor August Gaffky (1850–1918) confirmed Eberth's findings, and the organism was given names such as Eberth's bacillus, Eberthella typhi and Gaffky­Eberth bacillus. Today the bacillus that causes typhoid fever goes by the scientific name of Salmonella enterica enterica, serovar Typhi. Mary Mallon ("Typhoid Mary") in a hospital bed (foreground). She was forcibly quarantined as a carrier of typhoid fever in 1907 for three years and then again from 1915 until her death in 1938. In 1897, Almroth Edward Wright developed an effective vaccine. In 1909, Frederick F. Russell, a U.S. Army physician, developed an American typhoid vaccine and two years later his vaccination program became the first in which an entire army was immunized. It eliminated typhoid as a significant cause of morbidity and mortality in the U.S. military. Most developed countries saw declining rates of typhoid fever throughout the first half of the 20th century due to vaccinations and advances in public sanitation and hygiene. Antibiotics were introduced in clinical practice in 1942, greatly reducing mortality. Today, incidence of typhoid fever in developed countries is around 5 cases per 1,000,000 people per year. An outbreak in the Democratic Republic of Congo in 2004–05 recorded more than 42,000 cases and 214 deaths.[20]
Typhoid fever was also known as suette milliaire in nineteenth­century France. Famous victims
[edit]
Famous people who have had the disease include Baiju Bawra aka (Baijnath Prasad or Baijnath Mishra), the great Indian singer, musician died of typhoid at the age of 71 on the eve of the Indian festival, Basant Panchami in Vikram Samvat 1670 (1613 CE). Hashimoto Hakaru, discoverer Of Autoimmune Thyroiditis Hashimoto's thyroiditis. Died on January 9, 1934, of typhoid fever. Mary Mallon, more commonly known as Typhoid Mary, survived a childhood episode in Ireland to become an asymptomatic carrier in the United States. Abigail Adams, second First Lady of the United States, wife of John Adams, died of typhoid fever on October 28, 1818. Prince Albert of Saxe­Coburg­Gotha, British prince consort, Queen Victoria's husband, died of typhoid Fever on 14 December 1861. Lizzie van Zyl was a child inmate in a British­run concentration camp in South Africa who died from typhoid fever during the Boer War (1899–1902). Edward VII survived. Joseph Smith, founder of the Church of Jesus Christ of Latter­day Saints Latter Day Saint movement, contracted typhoid as a child, survived. Henry Frederick, Prince of Wales Princess Victoria of Hesse and by Rhine survived. Princess Leopoldina of Brazil, Emperor Pedro II of Brazil's daughter, died of typhoid Fever on 7 February 1871. Tadeusz Kosciuszko, hero of the American Revolution and Polish patriot leader, died of typhoid Fever in Switzerland, 1817. Louisa May Alcott, author of Little Women, records contracting it in Hospital Sketches. Charles Darwin, naturalist, during his visit to Chile with HMS Beagle in 1835. Ignacio Zaragoza, Mexican general and Cinco de Mayo hero. Died of typhoid fever in less than 5 months of his famous victory over the French army in Puebla on September 8, 1862. Urilla Sutherland Earp, first wife of Marshall Wyatt Earp, probably died of Typhoid Fever in or around 1870 in Lamar Township, Missouri. Eugenia Tadolini, a celebrated Italian soprano, died of the disease in Paris in 1872. Leland Stanford Jr. died of typhoid in 1884; his parents founded Stanford University in his memory. William Wallace Lincoln, third son of Abraham Lincoln, the 16th President of the United States, died February 20, 1862 of typhoid fever. Mary Todd Lincoln, wife of Abraham Lincoln. Thoby Stephen, elder brother of novelist Virginia Woolf, died of typhoid fever in 1906 at age 26. The deaths of Woolf's characters, Jacob in Jacob's Room and Percival in The Waves, are based on Thoby's. Wilbur Wright, one of the famous Wright Brothers. Died May 30, 1912 of typhoid fever. Frank McCourt, author of Angela's Ashes. In his memoir, he details nearly dying of the disease in 1940 as a ten­year­old in Limerick, Ireland, and his ensuing 4­month­long hospital stay. Stephen Douglas, politician and 1860 presidential runner­up. Dr HJH 'Tup' Scott, captain of the 1886 Australian cricket team that toured England, died of typhoid in 1910.[27] Arnold Bennett, English novelist, died in 1931 of typhoid, two months after drinking a glass of water in a Paris Hotel to prove it was safe.[28] Raymond Radiguet, French literary prodigy, died of typhoid at age 20 while on a trip with his mentor, Jean Cocteau. Keshav Baliram Hedgewar, founder and first Sarsanghchalak of Rashtriya Swayamsevak Sangh, died of typhoid at age 51 on 1940/06/21. Gerard Manley Hopkins, Jesuit and poet. Ralph Rose, three­time Olympic champion and six­time medalist in throwing events, died of typhoid on October 16, 1913 at age 28. Roger Sherman, a Founding Father of the United States of America. Georgia O'Keeffe, a famous painter, survived Ravi Shankar, musician, survived[29] Tsar Nicholas II of Russia had typhoid in 1900, survived. Heath Bell, Relief Pitcher San Diego Padres acquired on 2010 trip to Fiji, survived. In fiction
[edit]
Gilbert Blythe (of the Anne of Green Gables series) almost dies of typhoid fever in Anne of the Island by L.M. Montgomery. Walter Blythe (son of Anne and Gilbert Blythe in the latter Anne of Green Gables books) was in recovery from typhoid in "Rilla of Ingleside" and this is seen as the reason why he does not enlist at the onset of WWI. Johann "Hanno" Buddenbrook, in Thomas Mann's novel, Buddenbrooks, dies of typhoid fever, and the book includes a long medical description of the disease and its effects. John H. Watson (Sherlock Holmes' famed companion) nearly died of typhoid contracted in India, and returned to England for convalescence – where he first met the detective. Scarlett O'Hara's mother in Gone With the Wind. Suttree in the Cormac McCarthy novel of the same name nearly dies of typhoid fever in the final scenes of the novel. In the 1950 western Stars in My Crown, the town is devastated by typhoid spread by a school's well. Port Moresby in Paul Bowles' The Sheltering Sky, in North Africa Jane Eyre and her husband, Jane's parents, in 'Jane Eyre' by Charlotte Brontë Joey, one of the few remaining human survivors who can read, dies of typhoid fever in George Stewart's Earth Abides. Yevgeny Vassilievitch Bazarov, the nihilist in Ivan Turgenev's Fathers and Sons, dies of typhoid fever contracted through a cut in his finger near an infected corpse. See also
[edit]
Kauffman­White classification References
[edit]
1.
^ MedlinePlus Encyclopedia Typhoid fever
2.
^ Giannella RA (1996). "Salmonella"
9631172­1­1. 3.
4.
^ http://www.cdc.gov/ncidod/dbmd/diseaseinfo/TyphoidFever_g.htm ^ Oxford English Dictionary. typhoid, adj. and n. and typhus, n. Online version March 2011. Retrieved May 2011. 5.
^ CDC Disease Info typhoidfever_g
6.
^ "'Typhoid Mary' Dies Of A Stroke At 68. Carrier of Disease, Blamed for 51 Cases and 3 Deaths, but She Was Held Immune" . New York Times. November 12, 1938. Retrieved 2010­02­28. "Mary Mallon, the first carrier of typhoid bacilli identified in America and consequently known as Typhoid Mary, died yesterday in Riverside Hospital on North Brother Island." 7.
8.
^ BBC on Long Grove Hospital Surrey GB url: http://news.bbc.co.uk/today/hi/today/newsid_7523000/7523680.stm ^ Weinberg ED (2008). "Survival advantage of the hemochromatosis C282Y mutation" . Perspectives in biology and medicine 51 (1): 98–102. doi:10.1353/pbm.2008.0001 . PMID 18192769 . 9.
^ Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0838585299. . Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0­
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^ a b Parry CM, Beeching NJ (2009). "Treatment of enteric fever". BMJ 338: b1159–b1159. doi:10.1136/bmj.b1159 . PMID 19493937 . ^ a b "Typhoid vaccines: WHO position paper" . Wkly. Epidemiol. Rec. 83 (6): 49–59. February 2008. PMID 18260212 . ^ Thaver D, Zaidi AK, Critchley JA et al. (2008). Bhutta, Zulfiqar A. ed. "Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever)". Cochrane Database Syst Rev 8 (4): CD004530. doi:10.1002/14651858.CD004530.pub3 . PMID 18843659 . 13.
^ Soe GB, Overturf GD (1987). "Treatment of typhoid fever and other systemic salmonelloses with cefotaxime, ceftriaxone, cefoperazone, and other newer cephalosporins". Rev Infect Dis (The University of Chicago Press) 9 (4): 719–36. doi:10.1093/clinids/9.4.719 . JSTOR 4454162 . PMID 3125577 . ^ Wallace MR, Yousif AA, Mahroos GA et al. (1993). "Ciprofloxacin versus ceftriaxone in the treatment of multiresistant typhoid fever". Eur J Clin Microbiol Infect Dis 12 (12): 907–910. doi:10.1007/BF01992163 . PMID 8187784 . 14.
15.
^ Dutta P, Mitra U, Dutta S et al. (2001). "Ceftriaxone therapy in ciprofloxacin treatment failure typhoid fever in children". Indian J Med Res 113: 210–
3. PMID 11816954 . 16.
^ Bhutta ZA, Khan IA, Molla AM (1994). "Therapy of multidrug­resistant typhoid fever with oral cefixime vs. intravenous ceftriaxone". Pediatr Infect Dis J 13 (11): 990–993. doi:10.1097/00006454­199411000­00010 . PMID 7845753 . 17.
^ Cao XT, Kneen R, Nguyen TA, Truong DL, White NJ, Parry CM (1999). "A comparative study of ofloxacin and cefixime for treatment of typhoid fever in children. The Dong Nai Pediatric Center Typhoid Study Group". Pediatr Infect Dis J 18 (3): 245–8. PMID 10093945 . ^ Effa EE, Bukirwa H (2008). Effa, Emmanuel E. ed. "Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever)". Cochrane Database of Systematic Reviews (1): CD006083. doi:10.1002/14651858.CD006083.pub2 . PMID 18843701 . ^ Cooke FJ, Wain J, Threlfall EJ (2006). "Fluoroquinolone resistance in Salmonella typhi (letter)". Brit Med J 333 (7563): 353–354. doi:10.1136/bmj.333.7563.353­b . PMC 1539082 . PMID 16902221 . ^ a b "Typhoid Fever" . World Health Organization. Retrieved 2007­08­28. 18.
19.
20.
21.
^ Papagrigorakis MJ, Yapijakis C, Synodinos PN, Baziotopoulou­Valavani E (2006). "DNA examination of ancient dental pulp incriminates typhoid fever as a probable cause of it can be must like 0 degrees or so.. of the Plague of Athens". Int J Infect Dis 10 (3): 206–214. 26.
27.
28.
doi:10.1016/j.ijid.2005.09.001 . PMID 16412683 . ^ Shapiro B, Rambaut A, Gilbert M (2006). "No proof that typhoid caused the Plague of Athens (a reply to Papagrigorakis et al.)". Int J Infect Dis 10 (4): 334–335. doi:10.1016/j.ijid.2006.02.006 . PMID 16730469 . ^ Byrne, Joseph Patrick (2008). Encyclopedia of Pestilence, Pandemics, and Plagues: A­M . ABC­CLIO. p. 190. ISBN 0313341028. ^ "Armies of pestilence: the effects of pandemics on history ". James Clarke & Co. (2004). p.191. ISBN 0­227­17240­X ^ "1900 Flow of Chicago River Reversed" . Chicago Timeline. Chicago Public Library. Archived from the original on 2007­03­07. Retrieved 2007­02­08. ^ "Nova: The Most Dangerous Woman in America" . ^ http://adbonline.anu.edu.au/biogs/A060109b.htm ^ "Straw for Silence" . The Spectator (F.C. Westley) 203. 1959. ISSN 0038­6952 . OCLC 1766325 . Retrieved March 16, 2011. 29.
^ Ravi Shankar, My Music, My Life (NY: Simon & Schuster, 1968), 69. 22.
23.
24.
25.
Further reading
[edit]
Easmon C (2005­04­01). "Typhoid fever and paratyphoid fever" . Travel Health. Retrieved 2008­10­05. Harrison NG. "Walter Reed and Typhoid Fever, 1897–1911" . Univ of Virginia. Retrieved 2008­10­05. Nicolson, Stuart (2008­06­26). "Typhoid left city (Aberdeen) 'under siege'" . BBC News. Retrieved 2008­10­05. O'Hara C (2006­01­26). "Typhoid Fever Led To The Fall Of Athens" . Elsevier. Retrieved 2008­10­05. External links
[edit]
CDC Disease Info typhoid_fever
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Infectious diseases ∙ Bacterial diseases: Proteobacterial G− (primarily A00–A79, 001–041, 080–109)
v ∙ d ∙ e
Typhus Rickettsia typhi (Murine typhus) ∙ Rickettsia prowazekii (Epidemic typhus, Brill–Zinsser disease, Flying squirrel typhus) Rickettsia rickettsii (Rocky Mountain spotted fever) ∙ Rickettsia conorii (
Boutonneuse fever) ∙ Rickettsia japonica (Japanese spotted fever) ∙ Rickettsia sibirica (
Rickettsiaceae/ (Rickettsioses) Rickettsiales Tick­borne Spotted North Asian tick typhus) ∙ Rickettsia australis (Queensland tick typhus) ∙ Rickettsia honei (
Flinders Island spotted fever) ∙ Rickettsia africae (African tick bite fever) ∙ Rickettsia parkeri (American tick bite fever) ∙ Rickettsia aeschlimannii (
fever Rickettsia aeschlimannii infection) α
Mite­borne Rickettsia akari (Rickettsialpox) ∙ Orientia tsutsugamushi (Scrub typhus) Flea­borne Rickettsia felis (Flea­borne spotted fever) Anaplasmataceae Ehrlichiosis: Anaplasma phagocytophilum (Human granulocytic anaplasmosis, Anaplasmosis) ∙ Ehrlichia chaffeensis (
Human monocytic ehrlichiosis) ∙ Ehrlichia ewingii (Ehrlichiosis ewingii infection) Brucellaceae Brucella abortus (Brucellosis) Rhizobiales Bartonellaceae Bartonellosis: Bartonella henselae (Cat scratch disease) ∙ Bartonella quintana (Trench fever) ∙ either henselae or quintana (Bacillary angiomatosis) ∙ Bartonella bacilliformis (Carrion's disease, Verruga peruana) M+ Neisseria meningitidis/meningococcus (Meningococcal disease, Waterhouse­Friderichsen syndrome, Meningococcal septicaemia) Neisseriales M­ Neisseria gonorrhoeae/gonococcus (Gonorrhea) ungrouped: Eikenella corrodens/Kingella kingae (HACEK) ∙ Chromobacterium violaceum (Chromobacteriosis infection) β
Burkholderiales Burkholderia pseudomallei (Melioidosis) ∙ Burkholderia mallei (Glanders) ∙ Burkholderia cepacia complex ∙ Bordetella pertussis/
Bordetella parapertussis (Pertussis) Klebsiella pneumoniae (Rhinoscleroma, Klebsiella pneumonia) ∙ Klebsiella granulomatis (Granuloma inguinale) ∙ Klebsiella oxytoca Lac+ Enterobacter aerogenes/Enterobacter cloacae Enterobacteriales (OX­) Escherichia coli: Enterotoxigenic ∙ Enteroinvasive ∙ Enterohemorrhagic ∙ O157:H7 ∙ O104:H4 (Hemolytic­uremic syndrome) Slow/weak Serratia marcescens (Serratia infection) ∙ Citrobacter koseri/Citrobacter freundii H2S+ Salmonella enterica (Typhoid fever, Paratyphoid fever, Salmonellosis) Lac­ Shigella dysenteriae/sonnei/flexneri/boydii (Shigellosis, Bacillary dysentery) ∙ Proteus mirabilis/
H2S­ Proteus vulgaris ∙ Yersinia pestis (Plague/Bubonic plague) ∙ Yersinia enterocolitica ∙ Yersinia pseudotuberculosis Haemophilus: H. influenzae (Haemophilus meningitis, Brazilian purpuric fever) ∙ H. ducreyi (Chancroid) H. parainfluenzae (HACEK) γ
Pasteurellales Pasteurella multocida (Pasteurellosis) ∙ Actinobacillus (Actinobacillosis) Aggregatibacter actinomycetemcomitans (HACEK) Legionellales Legionella pneumophila/Legionella longbeachae (Legionellosis) ∙ Coxiella burnetii (Q fever) Thiotrichales Francisella tularensis (Tularemia) Vibrionales Vibrio cholerae (Cholera) ∙ Vibrio vulnificus ∙ Vibrio parahaemolyticus ∙ Vibrio alginolyticus ∙ Plesiomonas shigelloides Pseudomonadales Pseudomonas aeruginosa (Pseudomonas infection) ∙ Moraxella catarrhalis ∙ Acinetobacter baumannii Xanthomonadales Stenotrophomonas maltophilia Cardiobacteriales Cardiobacterium hominis (HACEK) Aeromonadales Aeromonas hydrophila/Aeromonas veronii (Aeromonas infection) ε
Campylobacterales M: BAC Campylobacter jejuni (Campylobacteriosis, Guillain­Barré syndrome) ∙ Helicobacter pylori (Peptic ulcer, MALT lymphoma) ∙ Helicobacter cinaedi (Helicobacter cellulitis) bact (clas) gr+f/gr+a(t)/gr­p(c)/
drug(J1p, w , n, m, gr­o vacc) Categories: Intestinal infectious diseases | Conditions diagnosed by stool test | Waterborne diseases This page was last modified on 13 September 2011 at 06:05. Text is available under the Creative Commons Attribution­ShareAlike License; additional terms may apply. See Terms of use for details. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non­profit organization. Contact us Privacy policy About Wikipedia Disclaimers Mobile view