Kenya Outlet Report 2014
Transcription
Kenya Outlet Report 2014
Evidence for Malaria Medicines Policy ACTwatch Study Reference Document Republic of Kenya 2014 www.ACTwatch.info Copyright © Population Services International (PSI). All rights reserved. Released 23 February 2016 Suggested citation ACTwatch Group and Population Services Kenya (PSK). (2015). ACTwatch Study Reference Document: Republic of Kenya Outlet Survey 2014. Washington DC: PSI. Contact Dr. Megan Littrell ACTwatch Principal Investigator PSI | 1120 19th St NW Suit 600 Washington DC 20036 [email protected] Country contact Julius Ngigi Population Services International, ACTwatch Whitefield place, School Lane, Westlands P.O. Box 14355-00800, Nairobi Acknowledgements ACTwatch is funded by the Bill and Melinda Gates Foundation, UNITAID, and the UK Department for International Development. This study was implemented by Population Services International (PSI). ACTwatch Team Andrew Andrada Erick Auko Dr. Hana Bilak Dr. Desmond Chavasse Kevin Duff Gloria Kigo Tarryn Haslam Catharine Hurley Dr. Megan Littrell Julius Ngigi Ricki Orford Stephen Poyer Dr. Justin Rahariniaina Dr. Andria Rusk Julianna Smith Raymond Sudoi Kenya Malaria Control Unit Dr. Rebecca Kiptui Dr. Andrew Nyandigisi Kenya Pharmacy and Poisons Board Dr. Edward Abwao PS Kenya Dr. Anne Musuva Data Collection Management Ipsos: Samuel Muthoka Oscar Mutinda Hulda Kibera Anne Wanyingi James Ombasa Philemon Rono Lydia Wang’aya Regional Coordinators Questionnaire Traffic control John Maingi Rodgers Kegode Dickens Nyamogo Mary Omondi Gerald Musundi Pamela Kuya Quality Control Team Anthony Njeru Eunice Mokua Cidee Khaseke Edwin Ochieng Oluko Helen Kimanthi Shobby Ekasiba Hamida Omar Prudencial Bosibori Joan Chebet Sophie June Alfred Luchivia Nancy Makio Salome Omondi Purity Kimuru Coding Clerks Brenda Yonga Martha Abucherry Elizabeth Lango Elvis Matthews Joseph Ogeto Teresa Mumbi Ann Nyawira Kiai Samwel Kimani David Owino Edwin Otieno Gerald Njoroge Enumerators Sicily Kamuri Tom Ruto Amina Day Janet Obare Victor Nduku Rosemary Okoth Maureen Okumu Bevarlyne Kadenyi Linda Kwamboka Joshua Mwasia Bendetta Kathina Moses Angela Williams Munyan Ian Nickson Leiyan Monicah Ireri Laban Kibet Linda Norah Stephen Ouma Marlon Githua J.M. Makori Julie Sumba Jackline Nduta Harmony Momanyi Mary Lagat Betty Mumo Joram Mburu Paul Mboya Supervisors www.ACTwatch.info Page 1 Enumerators Innocent Omondi Brian Muchai Christine Rwanda Muthoni Anne Mugo Robert Muriithi Vincent Depaul Michael Omondi Faith Vutagua Jude Semut Mercy Ramogo Elijah Rogers Caroline Nelima Richard Njoroge Osborn Nyambare Edwin Nyarango Bernard Omondi W. Robert Kamau Agnes Karimi James Mutua Caroline Wangare Bridie Mwema Julius Kitela Stephen Oguna Diana Omolo Roselida Obiero James Nzioki Malachi Ayega Caroline Muli Samuel Rachuonyo Abraham Kisundi Daisy Nyambura Irene Mutisya Catherine Onchuati Collins Ouko Wambui Gitau Jacinta Kyusa Fredrick Aika Armstrong Andaje Caleb Bosire Sophia Ngaire James Kitheka Jane Wanza Teresa Moraa Francis Nyakundi William Chepkwony Jacinter Mbaika Brian Masika Ben Nduati Martin Mugendi Wendy Macharia Edith Mukhongo Sylvia Natasha Monicah Naisianoi Philemon Rono Kevin Onchama Naomi Nyarangi Nicholas Muriuki Florence Otieno www.ACTwatch.info Page 2 Table of Contents List of Tables ...................................................................................................................................................... 4 List of Figures ..................................................................................................................................................... 6 Definitions .......................................................................................................................................................... 9 Introduction ..................................................................................................................................................... 11 Summary of Methods and Data Collection ...................................................................................................... 12 Summary of Key Findings ................................................................................................................................. 14 Results Section A: Core Indicators ................................................................................................................... 38 Results Section B: Core Indicators across Urban/Rural Location .................................................................... 54 Results Section C: Core Indicators by Type of Public Health Facility ............................................................... 79 Results Section D: Core Indicators across Survey Round: 2010, 2011, 2014 .................................................. 83 Annex 1: ACTwatch Background .................................................................................................................... 100 Annex 2: Kenya Background .......................................................................................................................... 103 Annex 3: Outlet Survey Methods ................................................................................................................... 107 Annex 4: Sampled Locations .......................................................................................................................... 112 Annex 5: Detailed Sample Description .......................................................................................................... 117 Annex 6: Questionnaire ................................................................................................................................. 119 Annex 7: Antimalarial Reference ................................................................................................................... 137 Annex 8: RDT Reference ................................................................................................................................ 141 Annex 9. Sampling Weights ........................................................................................................................... 143 Annex 10: Indicator Definitions ..................................................................................................................... 145 Annex 11. Adult Equivalent Treatment Dose (AETD) .................................................................................... 153 Annex 12: Antimalarial Volumes.................................................................................................................... 155 www.ACTwatch.info Page 3 List of Tables Results Core Indicators Table S1: Key results, by outlet type - 2014.................................................................................................................... 14 Table A1: Availability of antimalarials, among all screened outlets, by outlet type....................................................... 38 Table A2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type..................... 40 Table A3: Antimalarial market composition ................................................................................................................... 42 Table A4a: Price of tablet formulation antimalarials, by outlet type ............................................................................. 43 Table A4b: Price of pre-packaged antimalarials, by outlet type ..................................................................................... 44 Table A5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type.......................... 45 Table A6: Malaria blood testing market composition .................................................................................................... 46 Table A7: Price of malaria blood testing, by outlet type ................................................................................................ 47 Table A8: Antimalarial market share .............................................................................................................................. 48 Table A9: Antimalarial market share across outlet type ................................................................................................ 49 Table A10: Malaria blood testing market share ............................................................................................................. 50 Table A11: Malaria blood testing market share, across outlet type............................................................................... 51 Table A12: Provider case management knowledge and practices, by outlet type......................................................... 52 Table A13: Provider antimalarial treatment knowledge and practices, by outlet type ................................................. 53 Results Across Urban/Rural Location Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location ......... 54 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location ............................................................................................................................................... 59 Table B3: Antimalarial market composition, across urban/rural location...................................................................... 64 Table B4a: Price of tablet formulation antimalarials, by outlet type, across urban/rural location ................................ 65 Table B4b: Price of pre-packaged antimalarials, by outlet type, across urban/rural location ....................................... 67 Table B5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type, across urban/rural location ............................................................................................................................................... 68 Table B7: Price of malaria blood testing, by outlet type, across urban/rural location ................................................... 69 Table B8a: Antimalarial market share, urban ................................................................................................................. 71 Table B8b: Antimalarial market share, rural ................................................................................................................... 72 Table B9a: Antimalarial market share across outlets, urban .......................................................................................... 73 Table B9b: Antimalarial market share across outlets, rural............................................................................................ 74 Table B12: Provider case management knowledge and practices, by outlet type, across urban/rural location ........... 75 Table B13: Provider antimalarial treatment knowledge and practices, by outlet type, across urban/rural location .... 77 Results by Type of Public Health Facility Table C1: Availability of antimalarials, among screened outlets, by type of public health facility ................................ 79 Table C2: Availability of antimalarials, among outlets stocking at least one antimalarial, by type of public health facility ..................................................................................................................................................................... 80 Table C5: Availability of malaria blood testing among antimalarial-stocking outlets*, by type of public health facility……………………………………………………………………………………………………………………………………………………………….81 Table C12: Provider antimalarial treatment knowledge and practices, by type of public health facility .............. 82 www.ACTwatch.info Page 4 Results Across Survey Round: 2010, 2011, 2014 Table D1: Availability of antimalarials, among all screened outlets, by outlet type, across survey round .................... 83 Table D2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type, across survey round ...................................................................................................................................................................... 87 Table D3: Antimalarial market composition, across survey round ................................................................................. 90 Table D4: Price of tablet formulation antimalarials in 2010 USD, by outlet type, across survey round ........................ 91 Table D5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type, across survey round ...................................................................................................................................................................... 94 Table D7: Price of malaria blood testing in 2010 USD, by outlet type, across survey round ......................................... 95 Table D8: Antimalarial market share, across survey round ............................................................................................ 96 Table D9: Antimalarial market share, across outlet type, across survey round ............................................................. 97 Table D12: Provider antimalarial treatment knowledge and practices, by outlet type, across survey round ............... 98 Annexes Table X1. Sampled locations ......................................................................................................................................... 112 Table X2: Detailed sample description ......................................................................................................................... 117 Table X3: Number of antimalarials audited .................................................................................................................. 137 Table X4: Quality-Assured (QA ACT) and Non-Quality Assured ACTs ........................................................................... 137 Table X5: Nationally Registered ACTs ........................................................................................................................... 139 Table X6: Severe Malaria Treatment ............................................................................................................................ 140 Table X7: Number of RDTs audited ............................................................................................................................... 141 Table X8: RDT Brand Names and Manufacturers* ....................................................................................................... 142 Table X9: Adult Equivalent Treatment Dose Definitions .............................................................................................. 154 Table X10: Antimalarial volumes, by outlet type .......................................................................................................... 155 www.ACTwatch.info Page 5 List of Figures Figure 1. Survey flow diagram, Kenya, 2014 ................................................................................................................... 13 Figure 2. Market composition: outlet type distribution, 2010-2014 .............................................................................. 16 Figure 3. Market composition: outlet type distribution, 2014, urban/rural .................................................................. 16 Figure 4. Percentage of outlets with at least one antimalarial in stock on the day of the survey, 2010-2014 .............. 17 Figure 5. Percentage of outlets with at least one antimalarial in stock on the day of the survey, 2014, urban/rural... 17 Figure 6. Percentage of antimalarial-stocking outlets with ACT in stock on the day of the survey, 2010-2014 ............ 18 Figure 7. Percentage of antimalarial-stocking outlets with ACT in stock on the day of the survey, 2014, urban/rural 18 Figure 8. Percentage of antimalarial-stocking outlets with quality-assured ACT in stock on the day of the survey, 2010-2014 .............................................................................................................................................................. 19 Figure 9. Percentage of antimalarial-stocking outlets with quality-assured ACT in stock on the day of the survey, 2014, urban/rural ................................................................................................................................................... 19 Figure 10. Percentage of antimalarial-stocking outlets with quality-assured ACT marked with the ‘green leaf’ logo in stock on the day of the survey, 2010-2014 ............................................................................................................ 20 Figure 11. Percentage of antimalarial-stocking outlets with quality-assured ACT marked with the ‘green leaf’ in stock on the day of the survey, 2014, urban/rural .......................................................................................................... 20 Figure 12. Percentage of antimalarial-stocking outlets with non-quality-assured ACT in stock on the day of the survey, 2010-2014 .............................................................................................................................................................. 21 Figure 13. Percentage of antimalarial-stocking outlets with non-quality-assured ACT in stock on the day of the survey, 2014, urban/rural ................................................................................................................................................... 21 Figure 14. Types of quality-assured ACT and non-quality-assured ACT found among public and private ..................... 22 sector outlets, 2014 ........................................................................................................................................................ 22 Figure 15. Percentage of antimalarial-stocking outlets with non-artemisinin therapy in stock on the day of the survey, 2010-2014 .............................................................................................................................................................. 23 Figure 16. Percentage of antimalarial-stocking outlets with non-artemisinin therapy in stock on the day of the survey, 2014, urban/rural ................................................................................................................................................... 23 Figure 17. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, 2010-2014 ............ 24 Figure 18. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, 2014, urban/rural . 24 Figure 19. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, by regions targeted or not targeted for IPTp, 2014................................................................................................................................ 25 Figure 20. Percentage of antimalarial-stocking outlets with any severe malaria treatment in stock on the day of the survey, 2010-2014 .................................................................................................................................................. 26 Figure 21. Percentage of antimalarial-stocking outlets with any severe malaria treatment in stock on the day of the survey, 2014, urban/rural....................................................................................................................................... 26 Figure 22. Antimalarial market share, 2010-2014 .......................................................................................................... 27 Figure 23. Antimalarial market share within sector, 2010-2014 .................................................................................... 27 Figure 24. Antimalarial market share, 2014.................................................................................................................... 28 Figure 25. Antimalarial market share, 2014, urban/rural ............................................................................................... 28 Figure 26. Percentage of antimalarial-stocking outlets with malaria blood testing available, 2010-2014 .................... 29 Figure 27. Percentage of antimalarial-stocking outlets with malaria blood testing available, 2014, urban/rural ......... 29 Figure 28. Percentage of antimalarial-stocking outlets with malaria microscopy available, 2010-2014 ....................... 30 Figure 29. Percentage of antimalarial-stocking outlets with malaria microscopy available, 2014, urban/rural............ 30 Figure 30. Percentage of antimalarial-stocking outlets with malaria RDTs, 2010-2014................................................. 31 Figure 31. Percentage of antimalarial-stocking outlets with malaria RDTs, 2014, urban/rural ..................................... 31 www.ACTwatch.info Page 6 Figure 32. Malaria blood testing market share, 2014 ..................................................................................................... 32 Figure 33. Malaria RDT market share by manufacturer, across sector, 2014 ................................................................ 32 Figure 34. Private sector median price of antimalarial adult equivalent treatment dosages (AETD), 2010-2014 .... 33 Figure 35. Private sector median price of QA ACT adult equivalent treatment dosages (AETD) with and .................... 33 without the ‘green leaf’ logo, 2010-2014 ....................................................................................................................... 33 Figure 36. Private sector median price of SP and quality-assured ACT adult equivalent treatment dosages (AETD) and pre-packaged pediatric quality-assured AL, 2014 .................................................................................................. 34 Figure 37. Private sector median price of SP and quality-assured ACT adult equivalent treatment dosages (AETD) and pre-packaged pediatric quality-assured AL, 2014, urban/rural ............................................................................. 34 Figure 38. Median private sector consumer prices for malaria RDT testing for adults and children 2014 .................... 35 Figure 39. Percentage of providers who correctly state the first-line treatment for uncomplicated malaria, 2010-2014 ................................................................................................................................................................................ 36 Figure 40. Percentage of providers who correctly state the first-line treatment for uncomplicated malaria, 2014, urban/rural ............................................................................................................................................................. 36 Figure 41. Percentage of providers who correctly state the first-line dosing regimen for uncomplicated malaria for a two-year old child, 2010-2014 ............................................................................................................................... 37 Figure 42. Percentage of providers who correctly state the first-line dosing regimen for uncomplicated malaria for a two-year old child, 2014, urban/rural .................................................................................................................... 37 www.ACTwatch.info Page 7 Acronyms ACT AETD AL AMFm ASAQ BMGF CHW DFID DHA PPQ DOMC EMA IM Artemisinin combination therapy Adult equivalent treatment dose Artemether lumefantrine Affordable Medicines Facility – malaria Artesunate amodiaquine The Bill and Melinda Gates Foundation Community Health Worker Department for International Development Dihydroartemisinin piperaquine Division of Malaria Control European Medicines Agency Intramuscular injection IPT IQR IRS ITN IV Kg KII KNBS KNMS KSH Mg MOH MOMS MOPHS NGO Pf PMI PPS QA RDT SP USAID USD WHO Intermittent Preventive Treatment Interquartile Range Indoor Residual Spraying Insecticide Treated Net Intravenous injection Kilogram Key Informant Interview Kenya National Bureau of Statistics Kenya National Medical Services Kenya Shillings Milligrams Ministry of Health Ministry of Medical Services Ministry of Public Health and Sanitation Non-governmental Organization Plasmodium falciparum President’s Malaria Initiative Probability proportional to size Quality-assured Rapid diagnostic test Sulfadoxine‐pyrimethamine United States Agency for International Development United States Dollar World Health Organization www.ACTwatch.info Page 8 Definitions Survey Methods Definitions Outlet Outlets eligible for inclusion in the study Cluster Censused location Booster Sample Any service delivery point or point of sale for commodities. Outlets are not restricted to stationary points of sale and may include mobile units or individuals. Outlets were administered a full questionnaire if they met at least one of three inclusion criteria: (1) had one or more antimalarials in stock at the time of the survey visit; (2) reportedly had one or more antimalarials in stock in the previous three months; or (3) provide malaria blood testing (microscopy or rapid diagnostic tests) but do not provide antimalarial treatment. Outlets not providing services to the general public (e.g. army and military clinics) were excluded from the study. The primary sampling unit, or cluster, for the outlet survey. It is an administrative unit determined by the Kenya National Bureau of Statistics (KNBS) that hosts a population size of approximately 10,000 to 15,000 inhabitants. These units are defined by political boundaries. In country, they were defined as locations. A locality where field teams conducted a full census of all outlets with the potential to sell antimalarials. A booster sample was collected by extending the primary sampling unit to a higher administrative unit for sampling certain outlet types. This extension achieves a larger sample size for specific outlets, allowing for estimates among key outlet types. In this survey, a booster sample was collected for public health facilities and pharmacies. The administrative unit for the census of public health facilities and pharmacies was extended beyond location to the Division level. See Annex 9 for a detailed description of the booster sampling methods. Malaria Product Indicator Definitions Antimalarial Dosing/treatment regimen Adult Equivalent Treatment Dose (AETD) Monotherapy Artemisinin and its derivatives Artemisinin-based Combination Therapy (ACT) Any medicine recognized by the WHO for the treatment of malaria. Medicines used solely for the prevention of malaria were excluded from analysis of key indicators in this report. The posology or timing and number of doses of an antimalarial used to treat malaria. This schedule often varies by patient weight. An AETD is the number of milligrams (mg) of an antimalarial drug required to treat a 60 kg adult (see Annex 11). An antimalarial medicine that has a single mode of action. This may be a medicine with a single active compound or a synergistic combination of two compounds with related mechanisms of action. Artemisinin is a plant extract or synthetic plant extract used in the treatment of malaria. The most common derivatives of artemisinin used to treat malaria are artemether, artesunate, and dihydroartemisinin. An antimalarial that combines artemisinin or one of its derivatives with an antimalarial or antimalarials of a different class. www.ACTwatch.info Page 9 Artemisinin monotherapy Oral artemisinin monotherapy Non-artemisinin therapy First-line treatment Second-line treatment Nationally registered ACTs Severe malaria treatment Quality-assured Artemisinin-Based Combination Therapies (QA ACTs) Quality-assured ACT with the “green leaf” logo, or “co-paid ACTs” Quality-assured RDT RDT with the “checkmark” logo 1 An antimalarial medicine that has a single active compound, where this active compound is artemisinin or one of its derivatives. Artemisinin or one of its derivatives in a dosage form with an oral route of administration. These include tablets, suspensions, and syrups and exclude suppositories and injections. An antimalarial medicine that does not contain artemisinin or any of its derivatives. The government recommended treatment for uncomplicated malaria. Kenya’s first‐line treatment is Artemether Lumefantrine. The government recommended second-line treatment for uncomplicated malaria. Kenya's second-line treatment for uncomplicated malaria is Dihydroartemisinin-Piperaquine. ACTs registered with a country’s national drug regulatory authority and permitted for sale or distribution in country. Each country determines its own criteria for placing a drug on its nationally registered listing. WHO recommends parenteral artesunate as first-line treatment in the management of severe falciparum malaria, with artemether or quinine injections as acceptable alternatives if parenteral artesunate is not available1. If complete treatment for severe malaria is not possible, patients with severe malaria should be given pre-referral treatment and referred immediately to an appropriate facility for further treatment. The following are options for prereferral treatment: rectal artesunate, injectable quinine, injectable artesunate and injectable artemether. QA ACTs are ACTs that comply with the Global Fund to Fight AIDS, Tuberculosis and Malaria’s Quality Assurance Policy. A QA ACT is any ACT that appeared on the Global Fund's indicative list of antimalarials meeting the Global Fund's quality assurance policy prior to data collection (see http://www.theglobalfund.org/en/procurement/quality/pharmaceutical/), or that previously had C-status in an earlier Global Fund quality assurance policy and was used in a program supplying subsidized ACTs. QA ACTs also include ACTs that have been granted regulatory approval by the European Medicines Agency (EMA) – specifically Eurartesim® and Pyramax®. The “green leaf” logo indicates that a quality-assured ACT was acquired through a co-payment mechanism administered by the Global Fund (Affordable Medicines Facility, malaria – or AMFm). These subsidized (co-paid) qualityassured ACTs were available to first-line buyers in Country in the public and private sector from 2010. QA RDTs are RDTs that comply with the Global Fund to Fight AIDS, Tuberculosis and Malaria’s Quality Assurance Policy. A QA RDT is any RDT that appeared on the Global Fund's indicative list of RDTs meeting the Global Fund's quality assurance policy prior to data collection (see http://www.theglobalfund.org/en/procurement/quality/diagnostics/#Quality). The “checkmark” logo indicates that a quality-assured RDT was acquired through a co-payment mechanism. These subsidized RDTs were available to private sector pharmacies and health facilities from August 2013. World Health Organization. (2010). Guidelines for the treatment of malaria, 2nd edition. Geneva: WHO. www.ACTwatch.info Page 10 Introduction This Kenya reference document is a detailed presentation of the 2014 national ACTwatch outlet survey (OS) conducted in Kenya. The 2014 OS follows previous survey rounds conducted as part of the Independent Evaluation of the Affordable Medicines Facility, malaria (AMFm) in 2010 and 2011. ACTwatch is a multi-country research project implemented by PSI (www.psi.org). Standardized tools and approaches are employed to provide comparable data across countries and over time. ACTwatch is designed to provide timely, relevant, and high quality antimalarial market evidence. The goal of providing this market evidence is to inform and monitor national and global policy, strategy, and funding decisions for improving malaria case management. The project was launched in 2008 with funding from the Bill and Melinda Gates Foundation (BMGF), and is currently funded through 2016 by the BMGF, UNITAID, and DFID. See Annex 1 for more information about the ACTwatch project. Antimalarial market monitoring in Kenya from 2010 to present has been implemented in the context of strategies designed and implemented to improve coverage of appropriate case management. These include: Scale up of quality-assured ACTs in the public and private sectors through mechanisms including the Global Fund co-payment mechanism piloted under the AMFm. The initial AMFm pilot period was 2010-2011 and copaid ACTs were delivered to first-line buyers in Kenya from 2010-2014 National efforts to improve availability of malaria blood testing and confirmatory testing prior to antimalarial treatment in both the public and private sectors. The 2014 OS was the third round of outlet surveys conducted in Kenya. This report presents trend lines with three data points: 1) the 2010 outlet survey; 2) the 2011 outlet survey; and 3) the most recent 2014 survey. These surveys are designed to monitor key antimalarial market indicators at national level and within urban/rural domains. ACTwatch outlet survey findings can inform ongoing monitoring, evaluation, and adjustment to policy, strategy, and funding decisions to strengthen malaria case management. Report notes This document is a complete reference for the 2015 outlet survey. Please see annexes for information about the study context, design, implementation and data analysis. Table numbers are consistent across all sections (not including the annex tables), and are reflective of table descriptions available in Annex 10 Grey text for data appearing in report tables indicates that the estimate provided was derived from a small sample size. Specifically, grey text is used to indicate point estimates derived from an n of less than 50 and median prices derived from an n of less than 5. Malaria testing and treatment prices are reported in US dollars. Price information is captured in local currency and converted to US dollars based on exchange rates available from www.oanda.com using the historical exchange rates tool. The average exchange rate over the entire data collection period is used for converting local currency captured during data collection to US dollars. www.ACTwatch.info Page 11 Summary of Methods and Data Collection A nationally-representative antimalarial outlet survey was conducted in Kenya between November 7, 2014 and December 22, 2014. A full description of research design and methods is provided in Annex 3. Briefly, a representative sample of locations was selected from urban and rural domains (see sampled locations in Annex 4). Within selected clusters, a census of all outlets with the potential to sell or distribute antimalarials and/or provide malaria blood testing was completed. The geographic area for sampling outlets was extended to the division level to achieve a sufficient sample size for estimating key indicators for important outlet types. This booster sampling strategy was used to obtain a sufficient sample size for indicator estimates within public health facilities and pharmacies. Outlets were screened to determine eligibility. Outlets eligible for the survey met at least one of three criteria: 1) one or more antimalarials were in stock on the day of the survey; 2) one or more antimalarials were in stock in the three months preceding the survey; and/or 3) malaria blood testing (microscopy or RDT) was available. Outlets that do not serve the general public (e.g. military facilities) were excluded from the study. The results of the census are summarized in Figure 1. A detailed sample summary is provided in Annex 5. A structured questionnaire was used to complete an audit of all antimalarials and RDTs as well as a provider interview (see Annex 6). See Annex 7 and Annex 8 for detailed summaries of antimalarials and RDTs audited. Double data entry was completed using Microsoft Access. All data cleaning and analysis was performed using Stata 13.1 (©StataCorp, College Station, TX). Data were weighted to account for variation in probability of outlet selection (see Annex 9), and standard error calculation reflected clustering of outlets at location and division levels. Standard indicators were constructed according to definitions applied across ACTwatch project countries (see Annex 10). www.ACTwatch.info Page 12 Figure 1. Survey flow diagram, Kenya, 2014 A Outlets enumerated* 14,127 Outlets not screened 1,451 B Outlets screened** 12,676 Respondent not available 95 Outlet closed at time of visit 324 Outlet closed permanently 798 Other 182 Refused 52 Respondent not available 6 Outlet closed at time of visit 3 Other 3 Refused 16 Outlets that did not meet screening criteria 10,199 C Outlets that met screening criteria 2,477 1 = 2,159 2 = 272 3 = 46 D Outlets not interviewed 28 Outlets interviewed*** 2,449 1 = 2,133 2= 272 3= 44 1: 2: 3: * Antimalarials in stock on day of visit Antimalarials reportedly in stock during the previous 3 months but not on the day of the visit Malaria blood testing available but no antimalarials in stock Identified as outlets with potential to sell or distribute antimalarials and/or provide malaria blood testing during the census or booster sampling ** Administered questions to assess current or recent (previous 3 months) availability of antimalarials and malaria blood testing (microscopy or rapid diagnostic test) *** A partial or complete interview was conducted with an outlet representative www.ACTwatch.info Page 13 Summary of Key Findings Table S1: Key results, by outlet type - 2014 Readiness for malaria case management Proportion of all screened outlets* with: Availability of malaria blood testing Availability of QA ACT Availability of QA ACT and malaria blood testing Availability of QA ACT, blood testing not available Availability of QA ACT, malaria blood testing, and provider correct knowledge of first line treatment Availability of any severe malaria treatment Readiness for malaria case management Proportion of antimalarial-stocking outlets with: Availability of malaria blood testing Availability of QA ACT Availability of QA ACT and malaria blood testing Availability of QA ACT, blood testing not available Availability of QA ACT, malaria blood testing, and provider correct knowledge of first line treatment Availability of any severe malaria treatment Public Health Facility % (95% CI) ALL Public / Not ForProfit1 % (95% CI) Private For-Profit Facility % (95% CI) N=485 N=1,096 92.7 (88.9, 95.2) 77.1 (72.6, 81.1) 72.7 (68.0, 77.0) 4.4 (2.3, 8.4) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private2 ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=453 N=503 N=572 N=9,950 N=11,580 N=12,676 19.7 (15.4, 24.9) 16.1 (12.2, 21.1) 14.4 (10.8, 19.0) 1.7 (1.2, 2.6) 67.5 (63.4, 71.3) 61.2 (57.2, 65.2) 46.9 (43.3, 50.6) 14.3 (12.2, 16.8) 20.4 (17.6, 23.6) 87.1 (84.8, 89.1) 19.5 (16.8, 22.6) 67.6 (63.7, 71.3) 15.7 (12.7, 19.3) 78.5 (76.0, 80.8) 13.8 (11.3, 16.8) 64.7 (61.5, 67.7) 0.0 0.8 (0.4, 1.3) 0.0 0.8 (0.4, 1.3) 3.5 (3.0, 4.1) 7.5 (6.7, 8.5) 2.6 (2.3, 3.1) 4.9 (4.3, 5.6) 4.7 (4.3, 5.2) 8.2 (7.4, 9.1) 3.5 (3.2, 3.9) 4.7 (4.1, 5.3) 71.9 (67.2, 76.2) 74.2 (69.5, 78.4) 14.2 (10.6, 18.8) 13.1 (9.9, 17.3) 44.6 (40.9, 48.3) 43.7 (40.3, 47.1) 19.4 (16.7, 22.5) 26.8 (22.3, 31.9) 12.7 (10.2, 15.7) 15.6 (12.1, 19.9) 0.0 0.0 (0.0, 0.1) 2.5 (2.1, 2.9) 2.7 (2.4, 3.1) 3.4 (3.0, 3.7) 3.5 (3.1, 3.8) N=457 N=517 N=342 N=487 N=535 N=252 N=1,616 N=2,133 93.8 (89.7, 96.4) 83.4 (79.5, 86.6) 78.6 (74.2, 82.5) 4.8 (2.4, 9.0) 87.4 (83.0, 90.8) 86.8 (83.1, 89.7) 77.4 (72.8, 81.4) 9.4 (6.5, 13.4) 76.0 (72.4, 79.2) 83.6 (80.7, 86.1) 64.0 (60.8, 67.2) 19.5 (16.7, 22.7) 20.9 (17.8, 24.4) 90.5 (88.8, 92.0) 20.3 (17.3, 23.7) 70.2 (66.9, 73.3) 16.4 (13.5, 19.9) 84.2 (81.8, 86.3) 14.8 (12.1, 18.0) 69.4 (66.0, 72.5) 0.0 26.2 (15.1, 41.6) 0.0 26.2 (15.1, 41.6) 28.5 (24.8, 32.4) 70.5 (64.4, 76.0) 24.6 (21.6, 27.9) 45.9 (41.7, 50.2) 35.6 (32.5, 38.9) 72.5 (66.9, 77.5) 31.0 (28.3, 33.8) 41.5 (38.0, 45.1) 77.8 (73.3, 81.7) 80.2 (75.6, 84.1) 76.5 (71.9, 80.5) 70.6 (63.2, 77.0) 60.8 (57.2, 64.4) 59.6 (55.3, 63.7) 20.2 (17.2, 23.6) 27.9 (23.5, 32.7) 13.6 (10.9, 16.9) 16.8 (13.0, 21.4) 0.0 1.2 (0.4, 3.1) 23.3 (20.3, 26.5) 25.2 (22.1, 28.6) 29.7 (27.0, 32.6) 30.7 (27.5, 34.2) www.ACTwatch.info Page 14 Table S1: Key results, by outlet type - 2014 Readiness for IPTp Proportion of outlets with SP available: Among all screened outlets* Among all screened outlets in endemic regions ** Readiness for IPTp Proportion of outlets with SP available: Among antimalarial-stocking outlets Among all screened outlets in endemic regions** Malaria market performance % QA ACT market share within outlet type^ Median price for one QA ACT adult equivalent treatment dose (AETD) Median price for one pre-packaged pediatric QA AL # Median price for an RDT ## Median price for malaria microscopy ## Public Health Facility N=485* N=140** 13.9 (9.7, 19.6) 49.2 (40.0, 58.5) N=457* N=138** 15.0 (10.5, 21.1) 49.7 (40.4, 59.0) ALL Public / Not ForProfit1 N=1,096* N=426** 3.1 (2.2, 4.2) 4.5 (3.1, 6.3) N=517* N=156** 16.5 (12.6, 21.3) 35.7 (27.3, 45.0) Private For-Profit Facility N=453* N=83** 18.1 (15.7, 20.8) 17.4 (13.0, 22.8) N=342* N=70** 24.7 (21.7, 28.0) 22.7 (17.3, 29.1) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private2 ALL Outlets N=503* N=487** 50.8 (47.5, 54.1) 68.0 (64.1, 71.5) N=487* N=81** 52.8 (49.4, 56.2) 69.6 (64.9, 74.0) N=572* N=535** 53.6 (50.1, 56.9) 56.3 (48.1, 64.1) N=535* N=123** 57.5 (54.0, 60.8) 60.2 (52.3, 67.7) N=9,950* N=252** 1.8 (1.2, 2.6) 1.3 (0.6, 2.9) N=252* N=64** 62.0 (48.0, 74.3) 40.7 (27.4, 55.4) N=11,580* N=1,616** 5.3 (4.7, 6.0) 4.9 (4.1, 6.0) N=1,616* N=338** 49.6 (45.5, 53.6) 47.1 (41.1, 53.2) N=12,676* N=2,133** 5.1 (4.6, 5.8) 4.9 (4.0, 5.9) N=2,133* N=494** 45.6 (41.9, 49.3) 45.2 (40.8, 49.8) 78.9 - 76.5 - - - - - 42.5 $1.13 [1.13-1.69] (449) $0.56 [0.45-0.90] (161) $1.13 [1.13-1.13] (53) $1.13 [1.13-1.13] (55) 52.7 $1.13 [1.13-1.69] (455) $0.56 [0.56-0.79] (131) $1.13 [1.13-1.13] (59) $1.13 [1.13-1.13] (30) 36.0 $1.13 [1.13-1.69] (41) $0.56 [0.56-1.13] (6) - 47.9 $1.33 [1.13-1.69] (1,184) $0.56 [0.56-1.13] (363) $1.13 [1.13-1.69] (245) $1.13 [0.56-1.13] (348) 51.4 - - 58.9 $1.41 [1.13-1.69] (239) $0.56 [0.56-1.13] (65) $1.13 [1.13-1.69] (133) $1.13 [0.56-1.13] (263) - 1 Inclusive of N= 58 screened and 43 antimalarial-stocking private not-for-profit outlets, and N= 553 screened and 17 antimalarial-stocking community health workers. 2 Inclusive of N= 102 screened and 0 antimalarial-stocking itinerant drug vendors. * The denominator includes 119 outlets that met screening criteria for a full interview but did not complete the interview (were not interviewed or completed a partial interview). ** Areas designated for the use of SP for the purposes of IPTp are limited to malaria endemic areas where transmission is intense throughout the year, and P. falciparum prevalence is historically greater than 20%. These areas include altitudes ranging from sea level in the coastal area to up to 1,300 meters around the Lake Victoria basin. Outlets with least one antimalarial in stock on the day of the survey. ^ Percent market volume (adult equivalent treatment dosages sold/distributed in the previous week) accounted for by quality-assured ACT (QA ACT) sale/distribution within the outlet type. # Pre-packaged QA AL for a 10kg child. Prices shown here are only for the private sector as price in public sector was free. ## Price of having test conducted, inclusive of RDT cost and consultation / service fees for a child under five. Prices shown here are only for the private sector as price in public sector was free. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 15 Figure 2. Market composition: outlet type distribution, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round Public Health Facility Community Health Worker 2010 N=1,471 11% Private Not For-Profit Facility 2011 N=1,348 3% 13% 3% 20% 31% 37% Private For-Profit Facility 3% 2014 N=1,501 1% 3% 10% 12% Registered Pharmacy 19% Unregistered Pharmacy 21% 3% General Retailer 33% 31% Itinerant Drug Vendor 30% 12% 3% The private sector accounted for more than 75% of antimalarial-stocking outlets at each survey round. However, the proportion of outlets accounted for by private for-profit health facilities and registered pharmacies increased over time (15% in 2010 versus 33% in 2014) relative to the proportion accounted for by unregistered pharmacies and general retail outlets (68% in 2010 versus 53% in 2014). Figure 3. Market composition: outlet type distribution, 2014, urban/rural Among all outlets with at least one antimalarial in stock Public Health Facility Community Health Worker Urban N=1,029 1% 3% 9% 6% Rural N=472 17% Private Not For-Profit Facility 3% Private For-Profit Facility 26% 40% 5% Registered Pharmacy Unregistered Pharmacy General Retailer Itinerant Drug Vendor 14% 41% 16% 18% 4% In urban and rural areas, approximately half of antimalarial-stocking outlets are informal private sector outlets. However, in urban areas these are primarily unregistered pharmacies (41%) while in rural areas general retailers accounted for 40% of all antimalarial-stocking outlets. One-quarter of antimalarial-stocking outlets in rural areas were public sector outlets as compared with 10% in urban areas, where private for-profit health facilities (26%) and registered pharmacies (16%) were more common than in rural areas (private for-profit facilities, 14%; registered pharmacies, 4%). www.ACTwatch.info Page 16 Figure 4. Percentage of outlets with at least one antimalarial in stock on the day of the survey, 20102014 Among all screened outlets, across survey round 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 2010 2011 2014 Public Health Facility Community Health Worker Private-Not-For-Profit Facility Private-For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer Availability of antimalarials in public health facilities, registered pharmacies and unregistered pharmacies remained high (nearly 90% or higher) over time. However, 2014 shows a drop from 2011 levels in the availability of antimalarials in private not for-profit and private for-profit facilities. For each of the surveys, the availability of antimalarials among CHWs has been low (<5%). Figure 5. Percentage of outlets with at least one antimalarial in stock on the day of the survey, 2014, urban/rural Among all screened outlets 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural Antimalarial availability was similar across urban and rural locations among private health facilities, registered pharmacies and unregistered pharmacies. Among public health facilities, 84% of all screened outlets in urban locations stocked antimalarials compared with 99% in rural locations. www.ACTwatch.info Page 17 Figure 6. Percentage of antimalarial-stocking outlets with ACT in stock on the day of the survey, 20102014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy ACT availability declined among antimalarial-stocking public health facilities between 2011 (97%) and 2014 (84%) and remained high among registered pharmacies over time (>90%). ACT availability among antimalarial-stock outlets increased over time among private for-profit facilities (2010, 58%; 2011, 84%; 2014, 93%), unregistered pharmacies (2010, 47%; 2011, 90%; 2014, 92%) and general retailers (2010, 0%; 2011, 24%; 2014, 27%). Figure 7. Percentage of antimalarial-stocking outlets with ACT in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural ACT availability was similar among antimalarial-stocking outlets in urban versus rural areas across outlet type. www.ACTwatch.info Page 18 Figure 8. Percentage of antimalarial-stocking outlets with quality-assured ACT in stock on the day of the survey, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Privat For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy QA ACT availability declined among antimalarial-stocking public health facilities between 2011 (97%) and 2014 (83%) and remained high among registered pharmacies between 2010 and 2014 (around 90%). QA ACT availability among antimalarialstock outlets increased between 2010 and 2011 and increases were maintained in 2014 among private for-profit facilities (2010, 37%; 2011, 78%; 2014, 84%), unregistered pharmacies (2010, 33%; 2011, 86%; 2014, 84%) and general retailers (2010, 0%; 2011, 23%; 2014, 26%). Figure 9. Percentage of antimalarial-stocking outlets with quality-assured ACT in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural QA ACT availability was similar among antimalarial-stocking outlets in urban versus rural areas across outlet type. www.ACTwatch.info Page 19 Figure 10. Percentage of antimalarial-stocking outlets with quality-assured ACT marked with the ‘green leaf’ logo in stock on the day of the survey, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy The availability of co‐paid QA ACT marked with the ‘green leaf’ logo among antimalarial-stocking outlets decreased among public health facilities between 2011 (69%) and 2014 (30%). However, availability remained high (>70%) between 2011 and 2014 among private for-profit health facilities, registered pharmacies and unregistered pharmacies. One-fifth of antimalarialstocking general retailers had QA ACT with the ‘green leaf’ logo in stock in 2011 (23%) and 2014 (21%). Figure 11. Percentage of antimalarial-stocking outlets with quality-assured ACT marked with the ‘green leaf’ in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural Availability of QA ACT with the ‘green leaf’ logo was similar among antimalarial-stocking outlets in urban versus rural areas across outlet type. www.ACTwatch.info Page 20 Figure 12. Percentage of antimalarial-stocking outlets with non-quality-assured ACT in stock on the day of the survey, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy The majority of antimalarial-stocking registered pharmacies had non-QA ACT in stock across survey rounds (>85%). Availability has increased over time among unregistered pharmacies from 29% in 2010 to 50% in 2014. Public health facilities, and general retailers generally did not have non-QA ACT in stock across survey rounds (<5%). Figure 13. Percentage of antimalarial-stocking outlets with non-quality-assured ACT in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Registered Pharmacy Facility Urban Unregistered Pharmacy General Retailer Rural Non-quality-assured ACT availability is higher among antimalarial-stocking urban as compared with rural outlets across private sector outlet types including private for-profit facilities (54% versus 33%), registered pharmacies (89% versus 69%), unregistered pharmacies (54% versus 33%) and general retailers (6% versus 1%). www.ACTwatch.info Page 21 Figure 14. Types of quality-assured ACT and non-quality-assured ACT found among public and private sector outlets, 2014 Among all ACT medicines audited, across sector, 2014 AL tablet QA ACT Public ASAQ tablet N=979 ASMQ tablet A PPQ tablet AS SP tablet DHA PPQ tablet AN tablet AL non-tablet 100% ASMQ non-tablet DHA PPQ non-tablet QA ACT Private N=2,245 Non-QA ACT Public N=62 14% 7% 32% 5% Non-QA ACT Private N=3,093 19 % 22 % 0% 8% 95% 36% 7% 32% 4% The majority of QA ACT products were audited in the private sector and all products audited in the public sector were AL tablets. A variety of non-QA ACT products were audited in the public and private sector and the majority of these were tablet formulations (>75%) including non-QA AL tablets (32% of public and 19% of private sector non-QA ACT) and non-QA DHA PPQ tablets (36% of public and 32% of private sector non-QA ACT). Common manufacturers of non-QA AL and DHA PPQ included Bliss GVS Pharmaceuticals (AL and DHA PPQ) and Beijing Holley-Cotec Pharmaceuticals (DHA PPQ). www.ACTwatch.info Page 22 Figure 15. Percentage of antimalarial-stocking outlets with non-artemisinin therapy in stock on the day of the survey, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy The availability of non-artemisinin therapy among antimalarial-stocking outlets has generally decreased since 2010 among public and private sector outlets. In 2014, availability was highest among general retailers (81%) and lowest among private for-profit facilities (52%). Figure 16. Percentage of antimalarial-stocking outlets with non-artemisinin therapy in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural Data trends suggest higher availability of non-artemisinin therapy among antimalarial-stocking outlets in rural versus urban areas among public and private sector outlet types. www.ACTwatch.info Page 23 Figure 17. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, 20102014 Among all outlets with at least one antimalarial in stock, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy SP is used for intermittent preventive treatment of malaria in pregnancy and should be dispensed during antenatal clinic visits. SP availability among antimalarial‐stocking health facilities has declined in recent years including among public health facilities (2010, 75%; 2011, 57%; 2014, 15%) and private for-profit facilities (2010, 43%, 2011, 42%; 2014 25%). More than half of antimalarialstocking outlets had SP available in 2014 among registered pharmacies (53%), unregistered pharmacies (58%) and general retailers (62%). Figure 18. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Registered Pharmacy Facility Urban Rural Unregistered Pharmacy General Retailer SP availability was similar among antimalarial-stocking public and private facilities and general retailers in urban versus rural areas. Data trends suggest higher availability among registered pharmacies and unregistered pharmacies located in rural versus urban areas. www.ACTwatch.info Page 24 Figure 19. Percentage of antimalarial-stocking outlets with SP in stock on the day of the survey, by regions targeted or not targeted for IPTp, 2014 Among all outlets with at least one antimalarial in stock, 2014 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Target Areas Non-Target Areas Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer Registered Pharmacy SP is used for intermittent preventive treatment of malaria in pregnancy and should be dispensed during antenatal clinic visits. In keeping with the WHO guidelines published in 2012 to limit SP use for IPTp to malaria-endemic areas, Kenya has designated areas for the use of SP for the purposes of IPTp to those where transmission is intense throughout the year, and P. falciparum prevalence is historically greater than 20%. These areas include altitudes ranging from sea level in the coastal area to up to 1,300 meters around the Lake Victoria basin. SP availability among antimalarial‐stocking health facilities in target areas is higher on average than availability in non-target areas. Half of the public health facilities in target areas had SP on-hand, compared to 2% of public health facilities in non-target areas. Similarly, SP availability in registered pharmacies was also higher in target areas compared to non-target areas (70% compared to 50%). Availability among private-for-profit facilities (23% and 25%) and unregistered pharmacies (60% and 57%) was nearly the same across target and non-target areas. www.ACTwatch.info Page 25 Figure 20. Percentage of antimalarial-stocking outlets with any severe malaria treatment in stock on the day of the survey, 2010-2014 Among all outlets with at least one antimalarial in stock, across survey round 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy Treatments for severe malaria include artesunate IV/IM, quinine IV/IM, artemether IV/IM, artemotil IV/IM, and artesunate suppositories. Severe malaria treatment availability among antimalarial-stocking outlets has remained similar over time among public health facilities (80% in 2014) and private for-profit health facilities (59% in 2014), and has declined between 2010 and 2014 among registered pharmacies (66%, 28%) and unregistered pharmacies (26%, 17%). Figure 21. Percentage of antimalarial-stocking outlets with any severe malaria treatment in stock on the day of the survey, 2014, urban/rural Among all outlets with at least one antimalarial in stock 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural Severe malaria treatment availability was higher among antimalarial-stocking unregistered pharmacies in rural (28%) versus urban areas (14%). Data trends suggest higher availability in rural versus urban registered pharmacies as well as urban versus rural private for-profit health facilities. www.ACTwatch.info Page 26 Percentage of total market volume Figure 22. Antimalarial market share, 2010-2014 Relative market volume (sale/distribution) of antimalarial AETDs, by sector and antimalarial class, across survey round 100 90 80 70 60 50 40 30 20 10 0 Public Private Public 2010 Private Public 2011 Private 2014 QAACT without 'green leaf' QAACT with 'green leaf' Non-QAACT SP Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy The antimalarial market share for the private sector has increased from 67% in 2010 and 63% in 2011 to 88% in 2014. QA ACT market share has increased from 26% in 2010 to 57% in 2011 and 51% in 2014. QA ACT marked with the ‘green leaf’ logo indicating co-payment accounted for half of all antimalarials distributed in 2011 dropping to 40% in 2014. Percentage of sector market volume Figure 23. Antimalarial market share within sector, 2010-2014 Relative market volume (sale/distribution) of antimalarial AETDs, within sector, by antimalarial class, across survey round 100 80 60 40 20 0 Public Private 2010 Public Private Public 2011 Private 2014 QAACT without 'green leaf' QAACT with 'green leaf' Non-QAACT SP Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy Approximately half of antimalarials distributed by the public sector were QA ACT in 2010 (54%) and 2011 (49%), increasing to 77% in 2014. In the private sector, QA ACT market share increased from 12% in 2010 to 62% in 2011 and dropped to 48% in 2014 in the context of increasing market share for non-QA ACT (2010, 11%; 2011, 7%; 2014, 20%). QA ACT with the ‘green leaf’ logo have accounted for the majority of QA ACT treatment distributed by the private sector over time and approximately half of QA ACTs distributed in the public sector in 2014. www.ACTwatch.info Page 27 Percentage of total market volume Figure 24. Antimalarial market share, 2014 Relative market volume (sale/distribution) of antimalarial AETDs, by outlet type and antimalarial class 100 90 80 70 60 50 40 30 20 10 0 Public Private Private for-Profit Health Facility Registered Pharmacy Unregistered Pharmacy General Retailer QAACT without 'green leaf' QAACT with 'green leaf' Non-QAACT SP Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy Private sector market share in 2014 (88%) is comprised of relative market share for unregistered pharmacies (31%), registered pharmacies (41%), private for‐profit health facilities (12%), and general retailers (5%). Percentage of total market volume Figure 25. Antimalarial market share, 2014, urban/rural Relative market volume (sale/distribution) of antimalarial AETDs, by sector and antimalarial class 100 90 80 70 60 50 40 30 20 10 0 Public Private Public Urban Private Rural QAACT without 'green leaf' QAACT with 'green leaf' Non-QAACT SP Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy The private sector distributed 92% of the antimalarials in urban locations as compared with 72% in rural locations. QA ACT accounted for half of antimalarials distributed in urban areas (50%) compared to 60% in rural areas. ‘Green leaf’ co‐paid QA ACT market share was higher in rural (40%) as compared with urban areas (11%). Non‐QA ACT accounted for 22% of antimalarials distributed in urban areas, compared with 5% in rural areas. www.ACTwatch.info Page 28 Figure 26. Percentage of antimalarial-stocking outlets with malaria blood testing available, 2010-2014 Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across survey round 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 2010 2011 2014 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer Registered Pharmacy Blood testing availability has increased among antimalarial-stocking health facilities including public health facilities (2010, 46%; 2011, 55%; 2014, 94%) and private not-for-profit facilities (2010, 53%; 2011, 45%; 2014, 74%). Availability has remained low over time among registered pharmacies (21% in 2014) and unregistered pharmacies (16% in 2014). Figure 27. Percentage of antimalarial-stocking outlets with malaria blood testing available, 2014, urban/rural Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Urban Registered Pharmacy Unregistered Pharmacy Rural Data trends suggest higher availability of malaria blood testing (RDT or microscopy) among antimalarial-stocking outlets in urban versus rural areas. www.ACTwatch.info Page 29 Figure 28. Percentage of antimalarial-stocking outlets with malaria microscopy available, 2010-2014 Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy Malaria microscopy availability has increased over time among antimalarial-stocking health facilities including public health facilities (2010, 41%; 2011, 42%; 2014, 61%) and private for-profit facilities (2010, 49%; 2011, 40%; 2014, 61%). Malaria microscopy is generally not available among registered pharmacies (8% in 2014) and unregistered pharmacies (6% in 2014). Figure 29. Percentage of antimalarial-stocking outlets with malaria microscopy available, 2014, urban/rural Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Urban Registered Pharmacy Unregistered Pharmacy Rural Malaria microscopy was more commonly available among urban versus rural public health facilities (71% versus 54%) and private for-profit health facilities (66% versus 45%). www.ACTwatch.info Page 30 Figure 30. Percentage of antimalarial-stocking outlets with malaria RDTs, 2010-2014 Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 2014 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer Registered Pharmacy Availability of malaria RDTs among antimalarial‐stocking outlets was less than 10% across all outlet types in 2010. By 2014, availability had increased significantly among public health facilities (68%) but remained relatively low among private for-profit facilities (29%), registered pharmacies (15%) and unregistered pharmacies (12%). Figure 31. Percentage of antimalarial-stocking outlets with malaria RDTs, 2014, urban/rural Among all outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across urban and rural zones 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Urban Registered Pharmacy Unregistered Pharmacy Rural RDT availability among antimalarial-stocking outlets was higher among public health facilities in rural (73%) versus urban areas (62%). Among private sector outlet types, data trends suggest higher availability in urban versus rural areas. www.ACTwatch.info Page 31 Figure 32. Malaria blood testing market share, 2014 Relative market volume (sale/distribution) of malaria blood testing using mRDTs and microscopy, by outlet type and type of test Percentage of total market volume 100 90 80 70 60 50 40 30 20 10 0 Public Private Private for-Profit Health Facility Microscopy Registered Pharmacy Unregistered Pharmacy General Retailer RDT More than half of all malaria blood tests were performed by public sector outlets (53%) and the majority of these tests were performed using microscopy. Malaria RDTs accounted for less than one-third of all tests performed (25%). Private for-profit facilities accounted for the majority of malaria blood testing performed by the private sector (42% of all tests performed). Percentage of within outlet market volume Figure 33. Malaria RDT market share by manufacturer, across sector, 2014 Relative market volume (sale/distribution) of malaria RDTs by manufacturer, within the public and private sector outlet types 100 90 80 70 60 50 40 30 20 10 0 Public ACCESS BIO INC. Private STANDARD DIAGNOSTICS INC. Private for-Profit Health Facility CTK BIOTECH INC. Registered Pharmacy Pharmacy Other Drug Store Unregistered Pharmacy Manufacturer not specified Among RDTs performed within public sector outlets, the majority (99%) were manufactured by Access Bio Inc. (99%). Within the private sector, Access Bio Inc. accounted for 64% of the market share followed by Standard Diagnostics (19%). www.ACTwatch.info Page 32 Figure 34. Private sector median price of antimalarial adult equivalent treatment dosages (AETD), 2010-2014 Among all SP and quality-assured ACT (tablet formulation only) available in the private sector, in 2010 US dollars to account for inflation, across survey round $10.00 $9.00 $8.00 2010 USD $7.00 $6.00 $5.00 $5.25 $4.61 $4.61 $4.00 $2.30 $3.00 $2.00 $0.46 $1.00 $0.52 $1.75 $0.66 $0.46 $0.00 2010 2011 Non QAACT 2014 Quality-Assured ACT SP The median private sector price for one adult equivalent treatment dose (AETD) of QA ACT decreased between 2010 and 2011, however, the price of QA ACT more than doubled between 2011 and 2014 and in 2014 remained more than 2.5 times more expensive than SP. The price of SP has remained similar over time and the price of non-QA ACT has increased over time and in 2014 non-QA ACT (tablet formulation) is three times as expensive as QA ACT. Figure 35. Private sector median price of QA ACT adult equivalent treatment dosages (AETD) with and without the ‘green leaf’ logo, 2010-2014 Among all quality-assured ACT (tablet formulation only) available in the private sector, in 2010 US dollars to account for inflation, across survey round $6.00 $5.00 2010 USD $4.00 $3.45 $3.00 $1.75 $2.00 $1.58 $1.15 $1.00 $0.46 $0.58 $0.00 2010 QAACT without "green leaf"logo 2011 2014 QAACT with "green leaf"logo The median private sector price for one AETD of QA ACT with the green leaf logo was similar to the price of QA ACT without the logo in 2011 and 2014. www.ACTwatch.info Page 33 Figure 36. Private sector median price of SP and quality-assured ACT adult equivalent treatment dosages (AETD) and pre-packaged pediatric quality-assured AL, 2014 Among all SP, QA ACT, and pre-packaged pediatric (treatment for a 2 year old child) QA AL (tablet formulation only) available in the private sector, in 2014 US Dollars $2.50 $2.00 Median price $1.69 $1.50 $1.50 $1.35 $1.35 $1.20 $1.00 $0.56 $0.68 $0.56 $0.50 $0.56 $0.56 $0.56 $0.56 $0.56 $0.56 $0.34 $0.00 SP AETD Private For-Profit Facility QA ACT AETD Registered Pharmacy Pediatric QA AL Unregistered Pharmacy General Retailer All private The private sector median price for AL pre-packaged for a two-year old child was $0.56 across all private sector outlet types. The median price of one QA ACT AETD was $1.50 in the private sector, ranging from a median of $1.13 among general retailers to $1.69 among private for-profit health facilities. Similarly the price of SP was least expensive among general retailers ($0.34) in comparison with registered pharmacies ($0.68). Figure 37. Private sector median price of SP and quality-assured ACT adult equivalent treatment dosages (AETD) and pre-packaged pediatric quality-assured AL, 2014, urban/rural Among all SP, QA ACT, and pre-packaged pediatric (treatment for a 2 year old child) QA AL (tablet formulation only) available in the private sector, in 2014 US Dollars $3.00 Median price $2.50 $2.00 $1.69 $1.50 $1.00 $1.13 $0.56 $0.56 $0.39 $0.56 $0.50 $0.00 SP AETD QA ACT AETD Urban Pediatric QA AL Rural The private sector median price for QA AL pre-packaged for a two-year old child was the same in urban and rural areas ($0.56). AETD median prices for SP and QA ACT were higher in urban versus rural areas. www.ACTwatch.info Page 34 Figure 38. Median private sector consumer prices for malaria RDT testing for adults and children 2014 Among all RDTs available within private for-profit health facilities, pharmacies and unregistered pharmacies, inclusive of consultation and service fees, in 2014 US dollars $3.00 $2.50 Median price $2.00 $1.50 $1.13 $1.13 $1.13 $1.13 $1.13 $1.13 $1.13 $1.13 $1.00 $0.50 $0.00 RDT - Adult Private-For-Profit Health Facility RDT - Child Registered Pharmacy Unregistered Pharmacy All Private The median private sector price for malaria blood testing with an RDT, inclusive of service and consultation fees, was $1.13 across all private sector outlet types for both adults and children under five. The median price for blood testing with malaria microscopy was also $1.13 across outlet types (data not shown). www.ACTwatch.info Page 35 Figure 39. Percentage of providers who correctly state the first-line treatment for uncomplicated malaria, 2010-2014 Among providers in outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across survey round 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy Across survey rounds, more than 90% of providers among antimalarial‐stocking public health facilities and registered pharmacies correctly stated the first‐line treatment for uncomplicated malaria (AL). Knowledge of first line treatment increased over time among providers at private for-profit health facilities (93% in 2014), unregistered pharmacies (91% in 2014) and among general retailers (29%). Figure 40. Percentage of providers who correctly state the first-line treatment for uncomplicated malaria, 2014, urban/rural Among providers in outlets with at least one antimalarial in stock on the day of the survey or within the past three months 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural First-line treatment knowledge was similar among providers in urban versus rural areas across outlet type. www.ACTwatch.info Page 36 Figure 41. Percentage of providers who correctly state the first-line dosing regimen for uncomplicated malaria for a two-year old child, 2010-2014 Among providers in outlets with at least one antimalarial in stock on the day of the survey or within the past three months, across survey round 100 90 Percentage of outlets 80 70 60 50 40 30 20 10 0 2010 2011 Public Health Facility Private For-Profit Facility Unregistered Pharmacy General Retailer 2014 Registered Pharmacy Overall, the percentage of providers who correctly state the first-line dosing regimen for uncomplicated malaria for a two-year old child rose across the survey rounds. It also rose within outlet types with the exception of registered pharmacies where it fell from 69% in 2010 to 64% in 2011. Figure 42. Percentage of providers who correctly state the first-line dosing regimen for uncomplicated malaria for a two-year old child, 2014, urban/rural Among providers in outlets with at least one antimalarial in stock on the day of the survey or within the past three months 100 Percentage of outlets 90 80 70 60 50 40 30 20 10 0 Public Health Facility Private For-Profit Facility Registered Pharmacy Urban Unregistered Pharmacy General Retailer Rural Knowledge of the dosing regimen for a two-year old child using the first-line treatment for uncomplicated malaria was similar among providers in urban versus rural areas across outlet type. www.ACTwatch.info Page 37 Results Section A: Core Indicators Table A1: Availability of antimalarials, among all screened outlets, by outlet type Community Health Worker Private NotFor-Profit Health Facility ALL Public % (95% CI) % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) N=485 N=553 N=58 N=1,096 92.5 (89.5, 94.7) 77.2 (72.7, 81.2) 77.2 (72.7, 81.2) 0.3 (0.1, 0.9) 0.0 1.9 (1.3, 3.0) 77.1 (72.6, 81.1) 77.1 (72.6, 81.1) 27.5 (22.1, 33.7) 64.6 (58.8, 69.9) 65.3 (59.7, 70.4) 39.5 (33.1, 46.2) 2.5 (1.7, 3.5) 75.8 (70.9, 80.2) 69.8 (64.2, 74.9) 2.6 (1.3, 5.0) 2.1 (0.9, 4.5) 2.1 (0.9, 4.5) 0.0 0.0 0.0 2.1 (0.9, 4.5) 2.1 (0.9, 4.5) 0.8 (0.4, 1.8) 1.5 (0.5, 4.3) 1.1 (0.4, 3.3) 1.8 (0.8, 4.3) 0.0 2.1 (0.9, 4.5) 0.5 (0.2, 1.2) 78.2 (68.7, 85.5) 75.6 (65.6, 83.5) 75.6 (65.6, 83.5) 0.0 0.0 18.2 (11.5, 27.5) 75.6 (65.6, 83.5) 75.6 (65.6, 83.5) 51.1 (36.5, 65.5) 43.2 (27.2, 60.7) 43.8 (28.2, 60.7) 63.2 (48.7, 75.6) 33.5 (18.6, 52.6) 73.0 (63.0, 81.2) 52.3 (37.9, 66.3) 18.6 (14.2, 24.0) 16.2 (12.2, 21.1) 16.2 (12.2, 21.1) 0.0 (0.0, 0.1) 0.0 1.5 (1.0, 2.3) 16.1 (12.2, 21.1) 16.1 (12.2, 21.1) 7.5 (5.1, 10.8) 12.0 (8.8, 16.0) 11.8 (8.6, 15.9) 10.6 (7.4, 14.9) 2.6 (1.3, 5.2) 15.8 (11.9, 20.6) 12.4 (9.3, 16.5) Public Health Facility % (95% CI) Proportion of outlets* stocking: Any antimalarial at the time of survey visit Any ACT Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) Artesunate Amodiaquine (ASAQ) DHA PPQ Quality Assured ACT (QA ACT) QA AL QA ACT with the ‘green leaf’ logo QA ACT without the ‘green leaf’ logo QA ACT – child (<5 years) QA ACT – adult Non-quality-assured ACT (non-QA ACT) Nationally Registered ACT Any non-artemisinin therapy Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=453 N=503 N=572 N=9,950 N=11,580 N=12,676 73.3 (68.5, 77.6) 67.9 (63.6, 71.8) 66.4 (62.2, 70.3) 2.1 (1.3, 3.3) 4.5 (3.2, 6.3) 22.9 (19.7, 26.5) 61.2 (57.2, 65.2) 60.6 (56.7, 64.4) 53.9 (50.0, 57.7) 14.9 (12.3, 18.1) 26.8 (23.6, 30.3) 50.0 (45.3, 54.7) 36.2 (33.0, 39.6) 65.6 (61.7, 69.2) 38.3 (33.8, 43.0) 96.3 (94.2, 97.7) 96.2 (94.1, 97.5) 94.2 (91.7, 96.0) 12.2 (8.8, 16.8) 16.5 (13.6, 19.9) 73.2 (67.1, 78.5) 87.1 (84.8, 89.1) 85.5 (83.1, 87.6) 82.7 (80.5, 84.8) 17.2 (14.4, 20.2) 44.0 (40.6, 47.5) 77.6 (74.8, 80.1) 84.4 (79.9, 88.1) 94.5 (92.4, 96.0) 62.0 (57.9, 65.9) 93.2 (91.7, 94.4) 85.8 (82.9, 88.3) 83.9 (81.1, 86.3) 3.8 (2.3, 6.3) 6.1 (4.8, 7.8) 34.2 (28.7, 40.3) 78.5 (76.0, 80.8) 77.9 (75.4, 80.2) 71.0 (67.5, 74.2) 16.3 (14.1, 18.8) 34.5 (31.0, 38.3) 66.7 (63.6, 69.7) 46.7 (40.3, 53.1) 83.0 (80.3, 85.4) 65.6 (62.2, 68.8) 2.9 (2.1, 4.0) 0.8 (0.4, 1.4) 0.8 (0.4, 1.4) 0.0 (0.0, 0.1) 0.0 0.1 (0.0, 0.1) 0.8 (0.4, 1.3) 0.8 (0.4, 1.3) 0.6 (0.4, 1.1) 0.2 (0.1, 0.4) 0.3 (0.2, 0.6) 0.5 (0.3, 0.9) 0.1 (0.0, 0.1) 0.8 (0.4, 1.3) 2.3 (1.6, 3.4) 10.7 (9.8, 11.7) 8.3 (7.3, 9.3) 8.1 (7.2, 9.1) 0.4 (0.3, 0.6) 0.6 (0.5, 0.8) 3.3 (2.8, 3.8) 7.5 (6.7, 8.5) 7.5 (6.7, 8.4) 6.7 (6.0, 7.6) 1.6 (1.4, 1.9) 3.4 (2.9, 3.9) 6.3 (5.5, 7.1) 4.5 (3.8, 5.2) 8.0 (7.1, 9.0) 7.2 (6.5, 8.1) 11.3 (10.4, 12.3) 8.8 (7.9, 9.8) 8.7 (7.8, 9.7) 0.4 (0.3, 0.6) 0.6 (0.5, 0.7) 3.1 (2.6, 3.7) 8.2 (7.4, 9.1) 8.1 (7.3, 9.0) 6.8 (6.0, 7.7) 2.4 (2.1, 2.8) 4.0 (3.5, 4.5) 6.6 (5.8, 7.4) 4.3 (3.7, 5.1) 8.6 (7.7, 9.5) 7.6 (6.9, 8.5) www.ACTwatch.info Page 38 Table A1: Availability of antimalarials, among all screened outlets, by outlet type Proportion of outlets* stocking: SulfadoxinePyrimethamine Oral Quinine Quinine IV/IM Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy Injectable artemether Injectable artesunate Injectable artemotil Any treatment for severe malaria Public Health Facility Community Health Worker Private NotFor-Profit Health Facility ALL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=485 N=553 N=58 N=1,096 N=453 N=503 N=572 N=9,950 N=11,580 N=12,676 13.9 (9.7, 19.6) 41.5 (36.1, 47.2) 54.2 (48.2, 60.1) 0.9 (0.4, 1.9) 0.0 50.8 (45.6, 56.0) 4.0 (2.6, 6.0) 49.6 (44.3, 54.9) 0.0 74.2 (69.5, 78.4) 0.5 (0.2, 1.2) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 - 13.9 (8.0, 23.0) 33.5 (19.1, 51.9) 41.9 (26.1, 59.5) 1.9 (0.3, 10.2) 0.0 48.4 (35.0, 62.0) 42.2 (28.3, 57.5) 11.2 (6.7, 18.2) 0.0 61.2 (48.2, 72.7) 3.1 (2.2, 4.2) 7.3 (5.1, 10.3) 9.4 (6.8, 12.8) 0.2 (0.1, 0.7) 0.0 9.4 (6.8, 12.9) 3.4 (1.8, 6.2) 6.7 (5.0, 9.0) 0.0 13.1 (9.9, 17.3) 18.1 (15.7, 20.8) 12.0 (9.6, 14.9) 22.7 (19.5, 26.2) 3.9 (2.5, 5.9) 0.1 (0.0, 0.3) 32.2 (29.0, 35.5) 28.2 (25.2, 31.4) 6.6 (5.1, 8.6) 1.5 (0.9, 2.3) 43.7 (40.3, 47.1) 50.8 (47.5, 54.1) 20.2 (16.5, 24.5) 11.2 (8.6, 14.3) 14.2 (12.0, 16.7) 0.0 24.3 (20.0, 29.2) 23.9 (19.5, 28.8) 4.3 (2.6, 7.0) 5.2 (3.2, 8.5) 26.8 (22.3, 31.9) 53.6 (50.1, 56.9) 24.6 (20.2, 29.5) 10.9 (7.6, 15.2) 8.4 (6.7, 10.6) 0.0 8.7 (6.6, 11.3) 8.6 (6.6, 11.1) 1.2 (0.6, 2.6) 0.9 (0.5, 1.6) 15.6 (12.1, 19.9) 1.8 (1.2, 2.6) 0.1 (0.0, 0.4) 0.0 (0.0, 0.1) 0.5 (0.2, 1.4) 0.0 0.0 (0.0, 0.1) 0.0 (0.0, 0.1) 0.0 0.0 0.0 (0.0, 0.1) 5.3 (4.7, 6.0) 1.9 (1.6, 2.2) 1.5 (1.3, 1.8) 1.1 (0.8, 1.7) 0.0 1.9 (1.6, 2.2) 1.7 (1.5, 2.0) 0.4 (0.3, 0.5) 0.2 (0.1, 0.2) 2.7 (2.4, 3.1) 5.1 (4.6, 5.8) 2.3 (2.0, 2.7) 2.1 (1.8, 2.4) 1.1 (0.7, 1.6) 0.0 2.5 (2.2, 2.8) 1.9 (1.6, 2.2) 0.8 (0.7, 1.0) 0.1 (0.1, 0.2) 3.5 (3.1, 3.8) * The denominator includes 119 outlets that met screening criteria for a full interview but did not complete the interview (were not interviewed or completed a partial interview). At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was the first-line treatment for uncomplicated malaria. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 39 Table A2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type Proportion of outlets* stocking: Any ACT Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) Artesunate Amodiaquine (ASAQ) DHA PPQ Quality Assured ACT (QA ACT) QA AL QA ACT with the ‘green leaf’ logo QA ACT without the ‘green leaf’ logo QA ACT – child (<5 years) QA ACT – adult Non-quality-assured ACT (non-QA ACT) Nationally Registered ACT Any non-artemisinin therapy SulfadoxinePyrimethamine Oral Quinine Quinine IV/IM Public Health Facility % (95% CI) Private Not-ForProfit Health Facility ALL Public 1 % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) N=457 N=43 N=517 83.5 (79.6, 86.8) 83.5 (79.6, 86.8) 0.3 (0.1, 1.0) 0.0 2.1 (1.4, 3.2) 83.4 (79.5, 86.6) 83.4 (79.5, 86.6) 29.8 (24.0, 36.3) 69.8 (64.0, 75.0) 70.6 (65.2, 75.4) 42.7 (36.0, 49.6) 2.7 (1.9, 3.8) 82.0 (77.4, 85.8) 75.5 (70.1, 80.2) 15.0 (10.5, 21.1) 44.9 (39.0, 50.9) 58.6 (52.6, 64.5) 96.7 (93.1, 98.5) 96.7 (93.1, 98.5) 0.0 0.0 23.2 (13.8, 36.4) 96.7 (93.1, 98.5) 96.7 (93.1, 98.5) 65.3 (47.1, 80.0) 55.2 (37.1, 72.0) 56.0 (38.3, 72.3) 80.8 (61.1, 91.8) 42.8 (24.3, 63.6) 93.4 (87.8, 96.5) 66.8 (52.0, 79.0) 17.8 (10.2, 29.3) 42.8 (25.7, 61.8) 53.6 (35.8, 70.5) 86.8 (83.2, 89.8) 86.8 (83.2, 89.8) 0.2 (0.1, 0.6) 0.0 8.0 (5.6, 11.2) 86.8 (83.1, 89.7) 86.8 (83.1, 89.7) 40.2 (33.5, 47.3) 64.2 (56.7, 71.2) 63.4 (56.7, 69.5) 56.9 (48.1, 65.2) 14.0 (7.9, 23.5) 85.0 (80.8, 88.4) 66.8 (59.4, 73.4) 16.5 (12.6, 21.3) 39.2 (31.9, 47.0) 50.5 (42.8, 58.2) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=342 N=487 N=535 N=252 N=1,616 N=2,133 92.6 (90.4, 94.3) 90.5 (88.4, 92.3) 2.8 (1.7, 4.7) 6.2 (4.6, 8.3) 31.3 (26.2, 36.9) 83.6 (80.7, 86.1) 82.7 (79.7, 85.3) 73.5 (69.1, 77.4) 20.4 (17.2, 23.9) 36.6 (32.2, 41.2) 68.2 (64.7, 71.6) 49.4 (44.8, 54.0) 89.4 (87.2, 91.3) 52.3 (47.5, 57.0) 24.7 (21.7, 28.0) 16.3 (13.3, 19.8) 30.9 (26.9, 35.3) 99.9 (99.7, 99.9) 97.8 (96.8, 98.5) 12.7 (9.1, 17.4) 17.2 (14.3, 20.4) 76.0 (70.6, 80.7) 90.5 (88.8, 92.0) 88.8 (87.0, 90.4) 85.9 (83.9, 87.7) 17.8 (15.1, 20.8) 45.7 (42.3, 49.2) 80.6 (78.4, 82.5) 87.7 (84.2, 90.5) 98.1 (96.9, 98.8) 64.3 (60.6, 67.9) 52.8 (49.4, 56.2) 21.0 (17.3, 25.2) 11.6 (9.0, 14.8) 92.1 (89.0, 94.3) 90.0 (87.1, 92.3) 4.1 (2.5, 6.8) 6.6 (5.1, 8.4) 36.7 (30.7, 43.3) 84.2 (81.8, 86.3) 83.6 (81.2, 85.8) 76.1 (72.6, 79.4) 17.5 (15.1, 20.2) 37.0 (33.3, 40.9) 71.6 (68.3, 74.7) 50.1 (43.2, 57.0) 89.0 (86.2, 91.4) 70.3 (66.9, 73.6) 57.5 (54.0, 60.8) 26.4 (21.7, 31.7) 11.7 (8.2, 16.4) 27.0 (15.7, 42.5) 27.0 (15.7, 42.5) 1.6 (0.5, 4.8) 0.0 2.0 (0.7, 5.2) 26.2 (15.1, 41.6) 26.2 (15.1, 41.6) 21.4 (12.9, 33.4) 5.5 (2.2, 13.3) 11.2 (5.8, 20.5) 18.9 (11.3, 29.7) 2.0 (0.7, 5.2) 26.0 (15.1, 41.0) 80.9 (68.6, 89.1) 62.0 (48.0, 74.3) 4.0 (1.1, 13.1) 0.4 (0.1, 2.1) 77.1 (69.8, 83.1) 75.6 (68.5, 81.4) 3.9 (2.8, 5.6) 5.8 (4.8, 7.1) 30.4 (25.8, 35.4) 70.5 (64.4, 76.0) 69.9 (63.8, 75.4) 63.0 (57.6, 68.2) 15.4 (13.3, 17.8) 31.4 (27.7, 35.4) 58.7 (53.5, 63.8) 41.6 (36.0, 47.5) 74.7 (67.8, 80.5) 67.6 (63.4, 71.6) 49.6 (45.5, 53.6) 17.8 (15.5, 20.4) 14.0 (11.7, 16.5) 78.3 (71.8, 83.7) 76.9 (70.6, 82.2) 3.5 (2.5, 4.9) 5.1 (4.2, 6.3) 27.7 (23.5, 32.3) 72.5 (66.9, 77.5) 72.0 (66.4, 76.9) 60.3 (55.5, 64.9) 21.3 (18.5, 24.5) 35.3 (31.5, 39.3) 58.5 (53.6, 63.2) 38.3 (33.1, 43.7) 75.9 (69.8, 81.1) 67.5 (63.7, 71.1) 45.6 (41.9, 49.3) 20.4 (17.8, 23.3) 18.4 (15.8, 21.4) www.ACTwatch.info Page 40 Table A2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type Proportion of outlets* stocking: Other non-artemisinin therapy Oral artemisinin monotherapy Non-oral artemisinin monotherapy Injectable artemether Injectable artesunate Injectable artemotil Any treatment for severe malaria 1 Public Health Facility % (95% CI) Private Not-ForProfit Health Facility ALL Public 1 % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) N=457 N=43 N=517 0.9 (0.4, 2.0) 0.0 54.9 (49.0, 60.7) 4.3 (2.8, 6.5) 53.6 (47.7, 59.5) 0.0 80.2 (75.6, 84.1) .42 (0.4, 12.9) 0.0 61.9 (46.9, 74.9) 54.0 (37.8, 69.3) 14.4 (8.3, 23.6) 0.0 78.2 (65.3, 87.2) 1.2 (0.4, 3.4) 0.0 50.7 (43.9, 57.6) 18.2 (11.2, 28.1) 36.2 (29.8, 43.2) 0.0 70.6 (63.2, 77.0) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=342 N=487 N=535 N=252 N=1,616 N=2,133 5.3 (3.5, 7.8) 0.2 (0.1, 0.4) 43.9 (39.8, 48.1) 38.4 (34.9, 42.1) 9.0 (6.9, 11.8) 2.0 (1.3, 3.3) 59.6 (55.3, 63.7) 14.7 (12.5, 17.3) 0.0 25.3 (21.1, 30.0) 24.8 (20.5, 29.6) 4.4 (2.7, 7.2) 5.4 (3.3, 8.8) 27.9 (23.5, 32.7) 9.1 (7.2, 11.3) 0.0 9.3 (7.1, 12.2) 9.2 (7.0, 11.9) 1.3 (0.6, 2.8) 1.0 (0.6, 1.7) 16.8 (13.0, 21.4) 17.9 (7.3, 37.6) 0.0 0.8 (0.3, 2.4) 0.8 (0.3, 2.4) 0.0 0.0 1.2 (0.4, 3.1) 10.7 (7.2, 15.7) 0.0 (0.0, 0.1) 17.8 (15.3, 20.6) 16.2 (14.0, 18.8) 3.3 (2.4, 4.5) 1.4 (0.9, 2.2) 25.2 (22.1, 28.6) 9.6 (6.4, 14.0) 0.0 (0.0, 0.1) 21.8 (19.3, 24.5) 16.5 (14.3, 18.9) 7.3 (6.1, 8.7) 1.3 (0.8, 1.9) 30.7 (27.5, 34.2) This includes 17 CHWs * Antimalarial-stocking outlets have at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. There were 67 antimalarial stocking outlets with partially completed interviews. The denominator includes only completed interviews. At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was the first-line treatment for uncomplicated malaria. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 41 Table A3: Antimalarial market composition Outlet type, among outlets with at least 1 antimalarial in stock on the day of the survey:* N=1,501 outlets Public Health Facility Community Health Worker Private NotFor-Profit Facility ALL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private % % % % % % % % % 9.5 1.3 3.3 14.0 21.4 11.8 33.0 19.8 86.0 (7.9, 11.4) (0.6, 2.5) (2.3, 4.7) (11.7, 16.8) (19.3, 23.6) (8.6, 16.0) (28.3, 38.0) (14.5, 26.4) (83.2, 88.3) * Excluding booster sample outlets. Outlets with at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 42 Table A4a: Price of tablet formulation antimalarials, by outlet type Private For-Profit Facility Median price of a tablet AETD*: Any ACT Artemether Lumefantrine (AL) Artesunate sulfadoxine pyrimethamine (ASSP) DHA PPQ Quality assured ACT (QA ACT) QA ACT with ‘green leaf’ logo QA ACT without the ‘green leaf’ logo QA AL Non-quality-assured ACT (non-QA ACT) Sulfadoxine-Pyrimethamine Quinine Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $2.25 $3.38 $2.25 $1.69 $2.25 [1.35-4.51] (655) [1.58-5.63] (2,115) [1.20-4.51] (1,432) [1.13-3.38] (84) [1.35-4.51] (4,286) $1.69 $1.69 $1.69 $1.35 $1.69 [1.13-3.15] (476) [1.13-2.82] (1,116) [1.13-2.25] (961) [1.13-1.69] (73) [1.13-2.25] (2,626) $5.63 $5.63 $5.07 $9.91 $5.63 [5.07-6.20] (12) [5.07-6.08] (76) [4.51-7.88] (19) [8.56-11.26] (2) [5.07-7.88] (109) $3.94 $4.28 $4.51 $5.07 $4.51 [3.38-5.07] (115) [3.38-5.63] (569) [3.94-5.63] (291) [3.38-5.63] (6) [3.38-5.63] (981) $1.69 $1.35 $1.35 $1.20 $1.50 [1.13-2.25] (433) $1.69 [1.13-2.25] [1.13-1.80] (889) $1.35 (360) [1.13-1.80] (818) $1.35 [1.13-1.80] (784) [1.13-1.80] [1.13-1.69] (69) $1.13 (725) [1.13-1.69] [1.13-2.25] (2,209) $1.50 (61) [1.13-2.25] (1,930) $1.69 $1.20 $1.35 $1.69 $1.35 [1.13-2.25] (71) [1.13-1.80] (105) [1.13-1.69] (92) [1.13-1.69] (8) [1.13-1.69] (276) $1.69 $1.35 $1.35 $1.20 $1.50 [1.13-2.25] (410) $4.51 [3.38-5.63] [1.13-1.80] (809) $4.82 (222) [3.38-9.08] [1.13-1.80] (781) $4.51 (1,226) [3.49-7.88] [1.13-1.69] (69) $5.63 (614) [3.38-11.26] [1.13-2.25] (2,069) $4.51 (15) [3.38-7.21] (2,077) $0.56 $0.68 $0.56 $0.34 $0.56 [0.45-1.13] (97) [0.56-1.69] (480) [0.56-1.13] (481) [0.34-0.45] (195) [0.39-0.90] (1,253) $4.73 $3.78 $4.26 $1.14 $4.26 (1) [2.37-4.73] (95) [2.37-7.10] (13) [3.31-4.73] (51) [2.37-4.73] (30) * AETD - adult equivalent treatment dose - is or the number of milligrams required to treat a 60kg adult (see Annex 11). Information provided by the respondent about price for a specific amount of antimalarial drug (e.g. price per tablet or price per specific package size) was converted to the price per AETD. At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was the first-line treatment for uncomplicated malaria. Figures in this table are derived using audited products with price information. The numbers of antimalarials captured in audit sheets with missing price information are as follows: 73 any ACT tablets, 47 artemether lumefantrine tablets, 2 artesunate sulfadoxine pyrimethamine tablets, 46 QA ACT tablets, 41 QA ACT AL tablets, 27 non-QA ACT tablets, 7 sulfadoxine pyrimethamine tablets, 1 quinine tablet. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 43 Table A4b: Price of pre-packaged antimalarials, by outlet type Private For-Profit Facility Median price of one pre-packaged therapy: Adult QA AL Pediatric QA AL * Registered Pharmacy Unregistered Pharmacy ALL Private General Retailer Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $1.58 $1.13 $1.13 $1.13 $1.13 [1.13-1.69] (240) [1.13-1.69] (452) [1.13-1.69] (460) [1.13-1.69] (42) [1.13-1.69] (1,194) $0.56 $0.56 $0.56 $0.56 $0.56 [0.56-1.13] (65) [0.45-0.90] (161) [0.56-0.79] (131) [0.56-1.13] (6) [0.56-1.13] (363) * Pediatric QA AL is the pre-packaged regimen appropriate for a 2 year old child. Figures in this table are derived using audited products with price information. The numbers of antimalarials captured in audit sheets with missing price information are as follows: 27 adult QA AL, 5 child QA AL. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 44 Table A5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type Proportion of outlets*** stocking Any malaria blood testing Microscopic blood tests Rapid diagnostic tests (RDTs) Checkmark RDTs 1 Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) N=471 N=573 94.0 ALL Public1 Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=375 N=490 N=556 N=405 N=1,826 N=2,399 73.0 74.3 21.0 16.1 0.0 25.2 31.6 (90.1, 96.4) N=470 (53.0, 86.7) N=571 (70.1, 78.0) N=375 (18.0, 24.3) N=490 (13.1, 19.7) N=555 N=403 (21.3, 29.5) N=1,823 (28.0, 35.4) N=2,394 60.9 47.3 61.1 8.2 5.7 0.0 17.4 21.5 (56.8, 64.9) N=470 (33.5, 61.6) N=571 (56.7, 65.4) N=375 (6.5, 10.4) N=490 (4.1, 7.7) N=555 N=403 (14.8, 20.5) N=1,823 (18.7, 24.4) N=2,394 68.2 51.7 29.2 15.0 12.3 0.0 12.6 17.8 (62.7, 73.3) N=469 (39.7, 63.5) N=570 (25.7, 33.0) N=374 (11.8, 18.9) N=490 (10.2, 14.8) N=555 N=403 (10.5, 15.0) N=1,822 (15.7, 20.1) N=2,392 0.1 0.3 0.5 1.3 0.0 0.0 0.2 0.2 (0.0, 0.2) (0.1, 1.3) (0.2, 1.1) (0.6, 3.1) - - (0.1, 0.4) (0.1, 0.4) This includes 52 CHWs and 50 Private not-For-Profit outlets * Blood testing availability is reported among outlets that either had antimalarials in stock on the day of the survey or reportedly stocked antimalarials in the previous 3 months. *** Results in this table are derived using responses captured among outlets with blood testing information. There were 6 antimalarial-stocking outlets that had missing information about both availability of microscopy and availability of RDTs. There were 18 antimalarial-stocking outlets that had partial information about blood testing availability. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 45 Table A6: Malaria blood testing market composition Outlet type, among outlets with malaria blood testing available on the day of the survey:* N=631 outlets Public Health Facility Community Health Worker Private NotFor-Profit Facility ALL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private % % % % % % % % % 22.4 4.5 8.0 34.9 47.2 4.6 13.3 - 65.1 (18.7, 26.6) (2.1, 9.1) (5.5, 11.4) (29.7, 40.4) (43.0, 51.4) (3.4, 6.2) (10.4, 16.9) - (59.6, 70.3) * Excluding booster sample outlets. Outlets with malaria blood testing available on the day of the survey, verified by presence of at least one RDT recorded in the RDT audit sheet and/or reported availability of malaria microscopy. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 46 Table A7: Price of malaria blood testing, by outlet type Private For-Profit Facility Total median price to consumers:* Registered Pharmacy Unregistered Pharmacy ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) Microscopic blood tests Adult Child under age five $1.13 $1.13 $1.13 $1.13 [0.56-1.13] (263) [1.13-1.13] (55) [1.13-1.13] (30) [0.56-1.13] (348) $1.13 $1.13 $1.13 $1.13 [0.56-1.13] (263) [1.13-1.13] (55) [1.13-1.13] (30) [0.56-1.13] (348) Rapid diagnostic tests (RDTs) Adult Child under five $1.13 $1.13 $1.13 $1.13 [1.13-1.69] (134) [1.13-1.13] (55) [1.13-1.69] (59) [1.13-1.69] (248) $1.13 $1.13 $1.13 $1.13 [1.13-1.69] (133) [1.13-1.13] (53) [1.13-1.13] (59) [1.13-1.69] (245) Median price excluding fees:** Rapid diagnostic tests (RDTs) Adult Child under five $0.17 $0.90 $0.68 $0.68 (1) [0.56-1.69] (13) [0.56-1.13] (21) [0.56-1.13] (35) $0.17 $0.68 $0.68 $0.68 (1) [0.56-1.69] (12) [0.56-1.13] (21) [0.56-1.13] (34) www.ACTwatch.info Page 47 Table A8: Antimalarial market share AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold / distributed:* 1. Any ACT Artemether Lumefantrine (AL) Public Health Facility TOTAL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private ANTI-MALARIAL TOTAL*** % % % % % % % % 7.5 10.0 9.6 27.4 20.8 2.3 60.0 70.0 21.0 17.8 2.1 49.2 58.8 7.4 9.6 8.3 DHA PPQ 0.0 0.4 0.8 4.8 2.2 0.2 7.9 8.3 Quality Assured ACT (QA ACT) 7.4 9.4 6.9 17.4 16.3 1.8 42.3 51.7 QA ACT with the ‘green leaf’ logo 3.8 4.8 5.5 14.1 14.1 1.4 35.1 39.9 QA ACT without the ‘green leaf’ logo 3.6 4.6 1.4 3.2 2.2 0.4 7.2 11.8 Non-quality-assured ACT 0.1 0.6 2.7 10.0 4.5 0.5 17.7 18.3 Nationally Registered ACT 7.2 9.6 8.7 21.7 18.1 2.0 50.5 60.0 2. Any non-artemisinin therapy 1.8 2.1 1.8 12.6 9.5 2.6 26.5 28.6 Sulfadoxine-Pyrimethamine 1.4 1.5 1.6 11.8 9.0 2.5 24.9 26.4 Oral Quinine 0.2 0.4 0.0 0.2 0.1 0.0 0.4 0.8 Quinine IV/IM 0.2 0.2 0.1 0.2 0.1 0.0 0.4 0.6 3. Oral artemisinin monotherapy 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.1 0.2 0.3 0.6 0.2 0.0 1.2 1.4 Injectable artesunate 0.1 0.1 0.1 0.0 0.1 0.0 0.2 0.3 Injectable artemether 0.0 0.1 0.3 0.6 0.1 0.0 1.0 1.1 Injectable artemotil 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.5 0.8 0.3 0.0 1.6 2.0 9.4 12.3 11.7 40.6 30.5 4.9 87.7 100.0 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** * A total of 35,645.28 AETDs were reportedly sold or distributed in the previous seven days. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. *** Row sum – market share for the specified antimalarial medicine. **** Column sum – market share for the specified outlet type. Categories 1 through 4 sum to 100% in the far-right column – antimalarial total column. A total of 6,651 antimalarials were audited. Of these, 325 audited antimalarials were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 48 Table A9: Antimalarial market share across outlet type AETDs sold or distributed in the previous week by antimalarial type as a percentage of all AETDs sold / distributed within each outlet type: * 1. Any ACT Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHA PPQ Quality Assured ACT (QA ACT) Public Health Facility % 79.5 % 81.2 Private For-Profit Facility % 81.7 79.0 78.2 71.3 51.7 58.2 42.6 56.1 0.0 0.5 0.0 2.9 0.6 6.9 0.6 11.7 0.3 7.3 0.2 3.1 0.5 9.0 TOTAL Public Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private % 67.4 % 68.1 % 46.7 % 68.4 78.9 76.6 58.9 42.8 53.3 36.0 48.2 QA ACT with the ‘green leaf’ logo 41.0 39.2 47.3 34.8 46.1 28.5 40.0 QA ACT without the ‘green leaf’ logo 37.9 37.3 11.6 8.0 7.2 7.5 8.2 Non-quality-assured ACT 0.6 4.7 22.7 24.6 14.9 10.7 20.2 Nationally Registered ACT 76.8 77.7 74.3 53.4 59.4 40.7 57.6 2. Any non-artemisinin therapy 19.4 17.0 15.3 31.1 31.1 53.3 30.2 Sulfadoxine-Pyrimethamine 15.4 12.1 13.4 29.2 29.4 51.8 28.4 Oral Quinine 1.9 3.1 0.4 0.5 0.4 0.0 0.4 Quinine IV/IM 1.8 1.6 0.9 0.5 0.3 0.0 0.5 3. Oral artemisinin monotherapy 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 1.1 1.7 2.9 1.5 0.7 0.0 1.3 Injectable artesunate 1.0 0.8 0.5 0.0 0.2 0.0 0.2 Injectable artemether 0.1 0.0 2.9 0.9 0.0 3.3 2.1 0.2 3.9 1.4 0.0 2.0 0.5 0.0 1.0 0.0 0.0 0.0 1.1 0.0 1.8 Injectable artemotil 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** 100 100 100 100 100 100 100 AETDs reportedly sold or distributed in the previous seven days: 2,883.8 public health facilities; 86.5 community health workers; 839.0 private not for-profit facilities; 4,077.4 private for-profit facilities; 15,788.6 registered pharmacies; 10,777.1 unregistered pharmacies; 1,192.9 general retailers. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. At the time of the 2014 Kenya ACTwatch outlet survey, artesunate amodiaquine was Kenya's first line treatment for uncomplicated malaria. Categories 1 through 4 sum to 100% within each column. A total of 6,651 antimalarials were audited. Of these, 325 audited antimalarials were not included in market share calculations due to due to incomplete or inconsistent information, including the following number of antimalarials by outlet type: 27 public health facilities; 1 community health worker; 1 private not for-profit facility; 80 private for-profit facilities; 61 registered pharmacies; 123 unregistered pharmacies, 32 general retailers. Source: ACTwatch Outlet Survey, Kenya, 2014. * www.ACTwatch.info Page 49 Table A10: Malaria blood testing market share Public Health Facility TOTAL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private BLOOD TEST TOTAL*** % % % % % % % % 1. Malaria microscopy 31.4 37.3 36.0 0.8 1.3 0.0 38.1 75.4 2. RDT 14.8 15.9 6.4 0.4 1.9 0.0 8.7 24.6 OUTLET TYPE TOTAL**** 46.2 53.3 42.3 1.2 3.2 0.0 46.7 100.0 Number of malaria blood tests provided in the previous week by outlet type and blood test type as a percentage of all blood tests provided:* * A total of 16,815 malaria microscopy tests and 4,536 RDTs were reportedly administered in the previous seven days. *** Row sum – market share for the specified type of blood testing medicine. **** Column sum – market share for the specified outlet type. Categories 1 and 2 sum to 100% in the far-right column – malaria blood testing total column. A total of 788 malaria blood tests were audited. Of these, 22 malaria microscopy tests and 8 RDTs were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 50 Table A11: Malaria blood testing market share, across outlet type Public Health Facility TOTAL Public / Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private BLOOD TEST TOTAL*** % % % % % % % % 1. Malaria microscopy 68.0 70.1 84.9 65.4 41.5 0.0 81.5 75.4 2. RDT 32.0 29.9 15.1 34.6 58.5 0.0 18.5 24.6 ACCESS BIO INC. 99.1 99.1 54.1 78.7 95.8 0.0 64.2 86.8 STANDARD DIAGNOSTICS INC. 0.5 0.5 25.8 2.4 1.1 0.0 19.3 7.2 CTK BIOTECH INC. 0.0 0.0 0.5 8.1 0.4 0.0 0.8 0.3 Other 0.3 0.4 14.4 10.8 2.8 0.0 11.7 4.4 Number of malaria blood tests provided in the previous week by blood test type as a percentage of all blood tests provided within each outlet type:* Total blood testing market Malaria RDT market Unknown 0.0 0.0 5.3 0.0 0.0 0.0 3.9 1.4 Checkmark RDT 0.0 0.0 0.7 6.0 0.0 0.0 0.8 0.3 * 21,351 malaria blood tests reportedly administered in the previous seven days: 9,250 public health facilities; 55 community health workers; 1,310 private not for-profit facilities; 9,712 private for-profit facilities; 340 registered pharmacies; 684 unregistered pharmacies. *** Categories 1 through 2 sum to 100% in within each column. The manufacturer information was missing for 8 RDTs audited. A total of 788 malaria blood tests were audited. Of these, 22 malaria microscopy tests and 8 RDTs were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 51 Table A12: Provider case management knowledge and practices, by outlet type Proportion of providers who: Would refer a 2 year old child with symptoms of severe malaria to a health facility Yes, would refer to health facility Would recommend that a client with a negative malaria blood test take an antimalarial Yes – sometimes Yes – always Circumstances cited for recommending antimalarial treatment to a client who tested negative for malaria:* Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) - N=59 - NA N=457 ALL Public 92.0 (79.5, 97.1) N=561 NA N=360 Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) N=490 N=550 N=403 N=1,443 N=1,502 90.6 84.9 88.4 87.0 87.3 (87.8, 92.9) (82.0, 87.4) (83.8, 91.8) (84.5, 89.1) (85.0, 89.4) N=429 N=457 N=143 N=1,389 N=1,950 21.3 21.8 30.6 30.0 30.0 11.2 27.1 26.1 (17.9, 25.2) (15.7, 29.3) (27.3, 34.2) (27.0, 33.3) (26.7, 33.5) (7.8, 15.8) (25.0, 29.2) (23.8, 28.6) 4.7 3.4 6.1 2.7 2.2 7.3 4.3 4.2 (3.2, 7.0) (2.4, 4.6) (4.1, 8.9) (1.9, 3.8) (1.2, 3.7) (3.0, 16.7) (3.2, 5.9) (3.1, 5.5) N=103 N=130 N=130 N=126 N=146 N=24 N=426 N=556 Patient has signs and symptoms of malaria. 98.6 94.9 88.6 90.6 86.2 70.7 86.1 87.4 (96.3, 99.4) (90.0, 97.5) (84.7, 91.6) (86.6, 93.5) (82.8, 89.0) (49.0, 85.8) (82.9, 88.7) (84.4, 89.9) Provider doesn't trust the test results. 19.4 16.3 7.6 11.6 15.8 24.4 13.1 13.6 (12.9, 28.1) (9.9, 25.8) (5.3, 10.7) (8.1, 16.4) (11.8, 21.0) (6.4, 60.6) (9.8, 17.3) (10.5, 17.4) 8.4 3.9 4.0 10.1 7.0 2.0 5.7 5.4 (5.0, 13.8) (2.1, 6.9) (2.3, 6.8) (7.3, 13.7) (5.1, 9.5) (0.6, 6.2) (4.2, 7.5) (4.1, 7.0) 81.1 74.4 87.6 83.8 77.9 89.3 83.3 82.0 (65.4, 90.7) (57.6, 86.2) (81.2, 92.0) (74.2, 90.4) (65.9, 86.6) (75.6, 95.8) (76.1, 88.7) (74.4, 87.7) When the patient asks for antimalarial treatment. Other (all other reasons) Provider questions were administered to one staff member working in each outlet eligible for a full interview (current/recent antimalarial-stocking outlets or outlets providing malaria blood testing). * No providers were missing information on circumstances for recommending antimalarials to clients who tested negative for malaria. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 52 Table A13: Provider antimalarial treatment knowledge and practices, by outlet type Proportion of providers who: Correctly state the national first-line treatment for uncomplicated malaria Correctly state the first-line dosing regimen for: An adult A two-year old child Public Health Facility % (95% CI) N=471 % (95% CI) N=573 Private For-Profit Facility % (95% CI) N=375 98.7 96.1 (97.5, 99.3) ALL Public 1 Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) N=492 % (95% CI) N=557 % (95% CI) N=408 % (95% CI) N=1,832 % (95% CI) N=2,405 92.8 96.2 91.0 29.3 71.5 74.8 (93.9, 97.5) (90.9, 94.3) (93.9, 97.6) (88.9, 92.7) (22.9, 36.6) (64.4, 77.7) (68.4, 80.3) 95.9 88.4 87.8 89.9 86.2 17.3 64.2 67.4 (92.9, 97.7) (84.1, 91.6) (85.7, 89.7) (87.9, 91.6) (83.8, 88.3) (12.9, 22.6) (57.0, 70.8) (61.0, 73.3) 87.8 79.1 73.0 81.1 73.9 10.1 53.2 56.7 (84.4, 90.6) (72.4, 84.4) (69.4, 76.3) (78.6, 83.3) (70.6, 76.9) (7.0, 14.3) (47.0, 59.3) (51.0, 62.2) 96.7 93.9 89.2 95.0 87.6 29.1 69.3 72.6 (94.6, 98.0) (90.6, 96.2) (86.7, 91.3) (93.3, 96.2) (85.7, 89.3) (19.7, 40.7) (61.2, 76.4) (65.3, 78.9) 94.7 91.6 87.3 96.3 85.6 21.9 65.8 69.3 (92.6, 96.3) (88.6, 93.8) (84.5, 89.6) (94.8, 97.4) (83.0, 87.8) (14.4, 31.8) (57.7, 73.2) (62.1, 75.7) 98.5 95.8 93.1 94.2 85.7 26.3 68.6 72.3 (96.3, 99.4) 98.0 (93.2, 97.4) 95.8 (91.2, 94.6) 87.7 (92.2, 95.7) 95.0 (83.3, 87.9) 82.8 (17.0, 38.3) 20.6 (60.2, 75.9) 64.4 (64.6, 78.8) 68.7 (95.7, 99.1) (92.6, 97.6) (85.3, 89.7) (92.8, 96.6) (79.6, 85.5) (13.5, 30.2) (56.5, 71.6) (61.4, 75.1) Report an ACT as the most effective antimalarial medicine for: Adults Children Report an ACT as the antimalarial he/she most commonly recommends for: Adults Children 1 This includes 52 community health workers and 50 private not-for profit outlets At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was Kenya's first line treatment for uncomplicated malaria. Numbers of providers (N) in this table are the total number of providers eligible for table indicators. 20 providers had missing information on the national first-line treatment, 19 on the first-line dosing regimen for adults and children, 18 on the most effective antimalarial medicine for adults and children and 19 on the most often recommended antimalarial for adults and children. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 53 Results Section B: Core Indicators across Urban/Rural Location Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location Proportion of outlets* stocking: Any antimalarial at the time of survey visit Urban Rural Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=182 Rural N=303 Urban N=34 Rural N=24 Urban N=509 Rural N=587 Urban N=351 Rural N=102 Urban N=454 Rural N=49 Urban N=469 Rural N=103 Urban N=6,342 Rural N=3,608 Urban N=7,715 Rural N=3,865 Urban N=8,224 Rural N=4,452 84.4 (78.4, 89.0) 98.5 (96.9, 99.2) 77.7 (69.4, 84.3) 78.7 (59.5, 90.3) 15.8 (11.5, 21.3) 21.2 (13.6, 31.6) 72.8 (66.9, 78.1) 74.9 (65.3, 82.6) 96.2 (93.9, 97.6) 97.8 (87.9, 99.6) 93.3 (91.8, 94.5) 93.0 (87.3, 96.2) 1.4 (1.0, 1.9) 5.3 (3.6, 7.8) 11.5 (10.5, 12.5) 9.3 (7.6, 11.4) 11.7 (10.7, 12.8) 10.5 (8.9, 12.5) 72.3 (64.5, 78.9) 80.9 (75.2, 85.6) 72.7 (63.8, 80.1) 78.7 (59.5, 90.3) 13.2 (9.4, 18.2) 18.9 (12.0, 28.5) 68.1 (63.2, 72.7) 67.1 (57.5, 75.3) 96.1 (93.8, 97.5) 97.8 (87.9, 99.6) 86.8 (83.9, 89.3) 81.7 (71.9, 88.6) 0.4 (0.3, 0.7) 1.3 (0.6, 3.0) 10.1 (9.1, 11.2) 5.1 (4.0, 6.5) 10.3 (9.3, 11.3) 6.5 (5.2, 8.1) 72.3 (64.5, 78.9) 80.9 (75.2, 85.6) 72.7 (63.8, 80.1) 78.7 (59.5, 90.3) 13.2 (9.4, 18.2) 18.9 (12.0, 28.5) 66.6 (61.9, 71.0) 65.4 (55.5, 74.2) 94.2 (91.4, 96.1) 94.9 (83.2, 98.6) 84.9 (82.1, 87.3) 79.8 (70.2, 86.8) 0.4 (0.3, 0.7) 1.3 (0.6, 3.0) 9.9 (8.9, 10.9) 5.0 (3.9, 6.4) 10.1 (9.1, 11.1) 6.4 (5.1, 8.0) 0.3 (0.1, 0.8) 0.3 (0.1, 1.9) 0.0 0.0 - 0.0 (0.0, 0.1) 0.0 (0.0, 0.3) 1.9 (1.0, 3.3) 2.7 (1.0, 7.0) 12.8 (9.1, 17.9) 3.8 (1.1, 12.4) 4.4 (2.5, 7.7) 1.4 (0.4, 4.7) 0.1 (0.0, 0.2) 0.0 - 0.6 (0.4, 0.9) 0.1 (0.1, 0.2) 0.6 (0.4, 0.8) 0.1 (0.1, 0.2) 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 5.3 (3.9, 7.4) 1.7 (0.5, 6.1) 17.2 (14.1, 20.9) 6.5 (2.6, 15.1) 6.2 (5.1, 7.5) 5.8 (1.9, 16.1) 0.0 0.0 - 0.9 (0.7, 1.0) 0.2 (0.1, 0.5) 0.8 (0.7, 1.0) 0.2 (0.1, 0.5) Any ACT Urban Rural Artemether Lumefantrine (AL) Urban Rural Artesunate Sulfadoxine Pyrimethamine (ASSP) Urban Rural Artesunate Amodiaquine (ASAQ) Urban Rural www.ACTwatch.info Page 54 Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location Proportion of outlets* stocking: DHAPPQ Urban Rural Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=182 Rural N=303 Urban N=34 Rural N=24 Urban N=509 Rural N=587 Urban N=351 Rural N=102 Urban N=454 Rural N=49 Urban N=469 Rural N=103 Urban N=6,342 Rural N=3,608 Urban N=7,715 Rural N=3,865 Urban N=8,224 Rural N=4,452 3.9 (2.5, 6.0) 0.5 (0.1, 2.8) 23.2 (15.0, 34.0) 12.9 (5.0, 29.5) 2.1 (1.3, 3.4) 0.9 (0.4, 2.1) 24.4 (20.6, 28.6) 17.9 (12.0, 25.8) 74.1 (67.5, 79.7) 61.0 (43.8, 75.8) 36.4 (30.0, 43.4) 25.4 (14.6, 40.5) 0.1 (0.0, 0.2) 0.0 (0.0, 0.2) 4.4 (3.8, 5.2) 1.2 (0.8, 1.8) 4.3 (3.7, 5.0) 1.2 (0.8, 1.7) 72.0 (64.3, 78.6) 80.9 (75.2, 85.6) 72.7 (63.8, 80.1) 78.7 (59.5, 90.3) 13.2 (9.4, 18.2) 18.9 (12.0, 28.5) 60.0 (55.4, 64.5) 65.4 (55.5, 74.2) 86.7 (84.3, 88.8) 93.3 (81.8, 97.7) 78.7 (76.5, 80.7) 77.8 (67.7, 85.4) 0.4 (0.2, 0.7) 1.3 (0.6, 3.0) 9.0 (8.2, 10.0) 4.9 (3.8, 6.3) 9.3 (8.4, 10.3) 6.3 (5.1, 7.9) 72.0 (64.3, 78.6) 80.9 (75.2, 85.6) 72.7 (63.8, 80.1) 78.7 (59.5, 90.3) 13.2 (9.4, 18.2) 18.9 (12.0, 28.5) 59.4 (54.9, 63.7) 64.9 (55.0, 73.6) 85.0 (82.4, 87.2) 93.3 (81.8, 97.7) 78.2 (75.9, 80.3) 76.9 (67.2, 84.4) 0.4 (0.2, 0.7) 1.3 (0.6, 3.0) 9.0 (8.1, 9.9) 4.9 (3.8, 6.3) 9.2 (8.3, 10.2) 6.3 (5.0, 7.9) 30.7 (22.5, 40.3) 25.2 (18.3, 33.7) 47.9 (39.1, 56.9) 54.5 (27.3, 79.2) 7.0 (4.6, 10.7) 7.9 (4.2, 14.3) 52.8 (48.9, 56.6) 57.7 (45.9, 68.7) 82.6 (80.3, 84.7) 84.1 (70.2, 92.2) 71.8 (68.8, 74.6) 67.7 (53.9, 78.9) 0.4 (0.2, 0.6) 1.0 (0.5, 2.3) 8.2 (7.4, 9.0) 4.2 (3.2, 5.6) 8.1 (7.3, 9.0) 4.6 (3.5, 6.0) 58.4 (51.7, 64.8) 69.1 31.3 (22.5, 41.8) 55.6 8.5 (6.0, 11.7) 15.2 16.2 (13.2, 19.7) 10.7 16.9 (14.0, 20.2) 21.3 15.3 (13.2, 17.8) 20.5 0.1 (0.0, 0.2) 0.3 2.0 (1.7, 2.3) 1.1 2.3 (2.1, 2.6) 2.5 (60.3, 76.7) (27.6, 80.4) (9.4, 23.7) (5.9, 18.5) (12.9, 33.1) (13.8, 29.4) (0.1, 1.1) (0.7, 1.5) (1.8, 3.5) 59.4 (49.7, 68.4) 69.7 (62.8, 75.7) 31.0 (23.0, 40.4) 57.1 (29.8, 80.7) 8.5 (5.8, 12.3) 14.8 (9.1, 23.3) 27.9 (25.0, 31.0) 23.2 (14.1, 35.7) 44.1 (40.5, 47.8) 42.7 (31.2, 55.0) 34.6 (31.6, 37.8) 34.1 (21.8, 49.1) 0.2 (0.1, 0.3) 0.6 (0.2, 1.5) 4.1 (3.7, 4.6) 2.0 (1.3, 3.1) 4.4 (4.0, 4.8) 3.3 (2.4, 4.6) Quality Assured ACT (QA ACT) Urban Rural QA AL Urban Rural QA ACT with the ‘green leaf’ logo Urban Rural QA ACT without the ‘green leaf’ logo Urban Rural QA ACT – child (<5 years) Urban Rural www.ACTwatch.info Page 55 Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location Proportion of outlets* stocking: QA ACT - adults Urban Rural Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=182 Rural N=303 Urban N=34 Rural N=24 Urban N=509 Rural N=587 Urban N=351 Rural N=102 Urban N=454 Rural N=49 Urban N=469 Rural N=103 Urban N=6,342 Rural N=3,608 Urban N=7,715 Rural N=3,865 Urban N=8,224 Rural N=4,452 37.9 (29.5, 47.1) 40.6 (31.4, 50.5) 66.1 (55.8, 75.0) 60.1 (32.6, 82.5) 9.1 (6.3, 13.0) 12.0 (6.6, 20.6) 49.5 (44.3, 54.8) 51.7 (40.0, 63.2) 77.0 (74.1, 79.7) 85.6 (71.2, 93.4) 67.4 (64.6, 70.1) 63.8 (52.8, 73.5) 0.3 (0.2, 0.6) 0.9 (0.4, 2.0) 7.7 (6.8, 8.7) 3.9 (3.0, 4.9) 7.8 (6.9, 8.7) 4.7 (3.7, 5.9) 4.7 (3.2, 6.8) 0.8 (0.2, 2.8) 23.2 (15.0, 34.0) 44.2 (18.1, 74.0) 2.2 (1.4, 3.5) 3.0 (0.9, 9.2) 39.5 (36.4, 42.8) 24.9 (18.5, 32.7) 85.6 (80.8, 89.4) 67.7 (50.7, 81.0) 50.6 (43.5, 57.6) 30.8 (19.3, 45.3) 0.1 (0.0, 0.2) 0.0 (0.0, 0.2) 6.1 (5.4, 7.0) 1.5 (1.1, 2.1) 5.9 (5.2, 6.8) 1.7 (1.2, 2.3) 72.1 (64.3, 78.7) 78.6 (71.8, 84.2) 70.2 (62.1, 77.2) 76.0 (56.6, 88.5) 13.0 (9.3, 17.9) 18.4 (11.7, 27.8) 65.3 (60.9, 69.5) 66.4 (57.2, 74.6) 94.4 (92.1, 96.0) 95.7 (77.2, 99.3) 83.9 (81.3, 86.2) 79.3 (69.6, 86.5) 0.4 (0.3, 0.7) 1.3 (0.6, 2.9) 9.7 (8.8, 10.7) 5.0 (3.9, 6.3) 9.9 (9.0, 10.9) 6.3 (5.1, 7.9) 60.9 (53.0, 68.2) 76.4 (69.0, 82.5) 43.7 (34.6, 53.2) 61.2 (35.5, 81.9) 10.5 (7.7, 14.1) 14.2 (8.7, 22.4) 36.8 (32.0, 41.8) 43.6 (31.6, 56.4) 61.0 (56.7, 65.2) 75.3 (62.8, 84.6) 63.7 (60.6, 66.7) 73.1 (61.1, 82.5) 1.0 (0.7, 1.5) 4.5 (2.9, 6.9) 7.2 (6.5, 8.1) 7.2 (5.6, 9.3) 7.4 (6.7, 8.2) 7.9 (6.4, 9.8) 12.4 (8.2, 18.3) 15.0 (8.7, 24.7) 18.4 (11.5, 28.2) 9.2 (2.2, 30.8) 3.6 (2.4, 5.3) 2.6 (1.6, 4.3) 17.4 (14.8, 20.3) 20.7 (14.7, 28.3) 50.2 (46.6, 53.7) 60.3 (50.4, 69.5) 51.9 (49.2, 54.6) 60.4 (46.5, 72.8) 0.8 (0.5, 1.4) 3.3 (2.1, 5.3) 5.3 (4.7, 6.0) 5.3 (4.0, 6.9) 5.2 (4.6, 5.9) 5.0 (3.8, 6.5) 35.0 (28.3, 42.3) 46.4 (38.4, 54.5) 22.0 (14.5, 32.1) 45.5 (20.8, 72.6) 5.3 (4.0, 7.0) 9.2 (5.2, 15.8) 11.4 (9.5, 13.6) 14.0 (6.6, 27.2) 19.5 (15.6, 24.1) 30.5 (19.1, 45.0) 20.6 (17.4, 24.3) 40.7 (27.4, 55.6) 0.0 (0.0, 0.1) 0.2 (0.1, 1.1) 2.1 (1.8, 2.4) 1.6 (1.1, 2.4) 2.2 (2.0, 2.6) 2.4 (1.7, 3.3) Non-quality-assured ACT (non-QA ACT) Urban Rural Nationally Registered ACT Urban Rural Any non-artemisinin therapy Urban Rural Sulfadoxine-Pyrimethamine Urban Rural Oral Quinine Urban Rural www.ACTwatch.info Page 56 Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location Proportion of outlets* stocking: Quinine IV/IM Urban Rural Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=182 Rural N=303 Urban N=34 Rural N=24 Urban N=509 Rural N=587 Urban N=351 Rural N=102 Urban N=454 Rural N=49 Urban N=469 Rural N=103 Urban N=6,342 Rural N=3,608 Urban N=7,715 Rural N=3,865 Urban N=8,224 Rural N=4,452 43.8 (36.0, 51.8) 62.0 (53.7, 69.6) 31.5 (22.5, 42.2) 52.7 (25.1, 78.8) 6.9 (5.0, 9.5) 11.7 (7.0, 19.0) 22.3 (19.4, 25.4) 24.0 (14.7, 36.6) 9.7 (7.3, 12.7) 31.6 (18.7, 48.3) 7.4 (4.9, 11.1) 24.8 (16.6, 35.4) 0.0 0.0 (0.0, 0.2) 1.6 (1.4, 1.9) 1.3 (0.9, 1.9) 1.9 (1.6, 2.3) 2.3 (1.8, 3.1) 2.0 (0.9, 4.2) 0.0 - 0.0 3.8 (0.6, 21.1) 0.2 (0.1, 0.5) 0.2 (0.0, 1.5) 4.6 (3.0, 7.2) 1.2 (0.2, 6.6) 14.6 (12.3, 17.4) 7.5 (2.6, 19.6) 9.0 (7.3, 11.0) 6.3 (2.5, 15.4) 0.2 (0.1, 0.3) 1.0 (0.3, 3.5) 1.1 (0.9, 1.4) 1.2 (0.4, 3.5) 1.1 (0.9, 1.3) 1.1 (0.4, 3.2) 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 0.1 (0.0, 0.4) 0.0 - 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 46.2 (40.9, 51.5) 54.2 (45.9, 62.3) 46.6 (38.1, 55.2) 50.4 (26.0, 74.5) 8.3 (6.0, 11.3) 10.5 (6.1, 17.5) 35.5 (32.6, 38.5) 20.8 (13.2, 31.2) 24.5 (19.8, 29.8) 22.3 (13.5, 34.5) 9.1 (6.7, 12.2) 7.2 (3.3, 14.9) 0.0 (0.0, 0.1) 0.0 - 2.6 (2.2, 3.0) 0.7 (0.5, 1.1) 2.9 (2.5, 3.3) 1.7 (1.3, 2.2) 6.4 (4.6, 8.9) 2.2 (0.7, 6.6) 34.4 (25.7, 44.3) 50.4 (26.0, 74.5) 3.2 (1.9, 5.3) 3.6 (1.2, 10.0) 31.2 (28.1, 34.5) 17.7 (12.4, 24.7) 24.0 (19.3, 29.4) 22.3 (13.5, 34.5) 8.9 (6.6, 11.8) 7.2 (3.3, 14.9) 0.0 (0.0, 0.1) 0.0 - 2.4 (2.1, 2.7) 0.6 (0.4, 1.0) 2.4 (2.1, 2.8) 0.9 (0.6, 1.4) 43.9 (38.6, 49.4) 53.8 (45.4, 62.1) 22.0 (13.5, 33.7) 0.0 - 6.2 (4.5, 8.5) 7.2 (4.4, 11.6) 7.6 (6.2, 9.4) 3.1 (0.5, 16.4) 4.4 (2.5, 7.4) 2.7 (0.5, 12.8) 1.6 (0.7, 3.4) 0.0 - 0.0 0.0 - 0.5 (0.4, 0.7) 0.1 (0.0, 0.4) 0.8 (0.7, 1.0) 0.8 (0.6, 1.1) Other non-artemisinin therapy Urban Rural Oral artemisinin monotherapy Urban Rural Non-oral artemisinin monotherapy Urban Rural Injectable artemether Urban Rural Injectable artesunate Urban Rural www.ACTwatch.info Page 57 Table B1: Availability of antimalarials, among all screened outlets, by outlet type, across urban/rural location Proportion of outlets* stocking: Injectable artemotil Urban Rural Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=182 Rural N=303 Urban N=34 Rural N=24 Urban N=509 Rural N=587 Urban N=351 Rural N=102 Urban N=454 Rural N=49 Urban N=469 Rural N=103 Urban N=6,342 Rural N=3,608 Urban N=7,715 Rural N=3,865 Urban N=8,224 Rural N=4,452 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 1.9 (1.2, 3.1) 0.0 - 5.4 (3.2, 9.1) 2.4 (0.4, 13.7) 1.1 (0.6, 2.1) 0.0 - 0.0 0.0 - 0.2 (0.1, 0.4) 0.0 - 0.2 (0.1, 0.4) 0.0 - 64.4 (58.5, 69.9) 81.4 (74.7, 86.6) 54.3 (44.6, 63.7) 68.3 (45.3, 84.9) 10.8 (7.9, 14.5) 15.3 (9.5, 23.8) 45.2 (42.5, 48.1) 38.3 (27.4, 50.6) 26.0 (21.3, 31.4) 38.1 (23.7, 54.9) 13.1 (9.8, 17.3) 25.9 (17.8, 36.1) 0.0 (0.0, 0.1) 0.0 (0.0, 0.2) 3.3 (2.9, 3.7) 1.7 (1.2, 2.3) 3.7 (3.3, 4.2) 3.0 (2.5, 3.7) Any treatment for severe malaria Urban Rural * The denominator includes 119 outlets that met screening criteria for a full interview but did not complete the interview (were not interviewed or completed a partial interview). ** The denominator includes 553 community health workers. Urban: 293 outlets. Rural: 260 outlets. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 58 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location Proportion of outlets* stocking: Public Health Facility % (95% CI) Private Not ForProfit Facility % (95% CI) ALL Public / NotFor-Profit** % (95% CI) Private For-Profit Facility % (95% CI) Urban N=160 Rural N=297 Urban N=27 Rural N=16 Urban N=190 Rural N=327 85.6 (80.0, 89.9) 82.2 (76.6, 86.6) 93.5 (87.7, 96.7) 100.0 - 85.6 (80.0, 89.9) 82.2 (76.6, 86.6) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=262 Rural N=80 Urban N=439 Rural N=48 Urban N=440 Rural N=95 Urban N=72 Rural N=180 Urban N=1,213 Rural N=403 Urban N=1,403 Rural N=730 83.8 (78.3, 88.2) 88.9 (83.9, 92.5) 93.5 (91.3, 95.2) 89.5 (82.0, 94.1) 99.9 (99.7, 99.9) 100.0 - 93.1 (90.2, 95.2) 87.9 (75.8, 94.4) 32.0 (19.4, 47.8) 25.0 (11.1, 47.1) 87.7 (84.1, 90.6) 54.4 (41.1, 67.1) 87.4 (83.8, 90.3) 61.5 (48.8, 72.7) 93.5 (87.7, 96.7) 100.0 - 83.8 (78.3, 88.2) 88.9 (83.9, 92.5) 91.5 (89.2, 93.3) 87.3 (80.1, 92.2) 97.9 (96.9, 98.6) 97.0 (84.0, 99.5) 91.0 (88.3, 93.1) 85.8 (74.5, 92.6) 32.0 (19.4, 47.8) 25.0 (11.1, 47.1) 85.9 (82.5, 88.7) 53.4 (40.3, 66.1) 85.7 (82.3, 88.5) 60.7 (48.1, 72.0) 0.3 (0.1, 0.9) 0.3 (0.1, 1.9) 0.0 0.0 - 0.2 (0.1, 0.5) 0.2 (0.0, 1.2) 2.5 (1.4, 4.7) 3.6 (1.4, 9.3) 13.3 (9.5, 18.5) 3.9 (1.1, 12.7) 4.7 (2.7, 8.2) 1.5 (0.5, 5.0) 5.6 (1.9, 15.2) 0.0 - 5.2 (3.5, 7.7) 1.1 (0.6, 2.4) 4.9 (3.3, 7.1) 1.0 (0.5, 1.9) 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 7.3 (5.6, 9.6) 2.3 (0.6, 8.2) 17.9 (14.9, 21.4) 6.7 (2.7, 15.4) 6.7 (5.5, 8.0) 6.2 (2.1, 17.1) 0.0 0.0 - 7.6 (6.6, 8.6) 2.1 (0.8, 5.3) 7.0 (6.1, 8.0) 1.7 (0.7, 4.2) 4.6 (3.1, 6.9) 0.5 29.8 (19.3, 43.1) 16.4 13.3 (9.7, 18.0) 4.3 33.5 (27.3, 40.4) 23.9 77.0 (71.1, 82.0) 62.4 39.0 (32.1, 46.5) 27.3 5.6 (1.9, 15.2) 0.5 38.6 (33.0, 44.6) 12.8 36.7 (31.4, 42.2) 11.1 (0.1, 2.9) (5.5, 39.8) (1.9, 9.1) (15.4, 35.2) (45.2, 76.9) (15.2, 44.1) (0.1, 3.2) (8.3, 19.4) (7.3, 16.5) 85.3 (79.6, 89.6) 82.2 (76.6, 86.6) 93.5 (87.7, 96.7) 100.0 - 83.7 (78.1, 88.0) 88.9 (83.9, 92.5) 82.4 (79.3, 85.2) 87.3 (80.1, 92.2) 90.1 (88.3, 91.7) 95.3 (83.9, 98.8) 84.3 (82.4, 86.1) 83.7 (72.8, 90.7) 29.2 (17.8, 44.1) 25.0 (11.1, 47.1) 78.8 (76.0, 81.3) 52.9 (39.9, 65.5) 79.1 (76.4, 81.6) 60.2 (47.8, 71.5) Any ACT Urban Rural Artemether Lumefantrine (AL) Urban Rural Artesunate Sulfadoxine Pyrimethamine (ASSP) Urban Rural Artesunate Amodiaquine (ASAQ) Urban Rural DHAPPQ Urban Rural Quality Assured ACT (QA ACT) Urban Rural www.ACTwatch.info Page 59 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location Proportion of outlets* stocking: Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=160 Rural N=297 Urban N=27 Rural N=16 Urban N=190 Rural N=327 Urban N=262 Rural N=80 Urban N=439 Rural N=48 Urban N=440 Rural N=95 Urban N=72 Rural N=180 Urban N=1,213 Rural N=403 Urban N=1,403 Rural N=730 85.3 (79.6, 89.6) 82.2 (76.6, 86.6) 93.5 (87.7, 96.7) 100.0 - 83.7 (78.1, 88.0) 88.9 (83.9, 92.5) 81.5 (78.2, 84.4) 86.6 (79.0, 91.7) 88.3 (86.4, 90.1) 95.3 (83.9, 98.8) 83.8 (81.7, 85.8) 82.7 (72.2, 89.8) 29.2 (17.8, 44.1) 25.0 (11.1, 47.1) 78.0 (75.3, 80.5) 52.5 (39.6, 65.0) 78.5 (75.7, 81.0) 59.9 (47.6, 71.1) 36.3 (27.5, 46.2) 25.6 (18.5, 34.3) 61.6 (50.5, 71.7) 69.2 (32.7, 91.2) 44.6 (36.5, 53.0) 37.2 (27.4, 48.2) 72.4 (67.6, 76.8) 77.1 (66.6, 85.0) 85.9 (83.9, 87.7) 86.0 (71.7, 93.7) 77.0 (74.0, 79.7) 72.7 (57.8, 83.9) 25.4 (15.3, 39.2) 19.7 (9.4, 36.9) 71.4 (68.5, 74.0) 45.2 (34.1, 56.7) 69.3 (66.3, 72.2) 43.5 (34.8, 52.7) 69.2 (62.4, 75.2) 70.2 (61.5, 77.6) 40.3 (29.3, 52.4) 70.6 (38.9, 90.0) 53.5 (46.4, 60.5) 71.7 (60.4, 80.8) 22.2 (19.1, 25.7) 14.3 (7.7, 25.0) 17.5 (14.7, 20.8) 21.8 (13.2, 33.6) 16.4 (14.1, 19.1) 22.1 (14.8, 31.6) 6.1 (3.3, 11.0) 5.3 (1.3, 18.5) 17.2 (15.6, 18.9) 11.5 (7.2, 17.8) 20.0 (18.6, 21.4) 23.8 (16.3, 33.4) 70.3 (60.9, 78.3) 70.7 (63.9, 76.8) 39.9 (29.6, 51.3) 72.6 (41.6, 90.8) 54.1 (46.0, 61.9) 69.8 (60.5, 77.8) 38.3 (34.2, 42.6) 31.0 (18.5, 47.0) 45.9 (42.2, 49.6) 43.6 (32.3, 55.7) 37.1 (34.0, 40.4) 36.7 (23.4, 52.3) 13.2 (8.3, 20.5) 10.4 (3.9, 24.9) 36.1 (34.2, 38.0) 21.5 (13.4, 32.6) 37.4 (35.6, 39.3) 31.4 (22.1, 42.4) 44.9 (36.2, 54.0) 41.2 (31.9, 51.2) 85.0 (75.4, 91.3) 76.4 (37.2, 94.6) 57.8 (50.9, 64.5) 56.3 (42.0, 69.6) 68.0 (64.8, 71.1) 69.0 (56.7, 79.0) 80.1 (77.9, 82.1) 87.5 (72.6, 94.8) 72.3 (69.4, 75.0) 68.6 (56.2, 78.8) 22.6 (13.1, 36.2) 17.3 (8.2, 32.7) 66.8 (63.4, 70.1) 41.3 (32.6, 50.5) 66.1 (62.7, 69.4) 44.4 (35.7, 53.3) 5.6 (3.9, 7.9) 0.8 (0.2, 2.8) 29.8 (19.3, 43.1) 56.2 (22.6, 84.9) 13.8 (10.3, 18.4) 14.1 (5.3, 32.2) 54.3 (49.2, 59.2) 33.2 (24.4, 43.5) 89.0 (85.5, 91.8) 69.2 (52.5, 82.0) 54.2 (46.6, 61.6) 33.2 (20.1, 49.4) 5.6 (1.9, 15.2) 0.5 (0.1, 3.2) 53.5 (48.3, 58.6) 16.2 (10.7, 23.8) 50.4 (45.3, 55.5) 15.8 (11.0, 22.0) QA AL Urban Rural QA ACT with the ‘green leaf’ logo Urban Rural QA ACT without the ‘green leaf’ logo Urban Rural QA ACT – child (<5 years) Urban Rural QA ACT - adults Urban Rural Non-quality-assured ACT (non-QA ACT) Urban Rural www.ACTwatch.info Page 60 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location Proportion of outlets* stocking: Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=160 Rural N=297 Urban N=27 Rural N=16 Urban N=190 Rural N=327 Urban N=262 Rural N=80 Urban N=439 Rural N=48 Urban N=440 Rural N=95 Urban N=72 Rural N=180 Urban N=1,213 Rural N=403 Urban N=1,403 Rural N=730 85.4 (79.7, 89.7) 79.8 (73.0, 85.3) 90.3 (84.5, 94.1) 96.5 (81.5, 99.4) 82.6 (77.2, 86.9) 86.6 (80.4, 91.1) 89.7 (87.4, 91.6) 88.7 (80.9, 93.6) 98.1 (96.9, 98.9) 97.8 (87.2, 99.7) 90.0 (87.4, 92.1) 85.2 (73.4, 92.4) 29.7 (18.3, 44.2) 24.5 (10.9, 46.1) 84.6 (81.3, 87.4) 53.3 (40.4, 65.8) 84.5 (81.1, 87.3) 60.1 (47.8, 71.2) 72.1 (64.0, 79.0) 77.6 (70.2, 83.6) 56.3 (45.1, 66.8) 77.8 (51.5, 92.0) 66.6 (59.4, 73.1) 66.9 (55.0, 77.0) 50.5 (45.8, 55.2) 58.2 (44.0, 71.2) 63.4 (59.4, 67.2) 76.9 (64.6, 85.9) 68.3 (65.0, 71.4) 78.6 (66.7, 87.1) 74.0 (58.9, 85.0) 83.7 (65.9, 93.2) 63.0 (59.8, 66.2) 77.5 (67.1, 85.2) 63.3 (60.2, 66.3) 75.3 (66.9, 82.2) 14.7 (10.0, 21.1) 15.2 (8.8, 25.0) 23.7 (15.1, 35.2) 11.7 (2.8, 37.4) 22.5 (17.8, 28.1) 12.3 (7.3, 20.0) 23.8 (20.9, 27.0) 27.6 (19.2, 37.9) 52.1 (48.5, 55.8) 61.6 (51.4, 71.0) 55.6 (53.0, 58.2) 64.9 (50.3, 77.2) 60.1 (44.2, 74.1) 62.8 (43.5, 78.8) 46.3 (43.5, 49.1) 56.6 (45.6, 67.0) 44.4 (41.9, 47.1) 47.6 (38.3, 57.1) 41.5 (33.5, 49.9) 47.1 (39.0, 55.4) 28.4 (18.9, 40.2) 57.8 (29.0, 82.1) 33.6 (27.6, 40.2) 43.2 (31.9, 55.1) 15.6 (13.6, 17.9) 18.7 (9.1, 34.5) 20.2 (16.3, 24.8) 31.2 (19.7, 45.7) 22.1 (18.6, 26.1) 43.8 (30.1, 58.5) 2.8 (1.0, 7.8) 4.5 (0.9, 19.5) 17.9 (16.1, 20.0) 17.5 (11.7, 25.4) 19.1 (17.3, 21.2) 22.8 (16.4, 30.7) 51.8 (43.5, 60.1) 62.9 (54.5, 70.6) 40.6 (29.3, 53.0) 67.0 (36.5, 87.7) 43.8 (37.4, 50.5) 55.2 (43.1, 66.7) 30.6 (26.7, 34.8) 32.0 (20.6, 46.1) 10.1 (7.7, 13.2) 32.3 (19.2, 48.9) 8.0 (5.3, 11.9) 26.7 (18.1, 37.5) 0.0 0.5 (0.1, 3.2) 14.1 (11.9, 16.6) 13.7 (8.8, 20.6) 16.4 (13.9, 19.3) 22.1 (16.4, 29.1) 2.4 (1.1, 4.9) 0.0 - 0.0 4.8 (0.7, 26.6) 1.3 (0.6, 2.8) 1.2 (0.2, 6.6) 6.4 (4.3, 9.3) 1.6 (0.3, 8.9) 15.2 (12.8, 18.0) 7.6 (2.7, 20.1) 9.6 (7.9, 11.7) 6.8 (2.6, 16.5) 14.0 (8.5, 22.1) 19.5 (6.0, 47.9) 9.8 (8.5, 11.3) 12.7 (4.4, 31.4) 9.1 (7.9, 10.6) 10.3 (3.6, 26.3) Nationally Registered ACT Urban Rural Any non-artemisinin therapy Urban Rural Sulfadoxine-Pyrimethamine Urban Rural Oral Quinine Urban Rural Quinine IV/IM Urban Rural Other non-artemisinin therapy Urban Rural www.ACTwatch.info Page 61 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location Proportion of outlets* stocking: Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=160 Rural N=297 Urban N=27 Rural N=16 Urban N=190 Rural N=327 Urban N=262 Rural N=80 Urban N=439 Rural N=48 Urban N=440 Rural N=95 Urban N=72 Rural N=180 Urban N=1,213 Rural N=403 Urban N=1,403 Rural N=730 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 0.2 (0.1, 0.6) 0.0 - 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 0.1 (0.0, 0.2) 0.0 - 0.1 (0.0, 0.2) 0.0 - 54.7 (47.2, 61.9) 55.1 (46.5, 63.3) 59.9 (49.7, 69.3) 64.0 (35.5, 85.1) 52.4 (45.7, 59.0) 49.6 (38.9, 60.4) 48.7 (44.4, 53.1) 27.8 (18.2, 39.9) 25.5 (20.9, 30.7) 22.8 (14.0, 35.0) 9.7 (7.1, 13.1) 7.7 (3.6, 15.9) 2.8 (1.0, 7.8) 0.0 - 22.5 (19.5, 25.8) 7.7 (4.8, 12.0) 24.8 (21.7, 28.1) 16.2 (12.6, 20.7) 7.6 (5.3, 10.7) 2.2 (0.7, 6.7) 44.3 (32.8, 56.3) 64.0 (35.5, 85.1) 20.2 (14.8, 26.9) 16.8 (6.9, 35.6) 42.9 (39.3, 46.5) 23.7 (17.0, 32.0) 24.9 (20.3, 30.2) 22.8 (14.0, 35.0) 9.5 (7.1, 12.7) 7.7 (3.6, 15.9) 2.8 (1.0, 7.8) 0.0 - 20.6 (18.0, 23.4) 6.9 (4.4, 10.6) 20.5 (18.0, 23.3) 8.9 (5.9, 13.3) 52.0 (44.5, 59.5) 54.7 (46.0, 63.0) 28.3 (17.8, 41.8) 0.0 - 39.5 (32.1, 47.5) 33.9 (24.7, 44.5) 10.5 (8.2, 13.3) 4.1 (0.7, 20.8) 4.5 (2.7, 7.7) 2.8 (0.5, 13.0) 1.7 (0.8, 3.6) 0.0 - 0.0 0.0 - 4.5 (3.2, 6.1) 0.8 (0.2, 4.4) 7.1 (5.6, 9.0) 7.6 (5.6, 10.2) 0.0 0.0 - 0.0 0.0 - 0.0 0.0 - 2.6 (1.6, 4.3) 0.0 - 5.7 (3.4, 9.3) 2.4 (0.4, 14.0) 1.2 (0.7, 2.2) 0.0 - 0.0 0.0 - 2.1 (1.3, 3.3) 0.0 (0.0, 0.3) 1.9 (1.2, 3.0) 0.0 (0.0, 0.2) Oral artemisinin monotherapy Urban Rural Non-oral artemisinin monotherapy Urban Rural Injectable artemether Urban Rural Injectable artesunate Urban Rural Injectable artemotil Urban Rural www.ACTwatch.info Page 62 Table B2: Availability of antimalarials, among all outlets stocking at least one antimalarial, by outlet type, across urban/rural location Proportion of outlets* stocking: Public Health Facility Private Not ForProfit Facility ALL Public / NotFor-Profit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=160 Rural N=297 Urban N=27 Rural N=16 Urban N=190 Rural N=327 Urban N=262 Rural N=80 Urban N=439 Rural N=48 Urban N=440 Rural N=95 Urban N=72 Rural N=180 Urban N=1,213 Rural N=403 Urban N=1,403 Rural N=730 76.3 (69.7, 81.8) 82.7 (76.0, 87.8) 69.9 (58.1, 79.5) 86.8 (62.7, 96.2) 68.2 (61.5, 74.2) 72.2 (60.0, 81.9) 62.1 (57.7, 66.4) 51.1 (38.5, 63.6) 27.1 (22.4, 32.3) 38.9 (24.4, 55.7) 14.1 (10.5, 18.6) 27.9 (19.4, 38.2) 2.8 (1.0, 7.8) 0.5 (0.1, 3.2) 28.7 (25.4, 32.2) 17.7 (12.1, 25.2) 31.7 (28.1, 35.6) 28.8 (22.5, 36.1) Any treatment for severe malaria Urban Rural * Antimalarial-stocking outlets have at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. The denominator includes urban and rural outlets that met screening criteria and completed full interviews. 67 outlets in the denominator had partial interviews. Urban: 48 outlets. Rural: 19 outlets. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 63 Table B3: Antimalarial market composition, across urban/rural location Outlet type, among outlets with at least 1 antimalarial in stock on the day of the survey:* Urban, N= 1,029 Rural, N=472 Public Health Facility Community Health Worker Private NotFor-Profit Facility ALL Public / NotFor-Profit Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private % % % % % % % % % 5.6 0.5 2.6 8.7 25.4 16.0 41.0 8.9 91.3 (4.5, 6.8) (0.3, 1.2) (1.9, 3.4) (7.1, 10.5) (23.6, 27.3) (11.3, 22.2) (35.4, 46.8) (6.3, 12.6) (89.5, 92.9) 16.8 2.6 4.5 23.9 14.0 4.1 18.3 39.6 76.1 (12.6, 22.0) (1.0, 6.3) (2.3, 8.9) (17.9, 31.2) (10.6, 18.2) (2.1, 7.9) (12.8, 25.7) (28.3, 52.2) (68.8, 82.1) * Excluding booster sample outlets. Outlets with at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 64 Table B4a: Price of tablet formulation antimalarials, by outlet type, across urban/rural location Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) Urban $2.25 [1.50-4.51] (530) $3.38 [1.69-5.63] (1,961) $2.25 [1.35-4.51] (1,230) $2.82 [1.13-5.63] (48) $2.70 [1.35-4.73] (3,769) Rural $1.69 [1.13-3.38] (125) $1.80 [1.13-3.94] (154) $1.35 [1.13-2.93] (202) $1.35 [1.13-1.69] (36) $1.58 [1.13-2.82] (517) Urban $1.69 [1.13-3.38] (383) $1.69 [1.13-2.82] (1,017) $1.69 [1.13-2.25] (816) $1.35 [1.13-2.25] (38) $1.69 [1.13-2.70] (2,254) Rural $1.69 [1.13-2.25] (93) $1.35 [1.13-1.69] (99) $1.13 [1.13-1.58] (145) $1.35 [1.13-1.69] (35) $1.35 [1.13-1.69] (372) Urban $5.63 [5.07-5.86] (10) $5.63 [5.07-6.08] (74) $5.07 [4.51-6.76] (16) $9.91 [8.56-11.26] (2) $5.63 [5.07-7.88] (102) Rural $6.20 [5.07-6.20] (2) $4.73 [4.51-4.73] (2) $6.76 [3.94-7.88] (3) - $6.20 [4.73-6.76] (7) Urban $1.69 [1.13-2.25] (342) $1.35 [1.13-1.80] (802) $1.58 [1.13-2.03] (682) $1.13 [1.13-1.50] (34) $1.69 [1.13-2.25] (1,860) Rural $1.69 [1.13-2.25] (91) $1.13 [1.13-1.69] (87) $1.13 [1.13-1.35] (136) $1.35 [1.13-1.69] (35) $1.13 [1.13-1.69] (349) Urban $1.69 [1.13-2.25] (282) $1.35 [1.13-2.03] (708) $1.58 [1.13-2.25] (609) $1.13 [1.13-1.69] (29) $1.69 [1.13-2.25] (1,628) Rural $1.50 [1.13-2.03] (78) $1.13 [1.13-1.69] (76) $1.13 [1.13-1.35] (116) $1.35 [1.13-1.69] (32) $1.13 [1.13-1.69] (302) Median price of a tablet AETD*: Any ACT Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) Quality Assured ACT (QA ACT) QA ACT with ‘green leaf’ logo www.ACTwatch.info Page 65 Private For-Profit Facility Median price of a tablet AETD*: Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $1.69 $1.35 $1.50 $1.13 $1.35 QA ACT without the ‘green leaf’ logo Urban [1.13-2.25] (59) [1.13-1.80] (94) [1.13-1.69] (72) [1.13-1.35] (5) [1.13-1.80] (230) Rural $1.69 [1.13-2.25] (12) $1.13 [1.13-1.35] (11) $1.13 [0.90-1.35] (20) $1.69 [1.69-1.69] (3) $1.13 [1.01-1.69] (46) Urban $1.69 [1.13-2.25] (323) $1.35 [1.13-1.80] (725) $1.50 [1.13-1.80] (651) $1.13 [1.13-1.50] (34) $1.58 [1.13-2.25] (1,733) Rural $1.69 [1.13-2.25] (87) $1.13 [1.13-1.69] (84) $1.13 [1.13-1.35] (130) $1.35 [1.13-1.69] (35) $1.13 [1.13-1.69] (336) Urban $4.51 [3.38-5.68] (188) $5.07 [3.38-9.12] (1,159) $4.73 [3.83-7.88] (548) $6.76 [3.38-11.26] (14) $4.73 [3.38-7.88] (1,909) Rural $3.94 [3.15-5.07] (34) $3.94 [3.38-5.07] (67) $3.94 [3.15-5.41] (66) $3.94 $3.94 [3.15-5.07] (168) Urban $0.79 [0.56-1.35] (71) $0.79 [0.56-1.69] (428) $0.56 [0.56-1.13] (392) $0.34 [0.34-0.51] (47) $0.56 [0.56-1.13] (938) Rural $0.56 [0.34-0.56] (26) $0.56 [0.45-0.84] (52) $0.56 [0.45-0.68] (89) $0.34 [0.34-0.45] (148) $0.39 [0.34-0.56] (315) Urban $4.73 [2.37-7.10] (10) $3.78 [3.31-4.73] (46) $3.78 [2.37-4.73] (22) $1.14 $3.78 [2.37-4.73] (79) QA AL Non-quality-assured ACT (non-QA ACT) (1) Sulfadoxine-Pyrimethamine Quinine (1) $7.10 $3.78 $4.73 $4.73 [2.37-7.10] (3) [2.84-4.73] (5) [4.73-4.73] (8) [3.31-4.73] (16) * AETD - adult equivalent treatment dose - is or the number of milligrams required to treat a 60kg adult (see Annex 11). Information provided by the respondent about price for a specific amount of antimalarial drug (e.g. price per tablet or price per specific package size) was converted to the price per AETD. Figures in this table are derived using audited products with price information. The numbers of antimalarials captured in audit sheets with missing price information are as follows: 73 any ACT tablets, 47 artemether lumefantrine tablets, 2 artesunate sulfadoxine pyrimethamine tablets, 46 QA ACT tablets, 39 QA ACT with AMFm logo tablets, 6 QA ACT without AMFm logo tablets, 41 QA artemether lumefantrine tablets, 27 non-QA ACT tablets, 7 sulfadoxine pyrimethamine tablets, 1 quinine tablet. Rural Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 66 Table B4b: Price of pre-packaged antimalarials, by outlet type, across urban/rural location Private For-Profit Facility Median price of one prepackaged therapy: Registered Pharmacy Unregistered Pharmacy ALL Private General Retailer Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $1.69 $1.13 $1.13 $1.13 $1.13 Adult QA AL Urban Rural [1.13-1.69] (185) $1.13 [1.13-1.69] [1.13-1.69] (404) $1.13 (55) [1.13-1.35] [1.13-1.69] (382) $1.13 (48) [1.13-1.13] [1.13-1.13] (19) [1.13-1.69] (990) $1.13 (78) [1.13-1.69] $1.13 (23) [1.13-1.35] (204) Pediatric QA AL* Urban Rural $0.68 [0.56-1.13] $0.56 (49) $0.56 [0.56-1.13] [0.45-0.90] $0.56 (147) $0.56 (16) [0.34-0.56] [0.56-0.90] $0.56 (116) $0.56 (14) [0.56-0.68] (15) [0.56-1.13] $0.56 (6) [0.56-1.13] (318) - $0.56 - [0.56-0.90] (45) *QA AL is the pre-packaged regimen appropriate for a child under age five. Figures in this table are derived using audited products with price information. The numbers of antimalarials captured in audit sheets with missing price information are as follows: 27 adult QA AL, 5 pediatric QA AL Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 67 Table B5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type, across urban/rural location Public Health Facility % (95% CI) ALL Public / Not- ForProfit** % (95% CI) Private For-Profit Facility % (95% CI) Urban N=171 Rural N=300 Urban N=212 Rural N=361 Urban 96.2 (93.9, 97.6) Rural Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=285 Rural N=90 Urban N=443 Rural N=47 Urban N=457 Rural N=99 Urban N=124 Rural N=281 Urban N=1,309 Rural N=517 Urban N=1,521 Rural N=878 91.1 (83.1, 95.5) 79.1 (70.6, 85.7) 80.2 (76.6, 83.4) 21.5 (18.3, 25.1) 18.2 (15.1, 21.9) 0.0 - 33.0 (29.6, 36.6) 92.4 (85.4, 96.2) 91.0 (77.7, 96.7) 69.5 (40.0, 88.6) 55.1 (44.0, 65.8) 13.4 (6.4, 25.9) 7.5 (3.9, 13.9) 0.0 - 10.7 (7.1, 15.8) Urban N=170 Rural N=300 Urban N=211 Rural N=360 Urban N=285 Rural N=90 Urban N=443 Rural N=47 Urban N=456 Rural N=99 Urban N=122 Rural N=281 Urban N=1,306 Rural N=517 Urban N=1,517 Rural N=877 Urban 70.6 (65.6, 75.2) 62.7 (54.2, 70.5) 66.2 (61.5, 70.6) 8.0 (6.2, 10.4) 6.4 (4.7, 8.6) 0.0 - 22.5 (20.0, 25.2) 25.8 (23.4, 28.3) Rural 54.1 (48.4, 59.8) 38.2 (21.5, 58.3) 44.8 (34.5, 55.6) 10.8 (4.9, 22.0) 2.7 (0.9, 7.8) 0.0 - 8.1 (5.1, 12.4) 14.6 (10.6, 19.9) Urban N=170 Rural N=300 Urban N=210 Rural N=361 Urban N=285 Rural N=90 Urban N=443 Rural N=47 Urban N=456 Rural N=99 Urban N=123 Rural N=280 Urban N=1,307 Rural N=516 Urban N=1,517 Rural N=877 Urban 61.8 (54.0, 69.0) 44.8 (38.7, 51.1) 30.8 (27.4, 34.4) 15.8 (12.3, 20.0) 14.2 (12.0, 16.6) 0.0 - 16.7 (14.7, 18.9) 18.9 (17.3, 20.7) Rural 72.7 (65.0, 79.3) 55.7 (35.4, 74.3) 24.3 (15.0, 36.9) 4.4 (1.1, 16.7) 4.8 (2.0, 10.6) 0.0 - 5.0 (2.9, 8.5) 16.1 (11.9, 21.3) Urban N=170 Rural N=299 Urban N=210 Rural N=360 Urban N=284 Rural N=90 Urban N=443 Rural N=47 Urban N=456 Rural N=99 Urban N=123 Rural N=280 Urban N=1,305 Rural N=516 Urban N=1,515 Rural N=876 Urban 0.2 (0.1, 0.5) 0.1 (0.0, 0.3) 0.6 (0.3, 1.5) 1.4 (0.6, 3.4) 0.0 - 0.0 - 0.3 (0.2, 0.6) 0.3 (0.2, 0.6) Rural 0.0 - 0.4 (0.1, 2.3) 0.0 - 0.0 - 0.0 - 0.0 - 0.0 - 0.1 (0.0, 0.5) Proportion of outlets*** stocking Any malaria blood testing Microscopic blood tests Rapid diagnostic tests (RDTs) Checkmark RDTs * Blood testing availability is reported among outlets that either had antimalarials in stock on the day of the survey or reportedly stocked antimalarials in the previous 3 months. *** Results in this table are derived using responses captured among outlets with blood testing information. 6 antimalarial-stocking outlets had missing information about both availability of microscopy and availability of RDTs. 18 antimalarial-stocking outlets had partial information about blood testing availability and are included in the denominator of the indicator “any blood testing available.” Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 68 Table B7: Price of malaria blood testing, by outlet type, across urban/rural location Private For-Profit Facility Total median price to consumers:* Registered Pharmacy Unregistered Pharmacy ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $1.13 $1.13 $1.13 $1.13 [1.13-1.69] (222) [1.13-1.69] (50) [1.13-1.13] (27) [1.13-1.69] (299) $0.56 $0.56 $0.45 $0.56 [0.56-1.13] (41) [0.45-0.56] (5) [0.45-1.13] (3) [0.56-1.13] (49) $1.13 $1.13 $1.13 $1.13 Microscopic blood tests Adult Urban Rural Child under age five Urban [0.56-1.69] Rural (222) $0.56 [0.56-0.56] [1.13-1.13] (50) $0.56 (41) [0.45-0.56] [1.13-1.13] (27) $0.45 (5) [0.45-1.13] [0.56-1.69] (299) $0.56 (3) [0.56-0.90] (49) Rapid diagnostic tests (RDTs) Adult Urban $1.13 [1.13-1.69] Rural $1.13 (109) $1.13 [0.56-1.13] [1.13-1.13] $1.13 (53) $0.96 (25) [0.79-1.13] [1.13-1.69] $1.13 (54) $0.56 (2) [0.56-1.13] [1.13-1.69] (216) $1.13 (5) [0.56-1.13] (32) Child under five Urban $1.13 [1.13-1.69] Rural $1.13 (108) $1.13 [0.56-1.13] (25) [1.13-1.13] $1.13 (51) $0.73 [0.56-0.90] (2) $1.13 (54) [1.13-1.69] (213) $0.56 [0.56-1.13] (5) $1.13 [0.56-1.13] (32) [1.13-1.13] www.ACTwatch.info Page 69 Table B7: Price of malaria blood testing, by outlet type, across urban/rural location Private For-Profit Facility Median [IQR] Median price excluding fees:** Registered Pharmacy Unregistered Pharmacy ALL Private Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $0.17 $1.13 $0.79 $0.68 (1) [0.56-1.69] (12) [0.56-1.13] (20) [0.56-1.13] (33) - $0.90 $0.45 $0.45 - (1) (1) [0.45-0.45] (2) $0.17 $0.68 Rapid diagnostic tests (RDTs) Adult Urban Rural Child under five Urban (1) Rural [0.56-1.69] $0.79 (11) [0.56-1.13] $0.68 (20) [0.56-1.13] (32) - $0.90 $0.45 $0.45 - (1) (1) [0.45-0.45] (2) * Total price to the consumer including consultation and/or service fees. ** Price to the consumer for an RDT excluding consultation and/or service fees. Microscopic blood testing price information was not available for all outlets. There were 6 outlets with missing or “don’t know” responses. RDT price information was not available (missing or “don’t know” response) for: 31 adult RDTs and 34 child RDTs in median price to consumers and 244 adult RDTs and 245 child RDTs in median price excluding fees. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 70 Table B8a: Antimalarial market share, urban Public Health Facility TOTAL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private ANTI-MALARIAL TOTAL*** % % % % % % % % 5.7 7.3 9.6 32.7 20.4 1.1 63.8 71.2 Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHAPPQ 5.6 6.9 8.3 25.0 17.1 0.9 51.3 58.2 0.0 0.0 0.1 0.3 0.1 0.0 0.5 0.5 0.1 0.4 0.8 5.8 2.4 0.2 9.2 9.5 Quality Assured ACT (QA ACT) AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed:* 1. Any ACT 5.6 6.8 6.7 20.6 15.3 0.5 43.0 49.8 QA ACT with the ‘green leaf’ logo 3.4 4.1 5.1 16.8 13.7 0.4 36.1 40.2 QA ACT without the ‘green leaf’ logo 2.3 2.7 1.5 3.8 1.6 0.0 6.9 9.6 Non-quality-assured ACT 0.1 0.5 3.0 12.1 5.1 0.6 20.8 21.3 Nationally Registered ACT 5.6 7.2 8.7 25.7 17.7 0.8 52.9 60.2 2. Any non-artemisinin therapy 0.9 1.0 1.7 14.8 8.8 1.0 26.3 27.2 Sulfadoxine-Pyrimethamine 0.7 0.7 1.5 13.8 8.3 1.0 24.5 25.2 Oral Quinine 0.0 0.1 0.0 0.3 0.1 0.0 0.4 0.5 Quinine IV/IM 0.1 0.2 0.1 0.3 0.1 0.0 0.4 0.6 3. Oral artemisinin monotherapy 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.1 0.2 0.4 0.7 0.2 0.0 1.4 1.6 Injectable artesunate 0.1 0.1 0.1 0.0 0.1 0.0 0.2 0.3 Injectable artemether 0.0 0.1 0.3 0.7 0.2 0.0 1.1 1.3 Injectable artemotil 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.5 1.0 0.3 0.0 1.8 2.1 6.7 8.5 11.7 48.2 29.5 2.1 91.5 100.0 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** * A total of 30,012.7 AETDs were reportedly sold or distributed in the previous seven days. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. *** Row sum – market share for the specified antimalarial medicine. **** Column sum – market share for the specified outlet type. Categories 1 through 4 sum to 100% in the far-right column – antimalarial total column. A total of 5,313 antimalarials were audited. Of these, 230 audited antimalarials were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 71 Table B8b: Antimalarial market share, rural AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed:* 1. Any ACT Public Health Facility TOTAL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private ANTIMALARIAL TOTAL*** % % % % % % % % 15.0 21.3 9.3 4.4 22.5 7.4 43.6 64.9 Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHAPPQ 15.0 21.1 8.5 3.9 20.7 7.3 40.4 61.5 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.7 0.5 1.5 0.1 2.7 2.9 Quality Assured ACT (QA ACT) 15.0 20.5 8.0 3.6 20.4 7.3 39.2 59.7 QA ACT with the ‘green leaf’ logo 5.9 7.8 7.2 2.7 15.5 5.6 30.9 38.8 QA ACT without the ‘green leaf’ logo 9.1 12.6 0.8 0.9 4.9 1.7 8.3 20.9 Non-quality-assured ACT 0.0 0.9 1.4 0.7 2.2 0.1 4.3 5.2 Nationally Registered ACT 13.9 19.6 8.8 4.1 19.9 7.1 39.9 59.5 2. Any non-artemisinin therapy 5.8 7.0 2.1 3.4 12.4 9.6 27.6 34.6 Sulfadoxine-Pyrimethamine 4.8 4.9 1.9 3.4 11.9 9.3 26.5 31.3 Oral Quinine 0.8 1.8 0.0 0.0 0.1 0.0 0.2 1.9 Quinine IV/IM 0.3 0.3 0.2 0.0 0.2 0.0 0.5 0.8 3. Oral artemisinin monotherapy 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.2 0.2 0.1 0.0 0.1 0.0 0.3 0.5 Injectable artesunate 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 Injectable artemether 0.0 0.1 0.1 0.0 0.1 0.0 0.3 0.3 Injectable artemotil 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.6 0.3 0.0 0.4 0.0 0.7 1.3 21.0 28.6 11.6 7.8 35.1 17.0 71.4 100.0 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** * A total of 5,632.6 AETDs were reportedly sold or distributed in the previous seven days. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. *** Row sum – market share for the specified antimalarial medicine. **** Column sum – market share for the specified outlet type. Categories 1 through 4 sum to 100% in the far-right column – antimalarial total column. A total of 1,338 antimalarials were audited. Of these, 95 audited antimalarials were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 72 Table B9a: Antimalarial market share across outlets, urban AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed:* 1. Any ACT Public Health Facility TOTAL Public / Not ForProfit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private % % % % % % % 85.3 86.4 81.9 67.9 69.2 53.0 69.8 Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHAPPQ 84.3 81.6 70.8 51.8 58.0 42.0 56.0 0.0 0.0 0.6 0.6 0.4 0.7 0.5 0.8 4.5 7.1 12.0 8.1 8.3 10.0 Quality Assured ACT (QA ACT) 84.2 80.4 56.7 42.7 51.9 22.6 47.0 QA ACT with the ‘green leaf’ logo 50.2 48.4 43.9 34.8 46.6 20.3 39.5 QA ACT without the ‘green leaf’ logo 33.9 32.0 12.8 7.9 5.3 2.2 7.5 Non-quality-assured ACT 1.1 6.0 25.3 25.2 17.3 30.4 22.8 Nationally Registered ACT 84.4 85.0 73.8 53.4 60.1 38.7 57.9 2. Any non-artemisinin therapy 13.4 11.2 14.6 30.6 29.9 47.0 28.7 Sulfadoxine-Pyrimethamine 10.0 8.2 12.7 28.6 28.1 46.4 26.8 Oral Quinine 0.7 0.7 0.4 0.6 0.4 0.0 0.5 Quinine IV/IM 2.2 1.9 0.8 0.5 0.2 0.0 0.4 3. Oral artemisinin monotherapy 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 1.3 2.4 3.3 1.5 0.8 0.0 1.5 Injectable artesunate 1.3 1.0 0.7 0.0 0.3 0.0 0.2 Injectable artemether 0.1 1.4 2.4 1.5 0.5 0.0 1.2 Injectable artemotil 0.0 0.0 0.3 0.0 0.0 0.0 0.0 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** 3.5 4.3 4.1 2.0 1.1 0.0 1.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 * AETDs reportedly sold or distributed in the previous seven days: 1,966.9 public health facility; 468.5 private-not-for-profit HF; 3,334.2 private for-profit HF; 15,226.0 Registered Pharmacy; 8665.3 Unregistered Pharmacy; 337.7 general retailer. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. Categories 1 through 4 sum to 100% within each column. A total of 5,313 antimalarials were audited. Of these, 230 audited antimalarials were not included in market share calculations due to incomplete or inconsistent information, including the following number of antimalarials by outlet type: 19 public health facilities; 1 private not-for profit facilities; 63 private for-profit facilities; 49 registered pharmacies; 91 unregistered pharmacies; 7 general retailers. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 73 Table B9b: Antimalarial market share across outlets, rural AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed:* 1. Any ACT Public Health Facility TOTAL Public / Not ForProfit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private % % % % % % % 71.7 74.6 80.5 56.0 64.3 43.4 61.0 Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHAPPQ 71.7 73.8 73.4 49.9 59.0 43.0 56.5 0.0 0.0 0.8 0.0 0.2 0.0 0.2 0.0 0.8 5.9 5.8 4.3 0.4 3.8 Quality Assured ACT (QA ACT) 71.7 71.6 68.8 46.4 58.1 43.0 55.0 QA ACT with the ‘green leaf’ logo QA ACT without the ‘green leaf’ logo Non-quality-assured ACT 28.3 27.4 62.2 34.6 44.1 32.7 43.3 43.4 44.1 6.6 11.8 14.0 10.3 11.7 0.0 3.0 11.7 9.5 6.2 0.4 6.1 Nationally Registered ACT 66.3 68.5 76.2 52.3 56.9 41.7 55.9 2. Any non-artemisinin therapy 27.6 24.5 18.5 43.9 35.4 56.6 38.6 Sulfadoxine-Pyrimethamine 22.7 17.0 16.3 43.3 34.0 54.7 37.1 Oral Quinine 3.6 6.2 0.3 0.2 0.4 0.0 0.2 Quinine IV/IM 1.2 1.2 1.6 0.3 0.7 0.0 0.6 3. Oral artemisinin monotherapy 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.8 0.8 1.0 0.1 0.3 0.0 0.4 Injectable artesunate 0.7 0.5 0.0 0.0 0.0 0.0 0.0 Injectable artemether 0.1 0.3 1.0 0.1 0.3 0.0 0.4 Injectable artemotil 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5. Any treatment for severe malaria OUTLET TYPE TOTAL**** 2.0 2.0 2.7 0.5 1.0 0.0 1.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 * 5632.6 AETDs reportedly sold or distributed in the previous seven days: 916.9 public health facility; 72.5 CHW; 370.5 private-not-for-profit HF; 743.2 private for-profit HF; 562.5 Registered Pharmacy; 2,111.8 Unregistered Pharmacy; 855.2 general retailer. See Annex 11 for a description of AETD calculation and Annex 12 for AETD numbers by outlet type and drug category. Categories 1 through 4 sum to 100% within each column. A total of 1,338 antimalarials were audited. Of these, 95 audited antimalarials were not included in market share calculations due to due to incomplete or inconsistent information, including the following number of antimalarials by outlet type: 8 public health facility; 1 community health worker;17 private for-profit; 12 registered pharmacy; 32 unregistered pharmacy; 25 general retailer. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 74 Table B12: Provider case management knowledge and practices, by outlet type, across urban/rural location Proportion of providers who: Would refer a 2 year old child with symptoms of severe malaria to a health facility Public Health Facility % (95% CI) ALL Public / Not ForProfit** % (95% CI) Private For-Profit Facility % (95% CI) - Urban N=16 Rural N=43 - Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=443 Rural N=47 Urban N=451 Rural N=99 Urban N=124 Rural N=279 Urban N=1,018 Rural N=425 Urban N=1,034 Rural N=468 90.6 (87.5, 93.0) 90.6 (79.9, 95.9) 86.0 (83.1, 88.5) 80.2 (68.8, 88.1) 87.7 (84.6, 90.2) 88.8 (81.4, 93.4) 87.1 (84.9, 89.1) 86.8 (80.8, 91.1) 87.5 (85.3, 89.5) 87.0 (81.7, 91.0) Yes, would refer to health facility Urban NA Rural NA Would recommend that a client with a negative malaria blood test take an antimalarial 100.0 89.1 (77.7, 95.0) NA NA Urban N=166 Rural N=291 Urban N=208 Rural N=353 Urban N=278 Rural N=82 Urban N=395 Rural N=34 Urban N=378 Rural N=79 Urban N=55 Rural N=88 Urban N=1,106 Rural N=283 Urban N=1,314 Rural N=636 26.5 (22.2, 31.3) 17.5 (12.8, 23.5) 32.7 (27.0, 39.0) 15.2 (8.5, 25.6) 31.2 (27.7, 34.9) 28.8 (19.9, 39.7) 30.4 (27.2, 33.8) 24.1 (13.2, 39.8) 31.2 (27.6, 35.1) 24.9 (15.2, 37.8) 12.5 (8.9, 17.3) 10.2 (5.6, 17.9) 29.3 (27.2, 31.6) 20.5 (15.9, 26.0) 29.7 (27.5, 32.0) 18.6 (13.9, 24.5) 6.1 (3.9, 9.4) 3.7 (1.8, 7.6) 4.5 (2.9, 6.9) 2.6 (1.5, 4.6) 6.6 (4.2, 10.0) 4.4 (1.6, 11.7) 2.8 (2.0, 4.0) 0.0 - 1.5 (0.9, 2.4) 5.0 (1.6, 14.5) 1.8 (0.7, 4.7) 11.3 (4.1, 27.7) 3.4 (2.6, 4.5) 7.1 (3.7, 13.1) 3.5 (2.7, 4.6) 5.5 (3.2, 9.4) Urban N=46 Rural N=57 Urban N=63 Rural N=67 Urban N=103 Rural N=27 Urban N=119 Rural N=7 Urban N=125 Rural N=21 Urban N=8 Rural N=16 Urban N=355 Rural N=71 Urban N=418 Rural N=138 98.3 (94.8, 99.4) 98.9 (93.5, 99.8) 93.8 (87.9, 97.0) 96.2 (83.0, 99.2) 86.8 (82.2, 90.3) 95.9 (82.0, 99.2) 90.9 (86.8, 93.8) 83.9 (48.9, 96.6) 84.0 (80.5, 87.0) 96.2 (83.7, 99.2) 100.0 56.3 (32.1, 77.7) 86.6 (83.3, 89.3) 84.2 (74.3, 90.7) 87.4 (84.0, 90.2) 87.3 (79.7, 92.4) Yes – sometimes Urban Rural Yes – always Urban Rural Circumstances cited for recommending antimalarial treatment to a client who tested negative for malaria:* Patient has signs and symptoms of malaria. Urban Rural www.ACTwatch.info Page 75 Table B12: Provider case management knowledge and practices, by outlet type, across urban/rural location Proportion of providers who: Public Health Facility % (95% CI) ALL Public / Not ForProfit** % (95% CI) Private For-Profit Facility % (95% CI) 26.5 17.0 (16.1, 40.3) (10.2, 26.8) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 7.8 11.7 16.8 - 12.0 12.5 (5.5, 11.0) (8.0, 16.9) (12.9, 21.5) - (9.3, 15.2) (9.9, 15.7) Provider doesn't trust the test results. Urban Rural 11.7 15.5 6.6 8.4 11.5 36.4 17.0 16.6 (5.6, 22.7) (5.6, 36.4) (1.8, 21.2) (1.4, 37.9) (2.3, 42.1) (9.8, 75.1) (7.5, 34.0) (8.6, 29.8) 4.5 1.9 4.4 10.2 8.5 6.1 7.0 6.4 (1.6, 11.9) (0.6, 5.6) (2.4, 7.9) (7.3, 14.0) (6.2, 11.6) (1.9, 17.9) (5.2, 9.4) (4.8, 8.5) 12.6 6.3 2.4 8.4 - - 1.0 2.4 (6.7, 22.6) (2.8, 13.5) (0.4, 13.1) (1.4, 37.9) - - (0.2, 4.5) (1.0, 5.5) 90.6 84.5 87.2 83.2 76.2 82.8 81.7 82.0 (82.9, 95.1) (74.2, 91.1) (79.6, 92.3) (72.8, 90.1) (61.6, 86.5) (63.7, 93.0) (72.4, 88.3) (73.0, 88.5) 70.6 61.8 89.0 100.0 85.9 92.5 89.2 82.0 (42.9, 88.5) (33.5, 83.9) (71.3, 96.3) - (60.1, 96.1) (67.2, 98.7) (77.0, 95.3) (63.5, 92.3) When the patient asks for antimalarial treatment. Urban Rural Other (all other reasons) Urban Rural Provider questions were administered to one staff member working in each outlet eligible for a full interview (current/recent antimalarial-stocking outlets or outlets providing malaria blood testing). * No providers were missing information on circumstances for recommending antimalarials to clients who tested negative for malaria. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 76 Table B13: Provider antimalarial treatment knowledge and practices, by outlet type, across urban/rural location Proportion of providers who: Public Health Facility % (95% CI) ALL Public / Not ForProfit* % (95% CI) Private For-Profit Facility % (95% CI) Urban N=171 Rural N=300 Urban N=212 Rural N=361 99.5 (98.8, 99.8) 98.2 (96.0, 99.2) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) Urban N=285 Rural N=90 Urban N=444 Rural N=48 Urban N=458 Rural N=99 Urban N=125 Rural N=283 Urban N=1,312 Rural N=520 Urban N=1,524 Rural N=881 95.7 (93.0, 97.4) 96.3 (92.7, 98.2) 93.3 (91.9, 94.5) 91.1 (82.9, 95.6) 96.1 (93.6, 97.7) 96.5 (89.3, 98.9) 91.1 (89.1, 92.8) 90.4 (82.2, 95.1) 33.3 (25.0, 42.6) 27.3 (18.9, 37.5) 82.4 (77.5, 86.5) 51.2 (40.6, 61.8) 83.5 (79.0, 87.2) 61.1 (49.7, 71.4) 97.1 (94.8, 98.5) 95.1 (89.7, 97.7) 83.5 (75.4, 89.3) 91.3 (84.6, 95.2) 87.2 (84.9, 89.2) 89.7 (82.8, 94.1) 89.6 (87.5, 91.5) 93.2 (84.7, 97.2) 86.3 (83.8, 88.5) 85.7 (76.9, 91.6) 18.6 (11.2, 29.5) 16.5 (11.5, 23.3) 75.4 (69.3, 80.7) 43.4 (33.8, 53.5) 76.1 (70.1, 81.2) 53.8 (43.5, 63.9) 87.7 (82.4, 91.5) 87.9 (82.9, 91.6) 78.4 (72.0, 83.6) 79.5 (68.7, 87.2) 71.6 (68.6, 74.4) 77.5 (64.4, 86.8) 81.3 (78.8, 83.6) 77.5 (62.7, 87.6) 73.3 (70.3, 76.1) 76.2 (63.3, 85.6) 9.5 (5.8, 15.2) 10.4 (6.4, 16.6) 62.8 (57.6, 67.7) 35.4 (26.6, 45.4) 64.1 (59.0, 68.8) 45.0 (35.9, 54.5) 96.7 (94.1, 98.1) 96.7 (92.9, 98.5) 92.9 (87.2, 96.1) 94.6 (89.7, 97.2) 91.3 (89.1, 93.1) 82.5 (73.8, 88.8) 95.6 (93.9, 96.8) 86.8 (77.5, 92.6) 89.1 (87.5, 90.5) 81.6 (73.8, 87.5) 37.7 (26.1, 51.0) 24.7 (13.3, 41.4) 81.7 (75.9, 86.3) 46.4 (33.9, 59.3) 82.6 (77.0, 87.1) 56.9 (44.1, 68.9) 90.5 (86.0, 93.7) 97.7 (95.0, 99.0) 92.1 (89.2, 94.2) 91.3 (86.5, 94.5) 89.0 (86.8, 90.9) 81.8 (71.9, 88.8) 96.5 (95.0, 97.6) 93.7 (79.2, 98.3) 87.5 (85.3, 89.4) 77.6 (68.5, 84.7) 29.1 (18.9, 42.0) 18.2 (9.3, 32.7) 79.0 (72.8, 84.1) 41.5 (30.0, 54.1) 80.1 (74.4, 84.7) 52.4 (40.5, 64.0) Correctly state the national first-line treatment for uncomplicated malaria Urban Rural Correctly state the first-line dosing regimen for an adult Urban Rural Correctly state the first-line dosing regimen for a child Urban Rural Report an ACT as the most effective antimalarial medicine for an adult Urban Rural Report an ACT as the most effective antimalarial medicine for a child Urban Rural www.ACTwatch.info Page 77 Table B13: Provider antimalarial treatment knowledge and practices, by outlet type, across urban/rural location Public Health Facility % (95% CI) ALL Public / Not ForProfit* % (95% CI) Private For-Profit Facility % (95% CI) 99.4 (98.7, 99.7) 97.8 (93.6, 99.3) 91.3 (87.2, 94.2) 98.4 (95.5, 99.4) 97.5 (94.7, 98.8) 98.4 (93.5, 99.6) 94.0 (91.7, 95.7) 96.8 (91.0, 98.9) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 93.6 (91.7, 95.1) 91.5 (85.0, 95.3) 94.4 (92.3, 96.0) 90.7 (78.3, 96.4) 86.0 (84.0, 87.8) 84.7 (73.3, 91.8) 36.1 (25.7, 48.0) 21.3 (10.2, 39.2) 80.6 (75.5, 84.8) 46.4 (32.8, 60.6) 81.5 (76.6, 85.5) 57.7 (43.2, 71.1) 88.7 (86.7, 90.5) 84.4 (75.9, 90.3) 95.3 (93.0, 96.9) 90.9 (77.9, 96.6) 84.0 (81.1, 86.5) 77.7 (65.5, 86.5) 28.0 (17.9, 40.9) 16.8 (8.5, 30.5) 77.0 (71.6, 81.7) 41.1 (29.4, 53.9) 78.4 (73.5, 82.7) 53.2 (40.1, 66.0) Report an ACT as the antimalarial he/she most commonly recommends for adults Urban Rural Report an ACT as the antimalarial he/she most commonly recommends for children Urban Rural At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was Kenya's first line treatment for uncomplicated malaria. Numbers of providers (N) in this table are the total number of providers eligible for table indicators. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 78 Results Section C: Core Indicators by Type of Public Health Facility Table C1: Availability of antimalarials, among screened outlets, by type of public health facility Proportion of outlets* stocking: Any antimalarial at the time of survey visit Any ACT Artemether Lumefantrine (AL) Quality Assured ACT (QA ACT) QA ACT AL QA ACT with the ‘green leaf’ logo QA ACT without the ‘green leaf’ logo Non-quality-assured ACT (nonQA ACT) Any non-artemisinin therapy Sulfadoxine-Pyrimethamine Any treatment for severe malaria ALL Public Health Facilities Hospital Public Health Centre Public Dispensary % (95% CI) N=44 % (95% CI) N=152 % (95% CI) N=289 % (95% CI) 87.5 98.9 90.7 92.5 (69.9, 95.5) (97.5, 99.5) (87.4, 93.3) (89.5, 94.7) 85.3 81.8 74.0 77.2 (68.9, 93.9) (75.1, 87.0) (68.3, 78.9) (72.7, 81.2) 85.3 81.8 74.0 77.2 (68.9, 93.9) (75.1, 87.0) (68.3, 78.9) (72.7, 81.2) 85.3 81.8 73.8 77.1 (68.9, 93.9) (75.1, 87.0) (68.1, 78.8) (72.6, 81.1) 85.3 81.8 73.8 77.1 (68.9, 93.9) (75.1, 87.0) (68.1, 78.8) (72.6, 81.1) 44.3 24.1 26.0 27.5 (31.0, 58.5) (18.0, 31.6) (20.1, 32.8) (22.1, 33.7) 69.9 69.3 61.7 64.6 (54.6, 81.7) (61.3, 76.4) (54.5, 68.3) (58.8, 69.9) 11.2 2.5 0.9 2.5 (6.3, 19.1) (1.3, 4.7) (0.5, 1.6) (1.7, 3.5) 71.1 77.1 66.6 69.8 (56.1, 82.5) (70.0, 82.9) (60.4, 72.3) (64.2, 74.9) 19.0 12.4 13.6 13.9 (11.9, 28.9) (7.8, 19.1) (8.9, 20.4) (9.7, 19.6) 76.6 84.1 69.7 74.2 (61.1, 87.2) (78.6, 88.4) (63.5, 75.3) (69.5, 78.4) N=485 * The denominator includes outlets that met screening criteria for a full interview. There were 10 outlets that did not complete the interview (were not interviewed or completed a partial interview). Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 79 Table C2: Availability of antimalarials, among outlets stocking at least one antimalarial, by type of public health facility Proportion of outlets* stocking: Any antimalarial at the time of survey visit Any ACT Artemether Lumefantrine (AL) Quality Assured ACT (QA ACT) QA ACT AL QA ACT with the ‘green leaf’ logo QA ACT without the ‘green leaf’ logo Non-quality-assured ACT (nonQA ACT) Any non-artemisinin therapy Sulfadoxine-Pyrimethamine Any treatment for severe malaria ALL Public Health Facilities Hospital Public Health Centre Public Dispensary % (95% CI) N=42 % (95% CI) N=147 % (95% CI) N=268 % (95% CI) 100.0 100.0 100.0 100.0 - - - - 97.4 82.7 81.5 83.5 (92.6, 99.1) (76.0, 87.8) (76.3, 85.8) (79.6, 86.8) 97.4 82.7 81.5 83.5 (92.6, 99.1) (76.0, 87.8) (76.3, 85.8) (79.6, 86.8) 97.4 82.7 81.3 83.4 (92.6, 99.1) (76.0, 87.8) (76.1, 85.6) (79.5, 86.6) 97.4 82.7 81.3 83.4 (92.6, 99.1) (76.0, 87.8) (76.1, 85.6) (79.5, 86.6) 50.6 24.4 28.6 29.8 (35.9, 65.2) (18.2, 31.9) (22.2, 36.0) (24.0, 36.3) 79.8 70.1 68.0 69.8 (66.7, 88.6) (62.1, 77.1) (60.5, 74.6) (64.0, 75.0) 12.8 2.5 1.0 2.7 (7.3, 21.5) (1.3, 4.7) (0.6, 1.8) (1.9, 3.8) 81.2 77.9 73.4 75.5 (69.3, 89.2) (70.8, 83.7) (67.4, 78.7) (70.1, 80.2) 21.7 12.5 15.0 15.0 (13.7, 32.5) (7.9, 19.3) (9.8, 22.4) (10.5, 21.1) 87.5 85.0 76.8 80.2 (76.9, 93.6) (79.5, 89.2) (70.3, 82.2) (75.6, 84.1) N=457 * The denominator includes outlets that met screening criteria for a full interview. There were 9 outlets that did not complete the interview (were not interviewed or completed a partial interview). Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 80 Table C5: Availability of malaria blood testing among antimalarial-stocking outlets*, by type of public health facility Proportion of outlets** that stocked: Any malaria blood testing Microscopic blood tests Rapid diagnostic tests (RDTs) Hospital Public Health Centre Public Dispensary % (95% CI) % (95% CI) % (95% CI) ALL Public Health Facilities % (95% CI) N=43 N=150 N=278 N=471 100.0 100.0 90.5 94.1 N=43 N=150 (84.3, 94.4) N=277 (90.1, 96.5) N=470 100.0 88.3 42.5 60.9 N=43 (78.3, 94.1) N=150 (37.1, 48.1) N=277 (56.8, 64.9) N=470 23.7 68.2 75.9 68.2 (15.4, 34.6) (59.2, 76.1) (69.1, 81.6) (62.7, 73.3) * Blood testing availability is reported among outlets that either had antimalarials in stock on the day of the survey or reportedly stocked antimalarials in the previous 3 months. ** Results in this table are derived using responses captured among outlets with blood testing information. There were no antimalarialstocking outlet with missing information about both availability of microscopy and availability of RDTs, and 3 antimalarial-stocking outlets had partial information about blood testing availability. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 81 Table C12: Provider antimalarial treatment knowledge and practices, by type of public health facility Hospital Public Health Centre Public Dispensary % (95% CI) % (95% CI) % (95% CI) ALL Public Health Facilities % (95% CI) N=43 N=150 N=278 N=471 100.0 97.3 99.1 98.7 - (94.2, 98.7) (97.7, 99.7) (97.5, 99.3) 89.3 96.0 97.1 95.9 (58.6, 98.0) (92.4, 97.9) (95.2, 98.2) (92.9, 97.7) Proportion of providers who: Correctly state the national firstline treatment for uncomplicated malaria Correctly state the first-line dosing regimen for: An adult A two-year old child 75.7 88.9 89.4 87.8 (56.3, 88.3) (83.8, 92.5) (85.8, 92.2) (84.4, 90.6) Report an ACT as the most effective antimalarial medicine for Adults Children 95.3 98.5 96.2 96.7 (87.2, 98.4) (96.7, 99.3) (93.2, 97.9) (94.6, 98.0) 88.7 96.8 94.9 94.7 (77.3, 94.8) (94.2, 98.3) (91.8, 96.8) (92.6, 96.3) Report an ACT as the antimalarial he/she most commonly recommends for: Adults Children 97.9 98.6 98.5 98.5 (88.8, 99.6) (96.9, 99.4) (94.2, 99.6) (96.3, 99.4) 91.3 98.8 98.9 98.0 (79.9, 96.5) (97.2, 99.5) (93.6, 99.8) (95.7, 99.1) At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was Kenya's first line treatment for uncomplicated malaria. Numbers of providers (N) in this table are the total number of providers eligible for table indicators. There were no providers with missing information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 82 Results Section D: Core Indicators across Survey Round: 2010, 2011, 2014 Table D1: Availability of antimalarials, among all screened outlets, by outlet type, across survey round Proportion of outlets* stocking: Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) 2010 N=426 2011 N=442 2014 N=485 2010 N=1,806 2011 N=837 2014 N=1,096 91.7 (84.7, 95.7) 96.8 (92.0, 98.8) 92.5 (89.5, 94.7) ALL Public Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 2010 N=365 2011 N=308 2014 N=453 2010 N=236 2011 N=263 2014 N=503 2010 N=477 2011 N=503 2014 N=572 2010 N=10,669 2011 N=9,424 2014 N=9,950 2010 N=12,901 2011 N=10,546 2014 N=11,580 2010 N=13,897 2011 N=11,383 2014 N=12,676 10.0 (6.3, 15.6) 52.5 (26.3, 77.5) 18.6 (14.2, 24.0) 62.5 (46.9, 75.9) 88.9 (81.3, 93.6) 73.3 (68.5, 77.6) 92.2 (86.2, 95.8) 98.4 (95.9, 99.4) 96.3 (94.2, 97.7) 88.1 (83.9, 91.3) 94.4 (91.1, 96.5) 93.2 (91.7, 94.4) 4.9 (3.4, 7.0) 5.3 (4.1, 6.9) 2.9 (2.1, 4.0) 10.0 (8.5, 11.7) 12.1 (10.7, 13.5) 10.7 (9.8, 11.7) 10.0 (8.5, 11.7) 16.6 (15.2, 18.1) 11.3 (10.4, 12.3) 81.4 (68.5, 89.8) 94.0 (89.6, 96.6) 77.2 (72.7, 81.2) 8.5 (5.1, 13.8) 51.1 (25.8, 75.9) 16.2 (12.2, 21.1) 35.6 (27.6, 44.4) 74.3 (66.9, 80.5) 67.9 (63.6, 71.8) 91.1 (85.8, 94.5) 93.7 (88.6, 96.6) 96.2 (94.1, 97.5) 41.1 (35.0, 47.5) 84.7 (77.1, 90.2) 85.8 (82.9, 88.3) 0.0 1.3 (0.7, 2.2) 0.8 (0.4, 1.4) 2.9 (2.4, 3.5) 7.6 (6.2, 9.1) 8.3 (7.3, 9.3) 3.9 (3.2, 4.6) 12.5 (11.1, 14.0) 8.8 (7.9, 9.8) 81.4 (68.5, 89.8) 94.0 (89.6, 96.6) 77.2 (72.7, 81.2) 8.4 (5.1, 13.6) 51.1 (25.8, 75.8) 16.2 (12.2, 21.1) 32.0 (24.4, 40.6) 73.3 (66.0, 79.6) 66.4 (62.2, 70.3) 89.1 (84.4, 92.5) 92.9 (87.3, 96.1) 94.2 (91.7, 96.0) 39.8 (34.2, 45.6) 83.3 (75.8, 88.9) 83.9 (81.1, 86.3) 0.0 1.3 (0.7, 2.2) 0.8 (0.4, 1.4) 2.8 (2.3, 3.4) 7.5 (6.2, 9.0) 8.1 (7.2, 9.1) 3.7 (3.1, 4.5) 12.4 (11.1, 13.9) 8.7 (7.8, 9.7) 80.4 (66.0, 89.6) 93.9 (89.5, 96.5) 77.1 (72.6, 81.1) 8.2 (5.0, 13.4) 51.0 (25.8, 75.7) 16.1 (12.2, 21.1) 23.3 (17.0, 31.2) 69.4 (62.2, 75.8) 61.2 (57.2, 65.2) 81.4 (76.8, 85.3) 89.7 (84.2, 93.4) 87.1 (84.8, 89.1) 29.1 (24.1, 34.6) 81.5 (73.8, 87.3) 78.5 (76.0, 80.8) 0.0 1.2 (0.7, 2.2) 0.8 (0.4, 1.3) 2.1 (1.7, 2.6) 7.2 (5.9, 8.8) 7.5 (6.7, 8.5) 3.1 (2.6, 3.8) 12.2 (10.9, 13.6) 8.2 (7.4, 9.1) Any antimalarial at the time of survey visit 2010 2011 2014 Any ACT 2010 2011 2014 Artemether Lumefantrine (AL) 2010 2011 2014 Quality Assured ACT (QA ACT) 2010 2011 2014 www.ACTwatch.info Page 83 Table D1: Availability of antimalarials, among all screened outlets, by outlet type, across survey round Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) 1.2 (0.5, 2.7) 66.5 (53.9, 77.1) 27.5 (22.1, 33.7) 0.1 (0.1, 0.3) 35.9 (19.6, 56.2) 7.5 (5.1, 10.8) 80.0 (65.8, 89.3) 62.1 (49.7, 73.0) 64.6 (58.8, 69.9) ALL Public Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 8.4 (5.5, 12.6) 64.6 (57.6, 71.0) 53.9 (50.0, 57.7) 45.7 (32.6, 59.5) 89.5 (83.9, 93.3) 82.7 (80.5, 84.8) 9.1 (4.3, 18.5) 79.1 (71.0, 85.5) 71.0 (67.5, 74.2) 0.0 1.2 (0.7, 2.1) 0.6 (0.4, 1.1) 0.8 (0.5, 1.2) 7.0 (5.7, 8.5) 6.7 (6.0, 7.6) 0.7 (0.4, 1.0) 10.3 (8.9, 11.8) 6.8 (6.0, 7.7) 8.2 (4.9, 13.3) 33.4 (17.2, 54.6) 12.0 (8.8, 16.0) 17.6 (11.7, 25.8) 11.8 (7.6, 17.7) 14.9 (12.3, 18.1) 74.1 (68.2, 79.2) 17.2 (14.4, 20.2) 22.6 (18.0, 27.9) 6.9 (4.1, 11.4) 16.3 (14.1, 18.8) 0.0 0.2 (0.1, 0.4) 1.7 (1.2, 2.2) 0.7 (0.6, 1.0) 1.6 (1.4, 1.9) 2.7 (2.2, 3.4) 4.4 (3.5, 5.5) 2.4 (2.1, 2.8) 3.4 (1.9, 5.9) 6.1 (3.3, 11.0) 2.5 (1.7, 3.5) 0.9 (0.4, 1.9) 3.5 (1.5, 8.0) 2.6 (1.3, 5.2) 26.6 (19.5, 35.2) 29.3 (22.1, 37.7) 36.2 (33.0, 39.6) 90.5 (85.3, 94.0) 86.8 (80.8, 91.1) 84.4 (79.9, 88.1) 25.8 (18.3, 35.1) 37.3 (29.2, 46.2) 46.7 (40.3, 53.1) 0.0 0.1 (0.0, 0.2) 0.1 (0.0, 0.1) 2.1 (1.7, 2.5) 3.4 (2.7, 4.3) 4.5 (3.8, 5.2) 1.9 (1.5, 2.3) 3.4 (2.7, 4.3) 4.3 (3.7, 5.1) 87.3 (78.9, 92.7) 91.3 (85.5, 94.9) 69.8 (64.2, 74.9) 8.2 (5.5, 12.0) 49.5 (25.0, 74.3) 12.4 (9.3, 16.5) 52.0 (37.3, 66.4) 66.8 (60.2, 72.8) 38.1 (33.7, 42.7) 72.9 (67.3, 77.9) 83.4 (75.5, 89.1) 62.0 (57.9, 65.9) 80.0 (75.7, 83.7) 75.4 (67.5, 81.9) 65.6 (62.2, 68.8) 4.9 (3.4, 7.0) 4.5 (3.4, 5.9) 2.3 (1.6, 3.4) 9.3 (7.9, 10.9) 9.8 (8.7, 11.0) 7.2 (6.5, 8.1) 9.1 (7.7, 10.7) 14.3 (12.9, 15.7) 7.6 (6.9, 8.5) QA ACT with “green leaf” logo 2010 2011 2014 QA ACT without “green leaf” logo 2010 2011 2014 Non-quality-assured ACT 2010 2011 2014 Any non-artemisinin therapy 2010 2011 2014 www.ACTwatch.info Page 84 Table D1: Availability of antimalarials, among all screened outlets, by outlet type, across survey round Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) 68.4 (56.8, 78.1) 55.4 (43.3, 66.9) 13.9 (9.7, 19.6) 6.6 (4.3, 9.9) 30.5 (15.9, 50.4) 3.1 (2.2, 4.2) 59.4 (50.9, 67.4) 72.7 (64.6, 79.5) 41.5 (36.1, 47.2) ALL Public Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 26.8 (19.1, 36.2) 37.0 (28.6, 46.3) 18.1 (15.7, 20.8) 31.0 (21.9, 41.8) 64.0 (52.9, 73.8) 50.8 (47.5, 54.1) 68.9 (61.2, 75.7) 53.9 (46.7, 61.0) 53.6 (50.1, 56.9) 3.3 (2.2, 5.0) 2.8 (2.1, 3.9) 1.8 (1.2, 2.6) 6.7 (5.3, 8.3) 6.5 (5.6, 7.5) 5.3 (4.7, 6.0) 6.7 (5.3, 8.3) 9.2 (8.0, 10.6) 5.1 (4.6, 5.8) 4.8 (3.1, 7.5) 39.1 (20.3, 61.9) 7.3 (5.1, 10.3) 19.7 (13.8, 27.4) 32.5 (24.4, 41.7) 12.0 (9.6, 14.9) 36.2 (26.9, 46.7) 38.5 (29.4, 48.5) 20.2 (16.5, 24.5) 38.8 (31.7, 46.3) 43.0 (32.1, 54.6) 24.6 (20.2, 29.5) 0.0 (0.0, 0.2) 0.1 (0.0, 0.2) 0.1 (0.0, 0.4) 2.2 (1.7, 3.0) 3.0 (2.3, 4.1) 1.9 (1.6, 2.2) 2.7 (2.1, 3.3) 7.1 (6.1, 8.3) 2.3 (2.0, 2.7) 0.0 0.0 0.0 - 0.0 0.0 0.0 - 1.1 (0.2, 5.4) 0.5 (0.1, 3.5) 0.1 (0.0, 0.3) 0.9 (0.2, 3.5) 1.2 (0.2, 7.8) 0.0 - 11.9 (2.8, 39.1) 0.0 0.0 - 0.0 0.0 0.0 - 0.5 (0.1, 2.7) 0.0 (0.0, 0.1) 0.0 - 0.4 (0.1, 2.4) 0.0 (0.0, 0.1) 0.0 - 3.6 (1.6, 7.6) 2.5 (1.2, 5.2) 50.8 (45.6, 56.0) 0.4 (0.2, 0.8) 2.1 (1.0, 4.7) 9.4 (6.8, 12.9) 16.3 (10.5, 24.5) 21.4 (15.2, 29.1) 32.2 (29.0, 35.5) 56.5 (36.1, 74.9) 44.5 (30.6, 59.4) 24.3 (20.0, 29.2) 8.0 (5.6, 11.3) 12.8 (7.5, 21.2) 8.7 (6.6, 11.3) 0.0 0.0 0.0 (0.0, 0.1) 1.0 (0.7, 1.4) 1.6 (1.2, 2.2) 1.9 (1.6, 2.2) 0.9 (0.6, 1.3) 1.7 (1.2, 2.3) 2.5 (2.2, 2.8) Sulfadoxine-Pyrimethamine 2010 2011 2014 Oral Quinine 2010 2011 2014 Oral artemisinin monotherapy 2010 2011 2014 Non-oral artemisinin monotherapy 2010 2011 2014 www.ACTwatch.info Page 85 Table D1: Availability of antimalarials, among all screened outlets, by outlet type, across survey round Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) 66.3 (55.1, 75.9) 77.3 (69.2, 83.8) 74.2 (69.5, 78.4) 5.9 (3.8, 9.2) 42.2 (21.3, 66.2) 13.1 (9.9, 17.3) 38.6 (25.0, 54.2) 47.7 (39.2, 56.4) 43.7 (40.3, 47.1) ALL Public Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 61.0 (38.5, 79.6) 48.6 (35.0, 62.3) 26.8 (22.3, 31.9) 22.5 (18.4, 27.3) 25.2 (17.5, 34.8) 15.6 (12.1, 19.9) 0.0 0.0 0.0 (0.0, 0.1) 2.1 (1.6, 2.6) 2.8 (2.2, 3.6) 2.7 (2.4, 3.1) 2.7 (2.2, 3.3) 7.3 (6.1, 8.6) 3.5 (3.1, 3.8) Any treatment for severe malaria 2010 2011 2014 * The denominator includes outlets that met screening criteria for a full interview but did not complete the interview (were not interviewed or completed a partial interview). Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 86 Table D2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type, across survey round Proportion of outlets* stocking: Public Health Facility ALL Public/Not-ForProfit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 2010 N=395 2011 N=428 2014 N=457 2010 N=455 2011 N=470 2014 N=517 2010 N=242 2011 N=272 2014 N=342 2010 N=216 2011 N=258 2014 N=487 2010 N=421 2011 N=475 2014 N=535 2010 N=553 2011 N=379 2014 N=252 2010 N=1,433 2011 N=1,384 2014 N=1,616 2010 N=1,888 2011 N=1,854 2014 N=2,133 88.8 (79.0, 94.3) 97.1 (93.8, 98.7) 83.5 (79.6, 86.8) 85.1 (74.6, 91.8) 97.3 (94.4, 98.7) 86.8 (83.2, 89.8) 56.9 (48.6, 64.9) 83.6 (77.3, 88.4) 92.6 (90.4, 94.3) 98.8 (95.1, 99.7) 95.3 (89.5, 97.9) 99.9 (99.7, 99.9) 46.6 (39.9, 53.5) 89.8 (82.9, 94.1) 92.1 (89.0, 94.3) 0.0 24.2 (14.3, 37.8) 27.0 (15.7, 42.5) 29.3 (24.3, 34.7) 62.8 (53.5, 71.2) 77.1 (69.8, 83.1) 38.6 (33.0, 44.5) 75.1 (68.3, 80.8) 78.3 (71.8, 83.7) 88.8 (79.0, 94.3) 97.0 (93.8, 98.6) 83.5 (79.6, 86.8) 83.5 (72.7, 90.6) 97.2 (94.3, 98.7) 86.8 (83.2, 89.8) 51.1 (43.7, 58.5) 82.5 (76.3, 87.4) 90.5 (88.4, 92.3) 96.6 (90.6, 98.8) 94.4 (88.9, 97.3) 97.8 (96.8, 98.5) 45.1 (39.2, 51.2) 88.3 (81.5, 92.8) 90.0 (87.1, 92.3) 0.0 24.2 (14.3, 37.8) 27.0 (15.7, 42.5) 27.8 (22.5, 33.7) 62.0 (52.9, 70.4) 75.6 (68.5, 81.4) 37.1 (31.3, 43.3) 74.6 (67.9, 80.3) 76.9 (70.6, 82.2) 87.6 (76.2, 94.0) 96.9 (93.7, 98.5) 83.4 (79.5, 86.6) 82.0 (70.8, 89.5) 97.1 (94.2, 98.6) 86.8 (83.1, 89.7) 37.3 (30.8, 44.3) 78.1 (72.1, 83.2) 83.6 (80.7, 86.1) 88.3 (82.7, 92.2) 91.2 (86.3, 94.5) 90.5 (88.8, 92.0) 33.0 (27.5, 39.0) 86.4 (79.2, 91.3) 84.2 (81.8, 86.3) 0.0 23.3 (13.6, 36.9) 26.2 (15.1, 41.6) 21.0 (16.3, 26.7) 59.9 (51.0, 68.2) 70.5 (64.4, 76.0) 31.2 (25.5, 37.6) 73.2 (66.7, 78.8) 72.5 (66.9, 77.5) 1.3 (0.6, 2.9) 68.6 (56.8, 78.4) 29.8 (24.0, 36.3) 1.3 (0.6, 2.7) 68.4 (56.9, 78.0) 40.2 (33.5, 47.3) 13.4 (9.5, 18.5) 72.7 (66.8, 77.9) 73.5 (69.1, 77.4) 49.6 (33.5, 65.7) 91.0 (85.9, 94.3) 85.9 (83.9, 87.7) 10.4 (4.8, 21.1) 83.8 (76.1, 89.4) 76.1 (72.6, 79.4) 0.0 22.8 (13.4, 36.1) 21.4 (12.9, 33.4) 7.7 (4.9, 11.9) 58.0 (49.2, 66.3) 63.0 (57.6, 68.2) 6.7 (4.4, 10.0) 61.7 (54.1, 68.8) 60.3 (55.5, 64.9) Any ACT 2010 2011 2014 Artemether Lumefantrine (AL) 2010 2011 2014 Quality Assured ACT (QA ACT) 2010 2011 2014 QA ACT with “green leaf” logo 2010 2011 2014 www.ACTwatch.info Page 87 Table D2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type, across survey round Public Health Facility ALL Public/Not-ForProfit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 87.2 (76.0, 93.6) 64.1 (50.8, 75.5) 69.8 (64.0, 75.0) 81.3 (70.2, 88.9) 63.5 (50.8, 74.6) 64.2 (56.7, 71.2) 28.2 (21.3, 36.4) 13.2 (8.5, 20.0) 20.4 (17.2, 23.9) 80.3 (73.5, 85.7) 17.8 (15.1, 20.8) 25.7 (20.8, 31.2) 7.3 (4.3, 12.2) 17.5 (15.1, 20.2) 0.0 5.5 (2.2, 13.3) 16.7 (12.0, 22.7) 6.0 (4.5, 8.0) 15.4 (13.3, 17.8) 27.5 (21.8, 34.0) 26.5 (21.6, 32.1) 21.3 (18.5, 24.5) 3.7 (2.0, 6.6) 6.3 (3.4, 11.6) 2.7 (1.9, 3.8) 8.8 (4.9, 15.5) 6.6 (3.8, 11.3) 14.0 (7.9, 23.5) 42.6 (34.8, 50.7) 33.0 (24.4, 42.9) 49.4 (44.8, 54.0) 98.1 (93.6, 99.5) 88.3 (81.9, 92.6) 87.7 (84.2, 90.5) 29.3 (20.5, 39.9) 39.6 (30.8, 49.1) 50.1 (43.2, 57.0) 0.0 1.2 (0.4, 3.9) 2.0 (0.7, 5.2) 20.8 (17.1, 25.1) 28.3 (22.2, 35.4) 41.6 (36.0, 47.5) 18.8 (15.8, 22.3) 20.6 (16.3, 25.6) 38.3 (33.1, 43.7) 95.2 (92.0, 97.2) 94.3 (88.5, 97.2) 75.5 (70.1, 80.2) 81.7 (55.2, 94.2) 94.2 (89.0, 97.1) 66.8 (59.4, 73.4) 83.2 (73.2, 90.0) 75.1 (69.5, 80.0) 52.3 (47.5, 57.0) 79.0 (71.9, 84.8) 84.8 (77.3, 90.1) 64.3 (60.6, 67.9) 90.8 (87.5, 93.3) 79.9 (72.3, 85.8) 70.3 (66.9, 73.6) 100.0 84.0 (75.7, 89.9) 80.9 (68.6, 89.1) 93.4 (91.0, 95.2) 81.3 (77.4, 84.6) 67.6 (63.4, 71.6) 91.4 (86.4, 94.7) 85.9 (82.5, 88.7) 67.5 (63.7, 71.1) 74.6 (65.2, 82.1) 57.2 (45.2, 68.5) 15.0 (10.5, 21.1) 65.4 (47.7, 79.6) 58.0 (46.4, 68.7) 16.5 (12.6, 21.3) 42.9 (31.9, 54.6) 41.7 (32.2, 51.8) 24.7 (21.7, 28.0) 33.6 (24.8, 43.7) 65.1 (54.0, 74.7) 52.8 (49.4, 56.2) 78.2 (70.9, 84.2) 57.1 (49.4, 64.5) 57.5 (54.0, 60.8) 68.5 (56.2, 78.7) 53.5 (45.4, 61.4) 62.0 (48.0, 74.3) 67.0 (59.0, 74.1) 53.8 (49.0, 58.5) 49.6 (45.5, 53.6) 66.7 (59.0, 73.7) 55.3 (50.2, 60.3) 45.6 (41.9, 49.3) QA ACT without “green leaf” logo 2010 2011 2014 Non-Quality Assured ACT (non-QA ACT) 2010 2011 2014 Any non-artemisinin therapy 2010 2011 2014 Sulfadoxine-Pyrimethamine 2010 2011 2014 www.ACTwatch.info Page 88 Table D2: Availability of antimalarials, among outlets stocking at least one antimalarial, by outlet type, across survey round Public Health Facility ALL Public/Not-ForProfit** Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 64.7 (56.5, 72.2) 75.1 (68.1, 80.9) 44.9 (39.0, 50.9) 48.0 (34.9, 61.4) 74.5 (67.9, 80.1) 39.2 (31.9, 47.0) 31.6 (23.7, 40.6) 36.5 (28.5, 45.5) 16.3 (13.3, 19.8) 39.3 (27.8, 52.0) 39.2 (30.2, 49.0) 21.0 (17.3, 25.2) 44.0 (35.6, 52.8) 45.5 (34.4, 57.1) 26.4 (21.7, 31.7) 0.7 (0.1, 5.2) 1.1 (0.3, 3.3) 4.0 (1.1, 13.1) 22.6 (17.0, 29.2) 25.2 (19.5, 32.0) 17.8 (15.5, 20.4) 26.8 (22.0, 32.3) 42.8 (38.0, 47.8) 20.4 (17.8, 23.3) 0.0 0.0 0.0 - 0.0 0.0 0.0 - 1.8 (0.4, 8.4) 0.6 (0.1, 4.0) 0.2 (0.1, 0.4) 1.0 (0.3, 3.7) 1.2 (0.2, 7.9) 0.0 - 13.5 (3.1, 42.9) 0.0 0.0 - 0.0 0.0 0.0 - 5.2 (1.0, 23.9) 0.2 (0.1, 1.0) 0.0 (0.0, 0.1) 4.4 (0.8, 20.7) 0.2 (0.0, 0.6) 0.0 (0.0, 0.1) 3.9 (1.7, 8.7) 2.6 (1.3, 5.3) 54.9 (49.0, 60.7) 4.2 (2.3, 7.5) 4.1 (2.3, 7.0) 50.7 (43.9, 57.6) 26.1 (19.1, 34.7) 24.0 (17.0, 32.8) 43.9 (39.8, 48.1) 61.3 (36.2, 81.6) 45.3 (31.1, 60.3) 25.3 (21.1, 30.0) 9.1 (6.4, 12.7) 13.6 (7.9, 22.5) 9.3 (7.1, 12.2) 0.0 0.0 0.8 (0.3, 2.4) 9.6 (6.5, 13.9) 13.5 (9.8, 18.4) 17.8 (15.3, 20.6) 8.7 (5.9, 12.6) 10.1 (7.6, 13.4) 21.8 (19.3, 24.5) 72.3 (61.5, 81.0) 79.9 (70.7, 86.7) 80.2 (75.6, 84.1) 59.1 (43.1, 73.4) 80.2 (72.0, 86.5) 70.6 (63.2, 77.0) 61.7 (47.4, 74.3) 53.7 (45.3, 62.0) 59.6 (55.3, 63.7) 66.2 (37.9, 86.2) 49.4 (35.6, 63.3) 27.9 (23.5, 32.7) 25.6 (21.1, 30.6) 26.7 (18.6, 36.6) 16.8 (13.0, 21.4) 0.0 0.0 1.2 (0.4, 3.1) 20.9 (15.8, 27.1) 23.3 (18.7, 28.6) 25.2 (22.1, 28.6) 27.3 (22.0, 33.4) 43.6 (37.9, 49.5) 30.7 (27.5, 34.2) Oral Quinine 2010 2011 2014 Oral artemisinin monotherapy 2010 2011 2014 Non-oral artemisinin monotherapy 2010 2011 2014 Any treatment for severe malaria 2010 2011 2014 * Antimalarial‐stocking outlets have at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 89 Table D3: Antimalarial market composition, across survey round Outlet type, among outlets with at least 1 antimalarial in stock on the day of the survey:* 2010, N=1,471 outlets 2011, N=1,348 outlets 2014, N=1,501 outlets Public Health Facility ALL Public Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private % % % % % % % 11.2 17.2 12.0 2.5 30.6 37.5 82.8 (8.3, 15.1) (11.7, 24.6) (8.3, 17.1) (1.4, 4.7) (18.9, 45.5) (27.8, 48.3) (75.4, 88.3) 13.0 16.4 18.8 3.3 30.1 31.5 83.6 (10.2, 16.3) (13.3, 20.0) (14.5, 24.0) (1.9, 5.7) (24.9, 35.9) (24.3, 39.6) (80.0, 86.7) 9.5 14.0 21.4 11.8 33.0 19.8 86.0 (7.9, 11.4) (11.7, 16.8) (19.3, 23.6) (8.6, 16.0) (28.3, 38.0) (14.5, 26.4) (83.2, 88.3) * Excluding booster sample outlets. Outlets with at least one antimalarial in stock on the day of the survey, verified by presence of at least one antimalarial recorded in the antimalarial audit sheet. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 90 Table D4: Price of tablet formulation antimalarials in 2010 USD, by outlet type, across survey round Private For-Profit Facility Median price of a tablet AETD*: Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $3.45 [0.92-5.18] (308) $0.58 [0.46-2.30] (479) $2.63 [1.58-5.25] (655) $4.90 [3.24-7.25] (1,173) $3.45 [0.61-5.18] (1,363) $3.94 [1.84-6.56] (2,115) $4.03 [2.30-5.83] (702) $0.81 [0.46-3.68] (1,356) $2.63 [1.40-5.25] (1,432) $0.46 [0.46-0.46] (114) $1.97 [1.31-3.94] (84) $4.03 [2.30-6.10] (2,183) $0.92 [0.46-4.03] (3,312) $2.63 [1.58-5.25] (4,286) $1.15 [0.00-3.45] (138) $0.58 [0.46-1.15] (342) $1.97 [1.31-2.63] (433) $4.61 [1.15-5.99] (331) $0.61 [0.46-1.38] (671) $1.58 [1.31-2.10] (889) $2.30 [1.38-5.53] (273) $0.58 [0.46-0.92] (882) $1.58 [1.31-2.10] (818) $0.46 [0.46-0.46] (111) $1.40 [1.31-1.97] (69) $2.30 [1.15-5.53] (742) $0.52 [0.46-0.92] (2,006) $1.75 [1.31-2.63] (2,209) $1.15 [0.92-1.38] (39) $0.58 [0.46-1.15] (303) $1.97 [1.31-2.63] (360) $0.92 [0.69-1.15] (98) $0.61 [0.46-1.20] (641) $1.58 [1.31-2.10] (784) $1.15 [0.92-2.30] (108) $0.52 [0.46-0.92] (840) $1.58 [1.31-2.10] (725) $0.46 [0.46-0.46] (108) $1.31 [1.31-1.97] (61) $1.15 [0.81-1.73] (245) $0.46 [0.46-0.92] (1,892) $1.75 [1.31-2.63] (1,930) $1.15 [0.00-4.61] (99) $0.00 [0.00-0.92] (39) $1.97 [1.31-2.63] (71) $5.76 [4.03-6.91] (232) $2.30 [1.15-11.05] (30) $1.40 [1.31-2.10] (105) $3.45 [2.30-5.76] (165) $0.69 [0.46-2.30] (42) $1.58 [1.31-1.97] (92) $0.46 [0.46-0.69] (3) $1.97 [1.31-1.97] (8) $3.45 [1.84-5.76] (496) $0.58 [0.00-1.84] (114) $1.58 [1.31-1.97] (276) Any ACT 2010 2011 2014 Quality-assured ACT (QA ACT) 2010 2011 2014 QA ACT with “green leaf” logo 2010 2011 2014 QA ACT without “green leaf” logo 2010 2011 2014 www.ACTwatch.info Page 91 Table D4: Price of tablet formulation antimalarials in 2010 USD, by outlet type, across survey round Private For-Profit Facility Median price of a tablet AETD*: Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $4.53 [3.22-6.45] (170) $4.61 [3.45-6.91] (137) $5.25 [3.94-6.56] (222) $5.07 [3.68-9.21] (842) $5.18 [4.03-8.63] (692) $5.61 [3.94-10.59] (1,226) $4.61 [3.45-6.33] (429) $4.61 [4.03-5.76] (474) $5.25 [4.07-9.19] (614) $0.46 [0.46-0.46] (3) $6.56 [3.94-13.13] (15) $4.61 [3.45-6.91] (1,441) $4.61 [3.80-7.25] (1,306) $5.25 [3.94-8.40] (2,077) $0.81 [0.40-1.21] (109) $0.58 [0.35-0.92] (116) $0.66 [0.53-1.31] (97) $0.69 [0.35-1.04] (175) $0.92 [0.52-1.73] (268) $0.79 [0.66-1.97] (480) $0.69 [0.46-1.04] (533) $0.58 [0.40-1.15] (395) $0.66 [0.66-1.31] (481) $0.35 [0.35-0.46] (417) $0.35 [0.35-0.46] (198) $0.39 [0.39-0.53] (195) $0.46 [0.35-0.86] (1,235) $0.46 [0.35-1.04] (977) $0.66 [0.46-1.05] (1,253) $1.15 [0.69-3.45] (98) $0.46 [0.46-0.69] (227) $1.84 [1.31-1.97] (255) $4.84 [1.15-5.99] (286) $0.46 [0.46-0.52] (321) $1.31 [1.31-1.97] (504) $2.53 [1.15-5.76] (238) $0.46 [0.46-0.58] (533) $1.31 [1.31-1.97] (488) $0.46 [0.46-0.46] (95) $1.31 [1.31-1.97] (42) $2.53 [1.15-5.76] (622) $0.46 [0.46-0.58] (1,176) $1.31 [1.31-1.97] (1,289) Non-quality assured ACT 2010 2011 2014 Sulfadoxine-Pyrimethamine 2010 2011 2014 Pre-packaged adult QA AL 2010 2011 2014 www.ACTwatch.info Page 92 Table D4: Price of tablet formulation antimalarials in 2010 USD, by outlet type, across survey round Private For-Profit Facility Median price of a tablet AETD*: Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $0.00 [0.00-0.66] (11) $0.53 [0.00-0.66] (34) $0.79 [0.66-1.31] (67) $1.97 [1.58-2.63] (13) $0.53 [0.39-0.53] (131) $0.66 [0.53-1.05] (171) $0.66 [0.53-0.66] (9) $0.53 [0.39-0.53] (116) $0.66 [0.66-1.05] (134) $0.53 [0.20-0.53] (7) $0.66 [0.66-1.31] (6) $0.66 [0.53-1.97] (33) $0.53 [0.39-0.53] (288) $0.66 [0.66-1.31] (378) Pre-packaged Pediatric QA AL 2010 2011 2014 * AETD - adult equivalent treatment dose - is or the number of milligrams required to treat a 60kg adult (see Annex 11). Information provided by the respondent about price for a specific amount of antimalarial drug (e.g. price per tablet or price per specific package size) was converted to the price per AETD. Figures in this table are derived using audited products with price information. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 93 Table D5: Availability of malaria blood testing among antimalarial-stocking outlets*, by outlet type, across survey round Proportion of outlets*** stocking Public Health Facility % (95% CI) % (95% CI) Private For-Profit Facility % (95% CI) 2010 N=404 2011 N=432 2014 N=471 2010 N=506 2011 N=477 2014 N=573 45.5 (39.0, 52.1) 55.4 (48.2, 62.4) 94.1 (90.1, 96.5) ALL Public Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 2010 N=270 2011 N=281 2014 N=375 2010 N=213 2011 N=256 2014 N=490 2010 N=444 2011 N=491 2014 N=556 2010 N=1,100 2011 N=575 2014 N=405 2010 N=2,030 2011 N=1,603 2014 N=1,826 2010 N=2,536 2011 N=2,080 2014 N=2,399 31.8 (20.9, 45.2) 57.2 (50.5, 63.7) 73.3 (53.0, 86.9) 52.8 (41.2, 64.1) 44.5 (34.7, 54.7) 74.3 (70.1, 78.0) 12.7 (7.5, 20.7) 18.0 (11.5, 27.1) 21.0 (18.0, 24.4) 10.5 (7.7, 14.1) 7.1 (4.8, 10.6) 16.2 (13.1, 19.7) 0.0 0.0 0.0 - 9.0 (7.4, 10.9) 10.4 (8.1, 13.3) 25.3 (21.4, 29.6) 12.7 (10.7, 15.0) 25.5 (22.1, 29.3) 31.7 (28.1, 35.5) 2010 N=404 2011 N=432 2014 N=470 2010 N=506 2011 N=477 2014 N=571 2010 N=270 2011 N=280 2014 N=375 2010 N=213 2011 N=256 2014 N=490 2010 N=443 2011 N=488 2014 N=555 2010 N=1,098 2011 N=571 2014 N=403 2010 N=2,027 2011 N=1,595 2014 N=1,823 2010 N=2,533 2011 N=2,072 2014 N=2,394 40.5 (33.6, 47.8) 41.6 (33.2, 50.5) 60.9 (56.8, 64.9) 29.5 (19.6, 41.7) 44.5 (36.0, 53.3) 47.3 (33.5, 61.6) 48.5 (37.7, 59.4) 40.2 (30.4, 50.8) 61.1 (56.7, 65.4) 7.7 (2.9, 19.2) 12.2 (6.3, 22.5) 8.2 (6.5, 10.4) 8.9 (5.8, 13.3) 6.0 (3.8, 9.2) 5.7 (4.1, 7.7) 0.0 0.0 0.0 - 7.9 (6.4, 9.8) 8.9 (6.9, 11.4) 17.4 (14.8, 20.5) 11.4 (9.7, 13.5) 20.4 (17.5, 23.6) 21.5 (18.7, 24.4) 2010 N=403 2011 N=432 2014 N=470 2010 N=505 2011 N=477 2014 N=571 2010 N=269 2011 N=281 2014 N=375 2010 N=213 2011 N=256 2014 N=490 2010 N=443 2011 N=491 2014 N=555 2010 N=1,091 2011 N=575 2014 N=403 2010 N=2,019 2011 N=1,603 2014 N=1,823 2010 N=2,524 2011 N=2,080 2014 N=2,394 6.0 (2.9, 12.1) 19.4 (9.9, 34.4) 68.2 (62.7, 73.3) 5.1 (2.3, 10.9) 18.4 (9.6, 32.3) 51.7 (39.7, 63.5) 6.7 (3.2, 13.6) 6.7 (3.7, 11.8) 29.2 (25.7, 33.0) 5.6 (3.6, 8.5) 6.7 (3.2, 13.6) 15.0 (11.8, 18.9) 1.9 (0.5, 6.5) 1.8 (0.8, 3.7) 12.3 (10.2, 14.8) 0.0 0.0 0.0 - 1.4 (0.8, 2.5) 2.1 (1.3, 3.4) 12.6 (10.5, 15.0) 2.0 (1.3, 3.0) 7.4 (4.2, 12.7) 17.8 (15.7, 20.1) Any malaria blood testing 2010 2011 2014 Microscopic blood tests 2010 2011 2014 Rapid diagnostic tests (RDTs) 2010 2011 2014 * Blood testing availability is reported among outlets that either had antimalarials in stock on the day of the survey or reportedly stocked antimalarials in the previous 3 months. ** Results in this table are derived using responses captured among outlets with blood testing information. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 94 Table D7: Price of malaria blood testing in 2010 USD, by outlet type, across survey round Private For-Profit Facility Total median price to consumers:* Registered Pharmacy Unregistered Pharmacy ALL Private Median [IQR] Median [IQR] Median [IQR] Median [IQR] (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) (N of Antimalarials) $0.66 [0.66-1.31] (159) $0.58 [0.58-1.15] (157) $1.31 [0.66-1.31] (263) $0.66 [0.53-1.31] (27) $1.15 [0.58-1.15] (26) $1.31 [1.31-1.31] (55) $0.66 [0.66-1.31] (34) $0.58 [0.58-0.92] (31) $1.31 [1.31-1.31] (30) $0.66 [0.66-1.31] (220) $0.58 [0.58-1.15] (214) $1.31 [0.66-1.31] (348) $0.66 [0.66-1.31] (160) $0.58 [0.46-0.81] (156) $1.31 [0.66-1.31] (263) $0.66 [0.53-1.31] (26) $0.58 [0.58-1.15] (25) $1.31 [1.31-1.31] (55) $0.66 [0.66-1.31] (34) $0.58 [0.58-0.92] (31) $1.31 [1.31-1.31] (30) $0.66 [0.66-1.31] (220) $0.58 [0.58-1.15] (212) $1.31 [0.66-1.31] (348) $0.00 [0.00-1.31] (21) $0.58 [0.35-1.15] (23) $1.31 [1.31-1.97] (134) $0.92 [0.92-2.63] (16) $1.73 [1.15-1.73] (29) $1.31 [1.31-1.31] (55) $1.31 [1.31-1.31] (8) $1.15 [0.58-1.73] (15) $1.31 [1.31-1.97] (59) $1.31 [0.00-1.31] (45) $1.15 [0.58-1.73] (67) $1.31 [1.31-1.97] (248) $0.00 [0.00-1.31] (21) $0.58 [0.23-1.15] (23) $1.31 [1.31-1.97] (133) $0.92 [0.92-2.63] (16) $1.15 [1.15-1.73] (28) $1.31 [1.31-1.31] (53) $1.31 [1.31-1.31] (8) $1.15 [0.58-1.38] (15) $1.31 [1.31-1.31] (59) $1.31 [0.00-1.31] (45) $1.15 [0.58-1.38] (66) $1.31 [1.31-1.97] (245) Microscopic blood tests Adult 2010 2011 2014 Child under age five 2010 2011 2014 Rapid diagnostic tests (RDTs) Adult 2010 2011 2014 Child under five 2010 2011 2014 * Total price to the consumer including consultation and/or service fees. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 95 Table D8: Antimalarial market share, across survey round AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed: Public Health Facility TOTAL Public/Not ForProfit Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private ANTI-MALARIAL TOTAL* % % % % % % % % 4.7 2.5 1.9 2.3 4.4 4.1 0.0 0.1 9.2 6.3 3.4 1.4 2.9 33.2 30.2 0.8 0.2 40.6 0.0 0.0 0.0 0.0 6.1 5.3 0.0 0.0 6.1 15.3 8.1 4.3 7.1 50.2 45.2 0.9 0.5 67.0 33.4 25.8 4.4 7.6 65.0 58.9 0.9 0.6 100.0 3.2 2.6 2.6 0.6 2.5 2.4 0.0 0.0 5.7 28.1 25.8 25.0 2.3 9.2 7.9 0.0 0.1 37.4 2.5 2.3 2.3 0.2 2.2 1.9 0.0 0.0 4.7 43.8 39.4 37.4 4.4 19.2 16.9 0.0 0.2 63.3 61.7 57.3 50.6 4.5 38.0 34.3 0.0 0.2 100.0 27.4 17.4 14.1 10.0 12.6 11.8 0.0 0.6 40.6 20.8 16.3 14.1 4.5 9.5 9.0 0.0 0.2 30.5 2.3 1.8 1.4 0.5 2.6 2.5 0.0 0.0 4.9 60.0 42.3 35.1 17.7 26.5 24.9 0.0 1.2 87.7 70.0 51.7 39.9 18.3 28.6 26.4 0.0 1.4 100.0 2010 1. Any ACT 15.9 18.1 4.3 Quality Assured ACT (QA ACT) 15.8 17.7 2.3 QA ACT with the ‘green leaf’ logo 0.1 0.1 0.9 Non-quality-assured ACT 0.1 0.4 2.0 2. Any non-artemisinin therapy 10.4 14.8 6.4 Sulfadoxine-Pyrimethamine 9.5 13.7 5.7 3. Oral artemisinin monotherapy 0.0 0.0 0.1 4. Non-oral artemisinin monotherapy 0.0 0.1 0.2 OUTLET TYPE TOTAL*** 26.4 33.0 11.0 2011 1. Any ACT 15.6 17.9 10.1 Quality Assured ACT (QA ACT) 15.6 17.9 8.7 QA ACT with the ‘green leaf’ logo 12.0 13.1 7.6 Non-quality-assured ACT 0.0 0.0 1.4 2. Any non-artemisinin therapy 18.2 18.8 5.3 Sulfadoxine-Pyrimethamine 17.1 17.5 4.7 3. Oral artemisinin monotherapy 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.0 0.0 0.1 OUTLET TYPE TOTAL*** 33.9 36.7 15.5 2014 1. Any ACT 7.5 10.0 9.6 Quality Assured ACT (QA ACT) 7.4 9.4 6.9 QA ACT with the ‘green leaf’ logo 3.8 4.8 5.5 Non-quality-assured ACT 0.1 0.6 2.7 2. Any non-artemisinin therapy 1.8 2.1 1.8 Sulfadoxine-Pyrimethamine 1.4 1.5 1.6 3. Oral artemisinin monotherapy 0.0 0.0 0.0 4. Non-oral artemisinin monotherapy 0.1 0.2 0.3 OUTLET TYPE TOTAL*** 9.4 12.3 11.7 * Row sum – market share for the specified antimalarial medicine. *** Column sum (within each survey round) – market share for the specified outlet type. Categories 1 through 4 sum to 100% in the far-right column – antimalarial total column (within in survey round). Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 96 Table D9: Antimalarial market share, across outlet type, across survey round Public Health Facility TOTAL Public / Not-ForProfit Private For-Profit Facility Registered Pharmacy Unregistered Pharmacy General Retailer TOTAL Private % % % % % % % 2010 1. Any ACT Quality Assured ACT (QA ACT) QA ACT with the ‘green leaf’ logo Non-quality-assured ACT 2. Any non-artemisinin therapy Sulfadoxine-Pyrimethamine 3. Oral artemisinin monotherapy 4. Non-oral artemisinin monotherapy 60.4 60.0 0.3 0.4 39.5 35.9 0.0 0.1 54.9 53.6 0.3 1.3 44.9 41.3 0.0 0.2 39.0 20.6 8.5 18.4 58.4 51.4 1.1 1.4 51.3 26.7 20.5 24.6 47.2 44.0 0.0 1.5 15.4 8.4 3.5 7.0 82.0 74.4 2.0 0.6 0.0 0.0 0.0 0.0 100.0 87.0 0.0 0.0 22.8 12.1 6.4 10.7 75.0 67.6 1.4 0.8 2011 1. Any ACT Quality Assured ACT (QA ACT) QA ACT with the ‘green leaf’ logo Non-quality-assured ACT 2. Any non-artemisinin therapy Sulfadoxine-Pyrimethamine 3. Oral artemisinin monotherapy 4. Non-oral artemisinin monotherapy 46.1 46.1 35.4 0.1 53.9 50.4 0.0 0.0 48.8 48.7 35.8 0.1 51.1 47.6 0.0 0.0 64.9 56.1 49.0 8.8 34.0 30.2 0.3 0.8 55.9 45.1 45.0 10.8 43.6 42.3 0.0 0.5 75.1 69.0 66.8 6.1 24.7 21.1 0.0 0.2 52.8 49.1 48.5 3.7 47.2 40.2 0.0 0.0 69.2 62.2 59.1 7.0 30.4 26.6 0.1 0.4 81.7 58.9 47.3 22.7 15.3 13.4 0.1 2.9 67.4 42.8 34.8 24.6 31.1 29.2 0.0 1.5 68.1 53.3 46.1 14.9 31.1 29.4 0.0 0.7 46.7 36.0 28.5 10.7 53.3 51.8 0.0 0.0 68.4 48.2 40.0 20.2 30.2 28.4 0.0 1.3 AETDs sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/ distributed: 2014 1. Any ACT 79.5 81.2 Quality Assured ACT (QA ACT) 78.9 76.6 QA ACT with the ‘green leaf’ logo 41.0 39.2 Non-quality-assured ACT 0.6 4.7 2. Any non-artemisinin therapy 19.4 17.0 Sulfadoxine-Pyrimethamine 15.4 12.1 3. Oral artemisinin monotherapy 0.0 0.0 4. Non-oral artemisinin monotherapy 1.1 1.7 Categories 1 through 4 sum to 100% within each column (within each survey round). Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. www.ACTwatch.info Page 97 Table D12: Provider antimalarial treatment knowledge and practices, by outlet type, across survey round Proportion of providers who: Public Health Facility % (95% CI) ALL Public / Not forprofit % (95% CI) Private for-profit HF % (95% CI) 2010 N=407 2011 N=432 2014 N=471 2010 N=509 2011 N=477 2014 N=573 96.7 (94.2, 98.2) 97.6 (95.0, 98.9) 98.7 (97.5, 99.3) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 2010 N=270 2011 N=282 2014 N=375 2010 N=216 2011 N=259 2014 N=492 2010 N=444 2011 N=492 2014 N=557 2010 N=1,112 2011 N=576 2014 N=408 2010 N=2,045 2011 N=1,609 2014 N=1,832 2010 N=2,554 2011 N=2,086 2014 N=2,405 83.0 (71.2, 90.6) 97.0 (94.6, 98.4) 96.1 (93.9, 97.5) 77.3 (68.0, 84.5) 86.4 (77.3, 92.2) 92.8 (90.9, 94.3) 97.3 (92.1, 99.1) 90.9 (85.1, 94.6) 96.2 (93.9, 97.6) 61.9 (48.8, 73.4) 84.5 (78.4, 89.1) 91.0 (88.9, 92.7) 15.5 (11.1, 21.1) 29.9 (20.5, 41.2) 29.3 (22.9, 36.6) 36.8 (32.6, 41.2) 58.6 (50.6, 66.2) 71.5 (64.4, 77.7) 44.3 (39.5, 49.1) 71.0 (65.1, 76.3) 74.8 (68.4, 80.3) 68.1 (57.1, 77.4) 85.5 (78.9, 90.3) 95.9 (92.9, 97.7) 43.7 (30.1, 58.3) 85.8 (79.8, 90.3) 88.4 (84.1, 91.6) 31.0 (24.9, 37.9) 69.8 (61.9, 76.7) 87.8 (85.7, 89.7) 85.1 (77.4, 90.5) 80.0 (73.1, 85.4) 89.9 (87.9, 91.6) 27.0 (22.5, 32.1) 76.9 (70.1, 82.5) 86.2 (83.8, 88.3) 11.8 (7.6, 18.0) 17.3 (12.9, 22.6) 12.9 (9.8, 16.9) 44.1 (38.0, 50.5) 64.2 (57.0, 70.8) 17.9 (14.7, 21.7) 57.5 (51.8, 63.1) 67.4 (61.0, 73.3) 64.4 (54.0, 73.6) 83.7 (76.1, 89.2) 42.8 (32.3, 54.0) 83.3 (76.7, 88.3) 20.4 (14.1, 28.6) 49.4 (41.7, 57.1) 68.8 (54.7, 80.1) 63.7 (54.3, 72.2) 14.5 (10.9, 19.0) 52.6 (45.8, 59.4) 5.4 (3.0, 9.6) 8.0 (10.7, 17.1) 30.0 (24.7, 35.9) 13.6 (15.0, 24.9) 47.1 (41.6, 52.8) 87.8 (84.4, 90.6) 79.1 (72.4, 84.4) 73.0 (69.4, 76.3) 81.1 (78.6, 83.3) 73.9 (70.6, 76.9) 10.1 (7.0, 14.3) 53.2 (47.0, 59.3) 56.7 (51.0, 62.2) www.ACTwatch.info Page 98 Correctly state the national first-line treatment for uncomplicated malaria 2010 2011 2014 Correctly state the first-line dosing regimen for*: An adult 2010 2011 2014 A two-year old child 2010 2011 2014 Table D12: Provider antimalarial treatment knowledge and practices, by outlet type, across survey round Proportion of providers who: Public Health Facility % (95% CI) ALL Public / Not forprofit % (95% CI) Private for-profit HF % (95% CI) 2010 N=407 2011 N=432 2014 N=471 2010 N=509 2011 N=477 2014 N=573 84.6 (79.6, 88.5) 95.7 (92.5, 97.5) 96.7 (94.6, 98.0) 87.7 (83.0, 91.3) 95.3 (91.0, 97.6) 94.7 (92.6, 96.3) Registered Pharmacy Unregistered Pharmacy General Retailer ALL Private ALL Outlets % (95% CI) % (95% CI) % (95% CI) % (95% CI) % (95% CI) 2010 N=270 2011 N=282 2014 N=375 2010 N=216 2011 N=259 2014 N=492 2010 N=444 2011 N=492 2014 N=557 2010 N=1,112 2011 N=576 2014 N=408 2010 N=2,045 2011 N=1,609 2014 N=1,832 2010 N=2,554 2011 N=2,086 2014 N=2,405 66.5 (57.7, 74.4) 94.8 (91.6, 96.8) 93.9 (90.6, 96.2) 50.6 (42.2, 58.8) 82.7 (76.1, 87.8) 89.2 (86.7, 91.3) 89.4 (83.7, 93.3) 89.8 (81.4, 94.7) 95.0 (93.3, 96.2) 38.3 (26.0, 52.3) 88.1 (81.5, 92.6) 87.6 (85.7, 89.3) 4.7 (2.9, 7.5) 25.7 (16.8, 37.2) 29.1 (19.7, 40.7) 21.0 (17.6, 24.8) 56.8 (48.3, 64.9) 69.3 (61.2, 76.4) 28.3 (24.0, 33.1) 69.0 (62.5, 74.9) 72.6 (65.3, 78.9) 68.9 (55.5, 79.7) 94.7 (90.5, 97.1) 91.6 (88.6, 93.8) 42.1 (34.1, 50.4) 79.2 (72.1, 84.9) 87.3 (84.5, 89.6) 88.2 (82.3, 92.3) 96.3 (92.3, 98.3) 96.3 (94.8, 97.4) 35.3 (26.4, 45.3) 75.8 (67.1, 82.8) 85.6 (83.0, 87.8) 3.9 (2.4, 6.5) 18.6 (12.1, 27.5) 21.9 (14.4, 31.8) 18.8 (15.5, 22.6) 50.2 (42.4, 57.9) 65.8 (57.7, 73.2) 26.8 (22.2, 32.0) 64.5 (58.4, 70.2) 69.3 (62.1, 75.7) www.ACTwatch.info Page 99 Report an ACT as the most effective antimalarial medicine For adults 2010 2011 2014 For children 2010 2011 2014 At the time of the 2014 Kenya ACTwatch outlet survey, artemether lumefantrine was Kenya's first line treatment for uncomplicated malaria. Numbers of providers (N) in this table are the total number of providers eligible for table indicators. * In 2010 and 2011, this question was only administered in QA ACT-stocking outlets. Source: ACTwatch Outlet Survey, Kenya, 2010, 2011, 2014. Annex 1: ACTwatch Background ACTwatch is a multi-country research project implemented by PSI (www.psi.org). Standardized tools and approaches are employed to provide comparable data across countries and over time. Project countries include: Benin, Cambodia, the Democratic Republic of Congo, Kenya, Laos, Madagascar, Myanmar, Nigeria, Tanzania (currently mainland only, previous work in Zanzibar), Thailand, Uganda, Vietnam, and Zambia. The project was launched in 2008 with funding from the Bill and Melinda Gates Foundation (BMGF), and is currently funded through 2016 by the BMGF, UNITAID, and DFID. ACTwatch is designed to provide timely, relevant, and high quality antimalarial market evidence.2 The goal of providing this market evidence is to inform and monitor national and global policy, strategy, and funding decisions for improving malaria case management. ACTwatch is monitoring antimalarial markets in the context of policy shifts and investments in the scale-up of first-line ACT and blood testing using RDTs. This has included adaptation of project methods for the evaluation of the Affordable Medicines Facility-malaria (AMFm) pilot.3 The project implements a set of research tools designed to: 1) Provide a picture of the total market for malaria case management including: all providers carrying antimalarials and RDTs and providing case management services; the relative antimalarial market share for each provider type; the antimalarial supply chain; and price markups within the supply chain for antimalarials and RDTs. 2) Monitor the readiness of market components for appropriate malaria case management, including: availability of antimalarials and malaria blood testing; consumer price of antimalarial treatment and malaria blood testing; and provider qualifications, training and knowledge. 3) Monitor the performance of market components for appropriate malaria case management, including: the relative market share for quality-assured ACT relative to other antimalarial medicines; the demand for appropriate malaria case management captured through consumer knowledge, attitudes, and fever treatment seeking behavior; and the quality of provider service delivery measured against national policies, guidelines and minimum standards. ACTwatch research tools for malaria market monitoring include: 1. Outlet surveys Outlet surveys entail collecting quantitative data from all outlets and providers with the potential to sell or distribute antimalarials and/or provide malaria blood testing. These include health facilities, community health workers, pharmacies, Unregistered Pharmacies, retail outlets, market stalls, and mobile providers. A screening process identifies outlets that provide antimalarials and/or malaria blood testing. Among these eligible outlets, service providers are interviewed and all antimalarials and RDTs are audited. The audit collects information about each antimalarial and RDT in stock (e.g. brand name, drug active ingredients and strengths, manufacturer, etc.) and retailer reports on consumer price and sale/distribution volumes for each product. A representative sample of outlets is identified within target study domains such that findings from the outlet survey provide estimates of antimalarial and RDT availability, price, and relative market share across the entire market as well as within key market segments.4 2 Shewchuk T, O’Connell KA, Goodman C, Hanson K, Chapman S, Chavasse D. 2011. The ACTwatch project: methods to describe anti-malarial markets in seven countries. Malaria Journal, 10: 325. 3 AMFm Independent Evaluation Team. 2012. Independent evaluation of Phase 1 of the Affordable Medicines Facility – malaria (AMFm), multicountry independent evaluation report: final report. Calverton, MD and London: ICF International and London School of Hygiene and Tropical Medicine. 4 O’Connell KA, Poyer S, Solomon T, et al. 2013. Methods for implementing a medicine outlet survey: lessons from the anti-malarial market. Malaria Journal, 12: 52. www.ACTwatch.info Page 100 From 2008 through 2014, ACTwatch conducted 35 national outlet surveys across the 10 project countries.5 Reports are available at www.actwatch.info, and peer-reviewed publications have appeared in Malaria Journal and The Lancet.6 2. Supply chain studies Supply chain studies employ quantitative and qualitative research methods to effectively map the antimalarial supply chain in a given country. The supply chain is mapped from the antimalarial outlets (service delivery points) identified during an outlet survey to national importers and distributors with identification of all mid-level distributers in between. Retail prices are documented along the supply chain to facilitate calculation of commodity mark-ups. From 2008 through 2012, ACTwatch conducted 8 national supply chain studies. Reports are available at www.actwatch.info, and a peer-reviewed publication has appeared in PLoS One.7 3. Population-based surveys Population-based surveys are conducted among consumers to document fever treatment-seeking behavior. A representative sample of the target population (caregivers of children and/or adults according to burden and risk) is identified, and a screening tool is used to identify individuals who have recently experienced fever. The surveys investigate the extent to which health care was sought, as well as common sources of care received. Respondent reports of malaria blood testing and antimalarials acquired are documented and summarized. The survey includes measures of demographic and other individual, household/family, and community characteristics that can be used to develop consumer profiles as well as monitor equity in access to malaria case management. From 2008 through 2012, ACTwatch conducted 14 household surveys focused on fever treatment-seeking behavior. Reports are available at www.actwatch.info, and a peer-reviewed publication has appeared in Malaria Journal.8 4. Fever case management quality of care Fever case management quality of care is monitored using a set of research tools designed to measure aspects of the interaction between providers and clients. In 2015-2016, ACTwatch will launch fever case management quality of care studies in a subset of project countries. The tool or set of tools that is most appropriate and feasible in a given context is employed. These include: Exit interviews conducted with target consumers immediately after receiving fever case management services from target providers. A structured interview documents client reports about key aspects of service delivery including malaria blood testing, test results, medicines recommended/prescribed and obtained, counseling, and costs of services and commodities received. Exit interviews are also used to measure client recall and comprehension of provider counseling including instructions for completing prescribed drug regimens, as well as client satisfaction with services provided. Exit interviews may include measures of demographic characteristics to monitor equity in access to services and commodities. Structured observation documents aspects of the provider-client interaction using a checklist. A trained observer completes the checklist designed to document provider compliance with standard practice and procedures as well as aspects of client demand for specific products or services. The observer remains silent during the consultation. 5 Surveys in the DRC (2) and Myanmar (3) were sub-national. O’Connell K, Gatakaa H, Poyer S, et al. 2011. Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries. Malaria Journal, 10: 326. Tougher S, the ACTwatch Group, Ye Y, et al. 2013. Effect of the Affordable Medicines Facility-malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data. Lancet, 380: 1916-26. 7 Palafox B, Patouillard E, Tougher S, et al. 2014. Understanding private sector antimalarial distribution chains: a cross-sectional mixed methods study in six malaria-endemic countries. PLoS One, 9(4). 8 Littrell M, Gatakaa H, Evance I, et al. (2011). Monitoring fever treatment behavior and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries. Malaria Journal, 10: 327. 6 www.ACTwatch.info Page 101 ACTwatch in Kenya PSI conducted two rounds of outlet surveys in 2010 and 2011 in Kenya as part of the Independent Evaluation of the AMFm through support from the Global Fund. A follow-up outlet survey was conducted in 2014. www.ACTwatch.info Page 102 Annex 2: Kenya Background The Republic of Kenya is a country in East Africa and is bordered by Ethiopia, Sudan, Uganda, Tanzania and Somalia. It covers an area of 582,646 square kilometers, of which about 80% of the land area is arid and semi‐arid and only 20% is arable.9 It is divided into eight provinces, which are further subdivided into districts, divisions, locations, and sub‐ locations. According to the 2009 census, the population of Kenya was 38.6 million,10 and more recent World Bank figures estimate the population reached 44.86 million in 2014.11 In 2009, 42.9% of the population was aged below 15 years, and 67.7% lived in rural areas.12 Kenya is a lower middle-income country with a gross domestic product per capita of US $ 1,358.3 per capita in 2014, and an economy that is predominantly agrarian.13 The human development index is 0.535, ranking the country 147th out of 187 countries. Kenya experiences strong regional disparities in poverty as well as high rates of inequality of income distribution, particularly in urban areas. Health care system Kenya’s health care system consists of a network of more than 6,700 health facilities countrywide, with the public sector accounting for half of facilities.14 There has been a general increase in the number of healthcare personnel over the years and there was an average of 20.7 doctors and 159.3 nurses for every 100,000 persons by 2013.15 The public sector accounts for 60% of total health personnel, of whom about 70% are concentrated in hospitals.16 Kenya has two line of ministries responsible for health care delivery – the Ministry of Medical Services (MOMS) and the Ministry of Public Health and Sanitation (MOPHS) that together have the mandate to implement the National Health Sector Strategic Plan. Health services delivery is now organized with a focus on community delivery systems with community health units responsible for services at the community level. Community health units refer to primary care services provided at dispensaries and health centers at the sub-county level. Referral services are available at the county and national levels.17 The private for‐profit health sector is comprised of private hospitals, clinics, dispensaries and drug outlets and accounts for about one-third of health facilities in the country.18 Malaria risk and burden Approximately 75 percent of Kenya’s population resides in areas with malaria transmission (population of 33.7 million people), with 36 percent residing in areas of high transmission and 40% residing in areas of low transmission. In recent years, Kenya has experienced significant declines in malaria admissions and deaths at the national level. High malaria transmission is concentrated in the endemic areas around Lake Victoria.19 9 MOPHS. (2009). Towards a malaria-free Kenya: National Malaria strategy 2009-2017. Available: http://www.chubonline.org/sites/default/files/resources/main/Kenya_National_Malaria_Strategy_2009-2017.pdf. 10 KNBS. (2010). The 2009 Kenya Population and Housing Census: Volume 1c. Nairobi, Kenya: KNBS. 11 The World Bank (2015). Available: http://data.worldbank.org/indicator/SP.POP.TOTL/countries/KE?display=graph. 12 Kenya National Bureau of Statistics (KNBS). (2010). The 2009 Kenya population and Housing Census: Volume 1c. Nairobi, Kenya: KNBS. 13 The World Bank (2015). Available: http://data.worldbank.org/indicator/NY.GDP.PCAP.CD. 14 Division of Malaria Control [Ministry of Public Health and Sanitation]. (2010). National guidelines for the diagnosis, treatment and prevention of malaria in Kenya. Nairobi, Kenya: DOMC. 15 Ministry of Health. (2014). Kenya Health Policy 2014-2030: Towards attaining the highest standard of health. Nairobi, Kenya: Ministry of Health 16 Wamai R. G. (2009). The Kenya Health System – Analysis of the situation and enduring challenges. JMAJ 52(2): 134–140 17 Ministry of Health. (2014). Kenya Health Policy 2014-2030: Towards attaining the highest standard of health. Nairobi, Kenya: Ministry of Health 18 DOMC [MOPHS]. (2010). National guidelines for the diagnosis, treatment and prevention of malaria in Kenya. Nairobi, Kenya: DOMC 19 WHO. (2014). World Malaria Report 2014. WHO: Geneva. www.ACTwatch.info Page 103 Figure X1: Map of confirmed cases per 1000 population / parasite prevalence Source: Noor et al. (2009). The risks of malaria infection in Kenya in 2009, p. 9. Kenya has four malaria epidemiological zones that are largely defined by altitude, rainfall patterns and temperature. These areas include: 1. Endemic areas around Lake Victoria in Western Kenya and in the Coastal regions. Transmission in these areas is intense throughout the year, but peaks from June to August and again in late November following the rainy seasons. 2. Seasonal transmission areas. These are arid and semi‐arid areas of the northern and south-eastern parts of the country, which experience short periods of intense transmission during the rainy season. 3. Epidemic prone areas of Western highlands of Kenya. Malaria transmission here is seasonal with considerable year‐ to‐year variation. Case fatality rates during an epidemic can be up to ten times greater than those experienced in regions where malaria occurs regularly. 4. Low risk malaria areas. This zone covers the central highlands of Kenya including Nairobi, where temperatures are too low to allow completion of the sporogenic cycle of the malaria parasite in the vector. Malaria case management guidelines Diagnosis The national guidelines for malaria case management were updated in 2010 to recommend universal parasitological testing of all febrile patients in all areas of the country (regardless of endemicity) with malaria microscopy or RDTs. However, the guidelines noted that where confirmatory testing is not available, suspected malaria cases should not be denied antimalarial treatment.20 The first nationwide distribution of RDTs took place in 2012, following initial sub- 20 MOPHS (2010) National Guidelines for Diagnosis, Treatment and Prevention of Malaria for Health Workers. Third Edition. Ministry of Public Health and Sanitation & Ministry of Medical Services, Division of Malaria Control, Nairobi. www.ACTwatch.info Page 104 national pilot projects implemented since 2006.21 A major RDT stockout occurred in 2013 after a central warehouse fire in January destroyed over 4.2 million RDTs. A PMI procurement of 4.5 million RDTs arrived in March 2014 and RDTs were rolled out to community, dispensary and health centers.22 Access to diagnostic testing services is being expanded through the provision of RDTs to facilities that do not have microscopy. It is expected that with increased access to RDTs, provided through a Global Fund Round 10 Grant, rational use of ACTs will improve – thereby increasing access by decreasing demand.23 Treatment In 2004, Kenya changed its first-line treatment policy for uncomplicated malaria from SP to artemether lumefantrine (AL) 20/120.24 In 2010, the treatment policy was revised to recommend dihydroartemisinin piperaquine (DHA PPQ) for the second-line treatment and the use of AL during the second and third trimesters of pregnancy.25 Results of nationally representative biannual surveys to monitor outpatient malaria case management by the DOMC between 2010 and 2013 showed that availability of at least one AL pack was relatively high (range: 89.1%–97.2%), however, facilities less commonly had all four packs in stock (range: 45.4–71.5%).26 Financing and major initiatives to improve case management In the Kenya Malaria Strategy 2009-2017, the malaria case management objective is to have 100 percent of all suspected malaria cases presenting to a health provider managed according to the national malaria treatment guidelines by 2017. Strategies to achieve this objective include: 27 1) Capacity building of health workers in malaria diagnosis and treatment at health facilities 2) Access to affordable malaria medicines and diagnostics through the private sector 3) Strengthening community case management of malaria using the community strategy through community health workers 4) Ensuring commodity security of antimalarials and diagnostics in the public sector Kenya has implemented strategies to increase access to malaria blood testing and appropriate treatment with funding through the Affordable Medicines Facility, malaria (AMFm) and Global Fund Round 10 as well as support from DFID and the US President’s Malaria Initiative (PMI). The AMFm provided first-line buyers in the public and private sector with access to highly subsidized (co-paid) quality-assured ACTs. Medicines subsidized through the AMFm are marked with a ‘green leaf’ logo on the packaging. Phase 1 of the AMFm was implemented from 2010-2012. Kenya signed the AMFm grant in July 2010. Copaid ACTs arrived in-country for the private sector by August of 2010 and for the public sector by June of 2011. By the end of 2011, the number of copaid QA ACT treatments delivered to Kenya was approximately 14.35 million in the public sector and 14.1 million in the private sector. The independent evaluation of the AMFm in Kenya showed a successful increase in availability and market share for quality-assured ACTs. The median price for QA ACTs in the private sector fell dramatically between baseline and endline and the price was equal to that 21 Zurovac D, Githinji S, Memusi D, et al. (2014). Major improvements in the quality of malaria case-management under the “test and treat” policy in Kenya. PLoS One, 9(3): e92782. 22 PMI. (2015). Malaria Operational Plan 2015. Available: http://www.pmi.gov/docs/default-source/default-document-library/malaria-operational-plans/fy15/fy-2015-kenya-malaria-operational-plan.pdf?sfvrsn=3. 23 Key informant interviews conducted in December 2014. 24 Amin AA, Zurovac D, Kangwana BB, Greenfeld J, Otieno DN, et al. (2007) The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya. Malar J 6: 72. 25 MOPHS. (2010). National Guidelines for Diagnosis, Treatment and Prevention of Malaria for Health Workers. Third Edition. Ministry of Public Health and Sanitation & Ministry of Medical Services, Division of Malaria Control, Nairobi. 26 Zurovac D, Githinji S, Memusi D, et al. (2014). Major improvements in the quality of malaria case-management under the “test and treat” policy in Kenya. PLoS One, 9(3): e92782. 27 MOPHS. (2009). Towards a malaria-free Kenya: National Malaria strategy 2009-2017. Available: http://www.chubonline.org/sites/default/files/resources/main/Kenya_National_Malaria_Strategy_2009-2017.pdf. www.ACTwatch.info Page 105 of the most popular non-artemisinin therapy, SP.28 Transitional funding was provided by DFID in Kenya for co-paid ACTs through 2014. Kenya switched from a combined “push-pull” procurement system to a “pull” system based on AL consumption in 2012. This shift has been supported with activities to strengthen logistics and management information systems as well as various approaches to mitigate stock-outs as peripheral levels.29 Kenya has not experienced a stockout of AL at the central level for more than three years, which is an improvement over previous years when nationwide stockouts occurred regularly.30 28 AMFm Independent Evaluation Team. (2012). Independent evaluation of Phase 1 of the Affordable Medicines Facility – malaria (AMFm), multi-country independent evaluation report: Final report. Calverton MD and London: ICF International and London School of Tropical Medicine and Hygiene. 29 Zurovac D, Githinji S, Memusi D, et al. (2014). Major improvements in the quality of malaria case-management under the “test and treat” policy in Kenya. PLoS One, 9(3): e92782. 30 PMI. (2015). Malaria Operational Plan 2015. Available: http://www.pmi.gov/docs/default-source/default-document-library/malaria-operational-plans/fy15/fy-2015-kenya-malaria-operational-plan.pdf?sfvrsn=3. www.ACTwatch.info Page 106 Annex 3: Outlet Survey Methods Design and Study Population ACTwatch implements repeat cross-sectional outlet surveys in project countries. The study population is defined as all outlets with the potential to sell or distribute antimalarial medicines and/or provide malaria blood testing. In Kenya, this includes the following outlet types: Public health facilities National referral hospital, provincial general hospitals, health centers or sub-health centers and dispensaries. There are over 3,000 MOH public health facilities in Kenya. Private not for-profit health facilities Hospitals, clinics, and dispensaries operated by NGO, CBO, or faith-based organizations. There are over 1,100 private not for-profit facilities in Kenya. Community health workers Private for-profit health facilities Community-based health workers Registered pharmacies/chemists Pharmacies/Chemists are licensed and regulated by the Registered Pharmacy and Poisons Board and include Pharmacist Premises. By 2013, there were over 4,100 registered Pharmacies/Chemists in Kenya. Small businesses that are not registered with the Registered Pharmacy and Poisons Board, but sell various classes of prescription and over-the-counter medicine at commercial prices. Unregistered pharmacies Private hospitals, clinics, dispensaries, and diagnostic laboratories. There are over 3,100 private for-profit health facilities in Kenya. General retailers Supermarkets, duka, kiosks, market stalls, and petrol stations. Itinerant drug vendors Mobile providers typically working within a radius of their home. They are not registered with any national regulatory authority. Stratification The Kenya 2014 outlet survey is stratified to provide estimates for urban and rural domains. Urban and rural designations for all sub-counties in the sampling frame were obtained from the 1999 National Census classification of enumeration areas. Locations with 65% or greater population living in areas classified as urban or peri-urban were classified as urban. All other locations were classified s rural. Eligibility Criteria All outlets with the potential to sell or distribute antimalarials were included in the census screening. Outlets were eligible for a provider interview and malaria product audit if they met at least one of three study criteria: 1) one or more antimalarials reportedly in stock the day of the survey; 2) one or more antimalarials reportedly in stock within the three months preceding the survey; and/or 3) provides malaria blood testing (microscopy or RDT). Outlets that do not serve the general public (e.g. military facilities) were excluded from the study. Sample Size The outlet survey was powered to detect a 20 percentage point increase between 2011 and 2014 within each research domain (and nationally) in the indicator, the proportion of outlets that have quality-assured ACT in stock among all outlets with antimalarials in stock at the time of the survey. The required sample size for each research domain (urban www.ACTwatch.info Page 107 and rural strata) was calculated in three steps: 1) determine the required number of antimalarial-stocking outlets; 2) determine the number of outlets to be enumerated to arrive at this number of antimalarial-stocking outlets; and 3) determine the number of clusters for the census to arrive at this number of outlets. Required number of antimalarial-stocking outlets The number of antimalarial-stocking outlets required to detect a change over time in availability of ACT between survey rounds is given by: n = deff éë Za 2P(1- P) + Z1-b P1 (1- P1 ) + P2 (1- P2 ) ùû 2 (P2 - P1 )2 where: n= P1= P2= desired sample size the proportion of antimalarial-stocking outlets with quality assured ACT in stock in 2011 the expected proportion of antimalarial-stocking outlets with quality-assured ACT in stock in 2014 P= Zα/2= Z1-β= (P1+P2)/2 The standard normal deviate value for a α type I error (two-sided) The standard normal deviate value for a β type type II error Deff= design effect anticipated due to the cluster survey design. Design effects observed during the 2011 study were used for sample size calculations. The required size for the 2014 survey was calculated based on the following values of P1 and deff, estimated from the 2011 AMFm Independent Evaluation outlet survey: P1 deff Urban Domain 0.719 6.5 Rural Domain 0.634 6.4 In addition, the following values for key parameters were used: Zα/2 = 1.96, corresponding to an α (type I) error of 5% with a two-sided test Z1-β = 0.84, corresponding to a test power of 80% (or a type II error of 20%) The required numbers of antimalarial stocking outlets, calculated using the above formula, are 594 outlets in the urban domain and 617 outlets in the rural domain. The same formula was used to calculate the number of public health facilities and pharmacies required to detect change over time within each of these outlet types, in urban and rural areas. In 2011, QA ACT availability within these outlet types was observed as follows: urban public health facility: 0.920; rural public health facility: 0.974; urban Registered Pharmacy: 0.933. With a design effect of 2.0 in all cases, 114 urban and 84 rural public health facilities are required, and 107 urban pharmacies and 127 rural pharmacies are required. www.ACTwatch.info Page 108 Required number of antimalarial-stocking outlets The following formula was used to calculate the required number of enumerated outlets: N = n / Pam where: N= the required number of outlets enumerated n= the number of antimalarial stocking outlets Pam= the proportion of outlets having any antimalarial in stock at the time of the survey among all outlets enumerated The table below presents the estimates for Pam from the 2010 outlet survey and the required gross sample sizes calculated using the above formula. Urban Domain Rural Domain n 594 617 Pam 0.15 0.18 N 3,960 3,427 Thus a total of 3,960 outlets in the urban domain and 3,428 outlets in the rural domain must be interviewed in order to detect a 20 percentage point change in QA ACT availability between the 2014 and 2016 outlet surveys. During the 2011 national outlet survey, 90% of urban outlets and 79% of rural outlets enumerated were successfully screened, with reasons for non-participation including outlet temporary or permanent closure, non-availability due to busy providers, and refusal. Taking these non-participation rates into account, the total number of outlets required for enumeration is: 4,362 urban and 4,343 rural. Required number of clusters (location) The primary sampling approach entails sampling a set of administrative units (geographic clusters) with a corresponding population of approximately 10,000 to 15,000 inhabitants. The appropriate administrative unit in Kenya corresponding to this desired population size is location. The desired number of clusters (wards) is selected with probability of cluster selection proportionate to size (PPS). A census of all outlets with the potential to sell or distribute antimalarials will be conducted in sampled wards. The average number of outlets screened per cluster from the 2011 outlet survey was used to estimate the number of clusters required in 2014 to achieve the desired sample size. The following formula was used to calculate the required number of clusters: 𝐶 = 𝑁/𝑂̅ where: C= the required number of clusters N= the number of enumerated outlets ̅= O the mean number of outlets per cluster ̅ from the 2010/11 outlet survey and the required number of clusters The table below presents the estimates for O required using the above formula. Urban Domain Rural Domain N 4,362 4,343 ̅ 320.1 160.9 O C 14 27 The 2011 survey findings suggest that on average, each urban location will have 2.3 public health facilities and 2.5 pharmacies. In order to achieve a sufficiently large sample size of urban public health facilities and pharmacies using the census Location plus Division booster strategy, the optimal number of urban Locations was calculated at 26. www.ACTwatch.info Page 109 Thus a total of 26 urban and 27 rural clusters will be censused in order to detect a 20 percentage point change in QA ACT availability between the 2014 and 2016 outlet surveys, and to achieve sufficient sample sizes for public health facilities and pharmacies to allow for estimates within these key outlet types. Applying the above parameters to the stated formula yields the following required sample sizes: urban: 268; rural 813; total: 1,081. Sampling The primary sampling approach taken for outlet surveys entails sampling a set of administrative units (geographic clusters) with a corresponding population of approximately 10,000 to 15,000 inhabitants. The appropriate administrative unit in Kenya corresponding to this desired population size is Location. A representative sample of Locations was selected and a census of all outlets with the potential to sell or distribute antimalarials was conducted in sampled Locations. A ‘booster’ sample was used to increase the sample size for certain outlet types. The booster sample was drawn from the Divisions in which sampled Locations were located. Within booster sample Divisions, a census of the following outlet types was conducted: public health facilities and registered pharmacies. The sampling frame was generated using information from the 1999 National Census. Locations were defined as urban or rural according to information in the sampling frame provided at enumeration area (EA) level. The National Census classified EAs as urban, peri-urban, or rural. At the Location level, Locations with 65% or greater population living in areas classified as urban or peri-urban were classified as urban. All other locations were classified as rural. Clusters with recent documented security risks were excluded from sampling framework and these included all clusters in former North-Eastern Province and as well as clusters in former Coast Provinces (Tana River and Lamu). A representative sample of Locations was selected in each research domain (urban and rural areas) using one-stage cluster sampling. Two lists were prepared: a list of all urban Locations and a list of all rural Locations. The lists were sorted alphabetically by Province, District, Division, and Location and 26 urban and 27 rural Locations were sampled with probability proportional to population size (PPS). Selected/sampled locations with high population size of >40,000 persons were segmented into smaller units (sub-locations) and one sub-location was selected for the survey. The list of selected Locations is included in Annex 4. In these sampled locations, a census was conducted among all outlets with potential to stock antimalarials or/and provide malaria blood testing. In addition to the census of selected Locations, a booster sample was employed for pharmacies and public health facilities to reach the desired sample size for these key market segments. The booster strategy for public health facilities and pharmacies was to census all facilities and pharmacies within the Division of the sampled Location (i.e. expand the geographic scope for the census). Data Collection Interviewers, supervisors, and quality controllers received training that included an orientation to the study, questionnaire and use of PDAs, classroom training on completing antimalarial and RDT audits, and a field exercise. Following training, data collection was implemented from November 7 to December 22, 2014. For all interviews, a structured questionnaire was administered using paper questionnaires (see Annex 6). A series of screening questions were administered at all outlets to determine eligibility for the survey. Outlets where antimalarial medicines were reportedly sold and/or malaria blood testing was reportedly provided were invited to participate in the survey. Following informed consent procedures, an audit of all available antimalarial medicines and RDTs was conducted. Antimalarial audit information included formulation, package size, brand name, active ingredients and strengths, manufacturer, country of manufacture, reported sale/distribution in the week preceding the survey, retail price, and wholesale price. RDT audit information included brand name, manufacturer, country of manufacture, reported sale/distribution in the week preceding the survey, retail price, and wholesale price. Detailed descriptions of antimalarials and RDTs audited are provided in Annex 7 and Annex 8. In addition to the product audit, a series of questions was administered to the senior-most provider regarding malaria case management knowledge and practices as well as provider training and qualifications. Geo-coordinates were recorded for each outlet using a handheld Global Positioning System (GPS) unit. www.ACTwatch.info Page 110 Up to three visits were made to all outlets to complete the screening process, audit, and provider interviews as needed (e.g. where outlets were closed or providers were not available). Data Entry, Processing, and Analysis Data was collected using paper questionnaires and entered using Microsoft Access. All data cleaning and analysis was completed using Stata 13.1 (©StataCorp, College Station, TX). Sampling weights were applied to account for variations in probability of selection (see Annex 9) and standard error estimation accounted for clustering at the location and division levels. Indicator definitions are provided in Annex 10. Protection of Human Subjects Ethical approval was obtained from the Kenyatta National Hospital Ethics and Research Committee (KNH ERC) prior to conducting the study. The PSI Research Ethics Board ceded review to the committee in Kenya. Provider interviews and product audits were completed only after administration of a standard informed consent form and provider consent to participate in the study. Providers had the option to end the interview at any point during the study. Standard measures were employed to maintain provider confidentiality and anonymity. www.ACTwatch.info Page 111 Annex 4: Sampled Locations Table X1. Sampled locations Province District Division Location Urban/Rural Population CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST COAST KIAMBU KIAMBU KIAMBU KIAMBU KIAMBU KIAMBU KIAMBU KIAMBU KIAMBU KIRINYAGA KIRINYAGA KIRINYAGA KIRINYAGA MURANG'A MURANG'A MURANG'A MURANG'A NYERI NYERI NYERI NYERI NYERI THIKA THIKA THIKA THIKA THIKA THIKA THIKA THIKA THIKA KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE KWALE MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA KIKUYU KIKUYU KIKUYU KIKUYU KIKUYU KIKUYU KIKUYU KIKUYU KIKUYU CENTRAL CENTRAL CENTRAL CENTRAL KAHURO KAHURO KAHURO KAHURO KIENI EAST KIENI EAST KIENI EAST KIENI EAST KIENI EAST KAKUZI KAKUZI KAKUZI KAKUZI MUNICIPALITY MUNICIPALITY MUNICIPALITY MUNICIPALITY MUNICIPALITY KUBO KUBO KUBO KUBO KUBO KUBO MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI MSAMBWENI CHANGAMWE CHANGAMWE CHANGAMWE CHANGAMWE CHANGAMWE KISAUNI KISAUNI KINOO - Uthiru Sub-Loc KINOO - Gitiba Sub-Loc KINOO - Kinoo Sub-Loc KINOO - Thogoto Sub-Loc KABETE KARAI KIKUYU MUGUGA NYATHUNA KUTUS INOI KERUGOYA KOROMA MUGOIRI KAHUHIA MURARANDIA WEITHAGA GAKAWA KABARU KIAMATHAGE NAROMORU THIGU MITUMBIRI ITHANGA KAKUZI SAMURU THIKA MUNICIPAL- Komu Sub-Loc THIKA MUNICIPAL - Biashara Sub-Loc THIKA MUNICIPAL - Karimeni Sub-Loc THIKA MUNICIPAL - Majengo Sub-Loc GATUANYAGA MWALUPHAMBA LUKORE MAJIMBONI MANGAWANI MKONGANI MWALUVANGA DIANI - Gombato Sub-Loc DIANI - Bongwe Sub-Loc DIANI - Ukunda Sub-Loc DZOMBO KIKONENI KINGWEDE/SHIRAZ KINONDO LUNGA MIVUMONI MSAMBWENI MWERENI PONGWE/KIDIMU VANGA PORT REITZ CHANGAMWE KIPEVU MIKINDANI MIRITINI KISAUNI - Kisauni Sub-Loc KISAUNI - Junda Sub-Loc urban urban urban urban urban rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural urban urban urban urban rural rural rural rural rural rural rural urban urban urban rural rural rural rural rural rural urban rural rural rural urban urban urban urban urban urban urban www.ACTwatch.info 15,145 3,766 14,474 11,726 30,899 27,951 33,907 33,103 23,994 12,258 25,826 22,717 12,834 31,413 14,818 29,995 16,493 22,797 19,203 10,678 17,667 10,522 19,304 18,199 26,026 8,389 54,120 10,607 4,648 17,593 17,875 16,648 2,619 6,170 7,444 13,070 2,892 18,045 7,962 23,936 30,226 14,691 8,912 18,121 16,848 8,639 14,381 26,736 12,372 11,473 53,401 11,314 44,583 32,267 29,953 51,508 13,454 Page 112 COAST COAST COAST COAST COAST COAST COAST COAST EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN EASTERN NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA MOMBASA EMBU EMBU EMBU EMBU ISIOLO ISIOLO ISIOLO ISIOLO MACHAKOS MACHAKOS MACHAKOS MACHAKOS MACHAKOS MAKUENI MAKUENI MAKUENI MAKUENI MAKUENI MAKUENI MBEERE MBEERE MBEERE MBEERE MERU CENTRAL MERU CENTRAL MERU CENTRAL MERU CENTRAL MERU CENTRAL MERU CENTRAL MERU NORTH MERU NORTH NITHI (MERU S.) NITHI (MERU S.) NITHI (MERU S.) NITHI (MERU S.) NITHI (MERU S.) NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI KISAUNI KISAUNI KISAUNI LIKONI LIKONI LIKONI LIKONI LIKONI MANYATTA MANYATTA MANYATTA MANYATTA CENTRAL CENTRAL CENTRAL CENTRAL KANGUNDO KANGUNDO KANGUNDO KANGUNDO KANGUNDO KATHONZWENI KATHONZWENI KATHONZWENI KATHONZWENI KATHONZWENI KATHONZWENI GACHOKA GACHOKA GACHOKA GACHOKA MIRIGA MIERU E. MIRIGA MIERU E. MIRIGA MIERU E. MIRIGA MIERU E. MIRIGA MIERU E. MIRIGA MIERU E. MUTUATI MUTUATI MWIMBI MWIMBI MWIMBI MWIMBI MWIMBI CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL CENTRAL DAGORETTI DAGORETTI DAGORETTI DAGORETTI DAGORETTI DAGORETTI EMBAKASI EMBAKASI EMBAKASI EMBAKASI EMBAKASI EMBAKASI KISAUNI - Magogoni Sub-Loc BAMBURI KONGOWEA LIKONI - Likoni Sub-Loc LIKONI - Bofu Sub-Loc LIKONI - Timbwani Sub-Loc MTONGWE SHIKA ADABU NGANDORI GATURI NORTH NGINDA RUGURU ISIOLO EAST CENTRAL ISIOLO WEST NGARE MARA KANZALU KAKUYUNI KANGUNDO KAWETHEI KIVAANI KITISE KANTHUNI KATHONZWENI KITHUKI MAVINDINI MBUVO MAVURIA KIAMBERE KIANJIRU MBETI SOUTH THUURA CHUGU GIAKI KIBURINE MULATHANKARI MUNITHU KABACHI NAATHU GANGA CHOGORIA KIERA MAARA MURUGI MATHARE - Mathare Sub-Loc MATHARE - Mabatini Sub-Loc MATHARE - Mlango Kubwa Sub-Loc HURUMA KARIOKOR NGARA STAREHE MUTUINI KAWANGWARE KENYATTA/GOLF C RIRUTA UTHIRU/RUTHMITU WAITHAKA EMBAKASI UMOJA - Savannah Sub-Loc UMOJA - Umoja Sub-Loc DANDORA KARIOBANGI S. KAYOLE urban urban urban urban urban urban urban urban rural rural rural rural urban urban rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural urban urban rural rural urban urban rural rural rural rural rural rural rural urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban www.ACTwatch.info 45,565 39,687 86,581 15,054 24,924 18,584 20,507 14,270 22,342 12,324 27,836 9,022 10,416 23,084 11,409 6,334 18,381 15,776 28,306 15,644 13,130 8,495 7,787 17,998 9,605 12,810 8,997 17,259 10,860 17,479 13,953 9,608 12,759 7,540 6,619 11,103 9,444 34,110 22,221 16,170 14,587 9,042 10,907 13,368 25,501 17,260 25,986 87,386 33,975 24,158 14,151 14,534 86,884 28,528 65,987 23,250 20,142 22,982 30,206 62,666 109,438 17,467 98,125 Page 113 NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI NAIROBI GUCHA(S. KISII) GUCHA(S. KISII) KISII CENTRAL KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU KISUMU N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA EMBAKASI EMBAKASI EMBAKASI KASARANI KASARANI KASARANI KASARANI KASARANI KASARANI KASARANI KASARANI KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA KIBERA PUMWANI PUMWANI PUMWANI PUMWANI PUMWANI WESTLANDS WESTLANDS WESTLANDS WESTLANDS WESTLANDS WESTLANDS WESTLANDS WESTLANDS OGEMBO OGEMBO TOWNSHIP KADIBO KADIBO KADIBO KADIBO WINAM WINAM WINAM WINAM WINAM WINAM WINAM WINAM WINAM WINAM WINAM WINAM EKERENYO EKERENYO EKERENYO EKERENYO EKERENYO EKERENYO EKERENYO EKERENYO NYAMIRA MUKURU KWA NJEN NJIRU RUAI KARIOBANGI - Kariobangi North Sub-Loc KARIOBANGI - Baba Dogo Sub-Loc GITHURAI KAHAWA KASARANI KOROGOCHO ROYSAMBU RUARAKA KIBERA - Makina Sub-Loc KIBERA - Kibera Sub-Loc KIBERA - Lindi Sub-Loc KIBERA - Silanga Sub-Loc SERA NGOMBE - Olympic Sub-Loc SERA NGOMBE - Gatwikira Sub-Loc KAREN LAINI SABA LANGATA MUGUMOINI NAIROBI WEST BAHATI EASTLEIGH NORTH EASTLEIGH SOUTH KAMUKUNJI PUMWANI HIGHRIDGE - Karura Sub-Loc HIGHRIDGE - Highridge Sub-Loc HIGHRIDGE - Muthaiga Sub-Loc KANGEMI KILIMANI KITISURU LAVINGTON PARKLANDS SENGERA M/CHACHE TOWNSHIP KOMBURA BWANDA KAWINO KOCHIENG' S.W. KISUMU CENTRAL KISUMU CENTRAL KOLWA EAST KAJULU EAST KISUMU EAST KOLWA KONDELE MIWANI NORTH KISUMU TOWNSHIP WEST KAJULU WEST KOLWA EKERENYO - Boisanga II Sub-Loc EKERENYO - Boisanga I Sub-Loc EKERENYO - Bokurati I Sub-Loc EKERENYO - Bokurati II Sub-Loc EKERENYO - Ikonge Sub-Loc BOMWAGAMO KIABONYORU N. MUG. CHACHE BONYAMATUTA CHA urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban urban rural rural urban rural rural rural rural urban urban urban urban urban urban urban rural urban urban urban urban rural rural rural rural rural rural rural rural urban www.ACTwatch.info 62,271 17,730 12,461 31,905 39,373 48,168 32,272 37,620 44,141 27,492 79,079 32,450 16,082 17,859 16,643 21,454 24,209 8,879 51,896 16,015 29,604 41,868 39,098 66,758 50,390 18,154 20,074 14,826 25,050 6,723 59,125 44,312 27,790 18,818 11,365 30,933 47,827 34,956 11,759 7,620 12,119 17,284 18,845 15,028 19,615 11,919 27,633 15,580 69,225 8,142 16,210 40,083 17,174 66,953 7,216 9,808 6,765 4,767 14,710 14,143 35,179 40,720 21,903 Page 114 NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA NYANZA R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA N.KISII(NYAMIRA RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO RACHUONYO BARINGO BARINGO BARINGO BARINGO BURET BURET BURET BURET BURET KAJIADO KAJIADO KAJIADO KAJIADO KAJIADO KAJIADO KAJIADO KAJIADO KAJIADO KERICHO KERICHO KERICHO KERICHO KERICHO KERICHO KERICHO KERICHO NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAKURU NAROK NAROK NAROK NAROK NAROK NYAMIRA NYAMIRA NYAMIRA NYAMIRA NYAMIRA NYAMIRA KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KASIPUL KOLLOWA KOLLOWA KOLLOWA KOLLOWA SOTIK SOTIK SOTIK SOTIK SOTIK NGONG NGONG NGONG NGONG NGONG NGONG NGONG NGONG NGONG KIPKELION KIPKELION KIPKELION KIPKELION KIPKELION KIPKELION KIPKELION KIPKELION BAHATI BAHATI BAHATI BAHATI NAKURU MUNI. NAKURU MUNI. NAKURU MUNI. NAKURU MUNI. NAKURU MUNI. NAKURU MUNI. RONGAI RONGAI RONGAI RONGAI RONGAI CENTRAL CENTRAL MULOT MULOT MULOT BOGICHORA BONYAMATUTA MAS BOSAMARO CHACHE BOSAMARO MASABA KEERA W. MUGIRANGO KONUONGA EAST KAMAGAK KACHIEN KAKELO KODERA KOJWACH KOKECH KOKWANYO KOWIDI NORTH KAMAGAK WEST KAMAGAK TIRIOKO KOLLOWA LOIWAT NGORON KAMUNGEI CHEMAGEL KAPLETUNDO KIMOLWET MANARET ONGATA RONGAI C. KEEKONYOKIE KISERIAN MOSIRO N. KEEKONYOIKE NGONG NKAIMORONYA OLOOLUA S. KEEKONYOKIE CHEPSEON BARSIELE KAMASIAN KAPSEGER KIMUGUL KIPCHORAN KIPSEGI LESIRWA DUNDORI BAHATI KABAZI SOLAI CENTRAL - Afraha Sub-Loc CENTRAL - Baharini Sub-Loc BARUTI KAPTEMBWO LAKE NAKURU LANET RONGAI BOROR KAMPI YA MOTO LENGINET MAKONGENI LOWER MELILI NKARETA SOGOO ENELERAI ILMOTIOK rural urban rural rural urban urban rural urban rural rural rural rural urban rural urban rural urban rural rural rural rural rural rural rural rural rural urban rural rural rural rural urban rural rural rural rural rural rural rural rural rural rural rural rural rural rural rural urban urban urban urban urban urban rural rural rural rural rural urban rural rural rural rural www.ACTwatch.info 16,789 15,963 16,937 15,739 19,120 27,168 8,268 12,991 7,583 14,658 13,018 15,941 7,929 8,659 12,165 13,313 15,626 2,249 5,199 3,049 4,484 14,717 22,860 8,661 7,433 6,491 23,849 9,216 16,441 3,200 12,007 15,767 36,242 17,734 12,680 10,832 4,253 10,702 9,206 9,494 6,873 8,360 4,420 35,384 53,746 26,815 28,359 27,706 51,491 9,331 109,956 763 36,648 15,367 10,687 18,353 16,959 15,529 29,599 11,295 17,943 8,832 10,960 Page 115 R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY R/VALLEY WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN WESTERN NAROK NAROK TRANS NZOIA TRANS NZOIA TRANS NZOIA UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU UASIN GISHU BUNGOMA BUNGOMA BUNGOMA BUNGOMA BUNGOMA BUNGOMA BUNGOMA BUNGOMA BUTERE/MUMIAS BUTERE/MUMIAS BUTERE/MUMIAS BUTERE/MUMIAS BUTERE/MUMIAS BUTERE/MUMIAS BUTERE/MUMIAS KAKAMEGA KAKAMEGA LUGARI LUGARI LUGARI LUGARI VIHIGA VIHIGA VIHIGA VIHIGA MULOT MULOT KWANZA KWANZA KWANZA KESSES KESSES KESSES KESSES KESSES KESSES KESSES KESSES KESSES KESSES SOY SOY SOY SOY SOY SOY SOY SOY SOY KIMILILI KIMILILI KIMILILI KIMILILI NDIVISI NDIVISI NDIVISI NDIVISI KHWISERO KHWISERO KHWISERO KHWISERO KHWISERO KHWISERO KHWISERO MUNICIPALITY MUNICIPALITY LIKUYANI LIKUYANI LIKUYANI LIKUYANI TIRIKI WEST TIRIKI WEST TIRIKI WEST TIRIKI WEST MULOT SAGAMIAN KAPOMBOI KAISAGAT KWANZA TARAKWA CHEPTIRET CHUIYAT KAPKOI KESSES KIPCHAMO MEGUN OL'LEINGUSE TIMBOROA TULWET SEGERO KIBULGENY KIPLOMBE KIPSOMBA KOISAGAT MOI'S BRIDGE SIRIKWA SOY ZIWA KIMILILI KAMUKUYWA KIBINGEI MAENI CHETAMBE LUKUSI NAMARAMBI NDIVISI WEST KISA CENTRAL KISA EAST KISA KISA SOUTH MULWANDA NORTH KISA SHIROMBE BUKHUNGU SHIEYWE LIKUYANI KONGONI NZOIA SINOKO GISAMBAI BANJA JEPKOYAI TAMBUA rural rural rural rural rural urban rural rural rural rural urban rural rural rural rural rural urban rural rural rural rural rural rural rural urban rural urban urban rural rural rural rural rural rural rural rural rural rural rural urban urban rural rural rural rural rural rural rural rural www.ACTwatch.info 17,330 12,853 31,051 22,452 34,862 13,863 6,196 5,381 4,034 13,311 6,159 8,364 12,754 10,009 4,645 10,082 39,925 18,002 15,747 15,686 36,018 5,457 14,617 7,883 26,886 24,241 26,825 17,598 17,723 13,803 14,969 11,546 9,747 16,584 10,009 9,359 19,546 14,081 8,742 36,511 35,048 19,824 33,530 22,269 15,922 19,884 21,871 17,515 17,070 Page 116 Annex 5: Detailed Sample Description Table X2: Detailed sample description Number of outlets screened (Figure 1 Box B) Urban Census Booster Rural Census Booster Number of outlets eligible and interviewed (Figure 1 Box D) Urban Census Booster Rural Census Booster Number of outlets eligible but not interviewed (interview nonparticipation) Urban Census Booster Rural Census Booster Number of interviewed outlets with at least one antimalarial in stock on the day of the survey (Figure 1, Box D1) Urban Census Booster Rural Census Booster Number of interviewed outlets with at least one antimalarial in stock on the day of the survey or at least one antimalarial Public Health Facility Community Health Workers Private Not ForProfit Facilities Private for-profit Health Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Outlets 485 182 60 122 303 68 235 477 175 57 118 302 67 235 553 293 293 0 260 260 0 58 14 14 0 44 44 0 58 34 34 0 24 24 0 50 29 29 0 21 21 0 453 351 351 0 102 102 0 407 314 314 0 93 93 0 503 454 179 275 49 23 26 492 444 175 269 48 22 26 572 469 469 0 103 103 0 557 458 458 0 99 99 0 9950 6342 6342 0 3608 3608 0 408 125 125 0 283 283 0 12676 8224 7827 397 4452 4191 261 2449 1559 1172 387 890 629 261 0 0 0 0 0 0 0 1 0 0 0 1 1 0 0 0 0 0 0 0 0 7 7 7 0 0 0 0 8 8 3 5 0 0 0 6 6 6 0 0 0 0 6 0 0 0 6 6 0 28 21 16 5 7 7 0 457 160 52 108 297 65 232 17 3 3 0 14 14 0 43 27 27 0 16 16 0 342 262 262 0 80 80 0 487 439 173 266 48 22 26 536 441 441 0 95 95 0 251 71 71 0 180 180 0 2133 1403 1029 374 730 472 258 471 52 50 375 492 557 408 2405 www.ACTwatch.info Page 117 Table X2: Detailed sample description Reportedly in stock in the previous 3 months (Figure 1 sum of Box 1 and Box 2) Urban Census Booster Rural Census Booster Number of interviewed outlets that provide malaria blood testing, but do not stock antimalarial medicines (Figure 1 Box D3) Urban Census Booster Rural Census Booster Proportion of eligible and interviewed antimalarial-stocking outlets with at least one provider with a health-related qualification* Urban Census Booster Rural Census Booster * Public Health Facility Community Health Workers Private Not ForProfit Facilities Private for-profit Health Facility Registered Pharmacy Unregistered Pharmacy General Retailer ALL Outlets 171 55 116 300 65 235 12 12 0 40 40 0 29 29 0 21 21 0 285 285 0 90 90 0 444 175 269 48 22 26 458 458 0 99 99 0 125 125 0 283 283 0 1524 1139 385 881 620 261 6 4 2 2 2 2 0 6 2 2 0 4 4 0 0 0 0 0 0 0 0 32 29 29 0 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 35 33 2 9 9 0 99.78 100.00 100.00 100.00 99.66 100.00 99.57 88.24 66.67 66.67 92.86 92.86 - 100.00 100.00 100.00 100.00 100.00 - 99.12 98.85 98.85 100.00 100.00 - 99.38 99.54 100.00 99.25 97.92 100.00 96.15 97.19 98.63 98.63 90.53 90.53 - 7.29 7.14 7.14 7.34 7.34 - 88.09 94.49 92.68 99.46 75.76 62.82 99.22 Health-related qualifications include: medical doctor, pharmacist, nurse, midwife, laboratory technician, registered pharmacy technician, community health assistant, and community health worker Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 118 Annex 6: Questionnaire ACTwatch Outlet Survey Section 1: Census Information KENYA 2014 Interviewer completes this section for all outlets. Outlet ID Interviewer-Dist- Div-Loc -Outlet ID C1. Today’s date (dd/mm/yyyy) [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] [___|___]-[___|___]-[_2_|_0_|_1_|_4_] C2. Interviewer’s name [_____________________________________________] C3. District [_____________________________________________________] C4. Division [__________________________________________________________________] C5. Location name [__________________________________________________________________] C6. Name of outlet If no name, record “no name” or owner’s name [__________________________________________________________________] C7. Type of Outlet 11 = NGO Hospital 01 = Public National Referral Hospital 02 = Public County Referral Hospital 03 = Public Sub-County Hospital 04 = Public Health Centre/ Sub-Health Centre 05 = Public Dispensary/ Clinic 06 = Community Health Worker 07 = Registered Pharmacy/Chemist 08 = Unregistered Registered Pharmacy/Chemist 09 = Private Hospital/Nursing Home 10 = Private Clinic/Dispensary C2a. Interviewer’s code [___|___] C3a. District code C4a. Division code [___|___] [___|___|___] C5a. Location code [___|___|___|___] C6a. Outlet code [___|___|___] 12 = NGO/CBO Clinic/Dispensary 13 = Mission/Faith-based Hospital 14 = Mission/Faith-based Clinic/Dispensary 15 = Supermarket/ Chain Store 16 = Duka/Kiosk/Market Stall/Petrol Station/Convenience Store 17 = Hawker 18 = Private Diagnostic Lab (Lab only) 19 = NGO/Mission Diagnostic Lab (Lab only) 96 = Other (specify) [____________________________________] C8. Is this area part of the booster sample? 1 = Yes 0 = No C8a. Is this outlet listed as part of PS/K private sector RDT project? (Refer to PS/K list) 1 = Yes [___|___] [___] 0 = No [___] Hello, my name is __________, I work for IPSOS on behalf of Population Services International. We are conducting a study on the availability of antimalarial medicines and diagnostic testing services. The results will be used to improve the availability of appropriate antimalarial treatment in Kenya. I would like to ask you a few questions to see if you could be part of the survey. Section 2: Screening & Eligibility S1. Do you have any medicines in stock today? 1 = Yes Go to S3 0 = No S2. Are there any medicines that are out of stock today, but that you stocked in the past 3 months? 1 = Yes Go to S4 0 = No Go to S5 8 = Don’t know Go to S5 S3. Do you have any antimalarial medicines in stock today? 1 = Yes Provide information sheet & gain consent. Record start time in C9. Proceed to Section 3: Antimalarial Audit. 0 = No Verify with prompt card. Go to S4 S4. Are there any antimalarial medicines that are out of stock today, but that you stocked in the past 3 months? 1 = Yes Provide information sheet & gain consent. Record start time in C9. Proceed to A16. 0 = No Verify with prompt card. Go to S5 8 = Don’t know Verify with prompt card. Go to S5 S5. Are you offering any diagnostic services or selling any diagnostic tests here today? 1 = Yes Go to S6 0 = No Verify with prompt card. Record details in C9 then complete Sec 7: ORS & Zinc then Sec X: Ending Interview www.ACTwatch.info [___] [___] [___] [___] [___] Page 119 S6. Are any of these services or tests for suspected malaria? 1 = Yes Provide information sheet & gain consent. Record start time in C9. Proceed to Section 4: Diagnostic Audit 0 = No Verify with prompt card. Record details in C9 then complete Sec 7: ORS & Zinc and Sec X: Ending Interview [___] Before proceeding to the full interview ensure you have given the respondent a study information sheet, explained the study and obtained informed consent. C9. Result of Visit(s) Date (dd/mm/yy) Time started (use 24hr clock) Time completed (use 24hr clock) Visit 1 Visit 2 Visit 3 [___|___]-[___|___]-[_1_|_4_] [___|___]-[___|___]-[_1_|_4_] [___|___]-[___|___]-[_1_|_4_] [___|___]:[___|___] [___|___]:[___|___] [___|___]:[___|___] [___|___]:[___|___] [___|___]:[___|___] [___|___]:[___|___] Result [___|___] [___|___] [___|___] 01 = Outlet eligible & survey completed go to E1 02 = Outlet ineligible: does not meet any screening criteria go to E1 03 = Interview interrupted go to C11 04 = Respondent not available/time not convenient go to C11 05 = Outlet not open at the time go to C11 06 = Outlet closed permanently go to E1 96 = Other (specify):[_____________________________________________________________] 97 = Refused go to C10 C10. If the provider refused, why? 1 = Client load Ask respondent for a time they would prefer to be interviewed and note in C11 2 = Thinks it’s an inspection / nervous about license go to E1 [___] 3 = Not interested go to E1 6 = Other (specify):[___________________________________________________________________] 7 = Refuses to give reason go to E1 C11. Use this space to record call back details. If it is not possible to complete the interview at another time, go to E1. Section 7: ORS & Zinc: Read to the provider: I have just a few questions for you about availability of treatments for diarrhea. ORS1. Do you have any oral rehydration salts, also known as ORS in stock today? Verify with prompt card. 1 = Yes 0 = No ORS2. Do you have any zinc tablets for treatment of diarrhea in children in stock today? Verify with prompt card. 1 = Yes 0 = No Go to C9 – Results of visit ORS3. Which strength of zinc tablets for treatment of diarrhea in children do you have in stock today? Read list, circle ALL that apply 10mg 20mg Other, specify :[______________________________] ORS4. Do you have any ORS that is packaged together with zinc treatment for diarrhea in children in stock today? Verify with prompt card 1 = Yes 0 = No www.ACTwatch.info [___] [___] A B C [___] Page 120 Section X: Ending the interview E1. Name of interviewee: 5 = Not applicable, no respondent; 7 = Refused E2. Physical address or location identifiers of outlet (not PO box) (Give detailed description that will help supervisor to find the outlet) [___] E3. Telephone number 9999999995 = Not applicable: no respondent or has no telephone 9999999997 = Refused [___|___|___|___|___|___|___|___|___|___] E4.Latitude: [__] -[___|___|___] .[___|___|___|___|___] E7. Additional observations by interviewer (if any) E5.Longitude: [_E_]-[___|___|___] .[___|___|___|___|___] THANK THE PROVIDER AND END INTERVIEW www.ACTwatch.info Page 121 Section 3: Antimalarial Audit A0. Read to the provider: Can you please show us the full range of antimalarials that you currently have in stock? Do you currently have any of the following? Prompt entire list using antimalarial prompt card; No response to be recorded. Artemether lumefantrine, such as Lonart, Artefan, Coartem Artemisinin combination therapies, such as Duo-Cotexcin, Co-arinate, P-Alaxin Artemisinin monotherapies, such as, Arinate, Artemedine Artemether such as, Gvither SP, such as Fansidar, Metakelfin, Ekelfin, Orodar Amodiaquine, such as, Malaratab, Loquin Quinine, such as, Quinitab, Quinimax, Falciquin Mefloquine, such as Mephaquin, Meflotas, Mequin Chloroquine, such as, Falcin, Maladrin Syrups or suspensions, such as, Falcidin, Amoquin Injectables, such as, Larither, Paluther, Quinine Granules or powders, such as Artequin, Paediatric If the outlet has no antimalarials in stock cross-check screening results then proceed to question A16. Proceed to the antimalarial audit. Different antimalarial audit sheets will be used to record the antimalarial information based on the dosage form of the medicine. Separate the antimalarials into two piles: The first pile should contain all the antimalarials in the form of tablets, suppositories, or granules. Use the Tablets, Suppositories & Granules Drug Audit Sheet to record these. The second pile should contain all the antimalarials in any form other than tablets, suppositories or granules. Use the Non-Tablet Drug Audit Sheet to record these. If additional audit sheets are used, add these sheets after the ones provided and staple the questionnaire again. All pages should be in order before you move onto the next outlet. Number each drug by assigning a Product Number (starting from 1 for TSG drugs and again from 1 for NT drugs). Number each audit sheet used in the spaces provided at the bottom of the page. ADDITIONAL NOTES ON THE SUB-OUTLET CODE In all outlets, complete the Sub-Outlet Code (as well as the Product Number) for each drug audited. These codes are listed below. SUB-OUTLET CODES X ALL outlets that have only ONE dispensing/distribution point for medicines/diagnostics A Outpatient department / dispensary/Main Registered Pharmacy (if used by all patients) B Adult outpatient department / adult dispensary / adult clinic C Child outpatient department / child dispensary / child clinic D Antenatal / maternity clinic/MCH E ART / HIV/AIDS clinic/Comprehensive Care Clinic (CCC) G Private dispensing unit within a public health facility L Laboratory (for RDT audit) Z Other (specify the type in the space for audit comments –TSG 15 or NT 15) www.ACTwatch.info Page 122 TABLET, SUPPOSITORY & GRANULE DRUG AUDIT SHEET (TSG)OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Sub-outlet code 1. Generic name [__|__] [_____] _______ Product number [__|__] [__|__] [__|__|__] 5. Manufacturer 12. Retail selling price 2. Strength [__|__|__].[__]mg [__] [__|__|__].[__]mg [__] [__|__|__].[__]mg 1 = Yes 0 = No 8 = Don’t know [__] If no, specify salt: 3. Dosage form/formulation 4. Brand name (Include weight and age information) 1 = Tablet 2 = Suppository 3 = Granule [___] [________________________] 7. Package size 8. Is product 9. Does 10. Amount sold/distributed in the last 7 days to individual a fixed-dose product consumers (Record # of packages / tins described in Q7 OR record There are a total of combination have the the total # of tablets / suppositories / granule packs sold) (FDC) AMFm [___|___|___|___] logo? This outlet sold [___|___|___] packages/ tins in the last 7 days tablets/ suppositories/ 1 = Yes granule sachets in 1 = Yes OR 0 = No each: 0 = No 8 = Don’t This outlet sold [___|___|___] tablets/ suppositories or granule 8 = Don’t know 1 = Package sachets in the last 7 days know 2 = Pot/tin Not applicable = 995; Refused = 997; Don’t know = 998 [___] [___] [__|__|__] [___] 13. Wholesale purchase price 14. Why do you stock this medicine [SHOW PRODUCT]? 15. Comments Do not read list. For the outlet’s most recent wholesale purchase Circle ALL responses given [__|__] 6. Country of manufacture [___|___|___] tablets, suppositories or granule sachets cost an individual customer [___|___|___|___] tablets, suppositories or granule sachets cost [___|___|___|___] KSH [___|___|___|___|___] KSH Free = 0000 Refused = 9997 Don’t know = 9998 2a. Is this base strength? Free = 00000 Refused = 99997 Don’t know = 99998 11. Stocked out at any point in the past 3 months? 1 = Yes 0 = No 8 = Don’t know [___] Free supply A Profitable B Recommended by the government C Low price D Customer demand or preference E Positive brand reputation F Often prescribed by doctors G Most effective for treating malaria H Don’t know X Other Z specify [_________________________________] Tablet Audit Sheet [__|__] of [__|__] www.ACTwatch.info Page 123 NON-TABLET DRUG AUDIT SHEET (NT): SYRUP, SUSPENSION, INJECTIONS & OTHERS Sub-outlet code 1. Generic name 2. Strength [__|__] [_____] _______ Product number 2a. Is this base strength? [__|__|__|__].[__]mg/[__|__|__] .[__]mL [__|__] [__|__|__|__].[__]mg/[__|__|__] .[__]mL [__|__] [__|__|__|__].[__]mg/[__|__|__] .[__]mL (Note: no mL recorded for powder injection) [__|__|__] 4. Brand name (Include weight and age information) OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] [__|__] 5. Manufacturer 6. Country of manufacture 7. Package size There are a total of [__] [__] [__] If no, specify salt: 12. Retail selling price [___|___|___] bottles ampoules or vials cost an individual customer 13. Wholesale purchase price For the outlet’s most recent wholesale purchase: [___|___|___|___] bottles, ampoules or vials cost [___|___|___|___] KSH [___|___|___|___|___] KSH Free = 0000 Refused = 9997 Don’t know = 9998 Free = 00000 Refused = 99997 Don’t know = 99998 1 = Syrup 2 = Suspension 3=Liquid injection 4 =Powder injection 5 = Drops 6 = Other (specify) [___________] [______________________] 9. Does this 10. Amount sold/ distributed in product have the last 7 days to individual the AMFm logo? consumers [___|___|___|___].[__] mL 1 = Yes (or mg for powder 0 = No injections) in each: 8 = Don’t 1 = Bottle know 2 = Ampoule/vial [__|__|__] 1 = Yes 0 = No 8 = Don’t know 3. Dosage form/formulation This outlet sold [___|___|___|___] bottles, ampoules or vials in the last 7 days [___] 11. Stocked out at any point in the past 3 months? 1 = Yes 0 = No 8 = Don’t know [___] Refused = 9997; Don’t know = 9998 14. Why do you stock this medicine [SHOW PRODUCT]? 15. Comments Do not read list. Circle ALL responses given [___] [___] Free supply A Profitable B Recommended by the government C Low price D Customer demand or preference E Positive brand reputation F Often prescribed by doctors G Most effective for treating malaria H Don’t know X Other Z specify [_________________________________] Non-Tablet Audit Sheet [___|___] of [___|___] www.ACTwatch.info Page 124 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Antimalarials recently in stock A16. Are there any antimalarial medicines that are out of stock today, but that you stocked in the past 3 months? 1 = Yes 0 = No 8 = Don’t know go to A17 go to Section 4: Diagnostic Audit go to Section 4: Diagnostic Audit [___] A17. What are the names of the treatments that are out of stock? Will accept generic or brand names. Record one medicine per line. 1 = Yes, specify [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [_______________________________________] [___] 0 = No, provider can’t remember Interviewer: Go to Section 4: Diagnostic Audit www.ACTwatch.info Page 125 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Section 4: Diagnostic Audit This section is about availability of malaria blood testing. Completing the questions may require speaking with more than 1 staff member at the outlet. If the respondent does not know the answer to a question in this section, ask to speak with another staff member who can provide the information. D1. Does this outlet/facility have disposable gloves available today for staff to use when seeing customers/patients? 1 = Yes 0 = No 8 = Don’t know D2. Does this outlet/facility have a sharps container, also called a sharps disposal box or safety box, available today for staff to use? [___] 1 = Yes 0 = No 8 = Don’t know D2a. How does this facility dispose used sharps such as needles? Do not read list. Circle ALL responses given [___] Pay another facility to incinerate Incinerate within the facility Bury Other(specify)[___________________________________] D3. Is malaria microscopic testing available here today? 1 = Yes 0 = No A B C D [___] go to D7 D4. How many people were tested for malaria at this facility/outlet using microscopy within the past 7 days? 997 = Refused 998 = Don’t know [___|___|___] D5. What is the total cost for a microscopic test for malaria for an adult: [___|___|___|___] KSH Free = 0000; NA =9995; Refused = 9997; Don’t know=9998 D6. What is the total cost for a microscopic test for malaria for a child under five: [___|___|___|___] KSH Free = 0000; NA = 9995; Refused = 9997; Don’t know=9998 D7. Malaria rapid diagnostic tests, also called RDTs, are small, individually wrapped blood tests that are able to quickly diagnose whether a person has malaria. Show RDT images in prompt card Are malaria RDTs available here today? 1 = Yes 0 = No Don’t know [___] go to D9 ask to speak with a respondent who has this information D8. Please show us the full range of RDTs that you currently have in stock. Do you currently have any of the following? Read entire list; No response to be recorded. SD Bioline, SD Malaria Antigen, U-Test Malaria Wondfo One Step, Nova Test First Response, ParaCheck, CareStart Proceed to the RDT audit. If additional audit sheets are used, add these sheets after the ones provided and staple the questionnaire again. All pages should be in order before you move onto the next outlet. Number each RDT by assigning a Product Number. Number each audit sheet used in the spaces provided at the bottom of the page. Complete the Sub-outlet Code as well as the Product Number for each RDT audited. Sub-outlet codes are listed on page 3. www.ACTwatch.info Page 126 RAPID DIAGNOSTIC TEST AUDIT SHEET (RDT) OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Sub-outlet code 1. Brand name 2. Antigen test (circle ALL that apply) [_____] Product number Not indicated Z HRP2 A 3. Parasite species (circle ALL that apply) Not indicated Z Pf A Pv B Po C pm D pan E vom/Pvom F Other G pLDH B Aldolase C [__|__|__] 4. Manufacturer 5. Country of Manufacture 6. Lot Number Refused = 9997; Don’t know=9998 [___] 8. What is the name of your supply company for this product? Record name. 9. When did you first receive or place an order for this product? Record month and year. [_________________________________] [___|___| - |__2_|_0_|___|___] Month - Year 14a. Do you or other staff use this brand of RDT to test clients here at this facility/outlet? 1 = Yes 0 = No go to 15a 8 = Don’t know go to 15a 15a. Does this facility/outlet provide this brand of RDT for clients to take away for testing somewhere else? 1 = Yes 0 = No go to 16 8 = Don’t know go to 16 10. What was the date of your most recent order for this product? Record month and year. [___|___| - |_2_|_0_|___|___] Month - Year 16. Wholesale purchase price For the outlet’s most recent wholesale purchase: [___|___|___|___] tests [___] [___] 14b. If yes, what is the total cost for an adult to have a test conducted with this RDT, including RDT cost and service fee? 15b. If yes, what is cost of this RDT for an adult? [___|___|___|___] KSH [___|___|___|___] KSH 14c. If yes, what is the total cost for a child under the age of five to have a test conducted with this RDT, including RDT cost and service fee? 1 = Yes 0 = No 8 = Don’t know Not indicated = 998 Specify [_____________________] 7. Does the product have a checkmark logo? Show prompt card. 1=Yes 0=No go to 12 8=Don’t know go to 12 [___] 12. Number of tests 13. Has sold/ distributed this test /used in the last 7 been days to individual stocked consumers out at any (Record total # of point in tests) the past 3 This outlet sold or months? distributed 1 = Yes 0 = No [___|___|___|___] 8 = Don’t tests in the last 7 know days 7a. Is this a self test kit, with each test kit copackaged with its own buffer, pipette and lancet? 15c. If yes, what is the cost of this RDT for a child under the age of five? [___|___|___|___] KSH [___|___|___|___] KSH cost [___|___|___|___|___] KSH Free = 00000 NA = 99995 Refused = 99997 Don’t know=99998 [___] 11. How many RDT cassettes did you purchase/receive for your most recent order ? [___|___|___|___] Refused = 9997 ; Don’t know = 9998 17. Why do you stock this RDT [SHOW RDT]? Do not read list Circle ALL responses given Free supply A Profitable B Recommended by the government C Low price D Customer demand or preference E Positive brand reputation F Don’t know X Other Z specify [_______________________________] Free = 0000; NA = 9995; Refused = 9997; Don’t know=9998 www.ACTwatch.info Page 127 18. Com ment OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] RDT stock outs D9. Are there any malaria RDTs that are out of stock today, but that you stocked in the past 3 months? 1 = Yes 0 = No 8 = Don’t know [___] go to D11 go to D11 D10. What are the brand names of the malaria RDTs that are out of stock? Record one brand per line. 1 = Yes, specify [____________________________________________________________________________] [___] [____________________________________________________________________________] [____________________________________________________________________________] 0 = No D11. Does this facility/outlet provide medicines or prescription for medicines? 1 = Yes 0 = No go to Section 5: Provider Module Confirm response in S3 or S4 is not equal to 1 and outlet type recorded in C7 is 18 or 19 (“lab only”). Go to Section 7: ORS and ZINC and then Go to Section 6: Audit Tracking Sheet. www.ACTwatch.info [___] Page 128 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Section 5: Provider Module This section is for the senior-most staff member who is responsible for providing treatment, prescriptions or medicines to clients/patients. P1. Do your responsibilities at this outlet/facility include: providing prescriptions, treatment, or medicines to clients? |___] 1 = Yes No ask to speak with the senior-most person at the outlet with 1 or more of these responsibilities. P2. For how many years have you worked in this outlet/facility? If less than 1 year, enter 01 [___|___] P3. What age are you today? Write age in years 97 = Refused 98 = Don’t know [___|___] P4. Don’t read: Is respondent male or female? [___|___] 1 = Male 2 = Female P5. What is the highest level of education you completed? 1 2 3 4 5 6 7 = = = = = = = No formal education Some primary school Completed primary school Some secondary school Completed secondary school Some university/college Completed a university/college degree [___] P6. Have you received any training in the last 12 months that included a component on malaria diagnosis, including malaria rapid diagnostic tests or microscopy? Include pre-service training and stand-alone workshops. [___] 1 = Yes 0 = No 8 = Don’t know P7. Have you received any training in the last 12 months on the national treatment guidelines for malaria? Include pre-service training and stand-alone workshops. [___] 1 = Yes 0 = No 8 = Don’t know P8. Do you have any of the following health qualifications? Read list. Record 1 for yes, 0 for no I. IV. Pharmacist [___] II. Medical doctor [___] III. Clinical Officer [___] Nurse / Nursing Officer [___] Midwife [___] Laboratory technician / Lab assistant V. [___] VII. Pharmaceutical technologist [___] VIII. Registered Pharmacy technician [___] IX. Public Health Technician/Officer [___] Medical assistant / Nursing Assistant / Nursing Aid [___] Community based distributor/Community Health Worker [___] Other 1: specify [______________________________] [___] VI. X. XI. XII. www.ACTwatch.info Page 129 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P9. Not including yourself, do any other people working in this outlet or facility have the following health qualifications? Read list. Record 1 for yes, 0 for no, 8 for don’t know I. IV. Pharmacist [___] II. Medical doctor [___] III. Clinical Officer [___] Nurse / Nursing Officer [___] V. Midwife [___] Laboratory technician / Lab assistant [___] VII. Pharmaceutical technologist [___] VIII. Registered Pharmacy technician [___] IX. Public Health Technician/Officer [___] Medical assistant / Nursing Assistant / Nursing Aid [___] Community based distributor/Community Health Worker [___] XII. Other 1: specify [______________________________] [___] XIII. Other 2: specify [______________________________] [___] XIV. Other 3: specify [______________________________] [___] VI. X. XI. Interviewer: For the following questions record the antimalarial brand name or generic name, and dosage form, in the spaces provided. Ask the provider to show you the medicine if it is in stock to verify the name and dosage form. P10. In your opinion, for treating uncomplicated malaria in adults, what is the most effective antimalarial medicine? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [______________________________________] [___|___] Don’t know = 98 P11. In your opinion, for treating uncomplicated malaria in children under five, what is the most effective antimalarial medicine? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [_______________________________________] Don’t know = 98 [___|___] www.ACTwatch.info Page 130 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P12. What antimalarial medicine for treating uncomplicated malaria in adults do you most often recommend to customers? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [______________________________________] [___|___] Don’t know = 98 P13. What antimalarial medicine for treating uncomplicated malaria in children under five do you most often recommend to customers? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [______________________________________] [___|___] Don’t know = 98 P14. In your opinion, for treating severe malaria in children under five, what is the most effective antimalarial medicine? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [_____________________________________] [___|___] Don’t know = 98 P15. What antimalarial medicine for treating severe malaria in children under five do you most often recommend to customers? Ask the provider to show you the medicine if it is in stock. Generic or brand name Dosage form/formulation 01 = Tablet 04 = Syrup 07 = Drops 02 = Suppository 05 = Suspension 95 = None specified 03 = Granule 06 = IM/IV Injection 98 = Don’t know (liquid or powder) [_____________________________________] [___|___] Don’t know = 98 www.ACTwatch.info Page 131 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P16. Please name the first line medicine recommended by the government to treat uncomplicated malaria. Do not read list. Only one response allowed. 01 = Artemether Lumefantrine (Lonart, Artefan, Lumartem, Coartem) …………………………… Go to P17 02 = ACT................................................................................................................................ Go to P17 03 = ACTm............................................................................................................................. Go to P17 04 = Artesunate Amodiaquine (DUAC, Coarsucam, Winthrop) 05 = Dihydroartemisinin Piperaquine (Duo-cotecxin, P-alaxin) 06 = Amodiaquine 07 = Artemether 08 = Artemisinin 09 = Artesunate Go to P19 10 = Chloroquine 11 = Quinine 12 = Sulfadoxine Pyrimethamine (Fansidar, SP, Orodar, Ekelfin, Metakelfin) 96 = Other specify: [______________________________________________] 98 = Don’t know [___|___] P17. Please explain the government recommended treatment regimen for this drug for an adult (60kg) Read the following 3 questions to the provider I. How many tablets should they take at a time? [___|___].[___|___] II. How many times per day? [___|___] III. Over how many days? [___|___] Non-tablet = 94 NA = 95 Don’t know = 98 If respondent has the medicine available use the package to complete the table below. If the medicine is not available ask respondent to identify from prompt card. If identification not possible, ask respondent to recall medicine details. Generic name Strength in mg Brand name [__|__] _______________________________ [__|__|__].[__]mg [__|__] _______________________________ [__|__|__].[__]mg [__|__] _______________________________ [__|__|__].[__]mg [___|___] Manufacturer Don’t know=999.8 Is this drug a fixed-dose combination 1 = Yes 0 = No 8 = Don’t know [___] Don’t know = 98 www.ACTwatch.info Page 132 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P18. Please explain the government recommended treatment regimen for this drug for a 2-year old child (10kg) Read the following 3 questions to the provider I. How many tablets should they take at a time? [___|___].[___|___] II. How many times per day? [___|___] III. Over how many days? [___|___] Non-tablet = 94 NA = 95 Don’t know = 98 If respondent has the medicine available use the package to complete the table below. If the medicine is not available ask respondent to identify from prompt card. If identification not possible, ask respondent to recall medicine details. Generic name Strength in mg Brand name [__|__] _______________________________ [__|__|__].[__]mg [__|__] _______________________________ [__|__|__].[__]mg [__|__] _______________________________ [__|__|__].[__]mg [___|___] Manufacturer Don’t know=999.8 Is this drug a fixed-dose combination 1 = Yes 0 = No 8 = Don’t know [___] Don’t know = 98 P19. Please name the medicine recommended by the government to treat severe malaria. Do not read list. Only one response allowed. 01 = Artesunate (Artesun, Larinate) ……………………………………………………………………………. Go to P20 02 = Artemether (Artenam, Paluther., Artesiane, Larither) ...................... Go to P20 03 = Quinine...................................................................................................................... Go to P20 04 = ACT/ACTm 05= Artemether Lumefantrine (Lonart, Artefan, Lumartem, Coartem) 06 = Artesunate Amodiaquine (DUAC, Coarsucam, Winthrop) 07 = Dihydroartemisinin Piperaquine (Duo-cotecxin, P-alaxin) Go to P21 08 = Chloroquine 09 = Sulfadoxine Pyrimethamine (Fansidar, SP, Orodar, Ekelfin, Metakelfin) 96 = Other (specify): [ _________________________________________] 98 = Don’t know P20. What is the dosage form/formulation medicine recommended by the government to treat severe malaria? Do not read dosage form options 01 = Tablet 02 = Suppository 03 = Granule 04 = Syrup 05 = Suspension 06 = IM/IV Injection (Liquid or powder) 07 = Drops 95 = None specified 98 = Don’t know www.ACTwatch.info [___|___] [___|___] Page 133 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P21. Malaria rapid diagnostic tests, also called RDTs, are small, individually wrapped blood tests that are able to quickly diagnose whether a person has malaria. Show RDT images in prompt card Have you ever seen or heard of malaria RDTs? 1 = Yes 0 = No 8 = Don’t know [___] Go to P22 Go to P29 Go to P29 P22. Have you ever tested a client for malaria using an RDT? 1 = Yes 0 = No 8 = Don’t know [___] P23. Would you ever recommend a patient/customer take an antimalarial if a blood test using a rapid diagnostic test produced a negative test result for malaria? Read list. Record only one response. 1 = Yes, Sometimes 2 = Yes, Always 3 = No, Never 8 = Don’t know [___] go to P25 go to P25 P24. Under what circumstances would you recommend a patient/customer take an antimalarial following a negative RDT test for malaria? Do not read list. Prompt “anything else” until the respondent is finished. Circle ALL responses given When they have signs/symptoms of malaria When they ask for antimalarial treatment When they are a child When they are an adult When they are a pregnant woman When I do not trust/believe the test When I know the patient/customer Other (specify) [_______________________________________________] A B C D E F G X P25. Have you ever seen or heard about the RDT with a checkmark logo before? Show the RDT with the checkmark logo 1= Yes 0= No go to P29 98= Don’t know go to P29 P26. Where did you see or hear about the RDT with a checkmark logo? Do not read list. Circle ALL that apply [___] I attended a training A My colleague in this outlet attended a training B Brochure/booklet/job aid C Billboard D Poster E Distributor/supplier F From the RDT product G Radio H Colleague I Nearby facility J K Other (specify): [___________________________________________] www.ACTwatch.info Page 134 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] P27. Do you have any posters, brochures, or other job aids available here that describe malaria testing with an RDT? 1=Yes 0=No 8=Don’t know [___] go to P29 go to P29 P28. Ask to see the materials. Does the RDT with the checkmark logo appear on any of the materials? [___] 1=Yes 0=No 8=Don’t know P29. What are the danger signs of severe illness in a child under 5? Do not read list. Prompt “anything else” until the respondent is finished. Circle ALL responses given A Unable to drink /unable to breastfeed B Vomits everything C Convulsions D Lethargic or unconscious Z Don’t know Other (specify) [__________________________________________________________] X P30. What would you do if a 2-year old child was brought to this outlet with the danger signs of severe illness? Do not read list. Only one response allowed. 01 = Seek advice/help from someone in this facility 02 = Treat the child in this facility 03 = Refer to a health facility (clinic, hospital) with or without treating here [___|___] 04 = Refer to a non health facility outlet (not a clinic or hospital) with or without treating here 05 = Send them away/home without medicine 06 = Send them away/home with medicine 96 = Other – specify: [__________________________________________________________] 98 = Don’t know Complete the audit sheet tracker on the next page then follow the instructions for ending the interview. www.ACTwatch.info Page 135 OUTLET ID: [___|___]-[___|___]-[___|___|___]-[___|___|___|___]-[___|___|___] Section 6: Audit Tracking Sheet T1. Were there any antimalarial TABLETS/SUPPOSITORIES/GRANULES in stock at this outlet? 1 = Yes 0 = No go to T4 8 = Don’t know go to T4 [___] T2. Total number of TABLET/SUPPOSITORY/GRANULE audit sheets completed [___|___] T3. Did you complete audit sheet information for all available TABLETS/SUPPOSITORIES/GRANULES? 1 = Yes, audit complete 0 = No, audit not complete [___] T4. Were there any antimalarial NON TABLETS (Syrups, suspensions, Injectables) in stock at this outlet? 1 = Yes 0 = No go to T7 8 = Don’t know go to T7 [___] T5. Total number of NON-TABLET audit sheets completed [___|___] T6. Did you complete audit sheet information for all available NON-TABLETS? 1 = Yes, audit complete 0 = No, audit not complete [___] T7. Were there any RDTs in stock at this outlet? 1 = Yes 0 = No go to T10 8 = Don’t know go to T10 [___] T8. Total number of RDT audit sheets completed [___|___] T9. Did you complete audit sheet information for all available RDT? 1 = Yes, audit complete 0 = No, audit not complete [___] T10. COMMENTS: Reason for incomplete audit sheets (if response is no to T3, T6, or T9): THANK THE PROVIDER FOR THEIR PARTICIPATION Return to C9 and record the final status of the interview and time completed. Then complete Section 7: ORS and Zinc and Section X: Ending the Interview. www.ACTwatch.info Page 136 Annex 7: Antimalarial Reference Table X3: Number of antimalarials audited Urban Public Health Facility Community Health Worker Privatenotforprofit ALL Public / Not forprofit Private forprofit HF Registered Pharmacy Unregistered Pharmacy General retailer Total Private ALL Outlets 622 3 102 727 1124 3401 2181 110 6816 7543 Census 215 3 102 320 1124 1530 2181 110 4945 5265 Booster 407 0 0 407 0 1871 0 0 1871 2278 Rural 1108 31 61 1200 237 294 410 215 1156 2356 Census 251 31 61 343 237 129 410 215 991 1334 Booster 857 0 0 857 0 165 0 0 165 1022 1730 34 163 1927 1361 3695 2591 325 7972 9899 TOTAL Source: ACTwatch Outlet Survey, Kenya, 2014. Table X4: Quality-Assured (QA ACT) and Non-Quality Assured ACTs Quality-Assured ACT (QA ACT) QA ACTs are ACTs that comply with the Global Fund to Fight AIDS, Tuberculosis and Malaria’s Quality Assurance Policy. A QA ACT is any ACT that appeared on the Global Fund's indicative list of antimalarials meeting the Global Fund's quality assurance policy * prior to data collection, or that previously had C-status in an earlier Global Fund quality assurance policy and was used in a program supplying subsidized ACTs. QA ACTs also include ACTs that have been granted regulatory approval by the European Medicines Agency (EMA)** – specifically Eurartesim® and Pyramax®. Artesunate Amodiaquine Tablets Winthrop Infant 2-11 months # Winthrop Toddler 1-5 years # Winthrop Child 6-13 years # Winthrop Adult +14 years # Artesun- Plus 2-11 months # Artesun- Plus 1-5 years # Artesun- Plus >14 years # Artemether Lumefantrine Tablets Artefan 20/120 5-14kg Dispersible ^# Artefan 20/120 15-24kg Dispersible ^# Artefan 20/120 25-34kg ^# Artefan 20/120 35+ Kg Adults ^# Artemether + Lumefantrine <3years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine 3-8years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine 9-14years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine >14 years (IPCA Laboratories LTD) ^# Co-Falcinum 5-14 Kg ^ Co-Falcinum 15-24 Kg ^# Co-Falcinum 25-34 Kg # Co-Falcinum 35Kg and above ^# Artemether Lumefantrine Tablets Coartem Dispersible 5-14kg ^# Coartem Dispersible 15-25kg ^# Coartem 20/120 25-35 Kg ^# Coartem 20/120 35 Kg+ ^# Combiart 20/120 ^# Combiart 20/120 5-15 Kg# Lumartem 15 To <25kg (Cipla Pharma LTD) # Lumartem 35kg and above (Cipla Pharma LTD) ^# Lumerax 20/120 # Lumet # Non-Quality-Assured ACT ACTs that do not meet the definition of being quality-assured. Artemether Lumefantrine Tablets Altem # Artefan 40/240 # Dihydroartemisinin Piperaquine Tablets Co-malasinin 40/320 # D-artepp 40mg/320mg # www.ACTwatch.info Page 137 Table X4: Quality-Assured (QA ACT) and Non-Quality Assured ACTs Artefan 80/480 # Coartem 80/480 35 kg + # Co-corither DS 35kg + # Cofantrine Forte # Co-max # Lamitar AM ^ Lonart Tablets # Lonart DS ^# Lonart Forte # Lum-artem 20/120 (Dawa Limited) # Lumesoft plus # Luteriam # Lumether # Artesunate Sulfadoxine Pyrimethamine Tablets Co-arinate FDC Adult ^# Co-arinate FDC Junior # Darte-q # Duo-cotexcin Children 5-20kg # Duo-cotecxin 40/320 ^# Duotab ^# Malacur 40/320 # P-Alaxin 40/320 ^# Ridmal 40/320 # Artemether Lumefantrine Suspension Artefan Suspension ^# Co-Artesiane Pediatric ^# Co-corither Pediatric # Co-max # Lonart 20/120 Pediatric ^# Lum-artem Children 1-5 Years (Dawa Limited) # Lumether # Artemisinin Naphthoquine Tablets Arco ^# Dihydroartemisinin Piperaquin Suspension Malacur for Infants and Children ^# P-Alaxin Pediatric Suspension ^# Artemisinin Piperaquine Tablets Artequick ^# Artemether Lumefantrine Suppository Lonart # Artesunate Amodiaquine Tablets Arenax # Dihydroartemisinin Piperaquin Granules Darte-q paediatric # Artesunate Mefloquine Tablets Artequin 300/375 child # Artequin 600/750 adult ^# Artesunate Mefloquine Granules Artequin paediatric # * http://www.theglobalfund.org/en/procurement/quality/pharmaceutical **http://www.ema.europa.eu/ ^ Product audited in the public sector # Product audited in the private sector www.ACTwatch.info Page 138 Table X5: Nationally Registered ACTs ACT registered with Kenya’s national drug regulatory authority and permitted for sale or distribution in Kenya. Artesunate Amodiaquine Tablets Artemether Lumefantrine Tablets Winthrop Adult +14 Years # Coartem Dispersible 5-14kg ^# Winthrop Child 6-13 Years # Coartem Dispersible 15-25kg ^# Winthrop Infant 2-11 Months # Coartem 20/120 25-35 Kg ^# Winthrop Toddler 1-5 Years # Coartem 20/120 35 Kg+ ^# Co-falcinum 5-14kg ^# Artesunate Sulfadoxine Pyrimethamine Tablets Co-falcinum 15-24kg ^# Co-arinate FDC Adult ^# Co-falcinum 25-34kg # Co-arinate FDC Junior # Co-falcinum 35kg And Adults ^# Co-max # Artemisinin Piperaquine Tablets Lonart # Artequick ^# Lonart Ds ^# Lonart Forte # Dihydroartemisinin Piperaquine Tablets Lum-Artem 20/120 (Dawa Limited) # D-Artepp 40mg/320mg # Lumartem 15 To <25kg (Cipla Pharma LTD) # Malacur 40/320 # Lumartem 35kg And Above (Cipla Pharma LTD) ^# P-Alaxin 40/320 ^# Lumerax 20/120 ^# Ridmal 40/320 # Artemether Lumefantrine Suspensions Artesunate Mefloquine Tablets Artefan Suspension ^# Artequin 300/375 Child # Lonart Paediatric ^# Artequin 600/750 Adult ^# Lum-artem Children 1-5 Years (Dawa Limited) # Artemether Lumefantrine Tablets Dihydroartemisinin Piperaquine Suspensions Altem # P-Alaxin Pediatric Suspension ^# Artefan 20/120 5-14kg Dispersible ^# Artefan 20/120 15-24kg Dispersible ^# Artefan 20/120 25-34kg ^# Artefan 20/120 35+ Kg Adults ^# Artefan 40/240 # Artefan 80/480 # Artemether + Lumefantrine <3years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine 3-8years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine 9-14years (IPCA Laboratories LTD) ^# Artemether + Lumefantrine >14 years (IPCA Laboratories LTD) ^# ^ # Product audited in the public sector Product audited in the private sector www.ACTwatch.info Page 139 Table X6: Severe Malaria Treatment WHO recommends parenteral artesunate as first-line treatment in the management of severe falciparum malaria, with artemether or quinine injections as acceptable alternatives if parenteral artesunate is not available*. If complete treatment for severe malaria is not possible, patients with severe malaria should be given pre-referral treatment and referred immediately to an appropriate facility for further treatment. The following are options for pre-referral treatment: rectal artesunate, injectable quinine, injectable artesunate, injectable artemether, and injectable arteether/artemotil. Quinine Liquid Injection (Manufacturer) Agenquine Injection (Shandong Xier Kangali Pharmaceutical Co. Ltd) ^# Kwinil (Intas Pharmaceuticals Ltd) # Artemether Liquid Injection (Manufacturer) Laquine Injection (Cosme Limited) ^# Artesiane 100 (Dafra Pharma Gmbh) ^# Megaquin Injection (Royal Group) # Artesiane 80 (Dafra Pharma Gmbh) ^# Mosqun Injection (Indus Pharma (Pvt) Ltd) ^# Artesiane 40 (Dafra Pharma Gmbh) # Quinine Dihydrochloride (Laborate Pharmaceutical) ^# Corither AB (Coral Laboratories Ltd) # Falcinum 40 (Cipla Ltd) # Quimed Injection (Syner-Med Pharmaceutical Ltd) ^# Quinine Dihydrochloride (Rotexmedica Gmbh Arzneimittelwerk) ^# Quinine Dihydrochloride (Intas Pharmaceutical Ltd) # Artenam 100 (Arenco Pharmaceutical) ^# Artenam 40 Paediatric (Arenco Pharmaceutical) # Falcinum 80 (Cipla Ltd) # Quinine Dihydrochloride (Gland Pharma Ltd) ^# Glinther (Guilin Pharmaceutical Co Ltd) # Gvither 20 Injection (Bliss Gvs Pharma Ltd) ^# Quinine Dihydrochloride (Systochem Laboratories Ltd) # Gvither 40 Injection (Bliss Gvs Pharma Ltd) ^# S-Quin Injection (Swiss Parenteral Pvt Ltd) ^# Gvither Forte Injection (Bliss Gvs Pharma Ltd) ^# Arteether/Artemotil Liquid Injection (Manufacturer) Indomal Injection (Indus Pharma (Pvt) Ltd) # Larither 40 (IPCA Laboratories Ltd) ^# Artimal (Indi Pharma Pvt Ltd) # Larither 80 (IPCA Laboratories Ltd) ^# Emal Injection (Themis Medicare Ltd) # Malgo 80mg (Ccl Pharmacetical (Pvt) Ltd)# Malither Injection (Themis Medicare Ltd) # Artesunate Powder Injection (Manufacturer) Syn-Mal 80mg (Swiss Parenteral Pvt Ltd) # Artesun 120mg (Guilin Pharmaceutical Co Ltd) ^# Tether 80mg (Luckon Pharmaceuticals) # Artesun 30mg (Guilin Pharmaceutical Co Ltd) # Artesun 60mg (Guilin Pharmaceutical Co Ltd) ^# Artemether Liquid Injection (Manufacturer) Artem (Kunming Pharmaceutical Corp) # Artemal-M Injection (Plethico Pharma Ltd) ^# Artemedine (Kunming Pharmaceutical Corp) # Artemether Injection (Jiangsu Ruinian Qianjin Pharmaceutical Co, Ltd) # * Guidelines for the treatment of malaria, 2nd edition – revision 1.WHO. Geneva: 2010. ^ Product audited in the public sector # Product audited in the private sector www.ACTwatch.info Page 140 Annex 8: RDT Reference Table X7: Number of RDTs audited Urban Public Health Facility Community Health Worker Private Not-forProfit Facility Private for-profit HF Registered Pharmacy Unregistered Pharmacy General retailer ALL Outlets 113 3 11 111 67 67 0 372 Census 35 3 11 111 21 67 0 248 Booster 78 0 0 0 46 0 0 124 Rural 221 19 8 25 3 6 0 282 Census 49 19 8 25 1 6 0 108 Booster 172 0 0 0 2 0 0 174 334 22 19 136 70 73 0 654 TOTAL Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 141 Table X8: RDT Brand Names and Manufacturers* Brand Name Manufacturer A Con # A Con Laboratories Inc Abon ^# Abon Biopharm (Hangzhou) Co. Ltd Artron # Artron Laboratories Inc Carestart ^# Access Bio Inc. Dvg Deangel Biological # Hang Zhou Deangel Biological Engineering Co Ltd Ezdx ^# Advy Chemical First Response # Premier Medical Corporation Ltd Humasis ^# Humasis Co. Ltd Ict # Ict Diagnostics Immunoquick ^ Biosynex Makesure # Hll Lifecare Limited Malacur # Blue Cross Bio-Medical (Beijing)Co Ltd Malaria Self Test # Ict Diagnostics Malarigen # Aspen Laboratories Pvt Ltd One Step Malaria (P.F.) Test # Blue Cross Bio-Medical (Beijing)Co Ltd One Step Malaria (P.F.) Test # Humasis Co. Ltd One Step Test ^ Intec Products Inc. Onsite # Ctk Biotech Inc. Paracheck ^# Orchid Biomedical Systems Parahit # Signature Healthcare Ltd Parascreen # Zephyr Biomedicals Sd Bioline ^# Standard Diagnostics Inc. Wondfo # Wondfo Biotech Co Ltd * 654 RDTs were audited. No RDTs were missing brand name information (missing or don’t know). 8 were missing manufacturer name (missing or don’t know). ^ Product audited in the public sector # Product audited in the private sector www.ACTwatch.info Page 142 Annex 9. Sampling Weights Sampling weights were applied for analysis of the Kenya 2014 outlet survey data to account for variations in probability of selection as a result of the sampling design: 1) Stratification: Disproportionate allocation stratification was used to ensure adequate sample size within the urban and rural domains to allow for domain-specific estimates. The research domains were based on national designation of urban and rural wards. A representative sample was selected within each domain. 2) One-stage cluster sampling: Locations were selected from sampling frames within each domain with probability proportional to size. Within each location, a census of all outlets with the potential to sell or distribute antimalarials and/or provide malaria blood testing was conducted. 3) Booster sample – public health facilities (PHFs) and pharmacies: The geographic area for the outlet census was extended to the division level for public health facilities and pharmacies. All public health facilities and pharmacies within divisions in which the selected locations were located were included in the study. The sampling weights applied during analysis are the inverse of the probability of selection: 𝑊𝑖 = 1 a × Mα ∑ Mα Where: Mα = ΣMα = a= estimated cluster (population size) sum of estimated cluster sizes (population size) in the entire stratum number of clusters selected within the stratum Sampling weights are calculated at the cluster level and are applied to all outlets within a given cluster, irrespective of outlet type. Market share was calculated using the full census data at the location level only (i.e. the booster sample was not included in market share calculations). Ward sampling weights were created using the sampling weight formula (Wi), where: Mα = ΣMα = a= estimated ward population size sum of estimated location population size in the entire stratum number of locations selected within the stratum The ward sampling weights were applied to all other indicators in the report for all outlet types with the exception of: 1. Public health facilities and pharmacies: Given that PHFs and pharmacies were included in the sample through a division-wide census, the weights applied to PHFs and pharmacies for all indicators other than market share were calculated using the sampling weight formula (Wi), where: Mα = estimated division population size ΣMα = sum of estimated division population size in the entire stratum a= number of divisions selected within the stratum www.ACTwatch.info Page 143 The population estimates used to select wards with PPS and to create sampling weights were obtained from the 1999 National Census. A sampling frame with population sizes was used for selecting the sample because accurate estimates on the total number of outlets per geographic/administrative unit that may be eligible for a medicine outlet survey do not exist. The major assumption in using population figures for sampling and weighting is that distribution of outlets and/or distribution of medicines moving through outlets in a given cluster is correlated with population size. www.ACTwatch.info Page 144 Annex 10: Indicator Definitions Table definitions below are reflective of the corresponding table numbers in each results section above (Table 1 definition corresponds to Table A1, Table B1, Table C1, etc.) Table 1: Availability of antimalarials, among all screened outlets Table 1 reports the proportion of all outlets enumerated that had any antimalarial in stock at the time of the survey visit. Antimalarial availability is reported among all outlets as well as among individual outlet types, all public outlets, and all private outlets. Availability is reported for any antimalarial as well as specific types of antimalarial medicines. Numerator Number of outlets with any antimalarial in stock at the time of the survey visit, as confirmed by presence of at least one antimalarial (defined as a medicine with antimalarial ingredients) recorded in the antimalarial audit section. Denominator Number of outlets screened. Calculation Numerator divided by denominator. Handling missing values All screened outlets will contribute to the denominator. This includes outlets that were eligible for interview (including antimalarial audit) but: 1) were not interviewed; or 2) the interview was partially completed. Notes and considerations Given partial or non-completion of interviews among eligible outlets and the inclusion of these outlets in the denominator, these availability indicators can be considered conservative estimates of antimalarial availability. Table 2: Availability of antimalarials, among outlets stocking at least one antimalarial Table 2 reports the proportion of antimalarial-stocking outlets with specific antimalarial in stock at the time of the survey visit. Antimalarial availability is reported among all outlets as well as among individual outlet types, all public outlets, and all private outlets. Availability is reported for any antimalarial as well as specific types of antimalarial medicines. Numerator Number of outlets with any antimalarial in stock at the time of the survey visit, as confirmed by presence of at least one antimalarial (defined as a medicine with antimalarial ingredients) recorded in the antimalarial audit section. Denominator Number of outlets with at least 1 antimalarial audited. Calculation Numerator divided by denominator. Handling missing values All outlets with at least one antimalarial recorded in the antimalarial audit sheet will contribute to the denominator. This includes outlets where the interview was not fully completed (partial interview). Notes and considerations Given partial completion of interviews among antimalarial-stocking outlets and the inclusion of these outlets in the denominator, these availability indicators can be considered conservative estimates of antimalarial availability. www.ACTwatch.info Page 145 Table 3: Antimalarial market composition Table 3 reports the distribution of outlet types among outlets with at least one antimalarial in stock on the day of the survey. Numerator By outlet type, the number of outlets with any antimalarial in stock at the time of the survey visit, as confirmed by presence of at least one antimalarial (defined as a medicine with antimalarial ingredients) recorded in the antimalarial audit section. Denominator Total number of outlets with any antimalarial in stock at the time of the survey visit, as confirmed by presence of at least one antimalarial (defined as a medicine with antimalarial ingredients) recorded in the antimalarial audit section. Calculation Numerator for each outlet type divided by the denominator. Handling missing values All outlets with at least one antimalarial recorded in the antimalarial audit sheet will contribute to the indicator. This includes outlets where the interview was not fully completed (partial interview). Notes and considerations Market composition is calculated among outlets located within the representative sample of clusters, and excludes the booster sample. Table 4: Price of antimalarials Table 4a provides the median price of an adult equivalent treatment dose (AETD, see Annex 11) for select tablet formulation types of antimalarials across outlet types. The inter-quartile range (IQR) is provided as a measure of dispersion. Calculation Median antimalarial AETD (see Annex 11) price in US dollars with inter-quartile range (25th and 75th percentiles). Handling missing values Antimalarials with missing price information are excluded from the median price calculation. Notes and considerations Price in US dollars is calculated based on exchange rates available from www.oanda.com using the historical exchange rates tool. The average exchange rate over the entire data collection period is used for converting local currency captured during data collection to US dollars. A. Table 4b reports the median price of one injection of an antimalarial that should be used for severe malaria treatment only (artemether injection, quinine injection). The inter-quartile range (IQR) is provided as a measure of dispersion. B. Table 4b also provides the median price of two pre-packaged QA ACT therapies: pediatric appropriate for a 10kg child (2 years of age), and adult appropriate for a 60kg adult. The inter-quartile range (IQR) is provided as a measure of dispersion. www.ACTwatch.info Page 146 Calculation Median antimalarial injection price in US dollars with inter-quartile range (25th and 75th percentiles). Median pre-packaged therapy price in US dollars with inter-quartile range (25th and 75th percentiles. Handling missing values Antimalarials with missing price information are excluded from the median price calculation. Notes and considerations Price in US dollars is calculated based on exchange rates available from www.oanda.com using the historical exchange rates tool. The average exchange rate over the entire data collection period is used for converting local currency captured during data collection to US dollars. Table 5: Availability of malaria blood testing among antimalarial-stocking outlets Table 5 reports the proportion of antimalarial-stocking outlets that had malaria blood testing available. Testing availability is reported among all outlets as well as among individual outlet types, all public outlets, and all private outlets. Availability is reported for any blood test as well as specific test types: microscopy and rapid diagnostic test (RDT). Numerator Number of outlets with malaria blood testing available (any, microscopy, RDT). Denominator Number of outlets with any antimalarial in stock at the time of the survey visit or reportedly stocked any antimalarial in the previous three months. Calculation Numerator divided by denominator. Handling missing values Notes and considerations Antimalarial-stocking outlets with missing information about both availability of microscopy and availability of RDTs are excluded from this table. The number of such outlets is provided in a footnote. Outlets with partial information about availability of blood testing (information about microcopy or RDTs) are included in the denominator of the indicator “any blood testing available.” The number of such outlets is provided in a footnote. Indicators for RDT and microscopy availability exclude outlets with missing availability information respectively (i.e. outlets missing information about microscopy availability are excluded from the microscopy indicator). Survey inclusion criteria extended to outlets providing blood testing but not stocking antimalarials (“diagnosis/testing-only outlets”). These outlets are excluded from this availability table. www.ACTwatch.info Page 147 Table 6: Malaria blood testing market composition Table 6 reports the distribution of outlet types among outlets with malaria blood testing available on the day of the survey. Numerator By outlet type, the number of outlets with malaria blood testing available at the time of the survey visit, as confirmed by presence of at least one RDT recorded in the RDT audit section and/or reported availability of malaria microscopy services. Denominator Total number of outlets with malaria blood testing available at the time of the survey visit, as confirmed by presence of at least one RDT recorded in the RDT audit section and/or reported availability of malaria microscopy services. Calculation Numerator for each outlet type divided by the denominator. Handling missing values All outlets with non-missing values for the RDT audit or malaria microscopy availability questions are included in the indicators. This includes outlets where the interview was not fully completed (partial interview). Notes and considerations Market composition is calculated among outlets located within the representative sample of clusters, and excludes the booster sample. Table 7: Price of malaria blood testing A. Table 7 reports the median price of blood testing to consumers including any consultation or service fees. The inter-quartile range (IQR) is provided as a measure of dispersion. Calculation Median total blood test price in US dollars with inter-quartile range (25th and 75th percentiles). Handling missing values Microscopy-stocking outlets that are missing information about price of microscopy are excluded from this indicator. Audited RDTs with missing information about price of testing are excluded from this indicator. Notes and considerations Price in US dollars is calculated based on exchange rates available from www.oanda.com using the historical exchange rates tool. The average exchange rate over the entire data collection period is used for converting local currency captured during data collection to US dollars. www.ACTwatch.info Page 148 Table 8: Antimalarial market share Antimalarial market share is the amount of adult equivalent treatment doses (AETD) reportedly sold or distributed in the previous week by outlet type and antimalarial type as a percentage of all AETDs sold/distributed in the previous week. Expressed as a percentage, market share is the amount of a specific antimalarial sold/distributed by a specific outlet type relative to the entire antimalarial market (all antimalarial types sold/distributed by all outlet types). Totals are reported per antimalarial medicine type and per outlet type. Across antimalarial medicine types and outlet types, percentages in the entire table sum to 100% (the total market). Numerator Number of AETDs sold/distributed for a specific antimalarial drug category and outlet type. Denominator Total number of AETDs sold/distributed. Calculation Numerator divided by denominator. Handling missing values AETDs sold/distributed are calculated among audited medicines with complete and consistent information. Antimalarials with incomplete or inconsistent information among key variables that define AETD sold/distributed (active ingredients, strength, formulation, package size, amount sold/distributed) are excluded from the calculation. Notes and considerations See Annex 11 for a description of AETD calculation. Table 9: Antimalarial market share across outlet type Antimalarial market share across outlet type is the amount of adult equivalent treatment doses (AETD) reportedly sold or distributed in the previous week by antimalarial type within each outlet type as a percentage of all AETDs sold/distributed in the previous week within the specified outlet type. Expressed as a percentage, outlet-type market share is the amount of a specific antimalarial sold/distributed relative to the entire antimalarial market segment for the specified outlet type (all antimalarial types sold/distributed by the specific outlet type). Totals are reported per antimalarial medicine type for each outlet type. Across antimalarial medicine types within each outlet type, percentages sum to 100%. Numerator Number of AETDs sold/distributed for a specific antimalarial drug category within the specified outlet type. Denominator Total number of AETDs sold/distributed within the specific outlet type. Calculation Numerator divided by denominator. Handling missing values AETDs sold/distributed are calculated among audited medicines with complete and consistent information. Antimalarials with incomplete or inconsistent information among key variables that define AETD sold/distributed (active ingredients, strength, formulation, package size, amount sold/distributed) are excluded from the calculation. Notes and considerations See Annex 11 for a description of AETD calculation. www.ACTwatch.info Page 149 Table 10: Malaria blood testing market share Malaria blood testing market share is the number of malaria blood tests reportedly sold or distributed in the previous week by outlet type and malaria blood test type (RDT, microscopy) as a percentage of all malaria blood tests sold/distributed in the previous week. Expressed as a percentage, market share is the number of a specific malaria blood test type by a specific outlet type relative to the entire malaria blood testing market (all malaria blood tests sold/distributed by all outlet types). Totals are reported per test type and per outlet type. Across malaria blood test types and outlet types, percentages in the entire table sum to 100% (the total market). Numerator Number of malaria blood tests sold/distributed for a specific blood test type (RDT, microscopy) and outlet type. Denominator Total number of malaria blood tests sold/distributed. Calculation Numerator divided by denominator. Handling missing values Malaria blood tests sold/distributed are calculated among audited RDTs and microscopy services with complete and consistent information. RDTs and microscopy services with incomplete or inconsistent information about the amount sold/distributed) are excluded from the calculation. Notes and considerations Records and/or recall of testing with microscopy versus malaria RDT may differ within a given outlet, introducing an unquantifiable bias in estimating total tests performed. Table 11: Malaria blood testing market share across outlet type Malaria blood testing market share across outlet type is the number of malaria blood tests reportedly sold or distributed in the previous week by blood test type within each outlet type as a percentage of all blood tests sold/distributed in the previous week within the specified outlet type. Expressed as a percentage, outlet-type market share is the amount of a specific malaria blood test sold/distributed relative to the entire blood testing market segment for the specified outlet type (all malaria tests sold/distributed by the specific outlet type). Totals are reported per test type for each outlet type. Across malaria blood test types within each outlet type, percentages sum to 100%. The market share for each RDT manufacturer is also reported across outlet type. Within each outlet type, the number of RDTs for a specific manufacturer sold/distributed relative to all RDTs distributed within that outlet type is reported as a percentage. Totals for RDT market share across all manufacturers sums to 100% within each outlet type. Numerator Number of malaria blood tests sold/distributed for a specific blood test type (RDT, microscopy), or number of malaria RDTs sold/distributed for a specific manufacturer, within the specified outlet type. Denominator Total number of malaria blood tests/RDTs sold/distributed within the specific outlet type. Calculation Numerator divided by denominator. Handling missing values Malaria blood tests sold/distributed are calculated among audited RDTs and microscopy services with complete and consistent information. RDTs and microscopy services with incomplete or inconsistent information about the amount sold/distributed) are excluded from the calculation. Notes and considerations Records and/or recall of testing with microscopy versus malaria RDT may differ within a given outlet, introducing an unquantifiable bias in estimating total tests performed. www.ACTwatch.info Page 150 Table 12: Provider case management knowledge and practices Table 12 reports key indicators of provider case management knowledge and practices. These include referral practices for severe malaria; and self-reported practices for managing clients who test negative for malaria. Numerator A. Referral: respondents who indicated that they would refer to a health facility (response option #3). Note this numerator excludes providers located in a public or private health facility. B. Recommends antimalarials to test-negative clients: respondents who indicated “yes, always,” or “yes, sometimes.” C. Circumstances for recommending an antimalarial: individual indicators for the most common responses provided to this open-ended question. Note this numerator excludes providers who did not respond to the previous question about recommending antimalarials to test-negative clients with “yes, always” or “yes, sometimes.” Denominator A. Referral: respondents who provided a response to this question, including “don’t know.” Note this denominator excludes providers located in a public or private health facility. B. Recommends antimalarials to test-negative clients: respondents who provided a response to this question, including “don’t know.” C. Circumstances for recommending an antimalarial: respondents who provided at least 1 response to this question, including “don’t know” (i.e. at least 1 variable in this series is nonmissing). Note this denominator excludes providers who did not respond to the previous question about recommending antimalarials to test-negative clients with “yes always” or “yes sometimes.” Calculation Numerator divided by denominator. Handling missing values A. Providers missing a response to this question will be excluded from the indicator. B. Providers missing a response to this question will be excluded from the indicator. C. This indicator is assessed using an open-ended multiple response option question. Providers with at least one non-missing response in the variable series for this question will be included in the indicator. Among these sets of responses, missing will be treated as not mentioned. Notes and considerations In some cases, multiple providers were interviewed at one outlet. A provider with responsibilities related to diagnosis may have responded to questions about malaria diagnosis and diagnostics (indicators B and C in Table 9), while a different provider responsible for prescribing and/or dispensing medicines may have responded to questions about danger signs of severe illness and referral for severe malaria (indicator A in Table 8). In all cases, the questions assessing provider knowledge and practices were administered only one time per outlet. As such, indicators are tabulated at the outlet level. www.ACTwatch.info Page 151 Table 13: Provider antimalarial treatment knowledge and practices Table 13 reports key indicators of provider antimalarial treatment knowledge and practices. These include knowledge of the first-line treatment; knowledge of the first-line treatment dosing regimen for adults and children; citing ACT as most effective to treat malaria in adults and children; and citing ACT as most commonly recommended by the provider to manage malaria in adults and children. Numerator Denominator Calculation Handling missing values A. State first-line: providers who responded to p17 with a generic or brand name consistent with a national first-line treatment, or responded to p17 with “ACT,” or “ACTm” and in p18 provided a generic or brand name consistent with a national first-line treatment. In other words, providers must specifically name the first-line treatment using generic or brand name language in either p17 or p18. B. First-line regimen, adult: providers who correctly stated the first-line generic ingredients and strengths in p18, and correctly stated: number of days, times per day, and tablets per dose to be taken. C. ACT most effective, adult & child: Any response for this open-ended question whereby: 1) one medicine or a set of medicines to be used in combination is mentioned only i.e. multiple antimalarial medicines mentioned will be counted as incorrect; and 2) the combination of medicines is an ACT – defined either by using a brand name, generic name, “ACT,” or “ACTm.” If the provider mentions a correct ACT response and also mentioned an anti-pyretic (e.g. paracetamol), this response will be counted as correct. However, if the provider mentions a correct ACT response and also mentioned other drugs – such as an antibiotic – this answer will be counted as incorrect. D. ACT most often recommended, adult & child: Any response for this open-ended question whereby: 1) one medicine or a set of medicines to be used in combination is mentioned only i.e. multiple antimalarial medicines mentioned will be counted as incorrect; and 2) the combination of medicines is an ACT – defined either by using a brand name, generic name, “ACT,” or “ACTm.” If the provider mentions a correct ACT response and also mentioned an anti-pyretic (e.g. paracetamol), this response will be counted as correct. However, if the provider mentions a correct ACT response and also mentioned other drugs – such as an antibiotic – this answer will be counted as incorrect. A. State first-line: All providers who responded to p17 – please name the first-line medicine. B. First-line regimen, adult: All providers who responded to p17 (starting the series on firstline knowledge). C. ACT most effective, adult & child: All providers who responded to p13/14, including providers who responded with “don’t know,” who provided names of non-antimalarial medicines, and who responded with more than one antimalarial medicine not intended to be used as combination therapy. D. ACT most often recommended, adult & child: All providers who responded to p13/14, including providers who responded with “don’t know,” who provided names of nonantimalarial medicines, and who responded with more than one antimalarial medicine not intended to be used as combination therapy. Numerator divided by denominator. A. Providers missing a response to this question will be excluded from this indicator. B. Providers with partial information for the regimen questions will be included in the denominator (i.e. missing treated as not mentioned). C. Providers missing a response to this question will be excluded from the indicator. D. Providers missing a response to this question will be excluded from the indicator. www.ACTwatch.info Page 152 Annex 11. Adult Equivalent Treatment Dose (AETD) Definition Antimalarial medicines are manufactured using a variety of active pharmaceutical ingredients, dosage forms, strengths, and package sizes. ACTwatch uses the adult equivalent treatment dose (AETD) as a standard unit for price and sale/distribution analyses. One AETD is defined as the number of milligrams (mg) of an antimalarial drug required to treat an adult weighing 60 kilograms (kg). For each antimalarial generic, the AETD is defined as the number of mg recommended in treatment guidelines for uncomplicated malaria in areas of low drug resistance issued by the WHO. Where WHO treatment guidelines do not cover a specific generic, the AETD is defined based on peer-reviewed research or the product manufacturer’s recommended treatment course for a 60kg adult. Table X9 lists AETD definitions used in this report. While it is recognized that the use of AETDs may over-simplify and ignore many of the complexities of medicine consumption and use, this analytical approach was selected because it standardizes medication dosing across drug types and across countries (which may sometimes vary) thus permitting comparisons on both prices and volumes calculated on the basis of an AETD. Additional considerations: Where combination therapies consist of two or more active antimalarial ingredients packaged together (coformulated or co-blistered), the strength of only one principal ingredient is used. The artemisinin derivative is used as the principal ingredient for ACT AETD calculations. Co-blistered combinations are generally assumed to be 1:1 ratio of tablets unless otherwise documented during fieldwork or through manufacturer websites. Sulfamethoxpyrazine-pyrimethamine is assumed to have the same full course adult treatment dose as sulfadoxine-pyrimethamine. Calculation Information collected on drug strength and unit size as listed on the product packaging was used to calculate the total amount of each active ingredient found in the package. The number of AETDs in a unit was calculated.31 The number of AETDs in a monotherapy is calculated by dividing the total amount of active ingredient contained in the unit by the AETD (i.e. the total number of mg required to treat a 60kg adult). The number of AETDs for a combination therapy was calculated by dividing the total amount of the active ingredient that was used as the basis for the AETD by the AETD. 31 The unit is dependent on the drug dosage form. The unit for antimalarials in tablet, suppository, or granule form is the package. The unit for injectable antimalarials is the ampoule. The unit for syrup and suspension antimalarials is the bottle. www.ACTwatch.info Page 153 Table X9: Adult Equivalent Treatment Dose Definitions Antimalarial Generic [Ingredient used for AETD mg dose value] Amodiaquine Arteether / Artemotil Artemether Artemether-Lumefantrine [Artemether] Artemisinin-Naphthoquine [Artemisinin] Dose used for calculating 1 AETD (mg required to treat a 60kg adult) Source 1800mg 1050mg 960mg WHO Model Formulary, 2008 WHO Use of Antimalarials, 2001 WHO Use of Antimalarials, 2001 480mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 2400mg WHO Use of Antimalarials, 2001 Artesunate Artesunate-Amodiaquine [Artesunate] Artesunate-Mefloquine [Artesunate] Artesunate- SulfadoxinePyrimethamine [Artesunate] Atovaquone-Proguanil [Atovaquone] Chloroquine 960mg Thanh NX, Trung TN, Phong NC, et al. 2012. The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam. Malaria Journal, 11:217. WHO Use of Antimalarials, 2001 600mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 600mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 600mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 3000mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 1500mg Dihydroartemisinin 480mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 Manufacturer Guidelines (Cotecxin – Holleypharm; MALUether – Euromedi) DihydroartemisininPiperaquine [Dihydroartemisinin] 360mg Artemisinin-Piperaquine [Artemisinin] Hydroxychloroquine Mefloquine Primaquine Quinine Sulfadoxine-Pyrimethamine 504mg 2000mg 1000mg 45mg 10408mg 1500mg WHO Guidelines for the treatment of malaria 2nd edition, 2010 Manufacturer Guidelines (Plaquenil – Sanofi Aventis) WHO Model Formulary, 2008 WHO Guidelines for the treatment of malaria 2nd edition, 2010 WHO Model Formulary, 2008 WHO Model Formulary, 2008 www.ACTwatch.info Page 154 Annex 12: Antimalarial Volumes Table X10: Antimalarial volumes, by outlet type AETDs sold or distributed in the previous week by outlet type and antimalarial type:* Public Health Facility # AETD (95% CI) ALL Public / Not ForProfit # AETD (95% CI) Private For-Profit Facility # AETD (95% CI) 21411.6 28666.5 27435.0 (13047.2, 29776.0) 21261.1 (18967.7, 38365.3) 27600.4 (12897.3, 29624.9) 0.0 130.1 21244.7 Registered Pharmacy Unregistered Pharmacy General retailer TOTAL Private ALL Outlets # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) 59694.7 6544.4 (46432.0, 72957.5) 51031.6 (1884.3, 11204.5) 5977.0 (17928.4, 37272.4) 0.0 1024.1 (341.7, 1706.5) 27016.3 (18522.7, 29347.4) 205.6 (3.7, 407.4) 2311.0 (1590.0, 3032.0) 19800.2 (33035.0, 87500.5) 707.8 (73.1, 1342.6) 13669.1 (6867.4, 20470.9) 49868.4 (40267.7, 61795.6) 297.9 (95.9, 499.9) 6353.7 (4043.9, 8663.5) 46666.4 (1564.2, 10389.8) 32.8 440.4 5040.7 (12879.6, 29609.8) 11032.2 (17321.9, 36710.6) 13824.4 (15361.3, 24239.1) 15887.0 (28025.3, 71711.5) 40544.7 (37148.6, 56184.2) 40384.9 (889.6, 9191.9) 3989.8 (5913.8, 16150.7) 10212.5 (5840.2, 14584.7) 166.9 20670.3 (8141.5, 19507.4) 13159.0 (7658.8, 18659.3) 1650.3 (818.8, 2481.8) 27427.1 (12318.9, 19455.2) 3913.1 (2794.9, 5031.4) 7634.8 (5550.7, 9719.0) 24950.6 (24672.0, 56417.5) 9323.7 (3002.8, 15644.5) 28679.8 (13958.9, 43400.7) 62153.6 (32093.7, 48676.1) 6281.5 (3839.3, 8723.7) 13028.4 (8498.5, 17558.3) 52065.7 (0.0, 8054.1) 1050.9 (0.0, 3039.3) 1503.7 5702.4 (12315.6, 29025.0) 5220.5 (2764.1, 7676.8) 4142.2 (2426.5, 5857.8) 514.3 (100.1, 928.5) 477.3 (196.7, 757.8) (17843.6, 37010.7) 6015.5 (3456.3, 8574.6) 4259.7 (2407.6, 6111.7) 1094.6 (97.0, 2092.2) 553.6 (268.1, 839.1) (19374.9, 30526.4) 5155.7 (4151.4, 6160.1) 4495.3 (3651.8, 5338.9) 130.2 (65.7, 194.6) 318.3 (210.6, 426.1) (31687.6, 92619.5) 36232.2 (20344.5, 52119.9) 33980.8 (19667.0, 48294.6) 635.0 (146.3, 1123.7) 604.7 (0.0, 1217.8) (40545.4, 63585.9) 27276.3 (21134.1, 33418.4) 25723.2 (19826.2, 31620.3) 315.8 (209.6, 422.0) 272.8 (149.9, 395.6) (1573.4, 9831.4) 7471.1 (4659.6, 10282.6) 7266.6 (4602.5, 9930.7) 0.0 2.3 - 172222.4 (127704.1, 216740.6) 141211.5 (107245.6, 175177.4) 1244.1 (522.4, 1965.7) 22774.3 (14604.5, 30944.1) 121375.7 (93393.8, 149357.7) 100806.5 (79164.4, 122448.6) 20569.2 (13184.2, 27954.3) 50846.7 (32850.7, 68842.6) 144872.3 (107490.9, 182253.6) 76135.3 (57265.1, 95005.4) 71465.9 (54206.1, 88725.7) 1081.0 (570.3, 1591.7) 1198.1 (511.1, 1885.1) 200888.9 (21378.1, 33491.9) 23935.1 78548.2 (42642.3, 114454.2) 60267.8 1. Any ACT Artemether Lumefantrine (AL) Artesunate Sulfadoxine Pyrimethamine (ASSP) DHAPPQ Quality Assured ACT (QA ACT) QA ACT with the “green leaf” logo QA ACT without the “green leaf” logo Non-quality-assured ACT (non-QA ACT) Nationally Registered ACT 2. Any non-artemisinin therapy Sulfadoxine-Pyrimethamine Oral Quinine Quinine IV/IM www.ACTwatch.info (150901.5, 250876.3) 168811.9 (129203.6, 208420.2) 1244.1 (522.4, 1965.7) 23798.4 (15505.5, 32091.2) 148392.0 (114362.3, 182421.7) 114630.9 (89053.6, 140208.3) 33728.3 (23609.8, 43846.8) 52496.9 (34187.7, 70806.1) 172299.4 (129816.7, 214782.1) 82150.7 (62899.2, 101402.3) 75725.5 (58320.0, 93131.1) 2175.6 (1046.2, 3305.0) 1751.7 (970.0, 2533.4) Page 155 Table X10: Antimalarial volumes, by outlet type AETDs sold or distributed in the previous week by outlet type and antimalarial type:* 3. Oral artemisinin monotherapy 4. Non-oral artemisinin monotherapy Injectable artesunate Injectable artemether Injectable artemotil 5. Any treatment for severe malaria Public Health Facility # AETD (95% CI) ALL Public / Not ForProfit # AETD (95% CI) Private For-Profit Facility # AETD (95% CI) 0.0 296.2 (148.1, 444.2) 277.4 (129.2, 425.6) 18.8 0.0 773.5 (461.0, 1085.9) 26928.3 0.0 606.3 (306.2, 906.4) 282.3 (130.1, 434.5) 324.0 (43.1, 604.9) 0.0 1159.9 (741.2, 1578.6) 35288.2 22.1 978.2 (680.7, 1275.6) 183.3 721.4 (488.0, 954.8) 73.4 (3.3, 143.6) 1296.5 (930.7, 1662.4) 33591.0 (17583.9, 36272.6) (24494.8, 46081.6) (26918.9, 40263.1) OUTLET TYPE TOTAL*** Registered Pharmacy Unregistered Pharmacy General retailer TOTAL Private ALL Outlets # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) # AETD (95% CI) 0.0 1711.9 46.7 (0.0, 146.0) 1639.6 25.7 (9.4, 41.9) 2316.6 (728.9, 3904.4) 116492.3 (65563.6, 167421.0) 0.0 645.4 (150.9, 1139.8) 218.4 (0.0, 700.5) 422.9 (162.7, 683.1) 4.1 (0.0, 8.4) 918.1 (375.4, 1460.9) 87616.4 (68865.8, 106366.9) 0.0 0.0 0.0 0.0 0.0 2.3 14015.5 22.1 3335.4 (1722.6, 4948.3) 448.4 2783.8 (1429.9, 4137.8) 103.2 (24.2, 182.2) 4533.5 (2291.7, 6775.4) 251715.2 (188246.2, 315184.1) 22.1 3941.7 (2125.8, 5757.6) 730.7 (300.5, 1161.0) 3107.8 (1628.3, 4587.4) 103.2 (24.2, 182.2) 5693.4 (3206.9, 8179.9) 287003.4 (8030.8, 20000.2) (217361.4, 356645.4) * A total of 35645.3 AETDs were reportedly sold or distributed in the previous seven days. See Annex 11 for a description of AETD calculation. At the time of the 2014 ACTwatch outlet survey artemether lumefantrine was Kenya's first line treatment for uncomplicated malaria. A total of 6,651 antimalarials were audited in the census clusters. Of these, 325 audited antimalarials were not included in market share calculations due to incomplete or inconsistent information. Source: ACTwatch Outlet Survey, Kenya, 2014. www.ACTwatch.info Page 156 www.ACTwatch.info Page 157