Symptomenlijst PDF (lang)

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Vitamine B12-tekort Symptomenlijst
Neurologische aanwijzigen en symptomen
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Gecombineerde strengziekte, daaronder verstaan we een aantasting van de achterstrengen van het
ruggenmerg en van de piramide zijstrengen. De aandoening is altijd dubbelzijdig en meestal links en rechts
gelijk. Soms gaat de ziekte gepaard met aangetaste perifere zenuwen.(Polyneuropathie) De ziekte ontstaat
door een B12-tekort. B12 is nodig voor het in stand houden van de myelineschedes. Dit zijn de isolatielagen
om de zenuwbanen. Deze raken beschadigd (soms voor altijd) en dit veroorzaakt het ziektebeeld
paresthesieën. Dat zijn tintelingen, dove en prikkelende gevoelens in de tenen en de voeten en later in de
vingers. Soms verminderen de tintelingen tijdens de slaap, maar na het wakker worden begint het weer en
heeft men het gevoel "dat het lichaam weer tot leven komt".
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Gecombineerde strengziekte door vitamine-B12-deficiëntie: eenvoudige diagnose, effectieve therapie;
J.C.F.Jongen, P.J.Koehler en C.L.Franke Ned Tijdschr Geneeskd 2001 30 juni;145(26)
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Mazure, A.; Bieger, R.; Lambrecht, P.C.L.A.; Wiarda, K.S. ~ Macrocytose, polyneuropathie en
achterstrengstoornis door malabsorptie van eiwitgebonden vitamine B12. Nederlands Tijdschrift voor de
Geneeskunde. 1990; 134 (13): 660 - 662.
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Cerebral Manifestations of vitamin B12 deficiency by J. MacDonald Holmes, M.D., F.R.C.P. Dec. 15, 1956
British Medical Journal.
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Kunze, K.; Leitenmayer, K. ~ Vitamin B12 deficiency and subacute combined degeneration of the spinal
cord.
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Handbook of clinical neurology. Vinken, P.J.; Bruyn W.G. 1977: vol 28 no 6 1977. Elsevier, Amsterdam, pp
141 - 198.
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Blz. 80, 90, 99, 101-103, 154, 192, 200, 204, 205, 222, 226 “Is het Misschien B12-tekort?” Sally M. Pacholok
en Jeffrey M. Stuart.
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Bij ziekenhuisopname op intensive care, is “Vitamine B12” vaak een gemiste invalshoek om de patient nog
betere zorg te kunnen verlenen: “Vitamine B12, de vergeten ‘intensive care-vitamine” (bron: www.ortho.nl)
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Manzanares W, Hardy G. Vitamin B12: the forgotten micronutrient for critical care. Curr Opin Clin Nutr
Metab Care 2010; 13(6):662-8. * Verjaal, A.; Timmermans-van den Bos, A.H.C.C.
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Combined degeneration of the spinal cord due to deficiency of alimentary vitamin B12. Journal of
Neurology, Neurosurgery and Psychiatry. 1967; 30: 464 - 467.
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Subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin B12
deficiency. Cabrerizo-García JL, Sebastián-Royo M, Montes N, Zalba-Etayo B. Sao Paulo Med J.
2012;130(4):259-62.
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Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse.
Fernàndez-Roig S, Lai SC, Murphy MM, Fernandez-Ballart J, Quadros EV. Nutr Metab (Lond). 2012 May
18;9:41.
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Deficiency diseases of the nervous system. Bradley WG, Daroff RB, Fenichel GM, Jankovic J, eds. Bradley:
Neurology in Clinical Practice. 5th ed. Philadelphia, Pa: Butterworth-Heinemann
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Elsevier; 2008:chap 61. Gecombineerde strengziekte door vitamine-B12-deficiëntie: eenvoudige diagnose,
effectieve therapie; J.C.F.Jongen, P.J.Koehler en C.L.Franke Ned Tijdschr Geneeskd 2001 30 juni;145(26)
Hooggevoeligheid, want het gehele zenuwstelsel wordt aangetast door een Vitamine B12-tekort: het zachte
vettige materiaal (myeline) dat onze zenuwen omgeeft en beschermt, wordt beschadigd (demyelinisatie).
Te vergelijken met het strippen van een elektriciteitsdraad. Dat leidt tot allerlei ‘vreemde’ klachten en
‘prikkelingen’, en pijn in armen en benen, etc.) en ook leidt het tot een extreme gevoeligheid voor prikkels,
geluid, licht, stemmingen en ‘energieën’ van andere mensen. Men wordt en is heel lichtgeraakt, kwetsbaar,
schrikachtig. Leidt ook tot snelle grote vermoeidheid en prikkelbaarheid.
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Blz. 45, 65, 70, 86, 88, 100, 102, 105, 154, 191 “Is het Misschien B12-tekort?” - Sally M. Pacholok en Jeffrey
M. Stuart.
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Fine, Edward J. ~ The neurophysiological profile of vitamin B12 deficiency. Muscle and Nerve. 1990; 13:
158 - 164.
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Mayer, R.F. ~ Peripheral nerve function in vitamin B12 deficiency. Archives of Neurology. 1965; 13: 355 362.
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McCombe, P.A.; McLeod, J.G. ~ The peripheral neuropathy of vitamine B12 deficiency. Journal of
Neurological Sciences. 1984; 106: 117 - 126.
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Melson, H.; Kornrad, S. ~ Reversible neuropathy of vitamin B12 deficiency with normal hemoglobin serum
vitamin B12. Lancet. 1977; 1: 803. – 199.
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Abramsky, O. ~ Common and uncommon neurological manifestations as presenting symptoms of vitamin
B12 deficiency. Journal of the American Geriatric Society. 1972; 20: 93 - 96.
Krampen, tintelingen in de voeten en handen en later ook in benen, armen en gezicht. "Het gevoel van
onder stroom te staan"; "mieren lopen in mijn benen – ik word er gek van". Ook een vreemd doof of
verdoofd gevoel in handen en voeten. Uitvalsverschijnselen. Trillende handen.
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Blz. 34, 43, 44, 45, 55, 71, 85, 102, 103, 114, 133, 176, 189, 191 “Is het Misschien B12-tekort?” Sally M.
Pacholok en Jeffrey M. Stuart.
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J Clin Pharmacol 1998; 38:1151-1154. * Abramsky, O. ~ Common and uncommon neurological
manifestations as presenting symptoms of vitamin B12 deficiency. Journal of the American Geriatric Society.
1972; 20: 93 - 96.
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Reversible myelopathy with vitamin B12 deficiency. Senol MG, Sonmez G, Ozdag F, Saracoglu
M.Department of Neurology, GATA Haydarpasa Egitim Hastanesi, Noroloji Servisi, Kadikoy, Istanbul, Turkey.
[email protected]; Singapore Med J. 2008 Nov;49(11):e330-2.
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Masked deficit of vitamin B12 in the patient with heterozygous beta-thalassemia and spastic paraparesis.
Bilic E, Bilic E, Zagar M, Juric S.Department of Pediatric Haematology, University Hospital Centre Zagreb,
Croatia. [email protected]; ta Neurol Belg. 2004 Dec;104(4):173-5.
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Case 30-2004 — A 37-Year-Old Woman with Paresthesias of the Arms and Legs; Peter W. Marks, M.D.,
Ph.D., and Lawrence R. Zukerberg, M.D.; N Engl J Med 2004; 351:1333-1341.
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Case 13-2012 — A 62-Year-Old Man with Paresthesias, Weight Loss, Jaundice, and Anemia; april 2012,
Alberto Puig, M.D., Ph.D., Mari Mino-Kenudson, M.D., and Anand S. Dighe, M.D., Ph.D.;N Engl J Med 2012;
366:1626-1633.
Hyperesthesie, zenuwpijn (neuropathische pijn). Door beschadigde gevoelszenuwen. “Overmatige
gevoeligheid of prikkelbaarheid van de uiteinden van de gevoelszenuwen van (delen van) de huid, die
tintelend, irriterend of pijnlijk kan zijn. De oorzaak kan zowel in de huid (bijvoorbeeld door zenuwontsteking)
als ook centraal gelegen zijn”.
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Nardin RA, Amick AN, Raynor EM. Vitamin B(12) and methylmalonic acid levels in patients presenting with
polyneuropathy. Muscle Nerve 2007; 36(4):532-5.
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Parry T.E. La Presse Medicale 1994;23(3):131-137
Heel vaak moeten plassen, hypertone blaas, incontinentie (plas niet op kunnen houden)
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Blz. 43-45, 50, 52, 55, 88, 184, 186, 202-205, 208 “Is het Misschien B12-tekort?” Sally M. Pacholok en
Jeffrey M. Stuart.
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Rare sensory and autonomic disturbances associated with vitamin B12 deficiency. Puntambekar P, Basha
MM, Zak IT, Madhavan R. J Neurol Sci. 2009 Dec 5;287(1-2):285-7.
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Neuropathic bladder in setting of severe vitamin B12 deficiency: a case report. Campellone JV, Bosley TM,
Malloy TR. J Urol. 1995 Jul;154(1):199-200.
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Neurological signs are common in patients with urodynamically verified "idiopathic" bladder overactivity.
Neurourol Urodyn. 2002;21(1):65-70. Ahlberg J, Edlund C, Wikkelsö C, Rosengren L, Fall M.
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Bladder dysfunction in subacute combined degeneration: a clinical, MRI and urodynamic study. Misra UK,
Kalita J, Kumar G, Kapoor R. J Neurol. 2008 Dec;255(12):1881-8.
Hoofdpijn
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Blz. 44 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Unusual association of Arnold-Chiari malformation and vitamin B12 deficiency. Verma R, Praharaj HN. BMJ
Case Rep. 2012 Jul 9;2012.
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VITAMIN B12 DEFICIENCY & HEADACHES. Article on www.livestrong.com.
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National Institutes of Health; National Heart, Mayo Clinic and Lung and Blood Institute: Pernicous Anemia,
Vitamin B12 Deficiency;by Ed Garcia.Jun 14, 2011.
Migraine
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Lea R, Colson N, [..], Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on
homocysteine-lowering and migraine disability. Pharmacogenet Genomics 2009; 19(6):422-428.
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Role of Magnesium, Coenzyme Q10, Riboflavin, and Vitamin B12 in Migraine Prophylaxis. "Vitamins &
Hormones Volume 69. Vitamins and hormones. Bianchi, A; Salomone, S; Caraci, F; Pizza, V; Bernardini, R;
Damato, C (2004).Vitamins & Hormones 69: 297–312
Restless leg syndrome; rusteloze benen
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B12 & RESTLESS LEGS;National Institutes of Health: Dietary Supplement Fact Sheet - Vitamin B12, 2010.
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Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. Lee KA, Zaffke
ME, Baratte-Beebe K. USA.; J Womens Health Gend Based Med. 2001 May;10(4):335-41.
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Restless legs syndrome in the elderly, P S.T. O'Keeffe, J. Noel and J.N. Lavan, Postgrad Med J (1993) 69, 701
– 703. Ireland.
Ataxie, coördinatie problemen, verminderde positiezin. Onstabiele, ‘onbeholpen’, gang, dronkemansgang,
tot helemaal niet meer kunnen lopen. Scootmobiel-rolstoel-fase is dan aangebroken. En allerlei
aanpassingen (traplift bijv.) aan je woning.
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Blz. 102, 278, 282 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Kishimoto, Y.; Williams, M.; Moser, H.W.; Hignite, B.; Biemann, K. ~ Branched chain and odd-numbered
fatty acids and aldehydes in nervous system of a patient with deranged vitamin B12 metabolism. Journal of
Lipid Research. 1973: 14: 69 - 77.
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Serum vitamin B12 deficiency and hyperhomocystinemia: a reversible cause of acute chorea, cerebellar
ataxia in an adult with cerebral ischemia. Shyambabu C, Sinha S, Taly AB, Vijayan J, Kovoor JM; J Neurol Sci.
2008 Oct 15;273(1-2):152-4. Department of Neurology, NIMHANS, Hosur Road, Bangalore, 560029, India.
Duizeligheid
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Blz. 32, 33, 34, 55, 73, 79, 80, 186, 194, 208, 219, 222, 250, 251, 255, 257, 269 “Is het Misschien B12tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report. Singh
B, Arora S.; Clin Chim Acta. 2010 Dec 14;411(23-24):2104-6. Epub 2010 Aug 22.
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Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR)
gene polymorphism in vitiligo. Yasar A, Gunduz K, Onur E, Calkan M. Dis Markers. 2012;33(2):85-9.
Onverklaarbaar vallen, bot breken, zomaar iets uit de handen laten vallen. Of: geen kracht meer hebben om
deksels van potten af te draaien.
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Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Meyer HE, Grethe ST. Plasma homocysteine, folate, and
vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study. J Bone Miner Res 2007;
22(5):747-56.
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Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental
intake of vitamin B12 and folic acid on fracture incidence; van Wijngaarden JP, Dhonukshe-Rutten RA, van
Schoor NM, van der Velde N, Swart KM, Enneman AW, van Dijk SC, Brouwer-Brolsma EM, Zillikens MC, van
Meurs JB, Brug J, Uitterlinden AG, Lips P, de Groot LC. Department of Human Nutrition, Wageningen
University, P,O, Box 8129 6700 EV Wageningen, the Netherlands. [email protected]; BMC
Geriatr. 2011 Dec 2;11:80.
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Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound
attenuation, and fractures in healthy elderly people. Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P,
Smit JH, van Staveren WA.Human Nutrition, Wageningen University, Wageningen, The Netherlands.
[email protected]; J Bone Miner Res. 2005 Jun;20(6):921-9. Epub 2005 Feb 7.
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Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone
marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Kim GS, Kim CH, Park JY, Lee KU, Park
CS. Division of Endocrinology, Asan Medical Center, Seoul, Korea; Metabolism. 1996 Dec;45(12):1443-6.
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Vitamin B12 deficiency in the elderly. A major contributor to falls. Nelson JM. University of Colorado
Health Sciences Center, Denver, USA. Adv Nurse Pract. 2001 Nov;9(11):39-41.
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Blz. 23, 32, 33, 44, 45, 50, 51, 56, 70, 71, 72, 73, 74, 75, 152, 186, 191, 227, 250, 251, 255, 257, 258 “Is het
Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Osteoporose (afname van botmassa waardoor eerder kans op botbreuk en botslijtage). Verminderde
activiteit van osteoblasten (cellen die nieuw bot aanmaken).
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Blz. 44, 45, 74, 75, 132, 154, 222 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot LC,
Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG. Homocysteine
levels and the risk of osteoporotic fracture. N Engl J Med 2004; 350(20):2033-41.
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Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious
anemia; Mary E. Melton, Michael L. Kochman Department of Internal Medicine, University of Michigan, Ann
Arbor, MI USA.http://dx.doi.org/10.1016/0026-0495(94)90078-7
Oogproblemen, maculadegeneratie.
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Rochtchina E, Wang JJ, Flood VM, Mitchell P. Elevated serum homocysteine, low serum vitamin B12,
folate, and age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol 2007;
143(2):344-6.
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B vitamins may be "silver bullet" for age-related macular degeneration. Daily supplementation with folic
acid plus vitamins B6 and B12 may reduce risk of AMD by 35-40 percent; Duke Med Health News. 2009
May;15(5):8-9.
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Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the
Blue Mountains Eye Study. Rochtchina E, Wang JJ, Flood VM, Mitchell P. Department of Ophthalmology,
Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia; Am J
Ophthalmol. 2007 Feb;143(2):344-6. Epub 2006 Sep 29.
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Christen WG, Glynn RJ, Chew EY, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment
and age-related macular degeneration in women. Arch Intern Med 2009;169:335-41.
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Visual failure caused by vitamin B12 deficiency optic neuropathy; A.J. Larner Int J Clin Pract, October 2004,
58, 10, 977-978
Afname of verlies van gezichtsvermogen
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Blz. 21, 40, 44, 45, 79 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Christen WG, Glynn RJ, [..], Manson JE. Folic acid, pyridoxine, and cyanocobalamin combination treatment
and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular
Study. Arch Intern Med 2009; 169(4):335-41.
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Visual failure caused by vitamin B12 deficiency optic neuropathy; A.J. Larner Int J Clin Pract, October 2004,
58, 10, 977-978.
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Visual failure caused by vitamin B12 deficiency optic neuropathy.Larner AJ. Walton Centre for Neurology
and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK. [email protected];
Aantasting van de oogzenuwen
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Optic atrophy in experimental vitamin B12 deficiency in monkeys. Chester EM, Agam Int J Clin Pract. 2004
Oct;58(10):977-8.anolis DP, Harris JW, Victor M, Hines JD, Kark JA.; Acta Neurol Scand. 1980 Jan;61(1):9-26
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Neuropathology of experimental vitamin B12 deficiency in monkeys. Agamanolis DP, Chester EM, Victor
M, Kark JA, Hines JD, Harris JW.; Neurology. 1976 Oct;26(10):905-14.
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Blz. 101, 221 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Daardoor:
Vreemde oogtrillingen, lichtflitsen, trekken-trillen van de oogleden (vreemde ‘tic’)
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Encephalomyelopathy due to vitamin B12 deficiency with seizures as a predominant symptom.Matsumoto
A, Shiga Y, Shimizu H, Kimura I, Hisanaga K.Department of Neurology, Miyagi National Hospital. Blz. 43, 101,
221 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart. Rinsho Shinkeigaku. 2009
Apr;49(4):179-85.
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Downbeat nystagmus indicates cerebellar or brain-stem lesions in vitamin B12 deficiency. Mayfrank L,
Thoden U.; J Neurol. 1986 Jun;233(3):145-8.
Optische neuropathie (minder goed kleuren zien, wazig zien, moeite met in het donker zien,
gezichtsvelduitval).
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Blz. 101, 102, 212, 221 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Neuropathology of experimental vitamin B12 deficiency in monkeys. Agamanolis DP, Chester EM, Victor
M, Kark JA, Hines JD, Harris JW; Neurology. 1976 Oct;26(10):905-14.
Letsel van de optische oogzenuw, ontsteking, verlamming, infectie of atrofie
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Paralysis of upward gaze as a presenting symptom of vitamin B12 deficiency.Sandyk R. Eur Neurol.
1984;23(3):198-200.
Gehoorproblemen slechter horen, geluid vervormd horen
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Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing loss,
vitamin B-12, and folate in elderly women. American Journal of Clinical Nutrition 1999; 69:564-571
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Gopinath B, Flood VM, [..], Mitchell P. Serum Homocysteine and Folate Concentrations Are Associated
with Prevalent Age-Related Hearing Loss. J Nutr 2010; 140(8):1469-74.
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Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing
loss, vitamin B-12, and folate in elderly women. American Journal of Clinical Nutrition 1999; 69:564-571
Oorsuizingen (sinusitis)
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Vitamine B12 Tekort Oorzaak Oorsuizen? www.optimalegezondheid.com/vitamine-b12-tekort-enoorsuizen
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http://mens-en-gezondheid.infonu.nl/aandoeningen/61690-tinnitus-oorsuizen-oor-geluiden-genezen-enbehandeling.html - http://mens-en-gezondheid.infonu.nl/aandoeningen/64994-vitamine-b12-tekortsymptomen-klachten-oorzaak-voeding.html
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Everdingen, Jannes J.E. van, (hoofdredactie): Het medisch handboek; Kosmos-Z&K Uitgevers,
Utrecht/Antwerpen, vijfde volledig herziene druk 2006.
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Gewrichtspijn, spierpijn, vooral in de heupen maar ook in de polsen en in andere gewrichten. De klachten
lijken voor een deel op die bij Fybromyalgie. De patiënt klaagt veel over een stijf en zwaar gevoel in de
benen. Het lopen is niet stabiel en spierpijn wordt veel erger ervaren als vroeger. ‘Etalagebenen’ (pijn in de
benen bij wandelen). Vaak heeft men ook problemen met fijne motoriek (kleine knoopjes vast maken lukt
niet goed meer en muntjes uit de portemonnee pakken gaat moeilijk)
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The relationship between serum trace elements, vitamin B12, folic acid and clinical parameters in patients
with myofascial pain syndrome. Okumus M, Ceceli E, Tuncay F, Kocaoglu S, Palulu N, Yorgancioglu ZR.
Department of First Physical Medicine and Rehabilitation, Ministry of Health Ankara Training and Research
Hospital, Ankara, Turkey. [email protected].; J Back Musculoskelet Rehabil. 2010;23(4):187-91.
Lage rugpijn
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Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Mauro GL, Martorana
U, Cataldo P, Brancato G, Letizia G. Eur Rev Med Pharmacol Sci. 2000 May-Jun;4(3):53-8.
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Case 46-1969 — Eighty-Year-Old Woman with Back Pain and Abnormal Immunoglobulins, William H.
Baker, and Benjamin Castleman;N Engl J Med 1969; 281:1118-1126.
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Case 12-1990 — A 21-Year-Old Man with Progressive Gastrointestinal Stasis, Hepatomegaly, and a
Neurologic Disorder, Cave D.R. and Compton C.C.N Engl J Med 1990; 322:829-841.
Vreemd gevoel in de voeten hebben: het gevoel van op vilt, op watten of op kussentjes te lopen; het
oppervlaktegevoel is verstoord. Hangende voet
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Recovery of neurologic dysfunction with early intervention of vitamin B12. Ahmed A, Kothari MJ. Penn
State College of Medicine, Hershey Medical Center, Department of Neurology, Hershey, PA 17033, USA; J
Clin Neuromuscul Dis. 2010 Jun;11(4):198-202.
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Loopstoornissen
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Neurologic symptoms as the first manifestation of Addison-Biermer disease.Rzepecki P, Nowosielski J,
Kotowicz J, Betiuk B. V Kliniki Chorób Wewnetrznych IMW CSK WAM, Warszawie; Wiad Lek. 1994 Aug;47(1516):632-4.
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Reversible myelopathy with vitamin B12 deficiency. Senol MG, Sonmez G, Ozdag F, Saracoglu M.
Department of Neurology, GATA Haydarpasa Egitim Hastanesi, Noroloji Servisi, Kadikoy, Istanbul, Turkey.
[email protected]; Singapore Med J. 2008 Nov;49(11):e330-2.
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Blz. 44, 51, 73, 85, 88, 222 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Verdoofd gevoel in ledematen, citaat: “Het oppervlakte gevoel in het onderlichaam en de benen is sterk
verminderd of nagenoeg verdwenen”
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Serial nerve conduction studies in vitamin B12 deficiency-associated polyneuropathy. Huang CR, Chang
WN, Tsai NW, Lu CH. Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center,
Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, Kaohsiung, 833,
Taiwan; Neurol Sci. 2011 Feb;32(1):183-6. Epub 2010 Oct 2.
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Blz. 70, 77, 84, 88, 102, 103, 105, 114, 133, 171, 176, 178, 184, 188, 191 “Is het Misschien B12-tekort?”
Sally M. Pacholok en Jeffrey M. Stuart.
Verzwakking in benen, romp of ander deel van lichaam (ook zelfs van de stem)
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A case of subacute combined degeneration with normal serum vitamin B12 level.Nagaishi A, Takashima H,
Fukuda Y, Kuroda Y.Department of Internal Medicine, Sasebo City General Hospital.; Rinsho Shinkeigaku.
2003 Sep;43(9):552-5.
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A case of vitamin B12 deficiency with broad neurologic disorders and canities. Katsuoka H, Watanabe C,
Mimori Y, Nakamura S. Third Department of Internal Medicine, Hiroshima University School of Medicine,
Japan; No To Shinkei. 1997 Mar;49(3):283-6.
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Vitamin B12 deficiency: an unusual cause of vocal fold palsy.Green R, Kara N, Cocks H. UK.
[email protected]; J Laryngol Otol. 2011 Dec;125(12):1309-11. Epub 2011 Jul 27.
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Blz. 32-34, 42-44, 47, 71, 72, 79-81, 83, 85, 90, 126, 137, 171, 186, 193, 211, 217, 218, 222, 228, 234, 235,
244, 250, 251, 255, 263, 281, 287, 291 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Verlamming
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Encephalomyelopathy due to vitamin B12 deficiency with seizures as a predominant symptom.
Matsumoto A, Shiga Y, Shimizu H, Kimura I, Hisanaga K. Department of Neurology, Miyagi National Hospital;
Rinsho Shinkeigaku. 2009 Apr;49(4):179-85.
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Paralysis and pernicious anemia in a young woman.Matrana MR, Gauthier C, Lafaye KM. Internal Medicine
Residency Program, Ochsner Clinic Foundation, New Orleans, LA, USA; J La State Med Soc. 2009 JulAug;161(4):228-32.
100
Recurrent facial palsy, primary Gougerot-Sjögren's syndrome and vitamin B12 deficiency.Rousso E, Noel E,
Brogard JM, Blicklé JF, Andrès E. Service de médecine interne, diabète et maladies métaboliques de la
Clinique médicale B, Hôpitaux universitaires de Strasbourg; Presse Med. 2005 Jan 29;34(2 Pt 1):107-8.
101
Difficulties in the diagnosis in the case of subacute paraplegia in a woman with Addison-Biermer disease.
Szupień E, Ositek B, Pniewski J. Klinika Neurologii, Centralny Szpital Kliniczny MSWiA w Warszawie, Warsaw,
Poland; Neurol Neurochir Pol. 2004 Sep-Oct;38(5):431-6.
102
Neurologic symptoms as the first manifestation of Addison-Biermer disease.Rzepecki P, Nowosielski J,
Kotowicz J, Betiuk B. V Kliniki Chorób Wewnetrznych IMW CSK WAM, Warszawie; Wiad Lek. 1994 Aug;47(1516):632-4.
103
Inborn error of vitamin B12 metabolism: a treatable cause of childhood dementia/paralysis. Al Essa M,
Sakati NA, Dabbagh O, Joshi S, Al Jishi EA, Rashed MS, Powe JE, Ozand PT. Department of Pediatrics, King
Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; J Child Neurol. 1998 May;13(5):239-43.
104
Paralysis and pernicious anemia in a young woman.Matrana MR, Gauthier C, Lafaye KM. Internal
Medicine Residency Program, Ochsner Clinic Foundation, New Orleans, LA, USA; J La State Med Soc. 2009
Jul-Aug;161(4):228-32
105
Blz. 25, 40, 43, 44, 72, 79, 81, 109, 171, 190, 257 “Is het Misschien B12-tekort?” Sally M. Pacholok en
Jeffrey M. Stuart.
Ouderdomsklachten, als vergeetachtigheid, moeheid, depressie, trillende ledematen, hartritmestoornissen,
evenwichtsproblemen, vallen (en bot breken), osteoporose, slecht zien en horen, kunnen in veel gevallen
(mede) te maken hebben met het hebben van een chronisch langdurig tekort aan Vitamine B12.
106
Walker JG, Batterham PJ, [..], Christensen H. Oral folic acid and vitamin B-12 supplementation to prevent
cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project:
a randomized controlled trial. Am J Clin Nutr 2012; 95(1):194-203.
107
Skarupski KA, Tangney C, [..], Morris MC. Longitudinal association of vitamin B-6, folate, and vitamin B-12
with depressive symptoms among older adults over time. Am J Clin Nutr 2010; 92(2):330-5
108
Tangney CC, Aggarwal NT, [..], Morris MC. Vitamin B12, cognition, and brain MRI measures: A crosssectional examination. Neurology 2011; 77(13):1276-82. -7.
109
Dimopoulos N, Piperi C, Salonicioti A, Psarra V, Gazi F, Papadimitriou A, Lea RW, Kalofoutis A. Correlation
of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population. Clin
Biochem 2007; 40(9-10):604-8
110
Louwman MWJ et al. Signs of impaired cognitive function in adolescents with marginal cobalamin status.
Am J Clin Nutr 2000;72:762-769.
111
Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing
loss, vitamin B-12, and folate in elderly women. American Journal of Clinical Nutrition 1999; 69:564-571.
© VitamineB12nu.nl
112
Stott D.J. et al. Prevalence and haemopoietic effects of low serum vitamin B12 levels in geriatric medical
patients. British Journal of Nutrition 1997;78:57-63.
113
Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects;
Dieneke ZB van Asselt, Lisette CPGM de Groot, Wija A van Staveren, Henk J Blom, Ron A Wevers, Izak
Biemond, and Willibrord HL Hoefnagels Am J Clin Nutr 1998;68:328-34.
114
Functional vitamin B12 deficiency and Alzheimer disease A. McCaddon, MRCGP; B. Regland, MD, PhD; P.
Hudson, MSc; and G. Davies, MSc Neurology 2002;58:1395-1399;
115
Clinical significance of low cobalamin levels in older hospital patient; Dieneke Z. van Asselt , Henk J. Blom ,
Richard Zuiderent , Ron A. Wevers, Cornelis Jakobs , Wim J. van den Broek , Cornelis B. Lamers , Frans H.
Corstens , Willibrord H. Hoefnagels The Netherlands Journal of Medicine 2000;57:41-49;
116
Joosten, E.; e.a. ~ Vitamin B12 (cobalamine) gebrek bij bejaarden. Nederlands Tijdschrift voor de
Geneeskunde. 1990; 134 (13): 652 - 656.
117
McRea, Thomas D.; Freedman Michael L. ~ Why vitamin B12 deficiency should be managed aggressively.
Geriatrics. November 1989; 44 (2): 70 - 79.
118
Schulman, R. ~ A survey of vitamin B12 deficiency in an elderly psychiatric population. British Journal of
Psychiatry. 1967a; 113: 241 - 251.
119
Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults.
Leishear K, Boudreau RM, Studenski SA, Ferrucci L, Rosano C, de Rekeneire N, Houston DK, Kritchevsky SB,
Schwartz AV, Vinik AI, Hogervorst E, Yaffe K, Harris TB, Newman AB, Strotmeyer ES; Health, Aging and Body
Composition Study. J Am Geriatr Soc. 2012 Jun;60(6):1057-63.
120
[Vitamin B12 and folic acid deficiency in the population over 65 years: A descriptive study.]VazquezPedrazuela MD, Canton-Alvarez MB, de la Fuente-Hontañon MD, Soloaga-Morales A, Collazos-Del Castillo
JM, Sertal-Parcero R. Rev Esp Geriatr Gerontol. 2012 May 28.
121
Vitamin B12 deficiency in Australian residential aged care facilities. Mirkazemi C, Peterson GM, Tenni PC,
Jackson SL. J Nutr Health Aging. 2012 Mar;16(3):277-80.
122
The neuropsychiatry of vitamin B12 deficiency in elderly patients. Lachner C, Steinle NI, Regenold WT. J
Neuropsychiatry Clin Neurosci. 2012 Dec 1;24(1):5-15. Review.
123
Vitamin B12 supplementation improves heart rate variability in healthy elderly Indian subjects. Sucharita
S, Thomas T, Antony B, Vaz M. Auton Neurosci. 2012 May 21;168(1-2):66-71.
124
An investigation of vitamin B12 deficiency in elderly inpatients in neurology department. Wang YH, Yan F,
Zhang WB, Ye G, Zheng YY, Zhang XH, Shao FY.Department of Neurology, Shanghai Punan hospital, Shanghai
200125, China. [email protected]; Neurosci Bull. 2009 Aug;25(4):209-15.
125
Garcia, Angela, et al. Is low-dose oral cobalamin enough to normalize cobalamin function in older people?
Journal of the American Geriatrics Society, Vol. 50, August 2002, pp. 1401-04.
126
Slowly progressive type 1 diabetes mellitus associated with vitiligo vulgaris, chronic thyroiditis, and
pernicious anemia. Suzuki C, Hirai Y, Terui K, Kohsaka A, Akagi T, Suda T. Department of Endocrinology,
Aomori Prefectural Central Hospital, Aomori.; Intern Med. 2004 Dec;43(12):1183-5.
127
Relationship of vitamin B12 deficiency with incontinence in older people. Rana S, D'Amico F, Merenstein
JH. J Am Geriatr Soc 1998;46:931-2.
128
Studies on vitamin B12 status in the elderly--prophylactic and therapeutic consequences.Loew D,
Wanitschke R, Schroedter A.Institute of Clinical Pharmacology, Johann Wolfgang Goethe University,
Frankfurt, Germany; Int J Vitam Nutr Res. 1999 May;69(3):228-33.
129
Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline. Feng L.Folic acid and
vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with
depressive symptoms--the Beyond Ageing Project: a randomized controlled trial. [Am J Clin Nutr. 2012; Am J
Clin Nutr. 2012 May;95(5):1289-90
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Maag(zuur)klachten
130
Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP. Do acid-lowering agents affect
vitamin B12 status in older adults? J Am Med Dir Assoc 2008; 9(3):162-7.
131
Morphological features and secretory gastric function in patients with chronic gastritis against the
background of B12 deficiency anemia. Vorob'ev SA; Eksp Klin Gastroenterol. 2006;(4):11-6, 114.
132
Cobalamin (Vitamin B12) deficiency: is it a problem for our aging population and is the problem
compounded by drugs that inhibit gastric acid secretion? Kapadia C.; J Clin Gastroenterol. 2000 Jan;30(1):4-6.
Vroegtijdige veroudering
133
Tangney CC, Aggarwal NT, [..], Morris MC. Vitamin B12, cognition, and brain MRI measures: A crosssectional examination. Neurology 2011; 77(13):1276-82.
134
Walker JG, Batterham PJ, [..], Christensen H. Oral folic acid and vitamin B-12 supplementation to prevent
cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project:
a randomized controlled trial. Am J Clin Nutr 2012; 95(1):194-203.
135
van Asselt DZ, Pasman JW, van Lier HJ, Vingerhoets DM, Poels PJ, Kuin Y, Blom HJ, Hoefnagels WH.
Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons.
J Gerontol A Biol Sci Med Sci 2001; 56(12):M775-9.
136
Herzlich BC et al. Relationship among homocyst(e)ine, vitamin B-12 and cardiac disease in the elderly:
association between vitamine B12 deficiency and decreased left ventricular ejection fraction. Journal of
Nutrition 1996;126:1249S-1253.
137
Developmental regression as an early manifestation of vitamin B12 deficiency. Sadowitz, P.D.; e.a. ~
Clinical Pediatrics. 1986; 25: 369 – 371; J Hum Lact December 1, 1986 2: 129-132
138
Geriatrics. 1989 Nov;44(11):70-3, 76, 79.
139
Why vitamin B12 deficiency should be managed aggressively. McRae TD, Freedman ML. Department of
Internal Medicine, New York University School of Medicine; Geriatrics. 1989 Nov;44(11):70-3, 76, 79.
140
Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Vogiatzoglou A, Refsum
H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD. Department of Physiology, Anatomy
and Genetics, University of Oxford, Le Gros Clark Building, South Parks Rd., Oxford OX1 3QX, UK.
[email protected]; Neurology. 2008 Sep 9;71(11):826-32.
141
Low vitamin B-12 status and risk of cognitive decline in older adults. Clarke R, Birks J, Nexo E, Ueland PM,
Schneede J, Scott J, Molloy A, Evans JG. University of Oxford, . [email protected]; Am J Clin Nutr.
2007 Nov;86(5):1384-91.
142
Normalization of low vitamin B12 serum levels in older people by oral treatment.Verhaeverbeke I, Mets T,
Mulkens K, Vandewoude M.; J Am Geriatr Soc. 1997 Jan;45(1):124-5.
143
Early normalization of low vitamin B12 levels by oral cobalamin therapy in three older patients with
pernicious anemia; Kaltenbach G, Noblet-Dick M, Barnier-Figue G, Berthel M, Kuntzmann F, Andres E.; J Am
Geriatr Soc. 2002 Nov;50(11):1914-5.
144
Why vitamin B12 deficiency should be managed aggressively. McRae TD, Freedman ML. New York
University School of Medicine;Epub 2008 Nov 5. Geriatrics. 1989 Nov;44(11):70-3, 76, 79.
333
Blz.164 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Alzheimer (ook vroegtijdige), vitamine B12, dat dagelijks wordt ingenomen, verlaagt volgens de
onderzoeksresultaten die gepubliceerd werden in de 'American Journal of Clinical Nutrition', het risico op
beginnende dementie en de ziekte van Alzheimer met 30 procent. De wetenschappers volgden 1648
senioren in de leeftijdscategorie tussen 65 en 90 jaar gedurende een periode van 10 jaar. Vitamine B12 heeft
de eigenschap om een te hoog en schadelijk homocysteïneniveau drastisch te verlagen. Daardoor ontstaat er
minder cardiovasculaire-schade en minder hersenschade naarmate de leeftijd vordert
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Robert Clarke, J. Birks, E. Nexo, P.M. Ueland, J. Schneede, J. Scott, A. Molloy and J. Grimley Evans. Low
vitamin B-12 status and risk of cognitive decline in older adults November 2007, Volume 86, Number 5,
Pages 1384-1391 - American Journal of Clinical Nutrition
146
Blz. 17, 21, 25, 41, 43, 47, 50, 60, 61, 63-67, 69, 77, 105, 132, 212, 226, 255 “Is het Misschien B12-tekort?”
147
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive
impairment: a randomized controlled trial. de Jager CA, Oulhaj A, [..], Smith AD. Int J Geriatr Psychiatry 2011
Jul 21.
148
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study;
Hooshmand B, Solomon A, [..], Kivipelto M.; Neurology 2010; 75(16):1408-14.
149
Vitamin B12 and folate in relation to the development of Alzheimer’s disease; H-X. Wang, Å. Wahlin, H.
Basun, J. Fastbom, B. Winblad, and L. Fratiglioni; Neurology May 8, 2001 56:1188-1194.
150
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with
Alzheimer's disease? Joosten E et al. Journal of Gerontology: Medical Sciences 1997;52A:M76-M79.
151
Low serum vitamin B12 in Alzheimer-type dementia. Cole, M.; e.a. ~ Age Ageing. 1984; 13: 101 - 105.
152
Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Wang HX, Wahlin A,
Basun H, Fastbom J, Winblad B, Fratiglioni L.Stockholm. [email protected]; Neurology. 2001 May
8;56(9):1188-94.
153
Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective
study. Eur J Neurol. 2009 Jul;16(7):808-13. Epub 2009 Apr 21. Kivipelto M, Annerbo S, Hultdin J, Bäckman L,
Viitanen M, Fratiglioni L, Lökk J.
154
A Specific Multi-Nutrient Diet Reduces Alzheimer-Like Pathology in Young Adult AβPPswe/PS1dE9 Mice.
Broersen LM, Kuipers AA, Balvers M, van Wijk N, Savelkoul PJ, de Wilde MC, van der Beek EM, Sijben JW,
Hageman RJ, Kamphuis PJ, Kiliaan AJ.; Wageningen, Holland; J Alzheimers Dis. 2012 Aug 22.
155
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and
healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.Faux
NG, Ellis KA, Porter L, Fowler CJ, Laws SM, Martins RN, Pertile KK, Rembach A, Rowe CC, Rumble RL, Szoeke
C, Taddei K, Taddei T, Trounson BO, Villemagne VL, Ward V, Ames D, Masters CL, Bush AI; Australia; J
Alzheimers Dis. 2011;27(4):909-22.
327
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau Hyperphosphorylation and
memory deficits in aged rats;Wei W, Liu YH, Zhang CE, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu
GP. China.; J Alzheimers Dis. 2011;27(3):639-50.
Parkinson (ook vroegtijdige) NB: Het gebruik van het bij Parkinson veelgebruikte medicijn Levodepa, leidt tot
een Vitamine B12-tekort.
156
Neurology [2011] Nov 2 (Y.A.Rajabally, J.Martey)
157
Blz. 17, 21, 25, 59, 69, 76, 79, 81, 82, 96 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M.
Stuart.
158
Dos Santos EF, Busanello EN, [..], Wajner M. Evidence that folic acid deficiency is a major determinant of
hyperhomocysteinemia in Parkinson's disease. Metab Brain Dis 2009; 24(2):257-69.
159
Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a casecontrol study in Japan.Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y,
Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson's
Disease Study Group; Br J Nutr. 2010 Sep;104(5):757-64. Epub 2010 Mar 26.
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Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the
transcobalamin-oleosin chimera in substantia nigra. Orozco-Barrios CE, Battaglia-Hsu SF, Arango-Rodriguez
ML, Ayala-Davila J, Chery C, Alberto JM, Schroeder H, Daval JL, Martinez-Fong D, Gueant JL. Department of
Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto
Politécnico Nacional (CINVESTAV), Mexico City, Mexico; PLoS One. 2009 Dec 21;4(12):e8268.
161
Is the deficiency of vitamin B12 related to oxidative stress and neurotoxicity in Parkinson's patients?
Qureshi GA, Qureshi AA, Devrajani BR, Chippa MA, Syed SA.Medical Research Centre, Liaquat University of
Medical & Health Sciences, Jamshoro, Pakistan. [email protected]; CNS Neurol Disord Drug Targets.
2008. Feb;7(1):20-7.
162
Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to
clinical manifestations, mood and cognition.Triantafyllou NI, Nikolaou C, Boufidou F, Angelopoulos E,
Rentzos M, Kararizou E, Evangelopoulos ME, Vassilopoulos D. Department of Neurology, Aeginition Hospital,
Athens University Medical School, Athens, Greece; Parkinsonism Relat Disord. 2008;14(4):321-5. Epub 2007
Dec 4.
163
Homocysteine and Parkinson's disease: a dangerous liaison? Martignoni E, Tassorelli C, Nappi G, Zangaglia
R, Pacchetti C, Blandini F. IRCCS S. Maugeri Foundation, Scientific Institute of Veruno, Via per Revislate 13,
28010 Veruno (NO), Italy. [email protected]; J Neurol Sci. 2007 Jun 15;257(1-2):31-7. Epub 2007
Mar 1.
164
Case of acute parkinsonism of the infant treated with vitamin B12. PRIOLISI A.; Pediatria (Napoli). 1959
Mar-Apr;67(2):325-33.
165
Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the
transcobalamin-oleosin chimera in substantia nigra.Orozco-Barrios CE, Battaglia-Hsu SF, Arango-Rodriguez
ML, Ayala-Davila J, Chery C, Alberto JM, Schroeder H, Daval JL, Martinez-Fong D, Gueant JL. PLoS One. 2009
Dec 21;4(12):e8268.
Hart en vaatproblemen
Een tekort aan vitamine B12 lijdt tot een verhoogde homocysteïnewaarde. Een verhoogde homocysteïnewaarde is
een grote risicofactor voor hart- en vaatziekten (te vergelijken met een hoog cholesterolgehalte).
• Pernicieuze anemie (kwaadaardige bloedarmoede)
Wikipedia: “Pernicieuze anemie is een vorm van macrocytaire anemie. Dat wil zeggen dat de rode
bloedcellen vergroot zijn. Er ontbreekt een bouwsteen voor hemoglobine, namelijk vitamine B12. De
opname van vitamine B12 gebeurt in het laatste deel van de dunne darm. Hiervoor moet het eerst
gekoppeld worden aan het intrinsic factor dat door de maagwand wordt geproduceerd. Door een autoimmuunreactie tegen de pariëtale cellen van de maag is de productie van intrinsic factor verstoord en kan
vitamine B12 niet worden opgenomen in het lichaam.“
166
Wikipedia: http://nl.wikipedia.org/wiki/Pernicieuze_anemie
167
Blz. 58, 85-86, 137, 152, 192, 209, 217, 221, 226, 282, 284 “Is het Misschien B12-tekort?” Sally M.
168
Restoration of decreased suppressor cells by vitamin B12 therapy in a patient with pernicious anemia.
Kubota K, Arai T, Tamura J, Shirakura T, Morita T.; Am J Hematol. 1987 Feb;24(2):221-3.
169
Stopeck, A. Links Between Helicobacter pylori Infection, Cobalamin Deficiency, and Pernicious Anemia.
Arch Intern Med. 2000; 160:1349-1353
170
Lebdetter, R.B.; Del Pozo, L. ~ Severe megaloblastic anemia due to nutritional vitamin B12 deficiency. Acta
Haematologica. 1969; 42: 247 - 253.
171
Lederle, Frank A. ~ Oral cobalamine for pernicious anemia: medicine's best kept secret. JAMA. 1991; 265
(1): 94 – 5.
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Linnell, J.C.; e.a. ~ Tissue distribution of coenzyme and other forms of vitamin B12 in control subjects and
patients with pernicious anaemia. Clinical Science and Molecular Medicine. 1974b; 46: 163 - 172.
173
Berlin, Ragnar; Berlin, Hans; Brante, Gunnar ~ Oral treatment of pernicious anemia with high doses of
vitamin B12 without intrinsic factor. Acta Medica Scandinavica. 1968; 184: 247 - 258.
174
Wokes, Frank ~ Anemia and vitamin B12 deficiency. Proceedings of the Nutrition Society. 1956; 15: 134 141.
175
Woltman H.W. ~ The mental changes associated with pernicious anemia. American Journal of Medicine.
1924; 80: 435 - 449.
176
Woltman H.W. ~ The nervous symptoms in pernicious anemia: an analysis of one hundred and fifty cases.
American Journal of Medicine. 1919; 157: 400 - 409.
177
Berlin, Ragnar; Berlin, Hans; Brante, Gunnar; Pilbrant, Ake ~ Vitamin B12 stores during oral treatment and
parenteral treatment of pernicious anemia. Acta Medica Scandinavica. 1978; 204: 81 - 84.
178
Pollycove, M.; e.a. ~ Pernicious anemia due to dietary deficiency of vitamin B12. New England Journal of
Medicine. 1956; 255: 164 - 169.
179
Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency
anemia.Takasaki Y, Moriuchi Y, Tsushima H, Ikeda E, Koura S, Taguchi J, Fukushima T, Tomonaga M, Ikeda
S.Japan; Rinsho Ketsueki. 2002 Mar;43(3):165-9.
180
Biermer's disease and auto-immune haemolytic anaemia. Nafil H, Tazi I, Mahmal L. Ann Biol Clin (Paris).
2012 Aug 1;70(4):480-482.
181
Clinical spectrum and diagnosis of cobalamin deficiency. Stabler SP, Allen RH, Savage DG, Lindenbaum J.
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262; Blood. 1990 Sep
1;76(5):871-81.
328
Reisner, Edward H. ~ Oral treatment of pernicious anemia with vitamin B12 without intrinsic factor. New
England Journal of Medicine. 1955; 253: 502 - 506.
Vergrote milt of lever
182
Severe vitamin B12 deficiency in an exclusively breastfed 5-month-old Italian infant born to a mother
receiving multivitamin supplementation during pregnancy. Guez S, Chiarelli G, Menni F, Salera S, Principi N,
Esposito S. Pediatric Clinic 1, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale
Maggiore Policlinico, Milano, Italy. [email protected]; BMC Pediatr. 2012 Jun 24;12:85. doi:
10.1186/1471-2431-12-85.
183
Severe vitamin B12 deficiency resulting in pancytopenia, splenomegaly and leukoerythroblastosis.
Halfdanarson TR, Walker JA, Litzow MR, Hanson CA.Department of Internal Medicine, Division of
Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA. [email protected];
Eur J Haematol. 2008 May;80(5):448-51. Epub 2008 Jan 23.
334
Schildklierafwijkingen/ziekten
184
Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease.Ness, Abramof
R, Nabriski DA, Braverman LE, Shilo L, Weiss E, Reshef T, Shapiro MS, Shenkman L.; Am J Med Sci 2006;
332(3):119-22.
185
The role of vitamins in the prevention and treatment of thyroid disorders. Sworczak K, Wiśniewski P.
Poland. [email protected]; Endokrynol Pol. 2011;62(4):340-4.Vitamin B12 deficiency common in
primary hypothyroidism. Jabbar A, Yawar A, Waseem S, Islam N, Ul Haque N, Zuberi L, Khan A, Akhter J.;
Pakistan; J Pak Med Assoc. 2008 May;58(5):258-61.
186
Vitamin B12 deficiency neurological syndromes: correlation of clinical, MRI and cognitive evoked
potential. Kalita J, Misra UK., India. [email protected]; J Neurol. 2008 Mar;255(3):353-9. Epub 2008 Mar
20.
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Prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid
disease.Perros P, Singh RK, Ludlam CA, Frier BM.; UK.; [email protected]; Diabet Med. 2000 Oct;17(10):74951.
188
Anemia in hypothyroidism.Antonijević N, Nesović M, Trbojević B, Milosević R.; Croatian; Med Pregl. 1999
Mar-May;52(3-5):136-40.
329
Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease,Ness-Abramof
R, Nabriski DA, Braverman LE, Shilo L, Weiss E, Reshef T, Shapiro MS, Shenkman L., Israel; [email protected];
Am J Med Sci. 2006 Sep;332(3):119-22.
542
American Journal of the Medical Sciences. 332(3):119-122, September 2006, Ness-Abramof, Rosane MD;
Nabriski, Dan A. MD; Braverman, Lewis E. MD; Shilo, Lotan MD; Weiss, Eliahu MSc; Reshef, Tamar MSc;
Shapiro, Menachem S. MD; Shenkman, Louis MD.
543
Dissociation of the intrinsic factor--vitamin B12 complex by bile: contributing factor to B12 malabsorption
in pancreatic insufficiency. Cotter R, Rothenberg SP, Weiss JP.; Scand J Gastroenterol. 1979;14(5):545-50.
BloedafwijkingenVergrote rode bloedlichaampjes (macrocyten). Gehypersegmenteerde neutrofiele
granulocyten. Ovalocytose.
189
190
Al-Momen AKJ. Diminished vitamin B12 levels in patients with severe sickle cell disease. Journal of
Internal Medicine 1995;237:551-555.
191
Subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin B12
deficiency. Cabrerizo-García JL, Sebastián-Royo M, Montes N, Zalba-Etayo B.Internal Medicine Service,
Defense General Hospital, Zaragoza, Spain; Sao Paulo Med J. 2012;130(4):259-62.
192
Vitamin B12 deficiency--a major cause of megaloblastic anaemia in patients attending a tertiary care
hospital. Iqbal SP, Kakepoto GN, Iqbal SP.Department of Pathology and Microbiology, Aga Khan University,
Karachi, Pakistan; J Ayub Med Coll Abbottabad. 2009 Jul-Sep;21(3):92-4.
193
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. Savage D, Gangaidzo
I, Lindenbaum J, Kiire C, Mukiibi JM, Moyo A, Gwanzura C, Mudenge B, Bennie A, Sitima J, et al.Department
of Haematology, University of Zimbabwe, Harare; Br J Haematol. 1994 Apr;86(4):844-50.
Macrocytose (vergrote rode bloedlichaampjes)
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262, 268, 269, 272, 277, 279, 282 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis;
Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett ER, Podell ER, et al. N Eng J Med 1988;318:1720-8.
Bloedproppen
196
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Bleie O, Strand E, [..], Nygård OK. Coronary blood flow in patients with stable coronary artery disease
treated long term with folic acid and vitamin B12. Coron Artery Dis 2011; 22(4):270-8
198
Omar S, Ghorbel IB, Feki H, Souissi M, Feki M, Houman H, Kaabachi N. Hyperhomocysteinemia is
associated with deep venous thrombosis of the lower extremities in Tunisian patients. Clin Biochem 2007;
40(1-2):41-5
Hart- en vaatproblemen
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Quinlivan EP, McPartlin J, McNulty H, Ward M, Strain JJ, Weir DG, Scott JM. Importance of both folic acid
and vitamin B12 in reduction of risk of vascular disease. Lancet 2002; 359:227?228.
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Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and
vitamin B12. Bleie Ø, Strand E, Ueland PM, Vollset SE, Refsum H, Igland J, Nordrehaug JE, Nygård OK.
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. [email protected]; Coron Artery Dis. 2011 Jun;22(4):270-8.
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Gastric status and vitamin B12 levels in cardiovascular patients. van Oijen MG, Sipponen P, Laheij RJ,
Verheugt FW, Jansen JB. Department of Medicine, Division of Gastroenterology, Radboud University
Nijmegen Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. [email protected];
Dig Dis Sci. 2007 Sep;52(9):2186-9. Epub 2007 Apr 11.
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Homocysteine, vitamin B12 and folate levels in premature coronary artery disease. Sadeghian S, Fallahi F,
Salarifar M, Davoodi G, Mahmoodian M, Fallah N, Darvish S, Karimi A; Tehran Heart Center. Research
Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
[email protected]; BMC Cardiovasc Disord. 2006 Sep 26;6:38.
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Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations
which initiate atherosclerosis? Newman PE. Med Hypotheses. 1999 Nov;53(5):421-4.
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Van Guelpen B, Hultdin J, Johansson I, et al. Folate, vitamin B12, and risk of ischemic and hemorrhagic
stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake. Stroke
2005;36:1426-31.
Diep veneuze trombose (bloedprop in arm of been)
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Increased p-homocysteine--a risk factor for thrombosis. Jensen OK, Ingerslev J. Center for haemofili og
trombose, klinisk immunologisk afdeling, Arhus Universitetshospital, Skejby Sygehus; Ugeskr Laeger. 1998 Jul
20;160(30):4405-10.
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Vitamin B12 deficiency causing hyperhomocysteinaemia and cerebral venous sinus thrombosis. Whyte
AF, Jones DL, Dreyer MD; Intern Med J. 2012 May;42(5):601-3.
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Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study. Remacha AF,
Souto JC, Piñana JL, Sardà MP, Queraltó JM, Martí-Fabregas J, García-Moll X, Férnandez C, Rodriguez A,
Cuesta J. Department of Hematology, Complejo Hospitalario Toledo, Hospital Virgen de la Salud, Avenida
Barber 30, 45004, Toledo, Spain. [email protected]; Int J Hematol. 2011 Apr;93(4):458-64. Epub
2011 Apr 8.
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Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity.
Brazzelli V, Grasso V, Fornara L, Moggio E, Gamba G, Villani S, Borroni G. Department of Human and
Hereditary Pathology, Institute of Dermatology, University of Pavia and Foundation IRCCS Policlinico San
Matteo, Pavia, Italy. [email protected]; Int J Immunopathol Pharmacol. 2010 Jul-Sep;23(3):911-6.
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Verhoogd homocysteïne-niveau, als gevolg van Vitamine B12-tekort. Homocysteine is een potentieel
gevaarlijk aminozuur. Wanneer homocysteïne zich ophoopt in het bloed, neemt het risico op coronaire
hartziekte, beroerten en bloedproppen sterk toe. En een hoog homocysteïne kan de bloedvaten
beschadigen. En ook aderverkalking mede veroorzaken (atherosclerose) met een versneld risico op
hartinfarcten en beroertes (in relatief korte tijd ontstaan). Ook kan homocysteïne het cholesterol in een
schadelijke vorm veranderen, waardoor bloedvaten sneller beschadigd raken. Het kan ook bijdragen aan de
verstoring van de werking van endotheelcellen (binnenbekleding van de bloedvaten). Bij zwangerschap kan
een verhoogd homocysteïnegehalte van het bloed ook voor een toegenomen vatbaarheid voor preeclampsie, een potentieel gevaarlijke complicatie van de zwangerschap, zorgen
210
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Jeffrey M. Stuart.
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Koyama K, Usami T, Takeuchi O, Morozumi K, Kimura G. Efficacy of methylcobalamin on lowering total
homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid
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Manzanares W, Hardy G. Vitamin B12: the forgotten micronutrient for critical care. Curr Opin Clin Nutr
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Homocysteine, folate and vitamin b12 in patients with coronary heart disease. Genser D, Prachar H,
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Hyperhomocysteinaemia and vitamin B12 deficiency: the long-term effects in cardiovascular disease. van
Oijen MG, Vlemmix F, Laheij RJ, Paloheimo L, Jansen JB, Verheugt FW. Department of Gastroenterology,
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. [email protected];
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Homocysteine and coronary heart disease. Clarke R, Lewington S. Clinical Trial Service Unit and
Epidemiological Studies Unit, Radcliffe Infirmary, University of Oxford, Oxford, United Kingdom.
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Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology. de la Calle M, Usandizaga R,
Sancha M, Magdaleno F, Herranz A, Cabrillo E.Department of Obstetrics and Gynaecology, Hospital La Paz,
Paseo de la Castellana n 261, 28046 Madrid, Spain; Eur J Obstet Gynecol Reprod Biol. 2003 Apr
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Update on Cobalamin, Folate, and Homocysteine; Ralph Carmel, Ralph Green, David S. Rosenblatt, and
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Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal
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Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and
chronic fatigue syndrome Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Scand
J Rheumatol. 1997;26(4):301-7.
Duizeligheid, draaierigheid, evenwichtsproblemen (in combinatie met hart/vaatziekten)
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Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report. Singh
B, Arora S.GB Pant Hospital, Room 418, Dept of Biochemistry, Academic Block, Jawahar Lal Nehru Marg, New
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Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12
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Orthostatic hypotension revealing vitamin B12 deficiency. Girard P, Lebrun C, Peyrade F, Brunetto JL,
Chatel M. Service de Neurologie, Hôpital Pasteur, Nice; Rev Neurol (Paris). 1998 May;154(4):342-4.
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Ultrastructure of the H. pylori microbe in individuals having macrocytosis and B12 deficiency.
Khubchandani SR, Kulkarni S, Teckchandani S, Chitale A.Jaslok Hospital & Research Center, Deshmukh Marg,
Mumbai, India. [email protected]; Ultrastruct Pathol. 2011 Oct;35(5):204-8. Epub 2011 Aug
25.
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Benauwdheid en pijn op de borst; angineuze pijnen
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New observation of pernicious anemia with syndrome of intermittent claudication and effort angina
disappearing after treatment of the anemia, CAHEN P, BRUN F, BLANC J.; Lyon Med. 1954 Jun 6;86(23):4848.
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Coronaire hartziekte
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Herzlich BC et al. Relationship among homocyst(e)ine, vitamin B-12 and cardiac disease in the elderly:
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Bleie O, Strand E, [..], Nygård OK. Coronary blood flow in patients with stable coronary artery disease
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Verhoogd risico op Cardiovasculaire aandoeningen, arteriosclerose en arterieel en veneus tromboembolisme (embolie), cerebrovasculaire accidenten
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Liu LJ, Yin XY, Ikeda K, Sullivan DH, Eisen HJ. Micronutrients, inflammation and congestive heart failure
among the elderly: nutritional perspectives on primary prevention and clinical. Clinical and Experimental
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Cardiovascular lesions in cobalt-vitamin B12 deficient sheep. Mohammed R, Lamand M.; Ann Rech Vet.
1986;17(4):447-50.
TIA, (mini-)beroerte/CVA, "silent brain infarcts"
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Weikert C, Dierkes J, Hoffmann K, Berger K, Drogan D, Klipstein-Grobusch K, Spranger J, Möhlig M, Luley
C, Boeing H. B Vitamin Plasma Levels and the Risk of Ischemic Stroke and Transient Ischemic Attack in a
German Cohort. Stroke 2007; 38(11):2912-8.
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Salemi G, Gueli MC, [..], Lupo I. Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin
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Arauz A, Hoyos L, Cantú C, Jara A, Martínez L, García I, Fernández MD, Alonso E. Mild
Hyperhomocysteinemia and Low Folate Concentrations as Risk Factors for Cervical Arterial Dissection.
Cerebrovasc Dis 2007; 24(2-3):210-214.
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Yilmaz N, Yilmaz M, Pence S, Ozaslan J, Kocoglu H, Yilmaz G. Determination of serum B12 vitamin and folic
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Mac Donalds Holmes, J. ~ Cerebral manifestations of vitamin B12 deficiency. British Medical Journal.
1956; dec: 1394 - 1398.
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Vitamin B12 deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia.Naha K,
Dasari S, Vivek G, Prabhu M. BMJ Case Rep. 2012 Sep 3;2012. pii: bcr2012006632. doi: 10.1136/bcr-2012006632.
Hartaanval
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Liu LJ, Yin XY, Ikeda K, Sullivan DH, Eisen HJ. Micronutrients, inflammation and congestive heart failure
among the elderly: nutritional perspectives on primary prevention and clinical. Clinical and Experimental
Pharmacology and Physiology, 2007; 34:S14-S16.
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Verhoef P. et al. Homocysteine metabolism and risk of myocardial infarction. Relation with vitamins B6,
B12 and folate. American Journal of Epidemiology 1996;143:845-859.
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Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. Huijts M, Duits A,
Staals J, van Oostenbrugge RJ. PLoS One. 2012;7(1):e30519. Epub 2012 Jan 20.
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Anemia and mortality in heart failure patients a systematic review and meta-analysis. Groenveld HF,
Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, et al. J Am Coll Cardiol. 2008 Sep
2;52(10):818-27.
Hartkloppingen
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Autoimmune pernicious anaemia as a cause of collapse, heart failure and marked panyctopaenia in a
young patient. Carey J, Hack E. Department of Infectious Diseases, Fremantle Hospital and Health Service,
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Hartritmestoornissen, versnelde hartslag of juist zwakke, lage polsslag
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Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Beitzke M, Pfister P, Fortin J,
Skrabal F. Department of Internal Medicine, Krankenhaus der Barmherzigen Brüder, Teaching Hospital KarlFranzens-University Graz, Austria; Auton Neurosci. 2002 Apr 18;97(1):45-54.
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Autoimmune pernicious anaemia as a cause of collapse, heart failure and marked panyctopaenia in a
young patient. Carey J, Hack E.; Australia. [email protected]; BMJ Case Rep. 2012 May 8;2012.
Longziekten; Longembolie (bloedprop in longen)
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Research advances in the treatment of hyperhomocysteinemia;Cheng S, Feng J, Wang X.; China; Sheng Li
Ke Xue Jin Zhan. 2011 Oct;42(5):329-34.
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Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau Hyperphosphorylation and
memory deficits in aged rats;Wei W, Liu YH, Zhang CE, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu
GP. China.; J Alzheimers Dis. 2011;27(3):639-50.
Psychische en/of psychiatrische problemen
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252
Blz. 29, 44, 50, 56, 61, 69, 71, 79, 112, 115, 184, 186, 191, 255 “Is het Misschien B12-tekort?” Sally M.
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Domisse, J. ~ Subtle vitamin B12 deficiency and psychiatry: a largely unnoticed but devastating relation
ship. Medical Hypotheses. 1991; 34 (2): 131 - 140.
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Psychiatric manifestations of vitamin B12 deficiency: a case report. Durand C, Mary S, Brazo P, Dollfus S.
France. Encephale. 2003 Nov-Dec;29(6):560-5 Vitamin B12 deficiency associated with symptoms of
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Angsten
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Goggans, F.C. ~ A case of mania secondary to vitamin B12 deficiency. American Journal of Medicine. 1984;
141 (2):300 - 301.
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Parasitophobia as the presenting symptom of vitamin B12 deficiency. Pope FM; Practitioner. 1970
Mar;204(221):421-2.
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Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a
British birth cohort. Mishra GD, McNaughton SA, O'Connell MA, Prynne CJ, Kuh D.;UK.
[email protected]; Public Health Nutr. 2009 Feb;12(2):166-74
Psychiatrische ziekten; stemmingswisselingen; depersonalisatie; persoonlijkheidsveranderingen (“je voelt
je niet jezelf meer”), achterdocht, paranoia, gedragsverandering
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Schulman, R. ~ A survey of vitamin B12 deficiency in an elderly psychiatric population. British Journal of
Psychiatry. 1967a; 113: 241 - 251.
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Domisse, J. ~ Subtle vitamin B12 deficiency and psychiatry: a largely unnoticed but devastating relation
ship. Medical Hypotheses. 1991; 34 (2): 131 - 140.
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Negative symptoms presenting as neuropsychiatric manifestation of vitamin B12 deficiency. Sahoo MK,
Avasthi A, Singh P. Indian J Psychiatry. 2011 Oct;53(4):370-1.
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Vitamin B12 deficiency presenting with an acute reversible extrapyramidal syndrome. Kumar S. Neurology
Unit, Department of Neurological Sciences, Christian Medical College Hospital, Vellore - 632 004, India.
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Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case
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Psychiatric syndromes in pernicious anaemia. Ko SM, Liu TC. Department of Psychological Medicine,
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Cobalamin deficiency presenting as obsessive compulsive disorder: case report. Sharma V, Biswas D.
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Vitamin B12 and folic acid serum levels in obsessive compulsive disorder. Hermesh H, Weizman A, Shahar
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B12 deficiency and psychiatric disorders: case report and literature review.Zucker DK, Livingston RL, Nakra
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Perceptiestoornis, paranoïde wanen (iets totaal anders opvatten dan wat iemand je wil vertellen
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Schulman, R. ~ The present status of vitamin B12 and folic acid deficiency in psychiatric illness. Canadian
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Schulman, R. ~ Vitamin B12 deficiency and psychiatric illness. British Journal of Psychiatry. 1967b; 113:
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Hallucineren
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Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and
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Bipolaire storing (o.a. manisch depressief)
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Wieck, H.H.; Heerklotz, B. ~ Vitamin B12-mangelzustände aus neuropsychiatrischer sicht. Medizinisches
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Unilateral tremor induced by risperidone in a patient with acute mania: vitamin B12 deficiency as possible
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Schizofrenie
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Malignant catatonia in a patient with bipolar disorder, B12 deficiency, and neuroleptic malignant
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Hyperhomocysteinemia and schizophrenia: case control study; Mabrouk H, Douki W, Mechri A, Younes
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Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in
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Ontwikkelingsstoornissen zoals ADHD, PDD-NOS en autisme
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Blz. 165 ADHD, Blz. 160, 275 PDD-NOS “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M.
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Nutrition and performance in children. Fanjiang G, Kleinman RE. USA. Curr Opin Clin Nutr Metab Care.
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Autisme problemen met contact maken en toelaten, problemen met gedrag, met cognitieve functies, met
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Vitamin B12 optic neuropathy in autism. Pineles SL, Avery RA, Liu GT.Neuro-ophthalmology Service,
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Oct;126(4):e967-70. Epub 2010 Sep 20. (NB: www.drneubrander.com hoe met vitamine B12
Methylcobalamine-injecties (jonge) autistische kinderen in de VS zeer succesvol geholpen worden.)
293
Blz. 21, 26, 43, 142, 145, 155, 158-162, 164, 165, 200, 212, 219, 233, 256, 259, 265, 266, 272-276, 280,
283-285, 290, Autisme “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
294
Hyperhomocysteinemia among Omani autistic children: a case-control study. Ali A, Waly MI, Al-Farsi YM,
Essa MM, Al-Sharbati MM, Deth RC; Oman. [email protected]; Acta Biochim Pol. 2011;58(4):547-51.
295
Vitamin supplementation reduces the level of homocysteine in the urine of autistic children. KałużnaCzaplińska J, Michalska M, Rynkowski J.;Poland; [email protected]; Nutr Res. 2011 Apr;31(4):318-21.
Depressie, diep in de put zitten; geen levenlust, geen passie meer, voor niets; opgeven; onverschilligheid;
apathie (“willen moet je ook maar kunnen”); ‘fed up’ zijn; het erbij laten zitten; gebrek aan empathie
(invoelingsvermogen). Lage B12 waarden zijn sterk gerelateerd aan het hebben van een depressie
296
In 2002 publiceerden de Nederlandse onderzoekers Tiemeier, van Tuijl, Hofman, Meijer, Kiliaan, en
Breteler een artikel over het verband tussen depressie en het hebben van (te) lage vitamine B12 waarden in
het bloed in the American Journal of Psychiatry. Het onderzoek vond plaats onder bijna 4000 ouderen. Eén
van hun conclusies: Lage B12 waarden zijn sterk gerelateerd aan het hebben van een depressie. Titel van
hun werk: “Vitamin B12, folate, and homocysteine in depression: The Rotterdam study”. 159(12):2099-101.
297
Status of Vitamins B-12 and B-6 but Not of Folate, Homocysteine, and the Methylenetetrahydrofolate
Reductase C677T Polymorphism Are Associated with Impaired Cognition and Depression in Adults; Moorthy
D, Peter I, [..], Troen AM. J Nutr 2012; 142(8):1554-60 Skarupski KA, Tangney C, [..],
298
Morris MC. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms
among older adults over time. Am J Clin Nutr 2010; 92(2):330-5.
299
Treatment of depression: time to consider folic acid and vitamin B12, Alec Coppen, Christina BolanderGouaille Journal of Psychopharmacology 19(1) (2005) 59-65J Psychopharmacol. 2005 Jan;19(1):59-65.
332
Sánchez-Villegas A, Doreste J, [..], Martínez-González MA. Association between folate, vitamin B(6) and
vitamin B(12) intake and depression in the SUN cohort study. J Hum Nutr Diet 2009; 22(2):122-33.
Concentratiegebrek niet goed helder meer kunnen denken, duf zijn, “alsof er watten in het hoofd zitten”,
sufheid, lichtheid in het hoofd
300
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Conversion from Mild Cognitive Impairment to Dementia: Influence of Folic Acid and Vitamin B12 Use in
the VITA Cohort.; Blasko I, Hinterberger M, Kemmler G, Jungwirth S, Krampla W, Leitha T, Heinz Tragl K,
Fischer P.;I. Blasko, Austria, [email protected].; J Nutr Health Aging. 2012;16(8):687-94.
302
Psychiatric manifestations of vitamin B12 deficiency: a case report. Durand C, Mary S, Brazo P, Dollfus S.
France. Encephale. 2003 Nov-Dec;29(6):560-5 Vitamin B12 deficiency associated with symptoms of
frontotemporal dementia. Blundo C, Marin D, Ricci M.;Italy. [email protected];
303
Neurol Sci. 2011 Feb;32(1):101-5.
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Intelligentie, de potentie van het in wezen aanwezige IQ blijft onbenut
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Blz. 63, 259, 262, 264-266, 277, 278 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
305
Louwman MWJ et al. Signs of impaired cognitive function in adolescents with marginal cobalamin status.
Am J Clin Nutr 2000;72:762-769.
306
Tangney CC, Tang Y, [..], Morris MC. Biochemical indicators of vitamin B12 and folate insufficiency and
cognitive decline. Neurology 2009; 72(4):361-7.
307
Stolhoff, K.; Schulte, F.J. ~ Vitamin B12 and brain development. Europian Journal of Pediatrics. 1987; 146:
201 – 205.
308
Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Vogiatzoglou A, Refsum
H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD. Department of Physiology, Anatomy
and Genetics, University of Oxford, Le Gros Clark Building, South Parks Rd., Oxford OX1 3QX, UK.
[email protected]; Neurology. 2008 Sep 9;71(11):826-32.
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Low vitamin B-12 status and risk of cognitive decline in older adults. Clarke R, Birks J, Nexo E, Ueland PM,
Schneede J, Scott J, Molloy A, Evans JG. University of Oxford, . [email protected]; Am J Clin Nutr.
2007 Nov;86(5):1384-91.
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A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Kang JH,
Cook N, Manson J, Buring JE, Albert CM, Grodstein F.Channing Laboratory, Boston, MA 02115, USA.
[email protected]; Am J Clin Nutr. 2008 Dec;88(6):1602-10.
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Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline. Feng L.Folic acid and
vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with
depressive symptoms--the Beyond Ageing Project: a randomized controlled trial. [Am J Clin Nutr. 2012; Am J
Clin Nutr. 2012 May;95(5):1289-90
Vergeetachtigheid, korte termijn-geheugenproblemen
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Blz. 33, 34, 43, 44, 46, 47, 50, 51, 56, 60, 61, 69, 82, 83, 85, 88, 101, 105, 112, 115, 152, 164, 178, 184,
186, 192, 208, 255 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
313
Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination. Tangney CC, Aggarwal
NT, [..], Morris MC.; Neurology 2011; 77(13):1276-82
325
Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Bowman GL, Silbert LC,
[..], Quinn JF. Neurology 2012; 78(4):241-9.
Woordvindingsproblemen
314
Blz. 143, 158, 159, 162, 164, 261, 262, 263, 271, 278, 281-283 “Is het Misschien B12-tekort?” Sally M.
315
Tangney CC, Aggarwal NT, [..], Morris MC. Vitamin B12, cognition, and brain MRI measures: A crosssectional examination. Neurology 2011; 77(13):1276-82
Geen gevoel van well-being, de levens-‘juice’; de levenslust, het ‘joie de vivre’, de humor, de relativering, de
pit, de durf, de flair: het is er allemaal, beetje bij beetje, als het ware uitgeknepen en uitgeslopen. Er is
toenemend gevoel van chagrijnigheid, humeurigheid, prikkelbaarheid ("kort lontje"), van mogelijk
plotselinge agressie en/of stemmingswisselingen. Er kan sprake zijn van toenemend onredelijk gedrag, tot en
met ernstige psychische klachten, paniekaanvallen en zelfs suïcidaal gedrag
316
Blz. 23, 34, 43, 44, 47, 50, 51, 54, 61, 62, 80, 83, 85, 88, 105, 106, 107-112, 114, 115, 118, 132, 165, 178,
186, 209, 215, 255, 269 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
317
Sánchez-Villegas A, Doreste J, [..], Martínez-González MA. Association between folate, vitamin B(6) and
vitamin B(12) intake and depression in the SUN cohort study. J Hum Nutr Diet 2009; 22(2):122-33.
318
Eilenburg, M.D. ~ Psychiatric illness and pernicious anaemia: a clinical re-evaluation. Journal of Mental
Science. 1960; 106: 1539 - 1548.
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A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological
syndrome. Kalita J, Agarwal R, Chandra S, Misra UK. Nutr Neurosci. 2012 Jul 9.
320
Subtle vitamin-B12 deficiency and psychiatry: a largely unnoticed but devastating relationship?Dommisse
J.; Med Hypotheses. 1991 Feb;34(2):131-40.
Slecht kunnen slapen
321
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Chronobiological sleep disorders and their treatment possibilities.Brunner DP, Wirz-Justice A.Abteilung
für Chronobiologie, Psychiatrische Universitätsklinik, Basel; Ther Umsch. 1993 Oct;50(10):704-8.
323
Vitamin B12 treatment for sleep-wake rhythm disorders. Okawa M, Mishima K, Nanami T, Shimizu T,
Iijima S, Hishikawa Y, Takahashi K.; Japan. Sleep. 1990 Feb;13(1):15-23.
324
Dementia: classification and aspects of treatment. Gottfries CG. Sweden; Psychopharmacol Ser.
1988;5:187-95.
Psychose
337
Blz. 40, 44, 46, 55, 58, 80, 88, 90, 101, 105, 110, 111, 113, 116, 209, 222, 235, 269, 290 “Is het Misschien
B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
338
Vitamin B12 and folate serum levels in newly admitted psychiatric patients Vladimir Lerner, Michael
Kanevsky, Tzvi Dwolatzky, Tsvi Rouach, Ram Kamin, Chanoch Miodownik Clinical Nutrition (2006) 25, 60-67.
339
Evans, Dwight L.; e.a. ~ Organic psychosis without anemia or spinal cord symptoms in patients with
vitamin B12 deficiency. American Journal of Medicine. 1983; 140 (2): 218 - 221.
340
Medizinische Klinik ~ Funiculäre spinalerkrankungen und B12 avitaminotische Psychose. Medizinische
Klinik (München). 1967; 62: 767 - 770.
341
Wieck, H.H.; e.a. ~ Funktionspsychosen als manifestationen der B12-avitaminosen. Deutsche Medizinische
Wochenschrift (Stuttgart). 1969; 94: 1473 - 1476.
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report. Tufan AE, Bilici R, Usta G, Erdoğan A. Assistant Professor, Abant Izzet Baysal University Medical
Faculty, Department of Child and Adolescent Psychiatry, Baysal, Turkey. [email protected].; Child
Adolesc Psychiatry Ment Health. 2012 Jun 22;6(1):25.
343
Acute psychotic depression as a sole manifestation of vitamin B12 deficiency.;Bar-Shai M, Gott D, Marmor
S.; Israel. [email protected]; Psychosomatics. 2011 Jul-Aug;52(4):384-6.
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NB: Een psychose kan ook geprovoceerd worden door gebruik van lachgas (Distikstof(mon)oxide; N2O)
met als gevolg een acuut groot Vitamine B12-tekort: Nitrous oxide "whippit" abuse presenting with
cobalamin responsive psychosis. Sethi NK, Mullin P, Torgovnick J, Capasso G.;Department of Neurology, Saint
Vincent's Hospital and Medical Centers, New York, NY 10011, USA. [email protected]; J Med
Toxicol. 2006 Jun;2(2):71-4.
345
Myeloneuropathy from whipped cream bulbs presenting as conversion disorder.Brett A; Postgraduate
Centre, Graylands Hospital, Mt Claremont, Western Australia, Australia.The Australian and New Zealand
Journal of Psychiatry [1997, 31(1):131-132]
Postnatale depressie of psychose, mede door de enorme kracht- en energie-inspanningen die een bevalling
van de vrouw vraagt, kan een lichamelijk en psychisch evenwicht, dat toch al wankel was door een Vitamine
B12-tekort, ineens helemaal omslaan.
346
Blz. 109, 110, 111, 209, 290, “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
347
http://vita-info.nl/2012/07/b12-psychose/
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The Utility of Laboratory Screening in Medically Ill Patients with Psychiatric Symptoms; Catalano G.1;
Catalano M.C.2; O'Dell K.J.2; Humphrey D.A.3; Fritz E.B.4; Annals of Clinical Psychiatry, Volume 13, Number
3, September 2001 , pp. 135-140(6)
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Neurologische klachten en uitvalsverschijnselen door verdoving met lachgas, het gebruik van lachgas
(distikstof(mon)oxide; N2O) veroorzaakt acuut een gevaarlijk gebrek aan Vitamine B12
349
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.
Flippo TS, Holder WD Jr.; Department of General Surgery, Carolinas Medical Center, Charlotte; Arch Surg.
1993 Dec;128(12):1391-5.
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Severe neurologic deficit after nitrous oxide anesthesia. Hadzic A, Glab K, Sanborn KV, Thys DM.
Department of Anesthesiology, St. Luke's-Roosevelt Hospital Center, Columbia University College of
Physicians and Surgeons, New York, New York 10025, USA; Anesthesiology. 1995 Oct;83(4):863-6.
351
Postoperative dementia: toxicity of nitrous oxide.El Otmani H, El Moutawakil B, Moutaouakil F, Gam I,
Rafai MA, Slassi I.;Service de Neurologie et Explorations Fonctionnelles, CHU Ibn Rochd, Casablanca, Maroc.;
Encephale. 2007 Jan-Feb;33(1):95-7.
352
Severe polyneuropathy after using nitrous oxide as an anesthetic. A preventable disease. Alarcia R, Ara JR,
Serrano M, García M, Latorre AM, Capablo JL.Servicio de Neurología, Hospital Miguel Servet, Zaragoza,
España; Rev Neurol. 1999 Jul 1-15;29(1):36-8.
353
Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?Schilling RF.; JAMA. 1986 Mar
28;255(12):1605-6.
354
Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Renard D,
Dutray A, Remy A, Castelnovo G, Labauge P.; France. [email protected]; Neurol Sci. 2009
Feb;30(1):75-6. Epub 2009 Jan 24. - Subacute combined degeneration caused by nitrous oxide intoxication:
case reports.Lin RJ, Chen HF, Chang YC, Su JJ. Department of Neurology, National Taiwan University Hospital,
Taipei, Taiwan; Acta Neurol Taiwan. Acta Neurol Taiwan. 2011 Jun;20(2):129-37.
355
Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature
review. Singer MA, Lazaridis C, Nations SP, Wolfe GI.;Department of Neurology, University of Texas
Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8897, USA.
[email protected]; Muscle Nerve. 2008 Jan;37(1):125-9.
Dementie (ook vroegtijdige)
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Blz. 17, 22, 23, 26, 32, 34, 40, 43, 44, 46, 47, 50, 52, 55, 56, 58, 59, 60-65, 67, 69, 70, 79, 81, 88, 89, 101,
102, 105, 108, 112, 113, 115, 132, 140, 171, 177, 178, 184, 192, 193, 208, 212, 217, 222, 226, 229, 255, 257
“Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
357
Moorthy D, Peter I, [..], Troen AM. Status of Vitamins B-12 and B-6 but Not of Folate, Homocysteine, and
the Methylenetetrahydrofolate Reductase C677T Polymorphism Are Associated with Impaired Cognition and
Depression in Adults. J Nutr 2012; 142(8):1554-60
358
Hooshmand B, Solomon A, [..], Kivipelto M. Homocysteine and holotranscobalamin and the risk of
Alzheimer disease: a longitudinal study. Neurology 2010; 75(16):1408-14.
359
Haan MN, Miller JW, et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive
impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2007; 85(2):511-7.
360
Karnaze, Dean S. ~ Low serum cobalamin levels in primary degenerative dementia. (Do some people
harbor atypical cobalamin deficiency states?.). Archives of Internal Medicine. 1987; 147: 429 - 431.
361
Mitsuyama, Y.; Kogoh, H. ~ Serum and cerebrospinal fluid vitamin B12 levels in demented patients with
CH-B12 treatment-preliminary 3 study. Japanese Journal of Psychiatry and Neurology. 1988; 42 - 1: 65 - 71.
362
Nijst, T.Q.; Wevers, R.A.; Schoonderwaldt, H.C.; e.a. ~ Vitamin B12 and folate concentrations in serum and
cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia. Journal
of Neurology, Neurosurgery and Psychiatry. 1990; 53: 951 - 945.
363
Roos, D. ~ Various degrees of dementia in a selected group of gastrectomized patients with low serum
B12. Acta Neurologica Scandinavica. 1977a; 55: 363 - 376.
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Recurrent reversible jaundice, neuropsychiatric manifestations, dementia and ataxia as manifestations of
vit. B12 deficiency.Joshi D, Kumar N, Rai A. J Assoc Physicians India. 2008 Jun;56:475-6.
365
Dementia caused by vitamin B12 deficiency. Clinical case.Behrens MI, Díaz V, Vásquez C, Donoso
A.Source,Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile; Rev Med Chil.
2003 Aug;131(8):915-9.
366
Various degrees of dementia in a selected group of gastrectomized patients with low serum B12.; Roos D,
Willanger R;. Acta Neurol Scand. 1977 May;55(5):363-76.
367
Dementia: classification and aspects of treatment. Gottfries CG. Sweden; Psychopharmacol Ser.
1988;5:187-95.
Overige aanwijzingen en symptomen
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Vermoeidheid (somnolentie), slaperigheid, algehele slapte en zwakte: domweg geen energie, geen conditie
meer, uitputtingsverschijnselen (“al moe bij het opstaan”). Ook in dit verband: Snel huilen en emotioneel
zijn, niet meer stress bestendig zijn, stressed out, burn out zijn, uitgeput, kapot, letterlijk gevloerd.
Kenmerkend citaat van een ‘Vitamine B12-patiënt’: “Ik voel me eigenlijk een bejaarde in een jong lichaam”
(waarbij wij hierbij willen aantekenen dat veel van die gezondheidsklachten die bejaarden vaak hebben, nou
juist van die typische Vitamine B12-gebreks-symtomen zijn)
368
Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Br J Nutr 1973;30:277-83.
369
Blz. 32, 34, 44, 55, 79, 83, 85, 88,152, 164, 186, 191, 211, 217, 218, 222 “Is het Misschien B12-tekort?”
Chronisch Vermoeidheid Syndroom (CVS)
370
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J Rheumatol. 1997;26(4):301-7.
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Using vitamin B-12 for the management of Chronic Fatigue Syndrome (CFS).Charles W Lapp, M.D.
ProHealth.com. February 25, 2000.
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"One-carbon metabolism and CFS," Regland B et al., presented at The Clinical and Scientific Basis of
Chronic Fatigue Syndrome (international symposium), Sydney, Australia, February 1998.
374
A pilot study of vitamin B12 in the treatment of tiredness. Ellis FR, Nasser S. Br J Nutr 1973; 30: 277-283.
375
Chronic fatigue syndrome and mitochondrial dysfunction.Myhill S, Booth NE, McLaren-Howard J.; Int J
Clin Exp Med. 2009;2(1):1-16
Fibromyalgie
376
J Rheumatol. 1997;26(4):301-7.
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Myalgic ncephalomyelitis. Simpson LO. J R Soc Med 1991;84:633.
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The rationale for using high-dose cobalamine. Lapp CW, Cheney PR .The CFIDS Chronicle Physicians’
Forum Fall; 1993;19-20.
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chronic fatigue syndrome. Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries
CG.;Sweden; Scand J Rheumatol. 1997;26(4):301-7.
Slaperigheid (veel slaap nodig hebben, zomaar spontaan in slaap kunnen vallen), heel snel moe zijn na
(geringe) inspanning, ook slecht herstellen daarvan
380
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Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. Yamada N.
Department of Psychiatry, Shiga University of Medical Science, Japan; Psychiatry Clin Neurosci. 1995
Dec;49(5-6):305-7.
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Effect of methylcobalamin (VB12) injection on sleep-wake rhythm in demented patients. Mishima K,
Okawa M, Hishikawa Y. Department of Neuropsychiatry, Akita University School of Medicine; Jpn J Psychiatry
Neurol. 1992 Mar;46(1):227-8.
383
Central administration of vitamin B12 aggravates cataplexy in canine narcolepsy. Honda K, Riehl J, Inoué
S, Mignot E, Nishino S. Sleep Disorders and Research Center, Stanford University, Palo Alto, CA 94304, USA;
Neuroreport. 1997 Dec 22;8(18):3861-5.
384
Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. Yamada, N.
Japan. 1995 Dec in Psychiatry and clinical neurosciences.
Slaapproblemen
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Ohta, T.; et al ~ Treatment of persistent sleep-wake schedule disorder in adolescents with
methylcobalamin (vitamine B12 ). Sleep. 1991a; 14 (5): 414 - 418 & Japanese Journal of Psychiatry and
Neurology. 1991b; 45 (1): 167 - 168.
386
Okawa, M.; e.a. ~ Vitamin B12 treatment for sleep-wake disorders. Sleep. 1990; 13 (1): 15 - 23.
387
Okawa, M.; Mishima, K.; Hishikawa, Y. ~ Vitamine B12 treatment for sleep-wake rhythm disorders.
Japanese Journal of Psychiatry and Neurology. 1991; 45 (1): 165 - 166.
388
Oku, H. ~ Cyanide with vitamin B12 deficiency as the cause of experimental tobacco amblyopia (niet
engelstalig). Nippon Ganka Gakkai Zasshi. 1991; 95: 158 - 164.
389
Okuda, K.; e.a. ~ Symposium on role of some of newer vitamins in human metabolism and nutrition,
vitamin B12 serum level and pregnancy. American Journal of Clinical Nutrition. 1958; 4: 440 - 443.
Lage, verlaagde weerstand (ook bij Aids), daardoor veel ziek zijn, veel gezondheidsklachten, kwaaltjes,
(bijvoorbeeld griepachtige verschijnselen) hebben. Een Vitamine B12-tekort geeft een verhoogde
vatbaarheid voor infectieziekten in alle mogelijke organen
390
Blz. 32-34, 42-44, 47, 71, 72, 79-81, 83, 85, 90, 126, 137, 171, 186, 193, 211, 217, 218, 222, 228, 234, 235,
391
Low serum vitamin B12 concentrations are associated with faster human immunodeficiency virus type 1
(HIV-1) disease progression. Tang A.M. et al. Journal of Nutrition 1997; 127:345-351.
392
Low serum cobalamin levels occur frequently in the acquired immune deficiency syndrome and related
disorders. Burkes RL, Cohen H, Krailo M, Sinow RM, Carmel R.; Eur J Haematol. 1987 Feb;38(2):141-7.
393
Vitamin B12, cognitive impairment, survival and HHV-6A. No authors listed. Posit Health News. 1998
Spring;(No 16):12-3.
Koorts (zonder duidelijke oorzaak)
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Vitamin B12 deficiency presenting as pyrexia. Negi RC, Kumar J, Kumar V, Singh K, Bharti V, Gupta D,
Kashyap R, Raina S.Department of Medicine, Indira Gandhi Medical College, Shimla-171001, Himachal
Pradesh; J Assoc Physicians India. 2011 Jun;59:379-80.
395
Periodic fever responds to vitamin B12 treatment. Naimer S, Volkov I. Israel. Rheumatol Int. 2010
Nov;30(12):1661-3.
396
Fever in megaloblastic anemia. McKee LC Jr. South Med J. 1979 Nov;72(11):1423-4, 1428.
Een verhoogde kans op vaginale- en urineweginfecties en andere infecties
397
Blz. 28, 44-46, 54, 92, 100, 168, 173, 175, 176, 178, 196, 282 “Is het Misschien B12-tekort?” Sally M.
398
The Megaloblastic Anemias. Herbert, Victor; Grune and Stratton, 1959b.
399
Vitamin B12, folic acid, and the treatment of megaloblastic anemias. Herbert, Victor. In: The
pharmacological basis of therapeutics, Goodman, L.S. and Gilman 8th. ed. 1990; 1294 - 1302.
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Macrocytose, polyneuropathie en achterstrengstoornis door malabsorptie van eiwitgebonden vitamine
B12. Mazure, A.; Bieger, R.; Lambrecht, P.C.L.A.; Wiarda, K.S. Nederlands Tijdschrift voor de Geneeskunde.
1990; 134 (13): 660 - 662. En ‘omgekeerd’ werkt Vitamine B12 suppletie
401
Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected
with hepatitis C virus. Alba Rocco, Debora Compare, Pietro Coccoli, Ciro Esposito, Antimo Di Spirito, Antonio
Barbato, Pasquale Strazzullo, Gerardo Nardone. Gut, July 18, 2012 DOI: 10.1136/gutjnl-2012-302344
Chronische hoest
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Vitamin B12 Deficiency is a Common Cause for Chronic Coughing, Dr. David Jockers,
www.naturalnews.com; XXI World Allergy Congress (WAC): Abstract 290. Presented December 8, 2009.
403
Unexplained chronic cough and vitamin B-12 deficiency.Bucca CB, Culla B, Guida G, Sciascia S, Bellone G,
Moretto A, Heffler E, Bugiani M, Rolla G, Brussino L.; Italy. [email protected]; Am J Clin Nutr. 2011
Mar;93(3):542-8.
Slechte wondgenezing
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Effect of vitamin B12 on wound healing. FINDLAY CW Jr.; Proc Soc Exp Biol Med. 1953 Mar;82(3):492-5.
Astma, kortademigheid
407
408
Annibaro B. et al. Journal of Allergy and Clinical Immunology 90(1), p.103, 1992.
409
Biermer's disease and auto-immune haemolytic anaemia, Nafil H, Tazi I, Mahmal L.; Service
d'hématologie, CHU Mohamed VI, Université Cadi Ayyad, Marrakech, Morocco. [email protected]
Biol Clin (Paris). 2012 Jul-Aug;70(4):480-2.
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Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. Fimognari
FL, Loffredo L, Di Simone S, Sampietro F, Pastorelli R, Monaldo M, Violi F, D'Angelo A.; Italy.
[email protected] ; Nutr Metab Cardiovasc Dis. 2009 Nov;19(9):654-9. Epub 2009 Mar 17.
Het vaak koud hebben
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“Eén van mijn klachten is het steeds verschrikkelijk koud hebben. Soms zijn het alleen koude rillingen en
voelen m'n ledematen niet eens superkoud aan, maar soms ook ben ik echt door en door koud. De
verwarming staat dan flink te loeien en soms zit ik 's avonds op de bank met joggingpak, hempje, t-shirt,
sjaal, dikke sokken en heb ik het nog steeds koud”. Van het forum van
www.stichtingb12tekort.nl/forum/index.php?topic=14419.0
412
http://www.fonteine.com/b12_tekort.html
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A hot cold man. Frostbite in summer? Polyneuropathy, vitamin B12 deficiency. Urch T.; MMW Fortschr
Med. 2010 Jun 17;152(24):5.
Vlammend-branderig gevoel op de huid
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The critical role of vitamin B12. Volkov I. Phys Sportsmed. Phys Sportsmed. 2008 Dec;36(1):34-41;
Department of Family Medicine, Ben-Gurion University of the Negev, Beer-Sheva, 84105, IL.
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A role for B₁₂ in inflammatory bowel disease patients with suppurative dermatoses? An experience with
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Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity.
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Ontstekingen in het spijsverteringskanaal (tot aan darmperforatie toe), veel moeten boeren.
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Sharma P, Topalovski M, Mayo MS, Sampliner RE, Weston AP. Helicobacter pylori Eradication
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Misselijkheid
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Neuropsychiatric disorders caused by cobalamine deficiency in the absence of anemia or macrocytosis.
Lindenbaum,; e.a. New England Journal of Medicine. 1988; 318: 1720 - 8.
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Small bowel contamination and vitamin B12 deficiency in the elderly. Chesner IM, Montgomery RD. J Clin
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Verminderde stofwisseling
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Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic
randomised controlled trial. Favrat B, Vaucher P, [..], Verdon F. BMC Fam Pract 2011; 12:2
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Megaloblastic anaemia due to vitamin B12 deficiency caused by small intestinal bacterial overgrowth:
possible role of vitamin B12 analogues. Murphy MF, Sourial NA, Burman JF, Doyle DV, Tabaqchali S, Mollin
DL.; Br J Haematol. 1986 Jan;62(1):7-12.
Slechte spijsvertering, (pijn in bovenbuik), vol of opgeblazen gevoel zelfs na eten van kleine of normale
hoeveelheden
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Vitamin B12 deficiency in the elderly. Baik HW, Russell RM. Annu Rev Nutr. 1999;19:357-77.
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Small intestinal bacterial overgrowth in the symptomatic elderly. Riordan SM, McIver CJ, Wakefield D,
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Geen trek in eten
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Gastric polyps in pernicious anemia: indications for polypectomy.Rickes S, Gerl H, Lochs H.; Berlin; Dtsch
Med Wochenschr. 2000 Sep 8;125(36):1035-8.
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Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B-12 deficiency and
psychomotor retardation. Katar S, Nuri Ozbek M, Yaramiş A, Ecer S.; J Pediatr Hematol Oncol. 2006
Sep;28(9):559-62.
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Vitamin B12 concentrations in psychiatric patients. Elsborg L, Hansen T, Rafaelsen OJ.; Acta Psychiatr
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Glutenintolerantie
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Cobalamine deficiency associated with neuropathy and oral mucosal melanosis in untreated glutensensitive enteropathy. Somay G, Cevik DM, Halaç GU, Abut E, Erenoglu NY.;Indian J Gastroenterol. 2005
May-Jun;24(3):120-2.
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Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12,
folate, and genetics. Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, Formenti S, De
Franchis R, Vecchi M.; Clin Gastroenterol Hepatol. 2005 Jun;3(6):574-80.
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Vitamin B12 deficiency in untreated celiac disease. Dahele A, Ghosh S.; Vitamin B12 deficiency in
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Anorexia
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Vitamin deficiency and malnutrition.Birlouez I, Cals MJ, Covi G, Dauvergne A, Faure H, Fayol V, Galabert C,
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439
Idiopathic non-obstructive hypertrophic cardiomyopathy, vitamin B12 deficiency and gastric
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Plasma total-homocysteine in anorexia nervosa. Moyano D, Vilaseca MA, Artuch R, Valls C, Lambruschini
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Neurologic complications of anorexia nervosa. Patchell RA, Fellows HA, Humphries LL.; Department of
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Optic neuropathy in a patient with vitamin B12 deficiency: a case report.Areekul S, Roongpisuthipong C,
Churdchu K, Thanomsak W.; J Med Assoc Thai. 1992 Dec;75(12):715-8.
443
NB: Er is ook sprake van de behandeling van anorexia met behulp van onder andere Vitamine b12:
Treatment of infantile anorexia with a combination of reserpine with vitamins B12, B1 and intrinsic
factor.ORTEGA CL, MICHELLI JJ.;Sem Med. 1959 Aug 30;l15(Suppl 16):376-81.
Buikpijn
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Primary gastric lymphoma presenting with vitamin B12 deficiency and achlorhydria. Drake WM, Innes DF.
Am J Gastroenterol. 1996 Dec;91(12):2605-6.
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The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B12deficiency anemia. Avcu N, Avcu F, Beyan C, Ural AU, Kaptan K, Ozyurt M, Nevruz O, Yalçin A.;Faculty of
Dentistry, Department of Oral Diagnosis and Radiology, Hacettepe Universitesi, Ankara, Turkey.
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Causes of vitamin B12 and folate deficiency. Allen LH. USDA, ARS Western Human Nutrition Research
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Functional Vitamin B12 Deficiency Represented by Elevated Urine Methylmalonic Acid Levels in Patients
with Migraine. Osman Metin İPÇİOĞLU,Ömer ÖZCAN, Mustafa GÜLTEPE, Hakan TEKELİ,Mehmet Güney
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Unusual association of Arnold-Chiari malformation and vitamin B12 deficiency.Verma R, Praharaj
HN.Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh,
India; BMJ Case Rep. 2012 Jul 9; 2012.
Maagzweer
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Increased levels of homocysteine in patients with ulcerative colitis. Akbulut S, Altiparmak E, Topal F,
Ozaslan E, Kucukazman M, Yonem O. Department of Gastroenterology, Kartal Kosuyolu High Specialty
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Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis.Chen ML, Mei Q, Xu
JM, Hu NZ, Lu CX, Fang HM.; Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Mar;14(3):185-7 Zhonghua Wei
Chang Wai Ke Za Zhi. 2011 Mar;14(3):185-7
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Darmklachten, inflammatoire darmziekten (IBD)
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Anemia and inflammatory bowel diseases. Gomollón F, Gisbert JP. Gastroenterology Unit, Clinical
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Prevalence and outcomes of anemia in inflammatory bowel disease: a systematic review of the
literature.Wilson A, Reyes E, Ofman J.Zynx Health, Beverly Hills, California 90212, USA; Am J Med. 2004 Apr
5;116 Suppl 7A:44S-49S.
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Research progress of anemia associated with inflammatory bowel diseases. Hong ZW, Ren JA. Nanjing
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Clinicopathogenetic variants of anemia in patients with intestinal inflammation. No authors listed. Ter
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Methyl deficient diet aggravates experimental colitis in rats. Chen M, Peyrin-Biroulet L, George A, Coste F,
Bressenot A, Bossenmeyer-Pourie C, Alberto JM, Xia B, Namour B, Guéant JL.; Inserm U954, Medical faculty
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Prevalence of anaemia in inflammatory bowel disease in Switzerland: a cross-sectional study in patients
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Voegtlin J, Rogler G, Ballabeni P, Pittet V, Buser A, Fried M, Beglinger C; Swiss IBD Cohort Study; J Crohns
Colitis. 2010 Dec;4(6):642-8. Epub 2010 Aug 12.
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Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Yakut M, Ustün Y,
Kabaçam G, Soykan I.Turkey. [email protected]; Eur J Intern Med. 2010 Aug;21(4):320-3. Epub 2010 Jun
8.
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Stuart.
Ziekte van Crohn
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Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B(12) deficiency in patients
with Crohns disease. Inflamm Bowel Dis 2008; 14(2):217-23.
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Crohn's disease presenting with recurrent acute polyradiculoneuropathy. El Moutawakil B, Rafai MA, Gam
I, Tahiri JM, Rhimou A, Slassi I.Service de Neurologie, CHU Ibn Rochd, Casablanca, Maroc; Rev Neurol (Paris).
2007 Feb;163(2):244-6.
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Diagnosis and management of Crohn's disease. Wilkins T, Jarvis K, Patel J.; Georgia Health Sciences
University, Augusta, 30912, USA. [email protected] ;Am Fam Physician. 2011 Dec 15;84(12):136575. Vitamin B12 deficiency revealing asymptomatic Crohn's disease. Tielman G, Allah-Kouadio E, Guillemot
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Megaloblastic anemia in a patient with Crohn's disease. Tamura J, Kubota K, Kurabayashi H, Shirakura T,
Sugai Y.; Japan; Rinsho Ketsueki. 1987 Jun;28(6):924-8.
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Macrocytic anaemias. Three fifths of patients with Crohn's disease that has not been operated on have
vitamin B12 malabsorption. Barton R.; BMJ. 1997 May 24;314(7093):1552.
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Vitamin B12 absorption after ileorectal anastomosis for Crohn's disease: effect of ileal resection and time
span after surgery. Behrend C, Jeppesen PB, Mortensen PB. Copenhagen, Denmark; Eur J Gastroenterol
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Direct and quantitative vitamin B12 absorption measurement in patients with disorders in the distal part
of the bowel. Comparison of stool spot test [SST] with whole body counting in patients with ileal pelvic
reservoir, ileostomy or Crohn's disease. Bayat M, Brynskov J, Dige-Petersen H, Hippe E, Lønborg-Jensen H.;
Copenhagen, Denmark; Int J Colorectal Dis. 1994 May;9(2):68-72.
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Megaloblastic anemia associated with diffuse intestinal Crohn's disease. Abe S, Wakabayashi Y, Hirose S.;
Rinsho Ketsueki. 1989 Jan;30(1):51-5.
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Pernicious anemia caused by Crohn's disease of the stomach. Kraus J, Schneider R.; Am J Gastroenterol.
1979 Feb;71(2):202-5.
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Remediable defects in Crohn disease: a prospective study of 63 patients. Beeken WL.; Arch Intern Med.
1975 May;135(5):686-90.
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Colitis ulcerosa
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Clin Chim Acta 2011.
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Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease.Am J Gastroenterol 2001;
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Increased levels of homocysteine in patients with ulcerative colitis. Akbulut S, Altiparmak E, Topal F,
Ozaslan E, Kucukazman M, Yonem O.;46 Istanbul, Turkey; World J Gastroenterol. 2010 May 21;16(19):24116.
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Low serum vitamin B12 is common in coeliac disease and is not due to autoimmune gastritis. Dickey W.
Eur J Gastroenterol Hepatol. 2002 Apr;14(4):425-7.
Leverproblemen-ziekten
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Serum vitamin B12 levels as indicators of disease severity and mortality of patients with acute-on-chronic
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Blz. 29, 30, 112, 119, 230, 241, 246, 261. Lever cirrose: 54, 213. Kanker: 169. “Is het Misschien B12tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Diarree (met enige regelmaat)
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Blz. 44-46, 176, 222, 287 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
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Diarrhea and novel dietary factors emerge as predictors of serum vitamin B12 in Panamanian children.
Scatliff CE, Koski KG, Scott ME. Food Nutr Bull. 2011 Mar;32(1):54-9.
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Diarrhea with vitamin B12 deficiency. Marteau P, Verkarre V, André C, Brousse N, Cellier C.; Gastroenterol
Clin Biol. 2001 May;25(5):495-7.
485
Malabsorption and deficiency of vitamin B12 in HIV-infected patients with chronic diarrhea.Ehrenpreis
ED, Carlson SJ, Boorstein HL, Craig RM.Dig Dis Sci. 1994; Dig Dis Sci. 1994 Oct;39(10):2159-62.
Nierfalen, nierproblemen
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KM, Hoffer LJ. 51(7):881-6.
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Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis
patients receiving high-dose folic acid supplementation. Koyama K, Usami T, Takeuchi O, Morozumi K,
Kimura G. Nephrol Dial Transplant 2002 ; 17(5):916-922.
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Chronic Renal Failure Promotes Severe Variant of Vitamin B 12 Deficiency; Thomas Duning, Darius Günter
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The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of
vitamins and carrier proteins; Henrik Birn Am J Physiol Renal Physiol 291: F22-F36, 2006.
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Chronic Renal Failure Promotes Severe Variant of Vitamin B 12 Deficiency; Thomas Duning, Darius Günter
Nabavi, Rainer Dziewas, Harald Kugel, Wolf-Rüdiger Schäbitz Eur Neurol 2006;56:62-65.
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The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of
vitamins and carrier proteins; Henrik Birn Am J Physiol Renal Physiol 291: F22-F36, 2006.
Ernstige langdurige constipatie
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Blz. 44, 45, 104, 165, 203-205, 222, 261 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M.
Stuart.
493
Gastric emptying in patients with vitamin B(12) deficiency. Yağci M, Yamaç K, Acar K, Cingi E, Kitapçi M,
Haznedar R.;Eur J Nucl Med Mol Imaging. 2002 Sep;29(9):1125-7.
494
The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives
or dietary fiber. Sturtzel B, Dietrich A, Wagner KH, Gisinger C, Elmadfa I.;J Nutr Health Aging. 2010
Mar;14(3):219-23.
495
Case 4-1970 — Raynaud's Phenomenon, Pyloric Obstruction and Anemia Kurt J. Isselbacher, and
Benjamin Castleman; N Engl J Med 1970; 282:211-219January 22, 1970.
Onregelmatige ontlasting
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Antony AC. Megaloblastic anemias. In: Hoffman R, Benz Ej, Shattil SS, et al., eds. Basic Principles and
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Gasvorming
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Antony AC. Megaloblastic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic
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Gewichtsverlies (mede door verlies van eetlust)
498
Jeffrey M. Stuart. .
499
Case records of the Massachusetts General Hospital. Case 13-2012. A 62-year-old man with paresthesias,
weight loss, jaundice, and anemia.Puig A, Mino-Kenudson M, Dighe AS.;N Engl J Med. 2012 Apr
26;366(17):1626-33.
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Severe vitamin B12 deficiency in infants breastfed by vegans. Roed C, Skovby F, Lund AM.; Ugeskr Laeger.
2009 Oct 19;171(43):3099-101.
501
Vitamin B12 deficiency and severe weight loss in an elderly patient.Gupta NK, Powers JS. Tenn Med. 2008
Feb;101(2):35-6.
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Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Dharmarajan TS, Adiga GU, Norkus
EP; Geriatrics. 2003 Mar;58(3):30-4, 37-8. Review.
Verlies van smaak en reuk
503
Loss of smell and taste within the scope of vitamin B 12 deficiency. Mundt B, Krakowsky G, Röder H,
Werner E.; Psychiatr Neurol Med Psychol (Leipz). 1987 Jun;39(6):356-61.
504
Reversible isolated sensory axonal neuropathy due to cobalamin deficiency.Dalla Torre C, Lucchetta M,
Cacciavillani M, Campagnolo M, Manara R, Briani C.; Muscle Nerve. 2012 Mar;45(3):428-30.
505
Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological
signs. Leishear K, Ferrucci L, Lauretani F, Boudreau RM, Studenski SA, Rosano C, Abbate R, Gori AM, Corsi
AM, Di Iorio A, Guralnik JM, Bandinelli S, Newman AB, Strotmeyer ES.; J Gerontol A Biol Sci Med Sci. 2012
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Pijnlijke tong (glossitis), de zogenoemde ‘biefstuktong’, geeft last vooral bij scherp en gekruid eten en bij
zure dranken en bij het tandenpoetsen, ijzer- en of metaalsmaak in de mond
506
Vitamin B12: an aid to oral mucous membrane healing. Brunson EG, Smith JF, Dixon R.; Oral Surg Oral
Med Oral Pathol. 1967 Jul;24(1):102-12.
507
Gastric polyps in pernicious anemia: indications for polypectomy.Rickes S, Gerl H, Lochs H.; Berlin; Dtsch
508
Bijblijven. Cumulatief Geneeskundig Nascholingssyteem. Bloed- en beenmergaandoeningen. Büscher,
H.N.; e.a. Jaargang 6, 1990 nummer 3.
509
Human vitamin B12 deficiency. Baker, S.J. World Review of Nutrition and Dietetics. 1967; 8: 62 - 126.
510
The spectrum of vitamin B12 deficiency. American Family Physician. Clementz, G.L.; Schade, S.G.1990; 41:
150 - 162.
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Glossitis with linear lesions: an early sign of vitamin B12 deficiency. Graells J, Ojeda RM, Muniesa C,
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512
Gastric polyps in pernicious anemia: indications for polypectomy. Rickes S, Gerl H, Lochs H.Dtsch Med
Wochenschr. 2000 Sep 8;125(36):1035-8
Parodontitis, ontstoken tandvlees - en daardoor ook andere gebitsproblemen
513
Folate and vitamin B12 levels in patients with oral lichen planus, stomatitis or glossitis. Thongprasom K,
Youngnak P, Aneksuk V.;Southeast Asian J Trop Med Public Health. 2001 Sep;32(3):643-7.
514
Aphthous ulcers and vitamin B12 deficiency.Weusten BL, van de Wiel A.; Neth J Med. 1998 Oct;53(4):1725.
515
Oral manifestations of vitamin B12 deficiency: a case report. Pontes HA, Neto NC, Ferreira KB, Fonseca FP,
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Allergieën voor (huis)stof, schimmel, voedsel, hooikoorts, sommige metalen
516
Case 22-1991 — A 15-Year-Old Boy with Fever of Unknown Origin, Severe Anemia, and Portal-Vein
Thrombosis; Podolsky D.K. and Lewandrowski K.B.N Engl J Med 1991; 324:1575-1584
Epilepsie (syndroom van West), epileptische aanvallen
517
West syndrome in an infant with vitamin B12 deficiency in the absence of macrocytic anaemia. Erol I,
Alehan F, Gümüs A. Division of Child Neurology, Department of Paediatrics, Baskent University Faculty of
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Recurrent seizures: an unusual manifestation of vitamin B12 deficiency.Kumar S. Neurol India. 2004
Mar;52(1):122-3.
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Vitamin B12 deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia. Naha K,
Dasari S, Vivek G, Prabhu M.; BMJ Case Rep. 2012 Sep 3;2012
Diabetes Mellitus (Suikerziekte) NB: Het gebruik van het bij Diabetes veelvoorgeschreven medicijn
Metformine, leidt tot een Vitamine B12-tekort
520
Blz. 48, 51, 54, 58, 59, 76, 127, 130, 132, 133, 136, 148, 158, 181, 203, 208, 210, 212, 226, 236, 251 “Is het
521
Het medicijn Metformine, dat heel veel diabeten slikken, veroorzaakt op zichzelf al een Vitamine B12tekort (www.hln.be). Er zijn ongeveer 800.000 mensen met type 2 diabetes en 70% daarvan gebruikt
metformine. Het middel staat in de top-10 van meest voorgeschreven medicijnen. www.spruythillen.nl
522
De Jager J, Kooy A, Lehert P, Wulffelé MG, Van der Kolk J, Bets D, et al. Long term treatment with
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Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum
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Talaei A, Siavash M, [..], Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving
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Pflipsen MC, Oh RC, [..], Topolski R. The prevalence of vitamin B(12) deficiency in patients with type 2
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Tomkin GH, Hadden DR, Weaver JA, Montgomery DA. Vitamin-B12 status of patients on long-term
metformin therapy. Br Med J 1971;2:685-7. * Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V.
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DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes
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Pongchaidecha M, Srikusalanukul V, Chattananon A, Tanjariyaporn S. Effect of metformin on plasma
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Wulffelé MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, et al. Effects of short-term
treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2
diabetes mellitus: A randomized, placebo-controlled trial. J Intern Med 2003;254:455-63. 20.
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Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM. Risk factors of vitamin B(12) deficiency in patients
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Vitamin B(12) in type 2 diabetic patients treated with metformin.Calvo Romero JM, Ramiro Lozano JM.
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Metformin associated B12 deficiency. Kumthekar AA, Gidwani HV, Kumthekar AB. J Assoc Physicians
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Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.
Mazokopakis EE, Starakis IK.Diabetes Res Clin Pract. 2012 Sep;97(3):359-67. doi:
10.1016/j.diabres.2012.06.001. Epub 2012 Jul 7.
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Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency
and hyperhomocysteinemia. Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S, Lopamudra P,
Suryanarayana P, Viswanath K, Ayyagari R, Reddy GB. Biochemistry, National Institute of Nutrition,
Hyderabad, India. PLoS One. 2011;6(11):e26747. Epub 2011 Nov 1.
535
Prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid
disease.Perros P, Singh RK, Ludlam CA, Frier BM.; UK.; [email protected]; Diabet Med. 2000 Oct;17(10):74951.
536
Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Talaei A,
Siavash M, Majidi H, Chehrei A.;University of Medical Sciences, Arak, Iran; Int J Food Sci Nutr. 2009;60 Suppl
5:71-6. Epub 2009 Feb 11.
Exocriene Pancreas Insufficiëntie (EPI), slecht werkende alvleesklier, vaak ook door een autoimmuunprobleem
537
Pancreatic Insufficiency and Vitamin B12 Malabsorption.Eugene LeBauer; Kendall Smith; Norton J.
Greenberger; Arch Intern Med. 1968;122(5):423-425.
538
Malabsorption of vitamin B12 in pancreatic insufficiency of the adult and of the child.Guéant JL,
Champigneulle B, Gaucher P, Nicolas JP.;France; Pancreas. 1990 Sep;5(5):559-67.
539
Vitamin B12 Malabsorption in Chronic Pancreatic Insufficiency — Studies Suggesting the Presence of a
Pancreatic Intrinsic Factor; Phillip P. Toskes, M.D., John Hansell, M.D., James Cerda, M.D., and Julius J. Deren,
M.D. N Engl J Med 1971; 284:627-632March 25, 1971.
540
Vitamin B12 absorption and exocrine pancreatic insufficiency in childhood.Harms HK, Kennel O, Bertele
RM, Bidlingmeier F, Böhne A.; Eur J Pediatr. 1981 Mar;136(1):75-9.
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Aften, vitamine B12 helpt ook bij de bestrijding van aften
544
Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind,
placebo-controlled trial. Volkov I, Rudoy I, [..], Press Y. J Am Board Fam Med 2009; 22(1):9-16.
545
Cyanocobalamin may be beneficial in the treatment of recurrent aphthous ulcers even when vitamin B12
levels are normal.Gulcan E, Toker S, Hatipoğlu H, Gulcan A, Toker [email protected] . Am J
Med Sci. 2008 Nov;336(5):379-82.
546
Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Wray D, Ferguson MM, Mason DK,
Hutcheon AW, Dagg JH.; Br Med J. 1975 May 31;2(5969):490-3.
Acné
547
Dupre, A.; e.a. ~ Vitamin B12 induced acne. Cutis. 1979; 24: 210 - 211.
548
Michel, P.L. ~ Un cas d'acné importante du visage consécutive a l'administration de vitamine B12. Bull.
Soc. Fr. Dermatol. Syphilol. 1968; 75: 131.
549
Braun-Falco, O. ~ Problem of vitamin B12 /B12 acne. Selected abstracts. 6 JAMA. 1976b; 235: 1387.
550
Homocysteine, folic acid and vitamin B12 levels in females with severe acne vulgaris; Arora MK, Seth S,
Dayal S.; Clin Chem Lab Med. 2012 May 14.
Reumatoïde Artritis
551
552
Journal of the American College of Nutrition 1994;13(4):351-356.
553
B12 Deficiency Myelopathy in a Patient With Long-standing Rheumatoid Arthritis. Bournia VK, Dania V,
Lachanis S, Konsta M, Iliopoulos A. J Clin Rheumatol. 2012 Oct;18(7):372-4. doi:
10.1097/RHU.0b013e318273312f.
Huidziekten-klachten, eczeem, rode vlekken, psoriasism, gordelroos, extreem droge huid, enorme jeuk
554
555
Ruedemann, R. ~ Treatment of Psoriasis with large doses of vitamin B12, 1 - 100 mg/cm3. Preliminary
clinical Report. Archives of Dermatology and Syphilology. 1954; 69: 738 - 739.
556
Volkov I, Rudoy I, Freud T, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a
randomized, double-blind, placebo-controlled trial. J Am Board Fam Med 2009;22:9-16.
557
Stucker M, Pieck C, Stoerb C, et al. Topical vitamin B12 - a new therapeutic approach in atopic dermatitis evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J
Dematol 2004;150:977-83.
558
Low B12 levels in chronic idiopathic urticaria.Mete N, Gulbahar O, Aydin A, Sin AZ, Kokuludag A, Sebik F.;
Turkey. [email protected]; J Investig Allergol Clin Immunol. 2004;14(4):292-9.
Opvallende bleekheid van het gezicht, of een opvallend vaal-gelige of grijze teint van de huid.
559
560
Reversible cutaneous hyperpigmentation and nails with white hair due to vitamin B12 deficiency. Niiyama
S, Mukai H. Dermatol. 2007 Nov-Dec;17(6):551-2. Epub 2007 Oct 19.
561
A pale woman with a gait disorder. Pernicious anemia, vitamin B12 deficiency.Stiefelhagen P.DRKKrankenhaus Westerwald, D-57627 Hachenburg; MMW Fortschr Med. 2000 Nov 16;142(46):53-4.
Vitiligo (plaatselijk verdwijnen van het pigment)
562
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in patients with
vitiligo.Karadag AS, Tutal E, Ertugrul DT, Akin KO, Bilgili SG.Turkey; [email protected]; Clin Exp
Dermatol. 2012 Jan;37(1).
563
Increased level of serum Homocysteine in vitiligo. Singh S, Singh U, Pandey SS., India.
[email protected]; J Clin Lab Anal. 2011;25(2):110-2.
564
Folic acid and vitamin B12 in vitiligo: a nutritional approach.Montes LF, Diaz ML, Lajous J, Garcia NJ.; Cutis.
1992 Jul;50(1):39-42.
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Is there a relationship between homocysteine and vitiligo? A pilot study. Shaker OG, El-Tahlawi SM.Cairo
University, Cairo 0123, Egypt. [email protected]; Br J Dermatol. 2008 Sep;159(3):720-4. Epub 2008 Jul
4.
566
Slowly progressive type 1 diabetes mellitus associated with vitiligo vulgaris, chronic thyroiditis, and
pernicious anemia. Suzuki C, Hirai Y, Terui K, Kohsaka A, Akagi T, Suda T. Department of Endocrinology,
Aomori Prefectural Central Hospital, Aomori.; Intern Med. 2004 Dec;43(12):1183-5. Improvement of vitiligo
after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Juhlin L, Olsson MJ.
Sweden; cta Derm Venereol. 1997 Nov;77(6):460-2.
567
Of juist:
Hyperpigmentatie, pigmentvlekken, spontane blauwe plekken
568
Skin hyperpigmentation and increased angiogenesis secondary to vitamin B12 deficiency in a young
vegetarian woman. Aroni K, Anagnostopoulou K, Tsagroni E, Ioannidis E.; Acta Derm Venereol.
2008;88(2):191-2.
569
Reversible knuckle hyperpigmentation in B12 deficiency.Kumar V, Sharma V.Department of Nephrology,
Postgraduate Institute of Medical Education and Research, Chandigarh, India; N Z Med J. 2011 Sep
9;124(1342):98-9.
570
Generalized hyperpigmentation of the skin due to vitamin B12 deficiency. Mori K, Ando I, Kukita A. Japan;
J Dermatol. 2001 May;28(5):282-5. Vitamin B12 deficiency: a case report of ongoing cutaneous
hyperpigmentation. Hoffman CF, Palmer DM, Papadopoulos D. USA. erderm @aol.com; Cutis. 2003
Feb;71(2):127-30; quiz 138-40.
571
Blz. 44 en 164 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Dysfasie (problemen met spreken, verkeerde woorden gebruiken, niet op het juiste woord kunnen komen,
met "dubbele tong" praten; "toetsenbordafasie").
572
Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination. Tangney CC, Aggarwal
NT, Li H, Wilson RS, Decarli C, Evans DA, Morris MC.; Neurology. 2011 Sep 27;77(13):1276-82. Erratum in:
Neurology. 2011 Nov 8;77(19):1773.
573
High frequency of low serum levels of vitamin 12 among patients attending Jordan University Hospital.
Barghouti FF, Younes NA, Halaseh LJ, Said TT, Ghraiz SM.; East Mediterr Health J. 2009 Jul-Aug;15(4):853-60.
574
Vitamin B12 and folate depletion: clinical evidence in a neurological population. Moretti R, Torre P,
Antonello RM, Cazzato G, Cattaruzza T, Scapicchio PL.; Neurologist. 2004 Nov;10(6):338-43.
Haaruitval (Alopecia Areata), kaalheid, dunner of ‘ruiger’ wordend haar, wenkbrauwen worden kaal
575
A case of vitamin B12 deficiency with broad neurologic disorders and canities. Katsuoka H, Watanabe C,
Mimori Y, Nakamura S. Third Department of Internal Medicine, Hiroshima University School of Medicine,
Japan; No To Shinkei. 1997 Mar;49(3):283-6.
576
Serum vitamin B12, folate, ferritin, and iron levels in Turkish patients with alopecia areata. Gonul M,
Cakmak SK, Soylu S, Kilic A, Gul U.; Serum vitamin B12, folate, ferritin, and iron levels in Turkish patients with
alopecia areata. Indian J Dermatol Venereol Leprol. 2009 Sep-Oct;75(5):552.
Te vroeg grijs haar krijgen
577
578
Vitamin B12 deficiency: report of a childhood case. Juangbhanit C, Nitidanhaprabhas P, Sirimachan S,
Areekul S, Tanphaichitr VS. Department of Pediatrics, Bhumipol Adulyadej Hospital, Donmuang, Bangkok,
Thailand; 1991 Jun;74(6):348-54.
579
Reversible hyperpigmentation of skin and nails with white hair due to vitamin B12 deficiency. Noppakun
N, Swasdikul D.; Arch Dermatol. 1986 Aug;122(8):896-9.
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Brokkelige ‘ongezonde’ nagels, snel splijtend of scheurend
580
Pigmentation of fingertips and nails in vitamin B12 deficiency. Ridley CM; Br J Dermatol. 1977
Jul;97(1):105-6.
581
Reversible hyperpigmentation of skin and nails with white hair due to vitamin B12 deficiency. Noppakun
N, Swasdikul D. Arch Dermatol. 1986 Aug;122(8):896-9.
582
Reversible cutaneous hyperpigmentation and nails with white hair due to vitamin B12 deficiency. Niiyama
S, Mukai H.; Eur J Dermatol. 2007 Nov-Dec;17(6):551-2
Nek- en of lage rugpijn
583
Blz 185 IHMB12tekort?
584
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study; Mauro GL,
Martorana U, Cataldo P, Brancato G, Letizia G Eur Rev Med Pharmacol Sci. 2000 May-Jun;4(3):53-8.
585
Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine
triphosphate, cytidine monophosphate, and hydroxycobalamin.Mibielli MA, Nunes CP, Cohen JC, Scussel AB
Jr, Higashi R, Bendavit GG, Oliveira L, Geller M.Brazil; Proc West Pharmacol Soc. 2010;53:5-12.
586
The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic
nonspecific low back pain: a randomised controlled trial. Chiu CK, Low TH, Tey YS, Singh VA, Shong
HK.;bSingapore Med J. 2011 Dec;52(12):868-73.
Incontinentie
587
Jeffrey M. Stuart.
588
Neurologic aspects of cobalamin deficiency Healton EB, Savage DG, Brust JC, et al.. Medicine (Baltimore)
1991;70:229-45.
589
Relationship of vitamin B12 deficiency with incontinence in older people. Rana S, D'Amico F, Merenstein
JH. J Am Geriatr Soc 1998;46:931-2.
590
Masked deficit of vitamin B12 in the patient with heterozygous beta-thalassemia and spastic paraparesis.
Bilic E, Bilic E, Zagar M, Juric S.;Department of Pediatric Haematology, University Hospital Centre Zagreb,
Croatia. [email protected]; Acta Neurol Belg. 2004 Dec;104(4):173-5.
591
Vitamin B12 deficiency and incontinence in older people. Garcia A, Smith M, Freedman M.; Can J Urol.
2000 Aug;7(4):1077-80.
Menstruatieproblemen (pijnlijk, onregelmatig, soms te lang, soms wegblijvend).
592
http://www.vitamineabcd.nl/tekort-aan-vitamine-b12
593
http://home.hetnet.nl/~hindrikdejong/symptoom.htm
Opmerkelijk: Vitamine B12 tekort kan ook leiden tot:
Fout-positieve PAP-uitstrijk bij vrouwen, een vitamine B12-tekort kan voor dysplasie (abnormale
celvorming in de baarmoederhals) zorgen, wat een foutieve uitslag kan veroorzaken
594
Oral epithelial dysplasia in vitamin B12 deficiency. Theaker JM, Porter SR, Fleming KA. England; Oral Surg
Oral Med Oral Pathol. 1989 Jan;67(1):81-3.
595
Megaloblastic anaemia and miscellaneous deficiency anaemias. The Oxford Textbook of Medicine;
Hoofdstuk 19, bladzijde 93.
596
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of
cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Tong
SY, Kim MK, Lee JK, Lee JM, Choi SW, Friso S, Song ES, Lee KB, Lee JP. Cancer Causes Control. 2011
Jan;22(1):63-72.
597
www.erasmusmc.nl/47396/388140/3448814/presdysplamuld.
598
Blz. 35, 45, 171-173, 181, 211, 222, 251, 255 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey
M. Stuart.
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Dysplasie (abnormale celvorming in de baarmoederhals)
599
600
Folate and vitamin B12 levels in abnormal pap smears: a case control study. Yüksel H, Odabasi AR, Cetin
G, Eben M, Nergiz S, Onur E.;Eur J Gynaecol Oncol. 2007;28(6):526-30.
601
Vitamin B12 status of Thai women with neoplasia of the cervix uteri. Kwanbunjan K, Saengkar P,
Cheeramakara C, Tangjitgamol S, Chitcharoenrung K.; Department of Tropical Nutrition and Food Science,
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. [email protected]; outheast Asian J
Trop Med Public Health. 2006;37 Suppl 3:178-83.
Hevige overgangsklachten
602
http://home.kpn.nl/hindrikdejong/relatiemet.htm
603
www.hematologienederland.nl/book/export/html/6
Verhoogd risico op het krijgen van kanker, een Vitamine B12-tekort kan leiden tot een op steeds grotere
schaal optredend schade aan het DNA en een gewijzigde methylering van het DNA, beide factoren die
bekend staan als belangrijke risico factoren zijn voor het krijgen van kanker
604
“Vitamin B12 deficiency may lead to an elevated rate of DNA damage and altered methylation of DNA,
both of which are important risk factors for cancer” Linus Pauling Institute in de VS. Zie ook:
http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12 .; Dec;36(1):34-41.
605
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and upregulates PP2A, proNGF, and TACE. Battaglia-Hsu SF, Akchiche N, Noel N, Alberto JM, Jeannesson E, OrozcoBarrios CE, Martinez-Fong D, Daval JL, Guéant JL. Institut National de la Santé et de la Recherche Médicale
U954, Faculté de Médecine, Nancy-Université, F-54505 Vandoeuvre-lès-Nancy, France; Proc Natl Acad Sci U
S A. 2009 Dec 22;106(51):21930-5. Epub 2009 Dec 3.
606
The master key effect of vitamin B12 in treatment of malignancy--a potential therapy?Volkov I.
Department of Family Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Lea Imenu
St. 59/2, Beer-Sheva 84514, Israel. [email protected] <[email protected]; Med Hypotheses.
2008;70(2):324-8. Epub 2007 Jul 20.
607
Vitamin B12 could be a "master key" in the regulation of multiple pathological processes. Volkov I, Press
Y, Rudoy I.Department of Family Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev,
Israel. [email protected]; J Nippon Med Sch. 2006 Apr;73(2):65-9.
NB: Er bestaan ook aanwijzingen dat extra suppletie van Vitamine B12 een positief effect heeft tegen de
verdere groei van kanker.
608
“The effect of vitamin B12 on the proliferation of malignant cells has been examined in vivo and in vitro in
numerous studies. Their results indicate that methylcobalamin inhibits the proliferation of malignant cells
and propose the possibility of methylcobalamin as a candidate of potentially useful agents for the treatment
for some malignant tumors”. The critical role of vitamin B12. Volkov I. Phys Sportsmed. Phys Sportsmed.
2008 Dec;36(1):34-41; Department of Family Medicine, Ben-Gurion University of the Negev, Beer-Sheva,
84105, IL. [email protected].
609
Effects of methylcobalamin on the proliferation of androgen-sensitive or estrogen-sensitive malignant
cells in culture and in vivo. Nishizawa, Y., T. Yamamoto, et al. (1997) Int J Vit Nutr Res 67(3): 164-170.
610
Methylcobalamin inhibits fibroblast growth factor-8 stimulated proliferation and induces apoptosis in
Shionogi carcinoma cells. Goto, G. H., H. Katayama, et al. (2008). Int J Vit Nutr Res 78(1): 21-26.
611
The inhibition of some cancers and the promotion of others by folic acid, vitamin B12, and their
antagonists. Herbert, Victor. In: Nutritional factors in the induction and maintenance of malignancy.
Butterworth, C.E. Jr. and Hutchinson, M.L. New York Academic Press 1983b; 273 - 287. En het meest recente
onderzoek: An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis. Evelyne
Deery, Susanne Schroeder, Andrew D Lawrence, Samantha L Taylor, Arefeh Seyedarabi, Jitka Waterman,
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Keith S Wilson, David Brown, Michael A Geeves, Mark J Howard, Richard W Pickersgill, Martin J
Warren.Nature Chemical Biology, 2012; DOI: 10.1038/nchembio.1086.
612
Blz. 25, 32, 45-47, 52, 148, 166-173, 175, 181, 186, 210, 242 “Is het Misschien B12-tekort?” Sally M.
Borstkanker Citaat: er is in groeiende mate sterk bewijs dat er een relatie bestaat tussen het krijgen van
borstkanker en het hebben van een vitamine B12-tekort. Blz. 46 “Could it be B12? An epidemic of
misdiagnoses, blz. 22, 167 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
613
Choi S-W. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev. 1999;57(8):250-253
614
Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer; Shumin M. Zhang,
Walter C. Willett, Jacob Selhub, David J. Hunter, Edward L. Giovannucci, Michelle D. Holmes, Graham A.
Colditz and Susan E. Hankinson; (e-mail: [email protected]); Oxford JournalsMedicine
JNCI J Natl Cancer Inst Volume 95, Issue 5Pp. 373-380.
Maagkanker, verhoogd risico op het krijgen van
615
616
De Helicobacter pylori wordt ook in verband gebracht met maagkanker. Een langdurige
maagslijmvliesontsteking kan veranderingen in het weefsel veroorzaken. Het maagslijmvlies is dan blijvend
veranderd en dat kan op termijn de kans op maagkanker vergroten. Bron:
http://www.mlds.nl/ziekten/133/helicobacter-pylori-infectie-met/klachten.
617
Het ernstig last krijgen van de helicobacter pylori wordt in verband gebracht met een Vitamine B12tekort: Kaptan, Kursad, et al. Helicobacter pylori - Is it a novel causative agent in vitamin B12 deficiency?
Archives of Internal Medicine, Vol. 160, May 8, 2000, pp. 1349-53.
618
Stopeck, Alison. Links between Helicobacter pylori infection, cobalamin deficiency, and pernicious
anaemia. Archives of Internal Medicine, Vol. 160, May 8, 2000, pp. 1229-30.
619
Pernicious anemia and gastric carcinoid tumor: case report and review. Sculco D, Bilgrami S.;Department
of Medicine, University of Connecticut Health Center, Farmington 06062, USA.; Am J Gastroenterol. 1997
Aug;92(8):1378-80.
620
Inleiding bloedziekten. Hanen, C; e.a. Stafler, wetenschappelijke uitgeverij, Alphen a/d Rijn, 1979.
Leverkanker, verhoogd risico op het krijgen van
621
The Effects of a Primary Nutritional Deficiency (Vitamin B study); Hugh D. Riordan, Nina Mikirova, Paul R.
Taylor, Cindy A. Feldkamp, Joseph J. Casciari; Food and Nutrition Sciences, Vol. 3 No. 9, 2012, pp. 1238-1244.
622
Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient
diets.Wainfan E, Dizik M, Stender M, Christman JK.New York Blood Center, New York 10021.; Cancer Res.
1989 Aug 1;49(15):4094-7.
Darmkanker, verhoogd risico op het krijgen van
623
Liu Z, Choi SW, [..], Mason JB. Mild depletion of dietary folate combined with other B vitamins alters
multiple components of the Wnt pathway in mouse colon. J Nutr 2007; 137(12):2701-8.
624
The potential cocarcinogenic effect of vitamin B12 deficiency. Friso S, Choi SW.Department of Clinical and
Experimental Medicine, University of Verona School of Medicine, Verona, Italy. [email protected]; Clin
Chem Lab Med. 2005;43(10):1158-63.
625
Role of vitamin B12 and folate deficiencies in carcinogenesis.Eto I, Krumdieck CL; Advances in
Experimental Medicine and Biology [1986, 206:313-330].
626
Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic
epithelium. Choi SW, Friso S, Ghandour H, Bagley PJ, Selhub J, Mason JB.Vitamins and Carcinogenesis
Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts
University, Boston MA 02111, USA. [email protected]; J Nutr. 2004 Apr;134(4):750-5.
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Baarmoederhalskanker, verhoogd risico op het krijgen van
627
628
Yüksel H, Odabasi AR, Cetin G, Eben M, Nergiz S, Onur E. Folate and vitamin B12 levels in abnormal pap
smears: a case control study. Eur J Gynaecol Oncol 2007; 28(6):526-30.
629
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of
cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Tong
SY, Kim MK, Lee JK, Lee JM, Choi SW, Friso S, Song ES, Lee KB, Lee JP. Department of Obstetrics and
Gynecology, East-West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea; Cancer
Causes Control. 2011 Jan;22(1):63-72. Epub 2010 Nov 5.
630
Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin
B12 in the post-folic acid fortification era. Piyathilake CJ, Macaluso M, Alvarez RD, Bell WC, Heimburger DC,
Partridge EE. Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University
Boulevard, Webb 326, Birmingham, AL 35294, USA. [email protected]; Cancer Prev Res (Phila). 2009
Jul;2(7):658-64. Epub 2009 Jun 19.
631
Vitamin B12 status of Thai women with neoplasia of the cervix uteri. Kwanbunjan K, Saengkar P,
Cheeramakara C, Tangjitgamol S, Chitcharoenrung K. Mahidol University, Bangkok, Thailand.
[email protected]; Southeast Asian J Trop Med Public Health. 2006;37 Suppl 3:178-83.
632
Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin,
and vitamin B12. Hernandez BY, McDuffie K, Wilkens LR, Kamemoto L, Goodman MT. Cancer Research
Center of [email protected]; Cancer Causes Control. 2003 Nov;14(9):859-70.
633
Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology. de la Calle M, Usandizaga R,
Sancha M, Magdaleno F, Herranz A, Cabrillo E.Department of Obstetrics and Gynaecology, Hospital La Paz,
Paseo de la Castellana n 261, 28046 Madrid, Spain; Eur J Obstet Gynecol Reprod Biol. 2003 Apr
25;107(2):125-34.
Longkanker, verhoogd risico op het krijgen van
634
635
Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA
hypomethylation.Piyathilake CJ, Johanning GL, Macaluso M, Whiteside M, Oelschlager DK, Heimburger DC,
Grizzle WE. Department of Nutrition Sciences, University of Alabama at Birmingham 35294, USA; Nutr
Cancer. 2000;37(1):99-107. Nutr Cancer. 2000;37(1):99-107.
Mondkanker, verhoogd risico op het krijgen van
636
637
Diet and oral premalignancy in female south Indian tobacco and betel chewers: a case-control study.
Carley KW, Puttaiah R, Alvarez JO, Heimburger DC, Anantha N.Department of International Health, University
of Alabama at Birmingham, Birmingham, AL 35294-0008, USA; Nutr Cancer. 1994;22(1):73-84.
Onvruchtbaarheid bij de vrouw, verhoogd risico op
638
Vitamin B12 deficiency and infertility: report of a case. International Journal of Fertility. Sanfilippo, J.S.
1991; 36: 36 - 38.
639
Prevalence of low serum cobalamin in infertile couples. Pront R, Margalioth EJ, [..], Elstein D. Andrologia
2009; 41(1):46-50 .
640
Vitamin B12 deficiency, infertility and recurrent fetal loss. M Bennett - The Journal of reproductive
medicine, 2001 - ncbi.nlm.nih.gov.
641
Cobalamin deficiency and infertility. Menachem Y, Cohen AM, Mittelman M. Am J Hematol. 1994
Jun;46(2):152.
642
Vitamin B12 deficiency and infertility: report of a case. Sanfilippo JS, Liu YK. Department of Obstetrics and
Gynecology, University of Louisville, School of Medicine, Kentucky; Int J Fertil. 1991 Jan-Feb;36(1):36-8.
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Pernicious anemia, vitiligo, and infertility. Gulden KD.Wilkes Family Health Center, North Wilkesboro, NC;
J Am Board Fam Pract. 1990 Jul-Sep;3(3):217-20. Ook: blz. 35, 45, 47, 48, 196-200, 202, 222, 229 “Is het
Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart. . In dat verband ook te noemen:
Verminderde spermakwaliteit bij de man
644
Clinical experience with methylcobalamin (CH3-B12) for male infertility. Isoyama R, Kawai S, Shimizu Y,
Harada H, Takihara H, Baba Y, Sakatoku J.; Hinyokika Kiyo. 1984 Apr;30(4):581-6.
645
Clinical experience of methylcobalamin (CH3-B12)/clomiphene citrate combined treatment in male
infertility. Isoyama R, Baba Y, Harada H, Kawai S, Shimizu Y, Fujii M, Fujisawa S, Takihara H, Koshido Y,
Sakatoku J. Hinyokika Kiyo. 1986 Aug;32(8):1177-83.
646
(Herhaalde) Miskramen, verhoogd risico op
647
)
648
Vitamin B12 deficiency: Is it underestimated in pregnant women?, Robert H. Glew, Denis M. McCarthy &
Dorothy J. Vanderjagt, (Received 26 October 2004; accepted 28 December 2004), ISSN 0001-6349 print/ISSN
1600-0412 online # 2006 Taylor & Francis DOI: 10.1080/00016340500438074.
649
Bennett M. Vitamin B12 deficiency, infertility and recurrent fetal loss.J Reprod Med. 2001; 46(3):209-12
650
Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Goddijn-Wessel TAW et al. Eur
J Obtetrics, Gynecology, Reproduction & Biology 1996;66:23-29.
651
VitaminB12 deficiency infertility and recurrent fetal loss Bennett M. J Reprod Med 2001 Mar;46(3):209-12
652
Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development.
Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. School of Medicine, Trinity College Dublin, Ireland.
[email protected]; Food Nutr Bull. 2008 Jun;29(2 Suppl):S101-11; discussion S112-5
Geboorteafwijkingen, verhoogd risico op (bijv. neurale buisdefecten, hersenletsel, open ruggetje,
aangeboren hartafwijkingen, groeivertraging in de baarmoeder)
653
654
Neural-tube defects are associated with low concentrations of cobalamin (Vitamin B12) in amniotic fluid ,
M. T. Steen, A. M. Boddie, A. J. Fischer, W. Macmahon, D. Saxe, K. M. Sullivan, P. P. Dembure AND L. J. Elsas
Prenat. Diagn. 18: 545-555 (1998)
655
Vitamin B12 deficiency in children and adolescents, Sonja A. Rasmussen, Paul M. Fernhoff, and Kelley S.
Scanlon J Pediatr 2001;138:10-7. 9/19/112160
Vroeggeboorten, verhoogd risico op
656
657
Terugkerende cystitis. www.uitdaging.net/gezond/vitaminepep.html
658
www.rightdiagnosis.com/v/vitamin_b12_deficiency/symptoms.htm
Verlies van libido (m/v)
659
Blz. 44, 45, 102, 202-204, 212 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Erectieproblemen
660
Blz. 203-205 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
Alle auto immuunziekten zijn verdacht in relatie tot een Vitamine B12-tekort
661
Vitamin B12 and health.Ryan-Harshman M, Aldoori W. FEAST Enterprises, 947 Oshawa Blvd N, Oshawa,
ON L1G 5V6. [email protected]; Can Fam Physician. 2008 Apr;54(4):536-41.
662
The critical role of vitamin B12. Volkov I.Department of Family Medicine, Ben-Gurion University of the
Negev, Beer-Sheva, 84105, IL. [email protected]; Phys Sportsmed. 2008 Dec;36(1):34-41.
662
Jeffrey M. Stuart. Bijvoorbeeld:
© VitamineB12nu.nl
Multiple Sclerosis (MS)
663
Blz. 17, 21, 25, 26, 43, 52, 78, 79, 83, 85-94, 96-101, 103, 118, 158, 171, 190, 212, 254, 257, 287 “Is het
Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart. .
664
Vitamin B12 metabolism in Multiple Sclerosis; Reynolds E.H.,Bottiglieri T; Laundy M; Crellin RF; Kirker SG
Archives of Neurology, 1992 Jun, 49(6):649-52.
665
Multiple sclerosis and vitamin b12 metabolism; Reynolds EH Journal of neuroimmunology, 1992 oct, 40(23):225-30.
666
Vitamin B12 and its relationship to age of onset of multiple sclerosis; Sandyk R; Auerbuch GI. International
Journal of Neuroscience, 1993 Jul-Aug, 71(1-4):93-9.
667
Vitamin B12, demyelination, remyelination and repair in multiple sclerosis;Miller A, Korem M, Almog R,
Galboiz Y. J Neurol Sci 2005 Jun 15;233(1-2):93-7.
668
Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple
sclerosis; Kira J, Tobimatsu S, Goto I Intern Med. 1994 Feb;33(2):82-6.
669
Vitamin B12 deficiency can mimic multiple sclerosis – report of two cases Iwona Kurkowska-Jastrzebska,
Wojciech Wicha, Anna Czlonkowska Case Rep Clin Pract Rev, 2006; 7: 64-68.
670
Multiple Sclerosis and Vitamin B12 Metabolism [editorial]Reynolds E.H. Journal of Neurology,
Neurosurgery and Psychiatry, 1992 may.
671
Nijst, T.Q.; Wevers, R.A.; Schoonderwaldt, H.C.; e.a. ~ Vitamin B12 and folate concentrations in serum
and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia.
Journal of Neurology, Neurosurgery and Psychiatry. 1990; 53: 951 - 945.
672
Arch Neurol 1992;49:649.
673
Reynolds, E.H.; e.a. ~ Multiple sclerosis and vitamin B12 deficiency. In: Biomedicine and physiology of
vitamin B12. Linnell, J.C.; Bhatt H.R. London, England: Children's Medical Charity. 1990; 121 - 128.
674
Reynolds, E.H.; e.a. ~ Multiple sclerosis and vitamin B12 metabolism: a new clue. Journal of Neurology,
Neurosurgery and Psychiatry. 1988; 51: 739.
675
Reynolds, E.H.; Linnel, J.C. ~ Vitamin B12 deficiency, demyelination, and multiple sclerosis. Lancet. 17
october 1987; 920.
676
Reynolds, E.H.; Linnell, J.C. Faludy, J.E.; e.a. ~ Some patients with multiple sclerosis have a disorder of
vitamin B12 metabolism. Neurology. 1989; 39 (supplement): 418.
677
Reynolds, E.H. ~ Multiple sclerosis and vitamin B12 metabolism. Journal of neurology, neurosurgery and
psychiatry. 1992a; 55 (5): 339 - 340.
678
Reynolds, E.H. ~ Vitamin B12 metabolism in multiple sclerosis. Archive of Neurology. 1992b; 49 (6): 649 652.
679
Reynolds, R.R.C.P.; e.a. ~ Multiple sclerosis associated with vitamin B12 deficiency. Archive of Neurology.
1991; 48 (8): 808 - 811.
680
Unusual association of Arnold-Chiari malformation and vitamin B12 deficiency. Verma R, Praharaj HN.
BMJ Case Rep. 2012 Jul 9;2012.
681
Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple
sclerosis; J Kira, S Tobimatsu, I Goto - Intern Med, 1994 - life-choice.net.
682
Functional vitamin B12 deficiency. Turner MR, Talbot K. Department of Neurology, John Radcliffe
Hospital, University of Oxford, Oxford, UK; Pract Neurol. 2009 Feb;9(1):37-41.
683
J Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Miller A, Korem M, Almog R,
Galboiz Y.Division of Neuroimmunology and Multiple Sclerosis Center, Carmel Medical Center, Haifa 34362,
Israel. [email protected]; Neurol Sci. 2005 Jun 15;233(1-2):93-7.
ALS (Amyotrofische Letraal Sclerose)
684
© VitamineB12nu.nl
Bij baby's en kinderen
Onderstaande symptomen komen ook voor in de symptomenlijst maar zijn hier extra onderbouwd met onderzoek
naar kinderen.
Als de moeder een vitamine B12-tekort heeft is het zeer waarschijnlijk dat ook haar baby een vitamine B12-tekort zal
hebben. Vitamine B12 wordt doorgegeven in de moedermelk en bij de vorming van de foetus.
Naar schatting hebben 2 tot 5% van alle kinderen last van een Vitamine B12-tekort. Dat zijn er in Nederland dus vele
tienduizenden. Vitamine B12-tekort bij kinderen kan leiden tot:
• Groeiachterstand van de foetus
686
Serum homocysteine level and its association with folic acid and vitamin B12 in the third trimester of
pregnancies complicated with intrauterine growth restriction. Gadhok AK, Sinha M, Khunteta R, Vardey SK,
Upadhyaya C, Sharma TK, Jha M. Clin Lab. 2011;57(11-12):933-8.
687
Severe Anaemia during Late Pregnancy. Akhtar M, Hassan I.School of Medicine, Keele University,
Staffordshire ST5 5BG, UK; Case Rep Obstet Gynecol. 2012;2012:485452. Epub 2012 Sep 4.
688
Anemia in pregnancy. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No.
95: Obstet Gynecol. 2008 Jul;112(1):201-7.
689
Determinants of Cobalamin Status in Newborns; Guttormsen, Trond Markestad, Einar Solheim and Helga
Refsum, Anne-Lise Bjørke Monsen, Per Magne Ueland, Stein Emil Vollset, Anne Berit 2001;108;624-630
Pediatrics.
• Aangeboren aandoeningen ivm. het niet sluiten van de neurale buis (open ruggetje, spina bifida)
690
Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring
in a high-risk area of China. Zhang T, Xin R, [..], Zheng X. Public Health Nutr 2008; juni 12:1-7
691
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect
prevalence and no folic Acid fortification;Molloy AM, Kirke PN, [..], Mills JL. Pediatrics 2009; 123(3):917-23.
692
Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients. Gaber KR, Farag MK,
Soliman SE, El-Bassyouni HT, El-Kamah G. Clin Lab 2007;53(1-2):69-75
693
Homocysteine metabolism in pregnancies complicated by neural-tube defects. Mills J. et al. The Lancet
1995;345:149-151.
694
Neural tube defects and elevated homocysteine levels in amniotic fluid. Steegers-Theunissen RP.
American Journal of Obstetrics and Gynecology 1995;172:1439-1441.
695
Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida. Groenen, P.M.W.,
Van Rooij, I.A.L.M., Peer, P.G.M., Gooskens, R.H., Zielhuis, G.A. en Steegers-Theunissen, R.P.M. American
Journal of Obstetrics and Gynecology; 2004, 191: 7-11.
696
Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects. Afman, L.A.,
Van der Put, N.M.J., Thomas, C.M.G., Trijbels, J.M.F. en Blom, H.J.; Q.J.Med. 2001; 94: 159-166.
697
Vitamin B12 insufficiency and the risk of fetal neural tube defects. Overzichtsartikel: Ray, J.G., Blom, H.J.
Q. J. Med. 2003, 96: 289-295.
698
Neural-tube defects are associated with low concentrations of cobalamin (Vitamin B12) in amniotic fluid;
M. T. Steen, A. M. Boddie, A. J. Fischer, W. Macmahon, D. Saxe, K. M. Sullivan, P. P. Dembure AND L. J. Elsas
Prenat. Diagn. 18: 545-555 (1998).
699
Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development.
Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. School of Medicine, Trinity College Dublin, Ireland.
[email protected]; Food Nutr Bull. 2008 Jun;29(2 Suppl):S101-11; discussion S112-5
• Achterstand van de lichamelijke groei, neurologische en motorische problemen, uitval, verlamming
700
Graham, S.M., Arvela, O.M. en Wise, G.A., Long term neurologic consequences of nutritional vitamin B12
deficiency in infants. Journal of Pediatrics 1992, 121:710-714.
© VitamineB12nu.nl
701
•
Vitamin B12 deficiency in children and adolescents; Sonja A. Rasmussen, MD, MS, Paul M. Fernhoff, MD,
and Kelley S. Scanlon, PhD, RD J Pediatr 2001;138:10-7;
702
Lampkin, B.; Saunders, E.F. ~ Nutritional vitamin B12 deficiency in an infant. Journal of Pediatrics. 1969;
75: 1053 - 1055.
703
Sklar, R. ~ Nutritional vitamin B12 deficiency in a breast-fed infant of a vegan-diet mother. Clinical
Pediatrics. 1986; 25: 219 - 221.
704
Vitamin B12 deficiency in infants secondary to maternal causes. Roumeliotis N, Dix D, Lipson A. CMAJ.
2012 Oct 2;184(14):1593-8. doi: 0.1503/ cmaj.112170. Epub 2012 Jun 18.
705
Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. Yenicesu I. Faculty of Medicine,
Pediatric Hematology, Gazi University, Ankara, Turkey. [email protected]; Pediatr Hematol Oncol.
2008 Jun;25(4):365-7.
706
A child with vitamin B12 deficiency presenting with pancytopenia and hyperpigmentation. Simşek OP,
Gönç N, Gümrük F, Cetin M. Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara
06100, Turkey. J Pediatr Hematol Oncol; 2004 Dec;26(12):834-6.
707
Failure to thrive and psychomotor regression revealing vitamin B12 deficiency in 3 infants.Mathey C, Di
Marco JN, Poujol A, Cournelle MA, Brevaut V, Livet MO, Chabrol B, Michel G.Service de Pédiatrie,Centre
Hospitalier du Pays d'Aix, avenue des Tamaris, 13616 Aix-en-Provence, France. [email protected]; Arch
Pediatr. 2007 May;14(5):467-71. Epub 2007 Apr 6.
708
Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in different Age
Groups from 4 Days to 19 Years; Anne-Lise Bjørke Monsen, Helga Refsum, Trond Markestad, and Per Magne
Ueland Clinical Chemistry 49:12 2067-2075 (2003).
709
Paralysis and pernicious anemia in a young woman. Matrana MR, Gauthier C, Lafaye KM. J La State Med
Soc. 2009 Jul-Aug;161(4):228-32.
710
[Megaloblastic-vitamin B12 deficiency anemia in childhood.Mtvarelidze ZG, Kvezereli-Kopadze AN,
Kvezereli-Kopadze MA.; Georgian Med News. 2009 May;(170):57-60.
711
Megaloblastic anaemia in childhood due to vitamin B12 deficiency, report of 3 cases of congenital
selective vitamin B12 malabsorptio.Bienzle U, Olischläger A, Leupold D, Kohne E, Harnisch R, Kleihauer E.;
Klin Padiatr. 1976 Mar;188(2):97-103.
712
Neurologic findings of nutritional vitamin B12 deficiency in children. Incecik F, Hergüner MO, Altunbaşak
S, Leblebisatan G.;Turk J Pediatr. 2010 Jan-Feb;52(1):17-21.
713
Vitamin B12 deficiency in a breast fed infant. McPhee AJ, Davidson GP, Leahy M, Beare T.; Arch Dis Child.
1988 Aug;63(8):921-3.
Achterstand van de geestelijke (leer-)ontwikkeling
714
Blz. 26, 32, 142, 164, 165, 234,262-266, 270, 271, 273-276, 278, 281, 282, 285, 290 “Is het Misschien B12tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
715
Louwman, M., van Dusseldorp, M., van de Vijver, R.J.R. Thomas, C.M.G., Schneede, e.a., Signs of impaired
cognitive function in adolescents with marginal cobalamin status. American Journal of Clinical Nitrition 2000,
72: 762-769.
716
Sadowitz, P.D.; e.a. ~ Developmental regression as an early manifestation of vitamin B12 deficiency.
Clinical Pediatrics. 1986; 25: 369 - 371.
717
Stolhoff, K.; Schulte, F.J. ~ Vitamin B12 and brain development. Europian Journal of Pediatrics. 1987; 146:
201 – 205.
718
Vitamin B12 and brain development. Stollhoff K, Schulte FJ.; Eur J Pediatr. 1987 Mar;146(2):201-5.
719
Effects of vitamin B12 and folate deficiency on brain development in children.Black MM. USA.
[email protected]; Food Nutr Bull. 2008 Jun;29(2 Suppl):S126-31.
© VitamineB12nu.nl
720
•
•
•
•
•
•
•
Nutritional deficiency in oral candidosis. Jenkins WM, Macfarlane TW, Ferguson MM, Mason DK.; nt J Oral
Surg. 1977 Aug;6(4):204-10.
Geen trek in eten
721
722
Gastric polyps in pernicious anemia: indications for polypectomy. Rickes S, Gerl H, Lochs H.; Berlin; Dtsch
723
Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B-12 deficiency and
psychomotor retardation. Katar S, Nuri Ozbek M, Yaramiş A, Ecer S.; J Pediatr Hematol Oncol. 2006
Sep;28(9):559-62.
Epilepsie, (syndroom van West), epileptische aanvallen
724
West syndrome in an infant with vitamin B12 deficiency in the absence of macrocytic anaemia. Erol I,
Alehan F, Gümüs A. Division of Child Neurology, Department of Paediatrics, Baskent University Faculty of
Medicine, Ankara, Turkey. [email protected]; Dev Med Child Neurol. 2007 Oct;49(10):774-6.
725
Recurrent seizures: an unusual manifestation of vitamin B12 deficiency.Kumar S. Neurol India. 2004
Mar;52(1):122-3.
726
Vitamin B12 deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia. Naha K,
Dasari S, Vivek G, Prabhu M.; BMJ Case Rep. 2012 Sep 3;2012
Bloedafwijkingen
727
Pancytopenia due to vitamin B12 deficiency in a breast-fed infant. Yenicesu I.Faculty of Medicine,
Pediatric Hematology, Gazi University, Ankara, Turkey. [email protected]; Pediatr Hematol Oncol.
2008 Jun;25(4):365-7.
728
Severe vitamin B12 deficiency in a breast fed infant with pancytopenia. Citak FE, Citak EC. Ankara
Foundation of Children with Leukemia,Turgutlu Sokak No. 30, Gaziosmanpasa, Ankara, Turkey; J Trop
Pediatr. 2011 Feb;57(1):69-70. Epub 2009 Jul 17.
Apathie
729
Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible
mechanisms. Nutr Rev. 2008 May;66(5):250-5.
Concentratieproblemen, woordvindingsproblemen, geheugenproblemen 730 Concentratieproblemen: Blz.
21, 77, 105, 160 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
731
Geheugenproblemen: Blz. 33, 34, 43, 44, 46, 47, 50, 51, 56, 60, 61, 69, 82, 83, 85, 88, 101, 105, 112, 115,
732
Woordvindingsproblemen: Blz. 143, 158, 159, 162, 164, 261, 262, 263, 271, 278, 281-283 “Is het
Verlaagde mentale prestatie(s)
733
Stuart.
734
Verlaagd IQ, verstandelijke beperking(en): Blz. 260, 264, 277, 278, 285, 290 “Is het Misschien B12tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
735
Handicaps: Blz. 165, 233, 280 IHMB-tekort?
736
Wighton, M.C.; Manson, J.I.; e.a. ~ Brain damage in infancy and dietary vitamin B12 deficiency. Medical
Journal of Australia. 1979; 2: 1 - 3.
Prikkelbaarheid-gedragsproblemen, ongedurigheid, agressie
737
738
Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. Kalayci O, Cetin M, Kirel B, Ozdirim
E, Yetgin S, Aysun S, Gurgey A.Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara,
Turkey; Turk J Pediatr. 1996 Jan-Mar;38(1):67-72.;
© VitamineB12nu.nl
739
•
•
•
•
•
•
•
•
•
•
report. Tufan AE, Bilici R, Usta G, Erdoğan A.; Turkey. [email protected]; Child Adolesc Psychiatry Ment
Health. 2012 Jun 22;6(1):25.
Schildklierafwijkingen
740
Vitamin B12 absorption and exocrine pancreatic insufficiency in childhood.Harms HK, Kennel O, Bertele
RM, Bidlingmeier F, Böhne A.; Eur J Pediatr. 1981 Mar;136(1):75-9
741
Dissociation of the intrinsic factor--vitamin B12 complex by bile: contributing factor to B12 malabsorption
in pancreatic insufficiency. Cotter R, Rothenberg SP, Weiss JP.; Scand J Gastroenterol. 1979;14(5):545-50.
Spraakproblemen (het leren praten gebeurt veel later en minder goed), allergieklachten (voedsel, stof,
metalen, enz.)
742
Blz. 143, 158, 159, 162, 164, 262, 263, 271, 281-283, 278 “Is het Misschien B12-tekort?” Sally M. Pacholok
en Jeffrey M. Stuart.
Opvallend bleke gelaatskleur
743
Ugeskr Laeger. 2011 Aug 22;173(34):2047-8.
Eczeem, huidproblemen
744
Januchowski R. Evaluation of topical vitamin B(12) for the treatment of childhood eczema. J Altern
Complement Med 2009; 15(4):387-9
Zindelijkheidsproblemen, incontinentie
745
Jeffrey M. Stuart.
Hartritme-afwijkingen
746
Low maternal vitamin B12 status during pregnancy is associated with reduced heart rate variability
indices in young children. Sucharita S, Dwarkanath P, Thomas T, Srinivasan K, Kurpad AV, Vaz M. Matern
Child Nutr. 2012 May 24. doi: 10.1111/j.1740-8709.2012.00418.x
Krachtverlies in armen en benen (soms leidend tot noodzaak om rolstoel te gaan gebruiken)
747
Inborn error of vitamin B12 metabolism: a treatable cause of childhood dementia/paralysis. Al Essa M,
Sakati NA, Dabbagh O, Joshi S, Al Jishi EA, Rashed MS, Powe JE, Ozand PT. Department of Pediatrics, King
Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; J Child Neurol. 1998 May;13(5):239-43.
Heftige reactie op inenting(en)
748
ADHD
749
PDD-NOS
750
Autisme
751
Vitamin B12 optic neuropathy in autism.Pineles SL, Avery RA, Liu GT.Neuro-ophthalmology Service,
Division of Neuro-Ophthalmology, Hospital of the University of Pennsylvania, Department of Neurology,
University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA; Pediatrics. 2010
Oct;126(4):e967-70. Epub 2010 Sep 20.
752
Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with
autism. Bertoglio K, Jill James S, Deprey L, Brule N, Hendren RL. Department of Psychiatry and Behavioral
Sciences, University of California, Davis Medical Center, Sacramento, CA, USA; J Altern Complement Med.
2010 May;16(5):555-60
753
Blz. 21, 26, 43, 142, 145, 155, 158-162, 164, 165, 200, 212, 219, 233, 256, 259, 265, 266, 272-276, 280,
283-285, 290 “Is het Misschien B12-tekort?” Sally M. Pacholok en Jeffrey M. Stuart.
© VitamineB12nu.nl
754
•
•
www.drneubrander.com Hoe met vitamine B12 Methylcobalamine-injecties (jonge) autistische kinderen
in de VS zeer succesvol geholpen worden.
Afwijkende hersen-CT/MRI/EEG, hersenatrofie
755
Jeffrey M. Stuart.
756
Vergrote ventrikels, algehele vertraging van hersenactiviteit Blz. 264 “Is het Misschien B12-tekort?” Sally
M. Pacholok en Jeffrey M. Stuart.
Huilbaby, de Amsterdamse gezondheidswetenschapper Geertje Goedhart-de Wolf stuitte op de link tussen
een laag gehalte vitamine B12 bij de moeder en het hebben van een zogenoemde huilbaby. B12 is op
meerdere momenten belangrijk tijdens de zwangerschap. Zo speelt deze vitamine een rol bij de rijping van
het slaap-waakritme in de hersenen van de baby. Die rijping begint in de baarmoeder en gaat na de
geboorte nog enkele maanden door. Bron: gezondnu.nl
757
Maternal vitamin B-12 and folate status during pregnancy and excessive infant crying. Goedhart G, van
der Wal MF, [..], Bonsel GJ. Early Hum Dev 2011; 87(4):309-14
© VitamineB12nu.nl

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