Program Book

Trans-Pacific Workshop on
Stroke 2012
October 17-18, New Orleans, LA
Program Book
Organizing Committee
Midori A. Yenari, Univ. California San Francisco, USA
Shobu Namura, Morehouse School of Medicine, Atlanta, USA
Jialing Liu, Univ. California San Francisco, USA
Hiroaki Ooboshi, Fukuoka Dental College, Japan
Acknowledgement
This meeting is funded by a NIH R13 grant through the US-Japan Brain Research
Cooperative Program (Award # 3R01 NS040516-11S1, to Dr. Midori Yenari), the
Japan-US Science and Technology Cooperation Program Brain Research Division to
Dr. Hiroaki Ooboshi, Genentech (A member of the Roche Group) and Dr. Peter
MacLeish (Neuroscience Institute, Morehouse School of Medicine).
Conference Venue
Wyndham Riverfront Hotel
Address: 701 Convention Center Blvd
New Orleans, LA 70130
USA
Phone: 1-(504)-524-8200
Website: http://www.wyndham.com/hotels/louisiana/new-orleans/wyndham-riverfront-new-orleans/hoteloverview
Program artwork by Mrs. Katie Arimura, who is a New Orleans artist born in Japan and has been living
in New Orleans since 1965. Her award winning works have been exhibited throughout the US and
Japan.
Cover: Old houses on Magazine St., program pages: Fragrance.
Wednesday, October 17, 2012
13:00
Check-In, Turn-in presentations/Put up posters
13:30
Introduction and Welcome - Midori Yenari & Hiroaki Ooboshi
Session 1. Neurovascular Protection I
13:50-14:50
Moderator: Shobu Namura, USA
13:50
SlK2-CRTC1-CREB activation is a key player for endogenous
protective pathway in the ischemic brain - Kazuo Kitagawa, Japan
14:10
Neuregulin in neurovascular signaling and neuroprotection
- Byron Ford, USA
14:30
Protective effects of molecular hydrogen against ischemic
injury - Mami Noda, Japan
14:50-15:00
Short break
Session 2. Neurovascular Protection II
15:00-16:20
Moderator:
Mami Noda, USA
15:00
Oxidative stress, Nrf2 and blood-brain barrier drug efflux
transporters - David Miller, USA
15:20
Docosahexaenoic acid, a fish oil component, protects brain after
stroke - Ludmila Belayev, USA
15:40
Low-dose G-CSF therapy in clinical stroke
- Shunya Takizawa, Japan
16:00
Neuroprotective role of brain pericytes through PDGFRβ after
ischemic stroke - Tetsuro Ago, Japan
16:20-17:20
Coffee Break and poster session in Rex A
Session 3. Cell Based Therapies
17:20-18:00
Moderator:
Jialing Liu, USA
17:20
iPS cell transplantation for ischemic stroke – Koji Abe, USA
17:40
Intravascular neural stem cell therapy – Raphael Guzman, USA
Symposia and dinner at August Restaurant
18:30
Cocktails
19:00
Tribute to Dr. Akira Arimura, US-Japan neuroscientist
- Midori Yenari
19:15
Current topics on neuroprotection after cerebral ischemia
– Koji Abe
Thursday, October 18, 2012
7:30
Breakfast
Session 4. Cerebral Vasculature I
8:30-9:30
Moderator:
Kazuo Kitagawa, Japan
8:30
Regulation of cerebral blood flow and angiogenesis in brain
ischemia – Jialing Liu, USA
8:50
Induction of vascular tolerance – Jeff Gidday, USA
9:10
Mitochondrial influence on the cerebral vasculature during
health and disease – David Busija, USA
9:30
Short break
Session 5. Cerebral Vasculature II
Moderator:
9:40-10:20
Shunya Takizawa, Japan
9:40
Pleiotropic cerebrovasculature effects of lipid normalizing
drug fibrate – Shobu Namura, USA
10:00
Imaging the effect of microvascular clots and hemorrhages on
brain cell health and function – Chris Schaffer, USA
10:20
Coffee Break
Session 6. Immune Response in Stroke
Moderator:
10:40-12:00
Ludmila Belayev, USA
10:40
Neuroprotectin D1 in the modulation of the neuroinflammatory
response and its relevance to cerebrovascular biology
– Nicholas Bazan, USA
11:00
Adaptive immune response in stroke – Kyra Becker, USA
11:20
Innate immunity as a novel therapeutic target of brain
infarction – Hiroaki Ooboshi, Japan
11:40
Triggering receptor expressed on myeloid cells-2 (TREM-2) in
cell death and phagocytosis – Midori Yenari, USA
Session 7. Discussion and Closing Remarks
12:00
12:00-12:30
Summary and future directions
– Shobu Namura, Jialing Liu, Midori Yenari & Hiroaki Ooboshi
Poster Session
Wednesday October 17, 16:20-17:20, Rex A
P1. The effect of PComA patency on PCA hypoperfusion and infarct size
during intraluminal suture occlusion of MCA
Y. Akamatsu , H.Shimizu, A. Saito, M. Fujimura, J. Liu, and T. Tominaga.
Tohoku University Graduate School of Medicine, Japan; UCSF, San Francisco,
CA, USA.
P2. The relationship between CCL-1 and neuron/glia in the neuropathic
pain model
N. Akimoto, K. Honda, D. Uta, H. Furue, K. Imoto, Y. Takano, M. Noda.
Kyushu University. Japan
P3.
Contribution of chaperone-mediated autophagy to the survival of cells
under the hypoxic conditions
E. Dohi. Hiroshima University, Japan
P4.
The role of the innate immune and inflammatory system, triggering
receptor expressed by myeloid cells-2 (TREM2), in therapeutic
hypothermia
M. Kawabori, M. Hokari, X. N. Tang, Z. Zheng, M. Yenari. UCSF and SF VAMC,
San Francisco, CA, USA
P5.
Animal Modeling of Post-Stroke Fatigue: A Role for Disrupted Sleep
Wake Cycles?
Kunze, D. Zierath, B. Jaspers, D. Nahn, K. Becker. University of Washington,
Seattle, WA, USA
P6.
The effect of conditional ablation of neuroprogenitor cells on the
evolution of hemodynamics and synaptic connectivity after
experimental stroke
C. Sun, C. C. Lee, S. Wu, L. Ann, S. G. Kernie, R. K. Wang and J. Liu
P7.
PPARα activators, fenofibrate and Wy-14643, attenuate MyD88
elevation in the mouse brain after LPS injection
D. Li, G. Wang, S. Namura. Morehouse School of Medicine, Atlanta, GA, USA
P8.
Neuroprotectin D1 Attenuates Aberrant Neuronal Networks in
Epileptogenesis
AE Musto, T. M. Quebedeaux; C. P. Walker; D. Khoobehi and N.G.
Bazan. Neuroscience Center of Excellence, LSUHSC, New Orleans, LA, USA
P9.
Leukocytes plug cortical capillaries in Alzheimer disease mouse
models and decrease brain blood flow
N. Nishimura, C. J. Kersbergen, I. Ivasyk, J. Cruz-Hernandez, J. Zhou, J.D.
Beverly, E. Slack, G. Otte, P. Karlsson, T.P. Santisakultarm, C. Iadecola and
C.B. Schaffer. Cornell University, Ithaca, NY, USA
P10. Activation of mitochondria leads to nitric oxide-mediated dilation of
cerebral arteries.
P.V.G. Katakam, S. Dutta, E. Wappler, and D. W. Busija. Tulane University
School of Medicine, New Orleans, LA, USA
P11. GPR3 protects neurons from apoptosis, induced by different stimuli
S. Tanaka. Hiroshima University, Japan
P12. Genomic and Transcriptomic Analysis of Rat Brains following
Permanent and Transient Stroke Models
Z. Xu, G. D. Ford, A. Gates, B.D. Ford. Morehouse School of Medicine, Atlanta,
GA, USA