NFkB Pathway

Transcription

NFkB Pathway
IKK family
國區
IKKß
Er.t閉目
Rb pAb
Hu
GTX50693
IKKß antibody
Rb pAb
Hu. Ms. Rat
ICC/IF , WB
GTX83085
IKKß antibody [10A2C5B3]
Ms mAb
Hu
ELISA , IHC
GTX12140
IKKß antibody [10A9B6]
Ms mAb
Hu
IP , WB
IKKa/ß (phospho Ser176) antibody
Rb pAb
Hu , Ms , Rat
ELISA , IHC , WB
IKKa/ß (phospho Ser180/Ser181) antibody
Rb pAb
Hu , Ms , Rat
ELISA , IHC , WB
GTX107582
IKKyantibody
Rb pAb
Hu
ICC/IF , IHC-P , WB
GTX12141
IKKy antibody [46B844]
Ms mAb
Hu
WB
GTX111350
IKKE antibody
Rb pAb
Hu
ICC/IF , WB
GTX63506
IKKE antibody [EPR4904]
Rb mAb
Hu
FACS , ICC/IF , IHC , WB
IKKE (phospho Thr500) antibody
Rb pAb
Hu . Ms. Rat
口 dd國
國 tþ GTX79040
咱國 tþ GTX85606
Your Expertise, Our Antibodies, Accelerated Discovery.
曲調控血
IKKß antibody
IKK l Bv
IKKE
f1bn圓圓區姐回
GTX105690
tþ GTX79039
IKKy
B叫加'1rirmi
ICC/IF , IHC-P , WB
NFKB Pathway
之J
ELISA , IHC-P , WB
KDa
170
13095
72- ~"一
55 一
43 一
IKKß antibody (GTX105690):
ICC/IF analysis of PFA-fixed A431
cells
IKKy antibody (GTX107582):
ICCIIF analysis of methanol-fixed
HeLa cells
IKKE antibody (GTX l1 1350):
WB analysis of 293T celllysate
Regulators of NFKB pathway
區區
Bcl-10
E叫胸lriri'IiiT:1
GTX109159
BcI -10 antibody
GTX112744
BcI -10 antibody
GTX83215
BcI -10 antibody
GTX111091
GTX39761
f1bn盟國E11ll!J
Er.t閉目p
Rb pAb
Hu , Ms
個區區
IHC-P , WB
Rb pAb
Hu
Ms mAb
Hu , Ms
MAL T1 antibody
Rb pAb
Hu
ICC/IF , IHC-P , WB
MAL T1 antibody [50]
Ms mAb
Hu
IHC-P , WB
GTX102471
NIK / MAP3K14 antibody
Rb pAb
Hu
WB
GTX113057
NAK antibody
Rb pAb
Hu
WB
GTX61299
NAK antibody [EP611 Y]
Rb mAb
Hu . Ms. Rat
也吾吾 TX12116
NAK antibody [108 A4 29]
Ms mAb
Hu
MALT1
NIK
NAK
[4月 E8H8 , 4F8E3H8]
TANK
GTX59886
TANK antibody
Rb pAb
Hu. Ms. Rat
NRAF
GTX81783
NKRF antibody
Rb pAb
Hu
一一­
-.-
們
A
34- ~-
ELISA , FACS , ICC /l F, IHC
ICC/IF , IHC-P , IP , WB
ICC/IF , IHC , WB
IHC , IP
ELISA , IHC , WB
un-4-4l
D-7.qJqu
KDa
55- A B C
43 一
ICC/IF , IHC-P , WB
RU
35-
26 一
Lymphogenesis,
B-cell Maturation
55TANK
•
Kinase
Transcription F叫or
Inflammation, Immune Regulation, Proliferation, SU lVival
- - - - -.. Translocation
~ Ph叫ho
~ u川M
27 一
55 一
17 一
BcI-lO antibody (GTXI09159):
WB analysis of (A) HepG2 , (B) Molt-4 ,
and (C) Raji cells
43 一
antibody (GTXll1091):
ICC/IF analysis of PFA-fixed HeLa
cells
恥IAL TI
NAK antibody (GTX113057):
WB analysis of (A) HeLa and (B) HepG2
cells
TANK antibody (GTX59886):
WB analysis of mouse small intestine
tissue Iysate
one class 1 member (p50 or p52) and one class 11 member (p65/ReIA , RelB or c-Rel). In the cytoplasm , NF-KB heterodimer is
inhibited by IKB (inhibitor of NFKB). Upon activation by a variety of stimuli , including cytokines , T- and B- cell mitogens , virus and
stress , IKB is phosphorylated by IKK (IKB kinase) and then undergoing degradation through ubiquitin 中 roteasome system . The free
Application Reference
NFKB heterodimer then translocates to the nucleus and activate transcription. NFKB signaling is critical for the regulations of
NAK antibody [108A429] (GTX12116)
Ogasawa悶,
Nuclear factor開 KB (NFKB) is an ubiquitous transcription factor. It works only when two members form a heterodimer that comprises
immune responses , survival and proliferation . Misregulation of NFKB pathway may cause inflammatory and autoimmune diseases ,
N. et al. (2011) J Clin Biochem Nulr. 48:154-60. (ICC/IF , IHC , WB; Hu)
叭叭
viral infection and cancer
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E-mail: [email protected]
NFKB family
回m詞Emmm
區區
GTX100772
唱團ÞÞ GTX110585
NFKB p105/
GTX50377
帥 盡þ GTX79002
ÞÞ GTX27549
þ GTX85623
llbn圓圓扭扭扭
NFKB p105/p50 antibody
創世血
恥而吻
Rb pAb
Hu
NFKB p105/p50 antibody
Rb pAb
Hu
NFKB p105/p50 antibody
Rb pAb
Hu . Ms. Rat
NFKB p50 antibody
Rb pAb
Hu
NFKB p105/p50 (phospho Ser337) antibody
Rb pAb
Hu , Ms , Rat
NFKB1 (phospho Ser893) antibody
Rb pAb
Hu
Hu
ICC/IF , WB
47-
ELl SA , GSA , IP , WB
IHC , WB
NFKB p105/p50 (phospho
Se的07)
antibody
Rb pAb
NFKB p105/p50 (phospho
Se的27)
antibody
Rb pAb
Hu , Ms , Rat
甸園 þ GTX50279
NFKB p105/p50 (phospho
Se的32)
antibody
Rb pAb
Hu , Ms , Rat
Hu. Ms
ICC/IF , IHC , WB
WB
IHC , WB
ICC/IF , IHC , WB
IHC , WB
GTX50610
NFKB p100/p52 antibody
Rb pAb
GTX101150
NFKB p100 antibody
Rb pAb
Hu . Ms
GTX27972
NFKB p52 antibody
Rb pAb
Hu . Ms. Rat
IHC , IP , WB
NFKB p100/p52 (phospho Ser865) antibody
Rb pAb
Hu . Ms. Rat
ICC/IF , IHC , WB
NFKB p100/p52 (phospho Ser869) antibody
Rb pAb
Hu . Ms. Rat
ICC/IF , IHC , WB
þ GTX79001
NFKB p65 antibody
Rb pAb
Hu
GTX61185
NFKB p65 antibody [E379]
Rb mAb
Hu. Ms
NFkB p65 /
GTX50371
NFKB p65 antibody
Rb pAb
Hu . Ms. Rat
ICC/IF , IHC , WB
RelA
GTX27970
NFKB p65 antibody
Rb pAb
Hu , Ms , Rat
IHC-P , IP , WB
NFKB p65 antibody [112A1021]
Ms mAb
Hu , Ms , Cow , Mk , P 旬 , Rat
NFKB p65 (phospho Thr254) antibody
Rb pAb
Hu , Ms , Rat
ICC/IF , IHC , WB
þ GTX85622
NFKB p65 (phospho Ser276) antibody
Rb pAb
Hu , Ms , Rat
ELl SA.
Hu , Ms , Rat
IHC , WB
þ GTX78994
NFKB p65 (phospho Thr435) antibody
Rb pAb
Hu , Ms , Rat
ICC/IF , IHC , WB
Hu
þ GTX50254
NFKB p65 (phospho Ser529) antibody
Rb pAb
Hu . Ms. Rat
GTX102333
GTX61291
甸咱園
國 þ GTX78951
þ GTX50283
c-Rel
NFKB p65 (phospho Ser536) antibody
Rb pAb
Hu . Ms. Rat
Rel B antibody
Rb pAb
Hu. Ms
IKBa
甸甸園
園
ICC/IF , IHC , WB
Rel B (phospho Ser552) antibody
Rb pAb
Hu . Ms. Rat
IHC , WB
IHC , WB
ICC/IF , IHC-P , IP , WB
Rel B (phospho Ser573) antibody
Rb pAb
Hu , Ms
GTX62544
c-Rel antibody [EPR2558]
Rb mAb
Hu
ICC/IF , IHC-P , IP , WB
GTX74165
c-Rel antibody
Rb pAb
Hu
ELl SA , GSA , IP , WB
IKBa antibody
GTX61054
IKB口 antibody
GTX50468
IKB口 antibody
GTX12134
IKB口 antibody
47 -
一 -NF-kB
p105 /50
I ' -p50
47
[6A920]
NFkB pl05/p50 antibody (GTXII0585):
ICC /l F analysis of PFA-fixed HeLa
cells
NFkB pl05/p50 antibody (GTX50377):
WB analysis of HT29 cell Iysate using
j1)blocl呵帥t峙 preincubated and
2) un-incubated GTX50377
Rb pAb
Hu , Ms , Rat
ICC/IF , IHC , WB
Ms mAb
Hu . Ms
ICC/IF , WB
IP , WB
Rb pAb
Hu . Ms. Rat
ICC/IF , IHC , WB
咱國 þ GTX50681
IKB口 (phospho
Tyr42) antibody
Rb pAb
Hu . Ms. Rat
IHC , WB
ICC/IF , IP , WB
GTX63120
IKBß antibody [EPR5037]
Rb mAb
Hu
GTX27547
IKBß antibody
Rb pAb
Hu . Ms. Rat
GTX82797
IKBß antibody [7B4]
Ms mAb
Hu
IKBß (phospho Ser23) antibody
Rb pAb
Hu , Ms , Rat
GTX63006
IKBE antibody [EPR901 (2)]
Rb mAb
Hu
GTX50609
IKBE antibody
Rb pAb
Hu , Ms
IHC , WB
ICC/IF , IHC-P , IP , WB
ELl SA , IP , WB
ELl SA , ICCIIF , IHC
IHC-P
ICC / 悴 ,
IHC-P , IP , WB
IKBE (phospho Ser22) antibody
Rb pAb
Hu , Ms
IHC , WB
GTX59616
BcI-3 antibody
Rb pAb
Hu , Ms , Rat
IHC , IP
GTX15046
BcI-3 antibody [Ham150-3.5]
Hm mAb
Hu , Ms
KDa
A
B C
D
75
50
37 一
KDa
ELl SA , WB
A B C D
55 一 1-IBCL-3
75 一
50
37
11
35 一
ii16
I
32 一
I
26
(GTX l1 0521):
WB analysis of celllysates. A)
B) C2C12
IKBαantibody
BCL斗,
IKB 戶 antibody (EPR5037] (GTX63120):
WB analysis of cell Iysates. A) Jurkat;
B) HeLa; C) THP-1; D) MCF-7
IKBE antibody (EPR9 01(2)] (GTX63006):
WB analysis of celllysates. A) THP-1;
B) Jurkat; C) HeLa; D) A375
BcI -3 antibody (GTX59616):
WB analysis of Jurkat celllysate
(kD)
NFkB p65 (phospho Ser536) antibody
(GTX50098):
WB analysis of (1) untreated and
(2) TNF-treated HepG2 cells
NFKB p105/p50 antibody (GTX110585)
NFKB p50 antibody (GTX27549)
Koya , T. et al. (2012) Am J Physiol Heart Circ
Physio l. 303:H96-105
Adrianto , 1. el al. (2011) Nat Genet. 43:253-8. (EMSA)
可
Re lB antibody (GTX102333):
IHC-P analysis of HeLa xenograft
IKK family
|KK口 antibody
[Y 463]
、L
Hu , Ms , Rat
FACS , ICCIIF , IHC-P , IP , WB
IHC , WB
IKKa antibody
Rb pAb
Hu , Ms , Rat
|KKa antibody [14A231]
Ms mAb
Hu , Ms
|KKa (phospho Thr23) antibody
Rb pAb
Hu , Ms , Rat
Rb pAb
Hu , Ms
IKK口 (phospho
大代
Accelerated Discovery
ICC/IF , IHC-P , IP , WB
Ser32/Ser36) antibody
KDa
AB
130
9572-
IKK口
Our Antibodies
Hu , Ms , Rat
IKB口 (phospho
一一~
Application Reference
Your Expertise
Hu , Ms
Rb mAb
þ GTX50209
34
26 一
26
(kD)
Rb pAb
Hu
Bcl-3
NFkB-p65
(pSer536)
且噩噩噩個
自調呵呵?
Rb mAb
43
36-
36-
c-Rel antibody [EPR25581 (GTX62544):
WB analysis of cell Iysate. A) Daudi;
B) HuT-78; C) K562
Ser32) antibody [EPR3148]
甸園 þ GTX50252
1 2
R閱單單旭正圈,
[E130]
55-
85
NFKB p65 antibody (GTX I02090):
IHC-P analysis of A549 xenograft
IKB口 (phospho
IKBE
IHC-P , WB
Hu
118 一
25 一
由相繭ll"ill1I:J
GTX110521
咱國 þ GTX50317
ICC/IF , IHC , WB
Rb mAb
11885
37 一
• ' -NF-kB p52
þ GTX62342
IKBß
IHC , WB
Rel B antibody [EP613Y]
1 2
50-
NFkB p100/p52 antibody (GTX50610):
WB analysis of HT29 cell Iysate using
(1) blocking peptide-preincubated and
(2) un-incubated GTX50610
區D lH!l.
WB
Rb pAb
þ GTX50098
RelB
IHC干 ,
NFKB p65 (phospho Ser311) antibody
Rb pAb
47.5(kD)
Re lB (phospho Ser573) antibody
(GTX50283):
WB analysis of (1) untreated and
(2) TNF-treated HUVEC cells
FACS , IHC-P , WB
þ GTX78995
NFKB p65 (phospho Thr505) antibody
26 一
ICC/IF , IHC-P , WB
FACS , ICCIIF , IHC-P , IP , WB
甸園 þ GTX50097
þ GTX50219
62
IKB family
GTX102090
GTX13594
36(kD)
þ GTX50324
前2 甸唱園
團 þ GTX79000
NF-kB p100
83
IHC-P , WB
甸甸園
園 þ GTX78998
NFkB p100/
175
NRelB
(pSer573)
ICC/IF , IHC-P , WB
IHC , WB
KDa
250
15010075-
1 2
1 2
11885-
Ser176/Ser180) antibody
IP , WB
IHC , WB
WB
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