Michele Mari CV New Version - Università degli Studi di Urbino

Curriculum Vitae
Personal information
First name / Surname Michele Mari
Address
Telephones
E-mail
Nationality
Date of birth
Gender
Via delle querce n.19, 61049, Urbania (PU), ITALY
Laboratory: +39-0722-303328
Mobile: +39-380-52-06-201
Office: [email protected]
Personal: [email protected]
Italian
01 August 1986
Male
About Me
I am an Organic / Medicinal Chemistry Postdoctoral Fellow currently working in the field of
Synthesis of biologically active indole-containing molecules. In particular Total Synthesis of
Natural Products, mainly Indole-containig alkaloids such as Indolactam V, Clavicipitic Acid,
Aurantioclavine and Lysergic Acid, new methods for the synthesis of Bis-indoles and
catalytic Indole Reactivity, Dehydroalanine Reactivity and Applications, Protein and Peptide
Chemistry.
Work Experience
Dates
Occupation or position held
Main activities and responsibilities
Name and address of employer
Type of business or sector
11/2014 – Present
Postdoctoral Fellow
Catalytic functionalization of indoles and sustainable synthesis of chiral indole-based
alkaloids. Design, synthesis, optimization and characterization of biologically active
compounds.
Università degli Studi di Urbino “Carlo Bo”, Piazza Rinascimento 6, 61029 Urbino (PU), Italy
Department of Biomolecular Sciences, Section of Bio-Organic and Pharmaceutical Chemistry
(supervisor: Prof. Giovanni Piersanti)
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Education
Dates
Title of qualification awarded
Project
11/2011 – 12/2014
PhD in Medicinal Chemistry
Synthesis of Indole-containing biologically active molecules, total synthesis of several indolecontaining alkaloids and analogues with biological activity, synthesis of Bis-Indoles. Proteins
and Peptides Chemistry.
Principal subjects/occupational
skills covered
-Synthesis, purification and characterization of biologically active compounds
-Total synthesis of natural products
-Solid phase peptide synthesis, peptide purification and peptide ligations for the synthesis of
proteins
-Supervisor for master’s degree students
Name and type of organisation
providing education and training
Università degli Studi di Urbino “Carlo Bo”, Piazza Rinascimento 6, 61029 Urbino (PU), Italy
ETH Zurich, HCI Building, Vladimir-Prelog-Weg 3, CH-8093, Zurich, Switzerland (Visiting
PhD Student from 06/2013 to 02/2014 in Prof. Jeffrey W. Bode Group)
Dates
Title of qualification awarded
Name and type of organisation
providing education and training
12/2005 – 10/2011
First Class Honors Master’s Degree (110/110 cum laude) in Medicinal Chemistry and
Technology
Achieved the qualification to practice as pharmacist in Italy
Università degli Studi di Urbino “Carlo Bo”, Piazza Rinascimento 6, 61029 Urbino (PU), Italy
Awards / Fellowships
Dates
Fellowship
Organisation Issuing the Fellowship
Dates
Fellowship
Organisation Issuing the Fellowship
11/2011 – 10/2014
Merit fellowship covering the entire duration of the Ph.D. course (3 years)
Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR), Rome, Italy
12/2005 – 04/2011
Merit fellowship covering the tuitions/materials for the entire duration of the master’s degree
course
ERSU Urbino, Via V. Veneto 43-45, 61029 Urbino (PU), Italy
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Personal skills and
competences
Mother tongue
Other language
English
Social skills and competences
Organisational skills and
competences
Italian
Understanding
Speaking
Listening
Reading
Spoken interaction
Spoken production
Very Good
Excellent
Very Good
Very Good
Writing
Very Good
Due to my academic experience, I have developed good communication skills, stress
tolerance and the ability to work both in a team and autonomously. I've also developed
effectiveness in public presentations.
Good organizational skills, attention to details and ability to meet deadlines.
Technical skills and competences
Experience with:
- Compound synthesis: mainly classical synthesis (in solution) and microwave synthesis
- Solid Phase Peptide Synthesis (manual and automatical using peptide synthesizers)
- Compound purification: chromatography, extraction, distillation and crystallization
- Compound characterization: TLC, HPLC, LC-MS, GC-MS, IR, NMR, polarimetry, MALDITOF.
- Use of the most common databases, such as SciFinder, Scopus and Web of Science.
Computer skills and competences
Experience with Computer Software: Microsoft Office Word, Excel, Powerpoint, Outlook;
Cambridgesoft ChemDraw; Chemical databases (SciFinder, Uniprot); software for the
elaboration of chromatograms / spectra (Mestrenova).
Driving licence
Interests
Italian Driving License (Car)
I am mainly interested in:
- Music (I’ve been studying vocal techniques and singing for 5 years, leading a band, many
concerts and studio experiences)
- Sports (soccer, basketball, tennis)
- Photography
- Travelling
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Additional information
Pubblications
- Spadoni, G.; Bedini, A.; Lucarini, S.; Mari, M.; Caignard, D.-H.; Boutin, J.; Delagrange, P.;
Lucini, V.; Scaglione, F.; Lodola, A.; Zanardi, F.; Pala, D.; Mor, M.; Rivara, S. “Highly potent
and selective MT2 melatonin receptor full agonists from conformational analysis of 1-benzyl2-acylaminomethyl-tetrahydroquinolines”. J. Med. Chem. 2015, 58, 7512-7525.
- Bartolucci, S.; Mari, M.; Bedini, A.; Piersanti, G.; Spadoni, G. “Iridium-Catalyzed Direct
Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols
as Alkylating Agents”. J. Org. Chem. 2015, 80, 3217-3222.
- Mari, M.; Lucarini, S.; Bartoccini, F.; Piersanti, G.; Spadoni, G. “Synthesis of 2-Substituted
Tryptophans via a C3- to C2-Alkyl Migration”. Beilstein J. Org. Chem. 2014, 10, 1991-1998.
- Mari, M.; Tassoni, A.; Lucarini, S.; Fanelli, M.; Piersanti, G.; Spadoni, G. “Brønsted Acid
Catalyzed Bisindolization of α-Amido Acetals: Synthesis and Anti-cancer Activity of
Bis(indolyl)ethanamino Derivatives”. Eur. J. Org. Chem. 2014, 18, 3822-3830.
- Bartoccini, F.; Casoli, M.; Mari, M.; Piersanti, G. “Synthesis of (±)-cis-Clavicipitic Acid by a
Rh(I)-Catalyzed Intramolecular Imine Reaction”. J. Org. Chem. 2014, 79, 3255-3259.
- Lucarini, S.; Mari, M.; Piersanti, G.; Spadoni, G. “Organocatalyzed coupling of indoles with
dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates”. RSC Adv.
2013, 3, 19135-19143.
- Mari, M.; Bartoccini, F.; Piersanti G. “Synthesis of (-) epi-Indolactam V by an
intramolecular Buchwald-Hartwig C-N Coupling Cyclization Reaction”. J. Org. Chem. 2013,
78, 7727-7734.
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Participation in Meetings
- European School of Medicinal Chemistry, 35th Edition (28 June - 3 July 2015, Urbino,
ITALY)
- XIV Sigma-Aldrich Young Chemists Symposium (27-29 October 2014, Riccione, ITALY);
oral presentation entitled: “Iridium-Catalyzed Hydrogen Transfer: Direct Synthesis of
Tryptamines from Indoles”
- European School of Medicinal Chemistry, 34th Edition (29 June - 4 July 2014, Urbino,
ITALY); poster and selected oral presentation entitled: “Strategic Indole and Tryptophan
functionlization for the synthesis of Natural Products and Biologically Active Compounds”
- XXXIX “A. Corbella” International Summer School on Organic Synthesis ISOS (15-19 June
2014, Gargnano, ITALY); oral and poster presentation entitled: “Synthesis of 2-alkylated
tryptophans by Friedel-Crafts alkylation of 3-alkylindoles with Dehydroalanine dervatives”
- Senn Chemicals 50th Anniversary Symposium (29 August 2013, Zurich, SWITZERLAND)
- XII Sigma-Aldrich Young Chemists Symposium (1-3 October 2012, Riccione, ITALY);
oral presentation entitled: “Concise Synthesis of Indole Alkaloid (-)-Indolactam V via
Intramolecular Buchwald-Hartwig Amination”
- European School of Medicinal Chemistry, 32nd Edition (2-7 July 2012, Urbino, ITALY)
- Boron Neutron Capture Therapy in Pavia: state of the art and perspectives
in the light of CARIPLO research projects (28 May 2012, Pavia, ITALY)
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