4-Hyrdroxy-DIPT

4-Hydroxy-DIPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
CH3
H3C
OH
CH3
N
CH3
N
H
1. GENERAL INFORMATION
IUPAC Name:
3-[2-(diisopropylamino)ethyl]-1H-indol-4-ol
CAS#:
63065-90-7
Synonyms:
4-OH-DIPT, 4-HO-DIPT, iprocin, 4-hydroxy-N,N-diisopropyltryptamine
Source:
DEA Reference Material Collection
Appearance:
White powder
UVmax (nm):
Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form
Chemical Formula
Molecular Weight
Melting Point ( oC)
Base
C16H24N2O
260
Not Determined
HCl
C16H24N2O . HCl
296
283.2
Latest Revision: 1/5/2015
SWGDRUG.org/monographs.htm
Page 1 of 5
4-Hydroxy-DIPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in base extracted CDCl3 containing TMS for 0 ppm
reference.
Instrument:
400 MHz NMR spectrometer
Parameters:
Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1
H NMR: 4-OH DIPT HCl Lot SF06008; CDCl3; 400MHz
TMS
10
9
8
7
CHCl3
6
5
4
3
2
1
0
1 2
1
22 2
7
6
5
4
12
3
2
1
0
0.75
0.50
0.25
0
1
2
7.00
Latest Revision: 1/5/2015
1
6.75
2
3.1
2
3.0
SWGDRUG.org/monographs.htm
12
2
2.9
2.8
1.050
1.000
Page 2 of 5
4-Hydroxy-DIPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL methanol.
Instrument:
Column:
Carrier Gas:
Temperatures:
Agilent gas chromatograph operated in split mode with MS detector
DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µm
Helium at 1 mL/min
Injector: 280oC
MSD transfer line: 280oC
MS Source: 230 oC
MS Quad: 150oC
Oven program:
1) 100oC initial temperature for 1.0 min
2) Ramp to 300 oC at 12 oC/min
3) Hold final temperature for 9.0 min
Split Ratio = 20:1, 1 µL injected
Mass scan range: 30-550 amu
Threshold: 100
Tune file: stune.u
Acquisition mode: scan
14.502 min
EI Mass Spectrum: 4-OH-DIPT HCl Lot # SF06008
Injection Parameters:
MS Parameters:
5
Intensity [x 10 ]
114
Retention Time:
1.5
40
80
Latest Revision: 1/5/2015
100
120
140
160
180
SWGDRUG.org/monographs.htm
200
220
240
260
245
229
215
199
174
160
130
104
86
91
146
60
77
65
EI+
56
43
0.5
30
72
1.0
260
m/z
Page 3 of 5
4-Hydroxy-DIPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument:
Scan Parameters:
FTIR with diamond ATR attachment (1 bounce)
Number of scans: 32
Number of background scans: 32
Resolution: 4 cm-1
Sample gain: 8
Aperture: 150
735
40
490
582
661
50
843
968
1038
1130
1161
1261
1294 1350
60
1396
1433
1452
1589
3147
2669
3240
70
2943
%Transmittance
FTIR ATR (Diamond, 1 Bounce): 4-OH-DIPT HCl Lot SF06008
30
20
3000
1500
Wavenumber (cm-1)
490
517
582
604
634
661
694
756
785
843
968
1049
1038
1261
50
2000
1093
1130
1161
60
2500
1294
1319
1350
70
1396
1433
1452
1589
1506
%Transmittance
3500
735
40
30
20
1700
1600
1500
Latest Revision: 1/5/2015
1400
1300
1200
1100
1000
SWGDRUG.org/monographs.htm
900
800
700 Wavenumber (cm-1)
Page 4 of 5
4-Hydroxy-DIPT
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
4. ADDITIONAL RESOURCES
Forendex
http://forendex.southernforensic.org/index.php/detail/index/1175
Wikipedia
http://en.wikipedia.org/wiki/4-HO-DiPT
Latest Revision: 1/5/2015
SWGDRUG.org/monographs.htm
Page 5 of 5