Karin Moelling LIST OF PUBLICATIONS

Transcription

Karin Moelling
25.09.2010
LIST OF PUBLICATIONS
KARIN MOELLING
1.
Moelling, K., Bolognesi, D.P. and Bauer, H. Polypeptides of avian RNA tumor viruses. III. Purification and
identification of a DNA synthesizing enzyme. Virology 45, 298-302 (1971).
2.
***Moelling, K.,
Bolognesi, D.P., Bauer, H., Büsen, W., Plassmann, H.W. and Hausen, P. Association of
the viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. Nature New
Biology 234, 240-243 (1971) Comparative Leukemia Research, Bibl. Haematol. 39, 536-550 (1973).
And in: "Selected Papers in Tumor Virology". Eds. J. Tooze, J. Sambrook. Cold Spring Harbor Press,
pp. 815-818 (1974).
3.
Bolognesi, D.P., Gelderblom, H., Bauer, H., Moelling, K. and Hüper, G. Polypeptides of avian RNA tumor
viruses. V. Analysis of the Virus Core. Virology 47, 567-578 (1972).
4.
Bauer, H., Bolognesi, D.P., Gelderblom, H., Graf, T., Kurth, R. and Moelling, K. Hühner RNS Tumorviren:
Ein Modell für virusbedingte Cancerogenese. Zbl. Bakteriol. I. Abt. Orig. A 220, 66-78 (1972).
5.
Bolognesi, D.P., Bauer, H., Gelderblom, H. and Moelling, K. Structural components of avian myeloblastosis
virus. Comparative Leukemia Res., Bibl. Haematol. 39, 316-330 (1973).
6.
*Watson, K.F., Moelling, K. and Bauer, H. RNase H activity present in purified DNA polymerase from AMV.
Biochem. Biophys. Res. Comm. 51, 232-240 (1973).
7.
Bauer, H., Daams, J.H., Watson, K.F., Moelling, K., Gelderblom, H., and Schäfer, W. Oncornavirus-like
particles in HeLa cells. II. immunological characterization of the virus. Int. J. Cancer 13, 254-261 (1974).
8.
Gelderblom, H., Ogura, H., Moelling, K., Watson, K.F. and Bauer, H. Weitere Charakterisierung des HeLa
Virus. Zbl. Bakt. Hyg. I. Abt. Orig. A 227, 426-434 (1974).
9.
Watson, K.F., Moelling, K., Gelderblom, H. and Bauer, H. Oncorna virus-like particles in HeLa cells. III.
Biochemical characterization of the virus. Int. Journ. of Cancer 13, 262-267 (1974).
10.
***Moelling, K. Reverse transcriptase and RNase H: Present in a murine virus and in both subunits of an
avian virus. Cold Spring Harbor Symp. Quant. Biol. 39, 969-973 (1974a).
11. Moelling, K.: Characterization of Reverse Transcriptase and RNase H from Friend murine leukemia virus.
Virology 62, 46-59 (1974b).
12. Moelling, K., Gelderblom, H., Pauli, G., Friis, R.R. and Bauer, H. A comparative study of the avian
reticuloendo-theliosis virus: Relationship to murine leukemia virus and viruses of the avian sarcoma-leukosis
complex. Virology 65, 546-557 (1975).
13.
*Moelling, K. Further characterization of the Friend murine leukemia virus RNase H complex. J. Virol. 18,
418-425 (1976).
14.
**Moelling, K. Exciting days over for reverse transcriptase? Nature 256, 258-260 (1975).
15. Moelling, K. Comparison between an avian and a murine viral reverse transcriptase RNase H complex.
Comparative Leukemia Res., Bibl. Haematol. 43, 121-124 (1976).
16.
**Moelling, K. Anything new about reverse transcriptase? Nature 264, 111-112 (1976).
17. Moelling, K. Ribonuclease H of viral and cellular origin. Chapter for Recent Advances in Cancer Research,
Ed. R.C. Gallo, CRC-Press, Cleveland, pp. 121-136 (1977).
18. Moelling, K. and Hayami, M. Analysis of precursors to the envelope glycoproteins of avian RNA tumor
viruses in chicken and quail cells. J. Virol. 22, 598-607 (1977).
19. Moelling, K. Immunological characterization of the RNA-dependent
reticuloendotheliosis virus. Med. Microbiol. Immunol. 164, 115-118 (1977).
DNA
polymerase
from
20. Dittmar, K.J. and Moelling, K. Biochemical properties of p15-associated protease in an avian RNA tumor
virus. J. Virol. 28, 106-118 (1978).
21. Moelling, K., Sykora, K.W., Dittmar, K.E.J., Scott, A. and Watson, K.F. The isolation of avian viral RNA and
polypeptides. J. Biol. Chem. 254, 3738-3742 (1979).
*** / ** / * Grading of Importance
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22. Novak, U., Friedrich, R. and Moelling, K. Elongation of DNA complementary to the 5' end of the avian
sarcoma virus genome by the virion-associated RNA-dependent DNA polymerase. J. Virol. 30, 438-452
(1979).
23. Friedrich, R. and Moelling, K. Effect of viral RNase H on the avian sarcoma viral genome during early
transcription in vitro. J. Virol. 31, 630-638 (1979).
24. Moelling, K. and Friis, R.R. Two avian sarcoma virus mutants with defects in the DNA polymerase-RNase H
complex. J. Virol. 32, 370-378 (1979).
25. Owada, M., Donner, P., Dittmar, K.E.J. and Moelling, K. Comparison of protein kinase activities in normal
cells and cells transformed by a temperature-sensitive mutant of avian sarcoma virus to those of cell-free
viral translation products. Cold Spring Harbor Symp. Quant. Biol. 44, 959-965 (1980).
26. Moelling, K., Scott, A., Dittmar, K.E.J. and Owada, M. Effect of p15-associated protease from an avian RNA
tumor virus on avian virus-specific polyprotein precursors. J. Virol. 33, 680-688 (1980).
27. Owada, M. and Moelling, K.: Temperature-sensitive kinase activity associated with various mutants of avian
sarcoma viruses which are temperature sensitive for transformation. Virology 101, 157-168 (1980).
28. Bunte, T., Novak, U., Friedrich, R. and Moelling, K. Effect of actinomycin D on nucleic acid hybridization.
The cause of erroneous DNA elongation during DNA synthesis of RNA tumor viruses in vitro.
Biochim. Biophys. Acta 610, 241-247 (1980).
29. Dittmar, K.E.J., Brauer, D. and Moelling, K. Polyprotein processing by avian viral protease. In:
"Biosynthesis Modifications and Processing of Cellular and Viral Polyproteins". Eds. G. Koch, D. Richter.
Academic Press, New York, pp. 289-299 (1980).
30. Owada, M.K., Donner, P., Scott, A. and Moelling, K. Isolation of an avian sarcoma virus-specific protein
kinase from virus particles. Virology 110, 333-343 (1981).
src
31. Donner, P., Bunte, T., Owada, M.K. and Moelling, K. Biochemical characterization of pp60 -associated
protein kinase from avian sarcoma virus Schmidt-Ruppin strain. J. Biol. Chem. 256, 8786-8794 (1981).
32. Sykora, K.W. and Moelling, K. Properties of the avian viral protein p12. J. Gen. Virol. 55, 379-391 (1981).
src
33. Moelling, K., Owada, M.K., Donner, P. and Bunte, T. The transformation-specific protein pp60
from an
avian sarcoma virus. In: Haematology and Blood Transfusion, Vol. 26. "Modern Trends in Human Leukemia
IV". Eds. R. Neth, R.C. Gallo, T. Graf, Mannweiler, Winkler. Springer-Verlag, Berlin-Heidelberg, pp. 405-408
(1981).
34. Bunte, T., Owada, M.K., Donner, P., Boschek, C.B. and Moelling, K.1 Association of the transformationspecific protein pp60src with the membrane of an avian sarcoma virus. J. Virol. 38, 1034-1047 (1981).
35. Greiser-Wilke, I., Owada, K.M. and Moelling, K. Isolation of monoclonal antibodies against avian
oncornaviral protein p19. J. Virol. 39, 325-329 (1981).
36.
***Donner, P., Greiser-Wilke, I. and Moelling, K.2 Nuclear localization and DNA-binding of the transforming
gene product of avian myelocytomatosis virus. Nature 296, 262-266 (1982).
37.
*Bunte, T.,
Greiser-Wilke, I., Donner, P. and Moelling, K. Association of gag-myc proteins from avian
myelocytomatosis virus wild-type and mutants with chromatin. EMBO J. 1, 919-927 (1982).
38. Bunte, T. and Moelling, K. Analysis of two phosphoproteins related to pp60
particles. J. Gen. Virol. 64, 723-726 (1983).
src
from Schmidt-Ruppin D virus
39. Moelling, K., Owada, M.K., Greiser-Wilke, I., Bunte, T. and Donner, P. Biochemical characterization of
transformation-specific proteins of acute avian leukemia and sarcoma viruses. J. Cell. Biochem. 20, 63-69
(1982).
40. Moelling, K., Greiser-Wilke, I., Owada, M.K., Donner, P. and Bunte, T. DNA-binding ability of transforming
proteins from avian erythroblastosis virus and mutant avian myelocytomatosis virus, MC29, in comparison
with MC29 wild type. In: Haematology and Blood Transfusion, Vol. 28, "Modern Trends in Human Leukemia
V", Eds. Neth, Gallo, Greaves, Moore, Winkler. Springer-Verlag, Berlin-Heidelberg, pp. 214-217 (1983).
1
Für diese Arbeit erhielten T. Bunte und K. Moelling den Vincenz-Czerny-Preis für Onkologie, 1981.
2
Für diese Arbeit erhielt K. Moelling den Preis der Walther und Christiane Richtzenhain-Stiftung 1982 zum Thema "Mechanismen der
Krebsentstehung".
*, **, *** grading of improtance
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41. Steinheider, G., Greiser-Wilke, I., Hauser, H., Bumke-Vogt, C., Moelling, K. and Graessmann, A. DNAmediated gene transfer in Friend leukemia cells by cotransfection of Simian Virus 40 DNA with Herpes
simplex virus thymidine kinase DNA. J. Virol. 45, 375-382 (1983).
42.
***Donner, P.,
43.
*Bunte, T., Greiser-Wilke, I. and Moelling, K. The transforming protein of the MC29-related virus CMII is a
Bunte, T., Greiser-Wilke, I. and Moelling, K. Decreased DNA-binding ability of purified
transformation-specific proteins from deletion mutants of the acute avian leukemia virus MC29. Proc. Natl.
Acad. Sci. USA 80, 2861-2865 (1983).
nuclear DNA-binding protein whereas MH2 codes for a cyto-plasmic RNA-DNA binding polyprotein. EMBO
J. 2, 1087-1092 (1983).
44. Moelling, K. Molecular mechanisms of malignant transformation by oncornaviruses. In: "Mechanisms of
B Cell Neoplasia". Eds. F. Melchers, M. Potter, M. Weigert, Edition Roche, Basel, pp. 307-316 (1983).
45. Moelling, K., Donner, P., Bunte, T. and Greiser-Wilke, I. Molecular mechanisms of malignant transformation
by oncornaviruses. In: "Contributions to Oncology", Vol. 19, "Genes and Antigens in Cancer Cells - The
Monoclonal Antibody Approach". Eds. G. Riethmüller, H. Koprowski, S. von Kleist, K. Munk. Karger, Basel,
pp. 35-43 (1984).
46. *Bunte, T., Donner, P., Pfaff, E., Reis, B., Greiser-Wilke, I., Schaller, H. and Moelling, K. Inhibition of DNA
binding of purified p55v-myc in vitro by antibodies against bacterially expressed myc protein and a synthetic
peptide. EMBO J. 3, 1919-1924 (1984).
47. Moelling, K., Benter, T., Bunte, T., Pfaff, E., Deppert, W., Egly, J.M. and Miyamoto, N.B. Properties of the
myc-gene product: Nuclear association, inhibition of transcription and activation in stimulated lymphocytes.
Curr. Top. Microbiol. Immunol. 113, 198-207 (1984).
48. Moelling, K., Bunte, T., Greiser-Wilke, I., Donner, P. and Pfaff, E. Properties of the avian viral transforming
proteins gag-myc, myc, and gag-mil. In: "Cancer Cells, Vol. 2, Oncogenes and Viral Genes", Eds.
G.F. van de Woude, A.J. Levine, W.C. Topp, J.D. Watsons. Cold Spring Harbor Laboratory, pp. 173-180
(1984).
49.
***Moelling, K.,
Heimann, B., Beimling, P., Rapp, U.R. and Sander, T.: Serine- and threonine-specific
protein kinase activities of purified gag-mil and gag-raf proteins. Nature 312, 558-561 (1984).
50. Moelling, K.: Fusion proteins in retroviral transformation. In: "Advances in Cancer Research", Vol. 43. Eds.
G. Klein, S. Weinhouse, Academic Press, New York, pp. 205-239 (1985).
51.
**Moelling, K., Pfaff, E., Beug, H., Beimling, P., Bunte, T., Schaller, H.E. and Graf, T. DNA-binding activity
is associated with purified myb proteins from AMV and E26 viruses and is temperature-sensitive for E26 ts
mutants. Cell 40, 983-990 (1985).
52. Kurth, R., Tanaka, T. and Moelling, K. Isolation of monoclonal antibodies specific for Rous Sarcoma Virus
structural, polymerase and transforming proteins and their use for the study of mutant virus-infected cells. J.
Gen. Virol. 66, 827-837 (1985).
53. Benter, T., Beimling, P., Pfaff, E., Sander, T., Heimann, B. and Moelling, K. Identification of the human
cellular myc gene product by antibody against the bacterially expressed protein. In: Haematology and Blood
Transfusion, Vol. 29. "Modern Trends in Human Leukemia VI", Eds. R. Neth, R.C. Gallo, M.F. Greaves,
R. Janka. Springer-Verlag, Berlin-Heidelberg, pp. 266-268 (1985).
54. Heimann, B., Beimling, P., Pfaff, E., Schaller, H. and Moelling, K. Analysis of a tyrosine-specific protein
kinase activity associated with the retroviral erbB oncogene product. Exp. Cell Res. 161, 199-208 (1985).
55. Beimling, P., Benter, T., Sander, T. and Moelling, K. Isolation and characterization of the human cellular
myc gene product. Biochemistry 24, 6349-6355 (1985).
56. Rapp, U.R., Bonner, T.I., Moelling, K., Jansen, H.W., Bister, K. and Ihle, J.: Genes and gene products
involved in growth regulation of tumor cells. In: "Recent Results in Cancer Research" Vol. 99. Eds.
K. Havemann, G. Sorenson, C. Gropp. Springer-Verlag, Berlin-Heidelberg-New York, pp. 221-236 (1985).
57. Moelling, K., Sander, T., Lorenz, U., Beimling, P. and Bading, H. Interaction of the oncogene protein myc
with specific DNA fragments. J. Cancer Res. Clin. Oncol. 112, 97-99 (1986).
58. Moelling, K. Properties of the myc and myb gene products. In: "Oncogenes and Growth Control", Eds.
P. Kahn, T. Graf. Springer-Verlag, Berlin-Heidelberg, pp. 271-277 (1986).
59. Moelling, K., Lorenz, U., Beimling, P., Heimann, B., Thomas, G., Bading, H. and Sander, T. Biochemical
properties of oncogene-coded proteins. In: "Cell Cycle and Oncogenes", Springer-Verlag, Berlin-Heidelberg,
pp. 105-113 (1986).
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60. Moelling, K., Heimann, B., Beimling, P., Bepler, G., Köppler, H., Havemann, K. and Balzer, T. Analysis of
oncogene proteins in human cell tumor lines. In: "Contributions to Oncology", Eds. S. Eckhards,
J.W. Holzner, G. Nagel, Vol. 24. Eds. P.H. Hofschneider, K. Munk. Karger, Basel, pp. 76-86 (1987).
61.
**Hansen, J., Schulze, T. and Moelling, K. RNase H activity associated with bacterially expressed reverse
transcriptase of human T-cell lymphotropic virus III/lymphadenopathy-associated virus. J. Biol. Chem. 262,
12393-12396 (1987).
62. Bading, H., Hansen, J. and Moelling, K. Selective DNA binding of the human cellular myb protein isolated
by immunoaffinity chromatography using a monoclonal antibody. Oncogene 1, 395-401 (1987).
63. Moelling, K., Heimann, B., Bading, H., Häder, M., Bepler, G., Havemann, K. and Beutler, C. Proteins of
oncogenes in human tumor cells. In: "Modulation of Liver Cell Expression", Eds. W. Reutter, H. Popper,
I.M. Arias, P.C. Heinrich, D. Keppler, L. Landmann. MTP Press Ltd., Lancaster, England, pp. 275-285
(1987).
64. Bading, H., Beutler, C., Beimling, P., Gerdes, J., Stein, H. and Moelling, K. Monoclonal antibodies against
the viral and human cellular myb-gene product. In: Haematology and Blood Transfusion, Vol. 31. "Modern
Trends in Human Leukemia VII", Eds. R. Neth, R.C. Gallo, M.F. Greaves, H. Kabisch. Springer-Verlag,
Berlin-Heidelberg, pp. 488-492 (1987).
65. Reinwald, E., Greiser-Wilke, I., Artama, W., Risse, H.-J. and Moelling, K. Characterization of epitopes on a
variant surface glycoprotein from Trypanosoma congolense by six monoclonal antibodies. Eur. J.
Biochem. 167, 525-532 (1987).
66. Häder, M., Stach-Machado, D., Pflüger, K.-H., Rotsch, M., Heimann, B., Moelling, K. and Havemann, K.
Epidermal growth factor receptor expression, proliferation, and colony stimulating activity production in the
urinary bladder carcinoma cell line 5637. J. Cancer Res. Clin. Oncol. 113, 579-585 (1987).
67.
**Hansen, J.,
68.
**Denhez, F.,
69.
**Hansen, J., Billich, S., Schulze, T., Sukrow, S. and Moelling, K. Partial purification and substrate analysis
Schulze, T., Mellert, W. and Moelling, K. Identification and characterization of HIV-specific
RNase H by monoclonal antibody. EMBO J. 7, 239-243 (1988).
Heimann, B., d'Auriol, L., Graf, T., Coquillaud, M., Coll, J., Galibert, F., Moelling, K.,
Stehelin, D. and Ghysdael, J. Replacement of lys 622 in the ATP binding domain of P100gag-mil abolishes
the in vitro autophosphorylation of the protein and the biological properties of the v-mil oncogene of MH2
virus. EMBO J. 7, 541-546 (1988).
of bacterially expressed HIV protease by means of monoclonal antibody. EMBO J. 7, 1785-1791 (1988).
70. Moelling, K. Gene products and replication mechanism of HIV. In: "HIV and Nervous System", Eds. Kubicki,
Henkes, Bienzle, Pohle. Gustav Fischer, Stuttgart 1988, pp. 9-14 (1988).
71. Bading, H., Gerdes, J., Schwarting, R., Stein, H. and Moelling, K. Nuclear and cytoplasmic distribution of
cellular myb protein in human haematopoietic cells evidenced by monoclonal antibody. Oncogene 3, 257265 (1988).
72. Müller, R., Klempnauer, K.-H., Moelling, K., Beug, H. and Vennström, B. Cellular oncogenes encoding
nuclear proteins: fos, myb, myc and erbA. In: "Cellular Oncogene Activation". Ed. Klein, G., Marcel Dekker,
Inc., New York, Basel, pp. 1-54 (1988).
73. Billich, S., Knoop, M.T., Hansen, J., Strop, P., Sedlacek, J., Mertz, R. and Moelling, K. Synthetic peptides
as substrates and inhibitors of human immune deficiency virus-1 protease. J. Biol. Chem. 263, 17905-17908
(1988).
74. Denhez, F., Galibert, F., Heimann, B., Dozier, C., Graf, T., Moelling, K., Stehelin, D. and Ghysdael, J. An
invariant asparagine residue belonging to a highly conserved domain in all protein kinases is instrumental in
the protein kinase activity of the v-mil gene product. Oncogene Research 3, 199-205 (1988).
75. Biesert, L., Suhartono, H., Winkler, I., Meichsner, C., Helsberg, M., Hewlett, G., Klimetzek, V., Mölling, K.,
Schlumberger, H.-D., Schrinner, E., Brede, H.-D. and Rübsamen-Waigmann, H. Inhibition of HIV and virus
replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound. AIDS 2, 449-457 (1988).
76. Moelling, K. Onkogene und Zelldifferenzierung. Verh. Dtsch. Ges. für Path. 72,1-9 (1988).
77. Bazin, H., Chattopadhyaya, J., Datema, R., Ericson, A.-C., Gilljam, G., Johansson, N.G., Hansen, J.,
Koshida, R., Moelling, K., Öberg, B., Remaud, G., Stening, G., Vrang, L., Wahren, B. and Wu, J.C. An
analysis of the inhibition of replication of HIV and MULV by some 3'-blocked pyrimidine analogs.
Biochemical Pharmacology 38, 109-119 (1989).
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78. Bepler, G., Bading, H., Heimann, B., Kiefer, P, Havemann, K. and Moelling, K. Expression of p64c-myc and
neuroendocrine properties define three subclasses of small cell lung cancer. Oncogene 4, 45-50 (1989).
79. Bading, H., Beutler, C. and Moelling, K. Mapping of a small phosphopeptide at the carboxyterminus of the
viral myb protein by monoclonal antibodies. Oncogene 4, 33-38 (1989).
80.
*Beimling, P. and Moelling, K. Isolation and characterization of the tax-protein of HTLV-I. Oncogene 4, 511516 (1989).
81. Moelling, K. Replication of HIV, in "Colloque des Cent Gardes", on Retroviruses of human AIDS and related
animal diseases. Ed. by M. Girard, and L. Valette, Pasteur Vaccins, Paris, S. 100-107 (1989).
82. Bading, H., Rauterberg, E.W. and Moelling, K. Distribution of c-myc, c-myb, and Ki 67 antigen in interphase
and mitotic human cells evidenced by immunofluorescence staining technique. Experim. Cell Res. 185, 5059 (1989).
83. Moelling, K., Schulze, T. and Diringer, H. Inhibition of HIV-1 RNase H by sulfated polyanions. J. Virol. 63,
5489-5492 (1989).
84. Beimling, P. and Moelling, K. Tax-independent binding of multiple cellular factors to Tax-response element
DNA of HTLV-I. Oncogene 5, 361-368 (1990).
85.
*Kalkbrenner, F., Guehmann, S., and Moelling, K. Transcriptional activation by human c-myb and v-myb
genes.
86. Haeder, M., Rotsch, M., Bepler, G., Hennig, C., Havemann, K., Heimann, B. and Moelling, K. Epidermal
growth factor receptor expression in human lung cancer cell lines. Cancer Research 48, 1132-1136 (1988).
87. Moelling, K., Knoop, M.T., Billich, S., Blaha, J., Pavlickova, L. and Soucek, M. Characterization of HIV-1
protease substrate specificity by use of synthetic peptides. In: "Proteases and Retroviruses". Proceedings of
the 14th Int. Congress of Biochemistry, Ed. V. Kostka, W. de Gruyter and Co., Berlin, p.155-165 (1989).
88. Kalthoff, H., Röder, C., Schewe, K., Schmiegel, W., Thiele, H.-G., Heimann, B., Bading, H., Schramm, K.
and Moelling, K. Analysis of c-raf-oncogene expression in gastrointestinal tumor cells. In: Modern Trends in
Human Leukaemia, VIII, Ed. R. Neth, p. 436-439 (1989).
89. Bading, H., Gerdes, J., Schwarting, R., Stein, H. and Moelling, K. Distribution of the cellular myb protein in
human and haematopoietic cells as evidenced by monoclonal antibody. In: "LEUCOCYTE TYPING IV:
White Cell Differentiation Antigens" (B. Dörken, W. Gilks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.Kr. von
dem Borne, W. Knapp, eds.). Oxford University Press, p. 468-469 (1989).
90. Guenet, C., Leppik, R.A., Pelton, T., Moelling, K., Lovenberg, W. and Harris, B.A. HIV-1 protease:
mutagenesis of asparagine 88 indicates a domain required for dimer formation. Europ. J. of Pharmacol. 172,
443-451 (1989).
91. Bading, H. and Moelling, K. Transcriptional down-regulation of c-myc expression by protein synthesisdependent and -independent pathways in a human T-lymphoblastic tumor cell line. Cell Growth and
Differentiation 1, 113-117 (1990).
92. Moelling, K., Nawrath, M., Schulze, T., Pavlitzkova, L., Soucek, M., Budt, K.-H., Pearl, L., Knoop, M.-T.,
Kay, J. and Kruft, V. Cleavage of RT/RNase H by HIV-1 protease and analysis of substrate cleavage sites
in vitro. In: "RETROVIRAL PROTEASES: Control of Maturation and Morphogenesis". Ed. L.H. Pearl,
McMillan Publishers, p. 19-29 (1990).
93. Moelling, K., Schulze, T., Knoop, M.-T., Kay, J., Jupp, R., Nicolaou, G. and Pearl, L.H. In vitro inhibition of
HIV-1 proteinase by cerulenin. FEBS Letters 261, 373-377 (1990).
94. Schulze, T., Nawrath, M. and Moelling, K. Cleavage of the HIV-1 p66 reverse transcriptase/RNase H by the
p9 protease in vitro generates active p15 RNase H. Archives of Virol. 118, 179-188 (1991).
95. Tisdale, M., Schulze, T., Larder, B.A. and Moelling, K. Mutations within the RNase H domain of HIV-1
reverse transcriptase abolish virus infectivity. J. Gen. Virol. 72, 59-66 (1991).
96.
*Wöhrl,
B. and Moelling, K. Interaction of HIV-1 RNase H with polypurine tract containing RNA-DNA
hybrids. Biochem. 29, 10141-10147 (1990).
97. Lorenz, U., Sock, E., Grummt, F. and Moelling, K. Analysis of DNA sequences present in complexes of vMyc and cellular DNA. Oncogene 6, 51-57 (1991).
98. Krohn, K.J.E., Ovod, V., Lagerstedt, A., Saarialho-Kere, U., Gombert, F.O., Jung, G., Moelling, K. and
Ranki, A. Expression kinetics and cellular localization of HIV tat and nef proteins in relation to the expression
of viral structural mRNA and viral particles. Vaccines, Cold Spring Harbor Laboratory (1991).
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99. Zobel, A., Kalkbrenner, F., Guehmann, S., Nawrath, M., Vorbrueggen, G. and Moelling, K. Interaction of the
v- and c-Myb proteins with regulatory sequences of the human c-myc gene: Oncogene 6, 1397-1407 (1991).
100.
**Wöhrl, B., Volkmann, S. and Moelling, K. Mutations of a conserved residue within HIV-1 ribonuclease H
affect its exo- and endonuclease activities. J. Mol. Biol. 220, 801-818 (1991).
101. Lorenz, U., Beimling, P., Cao, J. and Moelling, K. Analysis of human retroviral regulatory proteins Tax and
Tat. In: Modern Trends in Human Leukaemia IX: Haematology and Blood Transfusion Vol. 35 (R. Neth et.
al., Eds.) Springer Verlag Berlin Heidelberg, p. 235-240 (1992).
102. *Beimling, P. and Moelling, K. Direct interaction of CREB protein with 21 bp Tax-response elements of
HTLV-1 LTR. Oncogene 7, 257-262 (1992).
103. Bouwmeester, T., Guehmann, S., El-Baradi, T., Kalkbrenner, F., van Wijk, I., Moelling, K. and Pieler, T.
Molecular cloning, expression and in vitro functional characterization of myb-related proteins in Xenopus.
Mech. of Developm. 37, 57-68 (1992).
104. Zobel, A., Kalkbrenner, F., Vorbrueggen, G. and Moelling, K. Transactivation of the human c-myc gene by
c-Myb. Biochem. Biophys. Res. Commun. 186, 715-722 (1992).
105. *Guehmann, S., Vorbrueggen, G, Kalkbrenner, F. and Moelling, K. Reduction of a conserved cys is
essential for Myb-DNA binding. Nucl. Acid Res. 20, 2279-2286 (1992).
106. *Volkmann, S., Wöhrl, B.M., Tisdale, M. and Moelling, K. Enzymatic analysis of two HIV-1 reverse
transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral
ribonucleases H. J. Biol. Chem. 268, 2674-2683 (1993).
107. Mölling, K., Wöhrl, B.M., Tisdale, M., Volkmann, S. and Goren, I. RNase H as potential target for anti-viral
drugs. Wiss. Zeitschrift der Humboldt-Univ. zu Berlin, R. Medizin 40, 4, 15-19 (1991).
108. Moelling, K. Minireview: The RNase H of HIV-1. In: Med. Microbiol. Lett. 1, 71-77 (1992).
109. Surovoy, A., Dannull, J., Moelling, K., Jung, G. Conformational and nucleic acid binding studies on the
synthetic nucleocapsid protein of HIV-1. J. Mol. Biol. 229, 94-104 (1993).
110. Volkmann, S., Dannull, J., Moelling, K. The polypurine tract, PPT, of HIV as target for antisense and triplehelix-forming oligonucleotides. Biochimie 75, 71-78 (1993).
111. Moelling, K., Volkmann, S., Dannull, J. Surovoy, A., Jung, G. Analysis of replication of HIV-1 by
mutagenesis of reverse transcriptase and nucleocapsid protein. AIFO 5, 243-248 (1993).
112. Pachuk, C.J., Yoon, K., Moelling, K., Coney, L.R. Selective cleavage of bcr-abl chimeric RNAs by a
ribozyme targeted to non-contiguous sequences. Nucl. Acid. Res. 22, 301-307 (1994).
113. Moelling, K., Volkmann, S. and Dannull, J. Role of RT/RNase H and NC protein during replication of HIV-1.
In: "Virus Strategies: Molecular Biology and Pathogenesis" (W. Doerfler and P. Boehm, eds.) p. 135-152,
VCH Verlag Weinheim (1993).
114. Moelling, K., Bartz, C. und Wiedenmann, B. Gene und Tumorentstehung. In: Expertenseminar, IV.
Pankreaskarzinom - Genese, Epidemiologie, Diagnostik und Therapie (1993).
115. Moelling, K., Mueller, G., Dannull, J., Reuss, C., Beimling, P., Bartz, C., Wiedenmann, B., Yoon, K.,
Surovoy, A. and Jung, G. Stimulation of Ki-ras ribozyme activity by RNA binding protein NCp7 in vitro and in
pancreatic tumor cell line Capan 1. In: "Molecular and Cell Biological Aspects of Gastroenteropancreatic
Neuroendocrine Tumor Disease": (B. Wiedenmann, L.K. Kvols, R. Arnold, E.O. Riecken, eds.) Annals of the
New York Academy of Sciences 733, 113-121 (1994).
Zurich (1993 - present)
116.
**Dannull, J., Surovoy, A., Jung, G. and Moelling, K. Specific binding of HIV-1 nucleocapsid protein to PSIRNA requires N-terminal zinc finger and flanking basic amino acid residues. EMBO J. 13, 1525-1533 (1994).
117. Lovric, J., Bischoff, O. and Moelling, K. Cell cycle-dependent association of Gag-Mil and hsp90. FEBS
Letters 343, 15-21 (1994).
118. Schramm, K., Niehof, M., Radziwill, G., Rommel, C. and Moelling, K. Phosphorylation of c-Raf-1 by protein
kinase A interferes with activation. Biochem. Biophys. Res. Com. 201, 740-747 (1994).
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119. *Coney, L., Wang, B., Ugen, K.E., Boyer, J., McCallus, D., Srikantan, V., Agadjanyan, M., Patchuk, C.J.,
Herold, K., Merva, M., Gilbert, L., Dang, K., Moelling, K., Newman, M., Williams, W.V., and Weiner, D.B.
Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo. Vaccine 12, 1545-1550 (1994).
120.
**Mueller,
G., Strack, B., Dannull, J., Sproat, B., Surovoy, A., Jung, G. and Moelling, K. Amino Acid
Requirements of the nucleocapsid Protein of HIV-1 Increases Catalytic Activity of Ki-ras Ribozyme in vitro. J.
Mol. Biol. 242, 422-429 (1994).
121. Vorbrüggen, G., Kalkbrenner, F., Guehmann, S. and Moelling, K. The carboxyterminus of human c-myb
protein stimulates activated transcription in trans. Nucleic Acids Res. 22, 2466-2475 (1994).
122. Niehof, M., Beimling, P. and Moelling, K. The aminoterminus of c-Raf-1 binds a 28 kD cellular protein.
Biochem. Biophys. Res. Com. 203, 1560-1566 (1994).
123. Beimling, P., Niehof, M., Radziwill, G. and Moelling, K. The aminoterminus of c-Raf-1 binds a protein kinase
phosphorylation Ser259. Biochem. Biophys. Res. Com. 204, 841-848 (1994).
124. Niehof, M., Radziwill, G., Klauser, S. and Moelling, K. A small petptide derived from aminoterminus of cRaf-1 inhibits c-Raf-1/Ras binding. Biochem. Biophys. Res. Com. 206, 46-50 (1995).
125.
**Radziwill,
G., Niehof, M., Rommel, C. and Moelling, K. Direct interaction and aminoterminal
phosphorylation of c-Jun by c-Mil/Raf. Proc. Natl. Acad. Sci. USA 92, 1421-1425 (1995).
126. *Volkmann, S., Jendis, J., Frauendorf, A. and Moelling, K. Inhibition of HIV-1 reverse transcription by triplehelix forming oligonucleotides with viral RNA. Nucl. Acid. Res. 23, 1204-1212 (1995).
127. Nuernberg, W., Artuc, M., Vorbrueggen, G., Kalkbrenner, F., Moelling, K., Czarnetzki, B.M. and
Schadendorf, D. Nuclear proto-oncogene products transactivate the human papillomavirus type 16
promoter. B. J. of Cancer 71, 1018-1024 (1995).
128. Goren, I., Semmes, O.J., Jeang, K.T. and Moelling, K. The amino terminus of Tax is required for interaction
with the cyclic AMP response element binding protein. J.Virol. 69, 5806-5811 (1995).
129. Moelling, K., Radziwill, G., Rommel, C. and Lovric' J. Genetic events in colon carcinoma. In: "Malignancy
and Chronic Inflammation in the Gastrointestinal Tract - New Concepts" (E.O. Ricken, M Zeitz, A. Stallmach
and W. Heise, eds.) p. 93-97, Kluwer Academic Publishers Dordrecht (1995).
130. Schmalzbauer, E., Strack, B., Dannull, J., Guehmann, S. and Moelling, K. Mutations of basic amino acids of
NCp7 of HIV-1 affect RNA binding in vitro. J. Virol. 70, 771-777 (1996).
131. John, M., Meyerhof, W., Richter, D., Waser, B., Schaer, J.-C., Scherübl, H., Boese-Landgraf, J., Neuhaus,
P., Ziske, C., Moelling, K., Riecken, E.-O., Reubi, J.C. and Wiedenmann, B. Positive somatostatin receptor
scintigraphy correlates with the presence of somatostatin receptor subtype 2 and 5. GUT 38, 33-39 (1996).
132. Bartz, C., Ziske, C., Wiedenmann, B. and Moelling, K. p53 tumor suppressor gene expression in human
133. *Rommel, C., Radziwill, G., Lovric', J., Noeldeke, J., Heinicke, T., Jones, D., Aitken, A. and Moelling, K.
Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1. Oncogene 12, 609-619 (1996).
134. Wang, B., Boyer, J., Srikantan, V., Ugen, K., Agadjanian, M., Merva, M., Gilbert, L., Dang, K., McCallus, D.,
Moelling, K., Carrano, R., Williams, W.V., Coney, L. and Weiner, D. DNA Inoculation Induces cross clade
Anti-HIV-1 responses. In: “Annals of the New York Acadeny of Science: DNA Vaccines: A new era in
Vaccinology“ (M.A. Liu, M.R. Hillemann and R. Kurth, eds.), 186-197, New York Academy of Sciences
(1995)
135. Moelling, K., Strack, B., Pavlovic, J., Coney, L., Ciccarelli, R., Carrano, R., Wang, J., Boyer, J. and Weiner,
D. Polynucletoide vaccine against HIV-1. In: "Colloque des Cent Gardes, Retroviruses of Human AIDS and
Related Animal Diseases". (M. Girard and B. Dodet, eds.) (1995).
136. Moelling, K., Strack, B. and Radziwill, G. Signal Transduction as Target of Gene Therapy. In: "New
Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors" (E.D. Kreuser and P.M.
Schlag, eds.), Springer-Verlag Berlin Heidelberg (1996).
137. Lovric', J. and Moelling, K. Activation of Mil/Raf protein kinases in mitotic cells. Oncogene 12, 1109-1116
(1996).
138. Lovric', J., Radziwill, G. and Moelling, K. Specific association of Mil/Raf proteins with a 34 kDa
phospoprotein. Oncogene 12, 1145-1151 (1996).
139. Moelling, K., Pavlovic, J., Strack, B. and Nawrath, M. Polynucleotide-induced immune response against
HIV-NC. In: Ottawa Workshop 1995 on "Gene delivery system" ,A State-of-the-Art review. OECD
Documents, 335-341 (1996).
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140. Pavlovic, J., Nawrath, M., Tu, R., Heinicke, T. and Moelling, K. Anti-tumor Immunity is involved in the
thymidine kinase-mediated killing of tumors induced by activated Ki-ras (G12V). Gene Therapy 3, 635-643
(1996).
141. *Jendis, J., Strack, B., Volkmann, S. and Moelling, K. Inhibition of replication of fresh HIV-1 patient isolates
by a polypurine tract-specific self-complementary oligonucleotide. AIDS Research and Human Retroviruses
12, 1161-1168 (1996).
142. Vorbrueggen, G., Lovric', J. and Moelling, K. Functional analysis of phosphorylation at serine 532 of human
c-Myb by MAP-kinase. Biol. Chem. 377, 721-730 (1996).
143. Radziwill, G., Steinhusen, U., Aitken, A. and Moelling, K. Inhibition of Raf/MAPK signaling in Xenopus
oocyte extracts by Raf-1 specific peptides. Biochem. Biophys. Res. Com. 227, 20-26(1996).
144. Moelling, K. Naked DNA for vaccine or therapy. J. Mol. Med., 75, 242-246 (1997) (invited editorial).
145. Moelling, K., Strack, B., Nawrath, M., Döhring, C., Wagner, N.S. and Pavlovic, J. Development of a DNA
vaccine against malignant melanoma. In: Strategies for Immunointervention in Dermatology (G. Burg and R.
Dummer, eds), Springer-Verlag, 195-206 (1997).
146. *Rommel, C., Radziwill, G., Moelling, K. and Hafen, E. Negative regulation of Raf activity by binding of 143-3 to the amino terminus of Raf in vivo. Mechanisms of Development 64, 95-104 (1997).
147. Zimmermann S., Rommel C., Ziogas A., Lovric' J., Moelling K. and Radziwill G. MEK1 mediates a positive
feedback on Raf-1 activity independently of Ras and Src. Oncogene 15, 1503-1511 (1997).
148. Moelling, K. DNA for genetic vaccination and therapy. Cytokines Cellular and Molecular Therapy 3, 127-136
(1997).
149. Buchert M., Schneider S., Adams, M.T., Hefti H.P., Moelling K. and Hovens C.M. Useful vectors for the twohybrid system in mammalian cells. BioTechniques 23, 396-402 (1997).
150. Schneider, S., Buchert, M., Adams, M.T., Moelling, K., Hovens Chr. M. Dual translation cassettes which
allow prokaryotic and vertebrate protein expression from the same vector. Elsevier Trends Journals
Technical Tips Online, Document PII: S0168-9525 (97)01086-X (1997).
151. *Dubois, T., Rommel, C., Howell, S., Steinhussen, U., Soneji, Y., Morrice, N., Moelling, K., and Aitken, A.
14-3-3 Is phosphorylated by casein kinase I on residue 233.J. Biol. Chem., 272: 28882-28888 (1997).
152. *Bachmann, A.S, Surovoy, A., Jung, G., and Moelling, K. Integrin receptor-targeted transfer peptides for
efficient delivery of antisense oligodeoxynucleotides. J Mol Med 76, 126-132 (1998).
153. Golay, J., Broccoli, V., Borleri, G.-M., Erba, E., Faretta, M., Basilico, L., Ying, G.-G., Piccinini, G., Shapiro,
L.H., Lovric, J., Nawrath M., Moelling, K., Rambaldi, A. and Introna M. Redundant functions of B-Myb and
c-Myb in differentiating myeloid cells. Cell Growth and Differentiation, 8 (12), 1305-1316 (1997).
154. Moelling, K. Naked DNA - the poor man's gene therapy? Gene Therapy 5, 573-574 (1998) (invited
editorial).
155. Dummer, R., Yue F.-Y., Döhring, Ch., Pavlovic, J., Moelling K., Geertson, R., Burg, G. Immune stimulatory
potential of B7.1 and B7.2 retrovirally transduced melanoma cells: B7.2 suppression by interleukin 10.
British Journal of Cancer 77 (9), 1413-1419 (1998).
156. Schneider, S., Georgiev, O., Buchert, M., Adams, M.T., Moelling, K. and Hovens, C.M. An epitope tagged
mammalian/prokaryotic expression vector with positive selection of cloned inserts. Gene 197, 337-341
(1997).
157. Jendis, J., Strack, B. and Moelling, K. Inhibition of replication of drug-resistant HIV Type 1 isolates by
polypurine tract-specific oligodeoxynucleotide TFO A. AIDS Research and Human Retroviruses 14, 9991005 (1998).
158. Ziogas, A., Lorenz, I. C., Moelling K. and Radziwill G. Mitotic Raf-1 is stimulated independently of Ras and
is active in the cytoplasm. J. Biol. Chem. 273, 24108-24114 (1998).
159. Jonas, S., Springmeier, G., Tauber, R., Wiedenmann, B., Lobeck, H., Bechstein, W.O., Kling, N., Moelling,
K. and Neuhaus, P. p53-mutagenesis in klatskin tumors. Human pathology 29 (9), 955-960 (1998).
160. Rothmann, K., Schnoelzer, M., Radziwill, G., Hildt, E., Moelling, K. and Schaller, H. Host cell-virus cross
talk: phosphorylation of a Hepatitis B virus envelope protein mediates intracellular signaling. Journal of
Virology 72, 10138-10147 (1998).
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161. Heinrich, J., Strack, B., Nawrath, M., Pavlovic, J., Moelling, K Immunization with naked DNA coexpressing
antigen and cytokine via IRES, in DNA vaccines: Methods and Protocols, eds. Douglas B.Lowrie and Robert
Whalen, Methods in Molecular Medicine (1998), series editor John W. Walker, 335-344 (1999).
162. Nawrath, M., Heinrich, J., Strack, B., Pavlovic, J. and Moelling, K. A DNA vaccine against malignant
melanoma coexpressing antigen and cytokine. Adv Exp Med Biol, 451, 305-10 (1998).
163. Nawrath, M., Pavlovic, J., Dummer, R., Schultz, J., Strack, B., Heinrich, J. and Moelling, K. Reduced
melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen
gp100/pmel17. Leukemia 13, Suppl. 1, S48-S51 (1999).
164. *Schultz, J., Pavlovic, J., Strack, B., Nawrath, M. and Moelling, K. Long-lasting anti-metastatic efficiency of
IL-12-encoding plasmid DNA. Human Gene Therapy 10, 407-417 (1999).
165. Yoon, K., Jendis, J. and Moelling K. „RNA and triple helices„ in „Triple Helix-Forming Oligonucleotides„, a
volume of the series „Developments in Antisense research” ed. C. Malvy. Kluver Acad. Publishers, Norwell,
MA, USA, 233-242 (1999).
166. *Buchert, M., Schneider, S., Adams, M., Baechi, T., Moelling, K. and Hovens, C.M. The junction-associated
protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinase at specialized sites of cell-cellcontact in the brain. J. Cell Biol 144, 361-371 (1999).
167.
***Schneider,
S., Buchert, M., Adams, M., Baechi, T., Moelling, K. and Hovens, C.M. Mutagenesis and
selection of PDZ domains able to bind to new protein targets. Nature Biotechnology 17, 170-175 (1999).
168. Operschall, E., Schuh, T., Heinzerling, L., Pavlovic, J. and Moelling, K. Enhanced protection against viral
infection by co-administration of plasmid DNA coding for viral antigen and cytokines in mice. Journal of
Clinical Virology 13, 17-27 (1999).
169. Kasono, K., Piché, A., Xiang, J., Kim, H., Bilbao, G., Johanning, F., Nawrath, M., Moelling, K. and Curiel,
D.T. Functional knock-out of c-myb by an intracellular anti-c-Myb single-chain antibody. Biochem. Biophys.
Res. Com., 251, 124-130 (1999).
170.
***Lowrie, D.B., Tascon, R.E., Bonato, V.L.D., Lima, V.M.F., Faccioli, L.H., Stavropoulos, E., Colston, M.J.,
Hewinson, R.G., Moelling, K. and Silva, C.L. Therapy of tuberculosis in mice by DNA vaccination. Nature
400, 269-271 (1999).
171. Heinicke, T., Radziwill, G., Nawrath, M., Rommel, C., Pavlovic, J. and Moelling, K. Retroviral gene transfer
of dominant negative Raf-1 mutants suppresses Ha-ras-induced transformation and delays tumor formation.
Cancer Gene Therapy 7, 697-706 (2000).
172. Schuh, T., Schultz, J., Moelling, K. and Pavlovic, J. DNA-based vaccine against La Crosse virus: protective
immune response mediated by neutralizing antibodies and CD4+ T cells. Human Gene Therapy 10, 16491658 (1999).
173. Heinrich, J., Bosse, M., Eickhoff, H., Nietfeld, W., Reinhardt, R., Lehrach, H. and Moelling, K. Induction of
putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted
subtractive hybridization. Journal of Molecular Medicine 78, 380-388 (2000).
174. Nawrath, M., Pavlovic, J. and Moelling, K. Inhibition of human hematopoietic tumor formation by targeting a
repressor Myb-KRAB to DNA. Cancer Gene Therapy 7, 963-972 (2000).
175.
***Rommel,
176.
***Zimmermann,
Ch., Clarke, B.A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K.,
Yancopoulos, G.D. and Glass, D.J. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by
Akt. Science 286, 1738-1741 (1999).
S. and Moelling, K. Phosphorylation and regulation of Raf by Akt (protein kinase B).
Science 286, 1741-1744 (1999).
177. Nawrath, M., Pavlovic J. and Moelling, K. Synergistic effect of a combined DNA and peptide vaccine
against gp100 in a malignant melanoma mouse model. Journal of Molecular Medicine 79, 133-142 (2001).
178. Walter, E., Moelling, K., Pavlovic, J. and Merkle, H.P. Microencapsulation of DNA using poly(DL-lactide-coglycolide): stability issues and release characteristics. Journal of Controlled Release 61, 361-374 (1999).
179. Schultz, J., Pavlovic, J. and Moelling, K. Immune modulation in cancer using DNA inoculation – antitumour
effect of interleukin-12. Developments in Biologicals 104, 109-114 (2000).
180. Di Carlo, E., Comes, A., Basso, S., De Ambrosis, A., Meazza, R., Musiani, P., Moelling, K., Albini, A. and
Ferrini, S. The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T
and NK cell involvement. The Journal of Immunology 165, 3111-3118 (2000).
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181. *Schultz, J., Heinzerling, L., Pavlovic, J. and Moelling, K. Induction of long-lasting cytokine effect by
injection of IL-12 encoding plasmid DNA. Cancer Gene Therapy 7, 1557-1565 (2000).
182. Schultz, J., Dollenmaier, G. and Moelling, K. Update on antiviral DNA vaccine research. Intervirology 43,
197-217 (2000).
183. Pavlovic, J., Schultz, J., Hefti, H.P., Schuh, T. and Moelling, K. DNA vaccination against La Crosse Virus.
Intervirology 43, 312-321 (2000).
184. Operschall, E., Pavlovic, J., Nawrath, M. and Moelling, K. Mechanism of protection against influenza A virus
by DNA vaccine encoding the hemagglutinin Gene. Intervirology 43, 322-330 (2000).
185.
**Heinzerling,
L., Feige, K., Rieder, S., Akens, M., Dummer, R., Stranzinger, G., Moelling, K. Tumor
regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma
metastases in gray horses. Journal of Molecular Medicine 78, 692-702 (2001).
186. Heller, R., Schultz, J., Lucas, ML., Jaroszeski, MJ., Heller, LC., Gilbert, RA., Moelling, K. and Nicolau, C.
Intradermal delivery of interleukin-12 plasmid DNA by in vivo electroporation. DNA Cell Biol. 20, 21-26
(2001).
187. *Reusch, H.P., Zimmermann, S., Schaefer, M., Paul, M., Moelling, K. Regulation of Raf by Akt controls
growth and differentiation in vascular smooth muscle cells. J. Biol. Chem. 276, 33630-33637 (2001).
188. Weber, R., Bossart, W., Cone, R., Luethy, R., Moelling, K. Phase I clinical trial with HIV-1 gp160 plasmid
vaccine in HIV-1-infected asymptomatic subjects. Eur. J. Clin. Microbiol. Infect. Dis. 20, 800-803 (2001).
189. Pavlovic J., Schultz J. and Moelling, K. Selective lysis of tumor cells with a deficiency in the interferon type I
system with influenza A virus in vivo. Gene Therapy. 2001; 8:S10.
190. Heinzerling, L., Dummer, R., Pavlovic, J., Schultz, J., Burg, G., Moelling, K. Tumor regression of human
and murine melanoma after intratumoral injection of IL-12 encoding plasmid DNA in mice. Exp. Derm. 11,
232-241 (2002).
191. Pavlovic, J., Petrzilka, D., Operschall, E., Moelling, K. Protection against influenza A virus by DNA
vaccination depends on the humoral response and dose of challenge virus. Vaccine 20, 1692-1699 (2002).
192. Heinrich, J., Schultz, J., Bosse, M., Ziegelin, G., Lanka, E., Moelling, K. Linear closed mini DNA generated
by the procaryotic cleaving-joining enzyme TelN. J. Mol. Med. 80, 648-654 (2002).
193. Moelling, K., Schad, K., Bosse, M., Zimmermann, S., Schweneker, M. Regulation of Raf-Akt cross-talk. J.
Biol. Chem. 34, 31099-31106 (2002).
194. Ladell, K., Heinrich, J., Schweneker, M., Moelling, K. A combination of plasmid DNAs encoding murine Flk1 extracellular domain, murine IL-12 and murine IP-10 lead to tumor regression and survival in melanomabearing mice. J. Mol. Med. 81, 271-278 (2003).
195. *Radziwill, G., Erdmann, R.A., Margelisch, U., Moelling K. The Bcr kinase downregulates Ras signaling by
phosphorylating AF-6 and binding to its PDZ domain. Molecular and Cellular Biology 23, 13, 4663-4672
(2003).
196. Morini, M., Albini, A., Lorusso, G., Moelling, K., Lu, B., Cilli, M., Ferrini, S., Noonan, D.M. Prevention of
angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immuno-gene therapy. Gene Ther. 11,
3, 284-91 (2004).
197. Keyser, J., Schultz, J., Ladell, K., Elzaouk, L., Heinzerling, L., Pavlovic, J., Moelling K. IP-10-encoding
plasmid DNA therapy exhibits antitumor and antimetastatic efficiency. Experimental Dermatology, 13, 380390 (2004).
198. Boisguerin, P., Leben. R., Ay. B., Radziwill G., Moelling K., Dong, L., Volkmer-Engert R. An Improved
Method for the Synthesis of Cellulose Membrane-Bound Peptides with Free C Termini is Useful for PDZ
Domain Binding Studies Chemistry & Biology 11, 449-459 (2004).
199. Pap, Th., Nawrath, M., Heinrich, J., Bosse, M., Baier, A., Hummel, K.M., Petrow, P., Kuchen, S., Michel,
B.A., Gay, R.E., Müller-Ladner, U., Moelling K., Gay St. Cooperation of Ras- and Myc-dependent pathways
in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis Arthritis &
Rheumatism 50, 9, 2794-2802 (2004).
200. Schultz, J., Salzer, U., Mohajeri, M.H., Franke, D., Heinrich, J., Pavlovic, J., Wollmer, M.A., Nitsch, R.,
Moelling K. Antibodies from a DNA-peptide vaccination decrease the brain amyloid burden in a mouse
model of AD J. Mol. Med., 82, 706-714 (2004).
201.
**Heinzerling, L., Burg, G., Dummer, R., Oberholzer, P., Schultz, J., Elzaouk, L., Pavlovic. J., Moelling. K.
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Intratumoral Injection of DNA Encoding Human Interleukin-12 into Patients with Metastatic Melanoma:
Clinical Efficacy Human Gene Therapy 16, 35-48 (2005).
202. Wiedemann, U., Boisguerin, P., Leben, R., Leitner, D., Krause, G., Moelling K., Volkmer-Engert R. and
Oschkinat H. Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of
super-binding peptides. J. Mol. Biol., 343, 703-718 (2004).
203. Schweneker, M., Bachmann, A.S. and Moelling, K. The HIV-1 co-receptor CCR5 binds to α-catenin, a
component of the cellular cytoskeleton. Biochem. Biophys. Res. Commun., 325, 751-757 (2004).
204. Schweneker, M., Bachmann, A.S. and Moelling, K. JM4 – is a four-transmembrane protein binding to the
CCR5 receptor. FEBS Letters 579, 1751-1758 (2005).
205. Ziogas, A., Moelling, K. and Radziwill, G. CNK1 is a scaffold protein that regulates Src-mediated Raf-1
activation. J Biol Chem. 280, 25, 24205-24211 (2005).
206.
**Ress,
A., Moelling, K. Bcr is a negative regulator of the Wnt signalling pathway. EMBO reports 6, 11,
1095-1100 (2005).
207. Ress, A. and Moelling, K. Bcr interferes with β-catenin-Tcf1 interaction FEBS Letters 580, 1227-1230
(2006).
208. *Lorger, M. and Moelling, K. Regulation of epithelial wound closure and cell-cell adhesion by interaction of
AF6 with actin cytoskeleton. JCS 119, 3385-3398 (2006).
209. Moelling, K., Abels, S., Jendis, J, Ziogas, A., Matskevich, A. and Heinrich, J. Silencing of HIV by hairpinloop-structured DNA oligonucleotide (siDNA). FEBS Letters, 580, 3545-3550 (2006).
210. *Fritzius, Th., Burkard, G., Haas, E., Heinrich, J., Schweneker, M., Bosse, M., Zimmermann, S., Frey, A.D.,
Caelers, A., Bachmann, A.S. and Moelling, K. A WD-FYVE protein binds to the kinases Akt and PKCζ/λ.
Biochemical Journal, 399, 9-20 (2006).
211. Ress, A. and Moelling, K. Interaction partners of the PDZ domain of Erbin. Protein & Peptide Letters 13,
877-881 (2006).
212. Matskevich, A.A., Ziogas, A., Heinrich, J., Quast, S.A. and Moelling, K. Short Partially Double-Stranded
Oligodeoxynucleotide Induces Reverse Transcriptase/RNase H-Mediated Cleavage of HIV RNA and
Contributes to Abrogation of Infectivity of Virions. AIDS Res. and Hum. Retroviruses 22, 12, 1220-1230
(2006).
213. Elzaouk, L., Moelling, K. and Pavlovic, J. Antitumor activity of mesenchymal stem cells producing murine IL12 in a mouse melanoma model. Exp. Dermatology 15, 865-874 (2006).
214. Joshi, M., Vargas, C., Moelling, K., Boisguerin, P., Diehl, A., Krause, G., Schmieder, P., Hagen, V., Schade,
M. and Oschkinat, H. Discovery of low-molecular-weight ligands for the AF6PDZ domain. Angew. Chem. Int.
Ed. 45, 3790-3795 (2006).
215. Elzaouk, L., Pavlovic, J. and Moelling, K. Analysis of antitumor activity elicited by vaccination with
combinations of IL-12 DNA with gp100 DNA or the chemokine CCL21 in vivo. Hu Gene Ther 17, 859-870
(2006).
216. Usluoglu, N., Pavlovic, J., Moelling, K. and Radziwill, G. RIP2 mediates LPS-induced p-38 and IκBα
signaling including IL-12 p40 expression in human monocyte-derived dendritic cells Eur. J. Immunol. 37,
2317-2325 (2007).
217.
**Moelling,
K., Matskevich, A. and Jung, J.-S. Relationship between retroviral replication and RNA
interference machineries. Cold Spring Harbor Symp. on Quant. Biol., Vol. 71, 365-368 (2006).
218. *Radziwill, G., Weiss, A., Heinrich, J., Baumgartner, M., Boisguerin, P., Owada, K. and Moelling, K.
Regulation of c-Src by binding to the PDZ domain of AF-6. EMBO J, 26, 2633-2644 (2007).
219. Fritzius, Th., Frey, A.D., Schweneker, M., Mayer, D. and Moelling, K. WD- repeat-propeller-FYVE protein,
ProF, binds VAMP2 and protein kinase Cζ. FEBS Journal 274, 1552-1566 (2007).
220.
***Matzen, K., Elzaouk, L., Matskevich A.A., Nitzsche, A., Heinrich, J. and Moelling, K. RNase H-mediated
retrovirus destruction in vivo triggered by oligodeoxynucleotides. Nature Biotechnol. 25, 669-674 (2007).
Editorial Comment: Assisted suicide for retroviruses Nature Biotechnol. 25,643-644(2007)
221. Ortner, E. and Moelling, K. Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced
signaling. Biochem. Biophys. Res. Commun. 362, 454–459 (2007).
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222. Matskevich, A. and Moelling, K. Dicer is involved in protection against influenza A virus infection J. Gen.
Virol. 88, 2627-2635 (2007).
223. Weiss, A., Baumgartner, M., Radziwill, G. Dennler, J. and Moelling, K. c-Src is a PDZ-interacting partner
and substrate of the E3 ubiquitin ligase ligand-of-numb protein X1. FEBS Lett. 581, 5131-5136 (2007).
224. Boisguerin, P., Ay, B., Radziwill, G., Fritz, R.D., Moelling, K. and Volkmer, R. Characterization of a Putative
Phosphorilation Switch: Adaption of SPOT Synthesis to analyze PDZ Domain Regulation Mechanisms
ChemBioChem 8, 2302-2307 (2007).
Publications as Fellow 2008/2009 at Institute of Advanced Study (Prof.em from Zurich University)
225. *Baumgartner, M., Radziwill, G. Lorger, M., Weiss, A. and Moelling, K. c-Src-mediated epithelial cell
migration and invasion regulated by PDZ binding site. Molecular and Cellular Biology, 28, 642-655 (2008).
226. Keyser, J., Lorger, M., Pavlovic, J., Radziwill, G. and Moelling, K. Role of AF6 protein in cell-to-cell spread
of Herpes simplex virus 1. FEBS Letters 581, 5349-5354 (2008).
227. *Fritzius, Th. and Moelling, K. Akt- and Foxo1- interacting WD-repeat-FYVE protein promotes adipogenesis
EMBO J 27, 1399-1410 (2008).
228. Matskevich, A.A. and Moelling, K. Stimuli-dependent cleavage of Dicer during apoptosis. Biochem J. 412,
527-534 (2008).
229. Ress, A. and Moelling, K. The PDZ-protein Erbin modulates β-catenin-dependent transcription Eur Surg
Res. 41 (3), 284-289 (2008).
230. Kwok, T., Helfer, H., Alam, M.I., Heinrich, J., Pavlovic, J., and Moelling, K. Inhibition of influenza A virus
replication by short double-stranded oligodeoxynucleotides. Arch Virol 154, 109-114 (2009).
231. *Heinrich, J., Mathur, S., Matskevich, A.A., and Moelling, K. Oligonucleotide-mediated retroviral RNase H
activation leads to reduced HIV-1 titer in patient-derived plasma. AIDS 23, 213-221 (2009). Editorial
*Comment: Mark Wainberg: New findings on blockage of HIV-1 RNase H activity
232. Wittmer-Elzaouk, L., Jung-Shiu, J., Heinrich, J., and Moelling, K. Retroviral self-inactivation in the mouse
vagina induced by short DNA. Antiviral Res 82, 22-28 (2009).
233. Falkenhagen, A., Heinrich, J., and Moelling, K. Short hairpin-loop-structured Oligodeoxynucleotides reduce
HSV-1 Replication. Virology Journal 6, 43 (2009).
234. Noreen, F., Heinrich, J. and Moelling, K. Anti-tumor activity of small double-stranded oligodeoxynucleotides
targeting telomerase RNA in malignant melanoma cells. Oligonucleotides 19:2, 169-178 (2009).
235. Kwok, T., Heinrich, J., Jung-Shiu, J., Meier, M.G., Mathur, S., and Moelling, K. Reduction of gene
expression by a hairpin-loop structured oligodeoxynucleotide: alternative to siRNA and antisense. Biochim
Biophys. Acta 1790, 1170-8 (2009).
236. Matskevich, A.A., Jung J.-S., Schürmann M., Cascallo M. and Moelling, K. Vero cells as a model to study
the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infection. J. Innate
Immunity 1, 389-394, (2009).
237. Baumgartner, M., Weiss, A., Fritzius, T., Heinrich, J., and Moelling, K. The PDZ protein MPP2 interacts
with c-Src in epithelial cells. Experimental Cell Research 315: 2888-2898 (2009).
238. Hofmann M., Heinrich, J., Radziwill, G., and Moelling, K. A short hairpin DNA analogous to miR125b
inhibits C-Raf expression, proliferation and survival in breast cancer cells. Molecular Cancer Research 7,
1635-1644 (2009).
Manuscripts not yet published:
239. Audige, A., Baenziger, S., Schweneker, M., and Speck, R.F. CD4/CCR5 signaling affects HIV replication in
an isolate-dependent manner (submitted).
240. Pavlovic, J., Fischer, M., Tan, J., Hilgenfeld, R. and Moelling, K. Influenza virus Inhibitor against wild-type
and mutant neuraminidase (to be resubmitted).
241. Pavlovic, J., Operschall, E. and Moelling, K. Memory B cells induced by Fc-receptor-targeted influenza
virus DNA vaccine (submitted).
242. **Heinrich, J., Schols, D. and Moelling, K. Inhibition
oligodeoxynucleotide in humanized SCID mice in vivo (submitted)
of
HIV-1
by
hairpin-loop-structured
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243. Vargas, C., Radziwil, G., Krause, G., Diehl, A., Keller, S., Schmieder, P., Doyle, D., Moelling, K., Hagen, V.,
Schade, M. and Oschkinat, H. Small-molecule inhibitors of AF6-mediated protein-protein interactions (to be
resubmitted)
244. Fritzius, T., Heinrich, J. and Moelling, K. Liver steatosis in mice correlates with increased expression of
adipocyte differentiation marker ProF(in prep)
245. Heinrich, J. and Moelling K. Inhibition of lentiviral replication by short hairpin-loop-structured
oligodeoxynucleotides, analysis of G-quadruplex formation, role of polypurine-tract (PPT) with siRNA,
comparison of the two PPTs, viral escape mutants in short-term HIV serial passages.(in prep.)
246. Bröcker, F. Inhibition of HCV replicons by oligodeoxynucleotides Thesis into paper.
247. Heinrich, J., Shattock ,R. and Moelling, K. Inhibition of HIV in vagina explants. Moelling et al. HBV and
ODN inhibition (ongoing)
248. Moelling et al. HBV and ODN inhibition (ongoing)
249. Moelling et al. PDZ Domains in signaling pathways. (invited Review in Cellular and Molecular Life Sciences,
Birkhäuser Verlag))
250. Moelling et al. RNases H of retroviruses and cells (invited Review in ChemBioChem)
251. Moelling: RNase H, biochemistry and activity, in Human Retroviruses, ed G.Poli (invited review)
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Books
1.
“Das AIDS Virus“", Verlag Chemie, Weinheim 1988, 265 S.
2.
„Retroviren in der Krebs- und Aids-Forschung“, Bertha-Benz-Vorlesung, gehalten am 23. Juni 1988 an der
Universität Heidelberg, Ladenburg 1990.
3.
“AIDS - Eine Herausforderung an die Wissenschaft“, 4. Bericht zur Forschungsförderung des BMFT. Der
Bundesminister für Forschung und Technologie, Oeffentlichkeitsarbeit, Bonn, Juni 1990.
4.
Editor of Book on "Viral DNA Vaccines" in „Intervirology“, S. Karger AG, Basel, 43, 4-6, 2000.
Book chapters
1.
"Die Gene und der Krebs", in "Mannheimer Forum 91/92", S. 69-128. Herausgeber E.P. Fischer, Piper
Verlag, München, Zürich (1991).
2.
Herausgeber E.P. Fischer, Piper Verlag, München, Zürich (1991).
3.
"Beziehung zwischen Viren und bösartigen Geschwülsten (2): Molekularbiologie der Onkogenese" in
"Medizinische Mikrobiologie", Herausgeber: H. Hahn, D. Falke, P. Klein. Springer Verlag, S. 654-675,
(1991).
4.
"Gentherapie durch und von Virusinfektionen", in: Ethik und Gentherapie, Ethik in den Wissenschaften (7),
S. 66-73, Herausgeber C. Rehmann-Sutter, H. Müller, Attempto Verlag Tübingen.
5.
"Beziehung zwischen Viren und bösartigen Geschwülsten (2): Molekularbiologie der Onkogenese" in
(1994), 2. Auflage.
6.
Moelling K., Nawrath M., Heinrich J., Strack B., Schultz J., Wagner S.N., Pavlovic J.: "Development of a
DNA Vaccine against Malignant Melanoma", in: Molekularbiologie in der Inneren Medizin, Schriftenreihe der
Gesellschaft für Fortschritte in der Inneren Medizin, Georg Thieme Verlag, S. 137-144 (1997).
7.
Yoon, K., Jendis, J. and Moelling K.: „RNA and triple helices„ in „Triple Helix-Forming Oligonucleotides„, a
volume of the series „Developments in Antisense research„, ed. C. Malvy and A. Havel-Bellan, Kluver
Academic Publishers, Norwell, MA, La Crosse Virus, Intervirology.
8.
Pavlovic, J., Schultz, J., Hefti, H.P., Schuh, T. and Moelling, K.: DNA Vaccination against La Crosse Virus,
Intervirology.
9.
Franke D., Pavlovic J., Utesch T.S., von Kleist M., Schultz J., Dollenmaier G., Moelling K. "Update on
Antiviral DNA Vaccine Research (2000-2003)" in: "Novel Vaccination Strategies", ed. S.H.E. Kaufmann,
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, S. 289-317 (2004).
10. Moelling K.: “An den Grenzen des Wissens: Leben Viren?”, Interdisziplinäre Veranstaltungsreihe der
Universität und der ETH Zürich, Zürcher Hochschulforum, Hochschulverlag AG, ETH Zürich (2007)
Co author:
"Denkschrift Parasitologie" DFG, Verlag Chemie, 1989.
"Harrisons Innere Medizin 1,2", 13. Auflage, Deutsche Ausgabe, Blackwell Wissenschafts-Verlag, Berlin (1995) (
2002).
„Springer Lexikon Medizin“, P. Reuter (Hsg.), Springer-Verlag Berlin, Heidelberg, New York, S. 2185-2197
(2004).
Mitverfasserin des Memorandums (1997): Biotechnologie, Gentechnik und wirtschaftliche Innovation, Kapitel
"Forschung und Forschungsförderung". Rat für Forschung, Technologie und Innovation des Bundeskanzlers Dr.
H. Kohl.
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Publications in Medical Journals
1.
Blasenkrebs: Tumorvirus-Gen nachgewiesen.
Aerztliche Praxis XXXV 75, 2219 (1983).
2.
Replikation von LAV/HTLV-III Virus.
AIFO (Zeitschrift für AIDS-Forschung) 4, 172-176 (1986).
3.
Neue AIDS Viren gefunden. AIFO 6, 283-284 (1986).
4.
Verbesserte Diagnostik - aber keine Therapie
Die Neue Ärztliche 121, 7 (1986).
5.
Cyclosporin als Immunmodulator.
Die Neue Ärztliche 240, 9 (1986).
6.
Die Nobel-Faktoren.
Fortschritte der Medizin 43, 12-13, 52-53 (1986).
7.
Das genetische Make-up von HTLV-III-Viren.
AIFO 1, 38-45 (1987).
8.
Manipulation im Immunsystem.
Fortschritte der Medizin 5, 88 (1987).
9.
Reverse Transkription und Reverse Transkriptase.
Dt. Ärzteblatt 8, 436-443 (1988).
10. Dextransulfat gegen AIDS?
Dt. Ärzteblatt 9, 529-534 (1989).
11. PCR: Genanalyse ohne Gentechnik
Dt. Ärzteblatt 37, 2531-2536 (1989).
12. Herkunft und Wirkung der Onkogene
Dt. Ärzteblatt 86, 3606-3610 (1989).
13. Nackte DNA aus der Impfpistole
Dt. Aerzteblatt 92, 2902-2912 (1995).
14. Nackte DNA zur Impfung und Therapie
Deutsche Medizinische Wochenschrift 23/122, 757-760 (1997).
15. DNA-Vakzine. Impfung und Gentherapie mit nackter DNA
Der Informierte Arzt 19: 459-462 (1998).
16. Betrug in der Wissenschaft
Bild der Wissenschaft 11, 22-24 (1997).
17. DNA hat Killerinstinkt
Spektrum der Wissenschaft (in press).
18. Trojanische Schweine
19. Impfung und Gentherapie mit nackter DNA.
Zeitschrift für ärtzliche Fortbildung 92, 681-683 (1998).
20. Dagmar Schipanski - die Kandidatin
21. Kalt erwischt von der Schweinegrippe
Migros-Magazin 38,Sept.2009
22. Nobelpreis 2009 – Ein Blick hinter die Kulissen
Schweizer Zeitschrift für Ernährungsmedizin 5 (2009)
23. HIV in den Selbstmord treiben. Leading Opinions in
Infektiologie, Wien 8 (2010)
Publications in Newspapers
1.
Nackte DNA als neuer Impfstoff gegen HIV
Neue Zürcher Zeitung, Forschung und Technik vom 4.10.95
15
Karin Moelling
16
2.
DNA hat Killer-Instinkt
Neue Zürcher Zeitung vom 29.4.1998
3.
Das Spiel der Singles
unimagazin, Die Zeitschrift der Universität Zürich, 2, 1999
4.
Wettlauf mit dem SARS-Virus
Tages-Anzeiger vom 29.4.03
5.
Schweinegrippe, Angst vor der Schlagzeile
Die Welt Juli 2009
6.
Stammzellen im Vormarsch
Die Welt Aug 2009
25.9.2010 /
Der Informierte Arzt 19: 459-462 (1998).
16. Betrug in der Wissenschaft
17. DNA hat Killerinstinkt
Spektrum der Wissenschaft (in press).
18. Trojanische Schweine
19. Impfung und Gentherapie mit nackter DNA.
Zeitschrift für ärtzliche Fortbildung 92, 681-683 (1998).
20. Dagmar Schipanski - die Kandidatin
21. Kalt erwischt von der Schweinegrippe
Migros-Magazin 38,Sept.2009
22. Nobelpreis 2009 – Ein Blick hinter die Kulissen
Schweizer Zeitschrift für Ernährungsmedizin 5 (2009)
23. HIV in den Selbstmord treiben. Leading Opinions in
Infektiologie, Wien 8 (2010)
International courses
1.
2.
3.
4.
5.
Koorganisatorin eines internationalen Laborkurses der Europäischen Molekularbiologischen Organisation
(EMBO) über RNS-Tumorviren im Fibiger Laboratory, Kopenhagen, 7.-19.6.1976.
Koorganisatorin eines internationalen EMBO-Laborkurses über RNS-Tumorviren im Fibiger Laboratory,
Kopenhagen, 16.-29.10.1977.
Verantwortliche Organisation eines internationalen EMBO-Laborkurses ("Laboratory Course on Advanced
Techniques on RNA Tumor Viruses") am Max-Planck-Institut für Molekulare Genetik in Berlin, 15.27.10.1979.
Workshop on „Evolution of Viruses and Hosts“, Institute of Advanced Studies, Berlin , July 2009
EMBO Global Exchange Lecture Course, HIV/AIDS, Stellenbosch, South Africa, Jan/Febr.2011
16
Karin Moelling
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PHD and MD Theses and Diploma Theses
1.
Ulrike Novak, Diplomarbeit 1978
"Untersuchungen zur Struktur und genetischen Komplexität von in vitro synthetisierter DNS von VogelSarkomviren"
Thomas Bunte, Diplomarbeit 19793
"Hybridisierung als Voraussetzung für DNS-Provirussynthese bei der Replikation von RNS-Tumorviren"
Thomas Bunte, Doktorarbeit 1981
"Lokalisation des Transformationsproteins von Vogel-Sarkomviren in der Virusmembran"
Karl-Walter Sykora, Doktorarbeit 1982
"Reinigung und Charakterisierung eines Nukleinsäure-bindenden Proteins aus Vogel-Retroviren"
Thomas Benter, Doktorarbeit 1986
"Identifizierung und Untersuchung des menschlichen zellulären myc Genproduktes"
Ulrike Lorenz, Diplomarbeit 1986
"Untersuchung der Wechselwirkung des viralen myc-Proteins mit DNA"
Thomas Schulze, Diplomarbeit 1986
"Untersuchung einiger Genprodukte von HIV"
Claudia Beutler, Diplomarbeit 1988
"Herstellung monoklonaler Antikörper gegen das expressionsklonierte Onkogen v-mil"
Kira Schramm, Diplomarbeit 1988
"Regulation der Expression des menschlichen zellulären myc Gens"
Andrea Zobel, Diplomarbeit 1989
"Charakterisierung regulatorischer Regionen des menschlichen c-myc Gens"
Stephan Gühmann, Diplomarbeit 1989
"Funktionelle Charakterisierung des bakteriell exprimierten menschlichen c-myb Gens"
Ulrike Lorenz, Doktorarbeit 1989
"Charakterisierung der Wirkungsweise des Myc-Proteins durch Isolierung und Analyse von zellulären DNAProtein-Komplexen"
Thomas Schulze, Doktorarbeit 19893)
"Molekularbiologische Untersuchungen der Funktionen von rekombinanten HIV-1 pol Genprodukten"
Gerd Vorbrüggen, Diplomarbeit 1990
"Charakterisierung der Wechselwirkung des Myb Proteins mit DNA in vitro und in vivo"
Andrea Zobel, Doktorarbeit 1992
"Charakterisierung der Transkriptionsregulation des menschlichen c-myc-Gens"
Stefan Gühmann, Doktorarbeit 1992
"Untersuchung der spezifischen Wechselwirkung von Myb Proteinen mit DNA"
Gerd Müller, Diplomarbeit (1993)
"Mutagenese des Protoonkogens c-raf-1 und Analyse von Ribozymen gegen das bcr-abl Onkogen
Jens Dannull, Doktorarbeit (1993)
"Charakterisierung des Nukleokapsidproteins von HIV-1"
Lore Grünbaum, Diplomarbeit (1993)
"Untersuchungen zur Expression und Funktion des Raf-Proteins in den Oozyten von Xenopus laevis"
Clemens Bartz, Doktorarbeit (1993)
"Untersuchung des 53-Gens und seiner Genprodukte in endokrinen, pankreatischen Zellinien"
Silke Volkmann, Doktorarbeit (1993)
"Charakterisierung der Reversen Transkriptase/RNase H von HIV-1, Wirkung von Antisense
Oligonukleotiden Tripel-Helix Formation
Edith Schmalzbauer, Dilplomarbeit ( 1993)
"Wechselwirkung des Nukleokapsidproteins NCp7 von HIV-1 und dessen Mutanten mit viraler RNA in vitro"
Gerd Vorbrüggen, Doktorarbeit (1994)
"Charakterisierung der carboxyterminalen Domäne des menschlichen c-Myb-Proteins"
Josip Lovric, Doktorarbeit (1994)
"Zell-Zyklus-abhängige Regulation von Myc- und Raf-Proteinen"
2.
3.
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
3
Für diese Arbeit erhielten Thomas Bunte und Karin Mölling den "Vincenz-Czerny-Preis für Onkologie 1981" von der Deutschen
Gesellschaft für Hämatologie und Onkologie.
17
Karin Moelling
18
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Zürich
22. Jana Nöldeke, Diplomarbeit (1995)
"Untersuchung von Proteinkinase c-Raf-1 assoziierten Proteinen"
23. Ulrike Steinhusen, Diplomarbeit (1995)
"Untersuchungen zur Regulation der Proteinkinase c-Raf-1 in Xenopus laevis Oozyten"
24. Renjing Tu, Doktorarbeit (1995)
"The ras-gene for oncogenicity and vaccination"
25. Kira Schramm, Doktorarbeit (1995)
"Studien zur Aktivität der Serin/Threoninkinase c-Raf-1"
26. Christian Rommel, Doktorarbeit (1996) (Auszeichnung, Preis)
„Molecular and Functional Analysis of the Proetein Kinase c-Raf-1"
27. Mark Adams, Diplomarbeit (1997) (Auszeichnung)
"Isolation of a Ryk interacting protein using the yeast two-hybrid system"
28. Ivo Lorenz, Diplomarbeit ETH (1997)
"Cell Cycle-Dependent Regulation of the Raf-1 Protein Kinase"
29. Magnus Bosse, Diplomarbeit (1997)
Entwicklung eines Systems zur Identifizierung Raf-regulierter Gene
30. Rüdiger Erdmann (1998)
Untersuchung von Protein-Protein-Wechselwirkungen mit Hilfe des Hefe-Zwei-Hybrid-Systems
31. Michael Buchert, Doktorarbeit (1998)
Isolation and characterization of the tight junction - associated protein AF-6 and its role in clustering receptor
tyrosine kinases at membrane specializations in the brain
32. Stefan Schneider, Doktorarbeit (1998)
The production and selection of interaction domains with novel binding specificities through a scaffold-based
evolutionary screen
33. Manfred Kessler, Doktorarbeit
Herstellung von dominant negativen Myb-Mutanten
34. Theda Schuh, Doktorarbeit (experimentell fertiggestellt)
Nackte DNA als Impfstoff gegen LaCrosse Virus
35. Sven Zimmermann, Doktorarbeit (1999) (Auszeichnung, Preis)
The ser/thr kinase Raf as target of signalling cross-talk and feed-back mechanism
36. Marc Schweneker, Diplomarbeit (1999)
Interaktionspartner des HIV-Ko-Rezeptors von CCR5
37. Gunnar Schütz, Diplomarbeit (1999)
Interaktion der Serin/Threonin-Proteinkinase Bcr und dem Ras bindenden Protein AF-6
38. Gesine Rudolph, Diplomarbeit (2000)
Suche nach Interaktionspartnern des EphrinB2 und in vitro Angiogenese
39. Ralph Kretzschmar, Diplomarbeit (2000)
Charakterisierung von AIP, eines neuen mit der Kinase Akt interagierenden Proteins
40. Karen Schad, Diplomarbeit (2000)
Regulation of the Crosstalk between the PI3K-Akt and the Ras-Raf-MEK-ERK pathway in MCF-7 cells
41. Sandra Wechsler, Diplomarbeit (2000)
Interaktion des PDZ Proteins AF-6 mit dem Transkriptionsfaktor MyT1
42. Dag Schauwienold, Diplomarbeit (2000)
Charakterisierung von Bindungspartnern des Raf-1 assoziierten Proteins CNK
43. Nadine Hardel, Diplomarbeit (2001)
Das PDZ-Protein ERBIN bildet einen Komplex mit der Proteinkinase Bcr und dem Protoonkogenprodukt ßCatenin
44. Algirdas Ziogas, Doktorarbeit (2001)
Characterization of the multistep activation of Ser/Thr kinase Raf-1 involving phosphorylation and protein
protein interactions
45. Elisabeth Operschall, Doktorarbeit (2001)
DNA Vaccines Encoding Viral Proteins and Strategies to Improve Immune Responses
46. Buschmann Catharina, Diplomarbeit (2001)
Untersuchung der Wechselwirkung von PDZ-Domänen mit Liganden
47. Ylva Lindman, Doktorarbeit (2001)
Inhibition of tumor formation using the soluble extracellular domain of the EphB3 receptor
18
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48. Nina Raetzel, Diplomarbeit (2002)
Gene silencing bei HIV durch Oligonukleotide
49. Nathalie Constantin, Diplomarbeit (2002)
Identification of the viral target domain of MxA.
50. Sebastian Zurbriggen, Diplomarbeit (2003)
Influence of HIV-1 specific triplex forming oligonucleotides (TFO) on the RNase H and reverse transcriptase
activity in vitro.
51. Sybille Schwendener, Diplomarbeit (2004)
Analysis of triplex formation at the polypurine tract of HIV-1.
52. Junmin Hu, Diplomarbeit (2004)
Generation of replication-competent Semliki-Forrest Virus pseudotyped with the glycoprotein of VSV.
53. Marc Schweneker, Doktorarbeit (2004)
Identification and characterization of two novel proteins interacting with the chemokine- and HIV-1 coreceptor CCR5
54. Magnus Bosse, Doktorarbeit (2004)
PI3K/Akt and Raf/MEK/ERK signalling in adipocytes.
55. Rüdiger Erdmann, Doktorarbeit (2004)
The role of the Bcr kinase and the PDZ domain protein AF-6 in signal transduction.
56. Angelika Reß, Doktorarbeit (2004)
Proteininteraktionspartner von beta-Catenin, Identifikation von Protein-Protein-interkationen,
Charakterisierung von Modulatoren des Wnt-Signaltransduktions-weges, Wege zu einem neuen Verständnis
des Onkogenes Bcr-Abl.
57. Rafael Fritz, Diplomarbeit (2005)
Interaktion zwischen dem Multidomänenprotein CNK1 und dem Angiotensin-rezeptor Typ 2.
58. Sandra Annika Quast, Diplomarbeit (2005)
Inhibition of HIV replication: the preference for cleavage of the PPT-region by oligodeoxyribonucleotides and
uptake of oligodeoxyribonucleotides in cells.
59. Stefan Deuber, Dissertation (2005)
Inhibition of Semliki Forest Virus, replication by the interferon system: Identification of a viral sequence
determining the interferon sensitivity.
60. Thorsten Fritzius, Dissertation (2006)
Propeller Protein Containing a FYVE Domain, ProF: An Adaptor for Kinases involved in Glucose Uptake in
Adipocytes.
61. Bettina Thea Oberle, Dissertation (2006)
Development of a DNA Vaccine Against SARS-CoV. Negative Regulation of the IFN-α Signaling by the
Influenza Matrix Protein (M1).
62. Stephanie Seibt, Diplomarbeit (2006)
Die Rolle des Scaffold-Proteins CNK1 in Ras- und Scr-abhängigen Signalwegen.
63. Annika Kasten, Diplomarbeit (2007)
Die Rolle des Proteins Dicer in Stress-induzierter Apoptose.
64. Ortner, E. Doktorarbeit 2007
Heteromeric complex formation of ASK1 and ASK2 regulates stress-induced signaling Doktorarbeit (2007)
68. Alexander Falkenhagen, A., Diplomarbeit FU Berlin (2009)
Short hairpin-loop-structured Oligodeoxynucleotides reduce HSV-1 Replication.
69. Bröcker, F., Diplomarbeit, TU Berlin (2009)
Inhibition of HCV replicons by oligodeoxynucleotides.
19
Karin Moelling
20
25.9.2010 /
Books
5.
“Das AIDS Virus“", Verlag Chemie, Weinheim 1988, 265 S.
6.
„Retroviren in der Krebs- und Aids-Forschung“, Bertha-Benz-Vorlesung, gehalten am 23. Juni 1988 an der
Universität Heidelberg, Ladenburg 1990.
7.
“AIDS - Eine Herausforderung an die Wissenschaft“, 4. Bericht zur Forschungsförderung des BMFT. Der
Bundesminister für Forschung und Technologie, Oeffentlichkeitsarbeit, Bonn, Juni 1990.
8.
Editor of Book on "Viral DNA Vaccines" in „Intervirology“, S. Karger AG, Basel, 43, 4-6, 2000.
Book chapters
11. "Die Gene und der Krebs", in "Mannheimer Forum 91/92", S. 69-128. Herausgeber E.P. Fischer, Piper
Verlag, München, Zürich (1991).
12. Herausgeber E.P. Fischer, Piper Verlag, München, Zürich (1991).
13. "Beziehung zwischen Viren und bösartigen Geschwülsten (2): Molekularbiologie der Onkogenese" in
(1991).
14. "Gentherapie durch und von Virusinfektionen", in: Ethik und Gentherapie, Ethik in den Wissenschaften (7),
S. 66-73, Herausgeber C. Rehmann-Sutter, H. Müller, Attempto Verlag Tübingen.
15. "Beziehung zwischen Viren und bösartigen Geschwülsten (2): Molekularbiologie der Onkogenese" in
(1994), 2. Auflage.
16. Moelling K., Nawrath M., Heinrich J., Strack B., Schultz J., Wagner S.N., Pavlovic J.: "Development of a
DNA Vaccine against Malignant Melanoma", in: Molekularbiologie in der Inneren Medizin, Schriftenreihe der
Gesellschaft für Fortschritte in der Inneren Medizin, Georg Thieme Verlag, S. 137-144 (1997).
17. Yoon, K., Jendis, J. and Moelling K.: „RNA and triple helices„ in „Triple Helix-Forming Oligonucleotides„, a
volume of the series „Developments in Antisense research„, ed. C. Malvy and A. Havel-Bellan, Kluver
Academic Publishers, Norwell, MA, La Crosse Virus, Intervirology.
18. Pavlovic, J., Schultz, J., Hefti, H.P., Schuh, T. and Moelling, K.: DNA Vaccination against La Crosse Virus,
Intervirology.
19. Franke D., Pavlovic J., Utesch T.S., von Kleist M., Schultz J., Dollenmaier G., Moelling K. "Update on
Antiviral DNA Vaccine Research (2000-2003)" in: "Novel Vaccination Strategies", ed. S.H.E. Kaufmann,
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, S. 289-317 (2004).
20. Moelling K.: “An den Grenzen des Wissens: Leben Viren?”, Interdisziplinäre Veranstaltungsreihe der
Universität und der ETH Zürich, Zürcher Hochschulforum, Hochschulverlag AG, ETH Zürich (2007)
Co author:
"Denkschrift Parasitologie" DFG, Verlag Chemie, 1989.
"Harrisons Innere Medizin 1,2", 13. Auflage, Deutsche Ausgabe, Blackwell Wissenschafts-Verlag, Berlin (1995) (
2002).
„Springer Lexikon Medizin“, P. Reuter (Hsg.), Springer-Verlag Berlin, Heidelberg, New York, S. 2185-2197
(2004).
Mitverfasserin des Memorandums (1997): Biotechnologie, Gentechnik und wirtschaftliche Innovation, Kapitel
"Forschung und Forschungsförderung". Rat für Forschung, Technologie und Innovation des Bundeskanzlers Dr.
H. Kohl.
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Karin Moelling
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25.9.2010 /
21

Karin Moelling LIST OF PUBLICATIONS

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