HEiKA Research Bridges:

HEiKA Research Bridges: 1 Advanced Imaging Platform (AIP) – (Renamed, before CIP) The AIP establishes an integrated research program on advancing imaging methods including optical, electron and x‐ray modalities. The platform also covers correlative approaches aimed at combining these modalities to extend the structural and temporal information that can be extracted from an individual sample under study. Important aspects in the framework of the “AIP” are technical advances of the various imaging techniques, development of novel contrast agents, advancements of preparation techniques and image data processing software for the different imaging modalities and combinations thereof. HEiKA projects (2013): SCHRÖDER / GENGENBACH, “Automation of serial sectioning, section handling and SEM imaging for large volume 3D reconstruction and array tomography” BISCHOFS / PERNICE, “Spectrally resolved single‐cell imaging with superconducting single‐ photon detectors” HEiKA projects (2015): LEITTE / REISCHL, “Neue Methode zur Feedback‐basierten Segmentierung und Visualisierung von komplexen 3D‐Bilddatensätzen” 2 Medical Technology for Health (MTH) Investigation of medical technologies for health in close cooperation between KIT and Heidelberg University with its two Medical Schools is a focus in this research bridge. It’s the central goal, to join forces and complementary expertise by establishment of laboratories for testing and evaluation of prototypes in the arena of clinical medical technologies and the collaborative execution of translational research projects that rely on innovative systems and methods of medical engineering. HEiKA project (2013): MOMBAUER / ASFOUR, “HEiKA‐EXO ‐ Optimization‐based development and control of an exoskeleton for medical applications” HEiKA projects (2014): SZABÓ / UNTERHINNINGHOFEN, "Rechnergestützte Optimierung der Myokardfunktion nach Herzinfarkt" WUCHTER / GOTTWALD, "Chip‐basierte Mikrobioreaktoren erhalten die Plastizität humaner hämatopoetischer Stammzellen in künstlichen Nischen" MEYER / HEIN, "Technische Unterstützung zur motorischen Aktivierung von Menschen mit beginnender Demenz" Seite 1
3 Natur, Technology and Society (NTS) NTS focuses particularly on interdisciplinary research and trans‐disciplinary reflection of cross‐
sectional questions that transcend the borders between sciences, humanities, social‐ and cultural‐studies. Among the topics that build the scope of NTS research are epistemic, ethical and anthropological questions concerning Bio‐ and Climate engineering, the limits and perspectives of environmental modelling, scenarios of environmental and climate change, and some paradigmatic concepts that are highly relevant e.g. for synthetic biology and systems biology such as life‐ and life‐cycle concepts. The strategic aim of NTS is the improvement of synergy‐potentials between humanities and social sciences in Heidelberg, the Institute for Philosophy and the ITAS at the KIT by shared teaching‐classes, summer schools and scientific cooperation. HEiKA projects (2013): KRUSE / SCHULTZ, “Technische Unterstützung zur kognitiven und sozialen Aktivierung von Menschen mit Demenz“ FUNKE / SCHULTZ, „Combining Statistical and Computational Modeling Approaches for User State Prediction” NÜSSER / KHAZAI, “Integrated Earthquake Risk Assessment for the Himalayan Region (IERA – Himal)” HEiKA projects (2014): EURICH / DECKER, "Technikkompatibilität von Netzwerken in der ambulanten Pflege von Menschen mit Demenz" MEYER / HEIN, "Technische Unterstützung zur motorischen Aktivierung von Menschen mit beginnender Demenz" HEiKA projects (2015): BOBROWSKI / BUTZ, "Accurate prototype remote sensing of correlated carbon and Sulfur emissions from Mount Etna" WITSCHEL / ROBERTSON‐VON TROTHA, "Multidimensional perceptibility of cultural heritage" 4 Organic Electronics Expected are contributions in the field of organic electronics utilizing optimal synergies of research groups at Heidelberg Univeristiy and KIT. The prospects for covering the whole research value chain within the Rhine‐Neckar‐Triangle are of strategic importance in this context (see also leading edge cluster “Forum Organic Electronics” funded by BMBF). The clean room facilities at the InnovationLab as well as the advanced characterization facilities are important elements of the common strategy. The projects should in the long run contribute to the sustainability of the costly research infrastructure of both partners. Seite 2
HEiKA projects (2013): BUNZ / LEMMER, “Verdruckbare konjugierte Polymere (VuKoPo)“ HAMBURGER / MECHAU, „PEDOT 2.0“ HEiKA projects (2014): DREUW / ELSTNER, "Tailored theoretical methods for the Simulation of OE" KOWALSKY / SCHABEL, "Prozess‐Morphologie Zusammenhänge und Strukturaufklärung von Nanoschichten für die OE" HEiKA projects (2015): VAYNZOF / HOWARD, "Fundamental mechanisms of degradation in organic semiconductors and their effect on the Performance of organic photovoltaic devices" MASTALERZ / MECHAU, "Nanoporöse halbleitende Oberflächen als neuartige Sensoren" 5 Synthetic Biology Synthetic Biology is understood as the co‐action of molecular biology, organic chemistry, engineering science, nano bio technology and information technology. The research bridge focusses on the development of new bio materials with functional surfaces, stem cell research and tissue engineering, re‐engineering of signaling as well as modeling and supercomputing. Existing joint work: DFG Forschergruppe FOR1036: “Mechanisms, functions and evolution of Wnt signaling pathways” HEiKA projects (2013): JÄSCHKE / NIENHAUS, “Artificial riboswitches as control elements in synthetic biology” HOLSTEIN / BRÄSE, “On the Roots of Stemness: New tools to study stem cell behaviour and regeneration” HEiKA projects (2014): WITTBRODT / GRABHER, "Quantitative in vivo mapping and Analysis of physiological H2O2 ‐ dependent redox homeostasis in stem cells of the zebrafish central nervous system" ULLRICH / BASTMEYER, "Shaping the heart ‐ structural and functional maturation of stem cell‐derived cardiomyocytes on novel 3D micro‐patterned scaffolds for myocardial repair" WUCHTER / GOTTWALD, "Chip‐basierte Mikrobioreaktoren erhalten die Plastizität humaner hämatopoetischer Stammzellen in künstlichen Nischen" HEiKA projects (2015): DI VENTURA / KASSEL, "Shedding light on myogenesis: Novel optogenetic tools to control muscle progenitor cells differentiation" ÖZBEK / JUNG, "Functional Analysis of TRPN/NOMPC channels and mechanosensation by novel small molecule inhibitors" FRICKER / SCHEPERS, "In vitro reconstruction of dynamic blood brain barrier using µ3DVAsc as an artificial microvascular System" Seite 3