A. Positions and Honors.

BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors.
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NAME
POSITION TITLE
Schreiber, Wolfgang Günther
Professor of Medical Physics
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Ludwig Maximilians-University, Munich, Germany
Ludwig Maximilians-University, Munich, Germany
Ruprecht Karls-University, Heidelberg, Germany
Johannes Gutenberg-University, Mainz, Germay
University of Applied Sciences, Osnabrück,
Germany
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Vordiplom
Diploma
Degree
Dr.rer.nat.
(Ph.D.)
1984-1986
Physics
1986-1990
Physics
Habilitation
2002
MBA
2007
1994
Physics/Magnetic
Resonance
Medical Physics/
Magnetic Resonance
Management of
Science and Higher
Education
A. Positions and Honors.
Positions and Employment
1989-1990
Research Assistant, Max-Planck-Institute for Extraterrestrial Research, Garching, Germany
1991-1994
Research Assistant, German Cancer Research Center, Heidelberg, Germany
1994-1997
Postdoctoral research fellow at the German Cancer Research Center, Heidelberg, Germany
1997-present Head, Medical Physics, Department of Radiology, Mainz University, Germany
2002-2004
Privatdozent (Adjunct Professor) for Medical Physics, Johannes Gutenberg-University, Mainz,
Germany
2004-present Professor of Medical Physics, Johannes Gutenberg-University, Mainz, Germany
Other Experience and Professional Memberships
1994-present Member, International Society for Magnetic Resonance in Medicine
1995-1998
Observer, European Magnetic Resonance Networks in Multiple Sclerosis
1995-present Member, Deutsche Röntgengesellschaft (German Association for Radiology)
1997
Certified Medical Physicist (“Fachanerkennung DGMP”),
1998-2000
Advisory Board, Working Group “Cardiovascular MRI”, German Society for Cardiology
1998-present Member, Editorial Board, Röfo – Forschritte auf dem Gebiet der Röntgenstrahlen
2002
Local Organizing Committee, “Helion02-International Workshop on polarized 3He beams and
gas targets and their applications, Mainz, Germany (September 9-13, 2002)
2002-present Reviewer of the journals Intern J Rad Biol, J Magn Reson, NMR Biomed, J Appl Physiol.
Permanent Reviewer of Magnetic Resonance in Medicine, Journal of Magnetic Resonance
Imaging, Rofo, and Zeitschrifft für Medizinische Physik
2002-present Head, Interdisciplinary Research Group for Functional MRI, Mainz University, Germany
2002-present Member, DGMP (German Society for Medical Physics)
2003-present Program Chair, Annual Symposium on Interdisciplinary Research in Functional MRI, Mainz,
Germany
2004
Program Chair, International Society of Magnetic Resonance in Medicine – German Chapter,
Annual Meeting
2005
Approved Teacher (Weiterbildungsermächtigung DGMP”) for Continuing Education in Medical
Physics
2006-present Advisory Board, DGMP (German Society for Medical Physics)
2007-present PHELINET (Polarized Helium Lung Imaging NETwork): Member Steering Committee, Member
Science Advisory Committee, Head of Research Activity “Helium-3 imaging – Medical
Applications”
2007-present Organizer, German Initiative for Hyperpolarisation (with D. Leibfritz, J. Bernarding)
Awards and Distinctions
1997
Varian Poster Award (German Society for Medical Physics)
1998
Walter-Friedrich Award (German Association for Radiology)
2000
Robert-Müller Research Award (Robert-Müller Foundation for Research in Cardiology and
Angiology)
2001, 2003 Poster Awards (German Association for Radiology)
2003
Poster Award (German Society for Medical Physics)
2006
Innovation Award - Special Award for Innovative Research, Department of Economy, RhinelandPalatinate, Mainz, Germany
B. Selected peer-reviewed publications (in chronological order).
(Publications selected from 72 peer-reviewed publications)
1. W. Schreiber, G. Brix, T. Heß, M.V. Knopp, W.J. Lorenz. IMPROVED VISUALIZATION OF BREAST LESIONS WITH
GADOLINIUM-ENHANCED MAGNETIZATION TRANSFER IMAGING. Magnetic Resonance in Medicine (1996), 35:
861-869
2. H. Hawighorst, W. Schreiber, M.V. Knopp, R. Engenhart-Cabilic, M. Essig, G. Brix, G. van Kaick.
MACROSCOPIC TUMOR VOLUME OF MALIGNANT GLIOMA DETERMINED BY CONTRAST-ENHANCED MAGNETIC
RESONANCE (MR) IMAGING WITH AND WITHOUT MAGNETIZATION TRANSFER (MT) CONTRAST. Magnetic
Resonance Imaging (1996), 14: 1119-1126.
3. H. Hawighorst, M.V. Knopp, W. Schreiber, R. Engenhart-Cabilic, M. Essig, G. Brix, G. van Kaick. MAGNETIC
RESONANCE IMAGING WITH MAGNETIZATION TRANSFER (MT) CONTRAST IN RADIOTHERAPY PLANNING OF
ASTROCYTOMA AND MALIGNANT GLIOMA. Radiaton Therapy and Oncology(1997), 43(3): 261-267.
4. W.G. Schreiber, F. Gückel, P. Stritzke, P. Schmiedek, A. Schwarz, G. Brix. CEREBRAL BLOOD FLOW AND
CEREBROVASCULAR RESERVE CAPACITY: ESTIMATION BY DYNAMIC MAGNETIC RESONANCE IMAGING. Journal of
Cerebral Blood Flow and Metabolism (1998), 18(10): 1143-1156.
5. G. Brix, M.L. Bahner, U. Hoffmann, A. Horvath, W.G. Schreiber. REGIONAL BLOOD FLOW, CAPILLARY
PERMEABILITY, AND COMPARTMENTAL VOLUMES: MEASUREMENT WITH DYNAMIC CT - INITIAL EXPERIENCE.
Radiology (1999), 210: 269-276.
6. I. Berry, G. Barker, F. Barkhof, A. Campi, V. Dousset, J.M. Franconi, A. Gass, W. Schreiber, D. Miller, P.
Tofts. A MULTICENTER MEASUREMENT OF MAGNETIZATION TRANSFER RATIO IN NORMAL WHITE MATTER.
Journal of Magnetic Resonance Imaging (1999), 9: 441-446
7. B. Eberle, N. Weiler, K. Markstaller, R. Surkau, H.-U. Kauczor, W.G. Schreiber, T.P.L. Roberts, W.
Heinrichs, E.W. Otten, M. Thelen. ANALYSIS OF REGIONAL INTRAPULMONARY O2-CONCENTRATIONS BY
MAGNETIC RESONANCE IMAGING OF INHALED HYPERPOLARIZED 3HELIUM. Journal of Applied Physiology
(1999), 87(6): 2043-2052
8. A. Deninger, B. Eberle, T. Grossmann, W. Heil, H.-U. Kauczor, L. Lauer, K. Markstaller, E. Otten, T.P.L.
Roberts, J. Schmiedeskamp, W.G. Schreiber, R. Surkau, N. Weiler. DETERMINATION OF REGIONAL
INTRAPULMONARY OXYGEN DENSITY BY 3HE-MRI. Journal of Magnetic Resonance 141 (1999), 207-216
9. W.G. Schreiber, N. Weiler, H.-U. Kauczor, K. Markstaller, B. Eberle, J. Hast, R. Surkau, T. Großmann, A.
Deninger, G. Hanisch, E.W. Otten, M. Thelen. ULTRASCHNELLE MRT DER LUNGENVENTILATION MITTELS
HOCHPOLARISIERTEM HELIUM-3. Röfo 172 (2000), 129-133
10. D. Guenther, B. Eberle, J. Hast, J. Lill, K. Markstaller, M. Puderbach, W. G. Schreiber, G. Hanisch, C. P.
Heussel, R. Surkau, T. Grossmann, N. Weiler, M. Thelen, H.-U. Kauczor. 3HE MRI IN HEALTHY VOLUNTEERS:
PRELIMINARY CORRELATION WITH SMOKING HISTORY AND LUNG VOLUMES. NMR in Biomedicine 13 (2000) 182189
11. W.G. Schreiber, N. Weiler, K. Markstaller, B. Eberle, A. Scholz, K. Bürger, M. Thelen, H.-U. Kauczor.
ASSESSMENT OF LUNG VENTILATION USING DYNAMIC 19F-MRI OF SULFUR HEXAFLUORIDE (SF6). Magnetic
Resonance in Medicine 45 (2001), 605-613
12. W.G. Schreiber, E.M. Teichmann, I. Schiffer, J. Hast, W. Akbari, H. Georgi, R. Graf, M. Hehn, H.W. Spieß,
M. Thelen, F. Oesch, J.G. Hengstler. LACK OF MUTAGENIC AND CO-MUTAGENIC EFFECTS OF MAGNETIC FIELDS
DURING MAGNETIC RESONANCE IMAGING. Journal of Magnetic Resonance Imaging 14 (2001), 779-788
13. H.-U. Kauczor, K. Markstaller, M. Puderbach, J. Lill, B. Eberle, G. Hanisch, T. Grossmann, C. P. Heussel,
W.G. Schreiber, M. Thelen. VOLUMETRY OF VENTILATED AIRSPACES USING ³HE MRI. Investigative Radiology
36 (2001), 110-114
14. S. Laukemper-Ostendorf, A. Scholz, K. Bürger, C.P. Heussel, M. Schmittner, N. Weiler, K. Markstaller, B.
Eberle, H.-U. Kauczor, M. Quintel, M. Thelen, W.G. Schreiber. 19F-MRI OF PERFLUBRON FOR MEASUREMENT
OF OXYGEN PARTIAL PRESSURE (PO2) IN PORCINE LUNGS DURING PARTIAL LIQUID VENTILATION (PLV). Magnetic
Resonance in Medicine 47 (2002), 82-89
15. J. Hast, I. Schiffer, B. Neugebauer, E. Teichmann, W. Schreiber, J. Brieger, K. Li, M. Strugala, W. Brenner,
F. Oesch, M. Thelen, J. Hengstler. ANGIOGENESIS AND FIBROBLAST PROLIFERATION PRECEDE FORMATION OF
RECURRENT TUMORS AFTER RADIATION THERAPY IN NUDE MICE. Anticancer Research 22 (2002) 677-688
16. S. Hunsche, D. Sauner, W.G. Schreiber, P. Oelkers, P. Stoeter. FAIR AND DYNAMIC SUSCEPTIBILITY
CONTRAST ENHANCED PERFUSION IMAGING IN HEALTHY SUBJECTS AND STROKE PATIENTS. Journal of Magnetic
Resonance Imaging 16 (2002) 137-146
17. K.K. Gast, M.U. Puderbach, I. Rodriguez, B. Eberle, K. Markstaller, A. Hanke, J. Schmiedeskamp, N.
Weiler, J. Lill, W.G. Schreiber, M. Thelen, H.-U. Kauczor. DYNAMIC VENTILATION (3)HE-MAGNETIC
RESONANCE IMAGING WITH LUNG MOTION CORRECTION: GAS FLOW DISTRIBUTION ANALYSIS. Investigative
Radiology 37 (2002) 126-134
18. W.G. Schreiber, M. Schmitt, P. Kalden, O. Mohrs, K.F. Kreitner, M. Thelen. DYNAMIC CONTRAST-ENHANCED
MYOCARDIAL PERFUSION IMAGING USING SATURATION-PREPARED TRUEFISP. Journal of Magnetic Resonance
Imaging 16 (2002), 641-652
19. M. Schmitt, M. Viallon, M. Thelen, W.G. Schreiber. QUANTIFICATION OF MYOCARDIAL BLOOD FLOW AND
BLOOD FLOW RESERVE IN THE PRESENCE OF ARTERIAL DISPERSION: A SIMULATION STUDY. Magnetic
Resonance in Medicine 47 (2002) 787-793
20. S.E. Petersen, T. Voigtländer, K.-F. Kreitner, G. Horstick, S. Ziegler, T. Wittlinger, N. Abegunewardene, M.
Schmitt, W.G. Schreiber, P. Kalden, O.K. Mohrs, R. Lippold, M. Thelen, J. Meyer. LATE IMPROVEMENT OF
REGIONAL WALL MOTION AFTER THE SUBACUTE PHASE OF MYOCARDIAL INFARCTION TREATED BY ACUTE PTCA IN
A 6-MONTH FOLLOW-UP. Journal of Cardiovascular Magnetic Resonance 5 (2003), 487-495
21. S.E. Petersen, G. Horstick, T. Voigtländer, K.-F. Kreitner, T. Wittlinger, S. Ziegler, N. Abegunewardene, M.
Schmitt, W.G. Schreiber, P. Kalden, O.K Mohrs, M. Thelen, J. Meyer. DIAGNOSTIC VALUE OF ROUTINE
CLINICAL PARAMETERS IN ACUTE MYOCARDIAL INFARCTION: A COMPARISON TO DELAYED CONTRAST ENHANCED
MAGNETIC RESONANCE IMAGING. International Journal of Cardiovascular Imaging 19 (2003) 409-416
22. I.B. Schiffer, S. Gebhard, C.K. Heimerdinger, A. Heling, J. Hast, U. Wollscheid, B. Seliger, B. Tanner, S.
Gilbert, T. Beckers, S. Baasner, W. Brenner, C. Spangenberg, D. Prawitt, T. Trost, W.G. Schreiber, B.
Zabel, M. Thelen, H.A. Lehr, F. Oesch, J.G. Hengstler. SWITCHING OFF HER-2/NEU IN A TETRACYCLINECONTROLLED MOUSE TUMOR MODEL LEADS TO APOPTOSIS AND TUMOR-SIZE-DEPENDENT REMISSION. Cancer
Research 63 (2003) 7221-7231
23. S. Ley, J. Zaporozhan, A. Morbach, B. Eberle, K.K. Gast, C.P. Heussel, A. Biedermann, E. Mayer, J.
Schmiedeskamp, A. Stepniak, W.G. Schreiber, H.-U. Kauczor. FUNCTIONAL EVALUATION OF EMPHYSEMA
3
USING DIFFUSION-WEIGHTED
HELIUM-MAGNTIC RESONANCE IMAGING, HIGH-RESOLUCTION COMPUTED
TOMOGRAPHY, AND LUNG FUNCTION TESTS. Investigative Radiology 39, 427-434 (2004)
24. A.E. Morbach, K.K. Gast, J. Schmiedeskamp, A. Dahmen, A. Herweling, C.P. Heussel, H.-U. Kauczor,
W.G. Schreiber. DIFFUSION WEIGHTED MR-IMAGING OF THE LUNG WITH HYPERPOLARIZED HELIUM-3. A STUDY
OF REPRODUCIBILITY. Journal of Magnetic Resonance Imaging 21, 765 – 774 (2005)
25. M. Schmitt, G. Horstick, S.E. Petersen, T.Gumbrich, N. Hoffmann, N. Abegunewardene, W.G. Schreiber.
QUANTIFICATION OF RESTING MYOCARDIAL BLOOD FLOW BASED ON FIRST-PASS MRI: VALIDATION IN A PIG
MODEL OF ACUTE ISCHEMIA. Magnetic Resonance in Medicine 53, 1223 – 1227 (2005)
26. G. J. Barker, W.G. Schreiber, A. Gass, J.P Ranjava, A. Campi, J.H.T.M van Waesberghe, J-M. Franconi,
HC Watt, P.S. Tofts. A STANDARDISED METHOD FOR MEASURING MAGNETISATION TRANSFER RATIO ON MR
IMAGERS FROM DIFFERENT MANUFACTURERS-THE EUROMT SEQUENCE. MAGMA 18, 76-80 (2005)
27. K.K. Gast, W.G. Schreiber, G. Erdös, J. Schmiedeskamp, A. Herweling, A. Stepniak, H.U. Kauczor, B.
Eberle. Two-dimensional and three-dimensional oxygen mapping by 3He-MRI – Validation in a lung
phantom. European Radiology. 15 (2005) 1915 – 1922
28. M. Doebrich, K. Markstaller, J. Karmrodt, H.-U. Kauczor, B. Eberle, N. Weiler, M. Thelen, W.G. Schreiber:
ANALYSIS OF DISCRETE AND CONTINUOUS DISTRIBUTIONS OF VENTILATORY TIME CONSTANTS FROM DYNAMIC
CT Physics in Medicine and Biology 50: 1659-1673 (2005)
29. W.G. Schreiber, A.E. Morbach, T. Stavngaard, K.K. Gast, A. Herweling, L.V. Søgaard, M. Windirsch, J.
Schmiedeskamp, C.P. Heussel, H.-U. Kauczor. Assessment of lung microstructure with magnetic
resonance imaging of hyperpolarized Helium-3. Respiratory Physiology and Neurobiology 148 (2005) 23 42
30. R.H. Acosta, P. Blümler, L. Agulles-Pedrós, A.E. Morbach, J. Schmiedeskamp, A. Herweling, U. Wolf, A.
Scholz, W.G. Schreiber, W. Heil, M. Thelen, H.-W. Spiess. CONTROLLING DIFFUSION OF 3HE BY BUFFER
GASES: A STRUCTURAL CONTRAST AGENT IN LUNG MRI. Journal of Magnetic Resonance Imaging (2006),
1291-1297
31. U. Wolf, A. Scholz, C.P. Heussel, K. Markstaller, W.G. Schreiber. SUBSECOND FLUORINE-19 MRI OF THE
LUNG. Magnetic Resonance in Medicine 55 (2006) 948 – 95
32. A. Pohlmann, M. Möller, H. Decker, W.G. Schreiber. MRI OF TARANTULAS: MORPHOLOGIC AND PERFUSION
IMAGING AT 1.5 TESLAMRI OF TARANTULAS: MORPHOLOGIC AND PERFUSION IMAGING AT 1.5 TESLA. Magnetic
Resonance Imaging (2007) 129 -135
33. W. Weber., A. Kronfeld, R.P. Fiebich, N. Abegunewardene, G. Horstick, K.F. Kreitner, W.G. Schreiber.
COMPARISON OF THREE ACCELERATED PULSE SEQUENCES FOR SEMIQUANTITATIVE MYOCARDIAL PERFUSION
IMAGING USING TSENSE. JMRI26 (2007) 569-579
C. Research Support
Ongoing Research Support
German Research Foundation (DFG) SCHR 687/1
Schreiber (PI)
2001 – 2008
Myocardial Perfusion MRI in Patients with Coronary Artery Disease using a Dedicated Cardiovascular MRI
System
This study is a methodological trial aiming at examining the potential of dedicated cardiovascular MRI systems
for semiquantitative and quantitative myocardial perfusion MRI in patients with cardiovascular disease. It
includes methodological developments (pulse sequences, computational fluid dynamics), animal studies,
volunteer and patient studies.
Role: PI
German Research Foundation (DFG) Schr 687/2
Schreiber (PI)
2002 – 2008
MRI of Pulmonary Microstructure using Hyperpolarised Gases
This is a study aiming at development of methodology for the measurement and assessment of the lung’s
microstructure using hyperpolarised Helium-3 as well as thermally polarized perfluorinated gases.
Role: PI
German Research Foundation (DFG) Schr 687/5
Schreiber (PI)
2006 – 2009)
Optimization of High Frequency Oscillatory Ventilation using Computational Fluid Dynamics and Contrast-gas
based MRI.
This study combines contrast-gas MRI (hyperpolarized Helium-3, thermally polarized perfluorinated gases) and
computational fluid dynamics methods to advance the understanding of gas transport processes as well as
lung protection mechanisms during high frequency oscillatory ventilation.
Role: PI
European Union MRTN-CT-2006-036002
Cremillieux (PI)
2007 - 2009
PHELINET- Polarized Helium Lung Imaging Network
This is an Pan-European Research Project. Its major goal is the advancement of hyperpolarized Helium-3
imaging. It includes subprojects on clinical (Head: Schreiber WG) and preclinical (Head: Cremillieux Y)
applications as well as methodological (Head: Wild J) and Helium-3 polarizer development (Head: Heil W).
Role: Co-Investigator