Enzyme Company Guide 2014 - Bio

Transcription

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Enzyme'Sources'Guide'
Published'by'Sustainable'Chemistry'Solutions,'Inc.'
2014'Edition'
For'regular'updates'on'the'enzyme'industry'sent'directly'to'your'inBbox,'subscribe'to'the'Mainstream'
Biocatalysis'Newsletter:'http://www.bioBcatalyst.com'
Enzyme'industry'information'and'news'you'can'use'
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Introduction'
The!enzyme!market!is!growing!and!changing.!Enzymes!and!biocatalysts!have!become!increasingly!
important!in!a!an!ever:broadening!range!of!applications!that!include!chemicals,!pharmaceuticals,!food!
and!feed,!textiles,!pulp!and!paper,!brewing!and!winemaking,!diagnostics!and!analytics,!molecular!
biology,!detergents,!baking,!and!more.!Some!of!these!applications!have!been!long!served!by!well:known!
enzymes,!but!recent!rapid!advances!in!protein!engineering!and!expression!techniques!have!greatly!
expanded!the!scope!and!usefulness!of!enzymes!in!many!other!contexts.!Particularly!in!chemical!
processing,!enzymes!can!be!engineered!to!fit!process!conditions!using!laboratory!evolution!techniques,!
allowing!biocatalysts!to!replace!chemical!alternatives!in!an!increasingly!wider!range!of!processes.!These!
recent!advances!have!resulted!in!a!growing!number!of!companies,!both!large!and!small,!that!provide!
enzymes!and!enzyme!technology.!!!
New!suppliers!and!developers!of!enzymes!are!entering!the!market,!and!existing!enzyme!companies!are!
expanding!their!offerings!and!capabilities.!Smaller!companies!are!being!acquired!by!larger!ones!(BASF!‘s!
acquisition!of!Verenium!or!Novozymes’!acquisition!of!Allopartis!are!two!recent!examples),!and!large!
companies!are!merging!to!create!even!larger!companies!(for!example:!Genencor:Danisco:DuPont).!
Sustainable!Chemistry!Solutions,!Inc.:!http://www.bio:catalyst.com!!
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Keeping!abreast!of!the!changes!in!the!enzyme!market!is!challenging,!and!knowing!which!company!offers!
competitive!products!in!the!varied!and!changing!competitive!landscape!is!even!tougher.!!
Did!you!know!that!there!are!more!than!240!developers!and!sellers!of!enzymes!around!the!world?!!How!
do!you!know!which!suppliers!to!trust,!which!enzyme!developers!can!best!meet!your!needs?!How!do!you!
contact!them?!Are!you!interested!in!contact!manufacturing!or!custom!enzyme!development?!How!do!
navigate!such!a!rapidly!developing!and!evolving!marketplace?!!
The!Enzyme!Sources!Guide!helps!you!answer!all!these!questions!and!more.!The!information!contained!in!
the!Guide!will!inform!you!about!the!players!in!the!enzyme!industry!and!facilitate!the!search!for!an!
enzyme!provider!or!technology!provider!or!partner!that!meets!your!needs.!!!
The!Enzyme!Sources!Guide!includes!profiles!of!244!companies!that!are!developers,!manufacturers!or!
suppliers!of!enzymes;!these!companies!span!the!range!from!large!established!multi:national!
corporations!with!many!enzyme!offerings!to!small!start:up!companies!providing!a!handful!of!enzymes!in!
relatively!small!amounts.!!The!guide!is!comprehensive!and!covers!enzyme!companies!worldwide.!!The!
selection!criteria!for!company!inclusion!required!that!a!company!is!a!seller!or!developer!of!enzyme!
products!or!a!provider!enzyme!research!or!manufacturing!services.!Developers!and!suppliers!of!enzymes!
for!industrial,!animal!feed,!food!and!beverage!processing!are!included,!along!with!suppliers!of!enzymes!
for!biocatalysis,!research,!diagnostics,!and!life!sciences!applications.!
Looking!for!a!commercially:stable!supplier!of!lipases?!The!Enzyme!Sources!Guide!lists!suppliers!from!
around!the!world!and!tells!you!the!size!of!the!company!and!how!long!that!company!has!been!in!
business.!
Need!a!conveniently!located!supplier!of!a!range!of!different!enzymes!for!biocatalysis?!The!Enzyme!
Sources!Guide!shows!you!all!the!suppliers!of!enzymes!for!biocatalysis!and!their!product!lines,!listed!by!
geographical!region,!so!that!you!can!find!the!most!convenient!provider,!no!matter!where!your!business!
is!located.!
Interested!in!identifying!a!contract!research!partner?!The!Enzyme!Sources!Guide!tells!you!which!enzyme!
developers!also!offer!contract!research!services.!
Need!to!find!a!contract!manufacturer!for!an!enzyme?!The!Enzyme!Sources!Guide!has!a!listing!of!contract!
manufacturers!for!enzymes!around!the!world.!The!Enzymes!Sources!Guide!also!contains!profiles!of!all!
the!companies!so!that!you!can!more!quickly!identify!the!best!supplier!for!your!enzyme!needs.!
Looking!for!immobilized!enzymes?!A!comprehensive!list!of!companies!supplying!immobilized!enzymes,!
support!materials,!and!immobilization!technology!is!included.!
 The!Enzyme!Sources!Guide!will!give!you!actionable!information!on!enzyme!suppliers!around!the!
world!so!that!you!will!save!time!in!sourcing!enzymes!and!biocatalysis!partners.!
 The!Enzyme!Sources!Guide!is!the!only!comprehensive!listing!of!more!than!200!enzyme!suppliers!
around!the!world!so!that!you!can!identify!all!options!for!enzyme!supply,!not!just!a!few.!
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 The!Enzyme!Sources!Guide!breaks!down!enzyme!suppliers!around!the!world!so!that!you!can!
easily!locate!the!supplier!nearest!your!location,!most!convenient!!
 The!Enzyme!Sources!Guide!breaks!down!enzyme!suppliers!around!the!world!so!that!you!can!
easily!identify!the!most!conveniently!located!providers.!
 The!Enzyme!Sources!Guide!lists!all!the!suppliers!of!immobilized!enzymes!so!that!so!can!quickly!
identify!a!supplier!for!immobilized!biocatalysts.!
Each!company!profile!provides!an!overview!of!each!company’s!offerings,!history,!size,!financial!heath,!
technology,!and!R!&!D!capabilities.!!This!information!was!gathered!mostly!from!public!sources!including!
regulatory!filings,!published!scientific!articles,!patents,!press!articles,!company!websites,!public!
presentations,!and!similarly!available!sources.!!In!some!cases,!the!companies!themselves!provided!us!
with!additional!information!via!interviews!or!other!communication.!!!
In!addition,!Tables!list!enzyme!companies!by!geographical!location,!enzyme!market,!and!specialization.!
A!separate!section!listing!150+!enzyme!distributors!around!the!world!is!also!included.!
We!hope!you!will!find!the!Enzyme!Sources!Guide!to!be!an!indispensable!resource!and!information!
source!about!companies!in!the!enzyme!industry.!
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Disclaimer:!We!have!tried!to!insure!that!the!information!provided!here!is!accurate!as!of!the!date!of!
publication,!but!the!enzyme!market!is!rapidly!changing.!Some!recent!changes!in!companies!and!product!
lines!may!not!be!incorporated!here,!and!we!cannot!guarantee!that!some!innacuracies!may!be!present.!
This!guide!is!not!intended!to!be,!and!should!not!be!construed!as,!legal!or!financial!advice.!!!
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Copyright!©!2014!by!Sustainable!Chemistry!Solutions,!Inc.!
Copying!or!redistribution!of!this!publication!is!forbidden!by!law.!!
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Table'of'Contents'
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Table!1:!Companies!Classified!by!Types!of!Enzymes!Produced!or!Sold!!………………….………….……….…!!5:13!
Table!2:!Companies!Classified!as!Manufacturers,!Distributors,!and!Service!Providers!………….….…..!14:24!
Table!3:!Enzyme!Companies!Offering!Immobilized!Enzymes,!Materials,!Services!………………………………!25!
Table!4:!Enzyme!Companies!Listed!According!Geographical!Location!or!Sales!Region!……………….…!26:40!
Profiles!of!Enzyme!Companies!Worldwide,!Listed!Alphabetically!…………………………………………………!41:414!
Distributors!of!Animal!Feed!Enzymes!World:wide!………………………………………………………………..…..!415:448!
Distributors!of!Life!Science!Enzymes!World:wide!……………….…………………………………………………….!449:465!
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Molecular!Biology!
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Other!
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Carbohydrates!
x'
Leather!
x'
Diagnostic!and!
Analytical!
x'
Oil!Field!
Winemaking!and!
Brewing!
x'
Animal!feed!
Food,!Baking,!and!
Juices!
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Pulp!and!Paper!
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Textiles!and!
Detergents!
AB!Enzymes!
AB!Vista!
Acore!Pharmatech!
Actygea!
Addiseo!
Advanced!Enzyme!
Technologies,!Ltd.!
Agrimex!
Ajinomoto!
Aldevron!
Alea!Evolution!
Alfa!Kimya!Company!
AlfaNzyme!Bio:Tech!
Alliance!Enzyme!Pvt!
Ltd!
Alltech!USA!
Almac!Sciences!
Alpha!Diagnostic!
International!
Amano!Enzyme!Co.!
Ltd.!
American!Biosystems!
American!
Laboratories,!Inc!
Americos!Industries!
Inc!
Amit!Biotech!Pvt.!Ltd.!
AMPLICON!
Ampliqon!A/S!
ANC!Enzymes!
Andrés!Pintaluba,!
S.A.!!!!!
Anil!Bioplus!
Anthem!Cellutions!
Apollo!Chemical!
Company!
Biocatalysts!
Company!
Table'1:'Companies'Categorzed'by'Types'of'Enzymes'Produced/Sold'
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Molecular!Biology!
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Other!
Oil!Field!
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Carbohydrates!
Animal!feed!
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Leather!
Winemaking!and!
Brewing!
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Diagnostic!and!
Analytical!
Food,!Baking,!and!
Juices!
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Textiles!and!
Detergents!
Pulp!and!Paper!
Apollo!Scientific!
Applied!
Biotechnology!
Institute!
Archaenzyme!Ltd!
ArcticZymes!
Ares!Bioscience!
GmbH!(Genecraft)!
Arun!and!Co!
ASA!Spezialenzyme!
GmbH!
Asahi!Kasei!Pharma!
AUMEnzymes!
Aumgene!
BASF!!
BBI!Enzymes!
BehnMeyer!
Beldem!
Berg!+!Schmidt!
GmbH!&!Co.!KG!
Bergerow!
Berlin!Chemical!
BiCT!srl!
BIO:CAT!
Biocat!Collection!
Biocatalysts!Ltd.!
Biochem!
Biomin!
BIO:PORT!Europe!
s.r.o.!
BioPox!
Biorbyt!Ltd.!!
BioResearch!
Products!
Bioron!GmbH!
Biocatalysts!
Company!
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Carbohydrates!
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Leather!
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Diagnostic!and!
Analytical!
x'
Oil!Field!
Animal!feed!
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Winemaking!and!
Brewing!
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Food,!Baking,!and!
Juices!
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Pulp!and!Paper!
Textiles!and!
Detergents!
Bioseutica!
BioSphere!
biovet!
Biozym!
BioZyme!
BRAIN!AG!
Brenntag!
BSC!Biochemicals!
C.Schliessmann!
C5.6!Technologies!
Calzyme!
Cambrex!IEP!GmbH!
Cellectis!SA!
Centerchem!
Chematics!
CHEMOS!GmbH!
Chimab!
Chiral!Vision!
Chr.!Hansen!
CHT/BEZEMA!
CLEA!Technologies!
c:LEcta!GmbH!
Codexis,!Inc.!
Colotex!Company!Ltd!
Concord!Biotech!
Condor!Specialty!
Products!
CPC!Biotech!
Creative!BioMart!
Deltagen!Bioproducts!
N.A.!
Direvo!Industrial!
Biotechnology!GmbH!
Discovery!
Biocatalysts!
Biocatalysts!
Company!
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7!
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Pulp!and!Paper!
Food,!Baking,!and!
Juices!
Winemaking!and!
Brewing!
Animal!feed!
Oil!Field!
Diagnostic!and!
Analytical!
Leather!
Carbohydrates!
Other!
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Molecular!Biology!
Textiles!and!
Detergents!
DNA!Polymerase!
Technology!Inc.!
Dong!Nam!Chemicals!
&!Equipments!
Corporation!
DSM!
DuPont!(Danisco:
Genencor)!
Dyadic!
DyStar!
Elanco!(Chem!Gen)!
elementalenzymes!
EMELCA!Bioscience!
Emp!Biotech!GmbH!
Enantis!
Enartis!Vinquiry!
Engrain!
ENGroup!
EnMex!SA!DE!CV!
Enzagen!
Enzybel!International!
Enzymatic!Deinking!
Technologies,!LLC!
Enzymatics!
Enzyme!
Development!
Corporation!
Enzyme!Solutions!
Enzyme!Solutions!
(USA)!
Enzyme!Supplies!
EnzymeKing!
Biotechnology!Co.!
Ltd!
Enzymes!Naveen!
EnzymeWorks!
Biocatalysts!
Company!
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8!
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Winemaking!and!
Brewing!
Animal!feed!
Oil!Field!
Diagnostic!and!
Analytical!
Leather!
Carbohydrates!
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Molecular!Biology!
Food,!Baking,!and!
Juices!
'
Enzymicals!AG!
Enzymology!Research!
Center!Inc!
Enzyvia!LLC!
epicentre!
epygen!
ERA!Biotech!
Erbsloh!Geisenheim!
AG!
Eucodis!Biosciences!
GmbH!
Evocatal!GmbH!
Fenkin!Kimya!Sanayi!
Ve!Ticaret!Ltd!
Fermenta!Biotech!Ltd!
Fermentia!
Fytozimus!
Galilaeus!Oy!
Genkim!
GenScript!USA!Inc!
GNCBioferm!
Habio!Bioengineering!
(Sichuan)!
Huvepharma!
IBEX!
Imperial!Jade!Bio:
Technology!Co.,!Ltd.!
Infinite!Enymzes!
InnoTech!MSU!
Iris!Biotech!GmbH!
Jena!Bioscience!
GmbH!
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Bioproducts!Co.!Ltd!
Jiangsu!OGO!Biotech!
Co.,!Ltd.!
Other!
Pulp!and!Paper!
'
Biocatalysts!
'
Company!
Textiles!and!
Detergents!
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9!
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!!
Oil!Field!
Diagnostic!and!
Analytical!
Leather!
Carbohydrates!
Other!
Molecular!Biology!
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Animal!feed!
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Winemaking!and!
Brewing!
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Food,!Baking,!and!
Juices!
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Pulp!and!Paper!
'
Textiles!and!
Detergents!
Jinan!Tiantianxiang!
Co.,!Ltd.!
Johnson!Matthey!
Kemikalia!
Kemin!
Kerry!Americas!
Kiotechagil!
Kiwienzyme.com!Ltd!
Lactosan!GmbH!
Laffort!
Lallemand!
Lamothe:Abiet!
Lanxess!
Larbus!s.a.!
Lentikats!
Biotechnologies!
Leveking!Enzymes!
Libragen!
Life!Technologies!
(GeneArt)!
Lonza!
Lucigen!
Lumis!Biotech!
Lybradyn!
Lyven!
M!L!CHEMICALS!
(INDIA)!PVT!LTD.!
Maps!Enzyme!
Limited!
Megazyme!Ireland!
Meito!Sangyo!
Menlo!
Biotech/Ecozymes!
Merck!KGaA!(EMD!
Millipore,!
Calbiochem)!
Biocatalysts!
Company!
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10!
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!!
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Other!
Molecular!Biology!
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Carbohydrates!
Oil!Field!
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Leather!
Animal!feed!
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Diagnostic!and!
Analytical!
Winemaking!and!
Brewing!
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Food,!Baking,!and!
Juices!
x'
Pulp!and!Paper!
Biocatalysts!
Metabomics!
Metgen!Oy!
Millbo!
Mirpain!
Mühlenchemie!
MP!Biomedical!
Nagase!
Najing!Chemlin!
Chemical!Industry!
NEB!
Nordmann,!
Rassmann!
Novozymes!
Novus!
Nutreco!
Nzomics!Biocatalysis!
NZYTech!
OenoBioTech!SAS!
Oenobrands!
OptiGene!
ORBA!
Oriental!Yeast!
Parchem!
Prochimica!Group!
Proenzimas!Ltda!
Promega!
Protean!
Proteogen!Bio!
Prozomix!
Prozyme!
Purolite!
Research!Products!
Company!
Roal!Oy!
RobinsonBioproducts!
Textiles!and!
Detergents!
Company!
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11!
!
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!!
Oil!Field!
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Molecular!Biology!
Animal!feed!
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Other!
Winemaking!and!
Brewing!
'
x'
Carbohydrates!
Food,!Baking,!and!
Juices!
'
x'
Leather!
Pulp!and!Paper!
'
'
Diagnostic!and!
Analytical!
Textiles!and!
Detergents!
Roche!
Rossari!Biotech!
S!I!CHEMICAL!
INDUSTRIES!
Sartoris!Stedim!
Biotech!
Scott!Laboratories!
Season!Chemicals!
Dyestuffs!
Sekisui!Enzymes!
Senson!Ltd!
Shandong!Longda!
Bio:Products!Co.,!Ltd.!
SHIN!NIHON!
CHEMICAL!CO.,!LTD.!
SibEnzyme!
Sigma:Aldrich!
SinoBios!!
Specialty!Enzymes!
and!Biotechnologies!
Inc.!
SpheriTech!
Sprin!
SternEnzym!
Strem!
Sukahan!
Sunson!Industry!
Group!Company!
Limited!
SynBioCat!Ltd!
Syncozymes!
Takabio!
tebu:bio!
Tegaferm!
Tex!Biosciences!
The!Seydel!
Biocatalysts!
Company!
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12!
!
!
!!
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Carbohydrates!
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Leather!
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Diagnostic!and!
Analytical!
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Textiles!and!
Detergents!
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Molecular!Biology!
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Other!
x'
Oil!Field!
x'
Animal!feed!
Food,!Baking,!and!
Juices!
'
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Winemaking!and!
Brewing!
Pulp!and!Paper!
'
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Biocatalysts!
Company!
Companies!
ThermoFisher!
Toyobo!Enzymes!
TransBiodiesel!
Tri:Tex!Co!
Ultra!Bio:Logics!Inc.!
Unikbio!
Biotech(Guangzhou)!
Ltd!
Unitaka!
VEMO!99!Ltd!!
Verenium!
Veskim!
W42!Industrial!
Biotechnology!GmbH!
Wako!Pure!Chemical!
Industries!
Weiss!Biotech!GmbH!
Worthington!
Yakult!
Zymetech!
Zytex!
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13!
!
!
!!
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USA!
Italy!
France!
www.acorePharmatech.com!!
www.actygea.com!!
www.adisseo.com!!
'
India!
Belgium!
Japan!
USA!
Italy!
www.advancedenzymes.co
m!!
www.agrimex.be!!
www.ajinomoto.com!!
www.aldevron.com!!
www.alea:evolution.com!!
Turkey!
www.en.alfakimya.com!!!!!
'
India!
www.alfanzymebiotech.com!!
'
India!
USA!
UK!
www.papainenzyme.com!!
www.alltech.com!!
www.almacgroup.com!!
USA!
www.4adi.com!!
Japan!
USA!
www.amano:enzyme.co.jp!!
www.americanbiosystems.c
om!!
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USA!
www.americanlaboratories.
com!!
India!
www.kenencoregroup.com!!
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India!
www.amitbiotech.com!!
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!
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Contract!
Research!
Service!
www.abenzymes.com!!
www.abvista.com!!
Contract!
Manufacturer!
Primary!
Manufacturer!
Germany!
UK!
Distributor!
AB!Enzymes!
AB!Vista!
Acore!
Pharmatech!
Actygea!
Addiseo!
Advanced!
Enzyme!
Technologies,!
Ltd.!
Agrimex!
Ajinomoto!
Aldevron!
Alea!Evolution!
Alfa!Kimya!
Company!
AlfaNzyme!Bio:
Tech!
Alliance!Enzyme
!Pvt!Ltd!
Alltech!USA!
Almac!Sciences!
Alpha!
Diagnostic!
International!
Amano!Enzyme!
Co.!Ltd.!
American!
Biosystems!
American!
Laboratories,!
Inc!
Americos!
Industries!Inc!
Amit!Biotech!
Pvt.!Ltd.!
Website!
Company!
Headquarters!
Table'2:'Classification'as'Manufacturers,'Distributors,'Service'Providers'
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14!
!
!
!!
www.pintaluba.com!!
www.anilbioplus.com!!
India!
www.anthemcell.com!!
USA!
UK!
www.apollochemical.com!!
www.apolloscientific.co.uk!!
USA!
www.appliedbiotech.org!!
Israel!
Norway!
www.archaezyme.com!!
www.arcticzymes.com!!!
www.genecraft.de!!
www.arunandco.com!!
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www.asa:enzyme.de!!
Japan!
India!
India!
Germany!
UK!
Germany!
Belgium!
www.asahi:kasei.com!!
www.aumenzymes.com!!
www.aumgene.com!!
www.basf.com!!
www.bbienzymes.com!!
www.behnmeyer.com!!
www.beldem.com!!
Germany!
Germany!
China!
Italy!
www.berg:schmidt.de!!
www.begerow.com!!
www.berlinchem.com!!
www.bict.it!!
!
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Distributor!
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Germany!
Contract!
Research!
Service!
www.ampliqon.com!!
www.ancenzymes.com!!
Spain!
India!
Germany!
India!
Primary!
Manufacturer!
www.amplicon.cz!!
Contract!
Manufacturer!
AMPLICON!
Ampliqon!A/S!
ANC!Enzymes!
Andrés!
Pintaluba,!S.A.!!!!!
Anil!Bioplus!
Anthem!
Cellutions!
Apollo!Chemical!
Company!
Apollo!Scientific!
Applied!
Biotechnology!
Institute!
Archaenzyme!
Ltd!
ArcticZymes!
Ares!Bioscience!
GmbH!
(Genecraft)!
Arun!and!Co!
ASA!
Spezialenzyme!
GmbH!
Asahi!Kasei!
Pharma!
AUMEnzymes!
Aumgene!
BASF!!
BBI!Enzymes!
BehnMeyer!
Beldem!
Berg!+!Schmidt!
GmbH!&!Co.!KG!
Bergerow!
Berlin!Chemical!
BiCT!srl!
Czech!
Republic!
Denmark!
Singapore!
Website!
Company!
Headquarters!
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15!
!
!
!!
Germany!
UK!
Germany!
Austria!
Czech!
Republic!
Italy!
UK!
www.biocatcollection.net!!
www.biocatalysts.com!!!!
www.biochem.net!!
www.biomin.net!!
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www.bio:port.cz!!!!
www.biopox.com!!
www.biorbyt.com!!
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USA!
Germany!
Netherlands!
Italy!
Bulgaria!
Germany!
Romania!
Germany!
Germany!
www.bio:researchprod.com!!
www.bioron.net!!
www.bioseutica.com!!
www.biospheresrl.com!!
www.biovet.com!!
www.biozym.com!!!!
www.biozyme.ro!!!
www.brain:biotech.de!!
www.brenntag.com!!
!Belgium!
Germany!
www.bscbio.be!!
www.c:schliessmann.de!!
USA!
USA!
www.c56technologies.com!!!!
www.calzyme.com!!
USA!
France!
USA!
USA!
Germany!
Italy!
Netherlands!
Denmark!
Germany!
www.cambrex.com!!
www.cellectis.com!!
www.centerchem.com!!
www.chematics.com!!
www.chemos:group.com!!
www.chimab.it!!
www.chiralvision.com!!
www.chr:hansen.com!!
www.cht:group.com!!
!
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Contract!
Research!
Service!
www.bio:cat.com!!
Distributor!
Primary!
Manufacturer!
USA!
Contract!
Manufacturer!
BIO:CAT!
Biocat!
Collection!
Biocatalysts!Ltd.!
Biochem!
Biomin!
BIO:PORT!
Europe!s.r.o.!
BioPox!
Biorbyt!Ltd.!!
BioResearch!
Products!
Bioron!GmbH!
Bioseutica!
BioSphere!
biovet!
Biozym!
BioZyme!
BRAIN!AG!
Brenntag!
BSC!
Biochemicals!
C.Schliessmann!
C5.6!
Technologies!
Calzyme!
Cambrex!IEP!
GmbH!
Cellectis!SA!
Centerchem!
Chematics!
CHEMOS!GmbH!
Chimab!
Chiral!Vision!
Chr.!Hansen!
CHT/BEZEMA!
Website!
Company!
Headquarters!
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16!
!
!
!!
CLEA!
Technologies!
c:LEcta!GmbH!
Codexis,!Inc.!
Colotex!
Company!Ltd!
Concord!
Biotech!
Condor!
Specialty!
Products!
CPC!Biotech!
Creative!
BioMart!
Deltagen!
Bioproducts!
N.A.!
Direvo!
Industrial!
Biotechnology!
GmbH!
Discovery!
Biocatalysts!
DNA!
Polymerase!
Technology!Inc.!
Dong!Nam!
Chemicals!&!
Equipments!
Corporation!
DSM!
DuPont!
(Danisco:
Genencor)!
Dyadic!
DyStar!
Elanco!(Chem!
Gen)!
elementalenzy
Netherlands! www.cleatechnologies.com!!
Germany!
www.c:lecta.com!!
USA!
www.codexis.com!!
Hong!Kong!
www.colotexbiotech.com!!
India!
www.concordbiotech.com!!
USA!
Italy!
www.condorspecialty.com!!
www.cpcbiotech.it!!
USA!
www.creativebiomart.net!!
Netherlands!
Antilles!
www.deltagenbiop.com!!!
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Germany!
www.direvo.com!!
UK!
www.discovery:bc.co.uk!!
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USA!
www.klentaq.com!!
'
Vietnam!
www.dongnamlab.com!!
Netherlands! www.dsm.com!!
x'
x'
USA!
USA!
Germany!
www.dupont.com!!
www.dyadic.com!!!
www.dystar.com!!
USA!
USA!
www.elanco.us!!
www.elementalenzymes.co
!
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Contract!
Research!
Service!
Contract!
Manufacturer!
Distributor!
Primary!
Manufacturer!
Website!
Company!
Headquarters!
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17!
!
!
!!
Contract!
Research!
Service!
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x'
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Distributor!
Primary!
Manufacturer!
Website!
Contract!
Manufacturer!
mes!
EMELCA!
Bioscience!
Emp!Biotech!
GmbH!
Headquarters!
Company!
m!!
Belgium!
Germany!
Czech!
Enantis!
Republic!
Enartis!Vinquiry! Italy!
Engrain!
USA!
ENGroup!
China!
EnMex!SA!DE!
CV!
Mexico!
Enzagen!
UK!
Enzybel!
International!
!Belgium!
Enzymatic!
Deinking!
Technologies,!
LLC!
USA!
Enzymatics!
USA!
Enzyme!
Development!
Corporation!
USA!
Enzyme!
Solutions!
Australia!
Enzyme!
Solutions!(USA)! USA!
Enzyme!
Supplies!
UK!
EnzymeKing!
Biotechnology!
Co.!Ltd!
China!
Enzymes!
Naveen!
India!
EnzymeWorks!
China!
Enzymicals!AG!
Germany!
Enzymology!
Research!
Center!Inc!
USA!
www.emelcabio.com!!!
www.empbiotech.com!!
www.enantis.com!!
www.enartis.com!!
www.engrain.us!!
www.engroup.cn!!
www.enzymes.com.mx!!
www.enzagen.com!
www.enzybel.com!!
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www.edt:enzymes.com!!
www.enzymatics.com!!
www.EnzymeDevelopment.
com!!
www.enzymesolutions.com.
au!!
www.enzymesolutions.com!!
www.enzymesupplies.com!!
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www.enzymeking.com!!
!!
www.enzymeworking.com!!
www.enzymicals.com!!!
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www.ercenzymes.com!!
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18!
!
!
!!
Enzyvia!LLC!
epicentre!
epygen!
ERA!Biotech!
Erbsloh!
Geisenheim!AG!
Eucodis!
Biosciences!
GmbH!
Evocatal!GmbH!
Fenkin!Kimya!
Sanayi!Ve!
Ticaret!Ltd!
Fermenta!
Biotech!Ltd!
Fermentia!
Fytozimus!
Galilaeus!Oy!
Genkim!
GenScript!USA!
Inc!
GNCBioferm!
Habio!
Bioengineering!
Huvepharma!
IBEX!
Imperial!Jade!
Bio:Technology!
Co.,!Ltd.!
Infinite!
Enymzes!
InnoTech!MSU!
Iris!Biotech!
GmbH!
Jena!Bioscience!
GmbH!
Jiangsu!Boli!
Bioproducts!Co.!
USA!
USA!
UAE!
Spain!
www.enzyvia.com!!
www.epibio.com!!
www.epygen.com!!
www.erabiotech.com!!
Germany!
www.erbsloeh.com!!
Austria!
Germany!
www.eucodis.com!!
www.evocatal.com!!
Turkey!
www.fenkim.com!!
India!
Hungary!
Canada!
Finland!
Turkey!
www.fermentabiotech.com!!
www.fermentia.eu!!
www.fytozimus.com!!
www.galilaeus.fi!!
www.genkim.com.tr!!
USA!
Canada!
www.genscript.com!!
www.gncbioferm.ca!!
Bulgaria!
Bulgaria!
Canada!
www.habio.net!!
www.huvepharma.com!!
www.ibex.ca!!
China!
www.imperialjade12.en.chi
na.cn!!
USA!
Russia!
www.infiniteenzymes.com!!!
www.innotech:msu.com!!
Germany!
www.iris:biotech.de!!
Germany!
www.jenabioscience.com!!
China!
www.bolibio.com!!
!
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Contract!
Research!
Service!
Contract!
Manufacturer!
Distributor!
Primary!
Manufacturer!
Website!
Headquarters!
Company!
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19!
!
!
!!
www.ogo:biotech.com!!
China!
www.jnttx.com!!
UK!
Sweden!
USA!
USA!
UK!
New!
Zealand!
Austria!
France!
Canada!
France!
Germany!
Spain!
Czech!
Republic!
www.jmcct.com!!
www.kemikalia.se!!
www.kemin.com!!
www.kerry.com!!
www.kiotechagil.com!!
China!
France!
www.levekingenzymes.com!!
www.libragen.com!!
USA!
Switzerland!
USA!
Inda!
USA!
!France!
www.lifetechnologies.com!!
www.lonza.com!!
www.lucigen.com!!!
www.lumisbiotech.com!!
www.lybradyn.com!!
www.lyven.com!!
x'
www.kiwienzyme.com!!
www.lactosan.at!!
www.laffort.com!!
www.lallemand.com!!
www.lamothe:abiet.com!!
www.lanxess.com!!!!
www.larbus.com!!
www.lentikats.eu!!
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www.mlindia.com!!
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India!
Contract!
Research!
Service!
China!
Contract!
Manufacturer!
Primary!
Manufacturer!
Website!
x'
Distributor!
Ltd!
Jiangsu!OGO!
Biotech!Co.,!
Ltd.!
Jinan!
Tiantianxiang!
Co.,!Ltd.!
Johnson!
Matthey!
Kemikalia!
Kemin!
Kerry!Americas!
Kiotechagil!
Kiwienzyme.co
m!Ltd!
Lactosan!GmbH!
Laffort!
Lallemand!
Lamothe:Abiet!
Lanxess!
Larbus!s.a.!
Lentikats!
Biotechnologies!
Leveking!
Enzymes!
Libragen!
Life!
Technologies!
(GeneArt)!
Lonza!
Lucigen!
Lumis!Biotech!
Lybradyn!
Lyven!
M!L!CHEMICALS!
(INDIA)!PVT!
LTD.!
Headquarters!
Company!
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20!
!
!
!!
Ireland!
Japan!
www.megazyme.com!!
www5.mediagalaxy.co.jp/m
eito/kaseihin/index_e.html!!!
UK!
www.menlobiotech.com!!!!
Germany!
China!
Finland!
Italy!
Turkey!
Germany!
USA!
Japan!
Primary!
Manufacturer!
www.emdgroup.com!!
www.metabomics.com!!
www.metgen.fi!!
www.millbo.com!!
www.mirpain.com!!
www.muehlenchemie.de!!
www.mpbio.com!!
www.nagasechemtex.co.jp!!
www.chemlin.guidechem.co
m!!
www.neb.com!!
www.nordmann:
Germany!
rassmann.com!!
Denmark!
www.novozymes.com!!
USA!
www.novusint.com!!
Netherlands! www.nutreco.com!!!!!
China!
USA!
UK!
Portugal!
www.nzomics.com!!
www.nzytech.com!!
France!
France!
UK!
Turkey!
Japan!
www.oenobiotech.com!!
www.oenobrands.com!!
www.optigene.co.uk!!
www.orba.com.tr!!
www.oyc.co.jp!!
!
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Contract!
Research!
Service!
www.mapsenzymes.com!!
Contract!
Manufacturer!
Meito!Sangyo!
Menlo!
Biotech/Ecozym
es!
Merck!KGaA!
(EMD!Millipore,!
Calbiochem)!
Metabomics!
Metgen!Oy!
Millbo!
Mirpain!
Mühlenchemie!
MP!Biomedical!
Nagase!
Najing!Chemlin!
Chemical!
Industry!
NEB!
Nordmann,!
Rassmann!
Novozymes!
Novus!
Nutreco!
Nzomics!
Biocatalysis!
NZYTech!
OenoBioTech!
SAS!
Oenobrands!
OptiGene!
ORBA!
Oriental!Yeast!
India!
Distributor!
Maps!Enzyme!
Limited!
Megazyme!
Ireland!
Website!
Company!
Headquarters!
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21!
!
!
!!
Protean!
Proteogen!Bio!
Prozomix!
Prozyme!
Purolite!
Research!
Products!
Company!
Roal!Oy!
RobinsonBiopro
ducts!
Roche!
Rossari!Biotech!
S!I!CHEMICAL!
INDUSTRIES!
Sartoris!Stedim!
Biotech!
Scott!
Laboratories!
Season!
Chemicals!
Dyestuffs!
Sekisui!Enzymes!
Senson!Ltd!
Shandong!
Longda!Bio:
Products!Co.,!
Ltd.!
SHIN!NIHON!
CHEMICAL!CO.,!
LTD.!
Italy!
www.prochimicagroup.com!!
'
Columbia!
USA!
Czech!
Republic!
Italy!
UK!
USA!
USA!
www.proenzimas.com!!
www.promega.com!!
'
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USA!
Finland!
www.protean.cz!!
www.proteogenbio.com!!
www.prozomix.com!!
www.prozyme.com!!
www.purolite.com!!!
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Canada!
Switzerland!
India!
www.researchprod.com!!!
www.roal.fi!!
www.robinsonbioproducts.c
om!!
www.roche.com!!
www.rossari.com!!
India!
www.papain.in!!
France!
www.sartorius:stedim.com!!
'
USA!
www.scottlab.com!!
'
Hong!Kong!
UK!
Finland!
www.sesaonchemicals.com!!
www.sekisuienzymes.com!!
www.senson.fi!!
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China!
Japan!
www.enzymeinchina.com!!
www.aichi:
brand.jp/corporate/type/ch
emical/shin:nihon:e.html!!
!
x'
x'
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x'
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Contract!
Research!
Service!
www.parchem.com!!
Distributor!
Primary!
Manufacturer!
USA!
Contract!
Manufacturer!
Parchem!
Prochimica!
Group!
Proenzimas!
Ltda!
Promega!
Website!
Company!
Headquarters!
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'
22!
!
!
!!
Primary!
Manufacturer!
www.specialtyenzymes.com!!
www.spheritech.com!!
www.sprintechnologies.com!!
www.sternenzym.de!!
www.strem.com!!
www.sukahan.com!!
Contract!
Research!
Service!
USA!
UK!
Italy!
Germany!
USA!
China!
www.sibenzyme.com!!
www.sigmaaldrich.com!!
www.sinobios.com!!
Contract!
Manufacturer!
Russia!
USA!
China!
Distributor!
SibEnzyme!
Sigma:Aldrich!
SinoBios!!
Specialty!
Enzymes!and!
Biotechnologies!
Inc.!
SpheriTech!
Sprin!
SternEnzym!
Strem!
Sukahan!
Sunson!Industry!
Group!
Company!
Limited!
SynBioCat!Ltd!
Syncozymes!
Takabio!
tebu:bio!
Tegaferm!
Tex!Biosciences!
The!Seydel!
Companies!
ThermoFisher!
Toyobo!
Enzymes!
TransBiodiesel!
Tri:Tex!Co!
Ultra!Bio:Logics!
Inc.!
Unikbio!
Biotech(Guangz
hou)!Ltd!
Unitaka!
VEMO!99!Ltd!!
Verenium!
Website!
Company!
Headquarters!
'
x'
'
x'
x'
'
'
'
'
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'
x'
x'
'
x'
x'
'
'
x'
x'
x'
'
x'
x'
China!
Hungary!
China!
France!
France!
Austrial!
India!
www.chinaenzymes.com!!
www.synbiocat.hu!!
www.syncozymes.com!!
www.takabio.com!!
www.tebu:bio.com!!
www.tegaferm.com!!
www.texbiosciences.com!!
USA!
USA!
www.seydel.com!!
www.thermoscientific.com!!
Japan!
Israel!
Canada!
www.toyobo:global.com!!
www.transbiodiesel.com!!
www.tritex.com!!
Canada!
www.ublcorp.com!!
China!
Japan!
Bulgaria!
USA!
www.unikbio.com!!
www.unitika.co.jp!!
www.vemo:vsv.com!!
www.verenium.com!!
!
x'
x'
'
x'
'
x'
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x'
x'
x'
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x'
x'
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x'
x'
x'
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x'
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'
23!
!
!
!!
Worthington!
Yakult!
Zymetech!
Zytex!
USA!
Japan!
Iceland!
India!
'
x'
Germany!
www.w42biotechnology.de!!
Japan!
www.wako:chem.co.jp!!
Germany!
www.weissbiotech.com!!
www.worthington:
biochem.com!!
www.yakult.co.jp/ypi/en/!!
www.zymetech.com!!
www.zytex.com!!!
x'
'
'
x'
x'
x'
x'
'
'
x'
x'
'
'
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'
'
'
'
'
'
x'
'
'
x'
'
'
'
Distributor!
Primary!
Manufacturer!
www.veskim.com!!
Contract!
Research!
Service!
Turkey!
Contract!
Manufacturer!
Veskim!
W42!Industrial!
Biotechnology!
GmbH!
Wako!Pure!
Chemical!
Industries!
Weiss!Biotech!
GmbH!
Website!
Headquarters!
Company!
x'
'
'
x'
'
'
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'
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'
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'
!
24!
!
!
!!
'
USA!
India!
UK!
Japan!
Italy!
Italy!
Germany!
Netherlands!
Netherlands!
USA!
Italy!
USA!
www.advancedenzymes.com!!
www.bict.it!!
www.chiralvision.com!!
www.cleatechnologies.com!!
www.codexis.com!!
www.cpcbiotech.it!!
www.elementalenzymes.com!!
Germany!
China!
India!
Hungary!
Germany!
Czech!
Republic!
www.fermentia.eu!!
Meito!Sangyo!
Proteogen!Bio!
Prozomix!
Purolite!
Sigma:Aldrich!
SpheriTech!
Sprin!
SynBioCat!Ltd!
Syncozymes!
TransBiodiesel!
W42!Industrial!
Biotechnology!!
Wako!Pure!Chem.!!
Japan!
Italy!
UK!
USA!
USA!
UK!
Italy!
Hungary!
China!
Israel!
www.lentikats.eu!!
www5.mediagalaxy.co.jp/me
ito/kaseihin/index_e.html!!!
www.prozomix.com!!
www.purolite.com!!!
www.spheritech.com!!
www.synbiocat.hu!!
Germany!
Japan!
!
x'
x'
x'
'
x'
x'
x'
x'
x'
x'
x'
'
'
x'
'
x'
x'
x'
'
x'
x'
x'
'
x'
'
x'
x'
x'
x'
x'
x'
'
x'
'
x'
x'
'
x'
x'
'
x'
x'
'
x'
x'
x'
Solid'phases'
for'purchase'
ImmobilizaB
tion'service'
Acore!Pharmatech!
Advanced!Enzyme!
Technologies,!Ltd.!
Almac!Sciences!
Amano!Enzyme!Co!
BiCT!srl!
BioSphere!
CHEMOS!GmbH!
Chiral!Vision!
CLEA!Technologies!
Codexis,!Inc.!
CPC!Biotech!
elementalenzymes!
Emp!Biotech!
GmbH!
EnzymeWorks!
Fermenta!Biotech!!
Fermentia!
Iris!Biotech!GmbH!
Lentikats!
Biotechnologies!
Immobilized'
Enzymes'
Website'
HeadB
quarters'
'Company'
Table'3:'Companies'Offering'Immobilized'enzymes,'Materials,'Services'
'
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'
x'
'
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'
'
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'
x'
'
x'
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x'
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x'
x'
x'
x'
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x'
'
x'
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'
x'
x'
'
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'
25!
!
!
!!
'
'
UK!
www.abvista.com!!
x'
Acore!Pharmatech!
USA!
Actygea!
Italy!
www.actygea.com!!
Addiseo!
France!
www.adisseo.com!!
Advanced!Enzyme!
Technologies,!Ltd.!
India!
www.advancedenzymes.com!!
Agrimex!
Belgium!
www.agrimex.be!!
Ajinomoto!
Japan!
www.ajinomoto.com!!
'
x'
Aldevron!
USA!
www.aldevron.com!!
x'
Alea!Evolution!
Italy!
www.alea:evolution.com!!
Alfa!Kimya!Company!
Turkey!
www.en.alfakimya.com!!!
AlfaNzyme!Bio:Tech!
India!
'
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x'
x'
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x'
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x'
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x'
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x'
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'
x'
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x'
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'
'
Alliance!Enzyme!Pvt!Ltd! India!
Alltech!USA!
USA!
www.alltech.com!!
'
x'
Almac!Sciences!
UK!
x'
Alpha!Diagnostic!
International!
USA!
www.4adi.com!!
!
Australia!
AB!Vista!
Africa!
x'
South!America!
www.abenzymes.com!!
Asia!
Germany!
Europe!
AB!Enzymes!
North!America!
Global!
Website!
Company!
Headquarters!
Table'4:'Companies'Listed'by'Geographical'Location'or'Sales'Regions'
x'
x'
26!
!
!
!!
'
American!Laboratories,!
Inc!
USA!
www.americanlaboratories.c
om!!
'
Americos!Industries!Inc! India!
www.kenencoregroup.com!!
Amit!Biotech!Pvt.!Ltd.!
India!
AMPLICON!
Czech!
Republic!
www.amplicon.cz!!
Ampliqon!A/S!
Denmark!
www.ampliqon.com!!
ANC!Enzymes!
Singapore!
www.ancenzymes.com!!
'
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x'
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'
x'
x'
'
'
'
'
x'
www.pintaluba.com!!
'
x'
Anil!Bioplus!
India!
www.anilbioplus.com!!
x'
Anthem!Cellutions!
India!
www.anthemcell.com!!
Apollo!Chemical!
Company!
USA!
www.apollochemical.com!!
'
Apollo!Scientific!
UK!
www.apolloscientific.co.uk!!
x'
Applied!Biotechnology!
Institute!
USA!
www.appliedbiotech.org!!
'
Archaenzyme!Ltd!
Israel!
www.archaezyme.com!!
ArcticZymes!
Norway!
www.arcticzymes.com!!!
'
x'
Germany!
www.genecraft.de!!
x'
!
'
'
Andrés!Pintaluba,!S.A.!!!!! Spain!
Ares!Bioscience!GmbH!
Australia!
USA!
Africa!
American!Biosystems!
www.americanbiosystems.co
m!!
South!America!
x'
Asia!
Europe!
Amano!Enzyme!Co.!Ltd.! Japan!
North!America!
Global!
Website!
Company!
Headquarters!
'
'
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x'
x'
x'
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x'
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27!
!
!
!!
Australia!
'
Africa!
Europe!
'
South!America!
North!America!
'
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'
x'
'
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'
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'
'
Asia!
Global!
Website!
Company!
Headquarters!
(Genecraft)!
Arun!and!Co!
India!
www.arunandco.com!!
ASA!Spezialenzyme!
GmbH!
Germany!
www.asa:enzyme.de!!
'
Asahi!Kasei!Pharma!
Japan!
www.asahi:kasei.com!!
x'
AUMEnzymes!
India!
Aumgene!
India!
www.aumgene.com!!
BASF!!
Germany!
www.basf.com!!
'
x'
BBI!Enzymes!
UK!
www.bbienzymes.com!!
x'
BehnMeyer!
Germany!
www.behnmeyer.com!!
x'
Beldem!
Belgium!
www.beldem.com!!
x'
Berg!+!Schmidt!GmbH!&!
Co.!KG!
Germany!
Bergerow!
Germany!
www.begerow.com!!
Berlin!Chemical!
China!
BiCT!srl!
Italy!
www.bict.it!!
BIO:CAT!
USA!
www.bio:cat.com!!
Biocat!Collection!
Germany!
www.biocatcollection.net!!
Biocatalysts!Ltd.!
UK!
www.biocatalysts.com!!!
Biochem!
Germany!
www.biochem.net!!
!
'
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x'
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x'
x'
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x'
'
x'
'
x'
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x'
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x'
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x'
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x'
x'
'
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x'
'
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'
'
28!
!
!
!!
'
BioPox!
Italy!
www.biopox.com!!
Biorbyt!Ltd.!!
UK!
www.biorbyt.com!!
BioResearch!Products!
USA!
www.bio:researchprod.com!!
Bioron!GmbH!
Germany!
www.bioron.net!!
Bioseutica!
Netherlands! www.bioseutica.com!!
x'
BioSphere!
Italy!
x'
biovet!
Bulgaria!
www.biovet.com!!
x'
Biozym!
Germany!
www.biozym.com!!!!
BioZyme!
Romania!
www.biozyme.ro!!!
BRAIN!AG!
Germany!
Brenntag!
'
x'
'
x'
Australia!
www.bio:port.cz!!!
Africa!
Czech!
BIO:PORT!Europe!s.r.o.! Republic!
South!America!
x'
Asia!
Global!
www.biomin.net!!
Europe!
Austria!
North!America!
Biomin!
Website!
Company!
Headquarters!
'
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x'
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'
www.brain:biotech.de!!
'
x'
Germany!
www.brenntag.com!!
x'
BSC!Biochemicals!
Belgium!
www.bscbio.be!!
C.Schliessmann!
Germany!
www.c:schliessmann.de!!
C5.6!Technologies!
USA!
www.c56technologies.com!!!
Calzyme!
USA!
www.calzyme.com!!
'
x'
Cambrex!IEP!GmbH!
USA!
www.cambrex.com!!
x'
Cellectis!SA!
France!
www.cellectis.com!!
x'
!
'
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x'
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x'
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x'
x'
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x'
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x'
x'
29!
!
!
!!
www.chematics.com!!
CHEMOS!GmbH!
Germany!
Chimab!
Italy!
www.chimab.it!!
Chiral!Vision!
Netherlands! www.chiralvision.com!!
'
x'
Chr.!Hansen!
Denmark!
www.chr:hansen.com!!
x'
CHT/BEZEMA!
Germany!
www.cht:group.com!!
x'
CLEA!Technologies!
Netherlands! www.cleatechnologies.com!!
x'
c:LEcta!GmbH!
Germany!
www.c:lecta.com!!
x'
Codexis,!Inc.!
USA!
www.codexis.com!!
x'
Colotex!Company!Ltd!
Hong!Kong! www.colotexbiotech.com!!
Concord!Biotech!
India!
www.concordbiotech.com!!
'
x'
Condor!Specialty!
Products!
USA!
www.condorspecialty.com!!
'
CPC!Biotech!
Italy!
www.cpcbiotech.it!!
x'
Creative!BioMart!
USA!
x'
Deltagen!Bioproducts!
N.A.!
Netherlands!
Antilles!
www.deltagenbiop.com!!!
Direvo!Industrial!
Biotechnology!GmbH!
Germany!
www.direvo.com!!
Discovery!Biocatalysts!
UK!
www.discovery:bc.co.uk!!
'
'
'
x'
x'
'
x'
'
'
Australia!
USA!
Africa!
Chematics!
!
x'
South!America!
www.centerchem.com!!
Asia!
USA!
Europe!
Centerchem!
North!America!
Global!
Website!
Company!
Headquarters!
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30!
!
!
!!
Dong!Nam!Chemicals!&!
Equipments!Corporation! Vietnam!
DSM!
Netherlands! www.dsm.com!!
DuPont!(Danisco:
Genencor)!
USA!
www.dupont.com!!
Dyadic!
USA!
www.dyadic.com!!!
x'
DyStar!
Germany!
www.dystar.com!!
x'
Elanco!(Chem!Gen)!
USA!
www.elanco.us!!
x'
elementalenzymes!
USA!
EMELCA!Bioscience!
Belgium!
www.emelcabio.com!!!!
Emp!Biotech!GmbH!
Germany!
Enantis!
Czech!
Republic!
www.enantis.com!!
'
Enartis!Vinquiry!
Italy!
www.enartis.com!!
x'
Engrain!
USA!
www.engrain.us!!
ENGroup!
China!
www.engroup.cn!!
EnMex!SA!DE!CV!
Mexico!
www.enzymes.com.mx!!
Enzagen!
UK!
www.enzagen.com!
'
'
Enzybel!International!
Belgium!
www.enzybel.com!!
x'
!
x'
x'
'
'
'
'
'
Australia!
'
Africa!
www.dongnamlab.com!!
x'
South!America!
'
North!America!
Global!
www.klentaq.com!!
Asia!
USA!
Europe!
DNA!Polymerase!
Technology!Inc.!
Website!
Company!
Headquarters!
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31!
!
!
!!
www.enzymatics.com!!
USA!
www.EnzymeDevelopment.c
om!!
'
Australia!
www.enzymesolutions.com.a
u!!
'
Enzyme!Development!
Corporation!
Enzyme!Solutions!
'
Enzyme!Solutions!(USA)! USA!
Enzyme!Supplies!
UK!
www.enzymesupplies.com!!
EnzymeKing!
Biotechnology!Co.!Ltd!
China!
Enzymes!Naveen!
India!
!!
EnzymeWorks!
China!
Enzymicals!AG!
Germany!
Enzymology!Research!
Center!Inc!
USA!
www.ercenzymes.com!!
Enzyvia!LLC!
USA!
www.enzyvia.com!!
epicentre!
USA!
www.epibio.com!!
'
x'
epygen!
UAE!
www.epygen.com!!
x'
ERA!Biotech!
Spain!
www.erabiotech.com!!
Erbsloh!Geisenheim!AG! Germany!
Eucodis!Biosciences!
Austria!
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www.erbsloeh.com!!
'
x'
www.eucodis.com!!
x'
!
Australia!
USA!
Africa!
Enzymatics!
'
South!America!
www.edt:enzymes.com!!
Asia!
USA!
Europe!
Enzymatic!Deinking!
Technologies,!LLC!
North!America!
Global!
Website!
Company!
Headquarters!
x'
x'
'
'
x'
x'
x'
x'
x'
32!
!
!
!!
North!America!
Europe!
Asia!
South!America!
Africa!
Australia!
Global!
Website!
Headquarters!
Company!
'
'
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'
GmbH!
Evocatal!GmbH!
Germany!
www.evocatal.com!!
x'
Fenkin!Kimya!Sanayi!Ve!
Ticaret!Ltd!
Turkey!
www.fenkim.com!!
'
Fermenta!Biotech!Ltd!
India!
x'
Fermentia!
Hungary!
www.fermentia.eu!!
Fytozimus!
Canada!
www.fytozimus.com!!
Galilaeus!Oy!
Finland!
www.galilaeus.fi!!
Genkim!
Turkey!
www.genkim.com.tr!!
GenScript!USA!Inc!
USA!
www.genscript.com!!
'
x'
GNCBioferm!
Canada!
www.gncbioferm.ca!!
x'
Habio!Bioengineering!
China!
www.habio.net!!
x'
Huvepharma!
Bulgaria!
x'
IBEX!
Canada!
www.ibex.ca!!
x'
Imperial!Jade!Bio:
Technology!Co.,!Ltd.!
China!
www.imperialjade12.en.chin
a.cn!!!
'
Infinite!Enymzes!
USA!
www.infiniteenzymes.com!!!
InnoTech!MSU!
Russia!
www.innotech:msu.com!!
Iris!Biotech!GmbH!
Germany!
Jena!Bioscience!GmbH! Germany!
www.jenabioscience.com!!
!
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33!
!
!
!!
Africa!
Australia!
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Jiangsu!Boli!Bioproducts!
Co.!Ltd!
China!
www.bolibio.com!!
'
'
'
Jiangsu!OGO!Biotech!
Co.,!Ltd.!
'
'
'
Jinan!Tiantianxiang!Co.,!
Ltd.!
China!
www.jnttx.com!!
'
'
'
Johnson!Matthey!
UK!
www.jmcct.com!!
x'
'
Kemikalia!
Sweden!
www.kemikalia.se!!
Kemin!
USA!
www.kemin.com!!
'
x'
'
x'
'
Kerry!Americas!
USA!
www.kerry.com!!
x'
Kiotechagil!
UK!
x'
Kiwienzyme.com!Ltd!
New!
Zealand!
'
Lactosan!GmbH!
Austria!
www.lactosan.at!!
x'
Laffort!
France!
www.laffort.com!!
x'
Lallemand!
Canada!
www.lallemand.com!!
x'
Lamothe:Abiet!
France!
www.lamothe:abiet.com!!
x'
Lanxess!
Germany!
www.lanxess.com!!!!!
x'
Larbus!s.a.!
Spain!
www.larbus.com!!
Lentikats!
Biotechnologies!
Czech!
Republic!
www.lentikats.eu!!
Leveking!Enzymes!
China!
www.levekingenzymes.com!!
China!
!
'
x'
x'
'
'
Asia!
'
Europe!
South!America!
North!America!
Global!
Website!
Company!
Headquarters!
x'
x'
x'
x'
34!
!
!
!!
USA!
www.lifetechnologies.com!!
Lonza!
Switzerland! www.lonza.com!!
x'
Lucigen!
USA!
lucigen.com!!
x'
Lumis!Biotech!
Inda!
www.lumisbiotech.com!!
Lybradyn!
USA!
www.lybradyn.com!!
Lyven!
France!
www.lyven.com!!
x'
'
'
Australia!
Life!Technologies!
(GeneArt)!
Africa!
x'
South!America!
www.libragen.com!!
Asia!
France!
Europe!
Libragen!
North!America!
Global!
Website!
Company!
Headquarters!
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www.mlindia.com!!
'
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India!
www.mapsenzymes.com!!
x'
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Megazyme!Ireland!
Ireland!
www.megazyme.com!!
x'
'
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Meito!Sangyo!
Japan!
www5.mediagalaxy.co.jp/mei
x'
to/kaseihin/index_e.html!!
'
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'
Menlo!
Biotech/Ecozymes!
UK!
www.menlobiotech.com!!!
'
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M!L!CHEMICALS!(INDIA)!
PVT!LTD.!
India!
Maps!Enzyme!Limited!
'
Merck!KGaA!(EMD!
Millipore,!Calbiochem)! Germany!
www.emdgroup.com!!
Metabomics!
China!
www.metabomics.com!!
Metgen!Oy!
Finland!
www.metgen.fi!!
'
x'
Millbo!
Italy!
www.millbo.com!!
x'
Mirpain!
Turkey!
www.mirpain.com!!
x'
!
x'
x'
x'
x'
'
35!
!
!
!!
Europe!
Asia!
South!America!
Africa!
Australia!
'
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Germany!
x'
MP!Biomedical!
USA!
www.mpbio.com!!
x'
Nagase!
Japan!
www.nagasechemtex.co.jp!!
Najing!Chemlin!Chemical!
Industry!
China!
www.chemlin.guidechem.co
m!!!
NEB!
USA!
www.neb.com!!
x'
Nordmann,!Rassmann!
Germany!
www.nordmann:
rassmann.com!!
x'
Novozymes!
Denmark!
www.novozymes.com!!
x'
Novus!
USA!
www.novusint.com!!
x'
Nutreco!
Netherlands! www.nutreco.com!!!!
x'
Nzomics!Biocatalysis!
UK!
www.nzomics.com!!
NZYTech!
Portugal!
www.nzytech.com!!
OenoBioTech!SAS!
France!
www.oenobiotech.com!!
Oenobrands!
France!
OptiGene!
Global!
Mühlenchemie!
Company!
Website!
'
Headquarters!
North!America!
'
x'
'
'
www.oenobrands.com!!
'
x'
UK!
x'
ORBA!
Turkey!
www.orba.com.tr!!
Oriental!Yeast!
Japan!
www.oyc.co.jp!!
Parchem!
USA!
www.parchem.com!!
Prochimica!Group!
Italy!
www.prochimicagroup.com!!
!
'
x'
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36!
!
!
!!
Australia!
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www.papain.in!!
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Sartoris!Stedim!Biotech! France!
x'
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Scott!Laboratories!
USA!
www.scottlab.com!!
'
x'
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Season!Chemicals!
Dyestuffs!
Hong!Kong! www.sesaonchemicals.com!!
'
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Sekisui!Enzymes!
UK!
x'
'
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'
Global!
Columbia!
www.proenzimas.com!!
Promega!
USA!
www.promega.com!!
Protean!
Czech!
Republic!
http://www.protean.cz
Proteogen!Bio!
Italy!
Prozomix!
UK!
www.prozomix.com!!
Prozyme!
USA!
www.prozyme.com!!
Purolite!
USA!
www.purolite.com!!!
'
x'
Research!Products!
Company!
USA!
www.researchprod.com!!!
'
Roal!Oy!
Finland!
www.roal.fi!!
RobinsonBioproducts!
Canada!
www.robinsonbioproducts.co
m!!
Roche!
Switzerland! www.roche.com!!
Rossari!Biotech!
India!
www.rossari.com!!
S!I!CHEMICAL!
INDUSTRIES!
India!
!
www.sekisuienzymes.com!!
!
'
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Asia!
'
Proenzimas!Ltda!
Europe!
'
Website!
Africa!
South!America!
North!America!
Company!
Headquarters!
'
x'
'
x'
'
x'
x'
x'
x'
x'
x'
x'
'
x'
37!
!
!
!!
China!
North!America!
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Europe!
Australia!
Shandong!Longda!Bio:
Products!Co.,!Ltd.!
Africa!
www.senson.fi!!
South!America!
Finland!
Asia!
Senson!Ltd!
Global!
Website!
Company!
Headquarters!
x'
'
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'
SHIN!NIHON!CHEMICAL!
CO.,!LTD.!
Japan!
www.aichi:
brand.jp/corporate/type/che
mical/shin:nihon:e.html!!
x'
'
'
SibEnzyme!
Russia!
www.sibenzyme.com!!
x'
'
Sigma:Aldrich!
USA!
x'
SinoBios!!
China!
www.sinobios.com!!
Specialty!Enzymes!and!
Biotechnologies!Inc.!
USA!
www.specialtyenzymes.com!!
SpheriTech!Ltd.!
UK!
www.spheritech.com!!!
Sprin!
Italy!
SternEnzym!
Germany!
www.sternenzym.de!!
Strem!
USA!
www.strem.com!!
Sukahan!
China!
www.sukahan.com!!
Sunson!Industry!Group!
Company!Limited!
China!
www.chinaenzymes.com!!
SynBioCat!Ltd!
Hungary!
www.synbiocat.hu!!
Syncozymes!
China!
Takabio!
France!
www.takabio.com!!
tebu:bio!
France!
www.tebu:bio.com!!
!
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38!
!
!
!!
Tex!Biosciences!
India!
www.texbiosciences.com!!
North!America!
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'
ThermoFisher!
USA!
www.thermoscientific.com!!
'
x'
Toyobo!Enzymes!
Japan!
www.toyobo:global.com!!
x'
TransBiodiesel!
Israel!
Tri:Tex!Co!
Canada!
www.tritex.com!!
Ultra!Bio:Logics!Inc.!
Canada!
www.ublcorp.com!!
'
x'
Unikbio!
Biotech(Guangzhou)!Ltd! China!
www.unikbio.com!!
'
Unitaka!
Japan!
www.unitika.co.jp!!
x'
VEMO!99!Ltd!!
Bulgaria!
www.vemo:vsv.com!!
Verenium!
USA!
www.verenium.com!!
Veskim!
Turkey!!
www.veskim.com!!
W42!Industrial!
Biotechnology!GmbH!
Germany!
Wako!Pure!Chemical!
Industries!
Japan!
Weiss!Biotech!GmbH!
Germany!
www.weissbiotech.com!!
USA!
www.worthington:
biochem.com!!
'
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'
Asia!
'
Europe!
'
'
www.seydel.com!!
!
'
x'
x'
'
The!Seydel!Companies! USA!
Worthington!
Australia!
www.tegaferm.com!!
Africa!
Austria!
South!America!
Tegaferm!
Global!
Website!
Headquarters!
Company!
x'
39!
!
!
!!
Iceland!
www.zymetech.com!!
x'
Zytex!
India!
www.zytex.com!!
x'
''
Australia!
Zymetech!
Africa!
x'
South!America!
www.yakult.co.jp/ypi/en/!!
Asia!
Japan!
Europe!
Yakult!
North!America!
Global!
Website!
Headquarters!
Company!
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!
40!
!
!
!!
AB'Enzymes'GmbH'
http://www.abenzymes.com/!!
Feldbergstrasse!78!
64293!Darmstadt!
Germany!
Tel:!+49!(0)!61!51:36!80:100!|!Fax:!+49!(0)!61!51:36!80:120!
Email:[email protected]!
Year!Founded!
Size!($!or!employee!
count!or!both)!
Company!type!
Enzyme!sales!absolute!
and/or!as!a!percentage!
of!company!sales!
Enzyme!markets!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1907!
201:500!employees!
Subsidiary!of!public!company:!Associated!British!Foods!plc,!ticker!ABF!
Enzymes!sales!are!grouped!together!with!other!ingredients,!and!the!total!for!
all!such!sales!in!2012!was!about!£1!billion,!or!$1.6!billion.!
Textiles,!paper!and!pulp,!detergents,!baking,!food,!animal!feed,!biofuels,!
brewing,!and!winemaking.!
Trichoderma,,Aspergillus,,Bacillus,,and,other,standard,hosts!
Multi:ton.!!In:house!production!
Aryan!Moelker,!CEO;!Karl:Heinz!Maurer,!Director!of!Business!Development!
Distributes!in!part!through!Barentz,!partnered!with!Genedata!for!strain!
engineering,!distributes!enzymes!for!Finnish!enzyme!company!Roal!Oy.!!Roal!
Oy!is!a!joint!venture!of!Associated!British!Foods!plc!and!Altia.!
Extensive,!global!
+++!(profitable!company!generating!dividends!for!shareholders)!
+++!!
:!
AB!Enzymes!is!a!subsidiary!of!ABF!Ingredients,!which!is!in!turn!a!subsidiary!of!Associated!British!Foods!
plc,!and!has!its!origins!in!1907!when!Röhm!and!Haas!was!founded.!!The!company!sells!industrial!
enzymes!worldwide!and!has!offices!in!several!countries.!!The!company!engineers!both!enzymes!and!
production!strains,!and!has!manufacturing!plants!in!multiple!countries.!
Products:!
Amylases!
Xylanases!
Transglutaminases!
!
41!
!
!
!!
Proteases!
Lipases!
Cellulases!
Pectinases!
Arabinases!
Beta:glucanases!
Papain!
Phytase!
Phospholipase!
Mannanase!
Catalase!
!
!
!
'
'
!
42!
!
!
!!
A.B.'Vista'
www.abvista.com!!
Woodstock!Court!
Blenheim!Road!
Marlborough!Business!Park!
Marlborough!
Wiltshire!
SN8!4AN!
UK!
Tel:!+44(0)1672!517!650!
[email protected]!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
51:200!employees!
Part!of!Associated!British!Foods!
Significant!portion!
Animal!feed.!
Trichoderma,,Aspergillus,,Bacillus,,and!other!standard!hosts!via!AB!Enzymes,,
Bulk.!!Done!in:house!by!parent!company!AB!Enzymes.!
Richard!Cooper,!Managing!Director!
AB!Vista!is!the!distributor!of!feed!enzymes!for!AB!Enzymes!GmbH,!the!sole!
distributor!of!Roal!Oy.!Both!AB!Vista!and!AB!Enzymes!are!part!of!the!
Associated!British!Food!plc!(ABF)!group.!Roal!has!the!brand!expertise,!R&D!
expertise!and!production!technology!to!produce!a!range!of!enzyme!products!
for!the!feed!industry.!AB!Vista!provides!supplementary!marketing!and!
technical!support!for!the!feed!market,!along!with!the!sales,!logistics!and!
customer!service!support!to!optimise!its!feed!enzyme!offering.!
Global!
+++!
+!
:!
AB!Vista!is!focused!on!animal!nutrition!enzymes.!
Products:!Phytases,!Xylanases'
!
!
43!
!
!
!!
Acore'Pharmatech!
29!Tennyson!Dr.!
Plainsboro,NJ!08536!
USA!
Tel:!+1:609:755:4073!
Fax:!+1:609:755:0590!
Email:[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!(as!Syncore!Labs,!now!Syncozymes)!
About!$5:10!million!annually!(Syncozymes),!11:50!employees!
Private!
The!company!offers!both!enzymes!and!chemical!intermediates.!
Biocatalysis,!diagnostics.!
NA;!see!Syncozymes!
Syncozymes’!fermentation!capabilities!include!fermenters!of!greater!than!
100!L!capacity,!and!the!company!offers!enzyme/chiral!products!on!a!100!kg!
scale!with!a!3:4!month!lead!time.!!!
James!Wen!is!listed!as!Founder!and!CEO!in!his!LinkedIn!profile!
Acore!is!the!US!division!of!the!Chinese!company!Syncozymes!
Pharmaceutical!and!chemical!companies!for!biocatalysis!applications!
+!(a!CRO/CMO,!which!has!experienced!uneven!revenues!year!to!year)!
+++!(extensive)!
+!(small!scale)!
Acore!is!the!US!business!office!and!distributor!for!Syncozymes.!!Syncozymes!in!turn!is!the!current!name!
for!the!company!founded!in!2008!as!Syncore!Labs!in!Shanghai!China.!!Acore!distributes!enzymes!and!
chemical!intermeidates!developed!in!and!shipped!from!Syncozymes.!!Therefore,!all!data!above!are!
indicative!of!Syncozymes,!the!parent!company.!!For!more!information,!see!the!entry!for!Syncozymes.!!
Products:!
The!catalog!from!SYncozymes!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!the!
following!in!both!individual!enzyme!and!enzyme!kit!format:!!
Ene!reductases!!
!
44!
!
!
!!
Ketoreductases!
Transaminases!
Lipases!
Proteases!
Amidases!
Nitrilases!
Nitro!reductases!
Alcohol!oxidases!
Glycosidases!
Nitrile!hydratases!
Cytochrome!P450s!
Aldolases!
Cofactor!regeneration!enzymes!
Amino!acid!dehydrogenases!
Glucose!dehydrogenase!
Glucose:6:phosphate!dehydrogenase!
3a:hydroxysteroid!dehydrogenase!
Bilirubin!oxidase!
Uricase!
Ascorbate!oxidase!
Peroxidase!
Xanthine!oxidase!
Glutamate!dehydrogenase!
Glycerol!kinase!
Pyruvate!kinase!
!
45!
!
!
!!
Urease!
Adenosine!deaminase!
!
!
46!
!
!
!!
Actygea'
http://www.actygea.com/!!
Insubrias!BioPark!
via!R.!Lepetit!34!
21040!Gerenzano!(VA)!!
Italy!
Tel:!!+39!02!96474!1!
Fax:!+39!02!96474!500!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
Very!small!
Private!
None!
NA!
Proprietary!strains,!bacteria,!fungi!
One!2000!L!fermenter,!two!200!L!fermenters,!one!!50!L!fermenter,!one!30!L!
fermenter!and!many!other!smaller!vessels!
Fabrizio!Beltrametti,!CEO!and!Co:Founder!
NA!
NA!
NA!
:!
+!
Actygea!S.r.l.,!specializes!in!novel!organisms,!strains,!and!contract!fermentation,!as!well!as!downstream!
processing!and!purification!of!those!products.!!The!company!seeks!to!produce!enzymes!and!other!
products!on!a!contract!basis.!!Actygea!is!taking!part!in!a!European!grant!called!MetaExplore!to!identify!
novel!enzymes.!
!
!
'
'
!
47!
!
!
!!
Adisseo'
http://www.adisseo.com/!!
Immeuble!Antony!Parc!2!
10,!Place!du!Général!de!Gaulle!
92160!Antony!
France!
Tel:!+33!(0)1!46!74!70!00!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
1700!employees!including!parent!
Adisseo!Group!is!one!of!the!main!subsidiaries!of!China!National!BlueStar,!a!
key!player!in!the!chemical!industry!in!China!with!30,478!staff!and!a!turnover!
of!6.9!billion!euros.!
Animal!feed!!
A!non:genetically!modified!strain!of!Penicillium,funiculosu,!and!
Schizosaccharomyces,pombe!
Bulk.!!In:house!production!likely.!
NA!
NA!
Global.!
+++!
++!
:!
Adisseo!is!an!animal!nutrition!company.!
Products:!
Xylanases!
Phytases!
Beta:glucanases!
'
'
!
48!
!
!
!!
Advanced'Enzyme'Technologies'Ltd.'
http://www.advancedenzymes.com/!!
Corporate!Office!
5th!Floor,!'A'!wing,!Sun!Magnetica!
LIC!Service!Road,!Louiswadi!
Thane!(W)!400!604!
India!
Tel:!+91:22:4170!3200!
Fax:!+!91:22:25835159!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1959!
33!million!USD!in!2012,!201:500!employees.!
Expected!to!go!public!soon!
100%!of!sales!from!enzymes!and!formulated!enzyme!–based!products.!
Biocatalysis,!leather,!textiles,!pharmaceutical,!animal!feed,!food,!paper,!
biofuels.!
Mostly!natural!hosts!in!plants,!bacteria,!animals,!and!fungi!
More!than!500!MT!per!month!in!enzyme!concentrate,!four!total!plants.!!In:
house!production.!
Run!by!Chandrakant!L.!Rathi,!CEO!and!Vasant!L.!Rathi,!Chairman!
Specialty!Enzymes!and!Biotechnologies!in!the!US!is!a!subsidiary!
More!than!700!customers!across!45!countries!worldwide!
+++!(profitable,!dividend!payer)!
+++!(55+!enzymes,!extensive!offerings)!
:!
Advanced!Enzymes!is!a!large!and!growing!enzyme!manufacturing!company!with!a!long!history!in!India.!!
The!first!product!was!papain,!extracted!from!locally:grown!papayas.!Now!Advanced!Enzymes!operate!4!
manufacturing!plants,!with!offices!in!countries!around!the!world,!and!a!major!subsidiary!in!the!USA!
(Specialty!Enzymes!and!Biotechnologies).!!The!company!filed!for!an!IPO!in!India!in!2013,!and!expects!to!
raise!money!to!expand!manufacturing!capacity.!!Advanced!Enzymes!is!the!second!largest!enzyme!seller!
in!India!behind!Novozymes,!and!the!company!sells!53%!of!their!products!in!Europe!and!the!United!
States.!!
!
49!
!
!
!!
Products:!
Serropeptidase!
Lipases:!CAL:B!(soluble!and!immobilized);!Aspergillus!niger;!Lipase!TL!(Thermomyces!lanuginosus);!
Rhizopus!delemar;!Candida!rugosa!
Proteases:!papain;!bromelain;!!
Peptidases:!Serrariopeptidase;!Endo!Proline!Peptidase;!Leuicine!Amino!Peptidase!Exo;!Exo!Proline!
Peptidase!
!
Ferulic!acid!esterase!
!
Lactase!
!
Nattokinase!
Alpha:galactosidase!
Beta:glucosidase!
Beta:xylosidase!
Beta:mannosidase!(Mannanase)!
Cellulase!
Hemicellulase!(xylanase)!
Amylases!(Alpha:amylase,!glucoamylase)!
Beta:glucanases!
Xylo:oligosidase!
Manno:oligosidase!
Pectinase!
Phytase!
Phospholipase!
Glucose!oxidase!
Tannase!
Catalase!
!
50!
!
!
!!
Agrimex'NV'
http://www.agrimex.be/!!
Achterstenhoek!5!
2275!Lille!
Belgium!
Tel:!+32!14!88!22!11!
Fax:!+32!14!88!33!40!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
11:50!
Private,!owned!by!the!Kuge!Invest!Group,!a!Belgian!holding!company.!
Small!
Animal!feed!
NA!
Bulk.!!No!in:house!production.!
NA!
Distributes!for!Beldem.!
NA!
NA!
+!
:!
From!the!website:!“Agrimex!is!specialized!in!the!development,!production!and!marketing!of!specialty!
products!for!the!feed!industry.!Besides!sales!and!marketing!of!its!own!products!throughout!Europe,!
Agrimex!is!the!exclusive!distributor!in!the!Benelux!market!for!a!number!of!reputable!manufacturers!of!
high!quality!feed!ingredients!and!raw!materials.”!
Products:!
Xylanase!
!
'
'
!
51!
!
!
!!
Ajinomoto'
www.ajinomoto.com/en/!!
15:1,!Kyobashi!1:chome!
Chuo:ku,!Tokyo!104:8315!
Japan!
Tel:!+81!3!5250!8111!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1909!
27,000!employees!
Public!
Less!than!1%!
Food!ingredients,!meat!tenderizing.!
NA!
Bulk.!!In:house!production,!particularly!for!amino!acids!for!animal!feed!and!
food!
Masatoshi!Ito,!CEO!
Torray!for!biobased!nylon;!OmniChem!subsidiary!for!manufacture!of!
pharmaceutical!fine!chemicals!
Global!
+++!
+!
:!
From!the!website:!“Ajinomoto!Co.,!Inc.!is!the!Tokyo:based!food,!beverage,!and!amino!acid!powerhouse!
that!is!one!of!East!Asia’s!best:known!and!most!respected!brands,!with!annual!sales!of!US$10!billion!
worldwide.!Manufacturing!and!marketing!a!diverse!range!of!products!around!the!globe,!Ajinomoto!is!a!
leading!producer!of!amino:acid!based!specialty!chemicals!:!humectants,!surfactants,!emollients,!and!
functional!powders!for!the!cosmetics!and!toiletries!industries.”!
Products:!
Transglutaminase!(Brand!name!Activa®)!
!
!
'
'
!
52!
!
!
!!
Aldevron'
www.aldevron.com!!
3233!15!Street!South!!
Fargo,!ND!58104!!
USA!
Tel:!+1:701:297:9256!
Tel:!+1+877:PURE:DNA!(787:3362)!
Fax:!+1:701:280:1642!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1998!
51:200!employees!
Private!
None!
NA!
E.,coli,!Insect,!Mammalian!
Scale!—!1!ml!to!240!L.!!In:house!production.!
Michael!Chambers,!CEO!and!Co:Founder!
NA!
USA,!Germany!
++!(growing)!
:!
+!
Aldevron!produces!DNA,!proteins,!and!antibodies!on!a!contract!research!and!development!and!contract!
manufacturing!organization.!!!
!
!
!
'
'
!
53!
!
!
!!
Alea'Evolution'
http://www.alea:evolution.com/!!
Via!S.!Pertini!n.!12!
40062!Molinella!(BO)!
Italy!
Tel:!+39!335!7668356!
Fax:!+39!051!0544133!
Email:!info@alea:evolution.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Enzymes!are!about!25%!of!the!company’s!offerings,!which!include!tannins!
and!other!additives,!yeasts,!and!bacteria.!
Winemaking!!
NA!
GIanpaolo!Guinelli,!Sales!manager;!Enrico!Bortolini,!Technical!Manager;!
Stefano!Guinelli,!Director!and!Technical!Manager!
Verenium!supplies!the!enzymes!that!the!company!sells.!Partners!include!
Lallemand!and!various!wine!companies!
Lallemand,!DIversey,!Win!&!Tech!Pura,!Enotrading,!Exacta!Optech,!Enopoint!
NA!
+!(small!assortment)!
:!
Alea!Evolution!primarily!supplies!materials!to!the!wine!industry!in!Italy.!
Products:!
Pectinases!
Lysozyme!
Hemicelluase!
Beta:glucosidase!
'
'
!
54!
!
!
!!
Alfa'Kimya'
http://en.alfakimya.com/!!!
Merkez!Mah.!Dereboyu!Cad.!No:55!
34303!Halkalı,!Istanbul!
Turkey!
Tel:!+90!(212)!548!88!28!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Fax:!+90!(212)!548!88!27!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Email:[email protected]!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1983!
NA!
NA!
Small!
Textiles!
NA!
NA!
BASF,!Akkim,!Novozymes,!Zschimmer&Schwarz!Mohsdorf!
NA!
NA!
++!(selection!of!about!a!dozen!enzymes)!
:!
Alfa!Kimya!is!a!distributer!for!enzymes!from!Novozymes!and!BASF!in!Turkey.!!!
Products:!
Amylase!
Pectinase!
Catalase!
Cellulase!
Protease!(Savinase)!
Laccase!!
!
55!
!
!
!!
AlfaNzyme'BioBTech'
Plot!No.!72,!Kanbargi!Layout,!Ramteertha!Nagar!
Belgaum!590016!Karnataka!
India!
Tel:!+91:831:3194000/6535248!
Fax:!+91:831:2454688!
Email:[email protected];[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
Below!US$1!Million!
Private!
Major!source!of!revenues!
Pulp!and!paper,!baking,!animal!feed,!grain!processing,!alcohol!fermentation,!
textiles!
NA!
Bulk.!!In:house!manufacture!not!specified.!
Mr.!Manas!Ranjan!Samal!
NA!
NA!
NA!
+!
:!
AlfaNzyme!Bio:Tech!sells!a!variety!of!agricultural!and!industrial!chemicals!and!bioproducts,!including!
enzymes.!
Products:!
Non:specified!enzymes!for!the!enzyme!categories!above,!including:!!
Proteases!
Carbohydrate!hydrolases!
Amylases!
Phytase!
!
56!
!
!
!!
Alliance'Enzyme'Pvt'Ltd!
2027:2028,!Jash!Market,!Ring!Road!
Surat!:!395002,!Gujarat!
India!
Tel:!+1:91:261:2339493/2363774/3073388!
Fax:!+1:91:261:2334135!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Nearly!all!revenues!are!enzyme!sales!
Food!and!human!health!applications!
Extraction!from!plant!tissue!
Bulk.!!In:house!production.!
Chandresh!Vasani,!Director!
NA!
NA!
NA!
+!
:!
From!the!website:!“We!are!a!manufacturer,!supplier,!exporter,!importer,!and!trader!of!Pharmaceuticals!
Enzyme!such!as!Refined!Papain!Powder!and!Ultra!Refined!Papain!Powder.!We!also!proivde!Food!Enzyme!
like!Liquid!Papain!and!Industrial!Enzyme!such!as!Crude!Papain,!USP!Papain!and!IP!Papain.!We!offer!these!
products!in!various!grades!and!specifications!as!per!the!needs!of!the!clients.”!
Products:!
Papain!
Bromelain!
!
!
!
!
!
57!
!
!
!!
Alltech'
http://www.alltech.com/!!
3032!Catnip!Hill!Pike!Nicholasville!!
Lexington!KY!40356!!
USA!
Tel:!+1:859:885:9613!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1980!
1001:5000!employees!
Private!
Small!
Animal!feed!enzyme.!!It!calls!its!enzyme!product!Allzyme,!which!is!a!mixture!
of!carbohydrate:degrading!enzymes!and!phytase.!
Naturally!selected!(non:genetically!modified)!strain!of!Aspergillus,niger.!
Bulk.!!In:house!production!unlikely.!
NA!
NA!
Global,!128!countries.!
+++!
+!
:!
Alltech!is!a!manufacturer!and!supplier!of!animal!feed!and!feed!additives.!
Products:!
Phytase!
Xylanase!
Protease!
Cellulase!
Beta:glucanase!
Amylase,!pentosanase,!pectinase!
!
!
!
58!
!
!
!!
!
Almac'Sciences'
http://www.almacgroup.com/!!
Almac!House!
20!Seagoe!Industrial!Estate!
Craigavon!BT63!5QD!
UK!
Tel:!+44!28!3833!2200!
Fax:!+44!28!3833!2299!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
2001!
3,300!
Private,!owned!by!Alan!McClay!Foundation!
Low!percentage!of!total!sales!
Biocatalysis!
Company!literature!cites!a!‘diverse!range!of!micro:organisms’!and!this!would!
include!E.,coli,
Grams!to!multi:Kg!scale!in:house!production!(larger!scale!with!partner!DSM!
possible)!
Stephen!Barr,!PhD,!President!and!Managing!Director;!Denis!Geffroy,!VP,!
Business!development;!Tom!Moody,!!Head!of!Biocatalysis!&!Isotope!
Chemistry!
DSM!(DSM!and!Almac!have!access!to!each!other’s!enzyme!collections!in!a!
collaboration!that!began!in!2012.)!University!College!of!London!and!Queens!
University!are!partners!for!biocatalysis!research.!
600+!companies!worldwide,!Pfizer!
+++!(Almac!has!been!growing!organically!and!states!that!it!is!profitable!and!
stable)!
+++!(Offerings!are!growing)!
+++!!Via!the!partnership!with!DSM,!Almac!manufactures!on!a!relatively!small!
scale!up!to!100s!of!g!or!low!Kgs!of!enzyme!(larger!amounts!of!chemical!
intermediates!and!APIs),!and!transfers!manufacturing!to!DSM!or!other!
partners!for!larger!orders.!Also!potent!compound!capabilities!using!chemo:
biocatalytic!methods.!
!
!
59!
!
!
!!
Based!in!Craigavon,!UK!(near!Belfast,!Northern!Ireland),!Almac!Sciences!is!a!contract!research!
organization!for!the!pharmaceutical!industry!offering!a!broad!array!of!services!to!support!
pharmaceutical!developments!from!concept!to!product!launch.!Almac!is!a!relatively!new!entrant!in!the!
field!of!biocatalysis,!using!enzymes!and!biocatalysts!to!further!expand!the!scope!of!its!pharma!services!
to!include!enzymatic!process!development.!As!of!2013,!Almac!has!developed!its!capatilities!in!enzyme!
discovery,!evolution,!and!biocatalysis!to!be!one!of!the!leading!companies!in!the!field!worlwide.!!Aimed!
primarily!at!applications!for!the!synthesis!of!pharmaceutical!intermediates,!Almac!has!quickly!
established!its!reputation!for!high!quality!and!excellent!service.!!Almac!has!branded!its!enzymes!and!
technology!as!the!SelectAZymeTM!platform.!
Almac!offers!to!either!conduct!R!&!D!using!biocatalysts!for!route!development!using!in!house!enzymes,!
or!to!provide!off!the!shelf!enzymes!directly!to!the!customer.!!The!company!offers!enzyme!kits!with!
collections!of!enzymes!as!follows:!
Carbonyl!Reductase!:!CESK:6000!(60!enzymes)! !
Hydrolase!:!HESK:4800!(48!enzymes)!
!
Nitrile!Manipulators!:!NESK:2400!(24!enzymes)! !
Nitrilase!:!NiTESK!1500!(15!enzymes)!
Nitrile!Hydratase!:!NiHESK!900!(9!enzymes)!
Aldehyde!Reductase!:!AESK:1600!(16!enzymes)! !
Transaminase!:!TESK:3600!(36!enzymes)!!
Phenylalanine!Dehydrogenase!–!PDESK:500!(5!enzymes)!!
Amine!Oxidase!–!AoESK:800!(8!enzymes)!
Epoxide!Hydrolase!–!EHESK:500!(5!enzymes)!
!
P450!Monooxygenase!–!OxESK:1000!(10!enzymes)!
Ene!Reductase!–!ERESK:1300!(13!enzymes)!
!
!
Hyperactivated!Hydrolase!–!HAHESK:1000!(10!enzyme)!
Human!P450!monooxygenase!–!HosESK:1000!(10!enzymes)!
In!2012,!Almac!began!offering!screening!and!scale!up!services!for!producing!and!identifying!drug!
metabolites!using!a!collection!of!cytochrome!P450!enzymes!and!related!catalysts.!!!
!
!
60!
!
!
!!
Alpha'Diagnostic'International,'Inc.'
http://www.4adi.com/!!
6203!Woodlake!Center!!
San!Antonio,!Texas!78244!!
USA!
Tel:!+1:800:786:5777!!
Tel:!+1:210:561:9515!!
Fax:!+1:210:561:9544!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
5:20!employees!
Private!
Small!
Diagnostics!
NA!
No!manufacturing!in!house!
NA!
NA!
NA!
NA!
++!
:!
From!the!website:!“Alpha!Diagnostic!International!(ADI)!located!in!San!Antonio,!Texas,!USA,!is!a!major!
provider!of!custom!services!such!as!peptides!synthesis!and!polyclonal!antibodies.!ADI!specializes!in!the!
development,!manufacture,!and!distribution!of!variety!of!ELISA!reagents!and!kits!for!animal!and!human!
research.!ADI!maintains!an!USDA!inspected!and!approved,!animal!facility.!We!have!introduced!a!number!
of!specialized!anitbodies!to!a!variety!of!new!genes!including!obese/leptin,!membrane!receptors,!and!
neurotransmitter!transporters.”!
Products:!
Acylase!
Alkaline!phosphatase!
!
61!
!
!
!!
Butrylylcholine!esterase!
Beta:glucosidase!
Beta:glucuronidase!
Carbonic!anhydrase!
Catalase!
Cholesterol!oxidase!
Creatinase!
Deoxyribonuclease!
D:amino!acid!oxidase!
Glucose!oxidase!
Peroxidase!
Hyaluronidase!
Lactate!dehydrogenase!
Mutarotase!
Pepsin!
Pyruvate!kinase!
Pyranose!oxidase!
Ribonuclease!
!
!
'
'
!
62!
!
!
!!
Amano'Enzyme'
http://www.amano:enzyme.co.jp/!!
1:2:7,!Nishiki,!Naka:ku!
Nagoya!460:8630!!
Japan!!
Tel:!+81:(0)52:211:3032!!
Fax:!+81:(0)52:211:3054!
Email:!www:info@amano:enzyme.ne.jp!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
1899!(parent!company),!1948!(Amano!Enzyme),!1981!(Amano!USA)!
440!employees!
Private!
Almost!all!sales!are!enzymes,!a!small!amount!is!yeast!extract!
Pharmaceutical,!food!processing,!dietary!supplement,!nutraceutical,!
biotransformation,!and!diagnostics.!
A!variety!of!culturable!organisms!
Muliton!scale,!Amano!owns!about!4!large!manufacturing!plants!in!Japan!and!
China!
Motoyuki!Amano,!President!
NA!
NA!
++!(estimated)!
+++!(extensive!catalog!of!enzymes!across!many!fields)!
+!(though!not!advertised!as!a!service,!Amano!has!produced!enzymes!for!
others!including!Altus)!
!
Amano!Enzyme!Inc.,!along!with!its!subsidiaries,!develops,!produces,!and!sells!enzymes!for!
pharmaceutical,!food!processing,!dietary!supplement,!nutraceutical,!biotransformation,!and!diagnostic!
industries!in!Japan.!It!offers!medical!and!food!processing!enzymes!that!are!used!in!digestive!aid!
products,!antiinflammatory!enzyme!preparations,!chiral!synthesis,!diagnostic!kits,!dairy!products,!
seasonings,!alcoholic!drinks,!and!breads.!The!company!also!offers!non:animal!and!non:GMO!enzymes!in!
the!United!States,!Canada,!and!Central!and!South!America;!and!animal!organ!extracts.!Its!enzymes!are!
also!used!in!proteins!processing,!starch!processing,!yeast!extract!manufacturing,!oil!and!fat!processing,!
and!others.!The!company!was!founded!in!1899!and!is!based!in!Nagoya,!Japan!with!locations!in!Japan,!
the!United!States,!the!United!Kingdom,!Switzerland,!Mexico,!China,!and!Malaysia.!
!
63!
!
!
!!
In!biocatalysis!Amano!was!the!developer!of!one!of!the!best!known!lipases!for!resolution!of!chiral!esters,!
carboxylic!acids,!and!alcohols:!Lipase!PS!(originally!from!Pseudomonas,cepacia).!
For!food,!diagnostics,!and!biocatlaysis,!Amano!Enzyme!USA,!Inc.!is!an!important!division.!As!a!subsidiary!
of!Amano!Enzyme,!Inc.,!Japan,!Amano!Enzyme!USA!supplies!the!North!and!South!American!markets!with!
high!quality,!non:animal!and!non:GMO!enzymes!for!the!dietary!supplement,!nutraceutical,!food,!
diagnostic!and!pharmaceutical!industries.!
Amano!Enzyme!USA!
2150!Point!Boulevard,!Elgin,!IL!60123!!
[email protected][email protected]!!
847:649:0101!
Products:!
Amano!offers!enzymes!in!the!following!product!categories:!
Acylases!!
Lipases!
Lipoprotein!lipase!
Glycerol!kinase!
L:alpha:glycerophosphate!oxidase!
Cholesterol!dehydrogenase!
Glucose!oxidase!
Malate!dehydrogenase!
Bilirubin!oxidase!
Ascorbate!oxidase!
Peroxidase!
Uricase!
Collagenase!
!
64!
!
!
!!
Hyaluronidase!
Proteases!
Glutaminase!
Laccase!
Lactase!
Hyderase!
Dextranase!
Catalase!
Cellulase!
Diastase!
!
!
'
'
!
65!
!
!
!!
American'Biosystems,'Inc.'
http://www.americanbiosystems.com/!!
P.O.!Box!1523!
Roanoke,!VA!24007!
USA!
Tel:!+1:540:344:6469!
Tel:!+1:888:344:6469!!
Fax:!+1:540:301:6451!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
11:50!employees!
Private!
Important!minority!revenue!source.!
Animal!feed,!textiles!
Trichoderma,reesei,,Trichoderma,sp.,,Trichoderma,viridue,,Pichia,pastoris,,
Aspergillus,oryzae,,Bacillus,subtilis.,
Bulk,!no!in:house!production.!
Edward!Goyette,!President!
NA!
NA!
NA!
+!(about!10!entries)!
NA!
“American!Biosystems,!Inc.!specializes!in!the!production!of!direct:fed!microbials.!!Microbials!can!be!used!
in!a!variety!of!different!applications.!Some!are!used!for!animal!feed!and!aquaculture!products.!Others!
are!used!in!domestic,!municipal!and!industrial!waste!treatment!products.!Concentrated!enzyme!
products!are!useful!in!both!agricultural!and!industrial!applications.”!!!
Products:!
Amylases!
Beta:glucosidase!
!
66!
!
!
!!
Cellulase!
Hemicellulase!
Lipase!
Xylanase!
Phytase!
Beta:mannase!
'
'
!
67!
!
!
!!
American'Laboratories,'Inc.''
www.americanlaboratories.com!!
4410!South!102nd!Street!!
Omaha,!Nebraska!68127!!
USA!
Tel:!+1:402:339:2494!!
Fax:!+1:402:339:0801!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1967!
30:50!employees!
Private!
Major!revenue!source.!
Animal!nutrition,!diagnostics,!food.!
Enzymes!are!isolated!from!natural!materials,!plants!or!animal!glands!
Three!buildings,!including!a!60,000!sq!ft!manufacturing!facility!
Jeff!Jackson,!CEO!
NA!
Global!
++!(estimate)!
++!(about!30!enzyme!products)!
+!(will!isolate!enzymes!from!animal!or!plant!material!for!customer)!
From!the!website:!“American!Laboratories,!Inc.!(ALI)!was!started!in!1967!in!Omaha,!NE.!ALI!is!a!specialty!
processor!of!Enzymes!(Pancreatin,!Pepsin,!Bromelain,!Papain,!Fungal!and!Custom!Fungal!Enzyme!
Blends);!Proteins!(Beef,!Pork!and!Chicken!Liver!Powders);!and!Peptones!(Casein!Hydrolysate,!
Microbiotone,!and!Proteose!Micro)!and!sells!to!customers!in!food!processing,!pharmaceutical,!
veterinary!health,!nutritional,!and!companion!animal!industries!in!45!countries!!around!the!world.!For!
more!information,!visit!www.americanlaboratories.com”!
Products:!
Pancreatin!
Pepsin!
Bromelain!
!
68!
!
!
!!
Papain!
Proteases!
Amylogucosidase!
Beta:glucanase!
Cellulase!
Amylases!
Lactase!
Lipase!
Glucose!oxidase!
Hemicellulase!
Invertase!
Maltase!
Penctinase!
Phytase!
Xylanase!
Diastase!
Trypsin!
'
'
!
69!
!
!
!!
Americos'Industries'Inc.'
http://www.kenencoregroup.com/!!
B/610/611,!Ganesh!Plaza!
Nr.!Navrangpura!Post!Office!
Ahmedabad!:!380!009,!Gujarat!
India!
Tel:!+(91)!:!(79)!:!26447781/82,!26447736!
Fax:!+(91)!:!(79)!:!26447736!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
50!employees!
Private!
Important!minority!revenue!stream.!
Textiles!and!food.!
Fungal!and!bacterial!
Bulk.!!In:house!production!not!likely.!
NA!
NA!
NA!
NA!
+++!(Americos’!lists!of!enzymes!in!each!textiles!and!food!enzymes!are!very!
extensive)!
:!
From!the!website:!“Welcome!to!Americos!Industries!Incorporation,!Manufacturer!and!Supplier!of!
Chemical,!Auxiliaries,!Smart!Colorants,!Dyestuffs!and!Enzymes.!The!Company!was!incorporated,!at!
Ahmedabad.!We!have!spread!our!wings!to!UK,!USA!and!Indonesia.!Accurate!composition,!International!
quality!standards!and!excellent!logistic!support!are!the!factors!that!help!us!to!stay!ahead!of!our!
competitors.!We!offer!a!huge!gamut!of!Enzymes,!Colorants,!Dyestuffs,!Flavors!and!Probiotics.!Our!
organization!is!instrumental!in!offering!a!wide!gamut!of!Enzymes!and!Colorants.!Abrasives!offered!by!us!
are!in!huge!demand!across!the!global!markets.!We!also!provide!Dyestuffs,!Flavors!and!Probiotics!that!
are!best!in!the!industry!amongst!others.!Our!Softeners!and!Speciality!Chemicals!are!extremely!reliable.!
Along!with!that!we!offer!Finishes,!Auxiliaries!and!Brighteners!that!are!cost!effective.!For!more!
information!log!on!at:!http://www.kenencoregroup.com/”!
!
70!
!
!
!!
Products:!
Amylases!
Pectinases!
Cellulases!
Proteases!
Catalase!
Maltase!
Pentosnase!
Glucose!oxidase!
Lipases!
Phospholipase!
Beta:glucosidases!
Esterases!
!
'
'
!
71!
!
!
!!
Amit'Biotech'Pvt.'Ltd.'
Unit!No.!21,!3rd!Floor!
21,!Ballygunge!Circular!Road!
Kolkata!:!700019!
West!Bengal!
India!
Tel:!+91:33:24864118!
Fax:!+91:33:24866454!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1996!
51:200!employees!
Private!
Very!small!
Animal!nutrition!
NA!
Amit!Kumar!Rastogi,!Director!
NA!
NA!
NA!
+!
:!
Amit!is!a!manufacturer!and!distributor!of!a!broad!range!of!products!in!agriculture,!plantation,!animal!
and!fish!farming,!and!others.!!!
Products:!
Phytase,!Gluconase,!Pectinase,!Cellulase!
!
'
'
!
72!
!
!
!!
AMPLICON'
www.amplicon.cz!!!
Business!dept.!of!Forenzni!DNA!servis,!s.r.o.!
Budinova!2!
180!81!Praha!8!
Czech!Republic!
Tel:!+420!233!123!/!+420!731!503!250!
Fax:!+420!233!123!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
NA!
Small!
Life!science!enzymes!
NA!
No!in:house!production.!!Supplies!laboratory!quantities.!
NA!
Sells!enzymes!from!NZYTech.!
NA!
NA!
+!
:!
Amplicon!is!a!supplier!of!life!science!products.!!!
Products:!
Carbohydrate:active!enzymes:!feruloyl!esterase,!glucomannan!acetyl!esterase,!pectin!acetyl!esterase,!
xylan!acetyl!esterase,!arabinofuranosidase,!arabinoxylanase,!β:1,4:Glucosidase,!cellobiohydrolase,!
chitinase,!cellulases,!β:1,3(4):glucanase,!β:1,3:glucanase,!endo:β:1,4:galactanase,!endo:β:1,4:
galactanase,!exo:β:1,3:galactanase,!exo:β:1,4:mannanase,!mannanase,!endo:β:1,4:mannanase,!
mannosidase,!xylanase,!xyloglucanase,!α:galactosidase.!
Analytical!and!diagnostic!enzymes:!!
!
73!
!
!
!!
Acetyl:CoA!syntethase!
D:alanine!aminotransferase!!
Alcohol!dehydrogenase!
Aldehyde!reductase!
Arginase!
Aspartate!aminotransferase!
Citrate!synthase!
Glucokinase!
Glucose:6:phosphate!isomerase!
Glutaminase!
Lactadehyde!dehydrogenase!
D:lactate!dehydrogenase!
D:malate!dehydrogenase!
L:malate!dehydrogenase!
NADH!peroxidase!
Sulfite!oxidase.!
!
'
'
!
74!
!
!
!!
Ampliqon'A/S'
www.ampliqon.com!!
Stenhuggervej!22!!
5230!Odense!M!!
Denmark!
Tel:!+45!70!20!11!69!!
Fax:!+45!70!20!11!79!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
Small!
Private!
Important!minority!revenue!stream!
Life!science,!molecular!biology!
NA!
Laboratory!scale!
NA!
Distributors!in!many!countries.!
Global!
NA!
+!
:!
From!the!website:!“Ampliqon!is!a!small:scale!PCR!enzyme!and!bioreagent!manufacturer.”!
Products:!
DNA!Polymerases!(Recombinant!Taq)!
!
!
!
'
'
!
75!
!
!
!!
ANC'Enzyme'Solutions'
http://www.ancenzymes.com/!!
20!Cecil!St,!#14:01!Equity!Plaza!
Singapore,!049705!
Singapore!
Tel/Fax:!+6566185774!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
11:50!
Private!
Major!revenue!source.!
Textiles,!Pulp!and!Paper,!Starch!and!related!Industries,!Brewing,!Potable!and!
Industrial!Alcohol,!Fruit!Juice/Wine!and!Seed/Essential!Oil!Extraction,!Waste!
Tratment!and!Animal!Feed!
Aspergllus,niger,,Bacillus,subtilis,
Bulk,!a!distributor!only;!no!manufacturing!
NA!
NA!
Asia!
NA!
++!
:!
From!the!web!site:!“ANC!Enzymes!Solutions!Pte.!Ltd.!is!a!privately!owned,!Singapore!based!organization!
with!Joint!Ventures!in!India!and!Indonesia.!The!strength!of!ANC!Enzyme!Solutions!Pte.!Ltd.,!in!our!
chosen!Industries!of!operation,!arises!from!specific!hands!on!experience!and!first!hand!knowledge!of!the!
various!working!parameters!of!the!individual!processes.!!
Our!team!has!extensive!experience!in!Textiles,!Pulp!and!Paper,!Animal!Feed,!Juice!and!Wine,!Brewing,!
Potable!and!Industrial!Alcohol,!Wine!and!Edible!Oils.!Also!involved!in!Food,!Seafood/Shrimp!and!Pharma!
applications.!We!not!only!have!the!experience!in!applying!various!enzymes!to!these!industries,!we!also!
have!been!active!in!many!industries!applying!the!complimentary!Auxiliary!Chemicals!and!Additives!for!
the!various!processes.”!
!
!
76!
!
!
!!
Products:!
Amylases!
Xylanase!
Beta:glucosidase!
Mannase!
Pectinases!
Proteases!
Papain!
Laccase!
Phytase!
!
!
!
77!
!
!
!!
Andrés'Pintaluba,'S.A.'''''
www.pintaluba.com!!
www.myaenzimas.com!(subsidiary!that!registers!and!markets!the!enzymes)!
Edificio!Grupo!Pintaluba!
Polígono!Industrial!Agro:Reus!
Prudenci!Bertrana,!5!
E:43206!Reus!
Spain!
Tel:!+34!977!317!111!
!
!
Fax:!+34!977!323!188!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1978!
Medium!to!large!company!
Private!
Animal!nutrition!
NA!
NA!
Enzymes!manufactured!by!partner!GNCBioferm!in!Canada.!!Azelis!distributes!
products!in!UK.!
European!market,!Brazil,!Libya,!Argentina.!
NA!
+!
:!
From!the!website:!“The!company,!which!initially!focused!on!marketing!additives,!currently!
manufactures!and!markets!additives!and!medicated!premixes!for!animal!feed,!nutrition!and!health,!
growing!organically!and!developing!in!this!sector!and!in!new!related!fields.”!
Products:!
Pig!and!poultry!enzyme!mixture!formulations!containing:!Beta:glucanases,!Beta:xylanases,!Alpha:
amylases,!Phytases!
!
78!
!
!
!!
Anil'Bioplus'
http://www.anilbioplus.com/!!
P.O.!Box!:!10009!
Anil!Road,!Ahmedabad!380025!
Gujarat!!
India!
Tel:!+91(79)22203222!
Tel:!+91(79)22200731!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1939!
>1000!employees,!ca.!$100!million!in!annual!revenues!
Public!
Major!revenue!stream!
Applications!in!fruit!juices,!brewing,!feed,!food,!pulp!and!paper,!leather,!and!
textiles.!!!
NA!
Multi:ton!
Shri!Amol!S.!Sheth,!Director!of!the!Company!
NA!
NA!
+++!
++!!
:!
Anil!Bioplus!is!a!public!company!associated!with!the!large!Indian!conglomerate!Anil!Group.!!The!Anil!
Group!is!an!association!of!companies!in!everything!from!real!estate,!to!starch!and!milling,!to!enzymes!
and!ingredients,!industrial!machinery,!and!more.!!!
From!the!website:!“Anil!Bioplus!Limited!(ABL)!is!a!pioneer!in!manufacturing!of!Industrial!Enzymes,!
Microbes!(with!enzymes)!and!Bio:Chemicals!(Calcium!&!Sodium!Gluconate)!through!fermentation!
process,!developed!by!in:house!Research!&!Development!Laboratories.!The!company!manufactures!
different!grades!of!enzymes!for!end:user!industries!like!Textile,!Paper,!Food!&!Beverages,!
Pharmaceuticals,!Feed,!Distilleries!etc.!and!Mineral!Gluconates,!which!are!used!as!source!of!energy!in!
!
79!
!
!
!!
veterinary!applications,!construction!and!chemical!industries.!The!range!of!enzymes!is!marketed!in!both!
India!and!international!destinations!through!dedicated!marketing!teams.!
With!growing!globalization!and!increasing!requirements!for!customized!solutions,!the!Application!
Development!Cell!at!Anil!Bioplus!works!closely!with!R&D!department!to!provide!the!necessary!support!
in!improving!the!customer's!manufacturing!efficiencies!and!the!overall!end!product!quality.!Another!key!
function!of!this!cell!is!to!identify!applications!and!areas!for!introducing!new!products!and!new!
applications!for!the!existing!products!to!expand!the!markets!and!create!newer!horizons!for!business.!
The!cell!also!provides!support!in!trouble!shooting!and!other!technical!services!to!its!customers.!Cell!is!
manned!by!specialists!in!end!user!industry.!
The!company,!through!continuous!interaction!with!Research!&!Development!fraternity,!is!steadily!
making!efforts!towards!technology!absorption,!adoption!and!innovation.!The!thrust!areas!have!been!
ongoing!improvement!of!quality!of!products,!increase!in!productivity!through!costs!and!development!of!
new!related!products!for!various!end!uses.”!
Products:!
Amylases!
Cellulase!
Catalase!
Pectinase!
Proteases!
Phytase!
Galactosidases!
Glucoamylases!
!
'
'
!
80!
!
!
!!
Anthem'Cellutions'
http://www.anthemcell.com/!!
F1&F2,!Canara!Bank!Road!
Bommasandra!Industrial!area!Phase!I!
Hosur!Road,!Bangalore!:560099!
India!
Tel:!+91:80:40444000/66724000!
Fax:!+91:80:40444020/66724020!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
Parent!company!has!over!400!employees.!
Private,!a!division!of!Anthem!BioSciences!
Enzymes!for!baking,!fruit!juice!processing,!starch!processing,!textiles,!
detergents,!leather,!pulp!and!paper,!and!oil!field!applications.!!!
NA!
Large!
Ajay!Bharadwaj,!CEO!
One!supplier!of!Anthem’s!offerings!is!Verenium!through!WeissBiotech!
NA!
NA!
++!
NA!
From!IRCA!Lt!credit!rating:!“Anthem!Cellutions!(India)!Limited!is!primarily!engaged!in!the!manufacturing!
and!processing!of!nutraceutical!products,!enzymes!and!actives!for!various!applications!in!healthcare,!
food!&!beverages,!textiles,!detergents!and!animal!health!industries!etc.!!The!Company!derives!majority!
of!its!revenues!from!the!nutraceutical!and!animal!feeds!segment.!!Presently,!the!company’s!
manufacturing!facility!is!situated!in!Bommasandra!Industrial!Area!in!Bangalore!where!the!company!
manufactures!actives,!enzymes!and!probiotics.!Along!with!the!associated!concern!ABPL,!ACIL!employs!
over!400!employees!including!over!200!scientists!who!work!!towards!developing!differentiated!
molecular!formulations.!Using!these!capabilities,!the!Company!focuses!on!producing!niche!variants!of!
already!existing!products.”!
!
81!
!
!
!!
Products:!
Proteases!
Papain!
Pectinases!
Amyloglucosidases!
Amylases!
Glucoamylases!
Cellulases!
Xylanases!
Lipases!
Catalase!
Mannase!
!
'
'
!
82!
!
!
!!
Apollo'Chemical'Company'
http://www.apollochemical.com/!!
2001!Willow!Springs!Lane!
Burlington,!NC!27215!
USA!
Tel:!+1:336:226:1161!
Fax:!+1:336:570:6246!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1968!
NA!
Private!
Small!
NA!
NA!
NA!
NA!
NA!
NA!
+!
NA!
From!the!website:!“Our!products!supply!the!Graphic!Arts,!Carpet,!Coatings,!Industrial!Chemicals,!
Apparel,!Hosiery,!Denim,!Automotive!Fabric,!and!Home!Furnishings!markets.”!
Products:!
Listed!are!“enzymes”!and!“scouring!enzymes”(e.g.!pectinase)!and!catalase!
'
'
!
83!
!
!
!!
Apollo'Scientific'
http://www.apolloscientific.co.uk/!!
Apollo!Scientific!Ltd,!Whitefield!Rd!
Bredbury,!Stockport,!Cheshire,!SK6!2QR!
UK!
Tel:!+44!(0)161!406!0505(5!lines)!
Fax:!+44!(0)161!406!0506(4!lines)!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1993!
11:50!
Private!
Small!
A!diverse!selection!of!188!enzymes!is!offered.!!Applications!include!cofactor!
regeneration,!life!science/DNA!manipulation,!diagnostics,!and!biocatalysis.!
NA!
Lab!scale,!distributor!only!
NA!
Many!suppliers.!
Global!
NA!
++!
:!
Apollo!is!a!supplier!of!laboratory!chemicals,!and!it!supplies!laboratory!amounts!of!enzymes!as!a!
distributor.!
Products:!
Extensive!list,!188!different!enzymes!for!research!
!
!
!
'
'
!
84!
!
!
!!
Applied'Biotechnology'Institute'
http://www.appliedbiotech.org/!!
Cal!Poly!Technology!Park!
Building!83:1D!
San!Luis!Obispo,!CA!93407:3405!
USA!
Tel:!+1:805:756:6458!!!!!!!!!!!!!!!!!!!!!!!!!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Mid:!to!late:2000’s!
1:10!employees!
Private!
none!
NA!
Recombinant!production!in!plants!including!corn!
NA!
John!Howard,!Founder!and!President!
Works!with!Infinite!Enzymes!to!produce!a!cellulose:degrading!enzyme!in!
corn!seed.!
NA!
NA!
:!
+!(small!scale)!
From!the!website:!“ABI!is!a!research!company!that!develops!new!product!concepts!and!performs!early!
stage!product!development.!ABI!partners!with!other!companies!for!latter!stages!of!product!
development,!production!and!sales.!ABI!uses!its!platform!technology!is!to!express!recombinant!proteins!
that!provide!health!and!environmental!benefits!to!society.!!ABI!takes!advantage!of!the!unique!
characteristics!of!plants!to!overproduce!recombinant!proteins.!In!particular,!it!selects!proteins!that!are!
suited!for!this!particular!technology!to!achieve!an!advantage!over!traditional!methods!of!over:
expressing!proteins.!!ABI’s!system!of!choice!is!maize!grain!to!produce!recombinant!proteins.!!In!addition!
to!the!general!features!of!maize!grain!that!make!it!attractive,!ABI!has!issued!and!pending!patents!that!
favor!high!expression.”!
!
!
!
85!
!
!
!!
Archaezyme'Ltd'
http://www.archaezyme.com/!!
16!Hacharash!Street,!Room!213!
Ness!Ziona!70!400!
Israel!
Tel:!+972:8:940:6210!
Fax:!+972:8:940:9819!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1996!
1:10!employees!
Private!
NA!
Enzymes!are!in!development!for!the!synthesis!of!oligosaccharides!including!
polyphosphate!glucokinase!(PPGK)!and!polyphosphate!kinase!(PPK).!!
Thermostable!enzymes!from!thermophilic!organisms.!
NA!
Small!
Mathew!Weisman,!CEO!
NA!
Markets!worldwide!
NA!
+!(2!products!in!development)!
+!(small!operation)!
Archaezyme!Ltd.,!is!a!contract!enzyme!developer.!!The!company!offers!biochemistry!services!in!purifying!
and!analyzing!proteins,!and!offers!consulting!services!in!enzyme!applications.!!Archaezyme!is!named!as!
such!because!it!has!investigated!stable!enzymes!from!thermophiles.!!The!company!appears!to!be!a!small!
1:2!person!firm.!
Products:!
Polyphosphate!glucokinase!(PPGK)!
Polyphosphate!kinase!(PPK)!
'
'
!
86!
!
!
!!
ArcticZymes'
http://arcticzymes.com/!!
Sykehusveien!23!
9019!Tromsø!
Norway!
Tel:!+47!77!64!89!00!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2009!
About!25!employees!
96%!owned!by!public!company!Biotec!Pharmacon!ASA!(Oslo!Stock!Exchange!
under!the!BIOTEC!ticker!symbol)!
Enzyme!sales!are!about!75%!of!revenue,!remainder!is!government!grants!
Molecular!biology!and!diagnostics.!!Heat:labile!enzymes.!!!
Shrimp!alkaline!phosphatase!originally!isolated!from!shrimp!now!produced!
recombinantly!in!Pichia,pastoris.!!E.,coli!(ung:)!for!Cod!UNG.!!SAN!and!
dsDNase!produced!recombinantly!in!Pichia,pastoris.!
Laboratory!to!kg!scale!
Svein!W.!F.!Lien,!CEO!(also!CEO!of!parent!company!Biotech!Pharmacon)!
GE!Healthcare!Life!Sciences;!Percorso!Life!Sciences,!LLC!located!in!Plymouth!
Meeting,!PA!for!establishment!of!USA!branch!of!company;!New!England!
Biolabs!and!Affymetrix!Inc!for!distribution!of!products;!Research!Council!of!
Norway!for!funding!of!multiple!projects!
Global!through!distributors!
+!(small!operating!loss,!parent!company!recently!raised!capital)!
+!(small!catalog,!valuable!well:selling!enzymes)!
:!
From!the!company!website:!!
“ArcticZymes!AS!has!a!long!history!dating!back!to!the!late!1980’s!with!its!foundation!firmly!planted!in!
the!fishing!industry!of!Northern!Norway.!In!the!mid:1990’s!Biotec!Pharmacon!acquired!the!technology!
for!production!of!Shrimp!Alkaline!Phosphatase!and!built!a!department!for!production!of!molecular!
grade!enzymes.!In!June!2009!Biotec!Pharmacon!created!ArcticZymes,!a!96%!owned!subsidiary.!
ArcticZymes!has!a!rich!history!in!the!ability!to!leverage!its!access!to!the!marine!Arctic;!identify!novel!
cold:adapted!enzymes!for!us!in!molecular!research!and!diagnostics,!manufacture,!and!commercialize!
our!enzyme!portfolio.”!
!
87!
!
!
!!
Products:!
Shrimp!alkaline!phosphatase!
Cod!Uracil:DNA!Glycosylase!(Cod!UNG)!
dsDNase!
Salt!Active!Nuclease!(SAN)!
Kits!of!the!preceding!enzymes!
!
'
'
!
88!
!
!
!!
Ares'Bioscience'GmbH'(Genecraft)'
http://www.genecraft.de/!!
Graeffstr.!5!
50823!Köln!
Germany!
Phone:! +49!(0)221!17072583!
Fax:!+49!(0)221!17072585!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1996!
NA!
Private!
NA!
Life!science!enzymes:!restriction!enzymes,!polymerases.!
NA!
Lab!scale!
Dimitrij!Plachov,!CEO!
NA!
NA!
NA!
+++!(extensive!catalog)!
:!
The!most!recent!catalog!on!the!website!of!Genecraft!dates!to!2008,!so!there!is!some!doubt!to!whether!
or!not!this!company!remains!in!existence.!!
From!the!company!website:!“GENECRAFT!is!an!German!biotechnology!company!that!markets!molecular!
biology!products.!Since!its!founding!in!1996,!the!company!continues!to!expand!its!marketing!worldwide.!
Our!growth!has!been!built!on!long!term!experience!of!Russian!scientists!in!the!development!and!
production!of!unique!molecular!biology!products.!As!a!result,!we!are!able!to!supply!the!life!sciences!
market!with!inexpensive,!top!quality!products,!generally!at!half!the!cost!of!competitive!products!on!the!
European!market.!
Its!core!competencies!encompass!several!areas:!PCR!and!PCR:based!technologies;!cDNA!technologies;!
gene!analysis;!and!nucleic!acid!chemistry.!
!
89!
!
!
!!
Recently,!the!company!has!released!a!number!of!innovative!products.!The!list!of!restriction!enzymes!
offered!by!GENECRAFT!includes!some!unique!isoschizomeres,!not!provided!by!other!suppliers.!Several!
tools!and!kits!for!molecular!biology!are!also!offered.”!
Products:!
Restriction!enzymes!
DNA!Polymerases!
!
'
'
!
90!
!
!
!!
Arun'and'Co'
http://www.arunandco.com/!!
Polaris,!6th!floor!
Off!Marol!Maroshi!Road,!Behind!Sangeet!Plaza!
Marol,!Andheri!(east)!
Mumbai!:!400!059!
India!
Tel:!+91:22:6772!3000!!
Fax:!+91:22:6725!3399!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1947!
5:10!million!USD!
Private!
Important!minority!revenue!source.!
Diagnostics,!molecular!biology!
Limited!!
Likely!no!in:house!production!
NA!
Suppliers:!Novozymes!A/S,!Denmark;!Dishman!Netherlands!B.V.!(formerly!
Solvay);!BBI,!U.K.;!Organo!Technie!S.A.,!France,!Worthington!Biochemical!
Corporation,!USA;!Institut!Rosell!/!Lallemand,!Canada;!Boval!Company,!USA;!
Kem:en:tec,!Denmark!
“rich!list!of!customers,!which!includes!almost!all!leading!companies!in!
pharmaceutical,!textile,!diagnostics,!oil,!starch,!baking!and!other!industries”!
in!India!
++!(estimation!based!on!company!size,!long!history!and!distribution!model)!
+++!
:!
Arun!and!Co.!began!as!a!distributor!for!enzymes!from!international!manufacturers,!and!continues!to!
operate!primarily!as!a!distributor.!The!company!is!a!primary!manufacturer!for!only!a!few,!if!any,!enzyme!
products,!buying!n!the!enzymes!it!sells!from!Novozymes,!BBI,!and!others.!!Product!offerings!have!
expanded!beyond!enzymes!to!include!a!range!of!biology:based!products.!
!
91!
!
!
!!
From!the!company!website:!“Arun!&!Co.!currently!develops,!manufactures!and!markets!a!wide!range!of!
products!including!enzymes!of!diagnostics,!research!&!industrial!grades,!biochemicals,!probiotics,!
enzyme!/!probiotic!formulations!and!reagents!for!research!&!diagnostics.!!Arun!&!Co.!has!set!up!a!full:
fledged!laboratory!for!its!R&D!activities!in!the!commercial!capital!of!India,!Mumbai!alongside!its!
corporate!office.!From!the!very!inception,!Arun!&!Co.!has!believed!in!building!a!strong!base,!not!only!for!
new!products,!but!also!for!application!technology.”!
Products:!
Elastase!
Enterokinase!
Leucine!aminopeptidase!
Pepsin!
Prolidase!
Trypsin!
Acetylcholinesterase!
Acylase!
Arginase!
Butyrylcholine!esterase!
Carbonic!anhydrase!
Catalase!
Hyaluronidase!
Lactoperoxidase!
Lipoxidase!
Superoxide!dismutase!
Triose:phosphate!isomerase!
Xanthine!oxidase!
Alpha:amylase!
!
92!
!
!
!!
Alpha:glucosidase!
Deoxyribonucleases!
Lysozyme!
Ribonuclease!
Collagenase!
Alcohol!oxidase!
Aldehyde!dehydrogenase!
Aminolevulinate!dehydratase!
Ascorbate!oxidase!
Cholesterol!esterase!
Glucose!oxidase!
Beta:glucosidase!
Glyceraldehyde:3:phosphate!dehydrogenase!
Hexokinase!
Lipoamide!dehydrogenase!
Mutarotase!
Peroxidase!
Phosphoenolpyruvate!carboxylase!
Pyruvate!kinase!
!
93!
!
!
!!
Urease!
Xanthine!oxidase!
Phosphatase!
Creatine!kinase!
Glutamic:oxaloacetic!transaminase!
Glutamic:pyruvic!transaminase!
Gama:glutamyl!transferase!
!
'
'
!
94!
!
!
!!
ASA'Spezialenzyme'GmbH'
http://www.asa:enzyme.de/!!
Am!Exer!19c!
38302!Wolfenbüttel!
Germany!
Tel:!+49!(0)!5331!8825:30!
Fax:!+49!(0)!5331!8825:32!
Email:!grotrian@asa:enzyme.de!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1991!
ca.!10:20!employees!
Private!
Food!and!feed,!pulp!and!paper,!textiles,!biocatalysis,!biopolymer!
degradation,!biofuels.!!!
Bacillus,,Aspergillis,,Trichoderma,,Kluvyermyces,,Pichia,,Rhizopas,,Candida,,E.,
coli,,Rhodococcus,!others.!
Bulk,!in:house!production!likely.!
Arno!Cordes,!Founder!
Has!collaborated!with!academia,!has!participated!in!government!grants.!
NA!
++!(estimated!to!be!profitable,!long!history)!
+++!(wide!range!of!typical!and!hard:to:find!enzymes)!
++!(offers!R+D!services,!can!produce!batch!amounts)!
ASA!earns!a!substantial!portion!of!its!revenue!from!bacteria!mixed!cultures!for!pond!and!lake!water!
quality!management.!!The!company!manufactures!a!diverse!group!of!enzymes!in!an!equally!diverse!set!
of!expression!hosts.!!!
From!the!company!website:!“The!business!activities!of!ASA!Spezialenzyme!GmbH!cover!the!
development,!production!and!marketing!of!enzymes,!microbial!mixed!cultures!and!other!
biotechnological!products.!Since!the!foundation!in!the!year!1991!we!have!continuously!developed!our!
competence!in!the!area!of!special!enzymes.!Our!product!range!covers!the!fields!of!application!in:!food!
and!feed!processing,!organic!synthesis,!analytics,!biosensors,!textile!industry,!paper!industry.!In!the!area!
of!mixed!cultures!we!offer!products!for!industrial!and!private!use.!The!main!applications!for!
!
95!
!
!
!!
microorganisms!are!the!lake!and!pond!restoration!as!well!as!the!improvement!of!water!quality!in!
aquariums,!garden!ponds!and!commercial!aquacultures.”!
Products:!
Proteases!
Pectinase!
Lactase!
Lipase!
Cellulase!
Amylases!
Alcohol!oxidases!
Chitinase!
Chlorperoxidase!
Esterases!
Laccases!
Peroxidase!
Phytase!
Tannases!
Penicillin!acylase!
L:Phenylalanine!dehydrogenase!
S:Oxynitrilase!
R:Oxynitrilase!
Manganese!peroxidase!
L:Leucine!dehydrogenase!
!
'
'
!
96!
!
!
!!
Asahi'Kasei'
http://www.asahi:kasei.com/!!
1:105!Kanda!Jinbocho,!Chiyoda:ku!
Tokyo!101:8101!
!Japan!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1931!(parent!company)!
28,000!employees!(parent!company)!
Public!
Small!
Diagnostics!
A!wide!range!of!native!and!recombinant!hosts!including!Arthrobacter,,
Pseudomonas,,Pyrococcus,,Candida,,Acremonium,,Bacillus,,Rhodococcus,,
Streptococcus,,Chromobacterium,,Vibrio,,Geobacillus,!etc.!!
NA!
NA!
Global!
+++!(large!public!company)!
+++!(about!50!enzymes)!
:!
Through!its!subsidiary!Asahi!Kasei!Pharma,!the!parent!company!Asahi!Kasei!sells!enzymes!for!diagnostic!
applications.!!Asahi!Kasei!offers!a!large!product!range!in!the!diagnostic!enzyme!market.!
Products:!!
Lipases!
Kinases!
Aminotransferases!
Amylases!
Alkaline!phosphatases!
Dehydrogenases!
Uricase!
!
97!
!
!
!!
Tyramine!oxidase!
Sphingomyelinase!
Pyruvate!oxidase!
Isomerases!
Phospholipases!
Phosphorylases!
Hexokinses!
Daphorase!
Cholesterol!oxidases!
Bilirubin!oxidase!
Alcohol!oxidase!
!
'
'
!
98!
!
!
!!
AUM'Enzyme'
30,!Bhakti!Nagar,!Nr.!Jalaram!Mandir!
BORSAD:388!540!
Dist.!Anand.!(Gujarat)!!
India!
Tel:!+91:2696:221891:!9898383455!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
NA!
Textiles,!leather,!animal!feed,!baking,!detergents,!alcohol!production,!starch!
processing,!brewing,!waste!water!treatment.!!
Bacillus,,Trichoderma,,Aspergillus,
NA!
NA!
NA!
NA!
++!
:!
From!the!company!web!site:!“Aumenzymes'is!a!metabolic!engineering!firm!specializing!in!generally!
regards!safe!microbial!origin!industrial!technical!grade!enzymes!produced!by!solid!state!fermentation!
and!submerge!fermentation.!The!firm's!core!skills!are!total!enzymes!solution!under!one!roof.!AUM'
Enzyme!has!been!serving!the!needs!of!technical!grade!enzymes!users!in!various!field!viz.!Like!Enzymes!
for!Textile!Industry,!Enzymes!for!Leather!Industry,!Enzymes!for!Animal!Feed!Industry,!Enzymes!for!
Baking!Industry,!Enzymes!for!Detergent,!Enzymes!for!Alcohol!Industry,!Enzymes!for!Starch!Processing,!
Enzymes!for!Brewing!Industry,!Enzymes!for!Protein!Modification,!Enzymes!for!Effluent!
Treatment,!etcAUM!Enzymes!may!be!associated!with!Aumgene,!a!company!nearby!in!India.“!AUM!
Enzymes!claims!to!be!the!number!1!enzyme!producer!in!India.!
!
!
!
99!
!
!
!!
Products:!Extensive!list,!including!
Phytase!
Amylases!
Proteases!
Beta:glucanase!
Xylanase!
Cellulase!
Hemicellulase!
Catalase!
Lipases!
Peptidases!!
Glucoamylase!
Naraginase!
!
!
'
'
!
100!
!
!
!!
Aumgene'Enzyme'
http://www.aumgene.com/!!
Aumgene!Biosciences!Pvt.!Ltd.!
8201/5,!Road!No.!8!
GIDC!Sachin,!Surat!
India!
Tel:!+91:261:!3255755,!2399499!
Tel:!+91:9825062475,!9377755550!
Fax:!+91:261:2399409!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
5:10!employees!
Private!
Textile,!leather,!pulp!and!paper,!detergent,!fruit!juice,!baking,!animal!feed,!
brewing,!biofuels,!pharma,!biocatalysis.!
NA!
Fermenters!up!to!3000!L.!!In:house!production.!
Anand!Daga,!Founder!&!Director!
NA!
NA!
NA!
+!(wide!range!of!offerings)!
+++!(fermenters!up!to!3000!L)!
From!the!company!web!site:!“Aumgene!Biosciences!Pvt.!Ltd.!is!a!research!driven!Biotech!company!
based!in!Surat,!India.!The!company!focuses!on!development,!production!and!commercialization!of!
enzymes!and!microbial!products!through!classical!as!well!as!recombinant!approach.!The!company!has!
extensive!experience!in!development!&!manufacturing!of!enzymes.!The!company!has!commercialized!
several!enzymes!for!food,!pharma!,Industrial,!and!biocatalysis!applications.!The!company's!present!R&D!
product!pipeline!has!three!high!value!enzymes!in!late!stage!development.!The!company!also!offers!
contract!research!and!fermentation!process!development!&!manufacturing!services!to!clients!in!and!
outside!India.!
!
101!
!
!
!!
Aumgene!is!one!of!the!few!biotech!companies!in!India!with!R&D,!Pilot!and!Production!scale!
fermentation!infrastructure!under!the!same!roof.”!
Aumgene!also!offers!contract!research!services!in!enzyme!development!and!applications.!
Products:!
Amylases!
Amyloglucosidases!
Cellulases!
Catalase!
Lipases!(including!lipases!for!biocatalysis)!
Glucanases!
Hemicellulases!
Phytase!
Proteases!
Mannanase!
Xylanase!
Laccase!
Pectinase!
!
!
'
'
!
102!
!
!
!!
BASF'(Also'see'Verenium,'acquired'in'late'2013)'
www.basf.com!!
Carl:Bosch:Strasse!38!
67056!Ludwigshafen!
Germany!
Telephone:!+49!(0)621!60:0!
Fax:!+49!(0)621!60:42525!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1865!
110,000!employees!
Public!
Very!small!as!percentage!of!total!chemical!sales,!but!aggressively!growing.!
Detergents,!animal!feed,!proteases,!likely!cellulases!pending,!textile!and!oil!
field!enzymes.!
Many,!including!Dyadic’s!C1!platform!
Nearly!unlimited!
Kurt!Bock,!Chairman!of!the!Board!of!Executive!Directors;!Kai!Baldenius,!Head!
of!Biocatalysis!
BASF!scientists!are!involved!in!numerous!alliances!with!leading!universities,!
research!institutes,!startups,!industry!partners,!and!customers,!more!than!
1300!of!which!are!based!in!Europe.!
Global!
+++!!
++!(growing,!and!produced!on!large!scale)!Acquisition!of!Verenium!will!
expand!the!list!of!industrial!enzymes!
:!
BASF!is!the!world’s!largest!chemical!company,!and!the!company!produces!and!sells!chemicals,!plastics,!
performance!products,!agricultural!products,!enzymes,!and!fine!chemicals.!!!The!company!has!recently!
been!pushing!aggressively!into!the!use,!manufacture,!and!sale!of!enzymes.!!!
In!May!2013,!BASF!announced!a!partnership!with!Dyadic!to!use!the!Dyadic!C1!expression!and!
production!platform!to!manufacture!industrial!enzymes,!and!this!partnership!also!gives!BASF!access!to!
cellulases.!!BASF!is!collaborating!with!Direvo!to!develop!a!protease!for!pig!and!poultry!feed!applications.!!!
BASF!also!purchased!Henkel’s!detergent!enzymes!business!in!2013.!!!
!
103!
!
!
!!
Continuing!its!aggressive!expansion!into!enzyme!markets,!in!September!of!2013!BASF!announced!that!it!
is!acquiring!San!Diego,!California:based!Verenium,!which!will!give!it!immediate!access!to!new!enzyme!
products!and!market!channels!including!amylases,!phytases,!cellulases,!and!xylanase.!!The!acquisition!of!
Verenium!in!late!2013!will!also!add!a!US!location,!research!in!enzyme!evolution,!and!manufacturing!
capabilities.!See!the!entry!for!Verenium!for!additional!information.!
Enzyme!Products:!
Cellulase!
Protease!
Amylases!
Phytase!
Lipase!for!biocatalysis!applications!
Ketoreductases!for!biocatalysis!applications!
!
See!entry!for!Verenium,!page!400:401,!for!additional!enzymes!now!produced!and!offered!by!BASF.!
'
'
!
104!
!
!
!!
BBI'Enzymes'
http://www.bbienzymes.com!!
73!Ty!Glas!Avenue!
Cardiff,!CF14!5DX!!
UK!
Tel!(UK):!08444!176393!
Tel!(USA):!+1:800:423:8199!
Tel!(International):!+44!(0)!2920!747!232!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
450!employees!(parent!company)!
Private.!!BBI!enzymes!is!part!of!BBI!solutions,!which!is!in!turn!a!company!
within!the!BBI!group.!
Small!
Diagnostics!
Multiple!sources,!mainly!isolation!from!natural!organisms,!but!some!
recombinant!production!as!well.!
Up!to!700!Kg!batches.!!In:house!production.!
NA!
NA!
Global!
+++!(estimated!to!be!profitable)!
+++!(50+!enzymes)!
:!
From!the!company!website:!“BBI!Enzymes!is!a!manufacturer!of!enzymes!for!diagnostic!and!
pharmaceutical!applications.!Manufacturing!sites!Blaenavon,!Wales!(formerly!Biozyme)!and!Cape!Town,!
S!Africa!(formerly!Seravac).!Key!products!include!Glucose!Oxidase,!Horse!Radish!Peroxidase,!Alkaline!
Phosphatase,!Trypsin/Chymotrypsin!and!Hyaluronidase.!
BBI!Solutions!manufacture!a!diverse!range!of!enzymes!derived!from!microbial,!animal!and!plant!tissues,!
including!our!market!leading!glucose!oxidase!and!horseradish!peroxidase.!These!are!manufactured!in!
our!purpose!built!laboratories!in!the!UK!and!South!Africa,!enabling!us!to!provide!you!with!economical!
!
105!
!
!
!!
batch!sizes!of!up!to!700!kg.!BBI!Solutions!enzymes!are!ideal!for!a!variety!of!applications!including!clinical!
chemistry,!biosensor!manufacture!and!ELISA!assay.!
BBI!Solutions!products!are!not!intended!for!use!in!pharmaceutical!applications!and!does!not!offer!active!
pharmaceutical!ingredients!for!sale!in!the!USA.”!
Products:!
Acylase!
Alanine!transaminase!
Alkaline!phosphatase!
Alpha:amylase!
Ascorbate!oxidase!
Aspartate!aminotransferase!
Beta:glucuronidase!
Butyrylcholine!esterase!
Catalase!
Cathepsin!G!
Chymotrypsin!
Chymotrypsinogen!
Creatine!kinase!
Creatinine!amidohydrolase!
Creatinine!deiminase!
Cytochrome!C!
Deoxyribonuclease!
Elastase!
!
106!
!
!
!!
Gamma:glutamyl!transaminase!
Glucose!oxidase!
Glycerol!kinase!
Glycerophosphate!oxidase!
Hexokinase!
Hyaluronidase!
Lipoprotein!lipase!
Lipoxidase!
Lysozyme!
Mucopolysaccharidase!
Mutarotase!
Pepsinogen!
Peroxidase!
Phosphoenolpyruvate!carboxylase!
Ribonuclease!
Sarcosine!oxidase!
Trypsin!
Uricase!
Urease!
!
107!
!
!
!!
Xanthine!oxidase!
!
'
'
!
108!
!
!
!!
BehnMeyer'
www.behnmeyer.com!!
Ballindamm!1!
20095!Hamburg!
Germany!
Tel:!+49!40!30299!0!
Fax:!+49!40!30299!319!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1840!
950!employees!
Private!
Small!
Animal!nutrition!
Trichoderma,,Bacillus,
Christian!Traxel,!Hoh!Sooi!Kim,!Christa!Lorenz:Meyer,!Supervisors!
NA!
Global!
++!
+!
:!
Behn!Meyer!is!a!conglomerate!including!business!interests!in!paper!and!board,!agriculture,!ingredients,!
performance!chemicals,!and!polymers.!!!
Products:!
Phytase!
Carbohydrate!hydrolases!
!
!
!
'
'
!
109!
!
!
!!
BELDEM'(A'Puratos'Group'Company)'
http://www.beldem.com/!!
Industrialaan!25:28!
Zone!Maalbeek!
1702!GROOT!BIJGAARDEN!
Belgium!
Tel:!+!32!2!481!44!44!
Fax:!+!32!2!466!25!81!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1975!
Large!company!
Private,!part!of!the!Puratos!Group!
Enzymes!are!a!part!of!overall!product!mix!of!emulsifiers,!yeasts,!sourdoughs,!
yeast!extracts,!and!enzymes.!
Animal!feed!&!pet!food,!baking!industry,!beverages!industry,!milling!industry.!!!
Aspergillus,,Bacillus.!
Bulk.!!In:house!production.!!!
NA!
NA!
Global!
+++!
++!
:!
From!the!company!website:!“Beldem!is!integrated!in!the!new!PURATOS!Group!organization!as!a!part!of!
the!Strategic!Business!Unit!Bakery!and!has!been!divided!into!3!Business!Units!:!B.U.!Enzymes,!B.U.!
Emulsifiers!and!B.U.!Bioflavours!&!Yeast.”!
Products:!
Xylanases!
Alpha:amylases!
Pectinases!
Beta:glucanase'
!
!
110!
!
!
!!
Berg'+'Schmidt'GmbH'&'Co.'KG'
An!der!Alster!81!!
20099!Hamburg!!
Germany!
Tel:!+49!(0)!40/284!039:0!!
Fax:!+49!(0)!40/284!039:33!!
Email:!info@berg:schmidt.de!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Founded!more!than!50!years!ago.!
Owned!by!parent!company!the!Stern:Wywiol!Gruppe!
Significant!revenue!source,!likely!a!minority!portion.!
Animal!nutrition.!
NA!
Andreas!Reith,!Torsten!Wywiol,!Volkmar!Wywiol:!Managing!Directors!
Enzymes!are!made!by!other!companies!within!the!Stern:Wywiol!Group.!
Global!
NA!
+!
:!
Berg!+!Schmidt!is!a!supplier!of!both!specialty!fat!powders!and!enzyme!formulations!for!animal!nutrition.!!
The!fats!are!refined!products!of!palm!oil.!!!
Products:!
The!company!sells!enzyme!formulations!under!the!trade!name!Bergazyme!that!include:!
Pentosanases!(probably!xylanases)!
Glucanases!
!
'
'
!
111!
!
!
!!
Begerow'
www.begerow.com!!
Branch!Langenlonsheim!
An!den!Nahewiesen!24!
55450!Langenlonsheim!
Germany!
Tel:!+49!6704!204:0!
Fax:!+49!6704!204:121!
Email:!info:[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
270!
Owned!by!public!company!Eaton!(Ticker:!ETN)!
Small!
Fruit!juice,!beverage,!winemaking.!
Aspergillus,,extraction!from!animal!tissue,
Hans:Jakob!Vogt,!Anton!Mandt,!Managing!Directors!
NA!
Global!
+++!
++!
:!
From!the!company!website:!“We!are!the!specialists!for!liquid!filtration!processes!in!the!beverage!and!
food!industry!as!well!as!in!the!chemical,!pharmaceutical!and!industrial!sector.”!
Products:!
Pectinases,!Beta:glucosidases,!Beta:glucanases,!Lysozyme,!Amylases,!Amyloglucosidase!
!
!
'
!
112!
!
!
!!
BERLIN'TEXTILE'CHEMICALS'(ZHONGSHAN)'CO.,'LTD'
South!Area,!Jinxi!Village!
Zhongshan!City,!Guangdong!Province,!528455!
China!
Tel:!+86:760:88899180!!
Fax:!+86:760:88899280!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1982!
NA!
Private!
Small!
Textiles!
NA!
NA!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“We!have!been!supplying!a!wide!range!of!products!to!the!textile!dyeing,!
printing,!washing,!finishing!and!non!woven!industry!since!1982.!Besides!formulating!our!own!products,!
we!are!also!representing!a!number!of!world!renowned!chemical!manufacturers!as!agents!or!distributors!
in!Asia!and!mainland!China.!While!our!headquarters!is!in!Hong!Kong!,!we!set!up!Berlin!Textile!Chemicals!
(Zhongshan)!Company!Limited!in!1999,!introducing!advanced!technology!into!the!production!of!dyeing!
and!printing!auxiliaries,!and!special!printing!paste!series!as!well.!In!order!to!meet!customers'!demand,!
we!have!established!our!own!Research!&!Development,!laboratory,!customer!service,!formulation!
facilities!and!delivery!team.”!
Products:!
Cellulases!
!
!
113!
!
!
!!
BiCT'srl'
http://www.bict.it/!!
P.Iva!e!Cf!01274450194!!
Parco!Tecnologico!Padano,!Via!Einstein!SNC!loc.!Cascina!Codazza!!
26900!Lodi!(LO)!
Italy!
Tel:!+39!0371!4662452!
Tel:!+39!0371!4662523!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
11:50!
Private!
LIkely!small!
Immobilized!enzymes;!beta:Galactosidase,!Acylase,!Proteases,!Lipases!
E.,coli,,Saccharomyces,cerevisiae,,Kluyveromyces,lactis,and,Pichia,pastoris,
Small!scale!manufacture,!mg!scale.!
Roberto!Verga,!CEO!and!Business!Development!Manager!
Works!with!Resindion!for!enzyme!immobilization.!!BiCT!takes!part!in!several!
European!grants,!for!example!the!INNOVAZYME!2012!and!Kyrobio!grants.!
NA!
NA!
+!(small!catalog)!
+!(at!small!scale)!
From!the!company!website:!“BiCT!is!a!company!focused!on!the!research!and!production!of!bio:
molecules!such!as!enzymes!and!secondary!metabolites,!obtained!either!from!natural!source!(plant,!
animal!and!micro!organism)!and!through!recombinant!DNA!techniques.!!BiCT!expertise!ranges!from!
molecular!biology!until!heterologous!expression,!purification!and!immobilization!of!biocatalysts!for!
selective!biotransformation.!!The!main!company!goal!is!to!provide!very!cost:effective!and!industrial!
scale!biocatalyst!and!bioprocesses,!tailoring!them!on!a!client!specific!basis,!thanks!to!our!tight!
cooperation!with!Resindion,!a!subsidiary!of!Mitsubishi!Chemical!Corporation!producing!chromatography!
resins!and!enzyme!carriers.!!The!R&D!in!molecular!biology!and!protein!expression!is!actually!focused!on!
GRAS!(Generally!Regarded!As!Safe)!micro:organisms,!such!as!conventional!and!unconventional!yeasts.!!
!
114!
!
!
!!
The!BiCT!technology!on!biocatalysis!is!currently!applied!in!several!processes!in!different!fields!(from!
food!to!pharma,!from!nutraceutics!to!cosmetics).”!
Products:!
Immobilized!enzymes!
Beta:Galactosidase!
Acylase!
Proteases!
Lipases!
!
'
'
!
115!
!
!
!!
BIOBCAT'
www.bio:cat.com!!
9117!Three!Notch!Road!
Troy,!VA!22974!!
USA!
Tel:!+1:877:912:4622!!
Tel:!+1:434:589:4777!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
1988!
50!employees!
Private!
Enzymes,!enzyme!testing!and!blending!services,!and!microbe!formulations!
make!up!all!revenues.!
Food,!beverage,!baking,!animal!nutrition,!detergents,!textiles,!cleaning.!!!
Bacillus,,Aspergillus,,Trichoderma,,Chaetomium,,Rhizopus,,Carica,,Candida.!
Multi:ton!blending.!!No!in:house!production.!
Edward!Schuler,!CEO!and!Founder!
Distributor!for!Amano!Enzyme!and!Shin!Nihon!Chemical.!
NA!
+++!(growing!and!profitable)!
++!
:!(Bio:Cat!does!custom!blending!and!is!the!largest!enzyme!custom!blender!in!
the!USA)!
!
Bio:Cat!is!a!manufacturer,!blender,!and!supplier!of!enzyme!formulations.!!!The!company!also!custom!
blends!and!tests!enzyme!products!as!a!service,!and!additionally!supplies!microbial!cultures.!!It!is!unclear!
how!much!fermentative!enzyme!production!expertise!the!company!has,!if!any.!!The!company!purchases!
many!of!its!enzymes!from!leading!enzyme!bulk!suppliers!and!does!the!blending!and!formulating!in!
house.!!!
Products:!!
Proteases!
Amyloglucosidase!
Beta:glucanase!
!
116!
!
!
!!
Bromelain!
Catalase!
Cellulases!
Dextranase!
Amylases!
Lactase!
Hemicellulase!
Invertase!
Lipase!
Papain!
Pectinase!
Peptidase!
Phytase!
Xylanase!
Glucose!oxidase!
!
'
'
!
117!
!
!
!!
BiocatCollection'
http://www.biocatcollection.net/!!
Harburger!Schloßstraße!6:12!
D:21079!Hamburg!
Germany!
Tel:!+49:40:42878:4368!
Fax:!+49:40:42878:2729!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
ca.!2007!
1:10!employees!
BiocatCollection!is!set!up!by!TuTech!Innovation!GmbH,!a!private!company.!
100%!
Biocatalysis!
!
Lab!scale!
Helmut!Thamer,!CEO;!Garabed!Antranikian,!President!and!CSO!
The!BiocatCollection!was!initiated!by!the!Deutsche!Bundesstiftung!Umwelt!
(German!Environmental!Foundation,!www.dbu.de).!
Global!
NA!
++!
:!
The!BiocatCollection!is!a!spin:off!of!the!InnovationCentre!for!Biocatalysis!at!the!Hamburg!University!of!
Technology,!Germany.!!Its!mission!is!to!bring!enzymes!discovered!in!academia!to!become!widely!
available!for!reasonable!prices.!!Academic!and!other!institutions!can!submit!their!enzymes!to!
BiocatCollection!for!purchase!by!others.!!BiocatCollection!in!this!regard!is!an!enzyme!broker.!!There!are!
about!300!enzymes!in!the!company’s!collection,!and!they!are!available!in!small!quantities!at!relatively!
low!prices.!!!
Products:!
Lipases!
Esterases!
!
118!
!
!
!!
Cellulases!
Amylases!
Pullulanases!
Sugar!modifying!enzymes!
Proteases!
Nitrile!hydratases!
Nitrilases!
Amidases!
Alcohol!dehydrogenases!
Aldolases!!
Kinases!
Carbonic!anhydrases!
Unique!enzymes,!e.g.!an!amylomaltase!and!a!branching!enzyme.!!!
Many!of!the!above!enzymes!are!‘extremozymes,’!active!in!a!broad!temperature!and!pH.!!!
!
!
!
!
119!
!
!
!!
!
Biocatalysts'Limited'
http://www.biocatalysts.com!!!
Cefn!Coed!
Parc!Nantgarw!
CF15!7QQ!
Wales!
UK!
Tel:!+44!(0)!1443!843!712!
Fax:!+44!(0)!1443!846!500!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1986!
51:100!
Private!
Enzyme!sales,!enzyme:derived!product!sales,!and!contract!R+D!all!generate!
revenue.!
Food,!dairy,!baking,!and!beverage.!!!
Probably!many!
Multi:kilogram,!750!L!fermentor.!!In:house!production.!
Stuart!West,!Managing!Director;!Andrew!Ellis,!New!Product!Development!
Manager!
Many!partnerships!globally.!!Sales!office!in!the!USA.!
Many!globally.!
++!(reports!20%!growth!annually)!
+++!
+++!
Biocatalysts!Ltd!is!both!a!provider!of!a!range!of!off!the!shelf!enzymes!and!a!CRO/CMO.!!The!contract!
service!business!has!grown!steadily!and!the!company!has!had!many!partners!and!customers!over!the!
years.!!The!catalog!of!enzymes!is!substantial.!Recombinant!capabilities!include!host!strains!E.,coli!and!
Bacillus.!Company!has!worked!on!a!variety!of!other!enzymes!on!a!contract!basis,!including!many!
applicable!to!pharmaceutical!biocatalysis.!
!
!
120!
!
!
!!
Products:!
Muramylodextrinase!
Phenylalanine!dehydrogenase!
Glucanase!
Amylases!
Catalase!
Pepsin!
Mannitol!dehydrogenase!
Pectinase!
Tannase!
Trypsin!
Proteases!
Lipases!
Esterases!
!
'
'
!
121!
!
!
!!
Biochem'Zusatzstoffe'HandelsB'und'Produktionsgesellschaft'mbH'
www.biochem.net!!
Küstermeyerstraße!16!!
49393!Lohne!
Germany!
Tel:!+49!4442!92890!
Fax:!+49!4442!928928!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1986!
NA!
Private!
Minority!revenue!stream!
Animal!feed!
NA!
NA!
Sister!companies!in!France,!Russia,!Ukraine,!Egypt,!Poland,!Serbia,!Romania,!
Iran!and!Turkey!serve!further!regions!within!and!outside!Europe.!!Suppliers!
include!DuPont!and!AB!Enzymes.!
Europe,!Middle!East.!
NA!
+!
:!
Biochem!is!a!distributor!of!animal!feed!additives.!
Products:!
Phytase!
Amylases!
Xylanases!
Proteases!
!
!
!
122!
!
!
!!
Biomin'
http://www.biomin.net/!!
Industriestrasse!21!
3130!Herzogenburg!
Austria!
Tel.:!+43!2782!803!0!
Fax:!+43!2782!803!11308!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1983!
Large!
Private!
Relatively!small!but!important!portion!
Animal!feed!enzyme!phytase.!!FUMzyme,!a!unique!enzyme!that!degrades!
toxic!fungal!derived!fumonisins!in!animal!feed.!
NA!
NA!
NA!
Global.!
+++!
+!
:!
Biomin!is!an!animal!nutrition!company.!
Products:!
Phytase!
FUMzyme,!an!esterase!that!hydrolyzes!fumonisins!
!
'
'
!
123!
!
!
!!
BIOBPORT'Europe's.r.o.'
www.bio:port.cz!!!
Svinaře!98!
267!28!Svinaře!!
Czech!Republic!
Tel:!+420!272!659!617!!!!!!!
Fax:!+420!296!150!761!
Email:!obchod@bio:port.cz!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
Small!
Private!
Small!
Life!science!enzymes!
NA!
No!in:house!production.!!Laboratory:scale!quantitites.!
NA!
Many.!!Sells!NZYTech!enzymes!
NA!
NA!
+!
:!
BioPort!is!a!supplier!of!life!science!products.!!!
Products!from!NZYTech:!
Analytical!enzymes:!acetyl:CoA!syntethase,!D:alanine!aminotransferase!alcohol!dehydrogenase,!
aldehyde!reductase,!arginase,!aspartate!aminotransferase,!citrate!synthase,!glucokinase,!glucose:6:
phosphate!dehydrogenase,!glucose:6:phosphate!isomerase,!glutamate!dehydrogenase,!glutaminase,!
!
124!
!
!
!!
lactadehyde!dehydrogenase,!D:lactate!dehydrogenase,!D:malate!dehydrogenase,!L:malate!
dehydrogenase,!NADH!peroxidase,!sulfite!oxidase.!
!
'
'
!
125!
!
!
!!
BioPox'
http://www.biopox.com!!
Salita!Arenella,!9!80129!Naples!
Italy!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2011!
1:10!employees!
Private!
NA!
Pulp!and!paper,!textiles,!biofuels,!waste!water!treatment,!drug!manufacture,!
biosensors.!
NA!
Small!
Alessandra!Piscitelli!
NA!
NA!
Startup,!likely!unprofitable!currently.!
+!(about!5!listed!laccases)!
+!(service:based!small!scale!operation)!
BioPox!was!founded!to!commercialize!laccase!enzymes.!!They!intend!to!engineer!laccases!using!directed!
evolution!for!a!broad!range!of!enzymes!including!pulp!and!paper,!textiles,!effluent!treatment,!biofuels,!
biosensors,!drug!manufacture,!etc.!!BioPox!also!offers!protein!expression!services!to!generate!revenue.!!!
Key!Enzyme!Products:!
Laccases!
!
'
'
!
126!
!
!
!!
'Biorbyt'Ltd.'
www.biorbyt.com!!
5!Orwell!Furlong!
Cowley!Road!
Cambridge!
Cambridgeshire!
CB4!0WY!
UK!
Tel:!+44!(0)1223!859!353!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
!Fax:!+44(0)1223!280!240!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2010!
11:50!employees!
Private!
Very!small!
Life!science!and!molecular!biology!
None!
Laboratory!scale.!!No!in:house!production.!
NA!
Global!distributors!
Global!
NA!
++!
:!
Biorbyt!is!a!supplier!of!an!extensive!catalog!of!laboratory!reagents.!
Products:!
More!than!200!enzyme!offerings!including!restriction!enzymes!and!other!enzymes!for!DNA!and!RNA!
manipulation,!diagnostic!enzymes,!and!life!science!enzymes.!
!
!
!
127!
!
!
!!
BioResearch'Products'
http://www.bio:researchprod.com/!!
323!West!Cherry!Street!
North!Liberty,!IA!52317!
USA!
Tel:!+1:800:326:3511!
Tel:!+1:319:626:2423!
Fax:!+1:319:626:2240!
Email:!pbaehr@bio:researchprod.com;!bio@bio:researchprod.com!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1975!
About!25!employees,!about!$4!million!annual!revenues!
Subsidiary!of!IBEX!since!2013!
Revenues!comprised!of!enzyme!sales!and!custom!manufacturing!
Diagnostics,!biocatalysis,!industrial!applications!
Caldariomyces,fumago!wild:type!and!plant!sources.!
In:house!capacity!for!!40!L!and!300!L!fermentations,!scale!up!to!1000!L!at!the!!
Biocatalysis!and!Bioprocessing!Center!of!the!University!of!Iowa!
Paul!Baehr,!President!and!CEO!
NA!
NA!
+!
++!
++!
BioResearch!Products!was!acquired!by!IBEX!Technologies,!Inc.!(www.IBEX.ca)!in!on!December!31,!2012,!
and!now!operates!as!a!wholly:owned!subsidiary.!As!of!October!2013,!the!North!Liberty,!Iowa!site!is!still!
in!operation.!
From!the!website:!“Founded!in!1975,!Bio:Research!Products,!Inc.!(BRP)!specializes!in!manufacture!of!
enzymes!for!biomedical!manufacturing!and!research.!Recognized!as!the!worlds!leading!producer!of!
wheat!germ!phosphoenolpyruvate!carboxylase!(PEPC),!BRP!provides!the!following!services:!Protein!
purification,!characterization!and!analysis,!diagnostic!reagent!components,!custom!enzyme!production,!
contract!manufacturing!of!raw!material!enzymes!for!diagnostics,!pharmaceutical!and!industrial!
applications.”!
!
128!
!
!
!!
!
Products:!
Chloroperoxidase!
Immobilized!chloroperoxidase!
Soybean!peroxidase!
Immobilized!soybean!peroxidase!
Wheat:germ!phosphoenolpyruvate!carboxylase!
Maize!phosphoenolpyruvate!carboxylase!
Glutathione!reductase!
Diamine!oxidase!
!
!
'
'
!
129!
!
!
!!
Bioron'GmbH'
http://www.bioron.net/!!
Rheinhorststr.!18!
67071!Ludwigshafen!
Germany!
Tel:!+49!621!5720!915!
Fax:!+49!621!5720!916!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
20:50!employees!
Private!
Substantial!portion!
Molecular!biology!
E.,coli,
Lab!scale!
Sergei!Kovalenko,!Managing!Director!(CEO)!
NA!
Multiple!countries,!Germany!and!the!Middle!East!
NA!
+!
:!
Bioron!supplies!molecular!biology!tools!and!enzymes!for!research!use.!!!
Products:!
Proteinase!K!
T4!Ligase,!T4!RNA!Ligase,!T4!Polynucleotide!kinase!!
DNA!polymerase!
Exonuclease!III!
Inorganic!pyrophosphatase!
Uracil:DNA!glycosylase!(UDG)!
!
130!
!
!
!!
Bioseutica'Group'
www.bioseutica.com!!
!
Bioseutica!B.V.!!!
Landbouwweg!83!
3899!BD!Zeewolde!
The!Netherlands!!!
Tel:!+31.36.522.6300!!!
Fax:!+31.36.522.6833!
!
Neova!Technologies!Inc.!!!
31212!Peardonville!Road!
Abbotsford!BC!V2T!6K8!!!
Canada!!
Tel:!+1.604.504.0695!!!
Fax:!+1.604.859:2679!!
Email:[email protected]!!!
!
FORDRAS!SA!!!
Corso!Elvezia!4!
6900!Lugano!
Switzerland!!!
Tel:!+41.091.972.5005!!!
Fax:!+41.091.972.9411!
!
131!
!
!
!!
!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1947!
201:500!employees!
Private!
Major!portion!of!revenues!
Dairy,!animal!and!human!health,!winemaking!and!brewing!
All!enzymes!are!extracted!from!animal!tissue!
Bulk!
Henk!Altena,!Financial!Controller!
Company!is!comprised!of!three!businesses:!Bioseutica!(Netherlands),!Fordras!
SA!(Switzerland),!and!Neova!Technologies!(Canada)!
Global!
NA!
+!
:!
From!the!website:!“Bioseutica!is!an!integrated,!specialty!pharmaceutical!group!dedicated!to!the!
development!of!the!highest!quality!products,!using!natural,!renewable!sources!for!the!healthcare,!food!
and!feed!industries.!!Bioseutica!focuses!on!the!global!supply!of!the!highest!quality!bioactive!proteins,!
including!egg!derived!proteins,!such!as!egg!lysozyme,!avidin!or!ovotransferrin!and!pancreatic!enzymes.!
Bioseutica’s!manufacturing!processes!are!built!on!high:end,!cutting:edge!proprietary!technology!and!
allow!us!to!produce!ingredients!of!highest!purities!in!our!manufacturing!facilities!in!Canada!and!
Europe.”!
Products:!
Lysozyme!
Trypsin!
Phospholipase!
!
!
!
!
!
'
'
!
132!
!
!
!!
Biosphere'
http://www.biospheresrl.com/!!
Via!Cellaimo!3532!Bertinoro!(Forlì:Cesena)!
Italia!47032!!
Italy!
Tel:!+39.0543444597!!
Fax:!+39.0543444600!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
1:10!employees!
Private!
Biocatalysis!
Burkholderia,cepacia,,Aspergillus,,Pseudomonas,fluorescens,,Candida,rugosa,,
Candida,antarctica,,Kluyveromyces,lactis,,Bacillus,megaterium,,Escherichia,
coli,,Bacillus,licheniformis,,Saccharomyces,cerevisiae,,Pichia,pastoris,,
Hansenula,polymorpha,
Fermenters!up!to!1500!L!
Marco!Pistocchi,!Chief!Operating!Officer;!Arianna!Andreotti,!Business!
Development!Manager!
BiCT,!Actygea,!BioPox!
NA!
NA!
++!(medium!sized!selection,!all!immobilized)!
++!!
From!the!company!website:!“With!more!than!ten!years!of!hands:on!experience!in!pharmaceutical,!
cosmetic!and!food!biotech!industry,!our!scientists!and!technical!staff!developed!skills!ranging!from!
microbial!fermentation!process!development,!to!process!scale!up!and!recovery!of!products.!Biosphere!
provides!a!qualified!contract!manufacturing!service!for!the!production!of!microbial!biomass,!enzymes!
and!metabolites.!Our!laboratories,!pilot!plants!and!production!facilities!are!designed!to!work!with!
microorganisms!up!to!bio!safety!level!2!and!GMOs.!Biosphere!collaborates!with!companies,!universities,!
research!institutes!and!scientific!networks!in!several!research!projects,!with!private!or!public!funding.!
The!contract!R&D!service!is!mainly!addressed!to:!!the!study!of!new!enzymes!for!the!Pharmaceutical!
sector;!the!improvement!and!innovation!of!traditional!products!and!valorisation!of!by:products!in!the!
!
133!
!
!
!!
Food!and!Feed!sectors;!the!development!of!active!substances!from!microbial!source!for!the!cosmetic!
industry.!Biosphere!was!founded!in!1999!as!the!biotechnology!division!and!R&D!center!of!SFIR!Group,!a!
leading!Italian!player!in!the!sugar!industry.!In!2002!Biosphere!became!an!independent!company!after!
the!development!of!new!projects!and!the!start!of!the!production!activities.!In!2012!Orogel!SpA,!Softer!
SpA!and!Ayrion!Sustech!SpA!became!new!shareholders!of!the!company,!together!with!SFIR!SpA.”!
Products:!
Immobilized!enzymes!
Lipases:!7!enzymes!
Beta:galactosidases!(2!enzymes)!
Amidases!(2!enzymes)!
Subtilisin!
'
'
'
!
134!
!
!
!!
Biovet'
http://www.biovet.com/!!
3а!Nikolay!Haytov!Str.!
1113!Sofia!
Bulgaria!
Tel:!+!359!2!862!53!ext.!30,!31,!36!
Tel:!+!359!2!868!2095!
Fax:!+!359!2!862!5334!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1961!
Over!1000!employees!
Public:!53b!(SOFIX)!
Important!minority!contributor!to!revenues!
Animal!feed,!human!health.!!!
Trichoderma,longibrachiatum,!others!not!disclosed!
Multi:ton.!In:house!production!likely.!
Kiril!Domuschiev,!President!
NA!
Global.!!50%!of!sales!in!European!Union!
+++!
++!
:!
From!the!company!website:!“BIOVET!is!a!leading!European!manufacturer!and!marketer!of!medicated!
and!nutritional!feed!additives,!enzymes,!bulk!active!substances!and!pharmaceuticals!for!farm!animal!
productivity!and!animal!health.!The!company!offers!intermediates,!active!ingredients!and!medicines!for!
the!human!pharmaceuticals!industry.!We!provide!enzymes,!enzyme!complexes!and!other!ingredients!for!
the!baking,!brewing,!juice!production,!alcohol!production,!wine:making,!oil!extraction,!pharmaceuticals,!
paper,!detergents,!leather!and!textiles!industries.”!!
Products:!
Endo:1,4:beta!glucanase!
Endo:1,3(4):ß:glucanase!
Pentosanase!
!
135!
!
!
!!
Hemicellulase!
α:Amylase!
Protease!
Xylanase!
Phytase!
!
!
!
'
'
!
136!
!
!
!!
Biozym'Scientific'GmbH'
www.biozym.com!!!
Steinbrinksweg!27!
31840!Hessisch!Oldendorf!
Germany!
Tel:!+49!(0)!51!52!/!90!20!
Fax:!+49!(0)!51!52!/!20!70!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2003!
NA!
Private!
Small!
Molecular!biology!enzymes.!
NA!
Lab!scale!
Hartmut!Groth,!President!
Finnzymes,!Enzymatics!
NA!
NA!
+!
:!
Biozym!Scientific!sells!life!science!tools!and!reagents.!!The!company!is!a!reseller/retailer!and!does!not!
carry!out!manufacturing!of!enzymes!in!house.!!!
Products:!
Ligases,!DNA!and!RNA!polymerases,!Reverse!transcriptase,!Nucleases,!Kinase!
Glycosylase!
Phosphatase!
'
'
!
137!
!
!
!!
Bio'Zyme'
www.biozyme.ro!!!
Strada!Zorilor,!nr.!40!ap.15!
400335!Cluj:Napoca!
Romania!
Tel:!+40!264!523!281!
Fax:!+40!264!523!281!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Small!
Life!science!enzymes.!
NA!
No!in:house!production.!!Supplies!laboratory:quantities.!
NA!
Many.!!Sells!NZYTech!enzymes.!
NA!
NA!
+!
:!
BioZyme!is!a!supplier!of!a!broad!range!of!life!science!products.!!!
!
138!
!
!
!!
!
!
'
'
!
139!
!
!
!!
BRAIN'AG!(Biotechnology!Research!And!Information!Network!AG)!
http://www.brain:biotech.de!!
Darmstädter!Straße!34:36!
64673!Zwingenberg!
Germany!!
Tel:!+49!(0)!62!51!/!9331:0!
Fax:!+49!(0)!62!51!/!9331:11!
Email:!public@brain:biotech.de!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1993!
105!employees!
Private!
Revenue!is!from!contract!R+D,!some!government!grants.!
NA!
Actinomyces,,E.,coli,,others!
Probably!pilot!scale,!up!to!a!few!hundred!L!fermentation.!
Holger!Zinke,!CEO!and!founder;!Jürgen!Eck,!CTO.!!!
Partnership!with!Enzymicals!for!biocatalysis!in!the!pharmaceutical!industry.!!
In!its!history,!BRAIN!has!more!than!80!collaborations/partnerships!with!
leading!companies!like!BASF,!Ciba,!Clariant,!DSM,!Evonik!Degussa,!Henkel,!
Nutrinova,!Sandoz,!Schering,!Südzucker!und!Symrise.!!BRAIN!purchased!the!
German!cosmetic!firm!LA!Schmitt,!giving!it!integration!of!the!development,!
production,!and!sale!of!cosmeticals.!Ownbs!an!equity!stake!in!German!
enzyme!developer!!Enzymicals!AG!(vide!infra).!
Contract!research!carried!out!for!mostly!European!companies:!BASF,!Ciba,!
Clariant,!DSM,!Evonik!Degussa,!Henkel,!Nutrinova,!Sandoz,!Schering,!
Südzucker!und!Symrise.!!
++!(well!funded)!
:!
+!(mostly!R+D)!
BRAIN!has!traditionally!focused!on!contract!research!services!rather!than!product!sales.!!The!company!
has!been!a!contract!research!organization!for!most!of!its!existence,!and!has!worked!with!many!well:
known!companies.!!In!November!2012,!the!company!raised!€60!million!from!the!Putsch!family!and!MIG!
Fonds.!!It!has!outlined!a!‘buy!and!build’!strategy!to!make!use!of!its!new!capital!infusion,!indicating!that!
more!acquisitions!will!be!initiated!by!BRAIN.!!BRAIN!has!extensive!libraries!of!microorganisms!and!
!
140!
!
!
!!
recombinantly!expressed!genes!from!culturable!and!unculturable!organisms.!!It!calls!its!platform!
EvoSolution®,!and!this!platform!encompasses!its!BioArchive!of!tens!of!thousands!of!microbial!strains!
and!its!Biodiversity!library.!!The!Biodiversity!library!consists!of!genes!from!culturable!and!unculturable!
organisms!expressed!as!large!insert!libraries,!LIL®.!!The!company!has!strong!robotics!and!screening!
capabilities.!!BRAIN!applies!its!technology!to!enzymes!and!biocatalysts,!to!designer!microorganisms,!and!
to!producing!bioactive!compounds.!!!
!
!
'
'
!
141!
!
!
!!
Brenntag'
www.brenntag.com!!
Stinnes:Platz!1!
D:45472!Mülheim/Ruhr!!
Germany!
Tel:!+49!(0)!208/7828:0!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1874!
13,000!employees!
Public.!!Ticker:!BNR!
Very!small!
Animal!nutrition!
None!
Steven!Holland,!CEO!
Distributes!enzymes!for!AB!Enzymes.!
Global!
+++!
+!
:!
From!the!press:!“Brenntag,!the!global!market!leader!in!chemical!distribution,!covers!with!its!extensive!
product!and!service!portfolio!all!major!markets.”!
Products:!
A!chemical!distributor!whose!distributed!products!include!enzymes.!Product!line!not!specified!on!web!
site,!but!distributes!for!AB!Enzymes.!!See!AB!Enzymes!entry!for!details!on!their!product!lines.!In!
September!2013!Brenntag!acquired!the!chemical!distribution!business!of!ZYtex!Group!in!India.!The!
biotechnology!and!food!ingredients!distribution!business!will!become!part!of!Brenntag!India,!
headquartered!in!Mumbai.!The!acquired!business!has!its!focus!on!enzymes!and!yeast!for!a!broad!
application!range!in!the!food!and!beverage!industries!in!India.!
!
'
'
!
142!
!
!
!!
B.S.C.'nv'
www.bscbio.be!!
Zwaarveld!41!!
9220!Hamme!
Belgium!
Tel:!+32!52!47.05.36!!
Fax:!+32!52!47.26.64!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1985!
Small!
Private!
Food,!feed,!beverage,!human!health.!
Extraction!from!papaya!(plant!tissue)!
Bulk!
NA!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“B.S.C.!is!deeply!committed!in!the!development,!formulation!and!marketing!
of!niche!market!biochemicals!based!on!natural!active!components!for!the!food–feed:beverage!and!
pharma!industry.”!
Products:!
Papain!
!
!
!
!
!
143!
!
!
!!
!
C.Schliessmann'
http://www.c:schliessmann.de/!!
Kellerei:Chemie!GmbH!&!Co.KG!
Auwiesenstrasse!5!
DE!:!74523!Schwäbisch!Hall!
Germany!
Tel:!+49:(0)791/97191:0!
Fax:!+49:(0)791/97191:25!
Email:!service@c:schliessmann.de!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1925!
Small!
Private,!family!owned!by!the!Heller!family!
Relatively!small!
Winemaking!and!distillation!alcohol!production!enzymes.!
None!
None!
Rudolf!Heller,!President!
Distributes!enzymes!from!WeissBiotech,!which!in!turn!are!manufactured!by!
Verenium.!
NA!
NA!
++!
:!
C.Schliessmann!is!a!provider!of!winemaking!and!distillation!alcohol!production!goods!including!yeasts,!
enzymes,!fermentation!additives,!analytical!services,!and!equipment.!!!
Products:!
Pectinases,!Amylases,!Proteases,!Xylanases,!Hemicellulases,!Beta:glucanase!
!
'
'
!
144!
!
!
!!
C5.6'Technologies'
http://c56technologies.com/!!
2905!Parmenter!Street!
Middleton,!WI!53562!
USA!
Tel:!+1:608:836:3587!
Fax:!+1:608:836:3626!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
4!employees!
Private!
Small!
34!cellulase!degrading!enzymes!sold!through!partner!Lucigen!
NA!
Small!
David!Mead,!CEO!and!Co:Founder!
Spun!out!of!Lucigen!
NA!
NA!
++!(unique!cellulase:degrading!enzymes)!
NA!
From!the!company!website:!“C5•6!Technologies!Inc.!creates!bio:based!solutions!to!efficiently!convert!
biomass!into!five!and!six!carbon!sugars.!The!company!is!developing!the!next!generation!of!enzyme!
solutions!that!are!up!to!50!fold!more!potent!than!competing!products.!As!part!of!its!enzyme!screening!
and!development!program!the!company!has!commercialized!34!new!enzyme!products!called!CAZyme™!
Carbohydrases!through!its!reagent!partner,!Lucigen!Corp.!Several!of!these!CAZymes!hold!promise!in!the!
therapeutic!industry!in!fighting!infectious!diseases.!C5•6és!microbial!and!enzyme!technology!platform!
has!been!developed!over!the!course!of!seven!years!using!US!Government!SBIR!grants!and!private!equity!
investments.!C5•6!is!an!industrial!partner!of!the!University!of!Wisconsin’s!Great!Lakes!Bioenergy!
Research!Center!funded!by!the!DOE.”!
Proucts:!
Cellulases!(34!enzymes)'
!
!
145!
!
!
!!
Calzyme'Laboratories,'Inc.!
http://www.calzyme.com/!!
3443!Miguelito!Court!
San!Luis!Obispo,!CA!93401!
USA!
Tel:!+1:805:541:5754!
Tel:!+1:800:523:9127!
Fax:!+1:805:541:8301!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Nearly!100%!
Many!for!research!and!diagnostic!use!
Derived!from!animal!and!plant!tissue,!non:recombinant!
Grams!to!kilograms.!!In:house!production.!!
Muzzafar!Iqbal,!PhD,!Founder!and!President;!Roger!Reapando,!Manager,!
Tuelake,!CA!site!
NA!
NA!
NA!
+++!
NA!
Calzyme’s!website!states!that!it!is!a!manufacturer!of!enzymes,!proteins,!coenzymes,!subtrates,!and!
related!biochemicals.!!An!online!catalog!with!a!large!product!range!is!listed!in!the!web!site.!The!
Company!also!is!a!primary!producer!of!horse!radish!peroxidase!from!California:grown!horse:radishes!
and!offers!bulk!quantities.!
Products:!
Calzyme!lists!about!100!enzymes!for!diagnostics!and!life!science!research!use.'
'
'
!
146!
!
!
!!
Cambrex'
http://www.cambrex.com/!!!
One!Meadowlands!Plaza !
East!Rutherford,!NJ!07073!!
USA!!
Tel:!+1:201:804:3000!
Tel:!+1:866:286:9133!!
Fax:!+1:201:804:9852!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1981!
950!employees!
Public:!CBM!
Small!
NA!
NA!
Pilot!scale!
Steven!M.!Klosk,!CEO!of!Cambrex;!Antje!Gupta,!Managing!Director!of!
Cambrex!IEP!subsidiary!in!Wiesbaden,!Germany!
NA!
Global!
+++!
NA!
+!
Cambrex!is!a!global!life!science!company!that!offers!products!and!services!for!pharmaceutical!research,!
development,!and!manufacture.!!It!has!operations!in!the!USA,!Sweden,!Italy,!and!Estonia.!!Cambrex!IEP!
is!a!subsidiary!that!focuses!on!engineering,!selling,!and!using!enzymes!as!biocatalysts!in!pharmaceutical!
manufacture.!!Though!it!does!not!sell!a!catalog!of!enzymes,!Cambrex!IEP!has!a!library!of!at!least!100!
enzymes!(transaminases!and!reductases,!potentially!others)!that!it!screens!as!a!service,!and!can!then!
provide!the!enzyme(s)!that!work!in!a!client’s!process!on!a!pilot!scale.!!
!
'
'
!
147!
!
!
!!
Cellectis'
http://www.cellectis.com/!!
Biopark!
8!rue!de!la!Croix!Jarry!
75013!Paris!!
France!
Tel:!+33!(0)1!81!69!16!00!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
220!employees!
Public!
Life!science!tools!for!DNA!manipulation.!
NA!
Lab!scale!
André!Choulika,!Chairman!and!CEO!
NA!
Global!
:!(additional!funding!needed!soon,!high!burn!rate)!
++!
:!
From!the!company!website:!“Cellectis!Group!is!a!worldwide!pioneer!and!leading!company!in!the!fields!
of!genome!engineering!and!cell:based!therapies.!Based!on!a!unique!intellectual!property!portfolio,!
Cellectis!has!developed!strong!expertise!in!technologies!enabling!precise!genome!modification!and!stem!
cells!with!applications!ranging!from!cancer!immuno:therapy,!gene!therapy!to!regenerative!medicine.!
The!Group!leads!collaborative!partnerships!with!pharmaceutical,!biotech!and!seed!companies.”!!
Products:!
Meganucleases!and!TALENs!(Transcription!activator:like!effector!nucleases),!and!kits!for!their!use.!
'
'
!
148!
!
!
!!
CENTERCHEM'
http://www.centerchem.com/!!
20!Glover!Avenue!
Norwalk,!CT!06850!
USA!
Tel:!+1:203:822:9800!
Fax:!+1:203:822:9820!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1948!
11:50!employees!
Private!
Small!portion!of!total!revenues.!!
Food!enzymes.!
NA!
NA!
NA!
Global!
NA!
+!(small!selection)!
:!
From!the!company!website:!“Centerchem!is!a!leading!international!supplier!and!marketer!of!quality!
functional!ingredients!used!in!a!wide!range!of!industries.!Since!1948,!we!have!built!a!network!of!
specialty!manufacturers!throughout!the!world,!as!well!as!unparalleled!internal!resources!including!a!
highly!specialized!technical!personnel,!a!thorough!knowledge!of!transportation!regulations,!and!
technical!market!research!and!promotional!expertise.!Together!with!the!numerous!technologies!to!
which!Centerchem!has!access,!our!unique!capabilities!allow!us!to!provide!our!partners!with!the!highest!
levels!of!support.!“!
Products:!
Invertase!
Pectinases!
Amylases!
!
!
149!
!
!
!!
Chematics,'Inc.'
http://www.chematics.com/!!
PO!Box!293!!
North!Webster,!IN!46555!
USA!
Tel:!+1:800:348:5174,!+1:574:834:2406!
Fax:!+1:574:834:7427!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
Small!
Private!
Though!enzymes!are!in!most!of!the!kits!that!Chematics!offers,!only!one!
enzyme!is!offered!on!its!own!and!makes!up!a!small!portion!of!revenues.!
Diagnostic!
Pichia,pastoris,
Kg!scale!
William!Woenker,!CEO!
Sells!alcohol!oxidase!through!Sigma:Aldrich!
NA!
NA!
+!!
:!
From!the!company!website:!“Chematics!is!a!privately!held!biotechnology!company!engaged!in!the!
development!and!manufacture!of!novel!in:vitro!diagnostic!testing!solutions!and!products!that!facilitate!
early!identification!of!abnormal!or!unhealthy!conditions.!Founded!in!1988,!Chematics!is!located!in!North!
Webster!Indiana.!Our!objective!as!a!company!is!to!provide!our!customers!worldwide!with!innovative!
easy!to!use!products,!at!a!reasonable!price!that!are!of!the!highest!quality!and!are!safe!and!effective!
when!used!for!the!purposes!for!which!they!are!intended.!Our!success!as!a!business!depends!upon!
achievement!of!this!objective!and!upon!continuous!improvement!of!our!products,!processes!and!
customer!experiences.”!
Products:!
Alcohol!Oxidase!
!
!
150!
!
!
!!
CHEMOS'GmbH'
http://www.chemos:group.com/!!
Werner:von:Siemens!Str.!3!
D:93128!Regenstauf!!
Germany!
Tel:!+49!9402!9336!0!
Fax:!+49!9402!9336!13!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
ca.!1988!
NA!
Private!
Likely!very!low!
A!random!selection!of!enzymes!from!outside!suppliers.!!!
None!
NA.!!No!in:house!production.!
Ulrike!Lingner:Hoffmann,!CEO!
CLEA!Technologies!supplies!some!of!the!enzyme!products.!
Europe!
NA!
+!
:!
From!the!company!website:!“CHEMOS!GmbH!is!a!solid!family:owned!enterprise!with!an!experience!of!
25!years:!Emerged!from!a!chemical!laboratory,!grown!and!evolved!into!a!trading!company.!!Providing!a!
special!service!in!trading,!we!do!not!synthesize!or!produce!any!goods.!Our!strength!lies!in!a!big!database!
and!a!grown!worldwide!network.!!CHEMOS!GmbH!manages!import!and!export!of!rare!raw!materials!and!
for!specially!synthesized!chemicals!that!are!difficult!to!procure.!!International!and!established!contacts!
with!traders!and!producers!characterize!our!work.!We!are!proud!of!the!appreciative!confidence!of!our!
long:term!costumers.!!CHEMOS!GmbH!is!a!specialty!trading!company!for!chemical!products!performing!
worldwide.!We!supply!the!goods!to!support!your!research,!development!and!production!flow.!!More!
than!180.000!articles!from!partners!from!all!over!the!world!are!ready!for!your!request.!!CHEMOS!GmbH!
does!not!pursue!warehousing!and!keeps!only!a!few!goods!in!stock.”!
!
!
151!
!
!
!!
Products:!
About!100!enzymes!including!
Lipases!
Glucose!oxidase!
Lactate!oxidase!
Ascorbate!oxidase!
Bilirubin!oxidase!
Chloroperoxidase!
Choline!oxidase!
Peroxidase!
DNA!ligase!
RNA!ligase!
!
!
!
152!
!
!
!!
Chimab!
www.chimab.it!!
via!Colombo,!34!
35011!Campodarsego!(PD)!!
Italy!
Tel:!+39!049!9201496!
Fax:!+39!049!9201498!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1985!
Medium!sized!company!
Private!
Small!
Food!processing.!
NA!
Bulk.!!In:house!production!unclear.!
Giorgio!Agostini,!owner!
NA!
Europe,!Russia.!
NA!
+!
:!
From!the!company!website:!“Chimab!has!been!a!partner!of!the!Italian!and!international!food!industries!
since!1985!through!the!supply!of!functional!food!ingredient!solutions,!distribution!of!ingredients!and!
production!of!functional!semi:finished!products!combined!with!consultancy!and!application!assistance!
services!dedicated!to!its!clients.”!
Products:!
Phospholipases!
Transglutaminase!
Baking!and!flour!enzymes.!
!
!
153!
!
!
!!
!
Chiral'Vision'
http://www.chiralvision.com/!!
J.H.!Oortweg!21!
2333!CH!Leiden!
The!Netherlands!
Tel:!+31!71!332!2124!
Tel:!+31!64!603!8991!!
Fax:!+31!71!332!2125!
Fax:!+31!84!758!7301!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
NA!
Private!
Large!portion!of!revenues!
Immobilized!versions!of!commercial!and!proprietary!enzymes,!including!in!kit!
format!of!wide!range!of!enzymes!for!biocatalysis!applications.!
None!
Sells!batches!of!up!to!10!Kg!
Dr.!Rob!Schoevaart,!CEO!
Purchases!enzymes!from!c:LEcta,!Novozymes,!Amano,!Meito,!Sigma,!DSM,!
etc.!
Global.!!Distributes!through!Ryan!Scientific,!Austin!Chemical!Company,!and!
Syncozymes.!
++!(profitable,!25%!annual!growth!rate)!
+++!(extensive!collection!of!biocatalysts!for!fine!chemical!processes)!
+!
Chrial!Vision!specializes!in!immobilizing!enzymes.!!The!company!sells!immobilized!enzymes!both!in!kit!
and!individual!form,!and!additionally!immobilizes!enzymes!for!customers!on!a!service!basis.!!The!
company!also!will!do!chemical!process!development!using!its!enzymes!as!a!service.!!Instead!of!
expressing!and!producing!its!own!enzymes,!Chiral!Vision!purchases!the!soluble!enzyme!products!of!
!
154!
!
!
!!
other!suppliers!and!does!the!immobilization!in!house.!!The!company!also!sells!chiral!intermediates!that!
it!makes!with!its!enzymes,!and!the!beads!that!it!uses!for!immobilization.!
Key!Enzyme!Products!(All!Immobilized!Versions):!
Aldolase!(DERA)!
Amidase!
D:amino!acid!dehydrogenase!
Cytochrome!P450!Monooxygenase!
Ene!reductase!
Epoxide!hydrolase!
Esterase!PLE!(microbial!pig!liver!esterase)!
Formate!Dehydrogenase!(FDH)!
Glucose!Dehydrogenase!(GDH)!
Ketoreductase!(KRED)!
D:Lactate!dehydrogenase!nicotinamide!
Leucine!dehydrogenase!
Lipase!
Nicotinamide!mononucleotide!adenylyltransferase!
NAD!Kinase!
Nitrilase!
Nitrile!hydratase!
Nitro!Reductase!
Oxynitrilase!!
Penicillin!G!amidase!
Phospholipase!
Protease!
ω:Transaminase!
!
!
155!
!
!
!!
!
Chr.'Hansen'
http://www.chr:hansen.com/!!
Bøge!Allé!10:12!
DK:2970!Hørsholm!
Denmark!
Tel:!+45!45!74!74!74!
Fax:!+45!45!74!88!88!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1874!
2,500!employees!
Public:!CHR!
Small!
Dairy!enzymes.!
Kluyveromycis,lactis,!other!fermentation!microbes,!and!extraction!from!egg!
whites!and!animal!tissue.!Non:recombinant!products!only.!
Multi:ton!
Cees!De!Jong,!CEO;!Knud!Vindfeldt,!Exec.!VP!Cultures!and!Enzymes!
Partnered!with!Novozymes!for!some!enzyme!projects,!Novo!owns!a!minority!
share!
Global!
+++!
++!
:!
Chr.!Hansen!is!an!ingredients!company!and!supplies!its!products!to!the!food,!beverage!(especially!dairy),!
and!animal!nutrition!industries.!!The!company!specializes!in!non:recombinant!enzymes!for!the!food!
industry.!
Products:!
Lactase,!Rennet,!Chymosin,!Lipases,!Lysozyme,!Phospholipase,!Novel!lactose:to:lactobionic!acid!enzyme!
!
'
'
!
156!
!
!
!!
CHT/BEZEMA'
http://www.cht:group.com/!!
CHT!R.!BEITLICH!GMBH!
Bismarckstr.!102!
72072!Tübingen!
Germany!
Tel:!+!49!(0)!7071/154!:!0!
Fax:!+!49!(0)!7071/154!:!290!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1953!
1,600!employees!
Private!family!owned!
Small!
Textile!treatment.!!!
NA!
Bernhard!Hettich,!Erich!Mechel,!Managing!Directors!
NA!
Global!
+++!
+!
:!
CHT/Bezema!is!a!conglomerate!of!many!companies!with!four!specific!divisions:!textiles,!textile!care,!
construction,!and!performance!chemicals.!!In!textiles,!the!company!offers!enzymes!for!desizing.!
Products:!
Amylases!
Pectinases!
Hemicellulases!
'
'
!
157!
!
!
!!
Clea'Technologies'BV!
www.cleatechnologies.com!!
Delftechpark!34!
2628!XH!Delft!
The!Netherlands!
Tel:!+31!(0)15!7600!300!
Fax:!+31!(0)15!7600!301!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
2002!
11:50!employees!
Private!
100%!of!revenues!from!immobilized!enzyme!sales,!custom!R+D,!and!
consulting.!
Immobilized!enzymes!created!by!the!CLEA!technique:!Cross:Linked!Enzyme!
Aggregates.!!!
NA!
Small!scale!
Roger!A.!Sheldon,!CEO!and!President!
NA!
CO2!Solutions!employed!the!services!of!CLEA!to!immobilize!carbonic!
anhydrase!enzymes.!
++!(estimated)!
++!
+!(Enzymes!worked!on!in!the!past!include!hydrolases,!penicillin!G!acylases,!
lipases,!esterases,!proteases,!nitrilases,!aminoacylase,!phytase,!
galactosidase,!carbonic!anhydrase,!oxidoreductases,!KREDs,!FDH,!glucose!
oxidase,!galactose!oxidase,!amino!acid!oxidase,!laccase,!catalase,!
chloroperoxidase,!HRP,!lyases,!nitrile!hydratases,!PDC,!DERA,!nitrile!
hydratase,!transferases,!and!transaminases.)!
!
CLEA!is!an!acronym!for!cross:linked!enzyme!aggregates,!which!are!the!product!that!the!company!offers.!!
The!company!offers!a!selection!of!immobilized!enzyme!products,!and!additionally!offers!custom!
immobilization!of!enzymes!and!contract!research!to!develop!biocatalytic!processes!using!immobilized!
enzymes.!!The!company!also!offers!a!selection!of!soluble!enzymes.!!!
!
!
158!
!
!
!!
Products:!
Lipases!(about!10!immobized!lipases!and!20!soluble!lipases)!
Proteases!(7!immobilized!proteases!and!about!10!soluble!proteases)!
Nitrile!hydratase!
Amidases!(soluble!and!immobilized)!
Hydroxyl!nitrilase!!!
!
!
!
159!
!
!
!!
!
cBLEcta'GmbH'
http://www.c:lecta.com/!!
Perlickstraße!5!
04103!Leipzig!
Germany!
Tel:!+49:341:3552140!
Fax:!+49:341:35521433!
Email:!contact@c:LEcta.com!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
About!50!employees!
Private!
Most!revenues!are!from!partnerships,!enzymes!are!a!minority!portion.!
Biocatalysis,!molecular!biology.!
Proprietary!strains!of!E.,coli,,Pichia,,and!Bacillus.!
Pilot!scale!
Marc!Struhalla,!Managing!Director!(CEO)!and!Co:Founder;!Dr.!Andreas!
Buthe,!Business!Development!Manager;!!
Current!and!past!partners!and!customers!include!Chiral!Vision,!AquaPharm,!
Clariant,!Sartorius!Stedim!Biotech,!Acoris!Research,!Symrise,!Henkel,!and!
Cognis.!!!
Global!
++!
++!
+!
c:LEcta’s!business!includes!both!offering!enzymes!for!sale!and!engaging!in!biocatalyst!development!
partnerships.!!The!company!has!formed!and!seeks!partnerships!with!other!companies!to!develop!
enzymes!for!a!wide!range!of!applications!including!fine!chemicals,!food!and!feed,!life!science!tools,!
textiles,!detergents,!biofuels,!and!green!chemicals.!!c:LEcta!has!collections!of!environmental!DNA!as!well!
as!5000!strains!of!microbes!that!serve!as!a!starting!point!for!its!research!efforts.!!Using!its!Cluster!
Screening!technique,!it!can!evaluate!in!excess!of!a!million!samples!per!day!in!high:throughput!format.!!
Further!development!of!promising!enzymes!is!done!by!directed!evolution!and!expression!development.!!
!
160!
!
!
!!
The!company!has!done!strain!engineering!for!efficient!enzyme!production!using!proprietary!strains!of!E.,
coli,,Pichia,,and!Bacillus.!
Products:!
Theroactive!and!thermostable!asparaginase!(prevention!of!acrylamide!formation!in!cooked!foods)!
CAL!B!Lipase!
Serratia!nuclease!
RNase!T2!
Screening!sets!of!enzymes!in!various!categories,!including!!
Transaminases!
Ketoreductases!
Lipases!and!esterases!
!
!
!
'
'
!
161!
!
!
!!
Codexis'
www.codexis.com!!
200!Penobscot!Drive!
Redwood!City,!CA!94063!
USA!
Tel:!+1:650:421:8100!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
147!employees,!$35!million!to!$40!million!revenues!for!FY!2013.!
Public,!stock!symbol!CDXS,!trades!on!NASDAQ!exchange!in!USA!
65:70%!
Pharmaceutical!and!biocatalysis!enzymes,!industrial!enzymes!(cellulases)!
biofuel!and!bio:based!chemicals.!
Standard!hosts!like!E.,coli,,Pichia,,Trichoderma,,and!Bacillus,!and!additionally!
the!C1!organism!under!license!from!Dyadic!
Pilot!scale!in!house,!multi:ton!scale!via!partnership!
John!Nicols,!CEO;!Peter!Seufer:Wasserthal,!Sr.!VP,!Pharmaceuticals;!Matt!
Tobin,!Sr.!VP,!R!&!D!
Chemtex!for!detergent!alcohols!business,!Lactosan!GmbH!for!enzyme!
production,!Strem!for!product!distribution,!Ampac!and!AMRI!for!fine!
chemicals,!Arch!for!intermediates!production,!cellulase!platform!licensed!
from!Dyadic,!Purolite!for!enzyme!immobilization!
Merck,!Pfizer,!GSK,!Teva,!Roche!and!a!total!of!more!than!50!companies!!
Not!yet!profitable,!$30!million!cash!reserves,!burn!rate!of!about!$15!million!
per!year.!
++!(formerly!offering!an!extensive!catalog,!Codexis!now!mostly!offers!
enzyme!kits!and!customized!biocatalysis!solutions)!
:!
Codexis!was!founded!in!2002!as!a!spin!out!company!from!Maxygen!in!order!to!commercialize!Maxygen’s!
DNA!shuffling!platform!for!biocatalytic!applications.!!The!company!offers!enzymes!both!in!kit!format!for!
screening!and!as!individual!enzymes.!!The!enzymes!are!derived!mostly!via!directed!evolution!to!give!
selections!of!enzymes!with!improved!properties.!!Many!of!the!enzymes!are!developed!for!commercial!
applications!and!are!therefore!stabilized!for!production!processes.!!Codexis!also!works!with!customers!
to!develop!custom!enzymes!and!biocatalytic!routes!as!a!service,!and!generally!provides!the!enzymes!
afterwards!and/or!collects!royalties!on!commercial!processes.!
!
162!
!
!
!!
From!2006!to!2012,!the!company!had!a!major!collaboration!with!Royal!Dutch!Shell!which!was!
terminated!in!2012.!!The!collaboration!provided!funding!to!Codexis!to!develop!biofuels!and!realted!
enzymes.!!Codexis!has!developed!its!cellulase!enzymes,!trade!named!CodeXyme.!!Codexis!has!licensed!
the!C1!expression!and!production!system!from!Dyadic.!Additionally,!Codexis!has!been!developing!a!
process!to!produce!long:chain!alcohols!by!fermentation.!!The!long:chain!alcohol!product!is!called!
CodeXol®.!!The!CodeXol®!project!is!being!scaled!up!in!Italy!in!collaboration!with!Chemtex,!and!a!
demonstration!plant!was!in!initial!phases!of!testing.!!This!plant!uses!a!process!that!first!degrades!
cellulose!using!Codexis’!cellulase!enzymes,!(CodeXyme®),!and!then!ferments!the!resulting!sugar!to!
produce!CodeXol®.!!As!of!late!2013!further!internal!development!of!CodeXol®!has!been!stopped.!
Codexis!recently!announced!that!it!is!expanding!its!focus!to!therapeutic!proteins,!and!will!attempt!to!
partner!in!this!area.!!Other!applications!in!which!Codexis!is!active!are!agriculture,!cosmetics,!and!food.!!
Products!(sold!individually!and!in!screening!kit!format):!
Ketoreductases!
Transaminases!
Amine!oxidases!
Ene!reductases!
Nitrilases!
Halohydrin!dehalogenases!
Baeyer:Villiger!mono:oxygenases!
P450!enyzmes!derived!from!BM3!(CYP102A1)!
!
!
!
'
'
!
163!
!
!
!!
Colotex'BioBTechnology'Co.'Ltd.'
http://www.colotexbiotech.com/!!
Unit!2,!10/E!
Siu!Wai!Industrial!Bldg!
29:33!Wing!Hong!St.!
Cheung!Sha!Wan!Kln!
Hong!Kong!
Tel:!+852:22426933!
Fax:!+852:22426932!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2003!
NA!
Private!
Majority!of!revenues!
Bio:diesel,!textiles,!feed,!food.!!!
NA!
Bulk.!In:house!production.!
NA!
NA!
NA!
NA!
++!
:!
Colotex!is!a!manufacturer!and!supplier!of!enzymes!for!applications!in!textiles,!feed,!and!food.!
Products:!
Alpha:amylases,!Cellulase!
Catalase,!Laccase!
Phytase,!Xylanase!
Glucoamylase,!Beta:amylase,!Pullulanase!
'
!
164!
!
!
!!
Concord'Biotech,'Ltd.'
http://www.concordbiotech.com/!!
B:1002,!Safal!Pegasus!
10th!Floor,!Nr.!Prahladnagar!Garden!
100ft!Road,!Satellite!Road!!
Ahmedabad:380015!Gujarat!
India!
Tel:!+91!79!40321179!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2000!
501:1000!
Private!
Small!sales!of!enzymes.!!Mostly!focused!on!APIs!and!intermediates.!
Penicillin:G!Amidase!Enzyme!(Biocatalyst!for!6:APA,!7:ADCA!&!other!semi:
synthetic!β:lactams)!
NA!
NA!
Sudhir!Vaid!is!the!MD!and!CEO!
NA!
Global!
NA!
+!
:!
In!2000,!this!company!was!split!off!from!DSM.!!It!is!mainly!focused!on!fermentive!production!of!APIs!and!
intermediates!for!pharmaceuticals.!!“The!fermentation!plants!have!a!total!capacity!of!about!450m3!
along!with!the!supporting!equipments.!The!entire!facility!has!an!automated!control!system!which!is!
monitored!and!controlled!by!the!expert!support!team!of!microbiologist,!biochemical!engineers,!
chemists!etc.”!
Products:!
Penicillin:G!Amidase!
!
!
!
165!
!
!
!!
!
Condor'Specialty'Products'
http://www.condorspecialty.com/!!
6.LANGFORE!LANE!
LADERA!RANCH!CA!92694!!
USA!!
Tel:!+1:770:277:0024!
Tel:!+1:949:4298776!!
Fax:!+1:949:4298784!!
Email:!cspı[email protected]!!!
Email:[email protected]!!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1997!
NA!
Private!
Small!
Textile!enzymes.!!!
NA!
Bulk.!In:house!production!not!likely.!
Taskin!Altug,!Owner.!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“Condor!Specialty!Products!is!an!american!company!established!in!Georgia!
since!1997.!We!are!manufacturing!and!formulating!chemical!products!used!in!Denimwash!and!Textile!
industries.”!
Products:!
Laccase!
Cellulase!
!
!
166!
!
!
!!
CPC'Biotech!
www.cpcbiotech.it!!
Via!dei!Mille,!74!!
80121!Napoli!
Italy!
Tel:!+39!(039)!6898029!
Fax:!+39!(039)!6899774!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
Small!to!medium!sized!organization.!
Private!
Likely!significant!portion.!
E.,coli,,Bacillus,!and!many!non:disclosed!microorganisms.!
Production!scale,!up!to!130,000!L!fermentations!
Fabio!Arenghi,!President!
NA!
NA!
++!(estimated)!
++!
++!(expression!and!production,!also!immobilization)!
CPC!Biotech!is!both!a!producer!of!enzymes!for!sale!and!a!contract!organism!for!enzyme!R+D!and!
production.!!The!company!was!spun!out!from!an!antibiotics!producer,!and!therefore!is!closely!
associated!with!the!pharmaceutical!industry.!The!company!does!extensive!contract!manufacturing!oif!
enzymes!for!various!companies.!
The!list!of!enzyme!products!is!extensive!and!includes!the!following:!6:phospho:D:gluconate!
dehydrogenase!6:phospho:D:glucose!isomerase,!Acetate!kinase!(High!specificity!for!Acetate),!Acetyl!CoA!
Synthetase!(high!stability!Lyophilized),!Acetyl!CoA!Synthetase!(high!stability),!Acetyl!esterase!
(Immobilized),!Acetyl!esterase!(Lyophilized),!Acetyl!esterase!(Solution),!Acid!Phosphatase,!Alpha!
fucosidase,!Alpha:xylosidase,!B:Galactosidase,!Cephalosporinase!(Low!Concentration),!Cephalosporinase!
(β:lactamase!type!II),!Citrate!Synthase!(High!Stability),!D:Amino!Acid!Oxidase,!D:Lactate!Dehydrogenase,!
D:Malate!Dehydrogenase,!Gluconate!Kinase,!Glucose!6!Phosphate!Dehydrogenase,!Glutamate!
Dehydrogenase,!Glutamate!Oxaloacetate!Transaminase,!Hexokinase,!Invertase!(beta:fructofuranoside)!
!
167!
!
!
!!
NEUTRAL,!L:Lactate!Dehydrogenase,!L:Malate!Dehydrogenase,!Penicillin!Acylase,!Penicillinase!(β:
lactamase!type!I),!Penicillinase!MP!(low!concentration),!Penicillinase!N!(low!concentration),!Pyruvate!
Kinase!(High!Stability).!
!
!
!
'
'
!
168!
!
!
!!
CreativeBiomart'
45:16!Ramsey!Road!
Shirley,!NY!11967!
!USA!
Tel:!+1:631:559:9269!!
Fax:!+1:631:938:8127!!
Email:!info@creative:biomart.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2005!
51:200!employees!
Private!
Likely!small!
Diagnostics,!food,!feed,!brewing,!pulp!and!paper,!textiles,!leather,!waste!
management,!animal!feed,!leather.!!!
E.,coli!and!others!
Lab!scale!and!bulk.!!In:house!production!unlikely!for!bulk!enzymes.!
NA!
ProteoGen!distributes!CD!Biomart’s!products!in!India.!
Global.!
++!(estimate)!
++!
+!(small!scale)!
Creative!BioMart!primarily!offers!antibodies,!enzymes,!cell!lines,!and!ELISA!kits,!along!with!some!
services!for!using!these!products.!
Products:!
Peroxidase!
Uricase!
Catalase!
Glycerol!kinase!
Glucose!oxidase!
!
169!
!
!
!!
Mannase!
Phytase!
Glucanase!
Cellulases!
Pectinases!
Proteases!
Amylases!
Xylanases!
Purine!nucleotide!phosphorylase!
3:hydroxysteroid!dehydrogenase!
Adenosine!aminohydrolase!
Adenosylhomocysteinase!
Bromelain!
!
'
'
!
170!
!
!
!!
Deltagen'Bioproducts'N.A.'
http://deltagenbiop.com/!!
Marsweg!6!
P.O.!Box!3444!
Curaçao!
Netherlands!Antilles!!
Tel:!!+599!9!!737!–!6411,!!+599!9!!737!:!6166!
Fax:!+599!9!!737!:!8892!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1981!
Small!
Private!
Small!
Dairy,!oil!processing,!meat!processing,!agriculture,!baking,!and!beverages.!!!
NA!
Jaap!Luursema,!Owner!and!General!Manager!
Deltagen!is!a!distributor!for!WeissBiotech!which!is!in!turn!a!distributor!for!
enzymes!from!Verenium.!!Other!suppliers!include!Agargel,!Arla!Foods,!
Biocon!del!Peru,!Edicas,!Fibran,!Haifa,!IOI!Group!Loaders!Croklan,!Kerry!
Foods,!KMC,!Malasian!Food!Industries!A.S.,!Nowicki,!Productos!Bixa,!Tereos,!
TFI,!Usitecnica,!Vikan!Advancing!Hygienig!Cleaning.!
South!America,!Columbia.!
NA!
+!
:!
Deltagen!is!a!distributor!of!ingredients!in!South!America.!!!
Products:!
Transglutamase,!Amylases,!Cellulases,!Oxidases,!Proteases,!Phospholipases!
!
'
'
!
171!
!
!
!!
DIREVO'Industrial'Biotechnology'GmbH'
www.direvo.com!!
Nattermannallee!1!
50829!Köln!(Cologne)!
Germany!
Tel:!+49!221:47448:0!
Fax:!+49!221:47448:111!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
40!employees!
Private!
NA!
Lignocellulosic!material:degrading!enzymes!
NA!
NA!
Jörg!Riesmeier,!CEO!
Direvo!has!sold!a!mannase!business!to!BASF,!and!is!collaborating!with!BASF!
on!the!development!of!a!protease!for!animal!feed.!
NA!
+!(Prominent!investments!by!venture!funds,!revenues!from!sales!to!and!work!
with!BASF)!
+!(only!one!offering!so!far)!
:!
Direvo!works!on!enzymes!that!degrade!lignocellulosic!material!and!the!distillers!grains!left!over!from!
biofuel!and!biochemical!fermentations.!!It!has!sold!one!enzyme!project!to!BASF,!and!has!partnered!with!
them!on!a!protease!for!animal!feed.!!The!company!is!also!involved!in!consolidated!bioprocessing,!and!it!
has!produced!lactic!acid!from!a!cellulosic!feedstock!using!this!technology.!
From!the!company!website:!“Direvo!Industrial!Biotechnology!GmbH!(Direvo!IBT)!was!founded!in!2008!by!
the!shareholders!of!its!mother!company,!Direvo!Biotech!AG,!which!had!been!acquired!by!Bayer!
Healthcare!for!$300!million.!!Direvo!Biotech!AG!commenced!operation!in!2000!as!one!of!the!world’s!
leading!developers!of!directed!evolution!technologies.!Many!times,!over!the!years,!its!proprietary!
evolution!platform!has!demonstrated!the!outstanding!ability!to!develop!tailored!enzymes!for!both!
health!care!and!industrial!applications.!!Direvo!IBT!retained!all!rights!to!the!directed!evolution!
!
172!
!
!
!!
technology!and!intellectual!property!for!application!in!non:pharmaceutical!industries!and!became!fully!
operational!in!early!2009!in!its!state:of:the:art!laboratories!in!Cologne.!!Since!then!we!are!deploying!a!
decade!of!enzyme,!microbe!and!process!know:how!to!develop!bio:based!solutions!for!our!partners!and!
customers!in!the!clean!energy,!clean!chemistry!and!biomass!conversion!markets.”!
Participants!in!funding!rounds!has!included!TVM!V!Life!Science!Ventures!GmbH!&!Co.!KG,!Munich,!
NRW.Bank!Venture!Fonds!GmbH!&!Co.!KG,!Düsseldorf,!Sparkasse!Köln:Bonn!mbH,!Cologne,!Mulligan!
BioCapital,!Hamburg,!Danisco!Venture!ApS,!Copenhagen,!and!several!private!investors.!
Product:!
Sells!BluZy®:D,!which!is!an!enzyme!that!improves!the!digestibility!of!distillers!grain!for!use!as!feed!for!
non:ruminant!animals.!!This!may!be!a!phytase.!!The!company!is!also!developing!cellulase!enzymes.!
!
'
'
!
173!
!
!
!!
Discovery'Biocatalysts'Limited'
http://www.discovery:bc.co.uk/!!
5!Leslie!Avenue!
Bury!BL9!8DL!
UK!!
Tel:!+44!(0)!7904195605!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2012!
1:5!employees!
Private!non:profit!
100%!
Biocatalysis!
E.,coli,
Lab!scale!
Gareth!DeBoos,!Director!of!Discovery!and!Managing!Director!
Most!biocatalysts!are!from!the!lab!of!Prof.!Nicholas!J.!Turner!at!the!
University!of!Manchester!
Global!
NA!
++!
+!(only!small!amounts,!outsources!to!Biocatalysts!Ltd!for!larger!scale)!
Discovery!Biocatalysts!is!a!non:profit!organization!with!the!goal!of!getting!biocatalysts!into!the!hands!of!
R+D!professionals!as!quickly!as!possible!without!any!intellectual!property!concerns.!!The!organization!
expressly!disavows!collecting!royalties,!stating!that!it!simply!sells!kits!and!will!tell!customers!the!identity!
of!the!enzymes!so!that!the!customer!may!scale!up!and!develop!them!as!they!see!fit.!!Discovery!is!
seeking!additional!enzymes!from!academic!labs!that!it!can!offer!in!kit!format.!!!
Products:!
Monoamine!oxidases,!kit!of!10.!!!
'
'
!
174!
!
!
!!
DNA'Polymerase'Technology,'Inc.'
www.klentaq.com!!
1508!South!Grand!Blvd.!!
St.!Louis,!Missouri!63104!!
USA!
Tel:!+1:314:680:0575!!
Fax:!+1:314:754:9556!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
About!5:20!employees!
Private!
Significant!revenue!stream!
Enzymes!for!DNA!modification.!!Polymerases.!
NA!
Laboratory!research!scale!
John!Hartman,!Business!Manager;!Wayne!M.!Barnes,!President!and!Founder!
NA!
NA!
NA!
++!
:!
DNA!Polymerase!Technology!was!created!by!Wayne!M.!Barnes,!a!professor!at!Washington!University!in!
St.!Louis.!!The!company!sells!DNA!polymerases!and!molecular!biology!kits!containing!the!enzymes.!
Products:!
DNA!polymerase!and!kits!thereof!
!
!
'
'
!
175!
!
!
!!
Dong'Nam'Chemicals&'Equipments'Corporation'
www.dongnamlab.com!!!
33/8!Luu!Nhan!Chu!Str.!
Ward!5,!Tan!Binh!Dist.,!HCM!City!
Vietnam!
Tel:!(+84.8)!6292.3745!:!6292.3731!:!6292.3773!
Fax:!(+84.8)!6292.3750!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
NA!
Small!
Diagnostics!and!carbohydrate!modification!
NA!
Lab!scale.!No!in:house!production.!
NA!
NZYTech!
Local!
NA!
+!
:!
Dong!Nam!sells!a!wide!variety!of!scientific!equipment!and!reagents,!including!a!selection!of!enzymes!
from!NZYTech.!
From!the!website:!“Dong!Nam!Chemicals&!Equipments!Corporation!supply!and!installation!of!
equipment!:!scientific!instruments,!consumables,!chemicals,!Culture!Media,!Reagents!for!laboratories!in!
the!Healthcare,!Education,!Research,!Enviroment,!Production!(Pharmaceutical,!Food!&!Beverage,!
Fishery),!Center!of!!Analytical!Service!and!Government.”!
!
176!
!
!
!!
!
'
'
!
177!
!
!
!!
DSM'
http://www.dsm.com/!!
Het!Overloon!1!
6411!TE!Heerlen!
The!Netherlands!
Tel:!+31!(0)45!578!8111!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1902!
23,500!employees!
Public:!DSM!
Significant!minority!revenue!stream!
Biofuels,!baking,!brewing!and!winemaking,!dairy,!egg!processing,!fruit!
processing,!animal!feed.!
Many!
Multi:ton.!!In:house!production.!
Feike!Sijbesma,!CEO!
Novozymes!and!DSM!co:manufacture!and!co:market!some!animal!feed!
enzymes.!!Partnered!with!Codexis!for!access!to!biocatalysts!for!DSM’s!
biocatalyst!route!development!and!manufacturing!services.!!Partnered!with!
POET!to!use!DSM’s!cellulase!package!in!a!second:generation!bioethanol!
plant.!Partners!with!Almac!to!offer!biocatalysis!screening!and!enzymes.!
Global!
++!
+++!
:!
DSM!is!a!conglomerate!that!has!a!leading!presence!in!the!enzyme!manufacturing!industry!in!food!and!
feed!applications.!!Through!its!partnership!with!Novozymes!on!the!Ronozyme!family!of!phytases,!
proteases,!and!carbohydrate:degrading!enzymes,!it!is!a!leader!in!animal!feed!additives.!!The!company!
has!developed!a!cellulase!platform!for!second:generation!biofuels.!!DSM!also!uses!enzymes!as!
biocatalysts!internally!for!the!manufacture!of!pharmaceutical!small!molecules.!!Notably,!the!company!
has!developed!the!recombinant!expression!of!pig!liver!esterase!(PLE),!and!the!recombinant!source!of!the!
enzyme!allows!it!to!be!a!Kosher!non:animal:derived!product.!!The!so:named!Pharma!PLE!is!thus!valuable!
for!drug!manufacture,!which!DSM!is!willing!to!conduct!in!house!on!a!service!basis.!!DSM!has!collections!
of!thousands!of!other!enzymes!as!well!which!it!uses!to!develop!routes!for!small!molecule!production!in!
house!or!on!a!service!basis.!
!
178!
!
!
!!
From!the!company!website:!“Royal!DSM!N.V.!creates!solutions!that!nourish,!protect!and!improve!
performance.!Its!end!markets!include!human!and!animal!nutrition!and!health,!personal!care,!
pharmaceuticals,!automotive,!coatings!and!paint,!electrical!and!electronics,!life!protection!and!housing.!
DSM!manages!its!business!with!a!focus!on!the!triple!bottom!line!of!economic!performance,!
environmental!quality!and!social!responsibility,!which!it!pursues!simultaneously!and!in!parallel.!DSM!has!
annual!net!sales!of!about!€8!billion!and!employs!some!22,700!people!worldwide.!The!company!is!
headquartered!in!the!Netherlands,!with!locations!on!five!continents.”!
Products:!
Cellulases!
Proteases!
Xylanases!
Beta:glucanases!
Phytases!
Amylases!
Hemicellulases!
Pectinases!
!
'
'
!
179!
!
!
!!
DuPont'
http://www.dupont.com/!!
1007!Market!Street!
Wilmington,!DE!19898!
USA!
Tel:!+1:302:774:1000!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1802!
70,000!employees!
Public:!DD!
Textiles,!detergents,!pulp!and!paper,!food,!baking,!winemaking,!brewing,!
carbohydrate!processing,!biofuels,!animal!nutrition,!dairy,!oil!processing,!etc.!
Many!
Multi:ton.!In:house!production.!
Ellen!J.!Kullman,!CEO!
Numerous.!!Partners!with!DSM!in!animal!nutrition!enzymes.!
Global!
+++!
+++!
:!
DuPont!is!a!large!conglomerate!involved!in!the!manufacture!of!specialty!chemicals!and!materials.!!The!
company!entered!the!enzyme!space!in!2011!with!its!purchase!of!Danisco.!!DuPont!considers!the!enzyme!
business!to!be!a!high:growth!industry,!and!has!been!hiring!strongly!in!research!supporting!its!
commercial!offerings.!!The!company!has!a!strong!catalog!of!a!range!of!industrial!enzymes,!and!sells!
through!distributors!worldwide.!!DuPont!also!has!one!of!the!leading!cellulase!enzyme!packages!for!
second:generation!biofuels!production.!!
Products:!
Extensive!product!line!across!the!following!categories:!
Cellulases!
Proteases!
Xylanases!
!
180!
!
!
!!
Beta:glucanases!
Phytases!
Amylases!
Hemicellulases!
Pectinases!
Lipases!
!
'
'
!
181!
!
!
!!
Dyadic'International'Inc.'
http://dyadic.com/!!
140!Intracoastal!Pointe!Drive!
Suite!404!
Jupiter,!FL!33477:5094!
USA!
Tel:!+1:561:743:8333!
Fax:!+1:561:743:8343!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1979!
38!employees,!about!$15!million!annual!revenues!
Public:!DYAI!
Revenues!from!(1)!licensing!its!patented!and!proprietary!technologies;!(2)!
selling!its!proprietary!enzymes;!and!(3)!conducting!R&D!activities!for!third!
parties.!
Pulp!and!paper,!textiles,!food!and!beverage,!biomass!processing.!
Trichoderma!and!proprietary!C1!fungal!strains!(Myceliopthora,thermophila)!
Access!to!a!150,000!L!fermentor!
Mark!A!Emalfarb,!Chairman/President/CEO!
Dyadic!has!licensed!its!C1!platform!to!Codexis,!Abengoa!and!BASF!
Global!
++!(profitable!products)!
++!
++!
Dyadic!is!known!for!its!unique!expression!platform—the!C1!fungal!microorganism—which!enables!the!
expression!and!larege!scale!manufacture!of!enzymes.!!The!company!earns!revenue!by!licensing!this!
platform,!as!well!as!in!contract!R&D!and!manufacturing,!and!from!the!sale!of!industrial!enzymes.!
Enzyme!Products:!
Cellulases!
Proteases!
Amylases!
Xylanases!
!
182!
!
!
!!
Endo:glucanases!
Fibrezyme!G5000:!Enzyme!for!refining!pulp!that!reduces!energy!needs!by!improving!pulp!flow.!
Trademarks:!
Fibrezyme®!
Green!Sugars®!
DyadicINSIDE®!
'
'
!
183!
!
!
!!
DyStar'
http://www.dystar.com/!!!
Am!Prime!Park!10:12!!
65479!Raunheim!!
Germany!
Tel:!+49!6142!4072!0!
Fax:!+49!6142!4072!2000!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1995!
2,500!employees!
Private!
Small!
Textiles!!!
NA!
NA.!!In:house!production!not!likely.!
Harry!Dobrowolski,!Group!CEO!&!President!
NA!
Global!
+++!
:!
From!the!company!website:!“DyStar!is!a!leading!provider!of!products!and!services!for!the!textile!and!
leather.”!industries.!
Product:!
Sera!Zyme!C:PE!(a!pectinase),!for!bio!scouring!to!remove!waxes!and!oils!from!cotton!fabrics.!
Catalase!
!
!
'
'
!
184!
!
!
!!
Elanco'
http://www.elanco.us/!!
2500!Innovation!Way!
Greenfield,!IN!46140!!
USA!
Tel:!+1:877:Elanco1!(1:877:352:6261)!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1960!
2,500!employees!
Subsidiary!of!public!company!Eli!Lilly!
Small!
Animal!feed!enzymes.!!!
NA!
Jeff!Simmons,!President!
NA!
Global!
+++!
+!
:!
Elanco!is!the!name!of!the!Eli!Lilly!business!unit!for!animal!health!and!nutrition.!!Elanco!purchased!animal!
feed!enzyme!developer!ChemGen!in!early!2012,!and!now!sells!its!enzymes.!
Products:!
Xylanase!
Beta:mannanase!
Beta:glucanase.!
!
'
'
!
185!
!
!
!!
ElementalEnzymes'
1601!South!Providence!Road!
Suite!120!
Columbia,!MO!65211!
USA!
Tel:!+1:913:269:7873!or!+1:314:341:1442!
Email:[email protected][email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2011!
2!employees!
Private!startup!
Pending,!but!anticipated!to!be!the!major!revenue!source.!
Soil!and!water!remediation!
Bacterial!
Small.!!In:house!production.!
Brian!Thomson,!President!and!CEO!and!Co:Founder;!Katie!Thomson,!Vice:
President!and!Co:Founder!
NA!
NA!
NA!
(Pending)!
:!
Elemental!Enzymes!is!a!small!startup!created!by!the!husband:and:wife!team!of!Brian!and!Katie!
Thomson.!!The!company!has!licensed!enzyme!production!technology!from!University!of!Missouri,!and!
the!technology!is!focused!on!enzyme!stabilization.!!!The!professors!at!the!University!responsible!for!the!
technology!are!George!Stewart!and!Chung:ho!Lin.!!The!company!was!funded!by!St.!Louis!Arch!Angels!
Network!($170,000).!!The!technology!appears!to!be!enzyme!immobilization!onto!biochar.!!!
!
!
'
'
!
186!
!
!
!!
EMELCA'Bioscience'
www.emelcabio.com!!!
Kapucinessenstraat!30!
B:2000!Antwerpen!
Belgium!
Tel:!+32!!484629800!
Fax:!+32!32262729!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Small!!
Diagnostic!and!carbohydrate:active!enyzmes.!
NA!
No!in:house!production.!!Lab:scale!supplier!
NA!
EMELCA!sells!enzymes!from!NZYTech!
NA!
NA!
++!
:!
From!the!website:!“EMELCA!Bioscience!commercialises!reagents!(antibodies,!recombinant!proteins,!
peptides,!ELISA!kits,!products!for!use!in!molecular!biology,!primers,!enzymes,!biochemicals)!to!
diagnostic!and!research!laboratories.”!!!
Products:!
!
187!
!
!
!!
!
!
'
'
!
188!
!
!
!!
Emp'Biotech'GmbH'
http://www.empbiotech.com/!!
Robert:Rössle:Str.!10!
D:13125!Berlin!
Germany!
Tel:!+49!30:9489:2201!
Fax:!+49!30:9489:3201!
E:mail:[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1993!
Small!
Private!
Small!
Modified!proteases,!immobilized!proteases.!
NA!
Small.!!In:house!production!
Derek!Levison,!Uwe!Möller,!both!managing!directors!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“Founded!in!1993!with!a!strong!focus!in!organic!synthesis,!biomolecular!
modification!and!purification,!emp!BIOTECH!provides!quality!reagents!and!services!for!the!life!science!
community.!We!manufacture!fine!chemicals,!DNA!synthesis!reagents,!tools!for!molecular!biology,!
chromatography!media!and!related!products.!In!addition,!we!provide!contract!organic!synthesis,!protein!
and!nucleic!acid!labeling,!peptide!synthesis,!consulting!and!analytical!services.!Furthermore,!we!have!an!
ongoing!interest!in!the!fields!of!non:radioactive!detection!systems,!synthetic!organic!and!polymer!
chemistries!and!purification!services.!Our!novel!detection!platforms!combine!non:enzymatic!
chemiluminescence!signal!amplification!and!fluorescence!enhancement!strategies,!both!supported!by!
synthetic!innovations.”!
Products:!
Modified!proteases,!Immobilized!proteases!
!
189!
!
!
!!
Enantis,'s.r.o.'
www.enantis.com!!
Palackeho!trida!1802/129!
612!00!Brno!
Czech!Republic!
Tel:!+420:605!566!804!
Fax:!+420:549!496!302!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
1:10!employees.!!Revenues!of!60,000!Euros!in!2010,!and!less!than!that!in!
previous!years.!!
Private:!Enantis!is!established!in!close!collaboration!with!Loschmidt!
Laboratories!at!Masaryk!University!in!Brno,!Czech!Republic.!
Small!
Haloalkane!dehalogenases!for!degradation!of!toxic!sulphur!mustards!
NA!
Lab!scale.!!In:house!production.!
Zbynek!Prokop,!CEO!
The!company!previously!had!partnerships!with!LentiKats,!BRAIN!AG,!and!
others!but!no!new!partnerships!have!been!announced!since!2009.!
NA!
NA!
+!(about!8!haloalkane!dehalogenases!are!listed)!
:!
Enantis!is!a!spin!off!from!Masaryk!University!and!several!members!of!the!university!have!been!or!are!
part:time!employees!of!the!company.!!!
From!a!recent!report:!“Enantis!was!established!in!2006!as!the!first!biotechnology!start:up!from!Masaryk!
University,!Czech!Republic.!The!company!collaborates!tightly!with!the!Loschmidt!Laboratories!at!
Masaryk!University!in!the!development!of!modern!technologies!for!sustainable!growth.!Enantis!provides!
consulting!and!R&D!services!in!the!field!of!enzyme!technologies!and!protein!engineering!for!biomedical,!
environmental,!agrochemical!and!military:defense!applications.!Enantis!manufactures!own!products!
based!on!dehalogenase!enzymes:!whole:cell!and!enzyme!catalysts,!decontamination!kits,!biosensors!
and!detection!strips,!optically!pure!chemicals!and!fluorescence!probes.!Our!clients!are!pharmaceutical,!
biotechnological!and!military:defense!companies.”!
!
190!
!
!
!!
Products:!
Haloalkane!dehalogenases!
!
!
'
'
!
191!
!
!
!!
Enartis'(Esseco'Srl)'
http://www.enartis.com/!!
www.essecogroup.com!
Via!S.!Cassiano,!99!!
San!Martino,!28069!Trecate!–!NOVARA!
Italy!
Tel:!+39!0321!790!1!
Fax:!+39!0321!779646!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1921!
Large!
Network!of!companies!are!part!of!the!Esseco!Group!of!Italy!
Winemaking!enzymes.!
Several!
Multi:ton.!!In:house!production!not!likely.!
Piero!Nulli,!CEO!
NA!
Global!
+++!
+++!(extensive,!detailed,!and!specialized!in!wine!enzymes)!
:!
Enartis!is!a!worldwide!network!of!companies!that!distribute!winemaking!goods,!services,!and!light!
equipment.!!The!companies!are!all!part!of!the!Esseco!Group,!and!are!called!various!names!in!the!
different!regions!they!serve.!!For!example,!in!the!USA,!the!local!branch!of!the!company!is!called!Enartis!
Vinquiry.!!All!of!the!various!company!websites!can!be!accessed!centrally!via!www.enartis.com.!!!
Products:!
Pectinases,!Hemicellulases,!Beta:glucanase,!Lysozyme,!Proteases,!Beta:glycosidase!
'
'
!
192!
!
!
!!
Engrain'
http://www.engrain.us/!!
2031!Fort!Riley!Boulevard!
Manhattan,!KS!66502!
USA!
Tel:!+1:785:539:1100!
Fax:!+1:785:539:1102!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
5:10!employees!
Private!
Significant!revenue!contributor,!as!custom!mixtures!of!enzymes!and!other!
materials.!
Milling!and!baking!enzymes.!!!!
Engrain!are!blenders!of!product!and!have!no!enzyme!manufacturing!abilities.!
Vaughn!Studer,!CEO!
Complete!network!of!global!product!support!through!!Research!Products!
Company!and!Specialty!Enzymes!&!Biochemical!Group!
Multiple!countries!
NA!
++!
:!
From!the!website:!“Engrain!offers!the!most!advanced!products!in!the!marketplace.!We!provide!a!full!
portfolio!of!performance,!nutrition!and!appearance!products!for!your!milling,!bakery!and!cereal!food!
processing!and!pasta!applications.!Our!products!will!help!you!increase!bread!volume,!optimize!pasta!
texture!and!enrich!your!baked!goods.!You!will!be!able!to!see!the!difference!we!can!make!in!your!product!
line!and!your!bottom!line.”!
Products:!
Though!not!specified,!the!offerings!are!generaelly!blends!of!carbohydrate:degrading!enzymes!and!
proteases.!
'
'
!
193!
!
!
!!
ENGroup'
www.engroup.cn!!
F.1,!West!Building!of!IAPPST!
CAAS,!No.2!Yuanmingyuan!West!Road!
Haidian!District,!Beijing,100193!
China!
Tel:!+86!10!6289!0139!
Fax:!+86!10!6283!3152!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2001!
25:50!employees!
Private!
Nearly!all!revenues!from!enzyme!sales!
Animal!feed.!
Not!revealed,!but!likely!standard!hosts!including!Bacillus,,Aspergillus,,and,
Trichoderma.!
Bulk.!Annual!production!of!40,000!tons!in:house.!
NA!
EN!Group!includes!the!following!subsidiaries:!
EN!Bio:tech!Limited!Company!
Jiangsu!Yinong!Bio:engineering!Co.,!Ltd.!
Shuyang!Yinong!Trade!Co.,!Ltd.!
Yinong!International!Biotechnology!Private!Ltd.!(in!Singapore)!
USA,!Russia,!Ukraine,!Thailand,!Vietnam,!South!Korea!and!other!regions.!
NA!
++!
:!
EN!Group!is!a!manufacturer!of!bulk!animal!feed!enzymes.!
Products:!
Phytase,!Xylanase,!Mannanase,!Alpha:galactosidase,!Cellulase!
Beta:glucanase,!Protease,!Amylases!
!
194!
!
!
!!
Enmex'
http://www.enzymes.com.mx/!!
Río!Lerma!No.!228!
Fracc.!Ind.!San!Nicolas!
Tlalnepantla,!Edo.!de!México!54030!
Mexico!
Tel:!+52!(5)!565!5999,!!(5)!565!5992!
Fax:!+52!(5)!390!4826!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1961!
NA!
Private!
Most!sales!are!enzymes!
Starch!processing,!brewery,!leather,!detergents,!textiles,!fruit!juice,!baking,!
dairy,!animal!feed.!
Non:GMO!microorganism!fermentation.!
Multi:ton.!In:house!production.!
NA!
CPI,!Gamesa,!Cognis,!Kraft,!Ciba,!etc.!
NA!
NA!
+++!
:!
EnMex!started!as!an!importer!of!enzymes,!but!has!since!built!substantial!capacity!in!manufacturing!
enzymes!in!house.!!It!distributes!enzymes!and!enzyme!mixtures.!
Products:!
Proteases!
Alpha:amylases!
Glucoamylases!
Invertase!
Dextranase!
!
195!
!
!
!!
Beta:glucanase!
Pectinase!
Cellulase!
Catalase!
Rennet!
Lipase!
Bromelain!
!
'
'
!
196!
!
!
!!
Enzagen,'Ltd'
http://www.enzagen.com!
Newton!Hall,!Town!Street!
Newton!
Cambridge!CB22!7ZE!!
UK!
Tel:!!+44!(0)774!9225986!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
1!person!
Private!
Biocatalysis!
NA!
Lab!scale.!!No!in:house!production.!
Steve!Taylor,!PhD,!Owner.!
NA!
NA!
NA!
+!
:!
Enzagen!is!a!small!company!that!consults!in!biocatalysis,!offers!procurement!services!and!supplies!
biocatalysts,!and!is!a!CRO!for!bioactive!small!molecules!in!drug!discovery.!
Products:!
Kits!of:!
Lipases!
Proteases'
!
!
197!
!
!
!!
Enzybel'International'
www.enzybel.com!!
ZAE!de!Ghislenghien!
Rue!des!Gaulois,!7B!
7822!Ghislenghien!
Belgium!
Tel:!+32(0)!68/44!99!61!
Fax:!!+32(0)!68/44!99!62!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
NA!
Private!
Food,!pet!food,!nutraceuticals,!cosmetics!and!pharmaceuticals!
Extraction!from!plant!tissue!
NA!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“Founded!in!January!2006,!Enzybel!International!had!as!primary!mission!to!
answer!the!world:wide!needs!of!plant!proteases!for!food,!pet!food,!nutraceutical,!cosmetic!and!
pharmaceutical!industries.”!
Products:!
Papain!
Bromelain!
Ficin!
Actinidin!
!
198!
!
!
!!
Enzymatic'Deinking'Technologies,'LLC!
http://www.edt:enzymes.com/!!
3975!Steve!Reynolds!Boulevard!!
Norcross,!GA!30093!!
USA!!
Tel:!+1:678:735:3500!
Fax:!+1:678:735:3501!
Email:!ask@edt:enzymes.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1994!
51:200!employees!
Private!
Pulp!and!paper!
NA!
NA!
NA!
NA!
NA!
++!
:!
Despite!its!name,!Enzymatic!Deinking!Technologies!develops!and!sells!enzymes!for!a!multitude!of!pulp!
and!paper!applications!beyond!just!deinking!applications.!!!
Products:!
Cellulases!
Endo:glucanases!
Cellobiohydrolases!
Hemicellulases!
Mannanases!
!
199!
!
!
!!
Xylanases!
Pectinases!
Lipases!
Peroxidases!
Glucose!oxidase!
Esterase!
Protease!
Amylases!
Beta:glucosidases!
Laccases!
!
!
'
'
!
200!
!
!
!!
Enzymatics'
http://www.enzymatics.com/!!
Suite!407J!!
100!Cummings!Center!!
Beverly,!MA!01915!
USA!
Tel:!+1:888:927:7027!
Tel:!+1:978:927:7027!
Fax:!+1:978:867:5724!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
51:200!employees!
Private!
Life!science!and!molecular!biology!enzymes,!DNA!and!RNA!modification!
enzymes.!
NA!
Lab!scale!to!medium!scale.!!In:house!production.!
Jon!DiVincenzo,!President!and!CEO!
NA!
NA!
NA!
+++!(strong!selection!of!enzymes,!about!100)!
+!
From!the!company!website:!“Enzymatics!is!an!independent,!ISO!13485:2003!certified!OEM!
manufacturer!of!enzymes!that!brings!to!the!marketplace!a!unique,!quality!oriented,!and!customer!
focused!approach!to!protein!production.!The!company!was!founded!in!2006!to!specifically!address!the!
needs!of!commercial!entities!engaged!in!the!development,!manufacture,!and!distribution!of!platforms!
dedicated!to!nucleic!acid!identification.”!
!
!
!
201!
!
!
!!
Products:!
Extensive!list!of!about!50!enzymes!that!includes:!Ligases,!Restriction!enzymes,!Polymerases,!
Phosphatases,!Reverse!transcriptases!
!
!
202!
!
!
!!
Enzyme'Development'Corporation'
www.EnzymeDevelopment.com!!
505!8th!Ave,!Suite!1500!!
New!York,!NY!!10018!!
USA!
Tel:!+1:212:736:1580!
Fax:!+1:212:279:0056!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Contract!Manufacturing!
!
1953!
About!10!employees,!about!$20!million!in!revenues!
Private!
100%!of!sales!are!enzymes!or!assays!for!the!enzymes.!
Animal!feed,!baking,!brewing!and!winemaking,!dairy,!juice,!textiles.!
Aspergillus,,Rhizopus,,Candida,,Mucor,,Bacillus,!and!Trichoderma!expression,!
and!isolation!of!enzymes!from!plants!and!animal!tissue.!
Bulk.!!Some!products!made!in:house.!
Peter!Moodie,!President!
Partnership!with!!Fytozimus!Biotech!to!distribute!Fytozimus’!Aspartic!Acid!
Protease!in!the!USA!
NA!
++!(estimated)!
++!(strong!selection)!
:!
From!the!company!website:!“Enzyme!Development!Corporation!manufactures!and!supplies!enzyme!
products.!Its!enzyme!products!include!Its!products!are!used!in!various!applications,!including!animal!
feed,!baking,!brewing,!dairy,!ethanol,!flavor,!juice,!nutraceutical,!petfood,!tenderizer,!textile,!wine,!and!
other!applications.!The!company!was!founded!in!1953!and!is!based!in!New!York,!New!York.”!
Products:!
Catalase!
Cellulases!
Lipases!
!
203!
!
!
!!
Esterases!
Pectinases!
Proteases!
Xylanases!
Tannase!
Urease!
Lysozyme!
Bromelain!
Papain!!
!
!
204!
!
!
!!
!
Enzyme'Solutions'
http://www.enzymesolutions.com.au/!!
26!Research!Drive!
Croydon!South,!VIC,!3136!
Australia!
Tel:!(03)!9761!7999!
Fax:!(03)!9761!7899!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1997!
10:20!employees!
Private!
Most!sales!are!enzymes.!
Enzymes!for!Baking,!Brewing,!Cleaning,!Dairy,!Ethanol,!Fruit!Juice!and!Olive!
Oil!production,!Grain!Processing,!Paper,!Protein!Processing,!!Specialty!
Enzymes,!Therapeutic,!Textiles,!Waste!Treatment!&!Wine.!
Manufacturing!not!done!in!house!
Geoff!Bearzatto,!Managing!Director!(CEO)!and!Co:Founder!
DuPont!and!Godo!Shushei!are!the!suppliers!of!most!of!the!enzymes!that!
Enzyme!Solutions!distributes.!
Australian!market!primary,!but!exports!to!other!countries!as!well!
++!(estimated!to!be!profitable!and!stable)!
+++!(Wide!variety!from!reputable!suppliers)!
:!
From!the!company!website:!“Established!in!Melbourne!over!15!years!ago!:!the!enzymes!originate!from!
DuPont!Industrial!Biosciences.,!Danisco!Australia!Pty!Ltd,!and!Godo!Shusei!Co!Ltd!amongst!other!key!
strategic!partners.!!Additionally,!we!formulate!and!produce!many!of!our!own!enzyme!based!products!
using!the!experience!we!have!gained!over!many!years.!!Close!collaboration!with!our!customers!can!
achieve!unique!products!and!processes.!!Examples!of!locally!produced!products!are!Optivin®,!Oleo!Flo®,!
Fermassist®,!Acidolact®,!ProtiBond!TG®,!Solvabrew!and!OptiCarb.”!
!
!
205!
!
!
!!
Products:!
Amylases!
Proteases!
Lipases!
Xylanases!
Papain!
Beta:glucanase!
Glucoamylase!
Cellulases!
Mannanase!
Lactase!
Pectinases!
Bromelain!
Hemicellulases!
Catalase!
Glucose!oxidase!
Lysozyme!
Beta:glycosidase!
!
!
!
206!
!
!
!!
!
Enzyme'Solutions'(USA)'
2105!Forrest!Park!Drive.!
Garrett,!IN!46738!
USA!
Tel:!+1:260:497:0851!or!+1:800:523:1323!
Fax:!+1:260:497:0512!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
2000!
Small!
Private!
Major!revenue!stream!as!part!of!formulated!products.!
Detergents,!cleaning!applications.!
NA!
Tim!Beck,!CEO!
NA!
NA!
NA!
+!(formulated!into!cleaning!products)!
++!
!
Enzyme!Solutions!provides!cleaning!agents,!many!of!which!contain!enzymes.!
From!the!company!website:!“Enzyme!Solutions!is!a!U.S.!based!manufacturer!of!enzymes!and!enzyme!
products.!All!manufacturing,!testing,!formulation!and!bottling!are!conducted!in!its!manufacturing!plant,!
located!in!Fort!Wayne,!Indiana.”!
Products:!
Proteases!
Lipases!
Amylases!
!
!
207!
!
!
!!
Enzyme'Supplies'Limited'
http://www.enzymesupplies.com/!!
John!Eccles!House!
Robert!Robinson!Avenue!
The!Oxford!Science!Park!
Oxford!OX4!4GP!
UK!
Tel:!+44!(01865)!338!095!
Fax:!+44!(01865)!338!100!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2010!or!ealier!
Small!
Private!
Enzymes!for!Alcohol,Biofuels,!Biomass,!Brewing,!Dairy,!Detergents,!Food!
functionality,!Fruit!&!vegetable,!Pulp!&!paper,!Starch.!!Additional!enzymes!
available!for!specialty!applications,!mostly!in!diagnostics.!
None!
Paul!Richards,!Managing!Director!(CEO)!
Suppliers!are!not!indicated,!but!Enzyme!Supplies!appears!to!be!a!distributor!
of!enzymes!with!no!manufacturing!capabilities.!
NA!
NA!
++!!
:!
From!the!company!website:!“Our!mission!is!simple;!to!provide!a!comprehensive!range!of!enzymatic!&!
biological!solutions!for!our!customers!to!help!them!maximise!the!potential!of!their!businesses!&!
products.”!
Products:!
Amylases!
!
208!
!
!
!!
Glucoamylase!
Cellulases!
Proteases!
Xylanases!
Phytases!
Papain!
Lactase!
Catalase!
Lipases!
Pectinases!
Alpha!chymotrypsin!!
Acetyl!Cholinesterase!(AChE)!!
Acid!phosphatase!!
Acylase!!
Alkaline!phosphatise!!
Alcohol!dehydrogenase!!
Alpha:glucosidase!!
Beta:glucosidase!!
Bromelain!
Butyl!Cholinesterase!!
Carbonic!anhydrase!!
Chymotrypsin!!
Chymotrypsinogen!!
Deoxyrobonuclease!(DNase)!!
Elastase!!
!
209!
!
!
!!
Glutamate!dehydrogenase!!
Hyaluronidase!!
L:Arginase!!
Lactoperoxidase!!
Malate!dehydrogenase!!!
Mutarotase!!
Peroxidase!(horseradish)!!
Pepsin!!
Phospholipase!!
Phosphorylase!!
Ribonuclease!!
Sulphatase!!
Trypsin!!
Transaminase!!
Urease!!
Uricase!!
!
!
!
!
!
210!
!
!
!!
EnzymeKing'Biotechnology'Co.'Ltd.'
Hi:Tech!!Economic!Park,!YUanbaoshan!Dist.!
Chifeng!City,!Inner!Mongolia,!China!
China!
Tel:!+86:10:853:25499!
Fax:!+86:10:853:25499!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
Over!100!employees.!
Private!
All!revenues!from!enzyme!sales.!
Pharmaceutical,!food,!cosmetics,!research.!
Extraction!from!animal!tissue.!
Bulk.!In:house!manufacture.!
Henry!Chong,!Vice!President!
NA!
NA!
NA!
+!
:!
From!the!website:!“Enzymeking!Biotechnology!Company!Limited.!specializes!in!manufacture,!
distribution,!and!supply!pharmaceutical!raw!materials!for!application!in!the!fields!of!pharmaceutical,!
scientific!research,!foods!&!cosmetics.”!
Products:!
Trypsin!
Chymotrypsin!
Kallidogenase!(kallikrein;!catalyzes!conversion!of!kallidin!from!kinnogen;!claimed!to!reduce!blood!
pressure!and!sold!as!a!pharmaceutical!in!China,!but!not!in!USA.)!
Ribonuclease,!Deoxyribonuclease!
!
211!
!
!
!!
Enzymes'Naveen'
9,!Spencer!House!
Karnataka!82,!Coles!Road!
Frazer!Town,!Bangalore!560005!
India!
Tel:!+919342190781!
Tel:!+91:80:25309841!
Fax:!+91:80:25587055!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1995!
5:10!employees!
Private!
Important!minority!revenue!source!
Food,!textiles,!effluent!treatment.!
NA!
Bulk.!!No!in:house!production!
Naveen!Jaidka!
NA!
NA!
NA!
+!
NA!
Enzymes!Naveen!is!a!re:seller!of!enzymes!and!other!products!related!to!food!processing,!textiles,!
effluent!treatment,!and!other!applications.!!
Products:!
Laccase!
Cellulase!
Amylase,!Glucoamylase!
Xylanase!
Protease,!Lipase!
!
!
212!
!
!
!!
EnzymeWorks'Inc'
603!Gangcheng!Rd.!
Zhang!Jiagang!
Jiangsu!215600!
China!
Tel:!+86!512!888!38789!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
About!2011!
>100!
Private!
Mostly!focused!on!contract!R+D!and!manufacture.!
Biocatalysis!!!
NA!
Multi:ton!scale.!!In:house!production.!
Junhua!(Alex)!Tao,!Founder!
NA!
NA!
NA!
++!
++!(large!scale,!short!operational!history)!
EnzymeWorks!offers!contract!research!and!manufacturing!for!biocatalysts,!and!also!has!a!small!catalog!
of!enzymes.!!!EnzymeWorks!targets!pharma!and!generics!companies,!fine!chemicals!producers,!flavor!
and!fragrance!companies,!and!agriculture.!!The!company!also!applies!its!enzymes!and!traditional!
chemical!strengths!to!manufacturing!of!APIs!and!intermediates!and!to!the!production!of!secondary!
metabolites.!!EnzymeWorks’!website!explains!that!it!has!research!capabilities!in!protein!engineering,!
enzyme!purification,!enzyme!formulation,!enzyme!immobilization,!fermentation!optimization,!
biotransformation!screening,!process!development,!drug!metabolite!synthesis,!and!process!
optimization.!
Products:!
Acyltransferase!
!
213!
!
!
!!
Aldolase!
Amine!oxidase!
Amino!acid!dehydrogenase!
Cytochrome!P450!monooxygenases!
Dehydrogenases!for!cofactor!regeneration!
Ketoreductases!
Nitrilases!
Amidases!
Enolate!reductases!
Glycosidases!
Nitrile!hydratase!
Nitro!reductase!
Oxynitrilase!
'
'
!
214!
!
!
!!
'
Enzymicals'AG'
Walther:Rathenau:Strasse!49a!
17489!Greifswald!
Germany!
Tel:!+49:3834:51547:0!
Fax:!+49:3834:51547:3!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2009!
12!employees!
Private!
Sales!of!enzymes!and!kits!and!contract!research!are!the!main!revenue!
sources.!
Biocatalysis!!
E.,coli,
Small!quantities!offered,!bulk!amounts!by!request!
Ulf!Menyes,!CEO.!
BRAIN!AG!and!Braun!Beteilgungs!GmbH!have!minority!ownerships!interests!
in!the!company.!!Along!with!a!third!partner,!Herbrand,!these!entities!enable!
Enzymicals!to!access!a!broad!range!of!technologies!from!screening!
metagenomic!DNA!libraries!to!biocatalysis!process!development.!
NA!
NA!
++!
+!
Enzymicals!is!primarily!a!service!provider!offering!screening!of!a!selection!of!existing!enzymes,!synthetic!
expertise!for!using!enzymes!as!biocatalysts,!and!enzyme!customization!using!directed!evolution!and!
semi:rational!mutagenesis.!!The!company!also!offers!a!catalog!of!enzymes!and!enzyme!kits.!!!
Products:!
8!(R):selective!transaminases!(licensed!from!Lonza,!June!2011)!
6!bacterial!Baeyer:Villiger!Monooxygenases!
!
215!
!
!
!!
6!isozymes!of!pig!liver!esterase!(exclusive!license!from!Evonik,!October!2010)!
1!amino!acylase!
10!bacterial!esterases!
These!enzymes!are!available!individually!and!in!kits.!
!
!
'
'
!
216!
!
!
!!
Enzymology'Research'Center,'Inc'
http://www.ercenzymes.com/!!
206!West!Street!North!
Miltona,!MN!56354!
USA!
Tel:!+1:218:943:9127!
Fax:!+1:218:943:9128!
Tel:!+1:888:661:1100!
Fax:!+1:888:677:1100!
Emails:[email protected];[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Contract!Manufacturing!
!
1995!
about!11:50!employees!
Private!
Enzymes!sales!are!nearly!all!revenues.!
Neutraceuticals!
NA!
10,000!sq.!ft.!manufacturing!facility!
Troy!Aupperle,!Founder!and!CEO!
NA!
NA!
NA!
+!
++!(GMP!compliant)!
From!the!company!website:!“ERC!is!a!leading!contract!manufacturer!that!specializes!in!enzymes!and!
enzyme:based!products.!Our!facilities!operate!under!strict!Good!Manufacturing!Practices!
(GMP’s)(2009)”!
Products:!
Chymotrypsin,!Pancreatin,!Pancrelipase,!Pepsin,!Trypsin!
!
'
'
!
217!
!
!
!!
Enzyvia'LLC'
www.enzyvia.com!!
214!South!Main!Street!
Sheridan,!IN!46069!!
USA!
Tel:!+1:800.497.5580!
Fax:!+1:317.758.2697!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
501:1000!employees!(parent!company)!
Private,!subsidiary!of!JBS!United.!
Animal!feed.!
Two!undisclosed!fungal!strains!
Bulk.!!In:house!manufacturing.!
NA!
NA!
NA!
NA!
+!
:!
From!a!press!release:!“Enzyvia!LLC!is!a!global!company!based!in!Sheridan,!IN!that!researches,!develops!
and!commercialized!value!added!feed!additives!for!animal!production!and!improvement.!Enzyvia!LLC!is!
a!wholly!owned!subsidiary!of!JBS!United!which!is!a!leading!global!agricultural!products!company!based!
in!Sheridan,!Indiana.!Since!its!founding!in!1956,!JBS!United!has!been!dedicated!to!providing!research:
based!solutions!to!enhance!animal!nutrition!and!livestock!production!profitability.!The!company!
provides!various!products!and!services!to!swine,!dairy!cattle,!poultry!and!other!animal!producers!
worldwide.”!
Products:!
Enzyme!mixture!formulation!consisting!of!carbohydrate!hydrolases.!
!
'
'
!
218!
!
!
!!
EpiCentre'Biotechnologies'
http://www.epibio.com/!!
5602!Research!Park!Blvd.,!Suite!200!
Madison,!WI!53719!!
USA!
Tel:!+1:800:284:8474!!
Tel:!+1:608:258:3080!!
Fax:!+1:608:258:3088!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1987!
51:200!employees!
Private,!owned!by!the!public!company!Illumina!
Significant!portion!of!revenues!derived!from!enzymes.!
Life!science!enzymes,!molecular!biology.!
E.,coli,!likely!others!
Bulk.!!In:house!production!
NA!
NA!
NA!
+++!
++!
+++!
From!the!company!website:!“Epicentre®!Biotechnologies,!founded!in!1987,!uses!its!expertise!in!enzyme!
manufacturing!to!produce!innovative!kits!for!life!science!research.!The!kits!and!reagents!manufactured!
by!Epicentre!contribute!to!breakthrough!studies!in!genomics!and!transcriptomics.!Products!are!available!
for!DNA!and!RNA!sequencing,!gene!expression!analysis,!DNA!and!RNA!purification,!PCR!and!RT:PCR,!
cloning,!in!vitro!transcription,!and!microbial!genomics.”!
Products:!
DNA!and!RNA!Polymerases!
!
219!
!
!
!!
Ligases!
Deadenylase!
Glucosyltransferase!
Lysozyme!
Glycosylases!
Phosphatases!
Kinases!
!
!
!
'
'
!
220!
!
!
!!
Epygen'Labs'FZ'LLC'
www.epygen.com!!
PBU!WH!Block!D21:D22!
DUBIOTECH!Park!
Umm!Suqeim!Road!
PO!Box!485018!Dubai!
United!Arab!Emirates!
Tel:!+971!4!457!2850!
Fax:!+971!4!457!2961!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
11:50!employees!
Private!
Enzymes!are!a!significant!source!of!revenues,!though!the!company!seems!to!
be!emphasizing!therapeutic!protein!capabilities!going!forward.!
Oil!field!applications,!biomass!conversion,!pulp!and!paper,!textiles!and!
detergnets,!food!and!feed,!leather.!!
Bacillus,subtilis,,Trichoderma,!others.!
Bulk!
Debayan!Ghosh,!Co:Founder!and!President;!Ariyarathenam!Manickam,!Co:
Founder!
Partnered!with!Saudi!Aramco!to!test!its!oil!field!enzymes.!
Global!
NA!
++!
:!
Epygen!is!a!producer!and!supplier!of!industrial!enzymes.!!The!company!has!research!and/or!
manufacturing!capabilities!in!the!USA,!United!Arab!Emirates,!and!India.!!A!new!plant!in!India!is!designed!
for!purposes!including!therapeutic!protein!production,!and!Epygen!has!recently!been!emphasizing!the!
potential!of!enzymes!and!other!proteins!for!cardiovascular!health.!!!
Products:!
Cellulases!
!
221!
!
!
!!
Mannase!
Alpha:amylases!
Proteases!
Hemicellulases!
Phytase!
Xylanase!
Lipases!
Pectinase!
Tannase!
Glutaminases!
Catalase!
Laccase!
!
!
!
222!
!
!
!!
ERA'Biotech'
http://www.erabiotech.com/!!
Calle!Baldiri!i!Reixach,!nº!15!:!21!!
08028!Barcelona!
Spain!
Tel:!+34!93!403!47!73!!
Fax:!+34!93!403!47!72!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
32!employees!
Private!
NA!
NA!
Custom!Zera!peptide!platform!for!high:protein!expression.!!Works!in!insect!
and!mammalian!cells!as!well!as!fungal!hosts.!
Small!
Miriam!Bastida,!Managing!Director!(CEO)!
NA!
NA!
++!(funded!by!venture!groups!and!government!grants)!
NA!
++!(offers!a!custom!platform!for!high!protein!expression)!
ERA!Biotech!is!based!around!a!technology!to!highly!express!proteins!attached!to!a!linker!that!can!then!
be!easily!purified.!!!
'
'
!
223!
!
!
!!
Erbslöh'Geisenheim'AG'
http://www.erbsloeh.com/!!
Erbslöhstraße!1!
65366!Geisenheim!
Germany!
Tel:!+49!6722!708:0!
Fax:!+49!6722!6098!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Over!100!years!old!
130!employees!
Relatively!small!
Enzymes!for!alcoholic!and!non:alcoholic!beverage!production.!
Likely!Aspergillus!and!Bacillus!
Managing!Directors:!Dietmar!Hemmert,!!Jörg!Möller!
La!Littorale!in!France!is!a!wholly:owned!subsidiary.!!Sells!through!Greatown!
International!Co.,!LTD!in!China,!!
Sells!globally.!
+++!(estimated)!
++!
:!
Erbslöh!supplies!enzymes,!yeasts,!and!other!additives!and!fermentation!enhancers!to!producers!of!
juices!and!alcoholic!beverages!including!wine,!beer,!and!spirits.!!
Products:!
Pectinases!
Alpha:amylases!
Beta:glucanases!
Xylanases!
Glucoamylase'
!
!
224!
!
!
!!
Eucodis'Bioscience'GmbH'
http://www.eucodis.com/!!
Campus!Vienna!Biocenter!II!
Viehmarktgasse!2!a/!2.!OG!
1030!Vienna!
Austria!
Tel:!+!43!1!8900804!
Fax:!+43!1!8900804!ext.!11!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
11:50!employees!
Private!
As!of!early!2013,!enzyme!and!protein!engineering!services!make!up!about!
65%!of!Eucodis’!revenues.!
Biocatalysis!
E.,coli,,Bacillus,subtilis,,Pichia,pastoris,
Eucodis!can!produce!proteins!on!up!to!the!kg!scale!using!fermentations!of!up!
to!1000!L!
Karl!Hübler,!CEO;!Jan!Modregger,!Head!of!R!&!D!
Eucodis!and!Evocatal!co:marketed!products!in!the!past,!but!this!agreement!is!
thought!to!no!longer!be!active.!!
Eucodis!lists!the!following!companies!as!customers:!Dr.!Reddy’s,!Genencor,!
Genzyme,!GSK,!Henkel,!Lohmann!Animal!Health,!Roche,!Sandoz,!and!Sigma:
Aldrich.!
NA!
+!
++!
Eucodis!was!originally!founded!to!apply!proprietary!in!vivo!recombination!and!somatic!hypermutation!
methods!to!both!the!chemical!biotechnology!and!the!pharmaceuticals!markets.!!In!2007,!the!company!
dropped!the!focus!on!pharmaceuticals.!!However,!the!company!recently!undertook!a!major!effort!on!
pharmaceutical!antibody!drug!conjugates,!called!CTAT!(C:Terminal!amidotransferase).!!Since!2009,!the!
company!has!been!offering!a!catalog!of!enzymes!for!purchase,!and!enzyme!kits.!!The!company!has!a!
focus!on!lipases,!but!also!offers!other!enzymes.!!!Eucodis’!first!product!was!LacBusterTM,!which!is!a!
!
225!
!
!
!!
brand!of!beta:lactamases!first!offered!in!2010.!!The!company!offers!custom!manufacturing,!and!is!
experienced!in!fermentation!development,!downstream!processing,!and!protein!characterization.!
Products:!
Lipases!(more!than!20!proprietary!enzymes)!
Lac:Buster!(broad:range!beta:lactamase)!
Kit!of!more!than!20!lipases!
Phospholipases!
Nitrile!hydratase!
Hydroxynitrilases!
Transaminases!
'
'
!
226!
!
!
!!
evocatal'Gmbh'
http://www.evocatal.com/!!
Alfred:Nobel:Strasse!10!
40789!Monheim!am!Rhein!
Germany!
Tel:!+49!(0)2173:40994:0!
Fax:!+49!(0)2173:40994:40!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
21!employees!
Private!
Major!revenues!are!probably!collaborative!research;!enzymes!likely!make!up!
a!minority!portion!of!revenues.!
Biocatalysis!
In:house!tailored!strains!of!E.,coli!and!Bacillus,subtilis!
Though!it!has!fermentation!expertise,!the!company!appears!to!have!limited!
scale!up!abilities!in!house,!and!it!works!with!partners!to!produce!larger!
amounts!of!enzyme.!
Thorsten!Eggert,!CEO!and!Founder;!Michael!Puls,!Business!Development;!
Thomas!Daussmann,!Adivsor!
Evocatal!has!established!partnerships!with!a!number!of!high:profile!
companies!including!Henke,!Sartorius,!Lanxess,!Symrise,!Digital!Specialty!
Chemicals,!Rohner!Chem,!Eucodis!Bioscience,!m2p!labs,!and!artes.!!Eucodis!
and!Evocatal!announced!a!co:marketing!agreement,!but!it!is!thought!to!
noloonger!bne!active.!
NA!
NA!
++!
NA!
Evocatal!was!spun:off!from!the!Institute!of!Molecular!Enzyme!Technology,!Heinrich:Heine:University!of!
Düsseldorf.!!The!company!sells!both!products!and!services.!!The!products!include!off!the!shelf!
biocatalysts,!chiral!compounds,!a!set!of!73!chaperone!proteins!from!different!organisms,!and!a!family!of!
fluorescent!proteins!called!everglow!that!function!in!both!aerobically!and!anaerobically!grown!cells.!!The!
services!include!enzyme!identification!in!the!company’s!metagenomic!DNA!libraries!of!unculturable!
!
227!
!
!
!!
organisms!recombinantly!expressed,!and!directed!evolution!to!optimize!the!enzymes!to!meet!process!
demands.!!!
Evocatal!moved!in!late!2o013!to!a!new!site!in!Monheim!am!Rhein,!gainng!larger!space!and!room!for!
further!expansion.!The!move!came!about!in!conjunction!with!a!EUR!3.5!million!equity!investment!
completed!in!June!2013.!Cologne:based!chemical!company!Lanxess!participated!in!this!financing.!
Products:!
TPP:enzymes!
Ketoreductases!
Transaminases!
Lipases!
Hydroxynitrile!lyases!
Cofactor!regeneration!enzymes!!
Kit!6!transaminases!
Kit!of!19!lipases!
Kit!of!12!alcohol!dehydrogenases!and!ketoreductases!
Kit!of!7!TPP!enzymes!
!
'
'
!
228!
!
!
!!
Fenkim'
http://www.fenkim.com/!!
BARBAROS!BULVARI!YILDIZ!APT.!NO!69/3!
34353!BESIKTAS!–!ISTANBUL!!
Turkey!
Tel:!+90!212!227!50!47!
Fax:!+90!212!227!52!64!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
5:10!employees!
Private!
Major!part!of!revenues!
Textiles!!!
NA!
NA!
NA!
NA!
NA!
+!
:!
From!the!company!website:!“Fenkim!Kimya!Sanayi!Ve!Ticaret!limited!sirketi!started!its!business!in!2002!
as!textile!enzyme!distributor.!Currently,!Fenkim!deals!with!trade!of!textile!enzymes!and!all!kinds!of!
textile!products!(i.!E.!Towel,!lingerie)!worldwide.!Our!mission!is!to!share!our!experience!in!textile!
industry!with!our!precious!customers.”!
Products:!
Alpha:amylases!
Cellulase!
Lipase,!Protease!
Mannase'
!
!
229!
!
!
!!
Fermenta'Biotech'Ltd'
http://www.fermentabiotech.com/!!
'dil'!complex,!Ghodbunder!Road!
Majiwada,Thane!(West)!!
400!610,!Maharashtra!
India!
Tel:!+91!22!6798!0888!!
Fax:!+91!22!6798!0999!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1986!
201:500!employees!
Private!
Penicillin!G!Amidase,!Penicillin!G!Acylase,!Cal!B!Lipase,!Candida,Antarctica!
Lipase!B,!Enzyme!Immobilization!
NA!
Bulk!
Prashant!Nagre,!Chief!Executive!Officer!
Fermenta!supplies!its!immobilization!material!to!Chiral!Vision!
Global!
++!(steadily!growing!profits)!
+!
+!(immobilization!platform)!
Fermenta!is!a!major!producer!of!vitamin!D3!and!of!enzymes!for!the!synthesis!of!penicillin!and!
cephalosporin!antibiotics.!The!company!also!produces!two!lipases,!beads!for!enzyme!immobilization,!
and!immobilized!enzymes.!!In!addition,!the!company!has!a!division!called!environmental!solutions!that!
provides!information,!services,!and!products!for!lake!remediation,!waste!water,!and!solid!waste.!!!
Products:!Immobilized!and!soluble!versions!of!
Penicillin!G!Amidase!(Penicillin!G!Acylase)!
Cal!B!Lipase!(Candida,antarctica!Lipase!B)!
!
230!
!
!
!!
Fermentia'
http://www.fermentia.eu/!!
Berlini!utca!47:49!
H:1045!Budapest!
Hungary!
Tel:!+36:30:3502847!
Fax:!+36:1:3696024!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
12!employees!
Private!
Very!small,!mostly!a!service!provider.!
Immobilized!lipases!
GMO!and!non:GMO!
Up!to!1000!L!fermenations!
Balázs!Erdélyi!,!Operating!manager!(CEO)!and!Founder!
Several!undisclosed,!SynBiocat!Ltd.!
Axis:Shield!Ltd,!BactoFil,!others!undisclosed.!
Not!indicated,!but!the!company!has!been!growing.!
+!(a!small!selection!of!immobilized!lipases!is!offered!in!partnership!with!
SynBiocat!Ltd.)!
++!(CMO)!
Fermentia!is!a!custom!manufacturing!organization!in!Hungary!that!specializes!broadly!in!fermentation.!!
It!produces!enzymes,!proteins,!DNA,!small!molecules,!and!other!fermentation!products.!!It!has!a!
partnership!with!a!small!startup!called!SynBiocat!to!manufacture!immobilized!lipases,!and!it!lists!these!
lipases!as!products!on!its!website.!!These!lipases!are!the!only!products!that!Fermentia!offers,!and!its!
business!is!almost!exclusively!contract!manufacturing.!
Products:!
Immobilzed!lipases!(6,!available!individually!or!as!a!kit)!
!
'
'
!
231!
!
!
!!
Fytozimus'Biotech'Inc.'
http://www.fytozimus.com/!!
Edmonton,!Alberta! T5J!2G1!
Canada!
Tel:!+1:780:476:9099!
Tel:!+1:866:476:9099!
Fax:!+1:780:475:6757!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
10:20!employees!
Private!
Most!to!all!sales!are!enzymes!
Dairy!enzymes,!proteases!plant!sources!for!cheese!making!without!animal:
derived!enzymes.!
Extraction!from!plant!material.!
Maria!Salomé!Pais,!Founder!&!CEO!
Enzyme!Development!Corp!
Through!partners!Enzyme!Development!Corp!sells!its!protease!enzyme!in!the!
USA!
NA!
+!
:!
From!the!company!website:!“Fytozimus!Biotech!Inc.,!founded!by!Dr.!Maria!Salomé!Pais,!was!formed!to!
meet!dairy!manufacturers'!needs!for!a!more!natural,!flexible!and!environmentally!conscious!approach!to!
the!creation!of!their!products.!!With!its!corporated!headquarters!located!in!the!economically!strong!
region!of!Edmonton,!Alberta,!Canada!and!its!research!offices!in!historic!Lisbon,!Portugal,!Fytozimus!is!
well!positioned!to!expand!globally.!!Fytozimus'!plant:based!products!offer!the!potential!to!create!
cheeses!with!new!and!exotic!textures!and!aromas,!in!a!highly!competitive!and!demanding!market.”!
Products:!
Proteases!
'
'
!
232!
!
!
!!
Galilaeus'Oy'
http://www.galilaeus.fi/!!
Rakentajantie!26!
20780!Kaarina!
Finland!
Tel:!+358:20!7218!460!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1994!
51:200!
Private!
Only!through!contract!manufacturing.!
NA!
Primarily!E.,coli,!also!experienced!with!Streptomyces,!fungi!and!yeasts.!
Fermentation!capacity!from!2!L!up!to!15,000!L.!!Production!runs!take!place!at!
the!company’s!plant!in!Poland.!
NA!
NA!
NA!
NA!
:!
+++!
From!the!company!website:!“Galilaeus!is!specialized!in!fermentative!manufacturing!with!microbes!in!
three!business!lines:!APIs,!Biocatalysts!and!Nutraceuticals.!!Galilaeus!Oy!is!one!of!the!leading!contract!
manufacturers!in!the!biotech!field,!and!we!have!the!largest!fermenter!unit!in!Europe.!Galilaeus!offers!its!
clients!flexible,!varied!service!packages!together!with!co:operation!producing!added!value!to!our!
customers.”!!!
!
'
'
!
233!
!
!
!!
Genkim'
www.genkim.com.tr!!
BURSA!Organize!Sanayi!Bölgesi!Lacivert!Cadde!2!
Sokak!No:!Nilüfer!
BURSA!
Turkey!
Tel:!+90!224!241!7780!
Fax:!+90!224!241!7784!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
About!1986!
Small!
Private!
Small!
Textile!enzymes!
NA!
Bulk,!likely!no!in:house!production!
Ali!Suavi!Kuter,!General!Manager!
NA!
NA!
NA!
+!
:!
Genkim!is!a!textile!chemical!supplier.!
Products:!
Catalase!
Cellulase!
Alpha:amylase!
!
!
!
234!
!
!
!!
GenScript'USA,'Inc.'
http://www.genscript.com/!!
860!Centennial!Ave.!
Piscataway,!NJ!08854!
USA!
Tel:!+1:877:436:7274!
Tel:!+1:732:885:9188!
Fax:!+1:732:210:0262,!+1:732:885:5878!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
!!
2002!
1,200!employees!
Private!
Small!
Life!science!enzymes.!
Multiple!
Up!to!300!g!scale.!!In:house.!
NA!
NA!
NA!
NA!
+!
+!
Founded!in!2002,!GenScript!is!an!international!provider!of!biology!products!and!services.!!These!are!
grouped!into!four!main!areas:!Bio:Reagent,!Bio:Assay,!Lead!Optimization,!and!Antibody!Drug!
Development.!!The!company!offers!custom!protein!expression!and!purification.!!
Products:!
Proteinase!K!
Enterokinase!
Streptokinase,!Proteases!
!
235!
!
!
!!
GNC'Bioferm'Inc'
www.gncbioferm.ca!!
1221!Wilder!Road!
Cobble!Hill,!B.C.!V0R!1L0!
Canada!!
Tel:!+1:250:743:7850!!
Fax:!+1:250:743:7860!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1985!
Small!to!medium!
Private!
Most!to!all!
Animal!feed!enzymes!
Aspergillus!(non:GMO)!
Multi:ton.!!In:house!manufacture.!
NA!
Sells!enzymes!via!distributors!including!major!partner!Andres!Pintaluba.!
Global!
NA!
+!
:!
GNC!Bioferm!manufactures!two!enzyme!product!mixtures!for!animal!feed!applications.!!The!target!
animals!are!pigs!and!poultry.!
Products:!
Two!enzyme!mixtures!branded!Endofeed!and!Amylofeed!that!include:!
Beta:glucanase!
Xylanase!
!
'
'
!
236!
!
!
!!
Habio'Bioengineering'(Sichuan)'
http://www.habio.net!!
Tangxum!Town,!Fucheng!District!
Mianyang!
Sichuan!P.C.!621000!
China!
Tel:!+86!28!8557!2969! !
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Mobile:!+86!13880!252!909!!
2002!
Annual!Sales!approximately!US$!10!million;!>170!employees,!>20!in!R!&!D!
Private!
Animal!feed,!food!and!industrial;!lipase!for!biodiesel!production!
15!different!production!strains!
Mr.!Tao!Yang,!CEO;!Justine!Tong,!Head!of!Sales!and!Marketing!
Partnerships!Cargill,!Kemin,!Samsung!
China!and!Global,!selling!in!30!countries!
++!
++!
+!will!discuss!on!request!
From!the!web!site:!“Habio!focuses!on!research!and!application!of!enzymes!in!feed!industry,!and!makes!a!
long:term!commitment!in!promoting!and!practicing!high!efficient!solutions!of!developing!feed!resources!
and!improving!feed!efficiency.!Habio!has!leading!producing!and!supplying!capability!for!bio:
fermentation!products!in!Asia.!The!bio:fermentation!production!industrial!manufactory!has!been!
finished!so!far!with!total!investment!100!million!RMB!and!fermentation!capability!over!15,000!MT!per!
year.”!
Products:!Habio!Bioengineering!offers!the!following!enzymes!in!food,!feed,!and!industrial!grades.!The!
company!also!offers!formulations!of!multiple!enzymes!for!poultry,!livestock,!ruminant,!egg:layers,!also!
special!formulations!for!pigs!at!different!stages!of!growth.!
Products:!
Lipases,!including!Lipozyme!for!feed!and!Habio!Lipase!for!biodiesel!production!
!
237!
!
!
!!
Catalase!
Phytase!
Xylanase!
Galactosidase!
Beta:Mannanase!
Beta:Glucanase!
Amylases!
Proteases!
Cellulase!
Pectinase!
'
'
!
238!
!
!
!!
Huvepharma'
5th!floor!
3a!Nikolay!Haytov!Str.!
Sofia,!1113!
Bulgaria!
Tel:!+359!2!862!53!31,!868!20!95!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1954!
1000+!employees!
Private,!part!owned!by!Citigroup!
Animal!feed!and!food.!
Trichoderma,!others!not!disclosed!
Bulk.!!In:house!manufacturing!via!subsidiary!Biovet.!
Kiril!Domuschiev,!President!
Huvepharma!is!the!majority!owner!of!Biovet!
Global!
++!
+!
:!
From!a!press!release:!“Huvepharma®!is!a!privately!owned,!globally!operating!animal!health!and!nutrition!
company!that!brands!a!broad!portfolio!of!products!used!in!the!swine,!poultry!and!cattle!production.!The!
company!is!committed!to!develop,!manufacture,!service!and!market!animal!health!and!feed!additive!
products!that!provide!economical!solutions!for!customers.!Huvepharma!has!manufacturing!facilities!as!
well!as!sales!and!marketing!organizations!around!the!globe!which!establish!direct!relationships!with!
intensive!livestock!customers.”!
Products:!
The!company!offers!about!15:20!formulations!consisting!of!the!following!enzymes:!
Beta:glucanases!
Xylanases!
Cellulases!
!
239!
!
!
!!
Hemicellulase!
Lipases!
Alpha:amylases!
Phytase!
Pectinase!
!
!
!
!
'
'
!
240!
!
!
!!
IBEX'Technologies,'Inc.'
http://www.ibex.ca/!!
5485!Pare!Street,!Suite!100!
Montreal,!Quebec,!H4P!1P7!
Canada!
Tel:!514:344:4004!
Fax:!514:344:8827!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1972!
11:50!employees!
Public:!IBT!
Major!portion!of!revenues!
Recombinant!high:purity!proprietary!enzymes!(heparinases!and!
chondroitinases)!
Flavobacterium,heparinum!
grams!to!kgs!
Paul!Baehr,!President!and!CEO!
NA!
NA!
++!
+!(small!but!rare!offerings)!
:!
From!the!most!recent!financial!report:!“The!Company,!through!its!wholly!owned!subsidiaries,!IBEX!
Pharmaceuticals!Inc.!(Montreal,!QC)!and!Bio:Research!Products!Inc.!(North!Liberty,!IA),!manufactures!
and!markets!enzymes!for!biomedical!use.!IBEX!also!manufactures!and!markets!a!series!of!arthritis!assays!
which!are!widely!used!in!osteoarthritis!research.”!
Products:!
Heparinases!
Chondroitinases!
'
'
!
241!
!
!
!!
Imperial'Jade'BioBTechnology'Co.,'Ltd.'
imperialjade12.en.china.cn!!
China!
Tel:!+86:951:13619572664!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
11:50!employees!
Private!
Most!revenues!from!enzyme!sales!
Food,!feed,!leather.!
Trichoderma,,Candida,lipolytica,,Aspergillus,,Bacillus,licheniformis,,Bacillus,
subtilis!
NA!
NA!
Global!
NA!
+!
:!
Imperial!Jade!is!a!Chinese!company!that!probably!mostly!serves!the!Chinese!markets.!!Its!enzymes!have!
appeared!in!at!least!two!peer:reviewed!publications.!
Products:!
Pectinase!
Lipase!
Proteases!
Xylanase!
Cellulase!
!
!
'
'
!
242!
!
!
!!
Infinite'Enzymes'
www.infiniteenzymes.com!!
PO!Box!2654!!!!!!!!
State!University,!AR!!72467!!!!!!
USA!!
Tel:!+1:870:926:9566!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
1:10!employees!
Private!
Revenues!from!government!grants!probably!dominate,!but!some!revenues!
are!derived!from!enzyme!product!sales.!
Cellulose:degrading!enzymes.!!First!product!is!IE:CBHI!or!Cellobiohydrolase!I!
(Cel6A;!E.C.3.2.1.91)!from!Hypocrea,jecorina.!
Corn!seed!expression!platform.!
NA!
Elizabeth!Hood,!CEO!
IE:CBHI!is!available!through!Sigma:Aldrich.!!Other!partners!are!Arkansas!
State!University,!Arkansas!Science!and!Technology!Authority,!Memphis!
Bioworks!Foundation.!!Manufacturing!appears!to!be!done!at!Applied!
Biotechnology!Institute.!!BioDimensions!is!an!investor.!
NA!
+!(estimated,!based!on!current!government!grant,!and!start!of!product!sales)!
+!(one!enzyme)!
:!
From!the!company!website:!“Infinite!Enzymes!is!a!biotech!company!with!a!novel!genetic!technology!for!
producing!low:cost,!plant:based!enzymes!for!converting!cellulosic!biomass!into!biofuels!and!other!
biobased!products.!Infinite!Enzymes’!plant!genetic!technology!enables!the!production!of!cellulase!
enzymes!in!the!embryo!(germ)!of!the!corn!kernel.!Using!transgenic!corn!as!a!“plant!factory”!for!
producing!cellulase!enzymes,!Infinite!Enzymes!can!deliver!high:quality,!cost:competitive!cellulase!
enzymes!on!a!commercial!scale!without!the!capital!intensive!requirements!and!environmental!costs!
associated!with!existing!enzyme!production!through!microbial/fungal!fermentation!processes.”!!!
Products:!
Cellobiohydrolase!I!
!
243!
!
!
!!
InnoTech'MSU'
Web:!http://www.innotech:msu.com!!
Innovations!and!High!Technologies!MSU!Ltd.!
Tsymlyanskaya!ul.,!build!16,!office!96!
109559!Moscow!
Russia!
Tel:!+7(495)939!32!08!
Fax:!+7(495)939!27!42!
E:mail:[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
Small!
Private!
Likely!significant!
Biocatalysis!and!diagnostics.!
All!products!recombinant!in!E.,coli!!
Likely!small,!in:house!production.!
Vladimir!Ivanovich!Tishkov,!Professor,!Head!of!the!Laboratory!of!Genetic!
Engineering!and!Protein!Design!:!Faculty!of!Chemistry!,!M.V.Lomonosov!
Moscow!State!University,!Moscow,!Russian!Federation!
NA!
NA!
NA!
+!(small!selection!of!possibly!unique!enzymes)!
NA!
Billed!as!a!“Recombinant!Enzymes!Specialist.”!Founded!around!work!from!Moscow!State!University.!
Anastasiya!Stepashkina!and!other!employees!presented!at!the!Russian!“Biocatalysis:2013”!conference.!!!
Products:!
Peroxidase!from!horseradish,!Peroxidase!from!tobacco!
Formate!Dehydrogenases!(2,!thermostable):!One!NAD+!specific;!one!NADP+!specific!!
D:Amino!acid!oxidase'
!
!
244!
!
!
!!
Iris'Biotech'GmbH'
http://www.iris:biotech.de/!!
Waldershofer!Str.!49:51!!
D:95615!Marktredwitz!!
Germany!!
Tel:!+49:9231:9619:73!!
Fax:!+49:9231:9619:99!!
Email:!info@iris:biotech.de!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2001!
11:50!employees!
Private!
Small!
Biocatalysis!!!
LIkely!does!not!manufacture!in!house.!
Some!enzymes!available!in!up!to!multi:Kg!quantities.!!!
Oskar!Tropitzsch,!Managing!Director!(CEO)!
Partnership!with!SPRIN!SpA!for!immobilization!of!enzymes.!!Works!with!
around!35!suppliers!for!many!of!its!products.!
NA!
NA!
+++!
:!
Iris!Biotech!is!a!distributor!of!enzymes!from!variuous!sources,!with!a!focus!on!the!biocatalysis!and!
research!markets.!
From!the!company!website:!“IRIS!Biotech!is!specialized!in!reagents!for!Peptide!Synthesis,!PEGylation,!
Life!Science!Research!and!Biocatalysis.!We!have!specific!know:how!and!production!capabilities!to!
manufacture!and!supply!products…from!grams!to!multi:ton!lots.”!
Products:!
Immobilized!and!soluble!enzymes!in!kits!or!individually!including:!
Lipases!
!
245!
!
!
!!
Hydroxynitrile!lyases!
Inulinase!
D:hydantoinase!
Carbamoylase!!
Penicillin!G!amidase!
Collagenase!
Peroxidase!
Nitroreductase!
Phytase!
Tannase!
Esterases!
Proteases!
Amylases!
Cellulase!
Chloroperoxidase!
Laccase!
Lactase!!
Alcohol!oxidase!
Amidase!
Cytochrome!P450s!
Ene!reductases!
Epoxide!hydrolases!
Formate!dehydrogenase!
Ketoreductases!
!
246!
!
!
!!
Transaminases!
Nitrilases'
'
!
247!
!
!
!!
JenaBioScience'GmbH!
http://www.jenabioscience.com!!
Löbstedter!Str.!78!
07749!Jena!
Germany!
Tel:!+49:3641:46!49!52!
Fax:!+49:3641:46!49!91!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1998!
ca.!35!employees!
Private!
Small!!
Molecular!biology!and!life!sciences!
NA!
mg!to!Kg!scale.!!Some!in:house!production!likely.!
Mathias!Grün,!CEO!and!Co:Founder!
NA!
NA!
++!(estimation!based!on!business!model!and!growth)!
++!(w/comment)!
:!
From!the!website:!“Jena!Bioscience!serves!three!major!client!groups:!!Research!laboratories!at!
universities,!industry,!government,!hospitals!and!medical!schools;!Pharmaceutical!industry!in!the!
process!from!lead!discovery!through!to!pre:clinical!stages;!and!Laboratory!&!diagnostic!reagent!kit!
producers!and!re:sellers.!!Jena!Bioscience’s!products!include!nucleosides,!nucleotides!and!their!non:
natural!analogs,!recombinant!proteins!&!protein!production!systems,!reagents!for!the!crystallization!of!
biological!macromolecules!and!tailor:made!solutions!for!molecular!biology!and!biochemistry.!“!
Products:!
Restriction!Enzymes,!DNA!and!RNA!Polymerases,!Ligases!
Phosphatases!,!Kinases,!Nucleases!
Topoisomerases!
!
248!
!
!
!!
Jiangsu'Boli'Bioproducts'Co.'Ltd'
http://www.bolibio.com/!!
93!Yangzhou!Road!
Jiangyan!Economic!Development!Zone!
Jiangsu!Province!
PR!China!
Tel:!+86:151!5221!3005!
Fax:!+86:(0)523:8207:8002!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1998!
Probably!50!or!more!employees.!
Private!
Applications!in!fuel!ethanol!production,!grain!processing,!food!baking,!
brewing,!textiles!and!animal!feed.!!!
NA!
30,000!metric!tons!annual!in:house!production!
NA!
NA!
NA!
NA!
++!
:!
From!the!website:!“Boli!Bioproduct’s!enzyme!products!can!be!divided!into!Technical!Grade!and!Food!
Grade,!and!are!available!in!both!liquid!and!solid!(powder)!forms.!!Among!the!many!varied!applications!
for!these!enzymes!are:!!starch!processing,!animal!and!plant!hydrolysis,!baking,!and!the!production!of!
food!and!beverages,!feed,!fuel!ethanol,!textiles,!and!paper.”!
Products:!
Glucoamylase,!Alpha:amylase,!Beta:glucanase,!Catalase!
Protease!
!
249!
!
!
!!
Jiangsu'OGO'Biotech'Co.,'Ltd.'
No.17!Kangping!Rd!
Economic!Development!Zone!
LiyangJiangsu,!Liyang,!Jiangsu!
China!
Tel:!+86:0519:87921088!!
Email:!ogo@ogo:biotech.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
101:500!employees!
Private!
Most!to!all!revenues!from!enzyme!sales!
Carbohydrate!hydrolysis.!
NA!
NA!
NA!
NA!
NA!
+!
:!
Enzyme!manufacturer.!!Website!is!only!available!in!Chinese.!
Products:!
Glucoamylase!
Alpha:amylases!
Xylanase!
!
!
'
'
!
250!
!
!
!!
Jinan'Tiantianxiang'Co.,'Ltd.'
http://www.jnttx.com/!!
China!
Tel:!+86:531:87159986!
Fax:!+86:531:87950220!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1998!
NA!
Private!
Substantial!portion!of!revenues!
Animal!nutrition!
NA!
Bulk.!!In:house!production!likely!
NA!
NA!
NA!
NA!
+!
:!
From!the!website:!“Founded!in!1998,!Jinan!Tiantianxiang!Co.,!Ltd.!is!specialized!in!R&D,!production!and!
service!of!feed!additives.!We!can!supply!feed!enzymes,!feed!flavors!and!other!feed!additives!to!the!feed!
factories!in!China!and!abroad.”!
Products:!
Phytases!
Mannase!
Xylanase!
!
!
'
'
!
251!
!
!
!!
Johnson'Matthey'
http://www.jmcct.com/!!
Orchard!Road,!Royston,!Hertfordshire!
SG8!5HE!!
UK!
Tel:!+44(0)!1763!253000!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1817!
9,700!employees!worldwide!
Public:!JMAT!
Small!
Biocatalysis!
E.,coli,
150!Liter:Fermentation!capacity!
Neil!Carson,!CEO;!Gerard!Compagnoni,!General!Manager,!Catalysis!and!Chiral!
Technologies;!Fred!Hancock,!Technical!Director!Catalysis!and!Chiral!
Technologies!!
NA!
Global!
+++!
+!
:!
In!2010,!Johnson!Matthey!entered!the!enzyme!market!through!its!acquisition!of!German!company!X:
Zymes.!!X:Zymes!was!founded!in!2001!as!a!spin!out!from!Heinrich:Heine:University!in!Dusseldorf.!!The!
company!was!small,!with!about!8!employees,!and!it!made!variants!of!enzymes!for!use!as!biocatatalyst!in!
the!pharma!indusry.!!!The!enzymes!from!X:Zymes!are!now!offered!for!sale!through!Johnson!Matthey,!
and!the!X:Zymes!name!is!no!longer!used.!!Johnson!Matthey!offers!a!range!of!enzyme!for!biocatalysis!
rsearch!and!manufacturing,!and!also!offers!contract!screening!and!research!services!in!biocatlaysis.!!!
Sites!for!R!&!D!in!biocatalysis!and!enzyme!development!are!maintained!in!Cambridge,!UK!and!
Duesseldorf,!Germany.!
Products:!!
Sold!individually!and!in!screening!kit!formats:!
!
252!
!
!
!!
Alcohol!dehydrogenases!(ketoreductases)!
Esterases!
Lipases!
Aldehyde!reductases!
Aldehyde!dehydrogenases!
Ene!reductases!
Transaminases!
NAD(P)!cofactor!regeneration!enzymes!
!
'
'
!
253!
!
!
!!
Kemikalia'AB'
www.kemikalia.se!!
LILLA!VÄSTERGATAN!1!274!32!SKURUP!
Sweden!
Tel:!+46:411:49750!
Fax:!+46:411:49760!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1914!
15!employees!
Private.!!Subsidiary!of!CH!Trading!GmbH!in!Austria!
Dairy!enzymes!
Extraction!from!animal!tissue,!Kluyveromyces,lactis!
NA!
NA!
EU!
NA!
+!
:!
Kemikalia!specialized!in!ingredients,!chemicals,!and!specialty!products!for!the!dairy!industry.!
Products:!
Chymosin!
Pepsin!
Lipase!
Lysozyme!
Beta:galactosidase!
!
!
!
254!
!
!
!!
Kemin'
www.kemin.com!!
2100!Maury!Street!!
Des!Moines,!IA!50309!!
USA!
Tel:!+1:515:559:5100!
Tel:!+1:800:777:8307!
Fax:!+1:515:559:5232!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1961!
1600!employees,!$520!million!annual!sales!
Private!
Small!
Animal!feed!enzyme!mixtures!under!the!trade!name!Kemzyme!
NA!
Chris!Nelson,!CEO!
NA!
Global,!offices!in!60!countries.!
+++!
+!
:!
From!website:!“Using!superior!science,!Kemin!manufactures!more!than!500!specialty!ingredients!that!
deliver!important!nutrition!and!health!benefits!through!products!consumed!by!people!and!animals.”!
Products:!
Mixtures!of:!
Amylases!
Pullulanase!
Glucoamylase!
Proteases!
!
255!
!
!
!!
Pectinase!
Xylanase!
Cellulase!
Beta:glucanase'
!
!
256!
!
!
!!
Kerry'Group/Kerry'Americas'
http://www.kerry.com!!
3400!Millington!Road!Beloit!
Wisconsin!53511!!
USA!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1972!
10,000+!
Public:!KRYAF!
Small!
Food!enzymes!for!baking,!beverages,!and!dairy.!!
NA!
NA!
NA!
Global!
+++!
+!
:!
Kerry!Americas!is!part!of!the!Kerry!Group!which!is!based!in!Ireland.!!The!Kerry!group!is!a!manufacturer!
of!food!ingredients!and!foods.!!!
Products:!
Amylases!
Glucanase!
Xylanase!
Invertase!
Proteases!
Cellulase!
'
'
!
257!
!
!
!!
Kiotechagil'
Manton!Wood!Enterprise!Park!
Worksop!
Notts!
S80!2RS!
UK!
Tel:!+44!(0)!1909!537!387!
Fax:!+44!(0)!1909!478!919!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1996!
£13.0!million!annual!revenue.!
Part!of!Anpario.!!Anpario!is!public!(Ticker:!ANP).!
Animal!nutrition!
Penicillium,funiculosum,
Mike!Corbett,!Managing!Director!(CEO)!
Many!distributors.!
Global!
+++!
+!
:!
From!the!company!website:!“Kiotechagil!supplies!high!performance!natural!feed!additives!to!the!
aquaculture!and!agriculture!markets.!It!brings!together!the!expertise!of!Kiotech!and!Agil!across!the!
three!key!protein!sources!of!poultry,!pig!and!fish.!Kiotechagil!has!a!distribution!network!in!over!50!
countries!and!aims!to!be!the!leading!player!in!supplying!high!performance!natural!feed!additives!:!
enhancing!health,!growth!and!sustainability!in!aquaculture!and!agriculture.”!
Products:!
Kiotechagil!sells!mixtures!of!enzymes!for!pig!and!poultry!under!the!brand!Feedzyme.!!These!mixtures!
contain!Beta:glucanase,!Xylanase,!Phytase'
!
!
258!
!
!
!!
Kiwienzyme.com'Ltd'
PO!Box!48076!
Silverstream!5018!
New!Zealand!
Tel:!+64:4!528!8854!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2005!
Small!
Private!
Meat,!cosmeticals,!human!health,!baking.!
Extraction!from!kiwi!fruit.!
Garrick!Wells,!Director!
NA!
NA!
NA!
+!
:!
The!company!is!based!in!New!Zealand,!as!the!name!suggests.!Kiwienzyme!produces!and!sells!actinidin,!
which!is!a!protease!from!kiwi!fruit.!!!
Products:!
Actinidin!
!
!
!
!
'
'
!
259!
!
!
!!
Lactosan'GmbH'
http://www.lactosan.at/!!
Industriestraße!West!5!
A:8605!Kapfenberg!
Austria!
Tel:!+43!(0)386232602:10!!!!
Fax:!+43!(0)386232602:4!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1989!
50!employees!
Private,!owned!by!Schaumann!since!1994.!
No!off!the!shelf!enzymes,!enzyme!revenues!through!custom!manufacturing.!
None!
Lactic!acid!bacteria,!many!other!organisms!customer!specified!
Multi:ton,!in:house!production.!
Hans:Peter!Lettner,!Technical!Director!
NA!
Codexis!has!used!Lactosan!to!produce!essentially!all!of!their!enzymes!on!
large!scale!
++!(estimated)!
:!
+++!
Lactosan!produces!lactic!acid!bacteria!cultures,!and!conducts!contract!manufacturing!for!these!and!
other!products!including!enzymes!under!GMP!/!cGMP!standards.!!The!company!is!a!contract!
manufacturer!of!enzymes!sold!by!Codexis.!!Company!has!produced!custom!transaminases,!
ketoreductases,!monoamine!oxidases,!many!others.!
!
!
!
'
'
!
260!
!
!
!!
Laffort'
http://www.laffort.com/!!
CS!61!611!
33072!BORDEAUX!CEDEX!15!
France!
Tel:!+33!556!86!53!04!!
Fax:!+33!556!86!30!50!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1895!
Medium!to!large!organization!
Important!minortiy!revenue!stream!
Winemaking!
NA!
NA!
NA!
Global!
NA!
++!
:!
Laffort!supplies!the!wine!industry!with!yeasts,!fermentation!aids,!bacteria,!enzymes,!clarification!and!
stabilization!aids,!enzymes,!tannins,!and!wood!products.!!!
Products:!
Lysozyme!
Pectinases!
Beta:glucanase!
Beta:glucosidase!
'
'
!
261!
!
!
!!
Lallemand'
http://www.lallemand.com/!!
1620!rue!Prefontaine!
Montreal!
Quebec!H1W!2N8!
Canada!
Tel:!+1!514!522!2133!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1915!
1001:5000!
Private!
An!important!minority!of!revenues!are!from!enzymes.!
Winemaking,!brewing,!biofuels,!and!baking.!!!
Mostly!Trichoderma!and!Aspergillus!
NA!
Partnered!with!Mascoma!to!develop!a!GMO!yeast!
Global!
+++!
++!
:!
From!the!company!website:!“Lallemand!Inc.!is!a!privately!owned!company!that!researches,!develops,!
produces!and!markets!yeasts,!bacteria!and!related!products!with!the!aim!of!reproducing,!managing!and!
optimizing!natural!fermentation!processes!in!agri:food!industries.”!!Lallemand’s!business!units!are!
animal!nutrition,!baking,!bio:ingredients,!brewing,!biofuels!&!distilled!spirits,!health!solutions,!
manufacturing!services,!oenology,!pharma,!and!plant!care.!
Products:!
Pectinases!
Beta:glucosidases!
Rhamnosidase!
!
262!
!
!
!!
Apiosidase!
Lysozyme!
Polygalacturonases!
Arabinofuranosidase'
!
!
263!
!
!
!!
LamotheBAbiet'
http://www.lamothe:abiet.com/!!
Z.A.!Actipolis,!avenue!Ferdinand!de!Lesseps!
33610,!CANEJAN!/!BORDEAUX!
France!
Tel:!+33!5!57!77!92!92!
Fax:!+33!5!56!86!40!02!
Email:!contact@lamothe:abiet.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1878!
Large!
Private!
Small!but!important!
Winemaking!
NA!
NA!
The!company!carries!the!Novozymes!family!of!winemaking!enzymes,!and!
also!acquires!their!enzyme!supply!from!Novozymes.!
Global!
NA!
++!
:!
Lamothe:Abiet!offers!a!wide!range!of!consumable!materials!for!winemaking!including!yeasts,!
fermentation!additives,!fining!agents,!stabilizers,!taste!enhancers,!and!wood!products.!
Products:!
Polygalacturonases!
Beta:glucosidases!
Beta:glucanases!
!
'
'
!
264!
!
!
!!
Lanxess'GmbH'
www.lanxess.com!!!
Kennedyplatz!1!
50569!Köln!
Germany!
Tel:!+49!(0)!221!/!8885:0!!
Email:!lanxess:[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!(spun!off!from!Bayer!AG)!
17,000!employees!
Public:!LXS!
Very!small!
Leather!!
NA!
Axel!Heitmann,!CEO!
Lanxess!invested!in!enzyme!company!Evocatal.!!Its!leather!enzymes!were!
developed!in!partnership!with!Novozymes!
Global!
+++!
+!
:!
Lanxess!is!a!manufacturer!of!specialty!chemicals,!plastics,!and!rubber.!!It!has!recently!entered!the!
enzymes!area!by!investing!in!Evocatal,!and!by!developing!and!offering!enzymes!for!leather!processing.!!!!!
Products:!
Peltec!X:Zyme!S!(glucosidase)!!
Peltec!X:zyme!U!(protease)!
!
!
'
'
!
265!
!
!
!!
Larbus's.a.'
http://www.larbus.com/!!
c/!Lorenzo!Gonzalez,!9!bajo.!
28017!–!Madrid!
Spain!
Tel:!+34!91!408!30!68!
Fax:!+34!91!407!86!74!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
About!1988!
NA!
Private!
Significant!portion.!!!
Dairy,!fruit!juice,!meat!processing.!
NA!
NA!
Larbus!distributes!enzymes!and!materials!for!third!parties!and!probably!
makes!nothing!in!house.!!Its!suppliers!include!Verenium!and!DuPont!
Industrial!Biosciences.!
NA!
NA!
++!
:!
From!the!website:!“ARBUS,!S.A.!has!been!more!than!twenty:five!years!operating!in!the![dairy]!sector.!
Throughout!the!time,!it!has!been!consolidating!his!presence!in!this!sector,!and!extending!this!activity!to!
other!sectors!like![meat],!and!more!recently!to!the!sector!of!juices!and!concentrates,!providing!the!
necessary!additives!and!ingredients!for!these!industries.”!
Products:!
Proteases!
Chymosin!
Rennet!
!
266!
!
!
!!
Lysozyme!
Catalase!
Pectinases!
Cellulases!
Glucoamylases!
Amylases!
!
'
'
!
267!
!
!
!!
Lentikats'Biotechnologies'
http://www.lentikats.eu!!
Office!Building!ARGO!
Evropska!846/176a,!160!00!Prague!6!
Czech!Republic!
Tel:!+420!255!710!680!
Fax:!+420!255!710!699!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
11:50!employees!
Private!
NA!
NA!
NA!
Production!scale!capable!of!Kg!amounts!in:house!
Ludek!Karasek,!CEO!
Technology!is!licensed!from!geniaLab!GmbH.!!Partnered!with!Enantis!for!
haloalkane!dehalogenase!project.!!Partnered!a!project!for!wastewater!
treatment!with!BASF.!!!
NA!
++!(estimated!based!on!multiple!partnerships!and!investors,!and!consistent!
progress)!
:!
+!(immobilizes!enzymes!on!contract,!does!not!express!them)!
Lentikats!specializes!in!immobilizing!enzymes!and!microorganisms!in!its!unique!lentil:shaped!polymer!
capsules.!!This!immobilization!typically!gives!the!enzymes!increased!stability.!!The!capsules!are!made!out!
of!non:toxic!poly:vinyl!alcohol!and!are!3:4!mm!in!diameter!and!200:400!µm!thick.!!The!company!targets!
applications!in!pharmaceuticals,!food,!distillery,!and!waste:water!treatment.!!LentiKats!has!a!
manufacturing!plant,!head!offices,!and!research!and!development!lab!space,!suggesting!that!the!
company!has!grown!successfully.!!Several!academic!publications!have!appeared!demonstrating!the!
superiority!of!LentiKats’!immobilized!systems!over!non:immobilized!variants.!!!
!
!
!
268!
!
!
!!
Leveking'Enzymes'
http://www.levekingenzymes.com/!!
112:113,!Bio:!Incubator!Building!2!
Gaoxinzhong!One!Road!!
High!&!New!Technology!
Garden!!!District,!Shenzhen!!
China!
Tel:!+86:755:26031010!ext!804!
Fax:!+86:755:26031910!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2001!
51:200!
Private!
Most!to!all!sales!are!enzymes.!
Animal!feed,!baking,!paper!
NA!
NA!
NA!
LEVEKING!enzyme!are!being!exported!to!over!22!countries,!among!which!are!
Asia!(India,!Singapore,!Thailand,Pakistan,!Korea!,!Vietnam!,Philippines,!
Malaysia,etc.)!South!America(!Brazil,!Argentina,!Peru!…)!
NA!
++!
NA!
From!the!company!website:!“Established!in!2001,!LEVEKING!has!emerged!as!a!best!:known!worldwide!
leader!in!the!field!of!Enzymes!for!Animal!Feed,!Baking!industry!and!Paper!Industry.!Moreover,!Leveking!
is!the!first!enterprise!which!use!Lipase!in!feed!industry!in!China;!it!is!approved!by!Ministry!of!Agriculture!
of!the!People’s!Republic!Of!China!and!obtained!the!product!licence!for!feed!additives!and!the!Product!
Approved!No.:!Feed!Additives(2005)!1861.”!
!
!
269!
!
!
!!
Products:!
Lipases!
Xylanases!
Phytase!
Alpha:amylases!
Mannase!
Transglutaminase!
Protease'
!
!
270!
!
!
!!
LibraGen'
http://www.libragen.com/!!
Bâtiment!Canal!Biotech!1!
3!rue!des!Satellites!
31400!Toulouse!
France!
Tel.:!+33!(0)5!62!19!32!90!
Fax:!+33!(0)5!61!73!27!56!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2001!
15!employees!
Private,!owned!by!cosmetic!firm!Induchem!
Small!
Biocatalysis,!cosmetics!
NA!
Pilot!scale,!grams!to!kgs!
Marie:Joëlle!Gaufrès,!Deputy!CEO!
Libragen!has!formed!past!industrial!partnerships!with!Pierre!Fabre,!
Minakem,!Yves!Rocher,!Yves!Saint!Laurent,!DSM,!and!Sanofi:Aventis.!!!
NA!
NA!
++!
+!(pilot!scale)!
LibraGen!offers!transaminase!and!esterase!enzymes!individually!and!in!kits,!as!well!as!services!as!a!
contract!research!organization.!!The!company!additionally!offers!cosmetical!products!and!chemical!
building!blocks.!!The!services!that!LibraGen!offers!include!the!identification!of!new!enzymes!from!its!
collection!of!metagenomic!DNA,!the!improvement!of!the!enzymes,!process!optimization!using!enzymes,!
and!scale!up!of!the!processes!to!pilot!scale.!!LibraGen!lists!reactions!catalyzed!by!the!following!enzymes!
among!its!capabilities:!transaminases,!esterases,!lipases,!oxidoreductases,!phosphorolases,!
dehydrogenases,!nitrile!hydrolases,!ene!reductases,!and!glycosylation!enzymes.!!!
!
!
!
271!
!
!
!!
Products:!
ChiralamineTM!family!of!25!transaminases!available!in!kits!or!individually!
MEGAesteraseTM!family!of!6!esterases!and!lipases!available!in!kits!or!individually!
Developed!Biocatalysts:!!
Libraries!of!enzymes!in!the!following!categories:!!
Lipases!
Transaminases!
Ene:Reductases!
Phosphatases!
Hydroxynitrilases!
Sulfatases!
Glucosidases!
!
!
'
'
!
272!
!
!
!!
Life'Technologies'
http://www.lifetechnologies.com/!!
3175!Staley!Road!
Grand!Island,!NY!14072!
USA!
!
Tel:!+1:800:955:6288!
Fax:!+1:800:331:2286!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!(with!the!merger!of!Invitrogen!and!Applied!Biosystems)!
$3.8!billion!revenue!(2012),!10,000!employees!
Public:!LIFE!
Very!small,!Life!Technologies!offers!over!50,000!total!products.!!
Molecular!biology!enzymes!for!DNA!and!RNA!manipulation,!analysis,!and!
amplification.!
NA!
Lab!scale.!!Some!in:house!production!likely.!
Gregory!T.!Lucier,!CEO!
NA!
Global,!in!180!countries.!
+++!
+!(standard!molecular!biology!tools)!
+!(Life!has!a!protein!expression!services!team)!
Life!Technologies!agreed!to!be!acquired!by!Thermo!Fisher!Scientific!for!over!$13!billion!in!April!2013.!
Products:!!
Extensive!line!of!enzymes!for!research!in!the!following!categories:!
DNA!Polymersases,!Restriction!enzymes,!Proteases,!Phosphatases,!Kinases,!Ligases,!Topoisomerase,!
DNA!and!RNA!nucleases!
!
!
'
'
!
273!
!
!
!!
Lonza'
http://www.lonza.com/!!
Muenchensteinerstrasse!38!
4002!Basel!
Switzerland!
Tel:!+41!61!316!81!11!
Fax:!+41!61!316!91!11!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1897!
10,000!employees!
Public:!LONN!
Very!small!
Molecular!biology.!
Pseudomonas,atlantica,
Bulk!
Richard!Ridinger,!CEO!
NA!
Global!
+++!
+!!
:!
From!the!company!website:!“Founded!in!1897!in!the!Swiss!Alps,!Lonza!today!is!one!of!the!world’s!
leading!life!sciences!companies.!!We!harness!science!and!technology!to!create!products!that!make!
people’s!lives!safer!and!healthier!and!that!enhance!the!overall!quality!of!life!and!well:being.!!!Our!
products!range!from!active!pharmaceutical!ingredients!and!stem:cell!therapies!to!drinking!water!
sanitizers,!from!Vitamin!B!compounds!and!other!nutritional!ingredients!to!the!custom!development!of!
agricultural!products,!and!from!industrial!preservatives!to!microbial!control!solutions!that!combat!
dangerous!viruses,!bacteria!and!other!pathogens.”!
Product:!
Beta:agarose!(for!gel!extraction!in!the!life!sciences)!
!
274!
!
!
!!
Lucigen!
http://lucigen.com/!!
2905!Parmenter!Street!
Middleton,!WI!53562!
USA!
Tel:!+1:608:831:9011!
Fax:!+1:608:831:9012!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1998!
40!
Private!
Enzymes!are!a!portion!of!a!much!broader!range!of!products!and!services!in!
life!sciences.!
DNA!polymerases,!DNA!modifying!enzymes,!carbohydrate!hydrolytic!
enzymes.!!!
E.,coli!for!DNA!polymerases!and!DNA:modifying!enzymes.!!Dictyoglomus,
turgidum,,Bacillus,,Clostridium,thermocellum,!and!an!undisclosed!strain!for!
carbohydrate!hydrolytic!enzymes.!
Lab!scale!
David!Mead,!Founder!and!CEO!
Global!distribution!network.!!In!2006,!Lucigen!spun!off!C5.6!Technologies,!
and!this!spin!off!company!supplies!the!carbohydrate!hydrolytic!enzymes.!!!
Global!
++!
++!
:!
From!the!company!website:!“Located!in!Middleton,!Wis.,!Lucigen!delivers!advanced!molecular!biology!
products!and!services!to!life!scientists!by!inventing!solutions!to!the!most!difficult!problems!in!DNA!
cloning,!amplification,!protein!expression,!and!next!generation!sequencing.!With!a!focus!on!simplifying!
genomic!research,!Lucigen!offers!a!wide!selection!of!cloning!kits,!competent!cells,!and!enzymes!that!
enable!scientists!to!quickly!and!easily!complete!even!the!most!challenging!molecular!biology!
experiments.”!
!
!
!
275!
!
!
!!
Products:!
RND!nuclease!
DNA!Polymerases!
Cellulases!
Xylanases!
Curdlanase!
Beta:mannanase!
Licheninase!
Beta:galactosidase!
Alpha:glucuronidase!
Cellobiohydrolases!
Beta:xylosidase!
Beta:glucanases!
Arabinfuranosidase!
!
!
!
276!
!
!
!!
Lumis'Biotech'Pvt.'Ltd.'
http://www.lumisbiotech.com/!!
501,!Arun!Chambers,!Tardeo!Road!
Mumbai!–!400034!
India!
Tel:!+91:22:6666!2690!/!91!/!92!/!93!/!94!
Fax:!+91:22:6740!2555!
Emails:[email protected];[email protected];[email protected]!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1995!
Parent!company!has!2,400!employees!
Private,!a!subsidiary!of!K:Genix!Group!
100%!
Feed,!textiles,!food,!baking,!juice,!winemaking!and!brewing.!!!
Many,!both!solid!state!and!submerged!fermentations.!
NA!
NA!
NA!
NA!
++!
:!
From!the!company!website:!“Lumis!Biotech!is!one!of!the!foremost!enzyme!manufacturing!companies!in!
Asia.!The!core!strength!of!Lumis!lies!in!Applied!Industrial!Enzymology.!We!have!designed!and!launched!
certain!innovative!products!for!the!food,!feed!and!the!textile!industry!through!state:of:the:art!
manufacturing!facilities,!high!tech!laboratory!equipments,!leading!edge!quality!assurance!system!and!
industry!specific!knowledge.!This!makes!Lumis!an!unique!enzyme!company!which!helps!to!reduce!
production!cost!and!increase!efficiency!of!the!process.”!
Products:!
Hemicellulase!
Amyloglucosidase!
Amylases!
!
277!
!
!
!!
Pectinases!
Cellulases!
Laccases!
Catalase!
Phytase!
Xylanase!
Beta:glucanase!
Lipases!
Mannase!
Galactosidase!
Proteases!
Papain!
!
!
'
'
!
278!
!
!
!!
Lybradyn,'Inc.'
http://www.lybradyn.com/!!
125!Windsor!Dr.,!Ste.!126!
Oak!Brook,!IL!60523!
USA!
Tel:!+1:630:575:8313!
Fax:!+1:630:282:7117!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2000!
1:10!employees!
Private!
Very!small!
Selective!hydrolysis,!chiral!synthesis!(esterase,!lipase!and!racemase),!anti:
biofilm!(lactonase),!and!pesticide/chemical!weapons!detoxification!and!
detection!(organophosphorus!hydrolase)!
E.,coli,,Pseudomonas,,Bacillus,,Thermus,!cyanobacteria,!yeast!
Small,!in:house!production.!
John!Aikens,!Co:Founder!and!CEO;!Wendy!Aikens,!Co:Founder!and!President!
NA!
NA!
NA!
+!
+!
Lybradyn!is!a!small!company!that!does!contract!R+D!for!genetic!engineering,!protein!expression,!
biocatalyst!process!development,!and!consulting!in!these!areas.!
Products:!
Esterase,!Lipase,!Racemase,!Lactonase,!Organophosphate!hydrolase!
!
'
'
!
279!
!
!
!!
Lyven'
www.lyven.com!!
Zac!Normandial!
11!avenue!du!pays!de!Caen!
14460!Columbelles!
France!
Tel:!+33:2:31:35:05:30!!
Fax:!+33:2:31:34:54:49!
Email:!lyven@soufflet:group.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1980!
About!50!employees!
Subsidiary!of!Soufflet!Group!
Nearly!all!sales!are!enzymes!
Feed,!brewing!and!winemaking,!textiles,!baking,!fruit!and!juice.!
Strains!of!Aspergillus,,Bacillus,,Trichoderma.!!Extraction!from!plant!and!
animal!tissue.!
NA!
Distributes!through!sister!company!AIT!Ingredients!and!Acatris.!
Europe!
NA!
++!
:!
Lyven!is!a!manufacturer!of!enzymes!that!are!distributed!in!Europe!by!AIT!Ingredients!and!Acatris.!
Products:!
Pentosanases/xylanase!
Beta:glucanases,!
Proteases!
Pectinases!
!
280!
!
!
!!
Cellulases!
Amyloglucosidases!
Alpha:amylases!
Phytase!
Glucose!oxidase!
!
!
'
'
!
281!
!
!
!!
M'L'CHEMICALS'(INDIA)'PVT'LTD.'
www.mlindia.com!!
REAL!CHAMBERS!
2ND!FLOOR,FLAT!NO:6!
65/30,MADDOX!STREET,CHOOLAI!
CHENNAI!:!600!112!
TAMIL!NADU!
India!
Tel:!+!91!:!44!:!65197000!
Fax:!+!91!:!44!:!42064315!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1995!
1:10!employees!
Private!
Most!revenues!from!enzyme!sales!
Leather!and!textiles!
Bacillus,,Trichoderma,
Bulk.!!In:house!manufacture.!
NA!
Dealers!throughout!India!
India!
NA!
++!
:!
M!L!CHEMICALS!(INDIA)!PVT!LTD.!serves!the!Indian!leather!and!textile!industries.!!The!company!
manufactures!and!sells!enzymes!and!a!limited!set!of!chemicals.!!!
Products:!
8!enzyme!formulations!that!include:!
Proteases,!Lipases,!Alpha:amylases,!Cellulases!
!
282!
!
!
!!
Maps'Enzymes'Limited'
http://www.mapsenzymes.com/!!
302,!Shapath:3!
S.G.!Road!
Ahmedabad!380054!
India!
Tel:!+91!(79)!26859971:74!
Fax:!+91!(79)!26859975!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1975!
150!enployees!
Private!
Major!portion!of!revenues.!
Textiles,!leather,!baking,!alcohol,!brewing,!detergent,!starch!and!animal!feed!
NA!
Mr.!Piyush!Palkhiwala,!Chairman!&!Managing!Director;!Dipal!Palkhiwala,!
Head!of!Business!Operations;!Bhavin!Palkhiwala,!Head!of!Finance !
NA!
Global!
NA!
++!
NA!
From!the!company!web!site:!“Maps!is!a!pioneer!biotechnology!company!producing!enzymes!and!
microorganisms!since!1975.!Today!we!are!listed!among!the!Top!50!Biotech!companies!in!India.!With!a!
sales!network!spread!across!4!continents!in!22!countries!and!a!product!portfolio!of!60+!products!for!
more!than!10!different!industries,!we!provide!biotech!solutions!to!improve!industrial!performance!and!
quality.”!!
Products:!
About!60!product!formulations!are!sold!including!formulations!of!the!following:!
Cellulases!
!
283!
!
!
!!
Proteases!
Phytase!
Catalase!
Glucoamylase!
Glucanases!
Xylanases!
'
'
!
284!
!
!
!!
Megazyme'International'Ireland'
http://www.megazyme.com/!!
Bray!Business!Park!
Bray,!Co.!Wicklow!
Ireland!
Tel:!+353:1:2861220!!
Fax:!+353:1:2861264!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
About!35!employees!
Private!
Large!portion!of!revenues!from!enzyme!sales.!98%!of!sales!are!exports.!
Diagnostics,!analytics,!animal!feed,!baking,!biofuels,!detergents,!brewing!and!
winemaking,!dairy,!textiles.!
Many!
Grams!to!kgs!
Barry!McCleary,!CEO!
Many!distributors!
Global!
NA!
+++!
:!
From!the!company!website:!“Megazyme!International!Ireland!is!a!privately!owned!biotechnology!
company!specialising!in!the!development,!manufacture!and!supply!of!diagnostic!test!kits!and!reagents!
for!the!food,!feed,!dairy!and!wine!industries.!!Megazyme!markets!a!range!of!over!500!products….”!
Products:!
E:ACSBS!RecAcetyl:CoA!synthetase!(B.!subtilis)!
E:OGLYEF!Recendo:α:N:Acetylgalactosaminidase!(E.!faecalis)!
E:ANAGM!Recα:N:Acetylgalactosylaminidase!(microbial)!
E:BNAHEX!Recβ:N:Acetylhexosaminidase!(microbial)!
!
285!
!
!
!!
E:AXEAO!RecAcetylxylan!esterase!(Orpinomyces!sp.;!regular)!
E:AXEAOB!RecAcetylxylan!esterase!(Orpinomyces!sp.;!large)!
E:ACPEC!RecAcid!phosphatase!(E.!coli)!
E:AMPK!RecAdenylate!kinase!(myokinase)!(prokaryote)!
E:ADHEC!RecAlcohol!dehydrogenase!(E.!coli)!
E:ALGLS!RecAlginate!lyase!(Sphingomonas!sp.)!
E:ALPEC!RecAlkaline!phosphatase!(E.!coli)!
E:ANAAM!α:Amylase!(A.!oryzae)!
E:BAASS!α:Amylase!(Bacillus!amyloliquefaciens)!
E:BLAAM!α:Amylase!(B.!licheniformis)!
E:BLAAM100!α:Amylase!(B.!licheniformis)!
E:PANAA!α:Amylase!(Porcine!Pancreatic)!
E:BARBL50!β:Amylase!(barley;!liquid)!
E:BARBL100!β:Amylase!(barley;!liquid)!
E:BARBP!β:Amylase!(barley;!powder)!
E:BAMBC!Recβ:Amylase!(B.!cereus)!
E:AMGDF!Amyloglucosidase!(A.!niger)!
E:AMGDF100!Amyloglucosidase!(A.!niger)!
E:AMGFR100!Amyloglucosidase!(A.!niger)!
E:AMGFR500!Amyloglucosidase!(A.!niger)!
E:AMGPU!Amyloglucosidase!(Rhizopus!sp.)!
E:EARAB!endo:1,5:α:L:Arabinanase!(A.!niger)!
E:AFASE!α:L:Arabinofuranosidase!(A.!niger)!
E:AFAM2!Recα:L:Arabinofuranosidase!(novel!specificity)!
E:ABFCJ!Recα:L:Arabinofuranosidase!(C.!japonicus)!
!
286!
!
!
!!
E:ABFCT!Recα:L:Arabinofuranosidase!(C.!thermocellum)!
E:ARBACJ!Recendo:/exo:Arabinanase!(C.!japonicus)!
E:ASNEC!RecAsparaginase!(E.!coli)!
E:DIPEP!Recα:Aspartyl!dipeptidase!(E.!coli)!
E:CBHI!Cellobiohydrolase!I!(T.!longibrachiatum)!
E:CELAN!Cellulase!(endo:1,4:β:D:glucanase)!(A.!niger)!
E:CELBA!RecCellulase!(endo:1,4:β:D:glucanase)!(B.!amyloliquefaciens)!
E:CELTM!RecCellulase!(endo:1,4:β:D:glucanase)!(T.!maritima)!
E:CELTE!Cellulase!(endo:1,4:β:D:glucanase)!(T.!emersonii)!
E:CELTR!Cellulase!(endo:1,4:β:D:glucanase)!(T.!Longibrochiatum)!!
E:CITEC!RecCitrate!synthase!(E.!coli)!
E:CREA!RecCreatinase!(Bacillus!sp.)!
E:CMPK!RecCytidylate!kinase!(prokaryote)!
E:DIAEC!RecDiaphorase!(E.!coli)!
E:FAERU!RecFeruloyl!esterase!(rumen!microorganism)!
E:FAEZCT!RecFeruloyl!esterase!(C.!thermocellum)!
E:FDHCB!RecFormate!dehydrogenase!(C.!boidini)!
E:FRMXLQ!Fructanase!mixture!(purified;!liquid)!
E:FUCTM!Recα:Fucosidase!(thermostable)!(T.!maritima)!
E:FUCM!1,2:α:L:Fucosidase!(microbial)!
E:EGALN!endo:1,4:β:D:Galactanase!(A.!niger)!
E:GALCJ!Recendo:1,4:β:D:Galactanase!(C.!japonicus)!
E:GALCT!Recendo:1,4:β:D:Galactanase!(C.!thermocellum)!
E:GALDH!RecGalactose!dehydrogenase!(soil!prokaryote)!
E:GALMUT!RecGalactose!dehydrogenase!/!Galactose!mutarotase!
!
287!
!
!
!!
E:AGLAN!α:Galactosidase!(A.!niger)!
E:AGLANP!α:Galactosidase!(A.!niger)!powderNEW!
E:AGLGU!α:Galactosidase!(guar)!
E:BGLAN!β:Galactosidase!(A.!niger)!
E:LICACT!RecNon:specific!endo:1,3(4):β:Glucanase!(C.!thermocellum)!
!E:EXBGOS!exo:1,3:β:D:Glucanase!/!β:Glucosidase!
E:LAMSE!endo:1,3:β:D:Glucanase!(Trichoderma!sp.)!
E:LAMHV!Recendo:1,3:β:D:Glucanase!(barley)!
E:EXG5AO!Recexo:1,3:β:D:Glucanse!(Aspergillus!oryzae)!
E:EXBGL!exo:1,3:β:D:Glucanase!(Trichoderma!sp.)!
E:EXBGTV!Recexo:1,3:β:D:Glucanse!(Tricoderma!virens)!
E:GAMP!RecGlucoamylase!P!(H.!resinae)NEW!
E:GLUKEC!RecGluconokinase!(E.!coli)!
E:GOXCA!Glucose!oxidase!/!Catalase!mixture!(eukaryote)!
E:GPDH5!Glucose:6:phosphate!dehydrogenase!(L.!mesenteroides)!
E:GPDHEC!RecGlucose:6:phosphate!dehydrogenase!(E.!coli)!
E:TSAGL!α:Glucosidase!(B.!stearothermophilus)!
E:TSAGS!Recα:Glucosidase!(B.!stearothermophilus)!
E:MALTS!α:Glucosidase!(maltase)!(yeast)!
E:TRNGL!α:Glucosidase!(transglucosidase)!(A.!niger)!
E:OAGUM!Oligo:α:1,6:GlucosidaseNEW!
E:BGLUC!β:Glucosidase!(A.!niger)!
E:BGOSAG!Recβ:Glucosidase!(Agrobacterium!sp.)!
E:BGOSTM!Recβ:Glucosidase!(thermostable)!(T.!maritima)!
E:BGOSPC!Recβ:Glucosidase!(thermostable)!(P.!chrysosporium)!
E:BGLAEC!Recβ:Glucuronidase!(E.!coli)!
!
288!
!
!
!!
E:AGUBS!Recα:Glucuronidase(Geobacillus!stearothermophilus)NEW!!
E:GOTEC!RecGlutamate!oxaloacetate!transaminase!(E.!coli)!
E:GPTBS!RecGlutamate!pyruvate!transaminase!(B.!subtilis)!
E:GLUTEC!RecGlutaminase!(E.!coli)!
E:GPO!RecGlycerol!3:phosphate!oxidase!
E:GMPK!RecGuanylate!kinase!(prokaryote)!
E:HEX10!Hexokinase!(yeast)!
E:HKGDH!Hexokinase!/!Glucose:6:phosphate!dehydrogenase!
E:HYLSP!RecHyaluronate!lyase!(novel!specificity)(soil!prokaryote)!!
E:HBDH!Rec3:Hydroxybutyrate!dehydrogenase!(prokaryote)!
E:INDHBS!Recmyo:Inositol!dehydrogenase!(B.!subtilis)!
E:ENDOIAN!endo:Inulinase!(A.!niger)!
E:EXOIAN!exo:Inulinase!(A.!niger)!
E:INVRT!Invertase!(fructofuranosidase)!(yeast)!
E:INVPD2!Invertase!(powder)!
E:INVPD5!Invertase!(powder)!
E:ISAMY!Isoamylase!(glycogen!6:glucanohydrolase)!
E:ICDHBS!RecIsocitrate!dehydrogenase!(B.!subtilis)!
E:DLDHLM!RecD:Lactate!dehydrogenase!(L.!mesenteroides)!
E:LLDHP!L:Lactate!dehydrogenase!(Porcine)NEW!
E:LICHN!Lichenase!(endo:1,3(4):β:D:glucanase)!(Bacillus!sp.)!
E:DMDHEC!RecD:Malate!dehydrogenase!(E.!coli)!
E:LMDHEC!RecL:Malate!dehydrogenase!(E.!coli)!
E:BMANN!endo:1,4:β:Mannanase!(A.!niger)!
E:BMABS!endo:1,4:β:Mannanase!(Bacillus!sp.)!
!
289!
!
!
!!
E:BMACJ!Recendo:1,4:β:Mannanase!(C.!japonicus)!
E:BMATM!Recendo:1,4:β:Mannanase!(T.!maritima)!
E:MNHPF!RecMannitol!dehydrogenase!(P.!fluorescens)!
E:BMOSCF!Recβ:Mannosidase!(C.!fimi)!
E:MAST!Malt!Amylase!Standard!
E:NADHPO!RecNADH!peroxidase!(E.!faecalis)!!
E:PCLYAN!Pectate!lyase!(Aspergillus!sp.)!
E:PCLYAN2!Pectate!lyase!(Aspergillus!sp.)!
E:PLYCJ!RecPectate!lyase!(C.!japonicus)!
E:PGDHEC!Rec6:Phosphogluconate!dehydrogenase!(E.!coli)!
E:PGIBS!RecPhosphoglucose!isomerase!(B.!subtilis;!regular)!
E:PGIBSB!RecPhosphoglucose!isomerase!(B.!subtilis;!large)!
E:PGIEC!RecPhosphoglucose!isomerase!(E.!coli;!regular)!
E:PGIECB!RecPhosphoglucose!isomerase!(E.!coli;!large)!
E:PGISC!RecPhosphoglucose!isomerase!(S.!cerevisiae;!regular)!
E:PGISCB!RecPhosphoglucose!isomerase!(S.!cerevisiae;!large)!
E:PGM!Recα:Phosphoglucomutase!(microbial)!
E:PMIEC!RecPhosphomannose!isomerase!(E.!coli)!
E:PTABS!RecPhosphotransacetylase!(B.!subtilis)!
E:PGALUSP!endo:Polygalacturonanase!M2!(A.!niger)!
E:BSPRPD!Protease!(subtilisin!A)!(B.!licheniformis)!
E:BSPRT!Protease!(subtilisin!A)!(B.!licheniformis)!
E:BSPRT100!Protease!(subtilisin!A)!(B.!licheniformis)!
E:PULKP!Pullulanase!M1!(K.!planticola)!
E:PULBL!Pullulanase!M2!(B.!licheniformis)!
!
290!
!
!
!!
E:RHAMS!Recα:Rhamnosidase!(prokaryote)!
E:SIALCP!Recexo:α:Sialidase!(C.!perfringens)!
E:SIALST!Recexo:α:Sialidase!(S.!typhimurium)!
E:SCOAS!RecSuccinyl:CoA!synthetase!(prokaryote)!
E:SUCR!Sucrase!(maltase)!(yeast)!
E:SUCRBG!Sucrase!plus!β:GalactosidaseNEW!
E:TMPK!RecThymidylate!kinase!(prokaryote)!
E:TREH!RecTrehalase!(prokaryote)!
E:UAO!RecUricase!(eukaryote)NEW!
E:XANLB!RecXanthan!lyase!(Bacillus!sp.)!
E:XYTR1!Xylanase!M1!(T.!viride)!
E:XYTR3!Xylanase!M3!(T.!longibrachiatum!;!pl!9.0)!
E:XYAN4!Xylanase!M4!(A.!niger)!
E:XYRU6!Xylanase!M6!(rumen!microorganism)!
E:XGP74!Recendo:1,4:β:Glucanase!(Paenibacillus!sp)!
E:XYLATM!Recendo:1,4:β:Xylanase!(T.!maritima)!
E:XYNACJ!Recendo:1,4:β:Xylanase!(C.!japonicus)!
E:XYNBCM!Recendo:1,4:β:Xylanase!(C.!mixtus)!
E:XYLNP!Recendo:1,4:β:Xylanase!(N.!patriciarum)!
E:XYNBS!Recendo:1,4:β:Xylanase!(B.!stearothermophilus!T6)!!
E:XYNAP!Recendo:1,4:β:Xylanase!(A.!punctata)!
E:XEGP!RecXyloglucanase!(Paenibacillus!sp.)!
E:BXSEBP!Recβ:Xylosidase!(B.!pumilus)!
E:BXSR!Recexo:1,4:β:D:Xylosidase!(S.!ruminantium;!regular)!
E:BXSRB!Recexo:1,4:β:D:Xylosidase!(S.!ruminantium;!large)!
!
291!
!
!
!!
Meito'Sangyo'
http://www5.mediagalaxy.co.jp/meito/kaseihin/index_e.html!!
1:22,!Nikko:cho,!Fuchu!
Tokyo,!183:0044!
Japan!
Tel:!+81!42:330:1721!
Fax:!+81!42:330:1725!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1945!!
About!550!employees!
Public!
Small!
Biocatalysis!!
Candida,rugosa,!Pseudomonas,stutzeri,,Rhizomucor,pusillus,!and!a!number!of!
other!microorganisms!
Akihiro!Mizutani,!President!
NA!
Global!
+++!
++!!
:!
Meito!Sangyo!is!a!conglomerate!with!three!main!divisions:!a!real!estate!division,!a!food!ingredients!
division,!and!a!fine!chemicals!division.!!The!fine!chemicals!division!manufactures!and!sells!dextran,!
dextran!derivatives,!and!enzymes.!!The!enzymes!offerings!include!lipases!for!chiral!transformations,!
such!as!the!lipases!from!Candida!rugosa!and!Pseudomonas!stutzeri.!Various!hydrolytic!enzymes,!chiefly!
lipases,!are!available!as!dry!powder!formulations!and!as!immobilized!preparations.!The!immobilized!
enzymes!are!typically!adsorbed!on!carriers!such!as!diatomaceous!earth!for!use!in!organic!solvents.!
Products:!
Lipases!from!Ps.,stutzeri,,C.,rugosa,,Rhizomucor!!
Phospholipase!D!
Immobilized!and!soluble!forms!
!
292!
!
!
!!
Menlo'Biotech'(Pty)'Ltd/Ecozymes'
www.menlobiotech.com!!!
98!Dover!Steet!!!
Norwich!
NR2!3LQ!!
UK!
Tel:!0835911481!
Fax:!0113163199!
Tel:!0113164063!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Recent!
Small!
Private!
Medium!
Lipases,!proteases,!and!cellulase.!
NA!
NA!
Robert!Gordon,!Managing!Director!(CEO)!
South!African!branch!of!the!company!is!called!Ecozymes.!
NA!
NA!
+!
:!
Summary!povided!by!Robert!Gordon,!CEO!of!Menlo!Biotech:!“Menlo!Biotech!is!a!privately!owned!
company!registered!in!South!Africa.!The!company!is!focused!on!the!manufacture!and!trading!of!
chemicals,!enzymes,!microorganisms,!and!cleaning!materials.The!company!is!set!up!for!the!contract!
manufacture!of!products!especially!the!blending!and!packing!of!dry!powders!and!liquids.”!
Products:!
Alkaline!Protease!
Cellulase!for!lignocellulosic!ethanol!
!
293!
!
!
!!
Fungal!Alpha!Amylase!
HT!Alpha!Amylase!
Lipase!
LT!Alpha!Amylase!
Neutral!Protease!
Pectinase!
!
!
'
'
!
294!
!
!
!!
Merck'KGaA'(EMD'Millipore)'
www.emdgroup.com!!
Frankfurter!Strasse!250!!
64293!Darmstadt!!
Germany!
Tel:!+49!6151!72:0!!
Fax:!+49!6151!72:2000!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1668!
38,000!employees!
Public!
Small!
Biocatalysis,!molecular!biology!!
Many!
Grams!to!kg.!!No!in:house!production!
Karl:Ludwig!Kley,!CEO!
Many!suppliers!
Global!
+++!
+++!
:!
Merck!is!a!pharmaceutical!company!and!has!a!division!that!sells!chemicals!and!research!tools!on!a!
laboratory!scale!worldwide.!!This!catalog!business!includes!enzymes.!!!
Products:!
Amino!transferases!
Nucleic!acid!polymerses!!
Farnesyl!and!geranylgeranyltransferases!
Glycosidases!
!
295!
!
!
!!
Kinases!
Lipases!
Phospholipases!
Nitric!oxide!synthases!!
Nucleases!
Phosphatases!
Proteases!
Proteoglycanases!
Reductases!
!
!
'
'
!
296!
!
!
!!
Metabomics'
http://www.metabomics.com!!
No.!1!Guotai!North!Rd.!
Zhangjiagang!215600!
China!
Tel:!+86:0512:56766505!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Recent!
NA!
Private!
NA!
NA!
NA!
Junhua!(Alex)!Tao,!CEO!and!Founder!
CEO!Tao!is!also!associated!with!EnzymeWorks,!and!scale!up!of!enzyme!
production!is!probably!done!through!EnzymeWorks.!
NA!
NA!
:!
+!(large!scale!fermentation!capabilities!claimed)!
Metabomics!is!a!provider!of!contract!services!for!enzyme!discovery,!expression,!and!engineering.!The!
target!applications!are!drug!discovery!and!generics,!fine!chemicals,!flavors!and!fragrances,!and!
agrochemicals.!!The!company!claims!to!have!bacterial,!yeast,!insect,!and!mammalian!cell!protein!
expression!capabilities.!!For!a!biocatalyst:oriented!company,!Metabomics!also!claims!to!offers!an!almost!
unheard!of!breadth!of!additional!expertise!in!metabolic!pathway!identification!and!manipulation.!!!
Metabomics!advertises!the!following!capabilities:!“Identify!and!characterize!gene!clusters!and!metabolic!
pathways!for!natural!product!biosynthesis;!!Combinatorial!biosynthesis!to!generate!novel!drug:like!
natural!products;!!Strain!modification!to!improve!the!titer!for!production!of!xenobiotics!and!
metabolites;!!Development!of!transfection!reagents!to!improve!delivery!efficiency!of!genetic!materials;!!
Enzyme!discovery!and!development:!from!genes!to!proteins;!!!Screening!of!biotransformation!toolboxes;!!!!
Development!of!biocatalytic!chemical!processes;!!!!Synthesis!of!complex!molecules:!chiral!compounds!
and!natural!products;!!Optimization!of!fermentation!processes!Isolation!and!separation!through!
nanofiltration,!ultrafiltration!and!resins.”!!'
!
!
297!
!
!
!!
MetGen'Oy'
www.metgen.fi!!
Rakentajantie!26!
20780!Kaarina!
Finland!
Tel:!+358!2!237!7077!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
12!
Private!
Large!portion!of!revenues!from!enzymes.!
Oxidoreductases!for!lignin:degradation!applications!in!pulp!and!paper,!and!
biofuels!and!biorefining!
E.,coli!and!yeast!
Bulk!
Alex!Michine,!CEO;!Alex!Azhayev,!CSO!
NA!
Current!pulp!and!paper!customer(s)!
+!(well:funded!by!venture!capital!investors)!
+!(enzymes!available,!customer!must!contact!company!for!list)!
:!
MetGen!was!founded!in!2007!by!to!commercialize!engineered!oxydoreductases!enzymes!for!
applications!in!pulp!and!paper,!and!biofuels!and!biorefining.!!MetGen!currently!has!12!employees!and!
has!raised!a!combined!€4.7!million,!including!a!funding!round!in!December!of!2012!of!€2.7!million.!!
Investors!include!Sofinnova!Partners!(Paris),!Emerald!Technology!Ventures,!Tekes,!Veraventure,!and!
Cleantech!Invest.!
Products:!
Oxidoreductases!
Laccase!
!
'
'
!
298!
!
!
!!
Millbo'
www.millbo.com!!
Via!Bellaria!s.n.!!
28069!Trecate!(NO)!
Italy!
Tel:!+39!0321795911!
Fax:!+39!0321795920!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Small!
Baking!
NA!
NA!
NA!
Global!
NA!
++!
:!
Millbo!is!an!ingredients!supplier!for!baking!applications.!The!company!provides!a!group!of!enzymes!for!
the!baking!application.!
Products:!
Amylases,!Proteases,!Lipases,!Phospholipases!
Glucose!oxidase,!Xylanase,!Hemicellulase!
!
!
'
'
!
299!
!
!
!!
Mirpain'
www.mirpain.com!!
Birlik!San.Sit.!3.Cad!!
No:!85!Beylikduzu!!
Istanbul!!
Turkey!
Tel:!+!90!212!875!01!11!
Fax:!+90!212!875!03!06!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Baking!
NA!
Bulk.!!Likely!no!in:house!production!capability!
NA!
NA!
45!countries,!global!
NA!
++!
:!
From!the!company!website:!“Mirpain!is!a!world!wide!known!Turkish!company!with!quality!bakery!
ingredients!produced!with!latest!technology.”!
Products:!
Xylanases,!Glucose!oxidase,!Proteases,!Alpha:amylases,!Glucoamylase,!Transglutaminase,!
Phospholipase,!Lipase!
!
'
'
!
300!
!
!
!!
Mühlenchemie'
Kurt:Fischer:Straße!55!
22926!Ahrensburg!
Germany!!
Tel:!+49!/!(0)!41!02!/!202:001!
Fax:!+49!/!(0)!41!02!/!202:010!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1923!
Owned!by!parent!company!the!Stern:Wywiol!Group!
Likely!a!majority!of!revenues!from!enzyme!sales.!
Flour!processing.!
NA!
Stefan!Schliesser,!Lennart!Kutschinski,!Managing!Directors!
Multiple!distributors.!!Enzymes!made!by!other!companies!within!the!Stern:
Wywiol!Group.!
Global!
NA!
++!
:!
From!the!company!website:!“Established!way!back!in!1923!and!a!member!of!the!Stern:Wywiol!Gruppe!
since!1990,!Mühlenchemie!is!one!of!the!world's!best:known!enterprises!in!the!field!of!flour!
improvement.!Mühlenchemie's!core!field!of!competence!is!developing!solutions!for!standardizing!and!
optimizing!flours!:!from!classic!flour!treatment!to!concentrates!for!ready:mixed!flours.”!
Products:!
The!company!sells!about!30!formulations!of!enzymes!for!flour!treatment!including:!
Amylases!
Hemicellulases!
!
301!
!
!
!!
Glucoamylase!
Esterases!
Lipases!
Xylanases!
Glucose!oxidase!
Sulphhydryl!oxidase!
Proteases!
!
!
!
'
'
!
302!
!
!
!!
MP'Biomedical'
http://www.mpbio.com/!!
29525!Fountain!Parkway!
Solon,!OH!44139!
USA!
Tel:!+1:800:854:0530!
Fax:!+1:440:337:1180!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1959!(founded!as!ICN)!
501:1000!employees!
Private!
Relatively!small!
Molecular!biology,!life!sciences,!industrial!biotechnologies,!diagnostics,!and!
biocatalysis.!
NA!
Lab!scale.!!No!in:house!manufacture.!
Milan!Panic,!Founder,!Owner,!and!CEO.!
Many!suppliers!
Global!
+++!
+++!
:!
MP!Biomedical!possesses!a!very!large!selection!of!enzymes!in!research!quantities!as!part!of!a!broader!
overall!portfolio!of!products!for!life!science!and!chemical!researchers.!!!
From!the!company!website:!“MP!Biomedicals!is!dedicated!to!giving!scientists!and!researchers!
innovative,!quality!tools!and!superior!service!to!aid!them!in!their!quest!for!ground:breaking!discovery!
and!turning!the!hope!for!life:changing!solutions!into!a!reality.!!The!company!manufactures!and!sells!
more!than!55,000!products!and!is!one!of!the!only!companies!in!the!industry!to!offer!a!comprehensive!
line!of!life!science,!fine!chemical!and!diagnostic!products.!!MP!Biomedicals!is!a!world:wide!corporation,!
with!ISO:certified!and!FDA:approved!manufacturing!and!distribution!facilities!throughout!the!globe!and!
headquartered!in!Southern!California.!A!vast!network!of!global!distributors!and!satellite!facilities!and!
offices!throughout!Europe,!Asia,!Australia!and!the!Americas!assures!customers!top!quality!products!
delivered!when!and!where!needed.”!
!
303!
!
!
!!
Products:!!
MP!Biomedical!has!an!extensive!selection!of!more!than!500!enzyme!offerings!in!small!research!
quantities.!!The!wide!range!of!enzymes!offered!covers!applications!in!molecular!biology,!life!sciences,!
industrial!biotechnologies,!diagnostics,!and!biocatalysts!for!chemical!transfomations.!!!
!
!
'
'
!
304!
!
!
!!
Nagase'ChemteX'Corp.'
http://www.nagasechemtex.co.jp/!!
1:1:17!Shinmachi!
Nishi:ku,!Osaka!550:8668!
Japan!
Tel:!+81:6:6535:2582!
Fax:!+81:6:6535:2174!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Private,!part!of!the!Nagase!Group!
Small!portion!
Yeast!cell!lysis,!phospholipid!modification,!starch!processing,!cosmetics,!
toiletry,!brewing,!chitin!degradation,!food!processing,!and!textiles.!!!
NA!
Bullk.!!In:house!production!likely.!!
Kazuo!Mitsuhashi,!President!
NA!
NA!
NA!
++!
:!
Nagase!ChemteX!is!a!manufacturer!of!specialty!chemicals!and!materials!including!epoxy!resins,!
photolithography!chemicals,!chelating!agents,!functional!monomers!and!polymers,!biocides,!and!
enzymes!and!bioproducts.!!!
Products:!
Phospholipase!D!
Amylase!
Chitinase!
Protease!
Lipases!
!
305!
!
!
!!
Lactase!
Cellulase!
Catalase!
Ascorbate!oxidase!
!
!
!
'
'
!
306!
!
!
!!
Nanjing'Chemlin'Chemical'Industry'Co.,'Ltd'
http://chemlin.guidechem.com/!!
Rm.902!Longyin!Plaza!
No.!217!Zhongshan!Rd.(N)!Nanjing!210009!
China!
Tel:!+86:25:83697070!
Fax:!+86:25:83453275!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
101:500!employees!
Private!
Small!
Biocatalysis,!carbohydrate!degradation!
NA!
Small!scale.!!In:house!production!unlikely.!
NA!
NA!
NA!
NA!
:!
Nanjing!Chemlin!Chemical!Industry!Co.,!Ltd.!is!a!supplier!of!fine!chemicals!and!laboratory!chemicals.!
Products:!
Lipases!(2)!
Cellulase!
!
!
'
'
!
307!
!
!
!!
New'England'Biolabs'
www.neb.com!!
240!County!Road!
Ipswich,!MA!01938:2723!
USA!
Tel:!+1:978:927:5054!
Fax:!+1:978:921:1350!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1972!
>400!employees!
Private!
Significant!contributor!to!revenues!
Molecular!biology.!
Many!
James!Ellard,!CEO!
Distributors!world:wide!
Global!
+++!
+++!(276!restriction!enzymes)!
+!
New!England!Biolabs!(NEB)!is!one!of!the!leading!companies!in!supplying!enzymes!in!molecular!biology.!!
Its!selection!of!DNA!and!RNA!enzymes!is!large!and!its!reputation!is!excellent.!
Products:!
Polymerases!
Ligases!
Phosphatases!
Kinases!
!
308!
!
!
!!
Nucleases!
Methyltransferases!
Sulfurylase!
Apyrase!
Recombinase!
Beta:agarase!I!
Pyrophosphatases!
!
'
'
!
309!
!
!
!!
Nordmann,'Rassmann'
www.nordmann:rassmann.com!!
!Kajen!2!
20459!Hamburg!
Germany!
Tel:!+49!(40)!36!87:0!
Tel:!+49!(40)!36!87!249!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1912!
280!employees!
Private!
Small!
Bakery,!dairy.!
NA!
Bulk.!No!in:house!production.!
Edgar!E.!Nordmann,!Gabriele!Henke,!Carsten!Güntner,!Managers!
NA!
Global!
NA!
+!
:!
From!the!website:!“Established!in!1912!by!Eduard!Nordmann!and!Fritz!Rassmann!as!a!company!trading!
in!natural!rubber,!Nordmann,!Rassmann!today!is!an!international!group!undertaking!with!a!shared!focus!
on!the!distribution!of!chemical!and!natural!raw!materials!as!well!as!specialty!chemicals.!With!our!group!
headquarters!situated!in!the!heart!of!Hamburg!and!eleven!subsidiaries!banded!throughout!Europe,!our!
distribution!and!sales!forces!serve!as!important!links!that!join!suppliers!from!around!the!globe!to!
customers!from!the!wider!manufacturing!industry.”!
Products:!
Two!bakery!and!dairy!enzymes:!!Undisclosed,!but!likely!to!be!xylanase!and!protease.!
!
!
!
310!
!
!
!!
Novozymes'
http://www.novozymes.com/!!
Krogshoejvej!36!
2880!Bagsvaerd!
Denmark!
Tel:!+45!4446!0000!!
Fax:!+45!4446!9999!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1925!
6,000!employees!
Public:!NZYM,!voting!control!from!parent!company!Novo!
Nearly!all!revenues!are!from!enzyme!sales!and!technological!assistance!
related!to!using!the!enzymes.!
Industrial!enzyme!applications.!!Novozymes!has!around!700!products!in!the!
categories!of!agriculture,!bioenergy,!biopharma,!food!and!beverages,!
household!care,!leather,!pulp!and!paper,!textile,!and!wastewater!solutions.!
Many!
World:leader!
Peder!Holk!Nielsen,!CEO!
Distributes!through!hundreds!of!regional!and!specialty!companies.!
Global!
+++!(strong!profits!and!growth)!
+++!(extensive,!not!retail!friendly)!
:!
Novozymes!is!the!premier!manufacturer!of!enzymes!worldwide.!!It!has!market:leading!positions!in!most!
of!the!enzyme!classes!in!which!it!operates.!!The!company!has!manufacturing!and!operational!expertise,!
and!spends!14%!of!revenues!on!R+D!to!continually!improve!its!products.!!Novozymes!also!brings!in!
products!and!expertise!through!acquisitions!of!other!companies.!!Currently,!the!company’s!cellulosic!
ethanol!enzyme!technology!is!gaining!adoption.!!Novozymes!sells!in!large!quantities,!and!it!is!often!
easier!for!most!customers!to!purchase!Novozymes’!products!via!distributors.!!Relevant!distributors!are!
listed!throughout!this!compilation!of!companies.!!!
Extensive!product!line!covering!all!aras!of!industrial!enyzmes.!
!
!
!
!
311!
!
!
!!
Novus'International,'Inc.'
http://www.novusint.com!!
20!Research!Park!Drive!!
St.!Charles,!MO!63304!
USA!
Tel:!+1:314:576:8886!
Tel:!+1:888:906:6887!
Fax:!+1:314:576:2148!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1991!
501:1000!employees!
Private!
Small!
Animal!feed!
Probably!strain!of!Aspergillus,niger!!
NA!
NA!
Global.!
+++!
+!
:!
Novus!is!a!manufacturer!and!supplier!of!animal!feed!and!additives.!
Products:!
Two!animal!feed!enzyme!products:!Cibenza!and!Idea.!!“CIBENZA®!CSM!feed!additive!is!an!enzymes!blend!
containing!xylanase,!alpha:galactosidase!and!beta:glucanase!activities!that!optimize!energy!utilization,!
improve!productivity!and!reduce!feed!cost.”!
!
'
'
!
312!
!
!
!!
Nutreco'
http://www.nutreco.com!!!
Prins!Frederiklaan!4!
AMERSFOORT,!3818!KC!
Netherlands!
Tel:!+31:33:4226100!
Fax:!+31:33:4226101!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1994!
10,000!employees!
Public:!NUO!
Small!
Animal!feed!
NA!
Knut!Nesse,!CEO.!
NA!
Global.!
+++!
+!
:!
Nutreco!is!an!animal!and!fish!nutrition!company.!
Product:!
Phytase!
!
!
'
'
!
313!
!
!
!!
Nzomics'Biocatalysis'
http://www.nzomics.com/!!
Ellison!Building!
Newcastle!upon!Tyne!
NE1!8ST!
UK!!
Tel:!+44!191!227!3550!
Fax:!+44!191!227!3519!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2006!
1:10!employees!
Private,!closely!associated!with!Northumbria!University!in!Newcastle,!
England!
Minority!revenue!stream.!
Biocatalysis!
E.,coli,
Small!
Prof.!Gary!Black,!Technical!Director;!Justin!Perry,!Commercial!Director!!
NA!
Major!drug!firms!and!contract!manufacturers!
NA!
+!
+!(small!scale)!
From!the!company!web!site:!“Nzomics!Biocatalysis!offers!products,!services!and!expertise!to!those!
companies!looking!to!use!biocatalysis!in!a!post:genomic!era.!This!presents!opportunities!for!R&D!teams!
to!exploit!state!of!the!art!advances!in!enzyme!production!and!optimization.”!
From!an!article!in!Chemical!and!Engineering!News:!“Based!at!Northumbria!University!in!Newcastle,!
England,!Nzomics!Biocatalysis!!was!founded!in!2006!by!a!chemist!and!a!biologist.!The!partners!thought!
they!would!sell!enzymes!such!as!nitrile!hydratases!that!were!useful!but!not!widely!available,!but!they!
have!shifted!to!offering!consulting!and!services!in!the!areas!of!custom!enzymes!and!libraries.”!
!
!
314!
!
!
!!
Products:!
Nitrile!hydratases!(9!enzymes,!individualy!or!in!kit!format)!
Pectate!lyases!(3!enzymes,!individualy!or!in!kit!format)!
Hyaluronase!!
Carboxyesterase!
Lipase!
!
!
'
'
!
315!
!
!
!!
NZYTech,'Lda.'
www.nzytech.com!!
Estrada!do!Paço!do!Lumiar!
Campus!do!Lumiar,!Edifício!E!:!R/C!
1649:038!Lisboa!
Portugal!
Tel:!+351.213643514!!
Fax:!+351!217151168!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
11:50!employees!
Private!
Molecular!biology,!carbohydrate!degradation,!diagnostics.!
Many!
Lab!scale!
Carlos!Fontes,!Managing!Director!
Prozomix!sells!NZYTech’s!polymerase!
Global,!distributors!in!multiple!countries!and!continents!
NA!
+++!
:!
NZYTech!offers!a!full!suite!of!molecular!biology!tools!including!DNA!reagents!and!consumables.!!The!
company!offers!molecular!biology!enzymes,!but!also!offers!enzymes!for!carbohydrate!hydrolysis!and!for!
analytical!and!diagnostic!applications.!!!!!
From!the!company!website:!“NZYTech!was!founded!in!June!2008!by!Professors!Carlos!Fontes!and!Luís!
Ferreira!in!order!to!explore!the!commercial!potential!of!the!carbohydrate:active!enzymes!characterized!
at!their!University!Laboratories!at!the!Faculty!of!Veterinary!Medicine!in!Lisbon.!NZYTech!aims!to!build!a!
reputation!in!the!fields!of!Molecular!Biology,!Carbohydrate!Research!and!Biochemical!and!Food!Analysis!
through!a!continuous!investment!in!research!and!innovation.”!
!
!
316!
!
!
!!
Products:!
RNase!
Polymerases!
Reverse!transcriptase!
Ligase!
Phosphatase!
!
!
'
'
!
317!
!
!
!!
OenoBioTech'SAS'
http://www.oenobiotech.com/!!
Paris!:!Ile!de!France!
30!rue!des!Terres!Fortes!
77600!Chanteloup!en!Brie!
France!
Tel:!+33!1!64027550!
Fax:!+33!1!64027245!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2011!
NA!
Private!
Likely!significant!portion.!
Winemaking!!
NA!
NA!
Verenium!supplies!the!enzymes!that!the!company!sells!
NA!
NA!
+!(small!assortment)!
:!
OenoBioTech!is!the!sister!company!of!WeissBiotech.!!It!was!set!up!to!distribute!enzymes!from!
Verenium,!and!materials!from!other!sources!like!yeasts!and!tannins,!to!the!wine!industry!in!Europe.!!It!
makes!no!products!of!its!own.!!
Products:!
Pectinases!
Lysozyme!
Hemicelluase!
Beta:glucosidase'
!
!
318!
!
!
!!
Oenobrands'SAS'
http://www.oenobrands.com!!
Parc!Scientifique!Agropolis!II,!bat!5!
2196!Blvd!de!La!Lironde.!CS!34603!
34397!Montpellier!Cedex!5!
France!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2010!
11:50!employees!
Joint!venture!between!DSM!and!AnchorBioTechnologies!
Winemaking!!
NA!
NA!
DSM(The!Netherlands)!and!AnchorBioTechnologies!(South!Africa)!
OenoBrands!operates!in!over!40!countries!through!its!global!distribution!
network.!
NA!
++!
:!
Oenobrands!is!a!leading!supplier!of!ingredients!for!the!wine!industry.!Developed!by!winemaking!experts!
in!close!contact!with!universities!and!institutes,!the!company!supplies!a!complete!range!of!wine!
biotechnology!ingredients!for!specific!applications.!Whether!producing!bulk!or!super!premium!wines,!
Oenobrands!enzymes,!wine!yeasts!and!fermentation!aids!provide!solutions!tailored!to!any!winemaking!
style.!
Products:!
Pectinases,!Lysozyme,!Beta:glucanase,!Beta:glycosidases,!Alpha:glycosidases!
!
'
'
!
319!
!
!
!!
OptiGene'
Unit!5!Blatchford!Road!!
Horsham!West!Sussex!RH13!5QR!
UK!
Tel:!+44(0)1403!274980!!
Fax:!+44(0)1403!271017!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
NA!
Private!
Small!
Molecular!biology!
NA!
Laboratory!scale!
NA!
Distributors!globally!
Global!
NA!
+!
:!
From!the!company!website:!“OptiGene!Limited!was!formed!in!2008!to!develop!and!deliver!advanced!
molecular!diagnostics!solutions!for!applications!across!a!range!of!market!sectors.!!OptiGene!was!
established!with!the!primary!goal!of!providing!the!highest!quality!instrumentation!and!performance:
leading!reagents!to!support!isothermal!amplification!of!DNA!and!RNA.”!
Products:!
DNA!polymerases!
'
'
!
320!
!
!
!!
ORBA'
www.orba.com.tr!!
Biokimya!San.!ve!Tic.!A.Ş.!
Okul!Cad.!26!Orhanlı!Tuzla!!
34956!Istanbul!
Turkey!
Tel:!+90!216!394!30!49!!
Fax:!+90!216!394!30!51!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1977!
11:50!employees!
Private!
Baking,!brewing,!animal!nutrition!
A.,oryzae,!others!undisclosed!
NA!
NA!
NA!
NA!
++!
:!
From!the!company!website:!“ORBA!is!an!enzyme!producer!with!an!emphasis!on!offering!you!tailored!
solutions!to!suit!your!production!process.!We!started!in!1977!by!producing!our!first!line!of!alpha:
amylase!products!for!the!baking!industry!to!prolong!bread!shelf:life.!Today!we!offer!our!products!and!
services!in!baking,!brewing,!distilling,!animal!nutrition,!starch!and!industrial!applications.”!!!
Products:!
Beta:glucanase!
Xylanase!
Phytase!
Proteases!
!
321!
!
!
!!
Papain!
Amylases!
Hemicellulases!
Glucose!oxidase!
Lipase!
Arabinoxylanase!
!
!
!
!
!
'
'
!
322!
!
!
!!
Oriental'Yeast'Company'
http://www.oyc.co.jp/!!!
3:6:10!Azusawa,Itabashi:ku!
Tokyo!174:8505!
Japan!
Tel:!+81:3:3968:1192!
Fax:!+81:3:3968:4863!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1929!
610!employees!
Owned!by!Nisshin!Seifun!Group!
Biocatalysis,!diagnostics.!!!
Many!proprietary!strains.!
Masashi!Nakagawa,!President;!Takao!Watanabe,!Managing!Director!
NA!
Global!
+++!(long!profitable!history)!
+++!(large!selection)!
+++!
Oriental!Yeast!Co.,!Ltd.!was!founded!to!provide!pure:culture!bread!yeast,!and!has!grown!into!a!company!
leveraging!its!fermentation!and!other!capabilities!into!a!wide!range!of!markets.!!Still!a!leader!in!food,!
OYC!offers!a!large!selection!of!enzymes!for!many!applications,!especially!for!baking!but!also!many!
enzymes!for!biocatalysis!and!diagnostics.!!The!company!has!offices!in!Europe,!China,!and!the!United!
States,!and!sells!globally.!!OYC!has!branched!out!into!many!different!areas!including!animal!feed!
ingredients,!food!ingredients,!laboratory!animals,!antibodies,!testing!and!diagnostics,!and!life!science!
products,!and!enzymes!make!up!just!a!portion!of!revenues.!!!
Products:!
Many.!!A!selection!includes:!
Aconitase!(Pig!heart)!
!
323!
!
!
!!
Alcohol!dehydrogenase!(Yeast)!
rhALT!(Human!liver)!
ASOD!(Cucumber)!
CE(PP)!(Porcine!pancreas)!
CK!(Rabbit!muscle)!
rCO!(Nocardia!sp.)!
CPase!Y!(Yeast)!
Diaphorase!(Clostridium!kluyveri)!
Enolase!(Yeast)!
Glucoamylase!(Rhizopus!sp.)!
rβ:Glucuronidase!(Bacteria)!
α:GDH!(Rabbit!muscle)!
GlDH(NADP)!(Yeast)!
GlDH!(Beef!liver)!
rGlDH(NADP)!(Bacteria)!
α:Glucosidase!(Yeast)!
β:Glucosidase!(Almond)!
GOD!(Microorganism)!
G:6:PDH!(Yeast)!
G:6:PDH!(Leuconostoc!mesenteroides)!
rG:6:PDH!(Leuconostoc!mesenteroides)!
Glutathione!reductase!(Yeast)!
γ:GT!(Beef!kidney)!
rhCK:MB!
rhCK:MM!
!
324!
!
!
!!
Hexokinase!(Kluyveromyces!fragilis)!
Hexokinase!(GRADE:S)!(Yeast)!
Hexokinase!(GRADE:I)!(Yeast)!
r3α:HSDH!(Bacteria)!
Isocitrate!dehydrogenase(NAD)!(Bacteria)!
Isocitrate!dehydrogenase!(NADP)!(Yeast)!
Isocitrate!dehydrogenase!(Taq)!(Bacteria)!
Lactate!dehydrogenase!(Pig!heart)!
Lactate!dehydrogenase!(Bacteria)!
Lactate!dehydrogenase!(Leuconostoc!mesenteroides)!
Lactate!dehydrogenase!(Rabbit!muscle),!
Lactate!dehydrogenase!(Chicken!heart)!
Malate!dehydrogenase!(Yeast)!
Malate!dehydrogenase!(Pig!heart)!
rMalate!dehydrogenase!(Bacteria)!
Myokinase!(Yeast)!
Maltose!phosphorylase!(Bacteria)!
Mutarotase!(Pig!kidney)!
rNTR!(Yeast)!
rProtocatechuate!3,4:dioxygenase!(Bacteria)!
6:PGDH!(Leuconostoc!mesenteroides)!
Phosphoglucomutase!(Rabbit!muscle)!
rp:hydroxybenzoate!hydroxylase!(Bacteria)!
Pyruvate!kinase!(R.M.)!(Rabbit!muscle)!
Peroxidase!(Horseradish!roots)!
!
325!
!
!
!!
PTA!(Leuconostoc!mesenteroides)!
Sucrose!phosphorylase!(Leuconostoc!mesenteroides)!
rUrease!(Bacteria)!
Uricase!(Yeast)!
Xanthine!oxidase!(Butter!milk)!
!
'
'
!
326!
!
!
!!
Parchem'
www.parchem.com!!
415!Huguenot!Street!
New!Rochelle,!New!York!10801!
USA!
Fax:!+1:914:654:6800!
Fax:!+1:914:654:6899!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
16:30!employees!
Private!
Small!
No!specific!markets!targeted;!enzymes!applicable!to!a!broad!range!of!
applications!including!baking,!dairy,!animal!nutrition,!filtration!aids,!etc.!
None.!
Ephraim!Rabin,!CEO!
Works!with!many!suppliers.!
Mostly!USA!based.!
NA!
++!
:!
Parchem!is!an!importer!and!distributor!of!a!large!range!of!specialty!chemicals!
Products:!
38!different!enzyme!products!including:!
Peptidase!
Phytase!
Phospholipase!
Pullulanase!
!
327!
!
!
!!
Xylanase!
Papain!
Proteases!
Lysozyme!
Lipases!
Glucose!oxidase!
Invertase!
Hemicellulase!
Cellulases!
Amylases!
Catalase!
Bromelain!
Beta:glucanase!
Galactosidase!
Amyloglucosidase!
Lactase!
!
!
'
'
!
328!
!
!
!!
PROCHIMICA'NOVARESE'S.p.A.'
http://www.prochimicagroup.com/!!
Via!Marconi!21!!
28060!S.!Pietro!Mosezzo!(NO)!!
Italy!
Tel:!+39!0321!485511!!
Fax:!+39!0321!468704!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Small!
Textiles!!!
NA!
NA!
NA!
NA!
!
+++!
+!
:!
Prochimica!is!a!conglomerate!of!specialty!chemical!makers!and!suppliers.!!One!of!its!main!markets!is!the!
textile!industry,!to!which!it!supplies!auxiliaries,!dyestuffs,!pigments,!and!enzymes.!
Products:!
Alpha:amylase!
Cellulase!
Laccase!
!
'
'
!
329!
!
!
!!
Proenzimas'Ltda.'
http://www.proenzimas.com/!!
Calle!56!Numero!5!N:65!
Bodega!4,!La!Flora!Industrial!
Cali!
Columbia!
Tel:!4476028!
Fax:!4466442! !
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
At!least!22!years!old!
NA!
Private!
Large!portion!of!total!revenues!
Animal!nutrition,!baking,!dairy,!brewing,!food!and!beverage,!starch!
processing.!!!
None!
NA!
NA!
NA!
NA!
+++!
:!
Proenzimas!is!an!importer,!developer,!and!supplier!of!enzymes.!!It!has!a!larger!catalog!of!available!
enzymes!for!use!in!many!industries.!!!
Products:!
Lactases!
Xylanases!
Alpha:amylases!
Proteases!
!
330!
!
!
!!
Lipases!
Transglutamases!
Papain!
Pectinase!
Glucose!oxidase!
Glucoamylase!
Invertase!
Dextranase!
!
'
'
!
331!
!
!
!!
Promega'Corp.'
http://www.promega.com/!!
2800!Woods!Hollow!Rd!
Madison!WI!53711:5399!
USA!
Tel:!+1:608:274:4330!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1978!
About!1,200!employees!
Private!
Small!
Molecular!biology!and!life!sciences.!
NA!
William!A.!Linton,!Chairman!and!CEO!and!Founder!
NA!
Promega!has!branches!in!15!countries!and!more!than!50!global!distributors!
serving!100!countries.!
+++!
++!
+!
From!the!company!website:!“With!a!portfolio!of!more!than!2,500!products!covering!the!fields!of!
genomics,!protein!analysis!and!expression,!cellular!analysis,!drug!discovery!and!genetic!identity,!
Promega!is!a!global!leader!in!providing!innovative!solutions!and!technical!support!to!life!scientists!in!
academic,!industrial!and!government!settings.”!
Products:!
DNA!Polymerases!
Glycosidases!
Proteases!
Luciferase'
!
!
332!
!
!
!!
Protean's.r.o.'
http://protean.cz/!!
Pod!Lesem!9!
373!16!Dobrá!Voda!u!Českých!Budějovic!
Czech!Republic!
Tel:!+420!380!120!427!
Tel:!+420!724!731!832!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
1:10!employees!
Private!
NA!
NA!
NA!
Up!to!gram!quantities!of!recombinant!proteins!
Ladislav!Burýšek,!Research!&!Development!Director!
NA!
NA!
NA!
:!
+!(small!scale)!
Protean!is!a!small!company!that!does!R+D!in!diagnostics!and!offers!some!diagnostics!kits!and!materials!
for!sale.!!The!company!also!does!recombinant!protein!expression!on!a!contract!basis,!on!a!small!scale.!
!
!
!
'
'
!
333!
!
!
!!
ProteoGen'Bio'S.r.l.''
http://www.proteogenbio.com!!
Viale!Rinaldo!Piaggio!32!Pontedera!
PISA!56025!!
Italy!
Tel:!+39!0587!274816!
Tel:!+39!0587!970085!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2003!
1:10!employees!
Private!
NA!
Life!science.!
NA!
Small!
Massimiliano!Salerno,!President!and!CEO;!Roberto!Marangoni,!Advisor!from!
whose!academic!lab!the!company’s!technology!originated!
Partnered!with!Singredia!Life!Science!to!develop!and!manage!Proteogen!
Bio’s!international!commercial!strategy!
Merck!Serono,!Genentech,!Pfizer,!Amgen,!Thermo!Scientific,!
GlaxoSmithKline,!Teva!
NA!
+!
:!
From!the!company!website:!“ProteoGen!Bio!(PGB)!is!a!start:up!biotech!company,!possessing!an!
innovative!proprietary!technique!for!enzyme!immobilization!with!great!efficiency.!This!allows!us!to!
produce!the!DigesTip,!a!pipette:tip!device!for!the!one:minute!digestion!of!protein!for!sample!
preparation,!with!results!comparable!to!the!traditional!overnight!technique,!with!numerous!applications!
in!Proteomics,!Genomics,!and!Diagnostics.”!
Products:!
Immobilized!proteases!on!pipette!tips!
'
'
!
334!
!
!
!!
Prozomix'Limited'
http://www.prozomix.com/!!
Station!Court!
Haltwhistle!
Northumberland!
NE49!9HN!!!
UK!
Tel:!+44!(0)!1434!400455!
Fax:!+44!(0)!1434!322822!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!
1:10!employees!
Private!
Revenues!from!enzyme!sales,!contract!R+D,!and!from!the!Kyrobio!European!
grant.!
Biocatalysis!
NA!
Small!
Simon!Charnock,!Managing!Director!(CEO)!
Sells!enzymes!manufactured!by!SinoBios.!!Partnered!with!CLEA!Technologies!
for!immobilized!nitrile!hydratases.!
NA!
:!
++!
+!
From!the!LinkedIn!entry!of!the!CEO:!“Prozomix!Limited!is!a!privately!owned!UK!biotechnology!company!
that!develops,!produces!and!supplies!a!large,!diverse!and!rapidly!expanding!range!of!highly!purified!
recombinant!enzymes!and!proteins!of!known!sequence!with!associated!biochemical!reagents,!kits!and!
services!for!the!pure!and!applied!researcher.!!Our!drive!for!product!growth!respects!the!"Academiome"!
(i.e.!the!global!academic!resource)!as!evidenced!by!our!Commercial!Academic!Partner!(CAP)!
Programme,!that!enables!rapid!and!efficient!commercialisation!of!enzyme!/!protein!encoding!plasmids,!
in!exchange!for!a!generous!royalty!of!17.5!%.”!
!
!
335!
!
!
!!
Products:!
Sells!kits!and!individual!enzymes!in!the!following!categories:!!
Sterol!glycosyltransferases!(4!enzymes)!
Transaminases!(200!enzymes)!
Nitrile!hydratases!both!soluble!and!immobilized!(18!enzymes!each!kit)!
Keto!reductases!(96!enzymes)!
Glycoside!hydrolases!(71!enzymes)!
Ene!reductases!(200!enzymes)!
Cytochrome!P450s!(10!enyzmes)!
Alcohol!dehydrogenases!(200!enzymes)!
!
'
'
!
336!
!
!
!!
Prozyme'
http://www.prozyme.com!!
3832!Bay$Center$Pl!!
Hayward,!CA!94545!
USA!
Tel:!+1:800:457:9444!
Tel:!+1:510:638:6900!
Fax:!+1:510:638:6919!!
Fax:!+1:!510:300:3460!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1990!
NA!
Private!
Life!science/diagnostics:!glycobiology.!
NA!
Lab!scale!
NA!
NA!
NA!
NA!
++!!
NA!
From!the!company!website:!“ProZyme,!Inc.,!established!in!1990,!specializes!in!the!development!of!
value:added!reagents,!kits!and!platforms!for!improved!analytical!results.!Technologies!used!includes:!
microbial!fermentation!sciences;!large:scale!native!and!recombinant!purification!and!formulation;!assay!
development!and!analytical!services!for!our!customers.!Analytical!methods!employed!include!HPLC,!CE,!
bead:based!immunassays!and!ELISAs.!!Most!recently!ProZyme!has!commercialized!the!GlykoPrep™!
Sample!Preparation!Platform!to!significantly!speed!and!simplify!sample!preparation!for!glycoanalysis,!
yielding!high:quality!results!to!support!all!stages!of!biopharmaceutical!drug!development!and!
manufacture.”!
!
337!
!
!
!!
Products:!
Endoglycosidases!(PNGaseF,!Endo:H,!Endo!F2,!PNGaseA,!O:glycanase)!
Exoglycosidases!(sialidase,!alpha:galactosidase,!beta:galactosidase,!hexosaminidase,!galactosaminidase,!
alpha:mannosidase,!beta:mannosidase,!alpha:fucosidase)!
!
'
'
!
338!
!
!
!!
Purolite'
www.purolite.com!!
150!Monument!Road!
Bala!Cynwyd,!PA!19004!
USA!
Tel:!+1!610!668!9090!
Fax:!+1!610!668!8139!
!Email:[email protected]!!
Research!Site!in!the!UK!
Llantrisant!Business!Park!
Llantrisant,!Wales!CF72!8LF!
United!Kingdom!
Tel:!+44:1443:222336!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1981!
500+!employees!
Private!
None!
Enzyme!immobilization!
NA!
Bulk!
Allessandra!Basso,!PhD,!Lifetech!manager;!Erik!de!Vries,!PhD,!Technical!Sales!
Manager,!LIfetech!for!the!Americas!
Partnership!with!Codexis!for!the!immobilization!of!enzymes!
Global!
NA!
:!
:!
From!the!company!website:!“Purolite!was!founded!in!1981!and!is!a!leading!manufacturer!of!ion!
exchange,!catalyst,!adsorbent!and!specialty!resins.!They!have!developed!the!widest!platform!of!resins!
for!enzyme!immobilization!as!part!of!the!LifeTech!product!portfolio.!Headquartered!in!Bala!Cynwyd,!Pa.,!
!
339!
!
!
!!
the!company!has!ISO:certified!manufacturing!facilities!in!the!USA,!China,!and!Romania!and!operates!
dedicated!R&D!centers!in!the!USA,!China,!Romania,!Russia,!and!the!UK.!Purolite,!the!only!company!
focused!exclusively!on!the!ion!exchange!market,!has!40!sales!offices!in!more!than!30!countries.”!
Products:!
Purolite!sells!resins!for!enzyme!immobilization.!
About!the!immobilization!carriers!from!the!company!website:!“Purolite®!ECR!enzyme!carriers!are!
methacrylic!or!styrenic!polymers!with!various!functional!groups!on!the!matrix.!These!enzyme!carriers!
are!made!in!150!:!300!and!300!:!700!micron!mean!particle!size!range.!For!food!applications,!they!are!
also!available!in!300:!1200!micron.”!
!
!
'
'
!
340!
!
!
!!
Research'Products'Company'
http://researchprod.com/!!
P.O.!Box!1460!
Salina,!KS!67402!
USA!
Tel:!+1:785:825:2181!or!+1:800:234:7174!
Fax:!+1:785:825:8908!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1946!
NA!
Private!
Small!
Baking.!
NA!
Monte!White,!President!
NA!
NA!
NA!
+!!
:!
From!the!company!website:!“Since!1946,!Research!Products!Company!has!provided!the!milling!and!
baking!industries!with!innovative!ideas,!services!and!products!second!to!none.!We’ve!supplied!the!
industry!with!standard:setting!flour!oxidation!and!maturing!services,!mineral!premixes,!micro:ingredient!
dispensing!systems,!and!on:site!field!servicing.”!
Product:!!
Fungal!alpha:amylase!enzyme!premix!derived!from!Asperigillus,oryzae!
!
!
'
'
!
341!
!
!
!!
Roal'Oy'
http://www.roal.fi/!!!!
Tykkimäentie!15!
05200!Rajamäki!
Finland!
Tel:!+358!9!290!420!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
1991!
129!employees!
Jointly!owned!by!Associated!British!Foods!plc!and!Altia!Oy!(alcohol!beverage!
company)!
€47!million!annual!(2011:2012)!
A!large!selection!in!textiles,!paper!and!pulp,!detergent!enzymes,!baking,!
food,!animal!feed,!brewing!and!winemaking!
Trichoderma,,Aspergillus,,Bacillus!
Multi:ton!
Pekka!Kekki,!Managing!Director!
Joint!owner!AB!Enzymes!is!the!sole!distributer!for!Roal!
AB!Enzyme!
++!(appears!to!be!a!profitable!company)!
:!(Roal’s!enzymes!are!distributed!through!AB!Enzymes)!
:!(Joint!owner!AB!Enzyme!works!with!customers!to!provide!R+D!for!custom!
projects,!and!these!projects!are!likely!at!least!in!part!handed!off!to!Roal)!
!
Roal!Oy!is!one!of!the!larger!producers!of!enzymes,!and!exports!about!90%!of!its!products!outside!of!its!
home!country!of!Finland.!!The!company!was!founded!in!1991!as!a!joint!venture!between!Alkon!of!
Finland!and!Röhm!of!Germany,!and!is!now!owned!by!Altia!of!Finland!and!Associated!British!Foods!of!the!
United!Kingdom.!!In!2009,!the!company!expanded!its!production!facilities!by!about!40%.!!About!10%!of!
Notable!Facts:!Roal!Oy!scientists!publish!frequently.!!A!list!of!their!publications!can!be!found!on!their!
website.!!Recent!publications!have!focused!on!cellulases!and!biomass!degradation.!
Products:!
See!AB!Enzyme!and!AB!Vista!entries!for!products!offerings.!
'
'
!
342!
!
!
!!
RobinsonBioproducts'
www.robinsonbioproducts.com!!
PO!Box!1666!
#101!–!45!North!Railway!St.!
Okotoks,!Alberta,!T1S1B5!
Canada!!
Tel:!+1:403:938:0556!
Tel:!+1:888:968:0556!
Fax:!+1:403:938:0022!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
Small!
Private!
Small!
Animal!feed!
NA!
Daryl!Robinson,!President!
Enzymes!are!sourced!from!AB!Vista!
Canada!
NA!
++!
:!
From!the!website:!“Robinson!Bioproducts!Inc.!is!a!Canadian!Distributor!to!the!animal!feed!industry.!!We!
have!partnered!with!the!leaders!in!the!industry!to!supply!Canada’s!animal!feed!industry!with!the!very!
best!ingredients!and!animal!health!products.”!
Products:!
Phytase!
Xylanase!
!
!
343!
!
!
!!
Roche'
www.roche.com!!
Grenzacherstrasse!124!
Basel,!4070!
Switzerland!
Tel:!+41:9:732354295!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1896!
82,000+!employees!
Private!
Small!
Molecular!biology!and!diagnostics!
E.,coli,,Pichia,!others!
Severin!Schwan,!CEO!
NA!
Global!
+++!
+++!
:!
Roche!has!a!large!manufacturing!site!for!enyzmes!and!biotechnology!products!in!Penzberg,!Germany!
From!the!company!website:!“Headquartered!in!Basel,!Switzerland,!Roche!is!a!leader!in!research:focused!
healthcare!with!combined!strengths!in!pharmaceuticals!and!diagnostics.!Roche!is!the!world's!largest!
biotech!company!with!truly!differentiated!medicines!in!oncology,!virology,!inflammation,!metabolism!
and!CNS.!Roche!is!also!the!world!leader!in!in:vitro!diagnostics,!tissue:based!cancer!diagnostics!and!a!
pioneer!in!diabetes!management.”!
Roche!Diagnostics!acquired!Boehringer!Mannheim!(B:M)!in!the!late!1990s!and!has!developed!an!
extensive!diagnostic!enzyme!business!that!incorporated!the!B:M!product!range!and!expanded!
significantly!over!the!years.!!Headquarters!for!Roche!Diagnostics!in!Europe!is!in!Mannheim,!Germany,!
with!manufacturing!and!R!&!D!in!Penzberg,!Germany.!
'
'
!
344!
!
!
!!
Roche'Diagnostics'GmbH''
Sandhoferstrasse!116!!
DE:68305!Mannheim!!
GERMANY!
! !
!
Tel!+49:621:759!0!
! !
!
Fax!+49!621!759!2890!
!
http://www.roche.de/diagnostics/index.htm!
Roche!Diagnostics!GmbH!!
Nonnenwald!2!!
DE:82377!Penzberg!!
GERMANY!
+49:8856!60!0!
+49:8856!60!3896!
http://www.roche.de!
US'headquarters'for'Roche'Diagnostics'is'in'Indianapolis.'
Roche'Diagnostics'Corporation!
9115!Hague!Road!Indianapolis,!Indiana!46250!
USA!
+1:317:521:2000!
!
Products:!
Restriction!enzymes,!Polymerases,!Peroxidases,!!
Ligases,!Phosphatase,!Proteases,!Catalase!
!
!
345!
!
!
!!
Rossari'Biotech'Limited'
http://www.rossari.com/!!
201:A!&!B,!Ackruti!Corporate!Park,!LBS!Marg,!
Next!to!GE!Gardens,!Kanjurmarg!(W.),!Mumbai!:!400!078!
India!
Tel:!+91:22:6123!3800!!
Fax:!+91:22:6123!3846!!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1997!
200!employees!
NA!
Small!
Leather,!textile,!detergent!enzymes,!food!and!juice,!pulp!and!paper,!
winemaking!
NA!
Founders!and!Directors:!Mr.Sunil!Chari!and!Mr.Edward!Menezes!
Indozymes.com!is!an!authorized!distributor!for!Rossari!
NA!
NA!
++!(multiple!products!listed,!but!descriptions!are!sparse)!
:!!
Rossari!is!a!very!diverse!company!with!many!product!offerings!in!different!sectors!including!everything!
from!probiotics!to!construction!chemicals!to!knitting!oil.!!The!company!has!a!10!acre!manufacturing!site!
capable!of!producing!4600!metric!tons!of!product!per!month.!!!
Products:!
Partially!not!specified,!likely!include:!
Xylanases!
Cellulases!
Catalase!
!
346!
!
!
!!
Pectinases!
Amylases!
Glucanases!
Proteases!
Phytase!
Lipases!
!
'
'
!
347!
!
!
!!
S'I'CHEMICAL'INDUSTRIES''
www.papain.in!!
Gujar!Galli,!Shahada,!Tal:!Shahada!
Dist:!Nandurbar!!425409!Maharashtra!!
India!
Tel:!+91:2565:223735,!224135.!!
Tel:!+919881741435,!+919422791435!
Fax:!!+91:2565:223735!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1994!
Small!
Private!
Brewing,!meat!processing,!human!health,!dairy,!detergents,!textiles,!baking,!
starch!processing,!leather.!
Extraction!from!plant!tissue.!
Mr.!Kishor,!Managing!Director!
NA!
NA!
NA!
+!
:!
SI!Chemical!Industries!is!solely!focused!on!manufacturing!and!selling!the!enzyme!papain.!
Products:!
Papain!
!
!
!
!
348!
!
!
!!
Sartorius'Stedim'Biotech'GmbH'
Avenue!de!Jouques!ZI!des!Paluds!!
BP1051!AUBAGNE!Cedex,!13781!!
France!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1870!(as!parent!Sartorius)!
3156!employees,!ca.!600!million!Euros!annual!
Public!
Small!percentage!
DENARASE!endonuclease!from!c:LEcta!
Recombinant!expression!in!Bacillus,sp.!
1!megaunit!to!500!Kg!batches!offered!
Joachim!Kreuzburg,!Chairman!of!the!Board,!CEO!
c:LEcta!provides!the!endonuclease!
NA!
+++!
+!(just!one!enzyme!product)!
:!
Sartorius!Stedim!Biotech!is!a!public!company!with!74%!ownership!by!parent!company!Sartorius!AG.!!!
According!to!the!company!website:!“Sartorius!Stedim!Biotech!is!a!leading!provider!of!cutting:edge!
equipment!and!services!for!the!development,!quality!assurance!and!production!processes!of!the!
biopharmaceutical!industry.!Its!integrated!solutions!covering!fermentation,!cell!cultivation,!filtration,!
purification,!fluid!management!and!lab!technologies!are!supporting!the!biopharmaceutical!industry!
around!the!world!to!develop!and!produce!drugs!safely,!timely!and!economically.!Sartorius!Stedim!
Biotech!focuses!on!single:use!technologies!and!value:added!services!to!meet!the!rapidly!changing!
technology!requirements!of!the!industry!it!serves.!Strongly!rooted!in!the!scientific!community!and!
closely!allied!with!customers!and!technology!partners,!the!company!is!dedicated!to!its!philosophy!of!
“turning!science!into!solutions.”!Headquartered!in!Aubagne,!France,!Sartorius!Stedim!Biotech!is!listed!on!
the!Eurolist!of!Euronext!Paris.!With!its!own!manufacturing!and!R&D!sites!in!Europe,!North!America!and!
Asia!and!a!global!network!of!sales!companies,!Sartorius!Stedim!Biotech!enjoys!a!worldwide!presence.!Its!
key!manufacturing!and!R&D!site!is!in!Germany.!The!company!employs!approx.!3,000!people,!and!in!
2012!earned!sales!revenue!of!544.0!million!euros.”!
Products:!DENARASE!endonuclease!from!c:LEcta'
!
!
349!
!
!
!!
Scott'Laboratories'
www.scottlab.com!!
2220!Pine!View!Way!
Petaluma,!CA!94954!
USA!
Tel:!+1:707:765:6666!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1933!
About!75!employees!
Private!
Small!
Winemaking!!
NA!
Bruce!Scott,!President!
Scottlabs!sells!its!own!branded!enzymes!but!also!those!of!Lallemand!and!
Oenobrands.!
NA!
++!
++!
:!
From!the!website:!“For!over!seventy:five!years!Scott!Laboratories!has!been!meeting!the!needs!of!the!
beverage!industry!with!innovative!solutions!and!products!including!fermentation!goods,!filtration!
media,!equipment,!packaging!products!and!laboratory!services.”!
Products:!
Pectinases!
Beta:glucanases!
Hemicellulases!
Cellulases!
'
'
!
350!
!
!
!!
Season'Chemicals'and'Dyestuffs'
www.sesaonchemicals.com!!!
Flat!01,!28/F.,!EW!International!Tower!
120!:124!Texaco!Road,!Tsuen!Wan,!N.T.!!
Hong!Kong!
Tel:!!(852)!2609!0698,(852)!2609!0847,(852)!2408!3221,(852)!2409!0170!!!!
Fax:!(852)!2609!0715!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2001!
NA!
Private!
Small!
Textiles!
NA!
NA!
gets!enzymes!from!DuPont!Industrial!Biosciences!(fmr.!Genencor).!!!
NA!
NA!
+!
:!
Season!Chemicals!is!a!producer!of!materials!used!in!textile!processing,!including!enzymes.!
Products:!
Catalase!
Pectinase!
Cellulase!
Amylases!
!
'
'
!
351!
!
!
!!
Sekisui'Enzymes'
http://www.sekisuienzymes.com/!!
Sekisui!Diagnostics!(UK)!Ltd.!
50!Gibson!Drive!
Kings!Hill,!West!Malling!
Kent!ME19!4AF!
UK!
Tel:!+44!(0)!1732!220022!
Fax:!+44!(0)!1732!220024!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2012!
NA!
Private.!!Company!is!part!of!Sekisui!Diagnostics!Ltd.!which!is!in!turn!part!of!
Sekisui!Chemical,!a!large!public!company.!
NA!
Nearly!100!enzymes!for!diagnostic!applications.!
Wide!variety!of!organisms.!!!
Up!to!6,000!L!fermentations!in:house!production.!
Nick!Major,!Scientific!Director!
NA!
NA!
+++!
+++!
++!
Sekisui!originated!from!Whatman!Biochemicals,!a!supplier!of!enzymes!that!was!founded!in!1971.!!!
From!the!company!website:!“Sekisui!Enzymes,!a!Sekisui!Diagnostics!business!unit,!is!committed!to!the!
discovery,!development,!manufacture!and!distribution!of!enzymes!and!speciality!biochemicals!for!the!
global!healthcare!market.!With!a!proven!track!record!over!40!years,!our!quality,!expertise!and!customer!
focus!are!the!reasons!why!organisations!choose!Sekisui!Enzymes!as!their!partner!of!choice.!Our!parent!
organisation,!Sekisui!Chemical,!is!an!approximately!$10!billion!dollar!organization!headquartered!in!
Tokyo!that!employs!over!20,000!people,!with!over!200!companies!(comprised!of!approximately!115!
domestic!subsidiaries,!75!overseas!subsidiaries!and!17!affiliates).!!Sekisui!Chemical!is!organized!into!
!
352!
!
!
!!
three!main!areas:!a!housing!company,!an!urban!infrastructure!and!environmental!products!company!
and!a!High!Performance!Plastics!company.!Within!High!Performance!Plastics!is!Sekisui!Medical!and!
within!the!Sekisui!Medical!organization!is!Sekisui!Diagnostics.”!
Products:!
1:5:Anhydroglucitol:6:Phosphate!Dehydrogenase!
12!α:Hydroxysteroid!Dehydrogenase!
!
3!α:Hydroxysteroid!Dehydrogenase!
!!
3:Hydroxybutyrate!Dehydrogenase!
!!
Acyl:CoA!Oxidase!
!!
Acyl:CoA!Synthetase!
!!
ADP–dependent!Hexokinase!
!!
!
Alcohol!Dehydrogenase!A!(Secondary)! !
Alcohol!Dehydrogenase!B!(Secondary)! !!
Alcohol!Dehydrogenase!HI1!
!!
Alcohol!Dehydrogenase!HI2!
!!
Alcohol!Dehydrogenase!YK1!
!
Alcohol!Oxidase!!Candida!sp.!
Alcohol!Oxidase!!Yeast! !
Alkaline!Phosphatase! !!
Ascorbate!Oxidase!
!
Beta:Lactamases!
Bilirubin!Oxidases!
BpNPG₇!!
!
Catalase!
!
!
Cholesterol!Dehydrogenase!
Cholesterol!Esterase!
!!
!!
!
353!
!
Cholesterol!Oxidases!
!
Colipase!
!
Diacetinase!
!
!
!
Diaphorase!(NADH)!
!
Diaphorase!(NADPH)!
!!
DNASE!B!
!!
!!
Choline!Oxidase!!Arthrobacter!globiformis!
CNPG₃! !
!
!
Fructose:bisphosphate!Aldolase!HI1!
!
Glucoamylase! !!
Glucokinase!
!!
Glucose!1:dehydrogenase:NAD(P)!
!!
Glucose!Dehydrogenase!(PQQ)! !Bacterial!
!
Glucose!Dehydrogenase!FAD!Dependent!
!!
Glucose!Dehydrogenase!NAD!Dependent!
!!
Glucose!Oxidase!
!!
Glucose:6:Phosphate!Dehydrogenase! !!
Glutamine!Synthetase! !
Glycerol!Kinases!
Glycerol!Phosphate!Oxidase!
Glycerophosphorylcholine!Phosphodiesterase! !!
Hexokinases!
Ketoamine!Oxidase!
!!
L:α:Glycerophosphate!Oxidases!!
Laccase!!!
!
354!
!
!
!!
Lactate!Dehydrogenase!!!
Lactate!Oxidase!!!
Lipases! !!
Lysophospholipase!
!
Malate!Dehydrogenases!
Maltase!(α:Glucosidase)!
!!
Monoglyceride!lipase! !!
NAD!Synthetase!
!!
Oxaloacetate!Decarboxylase!
!
Penicillinase!!
Peroxidases!
!
Phosphofructokinases! !!
Phosphoglucose!Isomerase!
!
Phospholipases!!!
Purine!Nucleoside!Phosphorylase!
!!
Pyruvate!Decarboxylase!!!
Pyruvate!Kinases!
Pyruvate!Oxidase!
!!
Sarcosine!Oxidase!
!
Sphingomyelinase!
!!
Streptolysin!O! !!
Transketolase! !!
Tyramine!Oxidase!
!!
Urease! !,!Uricase!
!!
Xanthine!Dehydrogenase!
!
!
355!
!
!
!!
Senson'Ltd'
www.senson.fi!!
P.O.Box!95!
Niemenkatu!18!
FI:15141!Lahti!
Finland!
Tel:!+358!3!864!364!
Fax:!+358!3!781!8918!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
11:50!employees!
Private,!part!of!the!Polttimo!Group!
Small!
Dairy,!beverage,!baking.!
NA!
Jyrki!Heinimo,!Managing!Director!(CEO)!
NA!
NA!
NA!
+!
:!
From!the!website:!“Senson!Ltd!develops,!produces!and!delivers!ingredients,!and!solutions!based!on!
them,!to!the!beverage!and!food!industries!around!the!world.”!!
Products:!
Lactase!
Maltase!
Beta:amylase!
!
!
356!
!
!
!!
Shandong'Longda'BioBProducts'Co.,'Ltd.''
No.3!Yibo!Road!
Yishui!County!
Shandong!Province!276400!
China!!
Tel:!+86:539:2228377!!
Fax:!+86:539:2228377!
Email:!sales@longda:enzyme.com!!
Email:!gqw@longda:enzyme.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1976!
NA!
Private!
Nearly!all!revenues!are!enzyme!sales!
Alcohol!production,!starch!processing,!feed!and!food!processing,!textiles.!
Aspergillus,,Bacillus,,Trichoderma,
NA!
NA!
NA!
NA!
+!
:!
Shandong!Longda!Bioproducts!specializes!in!manufacturing!enzymes!for!a!variety!of!industrial!
applications.!!!
Products:!
Glucoamylase!
Alpha:amylases!
Pectinase!
!
357!
!
!
!!
Protease!
Cellulase!
Xylanase!
Pullulanase!
!
!
!
'
'
!
358!
!
!
!!
SHIN'NIHON'CHEMICAL'CO.,'LTD.'
http://www.aichi:brand.jp/corporate/type/chemical/shin:nihon:e.html!!
19:10!Showa,!Anjyo,!Aichi!446:0063!!
Japan!
Tel:!+81:566:76:5171!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1959!
>120!employees!
Owned!by!Aichi!Prefecture,!a!Japanese!group!of!companies!
Small!
Food!
Aspergillus,!Trichoderma,,Rhizopus,,Candida,!wild:types!
Large!scale!in:house!production!using!solid!(koji)!process!
NA!
Partnered!with!Bio:Cat!for!distribution!in!the!USA.!!The!company!sells!
through!TAKABIO.!!!
NA!
NA!
++!!
:!
Though!this!company!does!not!support!a!website!to!serve!English:speaking!markets,!it!is!one!of!the!
larger!enzyme!producers!in!Asia,!and!Danisco’s!2009:2010!annual!report!identifies!it!as!a!significant!
competitor.!!The!company!sells!through!the!company!Takabio:!http://www.takabio.com/!
From!the!company!website:!“SHIN!NIHON!CHEMICAL!manufactures!unique!enzyme!products!using!a!
solid!(koji)!culture!system!that!allows!various!enzymes!to!work!in!synergy.!This!R&D:oriented!company!
promotes!the!development!of!enzymes,!etc.!that!impose!less!chemical!load!on!the!environment.”!!
Products:!!
Cellulase!
Proteases!
Pectinase!
Amylases!
Galactosidase!
!
359!
!
!
!!
Phytase!
Hemicellulose!
Invertase!
Xylanase!
Catalase!
!
'
'
!
360!
!
!
!!
SibEnzyme'Ltd'
http://www.sibenzyme.com/!!
2/12,!Ak.!Timakova!Street!!
Novosibirsk:117,!630117!
Russia!
Tel:!+7!3833!334991!
Fax:!+7!3833!336853!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1991!
NA!
Private!
NA!
Molecular!biology!
NA!
Lab!scale!in:house!production!
NA!
USA!subsidiary!and!global!distributors!
Global!
++!(estimated)!
+++!(large!selection)!
:!
From!the!company!website:!“SibEnzyme!Ltd.!(Siberian!Enzyme,!SE),!is!a!privately!owned!Russian!
company!founded!in!1991.!SibEnzyme!Ltd.!is!located!in!Academtown!near!Novosibirsk!city!:!the!capital!
of!Siberia!and!a!geographic!center!of!Russia.!SibEnzyme's!primary!focus!is!production!of!enzymes!and!
related!products!for!molecular!biology,!PCR!and!genetic!engineering.!SE!product!line!includes!more!than!
200!enzymes,!several!perfect!DNA!ladders,!high!quality!dNTPs!and!DNA!preparations.!SibEnzyme!Ltd.!is!
one!of!the!leading!companies!in!restriction!endonucleases!production.!Sibenzyme!Ltd.!is!a!world!leader!
in!research!and!development!of!new!DNA!endonucleases.!A!first!site:specific!DNA!nickase!was!found!
and!characterized!at!SibEnzyme.”!
Products:!
More!than!200!enzymes:!!
!
361!
!
!
!!
Ligases!
Polymerases!
Endonucleases'
'
!
362!
!
!
!!
SigmaBAldrich'
http://www.sigmaaldrich.com/!!
3050!Spruce!St.!
St.!Louis,!MO!63103!
USA!
Tel:!+1:800:325:3010!
Fax:!+1:800:325:5052!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1934!
About!9,000!employees!
Public:!SIAL!
Small!
Biocatalysis,!molecular!biology,!diagnostics.!
NA!
Lab!scale.!!Likely!no!in:house!production.!
Rakesh!Sachdev,!President!and!CEO!
Collaborates!with!hundreds!of!manufacturers!globally!for!materials!supply.!
Global!
+++!
++!
:!
From!the!website:!“Sigma:Aldrich!is!a!leading!Life!Science!and!High!Technology!company!whose!
biochemical,!organic!chemical!products,!kits!and!services!are!used!in!scientific!research,!including!
genomic!and!proteomic!research,!biotechnology,!pharmaceutical!development,!the!diagnosis!of!disease!
and!as!key!components!in!pharmaceutical,!diagnostics!and!high!technology!manufacturing.!Sigma:
Aldrich!customers!include!more!than!1.3!million!scientists!and!technologists!in!life!science!companies,!
university!and!government!institutions,!hospitals!and!industry.!The!Company!operates!in!35!countries!
and!has!nearly!9,000!employees!whose!objective!is!to!provide!excellent!service!worldwide.”!
Products:!
Several!hundred!enzymes;!extensive!list!for!research!and!diagnostics!
!
'
'
!
363!
!
!
!!
SinoBios'
http://www.sinobios.com/!!
Suite!B903,!Tomson!Centre!
188!Zhangyang!Rd.!
Pudong!New!Dist.,Shanghai!200120!
China!!
Tel:!+86:21:58886205!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
300!employees!
Private!
Substantial!portion!of!revenues!is!enzymes!
Brewing,!food!processing,!textile,!leather,!pulp!and!paper,!feed.!!!
Assumed!to!be!many!including!Pichia!
Bulk.!!Some!in:house!production.!
NA!
Seeking!global!partners.!!Sells!enzymes!through!Prozomix!in!the!UK.!!!
Global.!!Market!Proportion!of!the!Products:!20%!for!international!market;!
80%!for!China!market.!!SinoBios’!main!customers!include!Tsingtao!Brewery,!
Carlsberg,!Asahi,!CRC,!Blueribbon,!Kingway,!AB!GmbH,!Dyadic,!etc.!!SinoBios!
is!the!main!supplier!of!ethanol!enzymes!for!Tianguan!Group!Co.,!Ltd.!the!
largest!alcohol!factory!in!China.!
Appears!to!be!sound!and!growing!
+++!
:!
SinoBios!sells!a!range!of!enzymes.!!It!both!imports!enzymes!into!China!that!others!make!and!sells!and!
exports!enzymes!that!manufactured!by!SInoBios!and!its!partners.!!SynBios!is!actually!a!group!of!
companies!involved!in!the!import/export,!manufacture,!and!distribution!of!mostly!enzymes!but!also!
other!biotechnology!products.!
Products:!
Amylases!
Proteases!
!
364!
!
!
!!
Pectinase!
Beta:glucanases!
Glucose!oxidase!
Lipases!
Lipoxygenase!
Hexose!oxidase!
Papain!
Xylanase!
Cellulases!
Mannase!
!
'
'
!
365!
!
!
!!
Specialty'Enzymes'and'Biotechnologies'Inc.'
http://www.specialtyenzymes.com/!!
13591!Yorba!Ave.!
Chino,!CA!91710!
USA!
Tel:!+1:909:613:1660!!
Fax:!+1:909:613:1663!
Specialty!Enzymes!and!Biotechnologies!is!the!USA!branch!of!the!India:based!global!enzyme!company!
Advanced!Enzymes.!!The!US!subsidiary!is!managed!by!Mr.!Vic!Rathi.!!
The!markets!served!are!the!same!and!the!parent!company!in!india:!leather,!textile,!pharmaceutical,!
animal!feed,!food,!paper,!environmental,!agriculture!and!speciality!applications.!!
For'more'information,'see'the'entry'for'Advanced'Enzymes.'
!
!
!
'
'
!
366!
!
!
!!
SpheriTech'Ltd.'
http://www.spheritech.com!
The!Heath,!Business!&!Technical!Park!
Runcorn,!Cheshire!WA7!4QX!
United!Kingdom!
Tel:!+44!1928!511331!
[email protected]!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2009!
1:10!employees!
Private!
Products!consist!of!polyspheres!for!immobilization!of!enzymes!and!cells.!
Additional!products!include!polymers!for!peptide!synthesis,!cell!culture!and!
regenerative!medicine!!
Biocatalysis!
NA!
Laboratory!
Dr.!Don!Wellings,!Founder!and!CEO!
NA!
NA!
NA!
!
+!(immobilizes!enzymes!as!a!service,!but!does!not!produce!enzymes)!
SpheriTech!provides!preparative!chromatography!and!custom!synthesis!of!peptides,!related!molecules!
and!small!organics.!From!our!research!laboratories,!we!are!able!to!provide!consultancy!in!preparative!
chromatography!plus!consultancy!in!peptide!synthesis!and!process!scale!peptide!synthesis.!Spheritech!
has!invented!a!process!for!the!manufacture!of!super:macroporous!polymer!scaffolds!for!cell!culture.!
This!novel!process!allows!for!a!more!precisely!controlled!pore!structure,!pore!volume!and!pore!
dimension!than!could!not!previously!be!achieved.!
Products:!
Polysphere!suppors!for!immobilization!of!enzymes!
Polymers!for!immobilization!of!cells!!
'
'
!
367!
!
!
!!
Sprin'Technologies'
http://www.sprintechnologies.com/!!
SPRIN!S.p.A.!
c/o!BIC!Incubatori!FVG!
Via!Flavia!23/1!
34148!Trieste!
Italy!
Tel:!+39!040!821492!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
1:10!employees!
Private!
Sales!consist!of!immobilized!enzyme!products,!enzyme!immobilization!
collaborative!revenues,!and!polymeric!materials!for!immobilization.!
Biocatalysis!
NA!
Capacity!claimed!for!immobilization!up!to!ton!scale!
Sara!Cantone,!Co:Founder!and!CEO!
Collaborates!with!and!sells!enzymes!through!Iris!Biotech.!!Collaborated!with!
Purolite!on!one!immobilization!project.!!Collaborated!with!MetGen!Oy!for!
immobilizing!laccases.!!SPRIN!distributes!its!products!and!services!in!the!US!
through!Itochu!Chemicals!America!Inc.!
NA!
NA!
+!
+!(immobilizes!but!does!not!produce!enzymes)!
Sprin’s!expertise!is!in!the!immobilization!of!enzymes,!and!the!company!offers!a!small!catalog!of!
immobilized!enzymes!and!polymers!for!immobilization.!!Furthermore,!SPRIN!offers!enzyme!
immobilization!as!a!service.!!Enzymes!which!the!company!has!worked!on!include!kinases,!
monooxygenases,!nitrilases,!epoxide!hydrolases,!transaminases,!glucoamylase,!invertase,!dextranase,!
and!laccases.!
Products:!
Immobilized!enzymes!including:!!
!
368!
!
!
!!
Galactosidase!
Endoinulinase!
Penicillin!G!amidase!(2!forms)!
Kit!of!12!immobilized!ketoreductases!
!
'
'
!
369!
!
!
!!
SternEnzym'
http://www.sternenzym.de/!!!
Kurt:Fischer:Straße!55!!
22926!Ahrensburg!
Germany!
Tel:!+49!/!(0)!41!02!/!202:002!
Fax:!+49!/!(0)!41!02!/!202:020!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1988!
NA!
Private,!owned!by!the!Stern:Wywiol!Gruppe!
Most!revenue!is!from!enzyme!sales.!
Food!and!beverage!!
Many,!including!custom:developed!strains.!
Bulk.!!Some!in:house!manufacturing.!
Lennart!Kutschinski,!Managing!Director!
NA!
NA!
NA!
+++!
:!
From!the!website:!“Established!in!1988,!SternEnzym!was!quick!to!realize!the!significance!of!enzymes.!As!
competent!enzyme!designers!we!create!multi:enzyme!compounds!for!the!production!of!baked!goods,!
pasta,!dairy!products,!alcoholic!drinks!and!much!more!from!micro:organism!strains,!some!of!which!we!
have!developed!ourselves.!We!create!each!enzyme!compound!individually,!in!close!cooperation!with!
our!customers,!so!that!it!fits!the!customer's!frame!of!reference!exactly.”!
Products:!
Amylases!
Glucoamylase!
Hemicellulase!
!
370!
!
!
!!
Invertase!
Lactoperoxidase!
Lipase!
Pentosanase!
Protease!
Xylanase!!
Sulphydryl!oxidase!
!
!
'
'
!
371!
!
!
!!
Strem'Chemicals,'Inc.'
http://www.strem.com/!!
7!Mulliken!Way!
Newburyport,!MA!01950:4098!!
USA!
Tel:!+1:978:499:1600!
Fax:!+1:978:465:3104!
Tel:!+1:800:647:8736!
Fax:!+1:800:517:8736!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
1964!
55!employees!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
NA!
Lab!scale.!!No!manufacturing!capacity!
Mike!Strem,!Founder!and!owner!and!President.!
Johnson!Matthey!and!Codexis!provide!the!enzyme!kits!that!Strem!then!sells!
retail!
Chemistry!companies!and!academia.!!Offices!in!USA!and!Europe.!
++!(small!but!long!profitable!history)!
++!
:!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
Private!
Small!
Biocatalysis!
Strem!Chemicals!is!well:known!provider!of!chemical!catalysts!and!reagents!and!custom!chemistry!
manufacturing!services,!and!has!recently!expanded!its!offerings!to!include!biocatalysts.!!Strem!was!
started!in!1964!by!Dr.!Mike!Strem!and!currently!has!about!55!employees.!!!Strem’s!catalog!contains!
more!than!4000!offerings.!!!
Products:!!
!
372!
!
!
!!
All!products!offered!individually!and!in!kit!format,!each!kit!with!multiple!enzymes!prpvided!by!Johnson!
Matthey!and!Codexis.!
Ene!reductases!
Esterases!
Ketoreductases!
Transaminases!
Lipases!
Lipases!
'
'
!
373!
!
!
!!
Sukahan'(WeiBfang)'BioBtechnology'Co.'Ltd'
www.sukahan.com!!
No.!1689!Wolong!East!Street!
High!&!New!Technology!Industrial!District!
Weifang,!Shandong!261061!
P.R.!China!
Tel:!+86!536:2225530!!400:991:8166!
Fax:!+86!536:2227077!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2004!
About!50!employees!
Private,!Australian!ownership!
Textile,!pulp!and!paper,!animal!feed,!wastewater!
Bacillus,,Aspergillus,!others!likely!
Bulk!manufacturer!
NA!
NA!
NA!
NA!
++!
:!
From!the!company!website:!“Sukahan!(Weifang)!Bio:Technology!Co.,!Ltd.!specializes!in!the!manufacture!
of!various!kinds!industrial!&!commercial!enzyme!preparations!and!related!product!lines.!Over!the!years,!
the!company!has!steadily!expanded!its!products!and!is!now!catering!to!diverse!industries!including!pulp!
and!paper!industry,!textile!industry,!agricultural!and!aquaculture!industry,!animal!feeds,!commercial!and!
household!sectors!and!many!more.”!
Products:!
Xylanase!
Beta:glucanase!
!
374!
!
!
!!
Proteases!
Cellulases!
Pectinases!
Amylases!
Lipases!
Phytase!
Glucoamylases!
!
!
!
'
'
!
375!
!
!
!!
Sunson'Industry'Group'Company'Limited'
http://www.chinaenzymes.com/!!
Suite!628,!China!Minmetals!Building!
Block!4!Anhuili!
Chaoyang!District,!Beijing,!100101!
China!
Tel:!+86:10:58603691!!
Fax:!+86:10:58603690!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1996!
More!than!500!employees!
Private!
Nearly!all!revenues!are!enzyme!sales.!
Animal!feed,!food,!brewing,!textile,!leather,!and!ethanol.!
NA!
NA!
NA!
Exports!to!30!countries!as!well!as!the!home!base!of!China!
NA!
++!
:!
From!the!company!website:!“Sunson!Industry!Group!Co.,!Ltd.!is!a!recognized!leader,!engaged!in!
exploring,!researching,!manufacturing!and!marketing!the!enzyme!industry!in!China!and!in!the!world.!In!
1996,!Sunson!started!enzyme!business!in!China.!After!a!decade!with!our!full!efforts,!Sunson!has!grown!
to!be!a!group!enterprise!with!2!R&D!centers,!4!manufacturing!bases,!over!30!branches!and!subsidiary!
companies,!and!more!than!500!employees!involving!approximately!50!R&D!staff.!Armed!with!expertise,!
we!Sunson!dedicate!into!the!industries!of!animal!feed,!food&!brewing,!textile&leather!and!ethanol.!We!
provide!not!only!state:of:the:art!enzymes,!but!also!complete!supports!and!solutions.”!
Products:!
Amylases!
!
376!
!
!
!!
Glucoamylase!
Phytase!
Proteases!
Cellulase!
Beta:glucanase!
Xylanase!
Pectase!
Glucose!oxidase!
!
!
'
'
!
377!
!
!
!!
SynBiocat'
http://www.synbiocat.hu/!!
Lázár!deák!u!4/1!Budapest,!1173!!
Hungary!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2010!
1:10!employees!
Private!
NA!
Biocatalysis!
NA!
Bulk!in!partner!facility.!!
László!Poppe,!Co:founder!and!CEO;!Zoltán!Boros,!Co:founder!
Partnered!with!Fermentia.!!Fermentia's!fermentation!capacity!is!ideally!
suited!to!support!bacterial,!fungal!and!recombinant!fermentations!from!10!
to!1000!litre!scale.!The!plant!is!also!equipped!with!separation!and!
purification!capabilities!for!down!stream!processing.!
NA!
NA!
+!
+!
From!the!company!website:!“SynBiocat!was!founded!in!2010!as!a!spin:off!company!of!Budapest!
University!of!Technology!and!Economics!(BME)!with!R&D!facilities!at!BME!and!enzyme!production!
facilities!at!the!pilot!plant!of!Fermentia!Ltd.!We!exploit!almost!30!years!expertise!in!synthetic!
biocatalysis!with!remarkable!references!and!co:operations!with!industrial!and!academic!partners.!!We!
offer!solutions!in!the!field!of!biocatalysis!and!synthetic!technologies!including!enzyme!screening!and!
production,!biocatalyst!immobilization!and!chemoenzymatic!process!development.!!We!produce!the!
robust!ImmBiocat!product!family!of!immobilized!enzymes!or!wholecell!systems.!!We!have!knowledge!
and!technologies!in!synthetic!applications!of!ImmBiocat’s!in!various!types!of!bioreactors!including!batch!
and!continuous:flow!systems.”!
Products:!
'
'
!
378!
!
!
!!
Syncozymes'
http://www.syncozymes.net!
Building!8,No.!128!Dieqiao!Road!
Hengmian!Town,!Pudong!
Shanghai!201319!
China!
Tel:!+1!86!21:6818:7185!
Fax:!+1!86!21:6818:7179!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2008!(as!Syncore)!
About!$5:10!million!annually!Syncozymes,!11:50!employees!
Private,!venture!funded!
The!company!offers!both!enzymes!and!chemical!intermediates.!
NA!
Syncozymes’!fermentation!capabilities!include!fermenters!of!greater!than!
100!L!capacity,!and!the!company!offers!enzyme/chiral!products!on!a!100!kg!
scale!with!a!3:4!month!lead!time,!likely!via!third:party!manufacture.!!!
James!Wen!is!listed!as!Founder!and!CEO!in!his!LinkedIn!profile.!!Junhua!(Alex)!
Tao!was!formerly!the!CEO,!but!has!since!left!to!lead!EnzymeWorks!and!
Metabomics.!
Acore!is!the!US!division!of!the!Chinese!company!Syncozymes!
NA!
+!(a!CRO/CMO,!which!have!experienced!headwinds!and!uneven!revenues)!
+++!(extensive)!
+!(small!scale)!
Syncozymes!offers!its!extensive!catalog!of!products!for!sale!(enzymes,!enzyme!kits,!and!chiral!enzyme:
derived!chemicals),!and!offers!research!and!development!services!on!a!fee:for:service!basis.!!The!
catalog!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!ene!reductases,!
ketoreductases,!transaminases,!lipases,!proteases,!amidases,!nitrilases,!nitro!reductases,!alcohol!
oxidase,!glycosidase,!nitrile!hydratase,!cytochrome!P450s,!and!many!others.!!Syncozymes!is!also!a!
distributor!in!China!of!products!from!the!Dutch!enzyme!immobilization!company,!ChiralVision.!!!
!
379!
!
!
!!
Syncozymes’!website!reveals!experience!and!equipment!for!chemical!research!and!development.!!The!
listed!capabilities!for!protein!engineering!suggest!that!the!company!is!capable!of!directed!evolution,!
DNA!suffling,!and!rational!design.!!The!company!website!lists!capabilities!in!bioinformatics,!genome!
mining,!and!high:throughput!screening.!!No!proprietary!new!technologies!are!listed,!and!the!company’s!
biology!department!includes!a!protein!engineering!group,!a!molecular!biology!group,!a!
biotransformation,!and!a!fermentation!group.!!The!company!also!lists!enzyme!immobilization!as!a!skill.!
Products:!
The!catalog!includes!hundreds!of!enzymes!in!many!enzyme!classes!including!the!following!in!individual!
and!kit!format:!!
Ene!reductases!!
Ketoreductases!
Transaminases!
Lipases!
Proteases!
Amidases!
Nitrilases!
Nitro!reductases!
Alcohol!oxidases!
Glycosidases!
Nitrile!hydratases!
Cytochrome!P450s!
Aldolases!
Amino!acid!dehydrogenases!
3a:hydroxysteroid!dehydrogenase!
Bilirubin!oxidase!
!
380!
!
!
!!
Uricase!
Ascorbate!oxidase!
Peroxidase!
Xanthine!oxidase!
Glycerol!kinase!
Pyruvate!kinase!
Urease!
Adenosine!deaminase!
!
'
'
!
381!
!
!
!!
Takabio'
http://www.takabio.com/!!
Parc!d'activités!Angers:Beaucouzé!!
4!rue!Joseph!Fourier!:!49070!Beaucouzé!!
France!
Tel:!+!33(0)2!41!88!66!66!!
Fax:!+!33(0)2!41!20!89!67!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
100%!
Food!
Mostly!Aspergillus,!some!Trichoderma,,Rhizopus,,Candida,!etc.!
Large,!through!partner.!!No!in:house!production.!
NA!
Partner!is!Shin!Nihon!Chemical!in!Japan,!which!supplies!all!the!product.!
NA!
NA!
+++!
:!
From!the!website:!“TAKABIO!has!been!created!to!represent,!sell!and!distribute!the!enzymes!produced!
by!SHIN!NIHON!CHEMICAL!from!Japan.!The!name!TAKABIO!is!a!tribute!to!Jokichi!TAKAMINE!and!“BIO”!
from!“Biology”,!the!science!of!life.”!
Products:!
Cellulase!
Proteases!
Pectinase!
Amylase!
Galactosidase!
!
382!
!
!
!!
Phytase!
Hemicellulose!
Invertase!
Xylanase!
Catalase!
!
!
383!
!
!
!!
TebuBbio'
http://www.tebu:bio.com!!
39!Rue!de!Houdan!BP!!
15!Le!Perray!en!Yvelines,!78612!!
France!!
Tel:!+33!1!30!46!39!00!
Fax:!+33!1!30!46!39!11!!
Email:!donald.van.dijk@tebu:bio.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1953!
51:200!
Private!
Molecular!biology,!life!science,!diagnostics.!
E.,coli!and!the!HEK293!cell!line!
Lab!scale.!!Some!in:house!production.!
Donald!van!Dijk,!General!Manager!
Sells!enzymes!from!third!parties!in!addition!to!its!own!
Europe!
NA!
+++!
+!
From!the!company!website:!“With!9!local!offices!in!Europe,!tebu:bio!is!a!European!company!specialised!
in!providing!innovative!reagents!and!laboratory!services!in!Life!Sciences.!!Products!offered:!research!
antibodies,!ELISAs,!Arrays,!Proteins!&!Peptides,!Cell:based!&!Functional!assays,!Primary!cells!&!Media,!
SilenciX!KD!cell!lines,!Molecular!biology,!Biochemicals!(si/shRNA,!Compounds,!Lipid!research!tools).!!Lab!
services:!Protein!production!&!purification!(E.!coli,!HEK293,!yeast.),!Cell!Biology!(cell!amplification!&!
differentiation,!cell:line!engineering)!Molecular!biology!(nucleic!cloning,!sub:cloning),!Bio:assays!(gene!
reporter!&!nuclear!receptor!assays,!outsourcing!of!assays!commercialised!by!tebu:bio).”!
Products:!
Tebu:bio!offers!nearly!2,000!enzyme!offerings.!!Extensive!catalog!for!life!science,!molecular!biology,!and!
epigenetics!enzymes.!!!
!
!
384!
!
!
!!
Tegaferm'Holding'GmbH'
www.tegaferm.com!!
2372!Giesshuebl!bei!Wien!
Schillerstrasse!26!a!
Austria!
Tel:!+43!/2236/205!189!
Fax:!+43!/2236/205!18919!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
Small!
Private!
Most!revenues!from!enzymes!
Distilling,!fruit!juice,!brewing!and!baking,!specialty!enzymes!for!technical!and!
food!applications!
NA!
Bulk,!in:house!production!capability!unlikely!
Theodor!Gams,!Founder!
Distributors:!G.!Keynan!(Israel),!TOO!(Ukraine),!Brenntag!(Russia)!
Russia,!Baltic!states,!EU!
NA!
++!
:!
From!the!company!website:!“Tegaferm!Holding!GmbH!initially!specialized!in!the!distribution!of!enzymes!
to!Russia,!Ukraine!and!the!Baltic!countries.!Due!to!excellent!results,!the!sales!organisation!is!rapidly!
expanding!by!co:operating!with!various!companies,!especially!in!Central:!and!Eastern!Europe,!where!
tegaferm!is!in!a!postion!to!offer!their!enzymes!competitively.!Depending!on!agreements,!tegaferm!sells!
also!directly!to!end:users!in!special!fields!of!enzyme!application.!The!main!industrial!markets!for!
tegaferm!Holding!GmbH!are!distilling,!fruit!juice,!brewing!and!baking,!but!also!specialty!enzymes!for!
technical!and!food!applications!are!supplied.”!
Products:!
Alpha:amylase!
Glucoamylase!
!
385!
!
!
!!
Papain!
Proteases!
Beta:glucanase!
Pectinases!
Lysozyme!
Xylanase!
Phytase!
Cellulase!
Transglutamase!
Catalase!
Invertases!
Bromelain!
!
!
!
!
'
'
!
386!
!
!
!!
Tex'Biosciences'
http://www.texbiosciences.com/!!
“Textan!House"!75,!Fourth!Avenue!
Ashok!Nagar,!Chennai!:!600!083!!
India!
Tel:!+91:44:42988700!
Fax:!+91:44:42988787!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1979!
More!than!200!employees!
Private!
Most!revenues!are!from!enzyme!sales.!
Leather,!animal!feed,!pulp!and!paper,!detergent!and!pharmaceuticals.!
Non:GMO!
R.P!Krishnamachari,!Managing!Director!(CEO)!
NA!
Sells!throughout!Asia,!also!sells!in!Africa!and!Europe.!
NA!
++!
NA!
From!the!company!website:!“Tex!Biosciences!(P)!Limited!evolved!from!its!modest!beginning!as!a!basic!
leather!chemical!manufacturer!in!1979!to!currently!serving!the!industrial!needs!of!Leather,!Poultry,!
Piggery,!Aquaculture,!Pulp!&!Paper,!Detergent!and!Pharmaceutical!markets.!The!Core!Strength!of!Tex!
Biosciences!is!the!high!strain!productivity!(all!Non:GMO)!and!its!superior!formulation!&!application!
technology.!The!organization!takes!pride!in!being!OEM!grass!root!enzyme!manufacturer!and!not!merely!
a!formulator!or!trader!of!enzymes.”!!
Products:!
Proteases!
Lipases!
Xylanases!
!
387!
!
!
!!
Pectinase!
Phytase!
Cellulase!
Amylases!
!
!
!
388!
!
!
!!
The'Seydel'Companies'
www.seydel.com!'
244!John!B.!Brooks!Rd.!
Pendergrass,!GA!30567!
USA!
Tel:!+1:706:693:2266!
Fax:!+1:706:693:2074!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1907!
50+!employees!
Private!
Small!
Textiles!
NA!
Bulk.!!In:house!production!unclear.!
Scott!Seydel,!Sr.,!President!and!CEO!
NA!
NA!
NA!
++!
:!
From!the!website:!“The!Seydel!Companies!is!recognized!around!the!world!as!the!premier!formulator!of!
specialty!process!chemicals!and!is!well:poised!to!enjoy!another!century!of!growth.!The!Seydel!
Companies!develop,!manufacture!and!market!specialty!chemicals!for!the!textile!&!apparel,!paper!&!
packaging,!personal!care,!agricultural,!and!metalworking!industries!and!provide!toll:manufacturing,!
technical!laboratory!and!warehousing!services!at!our!production!facilities!in!Georgia!and!North!
Carolina.”!
Products:!
28!enzymes,!including!formulations!of:!
Laccase,!Amylases,!Cellulases,!Catalase!
'
'
!
389!
!
!
!!
Thermo'Fisher'Scientific'
http://www.thermoscientific.com/!!
81!Wyman!Street!
Waltham,!MA!02454!
USA!
Tel:!+1:781:622.1000!
Tel:!+1:800:678:5599!
Fax:!+1:781:622:1207!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1902!(as!Fisher!Scientific)!
40,000!
Public:!TMO!
Small!
Molecular!biology!!
NA!
Marc!N.!Casper,!President!and!CEO!
NA!
Global!
+++!
++!(large!selection!of!restriction!enzymes)!
:!
From!the!company!website:!“Thermo!Fisher!Scientific!is!an!American!precision!laboratory!equipment!
company!that!was!created!in!2006!by!the!merger!of!Thermo!Electron!and!Fisher!Scientific.!!Thermo!
Scientific!FastDigest!enzymes!are!an!advanced!line!of!restriction!enzymes!that!create!a!new!standard!in!
DNA!digestion.!During!our!30!years!of!restriction!enzyme!research,!we!compiled!one!of!the!largest!
collections!of!restriction!enzyme!producing!bacterial!strains!in!the!industry.”!!
Products:!
Include!176!FastDigest®!restriction!enzymes.!!Include!Phusion!polymerase!and!other!enzymes!from!
Finnzymes!and!Fermentas,!both!of!which!Thermo!bought!in!2010.!
Polymerases'
!
!
390!
!
!
!!
Toyobo'Co.'Ltd.'
http://www.toyobo:global.com/!!
2:8,!Dojima!Hama!2:chome!
Kita:ku,!Osaka!530:8230!
Japan!
Tel:!+81:6:6348:3111!
Fax:!+81:6:6348:3206!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1882!
10,500!employees!
Public:!TYO!
Relatively!small!
Diagnostics.!
Many!
Ryuzo!Sakamoto,!President!and!CEO!
NA!
Global!
+++!
+++!
:!
Toyobo!is!a!group!of!companies!that!together!focus!on!three!general!areas:!Films!and!Functional!
Polymers,!Industrial!Materials,!and!Life!Science.!!In!enzyme!products,!Toyobo!specializes!in!
thermostable!enzymes!for!diagnostic!applications.!
Products:!N:Acetylneuraminic!acid!aldolase,!alkaline!phosphatase,!alkalophilic!proteinase,!ascorbate!
oxidase,!cholesterol!esterase,!cholesterol!oxidase,!choline!oxidase,!creatine!amidinohydrolase,!
creatinine!amidinohydrolase,!creatinine!deiminase,!diaphorase,!formaldehyde!dehydrogenase,!D:
fructose!dehydrogenase,!beta:galacotosidase,!glucoamylase,!glucose!dehydrogenases,!glucose!oxidase,!
glucose:6:phosphate!dehydrogenase,!alpha:glucosidase,!beta:glucosidase,!glutamate!dehydrogenases,!
glycerol!dehydrogenase,!glycerol:3:phosphate!dehydrogenase,!glycerol!kinase,!L:alpha:
glycerophosphate!oxidase,!hexokinase,!p:hydroxybenzoate!hydroxylase,!D:3:Hydroxybutyrate!
dehydrogenase,!invertase,!lactate!dehydrogenase,!lactate!oxidase,!leucine!dehydrogenase,!lipases,!
malate!dehydrogenase,!peroxidase,!pyruvate!oxidase,!pyruvate!kinase,!sarcosine!oxidase,!superoxide!
dismutase,!urease,!uricase,!xanthine!oxidase,!others.!
!
391!
!
!
!!
TransBiodiesel'
http://www.transbiodiesel.com/!!
P.O.Box!437!
Shfar:Am!!20200!
Israel!
Tel:!+972:4:9504523!
Fax:!+972:4:9504525!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2007!
1:10!employees!
Private!
NA!
Immobilized!lipases!for!transesterification!of!oils!and!fats!to!generate!
biodiesel.!!!
NA!
NA!
Sobhi!Basheer,!CEO!and!Founder!
Partnership!with!Purolite!for!the!immobilization!of!lipases.!!At!least!7!scale:
up!trials!undertaken.!
NA!
NA!
+!
NA!
From!the!company!website:!“TransBiodiesel!produces!immobilized!enzyme:based!biocatalysts!for!
production!of!first!and!second!generation!biodiesel!fuels,!complying!with!ASTM!and!EN!specifications.!
Biocatalysts!are!environment:friendly,!and!enable!the!use!of!first!and!second!generation!feedstocks,!
while!lowering!the!total!production!costs!of!biodiesel!fuels.”!
Products:!
!
'
'
!
392!
!
!
!!
TriBTex'Co'(Canada)'
http://www.tritex.com/!!
Tri:Tex!co!inc.!
1001!boulevard!Industriel!
Saint:Eustache,!Qc!!J7R!6C3!
Canada!
Tel:!+1:800:363:2660!!
Tel:!+1:450:974:1001!
Fax:!+1:!450:974:0162!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1938!
Private!
Small!
Textiles!
Trichoderma!and!Bacillus!
Naim!Laham,!CEO!
NA!
NA!
NA!
+!(relatively!small)!
:!
From!the!company!website:!“Tri:Tex's!employees!create!the!basic!chemical!building!blocks!that!go!into!
clothing,!construction!materials,!household!products,!etc.!!Tri:Tex!brings!together!comprehensive!
resources!and!expertise!to!present!our!customers!with!high:quality!chemical!products,!services!and!
solutions.!!Textile!:!Dyes!&!Auxiliaries,!Construction,!Adhesives!&!Coatings,!Acrylic!coatings,!Surfactants!
&!Specialties,!Flooring,!Pigments,!Paper,!Carpet,!Leather.”!
Products:!
Cellulases,!Amylases,!Laccase!
!
!
393!
!
!
!!
Ultra'BioBLogics'Inc.'
www.ublcorp.com!!
24!Sequin!Rigaud!QC,!J0P!1P0!
Canada!!
Tel:!+1:450:451:4195,!450:451:6277!
Fax:!+1:450:451:616!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
NA!
NA!
Private!
Major!portion!of!revenues!from!enzyme!sales!
Animal!feed!enzymes!
Trichoderma,,Aspergillus,,Bacillus,,Chaetomium,,S.,cerevisiae.!!Extraction!
from!papaya!and!pineapple.!
Bulk.!!In:house!manufacture!implied.!
George!Pietras,!President!
NA!
Canada!and!international:!USA,!China,!Portugal,!Mexico.!
NA!
+++!
:!
From!the!company!website:!“Manufacturers!and!suppliers!of!feed!mill!farm!animal!enzymes!phytase,!
xylanase,!cellulase!amylase!supplements!biological!plant!growth!aids!regulators!and!bio!stimulants,!
waste!water!treatment,!food!and!agriculture!waste!and!odor!control!biological!solutions,!biological!
fertilizers!soil!treatment!acidifiers!alkalizers,!golf!course!turf!and!pond!supplies,!alfalfa!hay!preservatives,!
corn!silage!forage!additives!and!inoculants,!septic!tank!and!grease!trap!treatment,!organic!
environmentally!friendly!non!toxic!portable!toilet!sanitizers!cleaners!deodorants,!new!septic!tank!tablets!
fizzytabs,!fiztabs,!dairy!beef!cattle!horn!fly!control,!new!water!soluble!poultry!and!swine!enzymes,!farm!
animal!insect!control,!animal!health!and!nutrition!feed!supplements,!horse!care!health!and!nutrition!
supplements,!products!for!beef!cattle,!dairy,!ultra!natural!plus!poultry!swine!enzyme!formulations.”!
Products:!
Xylanases!
Phytases!
!
394!
!
!
!!
Pectinase!
Proteases!
Galactosidase!
Amyloglucosidase!
Alpha:amylases!
Beta:glucanase!
Bromelain!
Papain!
Cellulases!
Lactase!
Hemicellulase!
Dextranase!
Glucose!oxidase!
Invertase!
!
!
'
'
!
395!
!
!
!!
Unikbio'Biotech(Guangzhou)'Ltd'
www.unikbio.com!!
!#7!Nan!Yun!Wu!Road,!Science!City!
High!and!New!Technology!Industrial!Development!Zone!
Guangzhou!510663!
China!
Tel:!+86:20:32016813!!!!!!!!!
Fax:!+86:20:32016817!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
Small!
Private!
Major!revenue!source!
Brewing,!fruit!and!vegetable,!baking,!pulp!and!paper.!
NA!
Bulk.!!Blender!and!supplier,!no!in:house!production!
NA!
NA!
NA!
NA!
+!
:!
From!the!website:!“Unikbio!Biotech(Guangzhou)!Ltd.,!a!leading!enzyme!manufacturer!and!supplier!in!
China,!which!authenticated!as!High!and!New!Technology!Enterprise!by!Guangdong!Government.!We!
supply!bulks!of!enzyme!products!to!grain!process,!animal!feed,!paper!pulp,!textile!and!other!industries,!
furthermore,!supply!specialized!enzyme!preparations!and!blend!enzymes!to!food!industries,!including!
(brewing,!fruit!and!vegetable!process,!baking,!proteolysis,!plant!extraction),!light!chemical!industry!and!
pharmaceuticals!industry.”!
Products:!
Not!specified.!!!
!
!
396!
!
!
!!
Unitaka'
http://www.unitika.co.jp/!!
4:1:3!Kyutaro:machi!
Chuo:ku,!Osaka,!541:8566!!
Japan!!
Tel:!+81:6:6281:5695!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1889!
Large!global!corporation!
Public:!UTN!
Very!small!
Diagnostics,!biocatalysis.!
Mostly!thermophilic!organisms!
Kenji!Yasue,!President!and!CEO!
NA!
Global!
+++!
++!!
!
Unitaka!is!a!large!Japanese!group!of!companies!that!broadly!target!polymers!and!fibers,!advanced!
materials,!chemicals,!and!health!and!medical!products.!
Products:!
Unitaka’s!enzyme!list!is!broad!and!includes!mostly!products!isolated!from!thermophilic!organisms!with!
enhanced!thermostability,!purity,!and!storage!shelf!life:!!
Acetate!kinase!
Adenylate!kinase!
Alanine!dehydrogenase!
Alanine!racemase!
Diphorases!
!
397!
!
!
!!
Galactose!dehydrogenase!
Glucokinase!
Glucose!hydrogenase!
Alpha:glucosidase!
D:lactate!dehydrogenase!
Leucine!dehydrogenase!
Mutarotase!
Phenylalanine!dehydrogenase!
Phosphofructokinase!
6:Phosphogluconate!dehydrogenase!
Phosphoglucoisomerase!
Phosphoglycerate!kinase!
Phosphotransacetylase!
Polynucleotide!phosphorylase!
Pyruvate!kinase!
Sorbitol!dehydrogenase!
!
!
!
398!
!
!
!!
VEMO'99'Ltd'&'VSV'Ltd!
http://www.vemo:vsv.com/!!
13!Shumen!str.!
1309!Sofia!
Bulgaria!
Tel:!+359!2!931!66!21!
Tel/Fax:!+359!2!931!10!91!
Email:!info@vemo:vsv.com;!info@vemo:feedadditives.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1999!
11:50!employees!
Private!
Animal!feed!and!baking.!
NA!
!Bulk.!!In:house!production.!
Hristo!Zlatev!and!Nina!Zlateva,!Founders!
NA!
NA!
NA!
+!
NA!
“VEMO!99!Ltd!was!founded!in!1999,!with!administrative!center!in!Sofia,!Bulgaria,!is!a!producer!of!
standardised!herbal!extracts,!biologically!active!nutritional!supplements,!plant!and!enzyme!feed!
additives.!The!herbal!nutritional!supplements!and!feed!additives!are!based!on!proprietary!company!
produced!extracts!from!rare!Bulgarian!remedial!plants.!The!closed!production!cycle!guarantees!full!
technological!and!analytical!control!of!the!produced!phyto!products.!In!the!composition!of!the!enzyme!
premixes!are!included!highly!purified!enzymes!with!guaranteed!quality.”!
Products:!
Phytases!
Amylases!
Cellulases,!Hemicellulases!
!
!
399!
!
!
!!
Verenium'(now'part'of'BASF)'
www.verenium.com!!
3550!John!Hopkins!Ct.!
San!Diego,!CA!92121!
USA!
Tel:!+1:800:523:2990!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1992!(first!as!Industrial!Genome!Science,!then!as!Diversa)!
111!employees,!$50!million!in!revenues!
Public,!stock!symbol!VRNM,!being!acquired!by!BASF!
Nearly!all!sales!are!enzymes,!some!collaborative!R+D!revenue!additional!
Animal!fee,!oil!field,!biofuels,!pulp!and!paper,!textiles.!!
Many!
Verenium!leases!facilities!from!Fermic!in!Mexico!to!manufacture!on!a!multi:
ton!scale,!pilot!facilities!are!in!San!Diego!CA!USA!
James!Levine,!President!and!CEO;!Janet!Roemer,!Exec.!VP!and!COO!
DuPont,!Novus,!Tate!and!Lyle,!Weiss!Biotech,!Cargill!
Global!
+++!(not!profitable!on!its!own,!Verenium!will!be!backed!by!BASF’s!excellent!
financial!health)!
++!(about!10!enzymes)!
:!
Verenium!has!collected!one!of!the!most!comprehensive!libraries!of!environmental!DNA.!!This!DNA!is!
expressed!in!recombinant!hosts,!and!Verenium!can!screen!on!the!order!of!a!million!enzymes!per!day!
using!its!custom:developed!high:throughput!platform.!!The!company!finds!enzymes!in!its!collection!and!
optimizes!them!using!directed!evolution!for!commercial!uses!in!feed!and!food,!oil!field!processing,!
textiles,!and!first!generation!grain!processing!for!biofuels.!!Due!to!its!access!to!DNA!from!unique!or!rare!
sources,!Verenium’s!enzymes!are!often!significantly!differentiated!from!competitors’!offerings.!!This!
differentiation!means!that!Verenium,!despite!its!small!size,!can!often!compete!with!the!larger!industrial!
biotechnology!firms.!!The!company!formerly!had!a!joint!venture!with!BP!in!biofuels,!and!Verenium!sold!
its!share!of!the!business!to!BP.!!!
In'September'of'2013,'BASF'announced'that'it'would'acquire'Verenium.!!The!acquisition!was!ex[ected!
to!be!complete!by!the!end!of!2013.!BASF!will!likely!continue!to!offer!Verenium’s!current!selection!of!
catalog!enzymes,!and!will!likely!end!collaborative!R+D!efforts!with!third!parties.!
!
400!
!
!
!!
Products:!
Phyzyme®!XP!Phytase!(Animal!Health!&!Nutrition)!
Fuelzyme®!Alpha:amylase!(Grain!Processing!–!Fuel!Ethanol)!
Deltazym®!GA!L:E5!Glucoamylase!(Grain!Processing!–!Fuel!Ethanol)!!
Deltazym®!APS!Protease!(Grain!Processing!–!Fuel!Ethanol)!!
Xylathin®!Xylanase!(Grain!Processing!–!Fuel!Ethanol)!
Pyrolase®!Cellulase!(Oilfield!Services!–!Hydraulic!Fracturing)!
Pyrolase®!HT!Cellulase!(Oilfield!Services!–!Hydraulic!Fracturing)!!
Eradicake®!Alpha:amylase!(Oilfield!Services!–!Mudcake!Removal)!!!
Luminase®!PB:100!Xylanase!(Industrial!Processes!–!Pulp!&!Paper)!!
Cottonase®!Pectate!lyase!(Textiles)!
'
'
!
401!
!
!
!!
Veskim'
www.veskim.com!!
KARAOĞLANOĞLU!CAD!
ETEM!ZENGİN!İŞ!MERKEZİ!KAT:5!!
NO:25!SEYRANTEPE/İSTANBUL!
Turkey!
Tel:!+90!212!283!10!17!
Fax:!+90!212!282!80!38!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1987!
51:100!employees!
Private!
Very!small!
Textiles!
None!
NA!
NA!
NA!
NA!
+!
:!
The!company!imports,!produces,!exports,!and!markets!chemicals!in!food,!leather,!agriculture,!and!
textiles.!
Products:!
Enzymes!for!stonewashing!and!desizing,!likely!cellulases!and!amylases.!
!
!
!
!
402!
!
!
!!
!
W42'Industrial'Biotechnology'GmbH'
http://www.w42biotechnology.de/!!
Lipper!Weg!192!
45772!Marl!
Germany!
Tel:!+49!(0)2365!9246772!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2005!
About!5!employees!
Private!
Biocatalysis!
Pichia,,Streptomyces,,and!E.,coli,
Likely!small!
Ansgar!Stratmann,!Managing!Director!(CEO)!
Vibalogics!has!entered!into!an!exclusive!partnership!with!W42!Industrial!
Biotechnology!for!the!provision!of!protein!production!using!the!expression!
system!Pichia!pastoris.!!Jiaozuo!Joincare!Biotechnological!Co.,!Ltd.!is!a!scale:
up!partner!for!W42’s!soluble!and!immobilized!enzymes!up!to!a!ton!scale.!!
Company!uses!materials!from!Resinion!(a!Mitsubishi!company)!for!
immobilization!efforts.!
NA!
NA!
+!
+!
W42!is!an!expert!at!protein!expression!in!Pichia,!and!it!both!licenses!out!this!platform!and!uses!it!for!
protein!expression!development!for!customers.!!It!also!has!a!small!catalog!of!enzymes!and!immobilized!
enzymes!for!sale.!!It!offers!contract!research!for!expression!of!proteins!in!Pichia!and!E.,coli,!for!
developing!biocatalysts,!and!for!enzyme!production!development.!
!
!
!
403!
!
!
!!
Products:!
Immobilized!and!soluble!versions!of:!
Penicillin!G!acylases!
Penicilin!G!amidases!
Lipases!
D:hydantoinases!
!
!
'
'
!
404!
!
!
!!
Wako'Pure'Chemical'Industries,'Ltd.'
http://www.wako:chem.co.jp!! !
1:2!Doshomachi!3:Chome!
Chuo:ku,!Osaka!540:8605!
Japan!
Tel:!+81!(6)!2033741!
Email:!cservice@wako:chem.co.jp!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1922!
1500!employees!
Private!
Small!
Diagnostics.!
NA!
Lab!scale.!!In:house!production!likely.!
Shinzo!Kobatake,!President!
Wako!sells!enzymes!from!third!parties!as!well!as!its!own!
Global.!!Based!in!Japan,!the!company!also!has!offices!and!distributes!in!the!
USA!and!other!countries.!
+++!
++!
:!
Wako!sells!a!large!range!of!laboratory!chemicals,!specialty!chemicals!and!diagnostic!reagents.!!This!large!
organization!sells!globally!but!especially!in!Japan,!USA,!and!Germany.!!!
Products:!
Beta:agarase!
Phosphatases!
Aldose!reductase!
Collagenase!
Creatine!kinase!
!
405!
!
!
!!
Proteases!
Beta:galactosidase!
Lipases,!soluble!and!immobilized!
Natto!kinase!
Trypsin!
!
!
!
!
!
'
'
!
406!
!
!
!!
WeissBioTech'GmbH'
http://www.weissbiotech.com/!!
An!der!Hansalinie!48:50!
D:59387!Ascheberg!
Germany!
Tel:!+49!(0)!2593!919!386!
Fax:!+49!(0)!2593!919!393!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
2002!
NA!
Private!
Significant!contributor!
Biofuels,!starch!processing,!fruit!juice,!dairy,!meat,!brewing.!
NA!
NA!
Verenium!is!the!manufacturer!of!most!of!the!enzymes!
NA!
NA!
+!(small)!
:!
WeissBiotech!is!a!distributor!of!Vernium!enzymes,!and!sells!yeast!nutrient!and!dairy!additives!as!well.!!!
Products:!
Alpha:amylase!
Glucoamylases!
Beta:glucosidase!
Proteases!
'
'
!
407!
!
!
!!
Worthington'Biochemical'Corporation'
www.worthington:biochem.com!!
730!Vassar!Ave!
Lakewood,!NJ!08701!
USA!
Tel:!+1:800:445.9603!or!+1:732:942:1660!!
Fax:!+1:800:368:3108!or!+1:732:942:9270!
Email:!custservice@worthington:biochem.com!!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1947!
50:100!employees!
Most!sales!are!enzymes.!
Biocatalysis,!diagnostics,!molecular!biology,!life!sciences.!
Extraction!from!animal!and!plant!tissue,!and!microbial!fermentation.!
Lab!scale!to!bulk.!!In:house!production.!
Von!Worthington,!President!
NA!
Distributors!in!28!countries,!universities,!commercial!users.!
++!
+++!
:!
Worthington!is!a!manufacturer!and!supplier!of!a!large!number!of!enzymes!and!proteins.!!The!company!
has!been!around!a!long!time!and!supplies!enzymes!that!a!number!of!other!companies!sell!retail.!!The!
company!also!sells!small!amounts!directly!to!primary!users.!
Products:!!
Actin;!DNA!Ligase,!T4;!Nuclease,!S1;!Adenosine!Deaminase;!DNA!Polymerase!I;!Nucleohistone;!Albumin,!
Nuclease:Free;!DNA!Polymerase!I,!Klenow!Fragment;!Ovalbumin;!Alcohol!Dehydrogenase;!DNA!
Polymerase,!Taq;!Oxalate!Decarboxylase;!Aldolase;!DNA!Polymerase,!T4;!Papain;!Amino!Acid!Oxidase,!D:
;!Elastase;!Papain!Dissociation!System;!Amino!Acid!Oxidase,!L:;!Elastin;!Papain,!Chymo;!Amylase,!Alpha;!
Galactose!Oxidase;!Pectinase;!Amylase,!Beta;!Galactosidase,!Beta;!Pepsin;!Arginase;!Glucose!Oxidase;!
Peroxidase;!Asparaginase;!Glucose:6:Phosphate!Dehydrogenase;!Phosphatase,!Acid;!Aspartate!
Aminotransferase;!Glucosidase,!Beta;!Phosphatase,!Alkaline;!Avidin;!Glucuronidase,!Beta;!
!
408!
!
!
!!
Phosphodiesterase!I;!Beta!Agarase;!Glutamate!Decarboxylase;!Phosphodiesterase!II;!Carbonic!
Anhydrase;!Glyceraldehyde:3:Phosphate!Dehydrogenase;!Phosphoenolpyruvate!Carboxylase;!
Carboxypeptidase!A;!Glycerol!Dehydrogenase;!Phosphoglucomutase;!Carboxypeptidase!B;!Glycerol!
Kinase;!Phospholipase!A2;!Carboxypeptidase!Y;!Hemoglobin;!Phospholipase!C;!Casein,!Alpha;!
Hepatocyte!Isolation!System;!Plasma!Amine!Oxidase;!Catalase;!Hexokinase;!Pokeweed!Antiviral!Toxin;!
Cell!Isolation!Optimizing!System;!Histones;!Polynucleotide!Kinase,!T4;!Cellulase;!Hyaluronic!Acid;!
Polyphenol!Oxidase;!Cholesterol!Esterase;!Hyaluronidase;!Protease,!Staph!aureus!(Endoproteinase!Glu:
C);!Cholinesterase,!Acetyl;!Hydroxysteroid!Dehydrogenase;!Proteinase!K;!Cholinesterase,!Butyryl;!Lactate!
Dehydrogenase;!Pyruvate!Kinase;!Chymotrypsin;!Lactate!Dehydrogenase,!L:!(Cytochrome!b2);!Reverse!
Transcriptase,!Recombinant!HIV;!Chymotrypsinogen!A;!Lactoperoxidase;!Ribonuclease!A;!
Clostridiopeptidase!A;!Leucine!Aminopeptidase;!Ribonuclease!B;!Clostripain!(Endoproteinase:Arg:C);!
Lipase;!Ribonuclease!T1;!Collagen;!Luciferase;!Ribonuclease,!E:Rase™!RNase!Blend;!Collagenase;!
Lysozyme;!Ribonucleic!Acid;!Collagenase!(Animal!Origin!Free);!Malate!Dehydrogenase;!RNA!Polymerase;!
Collagenase/Neutral!Protease!(STEMzyme™);!Maltase;!RNA!Polymerase,!T7;!Concanavalin!A;!
Micrococcus!lysodeikticus!Cells;!Superoxide!Dismutase;!Creatine!Kinase;!Mucin;!Trypsin;!Cytochrome!C!
Oxidase;!Myoglobin;!Trypsin!Inhibitors;!Deoxyribonuclease!I;!NADase!(DPNase);!Trypsinogen;!
Deoxyribonuclease!I,!Recombinant,!AOF;!Neonatal!Cardiomyocyte!Isolation!System;!Tyrosine!
Decarboxylase;!Deoxyribonuclease!II;!Neuraminidase;!Urease;!Deoxyribonucleic!Acid!and!Related!
Products;!Neutral!Protease!(Dispase);!Uricase;!Dextranase;!Nitrate!Reductase;!Xanthine!Oxidase!.!
!
!
!
'
'
!
409!
!
!
!!
Yakult'Pharmaceutical'Industry'Co.,'Ltd.'
http://www.yakult.co.jp/ypi/en/!!
1796!YAHO,KUNITACHI:SHI!
Tokyo!186:8650!!
Japan!
Tel:!+81:42:577:8967
!
Fax:!+81:42:573:1682!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1986!
NA!
Private!
Food,!brewing,!animal!feed,!life!sciences.!
Aspergillus,,Rhizopus,,Bacillus,,Streptomyces,,Trichoderma,!etc.!
Bulk.!!In:house!production.!!!
Chizuka!Kai,!President!
NA!
NA!
NA!
++!
:!
Though!known!for!its!yogurt!business,!Yakult!makes!and!sells!food!enzymes!in!this!business!unit.!
Products:!
Cellulases!
Pectinases!
Hemicellulases!
Collagenase!
Proteases!
Glucoamylases!
!
410!
!
!
!!
Alpha:amylases!
Lipase!
Lactase!
!
!
'
'
!
411!
!
!
!!
Zymetech'
www.zymetech.com!!
Kringlan!4:12103!Reykjavík!
Iceland!
Tel:!+354!551!5400!
Fax:!+354!551!5402!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
!
1997!
1:10!employees!
Private!
Majority!of!revenues!are!enzyme!sales!
Medical,!cosmetical.!
Extraction!from!animal!tissue!(Codfish,!Gadus,morhua)!
Relatively!small!
Sigrún!Gísladóttir,!Managing!Director!
Andrá,!Iceland!
Enzymatica,!Sweden!
Alvogen,!Iceland!and!China!
Pure!Icelandic,!UK!
FACE!Stockholm,!USA!and!Sweden!
ICE!Serum!International!ApS!,!Denmark!
Sells!through!partners!
NA!
+!
:!
From!the!company!website:!“Zymetech!develops!medical!devices!aimed!at!treating!various!medical!
indications.!Our!specific!formulations!in!combination!with!purified!marine!proteases!(Penzyme)!have!
beneficial!effects!on!the!body!when!applied.”!
Products:!
Cold:active!proteases!(trypsin)!
!
'
'
!
412!
!
!
!!
Zytex'
www.zytex.com!!
Polaris,!6th!floor,!Off.!Marol!Maroshi!Road!
Behind!Sangeet!Plaza,!Marol,!Andheri!(East)!
Mumbai!:!400!059!
India!
Tel:!+91:22:6772!3000!
Fax:!+91:22:6725!3399!
Year!Founded!
count!or!both)!
Company!type!
of!company!sales!
Enzyme!categories!
Expression!systems!
Capacity/scale!
Key!People!
Partnerships!
Customers!
Financial!Health!
Catalog!of!Enzymes!
Toll!Manufacturing!
1996!
51:200!employees!
Private!
Small!
Textiles!
NA!
Bulk.!!Some!in:house!production.!
NA!
BBI!Enzymes,!U.K.!
Boval!Company,!U.S.A!
Dishman!Netherlands!B.V.!(formerly!Solvay)!
Giovanni!Bozzetto!S.p.A.,!Italy!
Hydro:Thermal!Corp.,!U.S.A!
Kem:en:tec,!Denmark!
Lallemand!/!Institut!Rosell,!Canada!!
Meiji!Co.,!Ltd.,!Japan!
Novozymes!A/S,!Denmark!
Organo!Technie!S.A.,!France!
Toyo!Science!Corp.,!Japan!
Unilever,!Netherlands!
Worthington!Biochemical!Corporation,!U.S.A!
partner!for!Unilever's!Global!Enzyme!Analytical!Lab!for!their!home!care!
division!supporting!more!than!65!factories!and!labs!around!the!world!
In!14!countries.!!Notable!companies!include!Nestle!and!Heinz.!
NA!
+!
+!
!
413!
!
!
!!
!
Zytex!is!a!manufacturer,!importer,!and!distributor!of!textile!enzymes,!nutraceuticals,!sweetners,!
cosmeticals,!baking!aditives,!fertilizers,!pharmaceuticals,!diagnostics,!and!animal!feed!aditives.!!
Additionally,!Zytex!has!an!enzyme!analysis!business.!!!
Products:!
Undisclosed!textile!enzymes.!!Likely!cellulases,!amylases,!laccase,!and!catalase.!!
!!!
!
!
!
!
!
!
!
!
!
!
414!
!
!
!!
Distributors'Lists'
Lists!of!distributors!were!compiled!from!lists!that!enzyme!suppliers!provided.!!Some!may!carry!enzymes!
as!a!major!part!of!their!offerings,!while!for!others!enzymes!may!represent!only!a!small!part!of!their!
ocerall!product!offerings.!Although!the!large!group!of!company!profiles!also!includes!distributors,!those!
listed!here!were!deemed!to!be!smaller!in!scale!and!less!focused!on!enzymes.!
!
Distributors'Carrying'Animal'Feed'Enzymes'
!
3'F'Food'&'Feed'S.L.'
Avda!Rey!Juan!Carlos!
I,!98:2°C!
ES:28916!Léganes!
Spain!
Tel:!+34!/!914987466!
Fax:!+34!/!914810544!
Mr.!Juan!Gálvez!del!Hierro!
!
!
A.T.S.'Advanced'Technology'Supplise'A.T.S.'A.S.'
Att:!Can!ÇAGLAYAN!
Turkey!
Tel:!+90!(212)!287!32!50!
Fax:!+90!(212)!287!66!33!
GSM:!+90!(533)!714!45!80!
!
!
415!
!
!
!!
!
A/S'"Dimela'Veta'Latvija",'"Eziši"'
Marupes!pag.!
Rigas!raj.!
LV:2166,!Ezisi!
Latvia!
Tel:!+371!67610001!
Fax:!+371!6780!7830!
Mrs.!Vita!Bude!
!
!
AddBCo'Nutrition'srl'
Massimo!Neri!
via!Carducci,!18!
20123!–!Milano!
Italy!
Tel:!+39:0542!67!02!43!
!
!
Aditmaq'
Vicente!Duque!N73:85!y!Jose!de!la!Rea!!
Quito!
Ecuador!
!
416!
!
!
!!
Tel:!+593!2!2477471!
!
!
Alivet'
Rua!Severino!José!de!Paula,!338!–!Piedade!
Jaboatão!dos!Guararapes!–!PE!
Brazil!
Tel:!+55!81!3342!5422!
!
!
Almoner'Store'Hama'Syria'
Hama!:!Syria!:!AL:Barodiah!Street!
P.O!Box!612!
Hama!
Syria!
Tel:!+96!333210887!
Fax:!+96!333210218!
Dr.!Ahmad!Assar!
!
!
AMMCO'PHARMA'SAÚDE'ANIMAL'LTDA.'
Av.!Pedro!Hereman,!35!!
!
417!
!
!
!!
Centro!!
13165:000!Engenheiro!Coelho!!
Sao!Paulo!SP!
Brazil!
Tel:!+55!19!2105:9462!
!
!
Anmel'Agro'Sdn'Bhd.'
295,!Jalan!2/62!
Bandar!Menjalara!
52200!Kuala!Lumpur!
Malaysia!
Tel:!+60!3!62748067!
!
!
Apsa'Internacional'SA'
Int.!Juan!Lumbreras!1800!!
Gral.!Rodriguez!(CP!1748)!Bs.As.!
Argentina!
Tel:!+54:0237:485:7300!
www.apsanet.com.ar!
'
'
!
418!
!
!
!!
ARTAT'Enterprise''
Al:Hasan!Bin!Ali!Street!Bldg#4!!
Riyadh!11675!
Saudi!Arabia!!
Tel:!+966!1!492!2288!!
Fax:!+966!1!497!2459!!
Emai:[email protected]!!
www.artat.com.sa!!
!
!
Aryadalman'Co.'
Unit!4:No.15,!Meftah!Alley,!
South!Sheikh!Bahaie!St.,!Molasadra!Ave!
IR:11369!Tehran!
Iran!
Tel.:!+98!2188033063!(Ext:109)!
Fax:!+98!2188617296!
!
!
Ascot'International'
veterinary!products!&!animal!health!dept.!
Cité!170!logts!bt1!local!12!
Rouiba!
Algeria!
!
419!
!
!
!!
Tel:!+213!21!81!54!74!
!
!
Auster'Nutrição'Animal'Ltda'
Estrada!Municipal!Cobrasma,!50!
Bairro!Industrial!Delta!
Hortolândia!:!SP,!13.185:000!
Brazil!
Tel:!+55!(19)!3865!9599!
www.austernutri.com.br!
!
!
BELMARC'
Mr.!Leo!Noppe!
30!Bd!Abdellatif!Ben!KADDOUR!
Casablanca!
Morocco!
Tel:!+212!661!332!282!
Fax:!+212!522!279!642!
!
!
Besta'Biotech'Co.'Ltd.'
!
420!
!
!
!!
7Fl.,!No.!54,!Sung!Chiang!Road!
Taipei!10456!
Taiwan!ROC!
Tel:!+886!2!25811628!
!
!
Bill'Barr'and'Company'
8800!Grant!Ave.!
Overland!Park!KS!66212!
USA!
Tel:!+1:800:336:BARR!
Fax:!+1:913:599:0425!
www.billbarr.com!
!
!
Bioferm'CZ,'spol.'s'r.o.'
Banskobystricka!55,!621!00!Brno!
Czech!Republic!
Tel:!+420!541!422!550,!+420!545!247!600!
!
!
BioGem'Ltd'
#238!Color!Hill!Building!
897!Pyungchon:dong!
!
421!
!
!
!!
Dongan:ku,!Anyang:si!
Kyunggi:do!(431:070)!
Korea!!
Tel:!+82!31!4236606!!
!
!
Biosapien'
Al!Quoz!!
1!Dubai,!34206!
United!Arab!Emirates!!
Tel:!+971:50:2927128!
!
!
BIOSMART'COMPANY''
Dr.!Yasser!Abul!Soud!!
1!bank!Eleskan!buildings!
Elmehwar!Elmarkazy!
6th!October!City!
Egypt!!
Tel:!+20110005878!
!
!
BuffaloBWarren'Company'
!
422!
!
!
!!
P.O.!Box!220099!
Charlotte,!North!Carolina,!28222:0099!
USA!
Tel:!+1:704:366:5763!
!
!
C2Mix'Nutrition'Animale'
70,!Angle!Rue!Libourne!et!Boulevard!de!la!Résistance!(6ieme!etage)!
Casablanca!
Morocco!
Tel:!+212!522541111!
Fax:!+212!522541102!
Dr.!Mohamed!Berrada!
!
!
Çelik'Veteriner'Ürünleri'
Danismanlik!Gida!Paz.!!
San.!ve!Tic.!Ltd.,!Sti.!!
Turgut!Reis!Mahallesi!Fatih!Bulvarı!No:328!
Sultanbeyli/Istanbul!
Turkey!
Tel:!+90!/!216!/!598!01!15!
Fax:!+90!/!216!/!598!01!16!
!
423!
!
!
!!
!
!
Central'Agricola'S.A.'de'C.V'
Calzada!Atanasio!Tzul!22:00,!Zona!12!
Empresarial!El!Cortijo!II!
Bodega!120!C.A.!01012!
Guatemala!
Tel:!+502!2327:0340!
!
!
Cerpol'
ul.!Staniewska!16!
63:720!Kozmin!WLKP!!
Poland!
Tel:!+48!62!721!6826!
www.cerpol.net.pl!
!
!
Chr.'Olesen'Nutrition'A/S'
Pieter!Hillebrand!
Jægersborg!Allé!164!
DK:2820!Gentofte!
!
424!
!
!
!!
Denmark!
Tel:!+31!653201198!
Email:!ph@chr:olesen.dk!
!
!
Country'Vet'Wholesaling'Pty'Ltd'
144!Murphy!St.!
Bendigo!VIC!3550!
Australia!
Tel:!+61!/!0!/!1800!426!142!
Fax:!+61!/0!/!03!5442!6119!
!
!
Dakovit'Ltd'
Rákóczi!út!8,!Pf.59!
2943!Bábolna!
Hungary!
Tel:!+36!34!568!470!
Fax:!+36!34!568!479!
!
!
DCL'Nutrition'and'Animal'Health'
6340,!Choquette,!Saint:Hyacinthe!
!
425!
!
!
!!
Canada!
Tel+!+1!450!773!0770!
www.dcli.ca!
!
!
DENBGE'ECZA'DEPOSU'SAN.'ve'TİC.'LTD.'ŞTİ.'
Arabacı!Alanı!Mahallesi!M.!Akif!Ersoy!Caddesi!No:!18/A!
Adapazarı!/!SAKARYA!
Turkey!
Tel:!+90!/!!264!/!279!35!33!!
Fax:!+90!/!264!/!279!35!34!
www.kanatliilaclari.com!
!
!
Disan'
Autopista!Medellin!(Calle!80),!km!1,6!
Costado!Norte!
Bogota!
Colombia!
Tel:!+571!587!7788!
!
!
Egavet'
106,!King!Faisal!Street!
!
426!
!
!
!!
Giza!
Egypt!
Tel:!+202!33!83!7138!
!
!
Eigenmann'and'Veronelli'
Via!Della!Mosa!
6!:!20017!RHO!(MI)!
Italy!
Tel:!+39!02!93539!303!
www.eigver.it!
!
!
El'Badra'International'Company'for'Agri.'Contracting'LTD.'
P.O.!Box!784!Al!Safah!
Mariam!commercial!complex,!office!#!16!
81000!Kuwait!
Kuwait!
Tel:!+965!050513598!
Fax:!+965!051147743/:4739002!
!
!
Encipharm'Ltda'
!
427!
!
!
!!
Av.!Irarrazaval!5185!!
410,!Nunoa!
Santiago!
Chile!
Tel:!+56!2!2263086!
!
!
Farmwealth'Enterprise'Co'Ltd'
No!32,!Alley!22,!Lane!619!
Chung!Hua!Road!
710!Yung!Kang!City!
Tainan!Hsien!
Taiwan!
Tel:!+886!6!2014609!
!
!
Flavor'Corporation'of'Korea'
236:11!JungKok:Dong!
Gwang!Jin:Ku,!Seoul!
KR:143:223!Seoul!
Korea!
Tel:!+82!/!0!/!2!466:9227!
Fax:!+82!/!0!/!2!466:7817!
!
428!
!
!
!!
!
!
Ghazi'Brothers'
Ghazi!House!D:35!
KDA!Scheme!No!1!
Miran!Muhammad!Shah!Road!
Karachi!:!75350!
Pakistan!
Tel:!+9221!111!250!365!
!
!
GlobalVet'
CALLE!MARIO!VALDIVIA!No!180!
URB.!MARANGA!III!ETAPA!!
San!Miguel!
Lima!
Peru!
Tel:!+51!719:0377!
!
!
Hedab'Institution'for'Veterinary'Drugs'
King!Husain!Street!Crossing!
!
429!
!
!
!!
JOR:13110!Jordan:Zarka!
Jordan!
Tel:!+96!/!25!/!3930552!
Fax:!+96!/!25!/!3980030!
Dr.!Nabeel!Al!Luobani!
!
!
Indukern'de'México'
CP.!45019!
Zapopan,!Jalisco!!
México!
Tel:!+52!33!37:77:43:43!
Fax:!+52!33!37:77:43:45!
www.indukern.com.mx!
!
!
Inoza'Industries,'Inc.'
179!Mariano!Ponce!Street!
PH:1400!Caloocan!City,!MetroManila!
Philippines!
!
!
Interpharma'Egypt'Co.'
!
430!
!
!
!!
1!Ellewa!Abd!El:Aziz!Ali,!Al!Mohandes!Tower!
EG:!Zagazig!
Egypt!
Tel:!+20!552!325:801!
Fax:!+20!552!338:946!
Email:!ipc@interpharma:egy.com!
!
!
Inversiones'Toledo'S.A.'
Calzada!Atanasio!Tzul!22:00,!Zona!12!
Empresarial!El!Cortijo!II,!
Bodega!120!C.A.!01012!
Guatemala!
Tel:!+502!2327:0340!
!
!
Invivo'NSA,'SA'
Zona!Industrial!de!Murtede!
3060:372!Murtede!
Portugal!
Tel:!+35!/!1231209900!
Fax:!+35!/!1231209909!
Email:!caguiar@invivo:nsa.pt!
!
!
431!
!
!
!!
!
Julia'Brandt'Plus'
Dostyk!avenue,!house!44,!apartment!69!
KZ:050010!Almaty!
Kazakhstan!
Tel:!+7!727!279!99!71!
Fax:!+7!727!279!71!66!
www.ybp.kz!
!
!
KIMIA'DAROU'MEHR'(PJS)'
Kalantari!Ali!Reza!(DVM)!
General!Manager!
Unit!6,!No.!146,!Gisha!Ave!
Tehran!1447683385!
!Iran!
Tel:!+98!21!88245436!/!37!
Fax:!+98!21!88287753!
!
!
Kubbar'International'Co.'for'Import'&'Export''
Sahoud!Commercial!Complex!
Hawally,!Block!1!
!
432!
!
!
!!
Street!17,!Building!14610,!Fifth!Floor!
Kuwait!
Tel:!+965!22619!404!!
www.kubbarintl.com!
!
!
Lemart'
Paseo!del!Ocaso!249:272!A!
Villas!de!Irapuato!
Irapuato!Gto!36670!
Mexico!!
Tel:!+52!462!623!1333!
[email protected]!
!
!
Lins'Company'(Cong'ty'Hoa'sen)'
7th!Floor,!Block!B,!HDTC!Building!
36!Bui!Thi!Xuan!Street!
Ben!Thanh!Ward,!District!1,!HCMC!
Vietnam!
Tel:!+84!8!39259356!Fax:!+84!8!39259355!
Emails:[email protected],[email protected]!
!
!
!
433!
!
!
!!
Lon'Green'
5F:1,!No.450!Jhengher!South!Rd.!
Chienjen!District.!Kaohsiung!806!
Taiwan!R.O.C.!
Tel:!+886!937!366443!
Fax:!+886!7!537!3386!
!
!
Lotra'Co'
Suite!5,!2nd!Floor!
Bldg!No.10!
8th!St.!Vozara!Ave!
Tehran!15117!
Iran!!
Tel:!+98!21!88704817!/!8!
!
!
M/S'Vet.Pharma'Trading'Company'
Dr!Ahmad!Naseem!Goraya!
New!Steel!Market!Near!Reagent!Cinema!
G.T.!Road!Gujranwala!
Pakistan!
Tel:!+92553258805.3732016!
!
434!
!
!
!!
Emails:[email protected],[email protected]!
!
!
Mazzoleni'Prodotti'Zootecnici'S.P.A.'
Via!dell'Artigianato,!77/81!
24055!Cologno!al!Serio!(BG)!
Italy!
Tel:!+39!354183301!
www.prodotti:zootecnici.it!
!
!
Medical'Products'Ltd.'
Animal!Health!Division!
54,!G.!Gennimata!Ave.!
GR:16562!Athens!
Greece!
Tel:!+30!/!210!/!9647500!
Fax:!+30!/!210!/!9650500!
!
!
Misma'Ltd.'
Mikhail!Smahliuk!
Polyarnaya!str.!31V,!building!1!!
!
435!
!
!
!!
127282!Moscow!
Russia!
Tel:!+7!495!788!53!90!
!
!
Misr'Feed'Additives'
57,!Abd!Al!Hamid!Badawy!St.!
P.O.!Box:!2399!Al!Horia!
EG:11362!Heliopolis!
Egypt!
Tel:!+202!2624!1132!
Fax:!+202!2621!6590!
!
!
Nassim'Al'Shoara'
PO!Box!53571!
Jeddah!21593!
Saudi!Arabia!
Tel:!+966!2!661!3940!
!
!
Neobio'Co.,'Ltd'
!
436!
!
!
!!
Yeongtong:dong,!Yeongtong:gu,!
KR!:!Gyeonggi:Province!443813!
Korea!
Tel:!+82!/!0!/!312020018!
Fax:!+82!/!0!/!312020409!
!
!
Nicoleta'Lux'S.A.'
str.!Calea!Orheiului!59!
MD:2059!Chisinau!
Moldova!
Tel:!+373!22!459247!
Fax:!!+373!22!467533!!
www.nicoleta:lux.md!
!
!
Noack'
Auhofstraße!190!
1130!Vienna!
Austria!!
Tel:!+43:1:877!5455:0!!
Fax:!+43:1:876!5443!!
!
437!
!
!
!!
!
!
Nuevo'S.A.'
Leoforos!Stratigou!N.!Plastira!
34600!:!Nea!Artaki!
Evia!
Greece!
Tel:!+30!222!10!400!81!
!
!
NUTRI'ADVANCE'
Andre:Yves!Bourges!
Parc!technologique!du!Zoopole!
18!A!rue!du!sabot!
F:22440!PLOUFRAGAN!
France!
Tel:!+!33!296!765!486!
Email:!contact_us@nutri:advance.com!
!
!
nutriscan'agro'(bd)'limited'
House#!25/5th!Floor!
Road#!07,Sector!#!04!
Uttara,Dhaka:1230!
!
438!
!
!
!!
Bangladesch!
Tel:!8917972,!01915204797,!01678058839!
Fax:8917972!
!
!
Nutrivet'
Nutrivet!Ic!ve!Dis!Tic.!Ltd.!Sti.!!
Mansuroglu!Mah.!295/2!Sok.!No:1!
B!Blok!Kat:2/219!35010!Bayrakli!
Izmir!
Turkey!
Tel:!+90!232!462!35!25!!
www.nutrivet.com.tr!
!
!
Planet'Health'
94!Rue!Annesrine:Hay!Arraha!(Beauséjour)!
Casablanca!
Morocco!
Tel:!+212522369156!
Fax:!+212522948659!
!
!
!
439!
!
!
!!
PROFEED'
Mr.Cristian!Burlacu!
Bd.!Libertatii!nr.12,!Bl.113,!Sc.1,!Et.7,!Ap.19,!Sector!4,!
040129!Bucuresti!
Romania!
Tel:!+40:21:3173580!
!
!
Promax'International'
2A!Scout!Deguia!corner!Mother!Ignacia!Streets!
Laging!Handa!
1103.Quezon!City!
Metro!Manila!
Philippines!
Tel:!+63!2!4114100!
!
!
PROVENTUS'FARMS'PLUSS'Ltd'
22!Braslas!Str.!
Riga,!LV:1035!
Latvia!
Tel:!+37!126!165!971!
www.proventus.lv!
!
440!
!
!
!!
!
!
Provet'AG'
Gewerbestr!1!
CH:3421!!
Lyssach!
Switzerland!
Tel:!+41!(0)344481129!
www.provet.ch!
!
!
Pulte'GmbH'&'Co.'KG'
Postfach!1313!
83203!Prien/Chiemsee!
Germany!
Tel:!+49!8051!4587!
www.pulte.de!
!
!
PZ'Naše'Selo'
Borisa!Kidrica!59/o!
HR:!31324!Jagodnjak!
Croatia!
!
441!
!
!
!!
!
!
Radin'Feedar'Farda'
unit!3:!#3:!2nd!Alley!
Bucharest!(Ahmad!Ghasir)!St.:!Beheshti!St.!
IR:Tehran!
Iran!
Tel:!+98!21!88!52!58!11!
Fax:!+98!21!88!52!75!43!!!
!
!
Rostal'Resources'Ltd'
PM!News!House!
27,!Acme!Road!
Agidingbi!
Ikeja:Lagos!
Nigeria!
Tel:!+234!1!470!4440!
!
!
Ruth'Consolidated'Industries'Pty'Ltd'
7!to!9!Kent!Road!
Mascot!NSW!2020!
Australia!
Tel:!+61!296670700!
!
442!
!
!
!!
!
!
Safeed'
Volokolamskoe!shosse,!bild.!2!
Волоколамское!шоссе.,!д.!2!
Москва,!125993!
Russia!
Tel:!+7!495!640!39!96!
Email:[email protected];[email protected]!
www.safeed.ru!
!
!
Setna'
C/!Clavo,!1!:!Pol.!Ind.!Santa!Ana!
28522!:!RIVAS!VACIAMADRID!(Madrid)!
Spain!
Tel:!+34!91!666!85!00!
www.setna.com!
!
!
Shahroor'Trading'Co.'
Dabab!Street,!Somatco!Building!1st!floor!
P.O.Box!61439,!Opposit!to!Saudi!Holandi!bank!
!
443!
!
!
!!
SA!11565!Riyadh!
Saudi!Arabia!
Tel:!+966!1!40!444!03!
Fax:!+966!1!40!30!491!
!
!
Techniblend'
2!Duiker!Road!
Melkbosstrand!
7450!Cape!Town!
Western!Cape!
South!Africa!
Tel:!+27218844401!or!+27!828297407!!
www.techniblend.co.za!
!
!
Tecnavic'
Rua!Cleía,!515!–!Barrroso!
Fortaleza!–!CE!
60.863:280!
Brazil!
Tel:!+55!(!85)!3276:1011!
www.tecnavic.com.br!
!
444!
!
!
!!
!
!
UAB'Zalioji'Banga'
Vieversių!382!
sb!Gaižėnėliai,!Jauno!raj.!
Lithuania!
!
!
United'Company'for'Medical'Trade'LTD.'
Main!(Jenin)!Street,!Building!12!
P.O.BX!Tubas!/!500!
Facing!the!Red!Crescent!
Tubas,!West!Bank!
Palestine!
Tel:!+97!0!9!25!73!121!
Fax:!+97!0!9!25!73!121!
!
!
Varluaid'Co'Ltd'
32/2!Soi!Charoenrat!
18!Charoenrat!Road!
Khlongtonsai!
Khlongsan,!Bangkok!10600!
!
445!
!
!
!!
Thailand!
Tel:!+66!2!4375002!
!
!
Vetalmex'
Campo!Grande,!30!4°!A/B!
1700!093!Lisboa!
Portugal!
Tel:!+351!217!815!625!
!
!
Veterquimica'Boliviana'S.R.L.'
Av.!Pirai!nr.!493!
Casilla!3984!
Santa!Cruz!
Bolivia!
Tel:!+591!33520261!
!
!
VETBTRADE'LTD'
158,!Kniaz!Bois!Str.!
!
6000!Stara!Zagora!:!Bulgaria!
!
!
446!
!
!
!!
Bulgaria!
Tel:!+35!/!942!/!636!858!
Fax:!+35!/!942!/!636!858!
www.my:vet:trade.com!
!
!
Vimar'Gıda'Tarım'Hayvancılık'A.Ş.'
İstanbul!Anadolu!Yakası!Organize!Sanayi!Bölgesi!Aydınlı!Mah.!2.!Sanayi!Cad.!No:16!Tuzla!
Istanbul!
Turkey!
Tel:!+90!/!216!/!593!11!50!!
Fax:!+90!/!216!/!593!11!55!
www.vimar.com.tr!
!
!
Winfarm'
Antonio!Pratas!
Rua!das!Begonias!1!
Herdade!da!Aroeira!
2820:534!Charneca!da!Caparica!
Portugal!
Tel:!+35191!331!7235!
www.winfarm.pt!
!
!
447!
!
!
!!
!
World'Agri'Business'Co.'Ltd.'
542/3168!Sinthorn!Village!Happyland!Rd.!
TH:10240!Bangkapi!Bangkok!
Thailand!
Tel:!+66!2!374!2465!
Fax:!+66!2!375!6159!
!
!
'
'
!
448!
!
!
!!
Distributors'Carrying'Life'Science'Enzymes'
!
A2Z'Bio's.r.o.'
Zlatnicka!228!
25073!Jenstejn!
Czech!Republic!
Tel:!+420!777!944!670!
www.pabslabs.com!
!
!
AmpliGene'India'Biotech'Pvt.'Ltd.'
India!
Tel:!+91:79:26560941!!
Tel:!+91:88:66347317!!
www.ampligeneindia.com!
!
!
Asia'Bioscience'Co.,'Ltd.!
1F,No.15,!Lane!162,!Jianmin!Rd!
Beitou!District,!Taipei!City!112!
Taiwan!!
Tel:!+886:2:2827:1197!
!
449!
!
!
!!
www.abscience.com.tw!
!
!
Beijing'Suntrap'Science'&'Technology'Co.,Ltd.'
Room!1222,12F,Huatian!Building!
NO.6!Bei!Xiaomachang,Lianhuachidong!Road!
Haidian!District,Beijing!
China!
Tel:!+86!10!51917556!
Fax:!+86!10!51917557!
en.suntrapbj.com!
!
!
BioClone'Corp.!
4F!Haeryong!B/D,!911:2!Sinjeong4:Dong!
Yangcheun:Gu,!Seoul,!158:857!
South!Korea!
Tel:!+82!2!2690!0058!
Fax:!+82!2!2690!0397!
!
!
BioBConnect'BV!
Begonialaan!3A,!6851!TE!
!
450!
!
!
!!
Huissen!
!The!Netherlands!
Tel:!+31!(0)26!326!4464,!+32!(0)2!503!0348!
Fax:!+31!(0)26!326!4451,!+32!(0)2!503!0327!
Email:!info@bio:connect.nl!
www.bio:connect.nl!
!
!
BIOBKASZTEL'Ltd.'
1118!Budapest!
Kelenhegyi!út!22.!
Hungary!
Tel:!+36:1:3810694!
Fax:!+36:1:3810695!
www.kasztel.com!
!
!
BioTeltec'
Am!Moosbach!6!
74535!Mainhardt!
Germany!
Tel:!+49:7903:91440!
www.bioteltec.com!
!
451!
!
!
!!
!
!
Bond'Biotech,'Inc.'
No!7,!Ln!1,!Yishu!S.!St.,!Longjing!Dist.!
Taichung!City,!434!
Taiwan!
Tel:!+886!4:2652:1202!
Fax:!+886!4:2652:3797!
www.bondbiotech.com.tw!
!
!
Chayon'Laboratories'Inc.'
Korea!
www.chayon.co.kr!
!
!
Cosmo'Bio'Co.,'Ltd.'!
Toyo!Ekimae!Bldg.!2:20,!Toyo!2:chome!!
Koto:ku,!Tokyo,!135:0016!
Japan!!
Tax:!+(81)3:5632:9610!!
Fax:!+(81)3:5632:9619!!
www.cosmobio.co.jp!!
!
452!
!
!
!!
!
!
D.B.A.'ITALIA'S.R.L.'
Via!Umbria!10!
20090!Segrate!(Milano)!
Italy!
Tel:!+39!02!26922300!
www.dbaitalia.it!
!
!
Dyne'Bio'Inc''
B:205,!Woolimlions!ValleyИ!!
146:8!Sangdaewon:dong,!Jungwon:Gu,!Seongnam:Si!!
Gyeonggi:Do,!462:807!!
Korea!
Tel:!+82:02:571:1305!!
Fax:!+82:03:748:8265!!
www.dynebio.co.kr!
!
!
Funakoshi'Co.,'Ltd!
9:7!Hongo!2:Chome,!Bunkyi:ku,!!
Tokyo!113:0033!
!
453!
!
!
!!
Japan!
Tel:!+81:3:5684:1620!
Fax:!+81:3:5684:1775!
www.funakoshi.co.jp!
!
!
Genaxxon'bioscience'GmbH''
Soeflinger!Str.!100!!
89077!Ulm!!
Germany!
Tel:!+49!731!3608!123!!
Fax:!+49!731!3608!962!!
www.genaxxon.com!
!
!
Gene'Technologies''
No:12!,!Kutty!Street!!
Nugambakkam!
Chennai!:!600!034!!
India!
Tel:!44:!43561150!!
Fax!:!44:43561171!!
!
454!
!
!
!!
www.genetechnologies.co.in!
!
!
GeneWorks'Pty'Ltd'
www.geneworks.com.au!
PO!Box!299!
Hindmarsh!SA!5007!
Australia!
Tel:!(08)!8234!2644!
Fax:!(08)!8234!2699!
!
!
Hong'Jing'Co.,'Ltd.!
Address:!5F,No.174,!Sec!1,!Chung:Shan!Rd!
Young:Ho!District,!New!Taipei!City!
Taiwan!!
Tel:!+886:2:3233:8585!
www.hongjing.com.tw!
!
!
InterLabService'Ltd.'
3rd!Proezd!Perova!Polya,!8!building!1!
111123,!Moscow!
!
455!
!
!
!!
Russia!
Tel:!+7!(495)!664!2884!
Fax:!+7!(495)!664!2889!
www.interlabservice.ru!
!
!
M/s.'Bio'Rein'Technologies'Private'Limited!
#2!Third!Street,!Sri!Sakthi!Vijayalakshmi!Nagar!
Velachery!
Chennai:!600!042,!Tamil!Nadu!
India!
Tel:!+(98)!41730824!
www.bioreintechs.com!
!
!
MoreBio'Co.'Ltd.!
Woolim!Lions!Valley,!5ch!A:1505ho,!144:3!
Sangdaewon:dong,!Jungwon:gu!
Seongnam:si,!Gyeonggi:do,!462:120!
South!Korea!
Tel:!+82!2406!2942!
Fax:!+82!2406!2944!
!
456!
!
!
!!
www.morebio.co.kr!
!
!
Neobio'Comercio'de'Produtos'para'Laboratórios,'LTDA''
Rua!Cruz!Pereira,!384!!
CEP!18609:080!!
Botucatu,!SP!!
Brazil!!
Tel:!+55:14:3882:3343!!
!
!
NEW'TEST'Co(NTCo)'For'Scientific'&'Research'Services!
Mustafa!Kamel!
Alexandria,!!
Egypt!
Tel:!+20!3!5444736!
!
!
Noor'ALBSabah'Company'For'Medical,'Laboratory'Instruments'&'Supplies'(NSC)''
P.O.Box:!140757!Albayader!11814!!
Al:Shemisani,!Shaker!Bin!Zeid!Street!!
Building!#28!!
Amman!!
!
457!
!
!
!!
Jordan!!
Tel:!+962!6!5662366!Ext.!1!!
Fax:!+962!6!5662355!!
www.nooralsabahco.com!
(Distributes!in!multiple!countries!in!the!Middle!East)!
!
!
Novazym'Polska's.c.'
www.novazym.com!
ul.!Strzeszyńska!34!budynek!C!
60:479!Poznań!
Poland!
Tel:!+48!61!610!!39!10!
Fax:!+48!61!610!!39!11!
!
!
OOO'AlmaBBion'
Ul.!Vladimira!Nevskogo!59:166!
Voronezh!394005!
Russia!
Tel/fax:!+7(8)473!273:48:28!
Tel:!+7(8)473!273:77:52!
!
458!
!
!
!!
www.almabion.ru!
!
!
Pishgam'Biotech'Company''
Unit!7,!3rd!Floor,!Rose!Building,!!
1669!North!Kargar!St.!
Tehran!1413613148!
Iran!!
Tel:!+98!:!21!:!8801!4393!and!8800!3489!!
Fax:!+98!:!21!:!8801!4418!!
Emails:[email protected],[email protected]!!
www.pishgambc.com!
!
!
Porto'Med!
1!El!Safa!Street,!In!front!of!Wadi!El!Nile!hospital!
El!Kobba!El!Gedeedah!
Cairo!
Egypt!
Tel:!+20!01015553070!
Email:!info@porto:med.com!
www.Porto:Med.com!
!
!
Proquinorte'S.A.''
!
459!
!
!
!!
Alameda!de!Urquijo!87!!
48013!Bilbao!!
Spain!
Tel:!+34!902!999!211!!
Fax:!+34!94!441!68!73!!
www.proquinorte.com!
!
!
Quantum'Biotechnology!
No.90,!Ln.!319,!Dadun!6th!St.,!Nantun!Dist.!
Taichung!City!40864!
Taiwan!(R.O.C.)!
Tel:!+886:4:23863198!
Fax:!+(81)3:5632:9619!
!
!
Quatro'Tecnologìas'Moleculares'para'AND''
Pestalozzi!1204:903!!
Col.!Del!Valle!!
Mexico!!
Tel:!+525559371633!
!
!
ROC'TIBBI'TEKNOLOJI'SAN've'DIS'TIC'LTD!
!
460!
!
!
!!
Bakirko,!Istanbul,!34010!
Turkey!
Tel:!+(90)!2122100320!
www.roc.com.tr!
!
!
Sellex'(S.A.C)'
Rua!Arandu.!205!/!1105!
04562:030!
Sao!Paulo,!SP!
Brazil!
Tel:!(11)5506:4646!!
www.sellex.com!
!
!
ServLab'Co.''
#411!Sehwa!Officetel!!
79:4!Garak:dong!Songpa:gu!Seoul!
Korea!
Tel:!+82:2:449:8787!!
Fax:!+82:2:449:8786!!
www.servlab.co.kr!!
!
461!
!
!
!!
!
!
Shanghai'Boda'Biotech'Co.'Ltd'
Room!1010,!A!Building!No.!411,!Ruijin!er!Road,!Huangpu!District,!200025!
Shanghai!
China!
Tel:!021:64399151,!or!021:64399156!
!
!!
SISRO'MEDICARE!
NO.27,!4S!Square!
Thanthai!Periyar!Nagar!
G.V.Residency!Phase!II!
Sowripalayam!
Coimbatore!:!641!028!
Tamilnadu!
India!
Tel:!+91!422!4206831,!
Tel:!+91!9442200732,!8220001731!
www.sisromedicare.com!
!
!
Synergy'Scientific'Services''
!
462!
!
!
!!
B:2,G:1!Mahalakshmi!Apts!!
City!Link!Road,Adampakkam!!
Chennai:600!088!!
India!
Tel:!044!2245!2787!!
Tel:!9841522118!!
!
!
Team'Medical'&'Scientific'Sdn'Bhd'
404060!Shah!Alam!
Malaysia!
Tel:!603:5122!5108!
Fax:!603:5122!1608!
Email:!info@tms:lab.com!
www.tms:lab.com!
!
!
Trugene'Diagnostics,'Inc.''
8F!74!Song:Te!Rd.!!
Taipei!110!
Taiwan!
Tel:!+886!2!2758:2606!!
Fax:!+886!2!2729:9006!!
!
463!
!
!
!!
!
!
Valter'Occhiena'S.r.l.'
Via!Rosta,!7/bis!
10143!Torino!
Italy!
Tel:!+39!(0)11!7716971!
Fax:!+39!(0)11!7761800!
!
!
Vandateb!
Address:!3rd!Floor,!No.!1!
Zagros!Street,!Arjantin!Square!
Tehran!1514934147!
Iran!
Tel:!+982188672685:7!
Fax:!+982188672689!
www.vandateb.com!
!
!
VIRABGENE'Co.''
No!69!Pardis!St.,!North!Shiraz!St.,!Mollasadra!St.!
1991843985!Tehran!
Iran!!
!
464!
!
!
!!
Tel:!+98!21!88611552!!
Email:!Mahdi@vira:gene.com!!
www.bioshop.ir!!
!
!
VWR'International,'LLC''
www.vwr.com!
Radnor!Corporate!Center!!
Building!1,!Suite!200!!
100!Matsonford!Road!!
Radnor,!PA!19087!
USA!
Tel:!+1:800:932:5000!
!
!
WonWon'&'OneStar'Biotechnology'Co.,'Ltd.''
4F,!No.!84,!Gongjhuan!Rd.!!
Taishan!Township!
Taipei!County!24301!!
Taiwan!R.O.C.!!
Tel:!+886:2:2908:9742!!
Fax:!+886:2:2908:9444!!
!
!
!
465!

Enzyme Company Guide 2014 - Bio

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