here - 27th Annual Meeting of the Society for Virology

Transcription

PROGRAMME
26th Annual Meeting of
the Society for Virology
Gesellschaft für Virologie e. V. (GfV) und
DVV
Deutsche Vereinigung zur
Bekämpfung der Viruskrankheiten e. V. (DVV)
Viruses in Motion
© Presseamt Münster • Angelika Klauser
6–9 April 2016
Münster • Germany
University of Münster
www.virology-meeting.de
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Table of Contents
Welcome Notes
Conference Chair........................................................................................................ 4
President of the Society for Virology (GfV)................................................................. 5
President of the Robert-Koch-Institute (RKI).............................................................. 6
President of the Friedrich-Loeffler-Institute (FLI)........................................................ 8
Organisation and Imprint............................................................................................................ 10
Societies and Meetings.............................................................................................................. 11
Virology at the WWU Münster.................................................................................................... 12
Cluster of Excellence “Cells in Motion” (CiM)............................................................................. 13
Münster Graduate School of Evolution (MGSE)........................................................................ 14
Keynote Speakers, Awards, Poster Prize Committee and Chair Persons................................. 15
Programme Overviews............................................................................................................... 16
Scientific Programme
Wednesday, 6 April 2016............................................................................................. 20
Thursday, 7 April 2016................................................................................................. 28
Friday, 8 April 2016...................................................................................................... 36
Saturday, 9 April 2016................................................................................................. 46
Poster Sessions
Poster Session 1......................................................................................................... 51
Poster Session 2......................................................................................................... 66
Poster Session 3......................................................................................................... 83
Sponsors.................................................................................................................................... 102
Media Cooperations and Scientific Sponsors............................................................................ 103
Industrial Exhibition.................................................................................................................... 104
Exhibitors (in alphabetical order)................................................................................................ 105
Floor Plan................................................................................................................................... 106
Site Map..................................................................................................................................... 107
General Information................................................................................................................... 108
Social Programme...................................................................................................................... 114
Index of Presenting Authors and Chair Persons........................................................................ 116
Upcoming Conferences and Meetings....................................................................................... 134
p3
Welcome Note • Conference Chair
Dear colleagues,
It is a great pleasure to invite you to the 26th Annual Meeting of the Society for Virology held from
6–9 April 2016 in Münster, Germany.
The meeting will be hosted by the Westphalian-Wilhelms-University and will take place in the main
lecture hall building at the Schlossplatz, directly opposite of the Münster castle and in close proximity to the historical city center of Münster.
The University of Münster is one of the four largest universities in Germany with 43,000 students
to date. The high number of students, university teachers and scientists that dominate the city not
only creates a stimulating atmosphere of creativity and scientific curiosity, it also guarantees for the
existence of a wide variety of pubs, bistros and restaurants that are waiting for you for vivid and
stimulating after-meeting discussions.
The scientific programme will stand under the main theme “Viruses in Motion”. This theme will be
reflected in plenary sessions such as “Visualising Viruses” that will be organised together with the
Münster Cluster of Excellence “Cells in Motion” and will focus on high-resolution imaging of the
dynamics of virus replication. Another plenary session “Evolution of Viruses – Viruses in Evolution”
organised together with the Münster Graduate School of Evolution will focus on the evolutionary
motion of viral pathogens including their role in evolution of higher organisms. Other sessions will
highlight emerging pathogens as well as the interaction of viruses with the host and immune system. Of course, every other topic in virology will also be covered in workshops and poster sessions.
Since a major aim of the meeting is to provide a platform for young scientists to present their results
and ideas, we particularly welcome next generation´s researchers joining us and would like to encourage all senior virologists to promote their mentees´ attendance.
Many years ago, the city of Münster hosted a milestone event in history, when, after five years of
meetings and negotiations, the Westphalian peace treaty was signed in 1648, which finally ended
the Thirty Years’ War. Thus, Münster can claim a long-standing history to organise successful conferences. In that sense I am convinced that we will also have a very successful and stimulating 26th
Annual Meeting of the Society for Virology in our beautiful city.
The organising committee and I are looking forward to welcome you all here in Münster!
Prof. Dr. Stephan Ludwig
Conference Chair
p4
Welcome Note • President of the Society for Virology (GfV)
Dear colleagues,
I warmly welcome you to our annual scientific meeting of the Society for Virology (GfV). As you
may remember, during the last conference in Bochum we celebrated the 25th birthday of our society,
which has become highly established among the scientific societies in Germany and is by now the
greatest virological society in Europe with currently 1,300 members. Thus, our GfV is more than
vivid.
The society covers the field of virology from basic research to medical virology, a field of great
scientific, epidemiological, medical and social impact. By nature, virology is also a cross-sectional
discipline and can therefore contribute fruitfully to many interdisciplinary research initiatives.
Still, the most obvious evidence of the vitality of our Society is our annual meeting and again, this
year we have an exciting program of high quality. Many researchers will present their contributions,
from young graduate students to internationally renowned scientists.
I am convinced that we will have a very successful, challenging and scientifically stimulating meeting. At this point, I also want to welcome our international guests and deeply feel the need to give
my special thanks to Prof. Stephan Ludwig, all the organizers and the many helpers for the work
and responsibilities they have taken on to prepare and to perform this year’s highlight in virology.
Prof. Dr. Thomas Mertens
President of the GfV
p5
Welcome Note • President of the Robert-Koch-Institute (RKI)
Dear colleagues, Infectious Diseases caused by viruses are as fascinating and challenging as ever. Be it the unexpected
current Zika virus epidemic in the Americas or the expected yearly Influenza epidemic – prediction and
timely risk assessment and communication remain challenging and thus will stay an exciting area of
research. Threats to global health through emerging diseases foster long term cooperation and good
networking with partners from hot spots of emerging infectious diseases, be it in Germany or on a global
scale. Thus, interdisciplinary collaborations are key for understanding factors for the emergence of diseases, ranging from molecular biology, immunology to anthropology and ecology – an approach known
as the “One Health” concept. We are therefore excited to watch the outcome of the recent grant funding
line “Zoonoses research”, jointly launched by the German ministries for Research and Education, Health,
Food and Agriculture as well as Defense. As Public Health Institute the Robert Koch Institute takes its
responsibility by sound epidemiological risk assessment, hypothesis driven wet lab research and evidencebased prepardness. As a result, over the years, the Society for Virology and the Robert Koch Institute
have developed strong and close ties, being authoritative partners, both in research and counselling, and
more than 40 present and former virologists of the Robert Koch Institute are members of the Society for
Virology. Since the Annual Meeting of the Society for Virology is an excellent platform to present latest
findings of various aspects in virological research special attention will be given to young scientists to
present their results and ideas. Actually, a number of young scientists from the Robert Koch Institute will
attend this outstanding conference presenting their data and taking part in discussions. Some of them
as rookies are highly excited and ready to unleash their talents. As I have learned from the organizing
committee the main theme of this year´s 26th Annual Meeting of the Society for Virology will be “Viruses
in Motion” including dynamics of viral replication, virus evolution, emerging pathogens and virus-host
interaction. These topics are of special interest for the virologists at the Robert Koch Institute since they
are mainly engaged in pathogen-specific characteristics including changes and genetic heterogeneity,
influencing spread and virulence of the pathogens and their ability to gain control over the host immune
system. It is this research innovation that will provide physicians, epidemiologists, the vaccine sector and
the general public not only with information on the circulation of i.e. respiratory viruses and the properties of epidemic strains, but also to help with an assessment of the pathobiology of novel virus strains.
Results of this work will hopefully enable the derivation of novel principles for the control of these notorious pathogens. Needless to say that science will only flourish by trustful cooperation - the Robert Koch
Institute has been and will stay a trustworty partner. Let me finally thank the organizing committee of the
26th Annual Meeting of the Society for Virology for their great commitment in organizing and running this
conference. I wish all attendees best success, interesting talks and discussions, and taking back home
a number of fruitful new ideas.
Prof. Dr. Lothar H. Wieler
President of the RKI
p6
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Welcome Note • President of the Friedrich-Loeffler-Institute (FLI)
Dear Colleagues,
Viruses are the most abundant life form on earth. ‘Life’? No virologist would doubt this! Viruses
emerge, multiply, evolve, recombine, reassort. Viruses are indeed ‘in motion’! They can devastate
their hosts or live innocuously in perfect adaptation. They provide continuous surprises with the
detection of new virus species, families, even orders; with unexpected changes in virus virulence
or epidemiology; and with the knowledge that we are aware of only a tiny fraction of the viruses
on this planet, primarily those which affect us directly or indirectly. Thus, virology is and remains a
vast field for research from basic understanding of molecular details of virus-host interaction to the
development of antiviral strategies including therapeutic and prophylactic interventions.
Virus research has been the core competence of the Friedrich-Loeffler-Institut since it has been
founded by the co-discoverer of foot-and-mouth disease virus and co-founder of the scientific discipline of virology, Friedrich Loeffler, on October 10, 1910. Although its portfolio has expanded
significantly since then, eight of eleven departments of the FLI focus on infectious diseases with a
special emphasis on virology. With its history in research on infections of food-producing animals,
the institute is well placed to participate in interdisciplinary interactions, in particular concerning
the ‘One Health’ concept which is centered on the cooperation between human and veterinary
medicine but extends to include biological, environmental and social sciences. Earlier this year the
German ministries for Education and Research; Health; Food and Agriculture; and Defense joined
in a new agreement on funding a national research network for zoonotic infectious diseases. This
allows the continuation of the successful German Research Platform for Zoonoses coordinating
research on pathogens shuttling between animals and humans. The FLI is pleased to be able to
contribute by supporting and hosting the ‘veterinary office’ of this network. As a new member of the
German Center for Infection Research (DZIF) the FLI will also increase participation in respective
cooperative research activities within this consortium.
Avian flu, SARS, Swine Flu, MERS, Ebolavirus Disease, Zikavirus infection…infectious diseases
caused by viruses frequently hit the headlines all over the world. They symbolize that globalization
not only concerns global travel and commerce but also global health. This concept has been adopted last year at the G7 summit returning infectious diseases to the top level of priorities, a position
they seem to have lost in the 1970’s and 80’s after the spectacular successes of the 1950’s and
60’s. The book on infectious diseases is definitely not closed!
However, we should not forget that viruses are more than nanoparticular elements with the capacity
to do harm. They are essential components of the ecosystem, drivers of evolution, tools to analyze
and understand basic biological principles. In this context I very much welcome the inclusion of
plant viruses in this program and look forward to hearing about novel developments in these somewhat less ‘visible’ but highly exciting areas of virus research.
p8
Welcome Note • President of the Friedrich-Loeffler-Institute (FLI)
The annual meeting of the Society for Virology is a ‘must’ for virologists in our region covering a
wide range of topics from basic science to application but always focusing on the scientific aspects
of the different approaches. It is also a ‘family reunion’ to meet fellow virologists for discussion and
future planning. ‘Networking’ is the catchword of the day. And there are many nets to be woven in
our common interest to understand these ‘most tiny living beings’ (quoted from Friedrich Loeffler).
The organization of such a conference is a major challenge and experience, and I want to particularly thank the local organizers for their willingness to accept this burden for the benefit of all
virologists. I am certain we will enjoy an interesting and pleasant conference.
Prof. Dr. Dr. h.c. Thomas C. Mettenleiter
President of the FLI
p9
Organisation and Imprint
Venue
University of Münster (WWU) Central Auditorium Building – Schlossplatz 2 • lectures
Vom-Stein-Haus – Schlossplatz 34 • posters/industrial exhibition/catering/registration
48149 Münster (DE)
Organiser
Gesellschaft für Virologie e. V. (GfV, Society for Virology)
www.g-f-v.org
Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.
(DVV, German Association for the Control of Virus Diseases)
www.dvv-ev.de
Conference Chair
Prof. Dr. Stephan Ludwig
Institute of Molecular Virology • Center for Molecular Biology of Inflammation (ZMBE)
University of Münster (WWU)
48149 Münster (DE)
Local Organising Committee
Dr. Friederike Jansen (Münster/DE)
Sebastian Sprengel (Münster/DE)
Conference Organisation
Conventus Congressmanagement & Marketing GmbH
Marlen Schiller
Carl-Pulfrich-Straße 1 • 07745 Jena (DE)
Tel. +49 3641 31 16-358 • Fax +49 3641 31 16-243
[email protected] • www.conventus.de
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23 March 2016
Societies and Meetings
Executive Committee of the Society for Virology (GfV, Gesellschaft für Virologie)
President Thomas Mertens (Ulm/DE)
Secretary Sigrun Smola (Homburg a. d. S./DE)
Treasurer Detlev H. Krüger (Berlin/DE)
Vice Presidents Hartmut Hengel (Freiburg/DE)
Franz X. Heinz (Vienna/AT)
Former Presidents Nikolaus Müller-Lantzsch (Homburg a. d. S./DE)
Hans-Dieter Klenk (Marburg/DE)
Otto Haller (Freiburg/DE)
Bernhard Fleckenstein (Erlangen/DE)
Advisory Board Ralph Bartenschlager (Heidelberg/DE)
Stephan Becker (Marburg/DE)
Ulf Dittmer (Essen/DE)
Helmut Fickenscher (Kiel/DE)
Frank Kirchhoff (Ulm/DE)
Klaus Osterrieder (Berlin/DE)
Thomas Pietschmann (Hanover/DE)
Sibylle Schneider-Schaulies (Würzburg/DE)
Thomas Schulz (Hanover/DE)
Beate Sodeik (Hanover/DE)
For more information and for membership application, please visit our website www.g-f-v.org.
German Association for the Control of Virus Diseases
(DVV, Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.)
President Barbara Gärtner (Homburg/DE)
Meetings of the Society for Virology
GfV Board Meeting Wednesday, 6 April 2016, 19.30–21.45
(Vorstands- und Beiratssitzung) Festsaal (ballroom), Schlossplatz 5
GfV General Assembly (Mitgliederversammlung) Thursday, 7 April 2016, 18.45–19.45
Lecture Hall 1
p 11
Virology at the WWU Münster
imv
Up to 2005 the discipline of virology in teaching, research and patient care at the medical faculty
of the University of Münster was organized in a subdivision of the Institute of Medical Microbiology
and didn´t exist as an own institutional entity. This changed with the establishment of the Institute
of Molecular Virology (IMV) in 2005. The IMV is one of five institutes at the Centre of Molecular
Biology of Inflammation (ZMBE) in Münster, a unique research center in Germany that addresses
the complex processes of inflammation from various angles.
Research at the Institute of Molecular Virology (headed by Prof. Dr. Stephan Ludwig) focuses on
intracellular signal transduction pathways and their impact on viral infection and inflammation. The
virology research is mainly focussed on influenza viruses, which still represent a serious health
problem in humans and animals worldwide. One aim of the work is – via gathering knowledge
about the cellular processes that control virus replication – to learn more about viral reproduction
strategies and to eventually find new approaches for antiviral intervention by targeting cellular components. The institute just recently reached an important milestone in that approach by contributing
to the successful completion of the first phase 2b clinical trial with a cell-directed signalling inhibitor
against severe influenza in collaboration with scientists from Giessen and Tübingen, driven forward
by a partner company.
One of the missions at the ZMBE is to support young researchers on their way to establish their
independent scientific profile. One subgroup at the IMV, headed by PD Dr. Christina Ehrhardt, focuses on bacterial co-infection in severe influenza. The IMV-associated Emmy Noether Research
Group of Dr. Mario Schelhaas, who received the Loeffler Frosch Award of the GfV in 2013 and just
recently was awarded a prestigious ERC consolidator grant, is interested in cell biology of virus
infections centered around virus entry processes. The most recent addition to the institute is Dr.
Eike Hrincius who started to establish his own junior research group in January 2016.
Regarding national networking the IMV also hosts the coordination office of the FluresearchNet,
a first nationwide interdisciplinary research network on zoonotic influenza and one of the three
decentralized offices of the German Research Platform of Zoonoses. As part of these activities
the IMV (co)-organizes the biannual International Influenza Meeting in Münster (next meeting Sep
25–27, 2016) and the yearly National Symposium on Zoonosis Research in Berlin (next symposium
Oct, 13–14, 2016) to both of which you are cordially invited.
As a future outlook, the IMV will also take over responsibility of clinical virology, welcoming Prof.
Dr. Joachim Kühn and his group as new members of the institute starting in Sept 2016. The IMV
will further join forces with the Institute of Medical Microbiology and the Institute of Hygiene when
moving to a new building, the Center of Infection Medicine expected in 2019.
p 12
Cluster of Excellence „Cells in Motion“ (CiM)
Imaging to Understand Cellular Behaviour in Organisms
Our body is made up of approximately one hundred trillion cells that are the elementary building
blocks of all tissues and organs required for life. “Cells in motion” keep body functions in a balance
and determine whether we are healthy or not, which is why the researchers of the Cells-in-Motion
Cluster of Excellence (CiM) study these cellular processes. Around 80 research groups of the University of Münster and the Max Planck Institute of Molecular Biomedicine aim to decipher crucial
aspects of cellular behaviour in organisms by analysing systems of increasing complexity – from
individual cells, to cells in barriers, to cells in complex systems.
To understand the dynamic interactions of cells in organisms, it is essential to see the cells of
interest. The use and development of novel imaging strategies is therefore central to CiM’s concept. Biomedical imaging links different scientific disciplines in CiM – from medicine and biology, to
chemistry and pharmacy, to physics, mathematics and computer science. The connection between
biomedical research and imaging guarantees continual progress both in basic research and in the
translation of information on cell behaviour to clinical applications.
Researchers in CiM also explore the motion and spread of pathogens in cells and organisms with
the aim to visualize molecular steps in pathogen replication in cells and organisms. This includes
studies on different viruses performed by CiM members at the Institute of Molecular Virology and
the associated research unit Cell Biology of Virus Infections.
CiM has been funded since 2012 by the German Research Foundation (DFG) in the context of the
Excellence Initiative of the German federation and the federal states.
Visualization of influenza A virus ribonucleoprotein (RNP) complexes by super resolution light microscopy. Influenza
virus RNPs (green) in close proximity to mitochondria (red) have been visualized by stochastic optical reconstruction
microscopy (STORM). The original STORM picture is shown left, a modelled reconstruction of RNP at right (Liedmann et
al. (2014) Nat Commun. 5:5645).
p 13
Münster Graduate School of Evolution (MGSE)
Evolution is broadly defined as a gradual development that may lead to a more advanced or complex form. Modern evolutionary thinking can help to understand and address urgent problems of
humankind, such as climate change, bioinvasions, or (infectious) disease epidemiology.
The MGSE is an interdisciplinary graduate school that is devoted to the interdisciplinary study of
evolution on multiple scales and levels. Researchers from the faculties of Biology, Medicine, Philosophy, Geosciences, and Mathematics contribute to the MGSE, thus forming an interdisciplinary
network of excellent scientists working on diverse topics in evolution. The main research areas
of the MGSE include earth system evolution, the history of life, the evolutionary ecology of rapid
adaptations, molecular and genome evolution, evolution of pathogens, and the philosophy of evolutionary sciences. One of the major academic aims of MGSE is to connect natural and life sciences
with the humanities in a mutually beneficial way.
The MGSE offers a structured, multidisciplinary doctoral programme that is tailored to individual
career tracks. While the work in each doctoral project is performed at the highest possible scientific level within its discipline, interdisciplinarity is achieved through a specific mentoring system.
MGSE doctoral students benefit from one another because similar general principles act across
disciplines, thus allowing for common theoretical approaches and experimental testing at different
levels.
A unique structural component of the MGSE is the Evolution Think Tank (ETT) that is instrumental
in achieving the graduate school’s academic aims. It consists of a Junior Research Group Leader
and internationally outstanding scientists from different disciplines (ETT-Fellows) who visit the
MGSE for 1–6 months. In close cooperation with the doctoral students, the ETT seeks to develop
new ideas end establish mechanisms for the transfer and application of evolutionary knowledge.
Graduating within the interdisciplinary framework of the MGSE at the WWU Münster provides doctoral students with the necessary skills for acquiring and applying knowledge in a multi-disciplinary
world.
p 14
Keynote Speakers, Awards, Poster Prize Committee and Chair Persons
Keynote Speakers
R. Andino (San Francisco, CA/US)
R. Belshaw (Plymouth, Devon/GB)
H. Feldmann (Hamilton, MT/US)
Y. Kawaoka (Madison, WI/US)
H.-G. Kräusslich (Heidelberg/DE)
C. Münz (Zurich/CH)
M. Schwemmle (Freiburg/DE)
N. F. Steinmetz (Cleveland, OH/US)
B. Sun (Shanghai/CN)
B. tenOever (New York, NY/US)
M. Way (London/GB)
Z. Yuan (Shanghai/CN)
Awards
Loeffler-Frosch-Award
A. Bergthaler (Vienna/AT)
Loeffler-Frosch-Medal
A. Helenius (Zurich/CH)
Poster Prize Committee
I. Drexler (Düsseldorf/DE)
J. Kühn (Münster/DE)
S. Pleschka (Giessen/DE)
Chair Persons
S. Becker (Marburg/DE)
M. Beer (Greifswald, Isle of Riems/DE)
B. Biesinger (Erlangen/DE)
S. Boulant (Heidelberg/DE)
M. Brinkmann (Braunschweig/DE)
M. Budt (Berlin/DE)
L. Cicin-Sain (Braunschweig/DE)
S. Ciesek (Essen/DE)
C. Claus (Leipzig/DE)
U. Dittmer (Essen/DE)
I. Drexler (Düsseldorf/DE)
J. F. Drexler (Bonn/DE)
A. Ehrhardt (Witten/DE)
C. Ehrhardt (Münster/DE)
O. Fackler (Heidelberg/DE)
G. Gabriel (Hamburg/DE)
B. Gärtner (Homburg/Saar/DE)
K. Gibbert (Essen/DE)
T. Gramberg (Erlangen/DE)
A. Grundhoff (Hamburg/DE)
T. Grunwald (Leipzig/DE)
R. Kaiser (Cologne/DE)
A. Karlas (Berlin/DE)
A. Kieser (Munich/DE)
B. Klempa (Berlin/DE)
B. Klupp (Greifswald, Isle of Riems/DE)
G. Kochs (Freiburg/DE)
R. König (Langen/DE)
F. Kreppel (Ulm/DE)
C. Leib-Mösch (Neuherberg/DE)
D. Lindemann (Dresden/DE)
P.-Y. Lozach (Heidelberg/DE)
D. B. Müller (Heidelberg/DE)
M. Müller (Heidelberg/DE)
M. A. Müller (Bonn/DE)
M. Pawlita (Heidelberg/DE)
A. Pichlmair (Martinsried/DE)
T. Pietschmann (Hanover/DE)
O. Planz (Tübingen/DE)
S. Pöhlmann (Göttingen/DE)
D. Sauter (Ulm/DE)
T. Schaller (Heidelberg/DE)
M. Schelhaas (Münster/DE)
J. Schmidt-Chanasit (Hamburg/DE)
B. Sodeik (Hanover/DE)
P. Stäheli (Freiburg/DE)
E. Steinmann (Hanover/DE)
M. Tenbusch (Bochum/DE)
M. Trilling (Essen/DE)
C. Uetrecht (Hamburg/DE)
T. W. Vahlenkamp (Leipzig/DE)
J. Verheyen (Essen/DE)
F. Weber (Giessen/DE)
B. Weißbrich (Würzburg/DE)
p 15
Programme Overview • Wednesday, 6 April 2016
Track I – The Virus
Track II – The Host
Track III – The Clinical View
11.30–12.15
Opening Industrial Exhibition by the Conference Chair and Round Tour
12.15–13.00
Opening Ceremony
Lecture Hall 1
p. 20
13.00–14.30
Plenary Lecture 1
Visualizing Viruses
Lecture Hall 1
p. 20
14.30–15.30
Coffee Break within the Industrial Exhibition
Workshop 1
Virus Receptors and Entry
Lecture Hall 1
p. 21
Workshop 4
Viral Replication I
p 16
Workshop 2
Innate Immunity I
Vom-Stein-Haus
15.30–17.00
17.00–17.45
Lecture Hall 2
p. 21
Lecture Hall 1
p. 23
Workshop 5
Innate Immunity II
19.15–21.30
19.30–21.30
Workshop 3
Diagnostic Tools
Lecture Hall 3
p. 22
Vom-Stein-Haus
17.45–19.15
Get-Together within the Industrial Exhibition
Poster Session 1
Innate Immunity I & II
Diagnostic Tools
Viral Replication I & II
Vom-Stein-Haus
Lecture Hall 3
p. 24
Workshop 6
Virus Imaging
Lecture Hall 2
p. 25
p. 113
Vom-Stein-Haus (SR07, SR10, SR11)
p. 51
Programme Overview • Thursday, 7 April 2016
Workshop 7
Viral Replication 2
08.30–10.00
Workshop 8
Adaptive Immunity 1
Workshop 9
Emerging Viruses
Lecture Hall 3
p. 28
10.45–12.15
Plenary Lecture 2
Emerging Viruses
10.00–10.45
Lecture Hall 2
p. 29
Lecture Hall 1
p. 30
Vom-Stein-Haus
Lecture Hall 1
p. 31
Lunch Break within the Industrial Exhibition
12.30–13.30
Lunch Symposium
Hologic Deutschland GmbH
Lecture Hall 2
p. 31
14.00–15.30
Workshop 10
Trafficking
Workshop 11
Adaptive Immunity 2
Lecture Hall 2
p. 31
Poster Session 2
Adaptive Immunity I & II
Emerging Viruses
Trafficking
Virus Vectors and Gene Therapy
Structure and Assembly
17.30–18.45
Laudationes and Presentations
Loeffler Frosch Award and Medal
18.45–19.45
GfV General Assembly
15.30–17.30
Vom-Stein-Haus
Workshop 12
Lecture Hall 1
p. 32
15.30–17.30
Tumor Viruses
Antiviral Therapy and Resistance
Evolution of Viruses – Viruses in Evolution
Signal Transduction
Lecture Hall 3
p. 33
Vom-Stein-Haus
Vom-Stein-Haus (Halls, SR06)
p. 66
Lecture Hall 1
p. 34
p. 34
p 17
Programme Overview • Friday, 8 April 2016
Workshop 13
Workshop 14
Tumor viruses
Lecture Hall 1
p. 36
10:45–12:15
Plenary Lecture 3
Viral Interaction with the Host and the Immune
System
Lecture Hall 1
p. 39
08.30–10.00
10.00–10.45
Workshop 15
Antiviral Therapy and Resistence
Lecture Hall 2
p. 37
Lecture Hall 3
p. 38
Vom-Stein-Haus
12.30–13.30
Lunch Symposium
Qiagen GmbH
Lecture Hall 2
p. 39
Workshop 16
Evolution of Viruses – Viruses in
Evolution
13.45–15.15
Workshop 17
Signal Transduction
Lecture Hall 3
p. 40
Workshop 19
Viral Pathogenisis and Persistence
Lecture Hall 2
p. 43
Poster Session 3
Vaccines
Viral Pathogenesis and Persistence
Epidemiology and Public Health
Zoonoses
Social Evening
15.15–16.00
Workshop 18
Vaccines
Lecture Hall 1
p. 41
Workshop 20
Host Cell Factors and Modulation I
20.00–01.00
Lecture Hall 2
p. 42
Vom-Stein-Haus
16.00–17.30
17.30–19.30
Vom-Stein-Haus
Lecture Hall 1
p. 44
Workshop 21
Lecture Hall 3
p. 45
Vom-Stein-Haus (SR116, SR118)
p. 83
p. 113
p 18
Programme Overview • Saturday, 9 April 2016
Workshop 22
Zoonoses
08.30–10.00
Workshop 23
Host Cell Factors and Modulation II
Workshop 24
Clinical Virology
Lecture Hall 1
p. 46
10.45–12.15
Plenary Lecture 4
Evolution of Viruses – Viruses in Evolution
12.15–12.45
Poster Prizes and Farewell
10.00–10.45
Lecture Hall 2
p. 47
Lecture Hall 3
p. 48
Vom-Stein-Haus
Lecture Hall 1
p. 49
Lecture Hall 1
p. 49
Please note!
All lectures will take place in the Central Auditorium Building – Schlossplatz 2.
The poster sessions, industrial exhibition, catering as well as the registration is located in the
Vom-Stein-Haus – Schlossplatz 34.
Please refer to pages 108/109 for a detailed floor plan and follow the signposting on site.
p 19
Scientific Programme • Wednesday, 6 April 2016
11.30
Opening Industrial Exhibtion by the Conference Chair and Round Tour
12.15–13.00
Room
Opening Ceremony
Lecture Hall 1
Welcome Note by the President of the Society for Virology (GfV)
T. Mertens (Ulm/DE)
Welcome Note by the Conference Chair
S. Ludwig (Münster/DE)
Welcome Note by the Chinese Delegation
G. F. Gao (Beijing/CN)
Musical Interlude
Prof. Peter von Wienhardt and Chamber Ensemble
Hollywood Suite “SciFi”
Musical Interlude
Prof. Peter von Wienhardt and Chamber Ensemble
Hollywood Suite “Fanfare and the wild, wild west”
13.00–14.30
Plenary Lecture 1 – Visualising Viruses
(organised in cooperation with the Cluster of Excellence “Cells in Motion”)
Room
Lecture Hall 1
Chairs
M. Schelhaas (Münster/DE), T. Pietschmann (Hanover/DE)
13.00
Dynamics and structural changes upon HIV-1 maturation
13.30
Plant virus-based nanotechnologies enabling molecular imaging and therapies
N. F. Steinmetz (Cleveland, OH/US)
14.00
How vaccinia virus (ab)uses the host cytoskeleton to promote its spread
M. Way (London/GB)
14.30–15.30
RoomVom-Stein-Haus
p 20
15.30–17.00
Room
Chairs
15.30
V1
Workshop 1 – Virus Receptors and Entry
Lecture Hall 1
D. Lindemann (Dresden/DE), P.-Y. Lozach (Heidelberg/DE)
15.45
V2
16.00
V3
16.15
V4
Identification of mammalian cell lines that allow the propagation of recombinant
H18N11 bat influenza A virus
G. Zimmer, S. Locher (Mittelhäusern/CH), E. Moreira, M. Juozapaitis (Freiburg/DE)
T. Aydilllo, A. García-Sastre (New York, NY/US), M. Schwemmle (Freiburg/DE)
Molecular mechanism of Ebola virus entry into host cells
Ha. Wang, Y. Shi, J. Song, J. Qi, G. Lu, J. Yan, G. F. Gao (Beijing/CN)
Differential use of C-type lectins for phleboviruses endocytosis
P. Leger (Heidelberg/DE), M. Tetard (Heidelberg/DE; Paris/FR), B. Youness
N. Cordes (Heidelberg/DE), R. Rouxel (Jouy-en-Josas/FR), M. Flamand (Paris/FR)
P.-Y. Lozach (Heidelberg/DE)
Nanoscale approaches to characterise the dynamic and biophysical
determinants of receptor-mediated virus internalisation
M. Fratini, T. Wiegand, A. Cavalcanti-Adam, S. Boulant (Heidelberg/DE)
16.30
The importins of nuclear targeting of herpes simplex virus in fibroblasts and neurons
V5
K. Döhner, D. Bialy, F. Anderson, A. Buch, T. Koithan, A. Hinz, A. Binz
K. Rudolph (Hanover/DE), S. Hügel (Lübeck/DE), F. Rother (Berlin/DE)
E. Hartmann (Lübeck/DE), R. Bauerfeind (Hanover/DE), M. Bader (Berlin/DE)
16.45
The minor capsid protein of human papillomaviruses tethers the viral genome to
V6
mitotic chromosomes for nuclear entry
I. Aydin, M. Schelhaas (Münster/DE)
15.30–17.00
Workshop 2 – Innate Immunity I
Room
Lecture Hall 2
Chairs
A. Pichlmair (Martinsried/DE), K. Gibbert (Essen/DE)
15.30
DDX19A senses viral RNA and mediates NLRP3-dependent inflammasome
V7activation
J. Li, L. Hu, Y. Liua, L. Huang, X. Cai, C. Weng (Harbin/CN)
p 21
15.45
V8
cGAS-mediated innate immunity spreads through HIV-1 Env-induced
membrane fusion sites between infected and uninfected cells
A. Ducroux, S. Xu, A. Ponnurangam (Hanover/DE), T. Zillinger (Bonn/DE)
A. Malassa, E. Ewald (Hanover/DE), V. Hornung (Munich/DE)
W. Barchet (Bonn/DE), C. Goffinet (Hanover/DE)
16.00
V9
16.15
V10
16.30
V11
16.45
V12
15.30–17.00
Room
Chairs
15.30
V13
15.45
V14
Inhibition of type I interferon induction by sandfly fever Sicilian virus virulence
factor NSs
J. D. Wuerth (Marburg/DE), M. Habjan, A. Pichlmair (Martinsried/DE)
G. Superti-Furga (Vienna/AT), F. Weber (Marburg, Giessen/DE)
p 22
Evidence for a positive role of PML in interferon signaling that is antagonised by
the IE1 protein of human Cytomegalovirus
M. Scherer, V. Otto, R. Müller, N. Reuter, J. Stump, S. Klingl, Y. Muller, H. Sticht
T. Stamminger (Erlangen/DE)
Cellular polarity is a master regulator of the antiviral innate immune response in
intestinal epithelial cells
M. Stanifer, A. Rippert, C. Kischnick, S. Bender, R. Bartenschlager
S. Boulant (Heidelberg/DE)
Bat Mx proteins – Evolution and antiviral specificity
J. Fuchs, M. Schilling (Freiburg/DE), C. Patzina (Zurich/CH), M. Hölzer (Jena/DE)
M. Müller (Bonn/DE), T. Hoenen (Greifswald, Isle of Riems/DE; Hamilton, MT/US)
G. Zimmer (Mittelhäusern/CH), F. Weber (Marburg/DE), M. Marz (Jena/DE)
Workshop 3 – Diagnostic Tools
Lecture Hall 3
M. Pawlita (Heidelberg/DE), B. Weißbrich (Würzburg/DE)
Development of an antibody capture ELISA using inactivated Ebola Zaire
Makona virus
V. Krähling, D. Becker, C. Rohde, M. Eickmann, Y. Eroğlu, A. Herwig (Marburg/DE)
R. Kerber (Hamburg/DE), K. Kowalski, J. Vergara-Alert, Step. Becker (Marburg/DE)
Generation of a Gaussia luciferase-expressing endotheliotropic
cytomegalovirus for screening approaches and mutant analyses
J. J. Falk, K. Laib Sampaio, C. Stegmann, D. Lieber (Ulm/DE), B. Kropff
M. Mach (Erlangen/DE), C. Sinzger (Ulm/DE)
16.00
V15
A conserved epitope mapped with a monoclonal antibody against the VP3 protein
of Goose Parvovirus by using peptide screening and phage display approaches
C. Li, H. Liu, J. Li, D. Liu, R. Meng, Q. Zhang, W. Shaozhou, X. Bai, T. Zhang
M. Liu, Y. Zhang (Harbin/CN)
16.15
Monitoring and characterisation of swine influenza virus (swIAV) in Europe
V16
since 2015 – newly developed hemagglutinin- and neuraminidase-specific
multiplex RT-qPCR
D. Henritzi (Greifswald, Isle of Riems/DE), S. Wacheck (Dessau-Tornau/DE)
M. Beer, T. Harder (Greifswald, Isle of Riems/DE)
16.30
Screening for potential interaction partners of Bovine Herpesvirus-1
V17
glycoprotein E and implications for diagnostics
S. Koethe, P. König, G. M. Keil, M. Beer (Greifswald, Isle of Riems/DE)
16.45
A `Dual Assay Algorithm´ to identify recently acquired HIV-1 infections
V18
A. Hauser, A. Hofmann, K. Meixenberger, S. Somogyi, B. Bartmeyer, V. Bremer
C. Kuecherer, N. Bannert (Berlin/DE)
17.00–17.45
RoomVom-Stein-Haus
17.45–19.15
Workshop 4 – Viral Replication I
Room
Lecture Hall 1
Chairs
T. Schaller (Heidelberg/DE), D. Sauter (Ulm/DE)
17.45
Development and application of a novel Ebola virus replicon model that stably
V19
replicates a viral mini-genome
W. Tao, T. Gan, M. Guo, J. Zhong (Shanghai/CN)
18.00
Analysis of competing HIV-1 splice donor sites uncovers a tight cluster of
V20
splicing regulatory elements within exon 2/2b
A.-L. Brillen, L. Walotka (Düsseldorf/DE), M. Widera (Essen/DE), S. Theiss
H. Schaal (Düsseldorf/DE)
18.15
MicroRNA-99 family modulates hepatitis B virus replication by
V21
PI3K/Akt/mTOR/ULK1 signaling-induced autophagy
Y. Lin, W. Deng, J. Pang, T. Kemper, A. Squire, M. Günzer, M. Lu (Essen/DE)
p 23
18.30
V22
Quantitative lipid droplet proteome analysis identifies Annexin A3 as a cofactor
for HCV particle production
K. Rösch, M. Kwiatkowski, S. Hofmann, A. Schöbel, C. Grüttner, M. Wurlitzer
H. Schlüter, E. Herker (Hamburg/DE)
18.45
V23
19.00
V24
17.45–19.15
Room
Chairs
17.45
V26
18.00
V27
18.15
V28
18.30
V29
Host range restriction of insect-specific flaviviruses occurs at several levels of
the viral life cycle
B. Kümmerer, M. Korries (Bonn/DE), W. Grasse (Berlin/DE), S. Junglen (Bonn/DE)
p 24
Novel 3D insights into the Hepatitis A Virus (HAV)-induced replication factories
I. Romero Brey, K. Esser-Nobis, N. Schieber, Y. Schwab, R. Bartenschlager
V. Lohmann (Heidelberg/DE), R. Gosert (Basel/CH)
Workshop 5 – Innate Immunity II
Lecture Hall 3
M. Budt (Berlin/DE), F. Weber (Giessen/DE)
Murine cytomegalovirus encoded m152 perturbs STING trafficking and
degradation to antagonise the type I IFN response downstream of cGAS sensing
B. Chan, M. Stempel (Braunschweig/DE), S. Jonjic (Rijeka/HR)
M. Brinkmann (Braunschweig/DE)
A ROS and PGAM5-dependent cell death pathway involved in antiviral mmunity
C. Holze, D. Haas, C. Benda (Planegg/DE), P. Stäheli (Freiburg/DE)
A. Pichlmair (Planegg/DE)
DAPK1 – a novel regulator of the antiviral RIG-I signaling pathway identified by
Kinome-Wide siRNA screening
J. Willemsen, J. Wolanski, O. Wicht, C. Hüber (Heidelberg/DE)
B. Knapp (Greifswald/DE), D. Haas (Martinsried, Munich/DE)
L. Kaderali (Greifswald/DE), P. Matula, K. Rohr, H. Erfle (Heidelberg/DE)
J. Marcotrigiano (Piscataway, NJ/US), A. Pichlmair (Martinsried, Munich/DE)
R. Bartenschlager, M. Binder (Heidelberg/DE)
Modulation of retrovirus-specific CD8+ T cell responses by IFNα subtypes
J. Dickow, K. Gibbert, U. Dittmer (Essen/DE)
18.45
V145
19.00
V30
17.45–19.15
Room
Chairs
17.45
V31
The viral FGARAT homolog ORF75 of rhesus monkey rhadinovirus effects
proteasomal degradation of the ND10 components SP100 and PML
A. Hahn, A. Großkopf (Göttingen/DE), D. Jungnickl, B. Scholz
A. Ensser (Erlangen/DE)
18.00
V32
18.15
V33
18.30
V34
Location and role of Newcastle disease virus proteins during exocytic transport
H. Bartikowski, S. Finke, T. C. Mettenleiter
A. Römer-Oberdörfer (Greifswald, Isle of Riems/DE)
Cell type-dependent ability of Vpx alleles to modulate SAMHD1 and overcome
the restriction to HIV infection
H.-M. Baldauf (Munich/DE), L. Stegmann, S.-M. Schwarz (Frankfurt/DE)
M. Trotard (Heidelberg/DE), M. Martin (Frankfurt/DE), G. Lenzi (Atlanta, GA/US)
X. Pan (Heidelberg/DE), O. Fregoso, E. Lim (Seattle, WA/US),
L. Abraham (Heidelberg/DE), E. Erikson (Frankfurt/DE),
L. Nguyen (Atlanta, GA/US), I. Ambiel (Frankfurt/DE), B. Kim (Atlanta, GA/US)
M. Emerman (Seattle, WA/US), O. T. Fackler (Heidelberg/DE)
O. T. Keppler (Munich, Frankfurt/DE)
Workshop 6 – Virus Imaging
Lecture Hall 2
S. Boulant, B. Müller (Heidelberg/DE)
Hepatitis C virus is released via a non-canonical secretory route
K. Bayer (Munich/DE), C. Banning (Hamburg/DE), V. Bruss (Munich/DE)
G. Vieyres, T. Pietschmann (Hanover/DE), L. Wiltzer-Bach (Tübingen/DE)
M. Schindler (Tübingen, Munich, Hamburg/DE)
Site-specific labelling of human immunodeficiency virus envelope protein using
click chemistry
V. Sakin, J. Dunder, I. Nikic, H.-G. Kräusslich, E. A. Lemke
B. Müller (Heidelberg/DE)
Remodeling nuclear architecture allows efficient transport of herpesvirus
capsids by diffusion
J. B. Bosse (Hamburg/DE; Princeton, NJ/US), I. B. Hogue, M. Feric
S. Y. Thiberge (Princeton, NJ/US), B. Sodeik (Hanover/DE), C. Brangwynne
L. W. Enquist (Princeton, NJ/US)
p 25
18.45
V35
Time course of HIV-1 proteolytic maturation revealed by STED nanoscopy
J. Hanne (Heidelberg/DE), F. Göttfert (Göttingen/DE), J. Schimer (Prague/CZ)
M. Anders-Össwein (Heidelberg/DE), D. Meineke, V. Belov (Göttingen/DE)
J. Engelhardt, B. Müller (Heidelberg/DE), S. W. Hell (Göttingen, Heidelberg/DE)
19.00
V36
Ultrastructural 3D analysis of HCMV induced nuclear membrane infoldings by
FIB/SEM – Discovery of an unexpectedly complex membrane morphology
C. Villinger, G. Neusser, C. Kranz, P. Walther, T. Mertens (Ulm/DE)
19.15–21.30
Get-Together within the Industrial Exhibition
RoomVom-Stein-Haus
(please refer to page 115)
19.30–21.30
Room
p 26
Poster Session 1
Vom-Stein-Haus (SR 07, SR 10, SR 11)
(Virus Receptors and Entry, Innate Immunity I & II, Diagnostic Tools,
Viral Replication I & II)
Introducing the ARIES® System: A sample to answer
real-time PCR system that is crafted to increase
laboratory efficiency, ensure result accuracy, and
fit seamlessly into today's lean laboratory
The ARIES® System provides unprecedented flexibility and simplicity through:
• Ability to simultaneously run IVDs and LDTs (homebrew) in a single run when
using a universal protocol, with only minutes of assay prep time
• Minimized training time with an easy to learn, intuitive interface
• Reduced turnaround time with simultaneous STAT and batch testing on a
single ARIES® System
• Reduced physician wait time with electronic reporting of patient results
• Simplified workflow with Auto Run for a true walk away experience
Visit the Luminex booth to learn
more about our CE Marked
ARIES® HSV 1&2 Assay, and get
the latest news about assays
in development, such as
Flu A/B & RSV.
www.luminexcorp.com
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/
regions. Please contact Luminex at [email protected] to obtain the appropriate product
information for your country of residence. Validation of the LIS compatibility must be performed by the
end user. Some features may not be available at launch. The ARIES System is a class 1 laser product.
©2015-2016 Luminex Corporation. All rights reserved. Luminex and ARIES are trademarks of Luminex
Corporation, registered in the U.S. and other countries.
AD1441.0116
Scientific Programme • Thursday, 7 April 2016
08.30–10.00
Room
Chairs
Workshop 7 – Viral Replication II
Lecture Hall 3
O. Fackler (Heidelberg/DE), M. Brinkmann (Braunschweig/DE)
08.30
V37
Alpha-helix 2 of the multifunctional regulatory protein pUL69 mediates
Pin1-interaction and its phosphorylation is required for efficient
multiplication of human cytomegalovirus
M. Thomas, R. Mueller, G. Horn, A. Svrlanska, E. Sonntag, S. Schmidt
B. Zielke (Erlangen/DE), T. Fossen (Bergen/NO)
08.45
V38
Mutual interplay between the HCMV terminase subunits pUL51/pUL56/pUL89
for correct subnuclear localisation and terminase .complex assembly
S. Neuber (Hanover/DE), T. Goldner, P. Lischka (Wuppertal/DE)
K. Wagner, M. Messerle, E. M. Borst (Hanover/DE)
09.00
V39
The influence of a plant geminivirus Rep protein on cell cycle control mechanisms
K. Hipp, P. Rau (Stuttgart/DE), B. Gronenborn (Gif-sur-Yvette/FR)
H. Jeske (Stuttgart/DE)
09.15
V40
Usp7, an ubiquitin specific protease interacts with Merkel cell polyomavirus
Large T-Antigen and modulates viral DNA replication
M. Czech-Sioli, S. Siebels, T. Dobner, A. Grundhoff, N. Fischer (Hamburg/DE)
09.30
V41
09.45
V42
Single-cell analysis of influenza A virus-infected cells
S. Y. Kupke, F. S. Heldt, U. Reichl, T. Frensing (Magdeburg/DE)
p 28
Mutational analysis suggests that acetylation of the influenza A virus
nucleoprotein is required for correct bundling of vRNPs
S. Giese (Freiburg/DE), S. Lakdawala (Pittsburgh, PA/US)
Y. Zhao (Shanghai/CN), V. Götz, E. Moreira, A. Dudek, H. Bolte (Freiburg/DE)
Y. E. Chin, K. Xu (Shanghai/CN), M. Schwemmle (Freiburg/DE)
08.30–10.00
Room
Chairs
Workshop 8 – Adaptive Immunity I
Lecture Hall 2
I. Drexler (Düsseldorf/DE), L. Cicin-Sain (Braunschweig/DE)
08.30
V43
RNAi-mediated suppression of HBV restores HBV-specific immunity and
enhances the efficacy of therapeutic vaccination
A. Kosinska, T. Michler, C. Jaeger, N. Roeder (Munich/DE)
D. Grimm (Heidelberg/DE), M. Heikenwalder, M. Roggendorf
U. Protzer (Munich/DE)
08.45
V44
Induction of immune responses and HBsAg decline after stop of long-term
nucleos(t)ide analogue therapy in HBeAg negative patients with chronic
hepatitis B
F. Rinker, C. Höner zu Siederdissen (Hanover/DE), C. Bremer (Giessen/DE)
B. Maasoumy, B. Bremer, C. Falk, M. Manns, H. Wedemeyer (Hanover/DE)
D. Glebe (Giessen/DE), M. Cornberg, A. Kraft (Hanover/DE)
09.00
V45
CXCR3 and CCR5 selectively navigate pDC for local IFN delivery
A. Brewitz, S. Eickhoff, K. Komander, M. Ataíde, A. E. Peters (Bonn/DE)
M. Colonna (St. Louis, MO/US), C. Kurts, W. Kolanus
W. Kastenmüller (Bonn/DE)
09.15
V46
Antigen-driven proliferation of effector memory T cells maintains memory
Inflation in MCMV infection
L. Borkner, A. Drabig, T. Marandu, M. Schuster (Braunschweig/DE)
M. Jarvis (Plymouth/GB), L. Čičin-Šain (Braunschweig/DE)
09.30
V47
Role of naïve T cells in HCMV transmission
N. Subramanian, Ze. Wu, T. Mertens (Ulm/DE)
09.45
V48
HCMV-antibody complexes induce immune responses
Ze. Wu, R. Qin, C. Sinzger, Li. Wang, P. Walther, T. Mertens
G. Frascaroli (Ulm/DE)
p 29
08.30–10.00
Room
Chairs
Workshop 9 – Emerging Viruses
Lecture Hall 1
M. Beer (Greifswald, Isle of Riems/DE), J. F. Drexler (Bonn/DE)
08.30
V49
Host cell entry mediated by filoviral glycoproteins into bat and human cells
relies on the same host cell factors but entry efficiency is species dependent
M. Hoffmann, M. González Hernández, E. Berger, S. Pöhlmann (Göttingen/DE)
08.45
V50
Detection of two highly diverse bunyaviruses in neotropical mosquitoes
A. Kopp, F. Zirkel, A. Hübner (Bonn/DE), D. Hobelsberger (Berlin/DE)
A. Estrada (Mexico City/MX), I. Jordan (Berlin/DE)
T. Gillespie (Atlanta, GA/US), C. Drosten, S. Junglen (Bonn/DE)
09.00
V51
A new pegivirus causes chronic infection in domestic pigs
C. Bächlein (Hanover/DE), A. Grundhoff, N. Fischer, M. Alawi (Hamburg/DE)
D. Höltig, K.-H. Waldmann, P. Becher (Hanover/DE)
09.15
V52
Differential maturation and glycosylation of the envelope glycoprotein GN on
UGBuniemi virions derived from tick vector and mammalian host cells
M. Mazelier (Heidelberg/DE), R. Rouxel (Laval/CA), M. Zumstein (Zurich/CH)
L. Bell-Sakyi (Pirbright/GB)
P.-Y. Lozach (Heidelberg/DE; Laval/CA; Zurich/CH)
09.30
V53
Zika virus emergence in the Americas – A potential threat to Europe?
J. Schmidt-Chanasit (Hamburg/DE)
09.45
V54
Protective efficacy of recombinant modified vaccinia virus Ankara delivering
Middle East respiratory syndrome coronavirus spike glycoprotein
A. Volz (Munich/DE), A. Kupke (Marburg/DE), F. Song, S. Jany
R. Fux (Munich/DE), H. Shams-Eldin, J. Schmidt (Marburg/DE)
C. Becker (Giessen/DE), M. Eickmann, Step. Becker (Marburg/DE)
G. Sutter (Munich/DE)
10.00–10.45
RoomVom-Stein-Haus
p 30
10.45–12.15
Room
Chairs
Plenary Lecture 2 – Emerging Viruses
Lecture Hall 1
Step. Becker (Marburg/DE), J. Schmidt-Chanasit (Hamburg/DE)
10.45
Vaccine approaches for emerging viruses
H. Feldmann (Hamilton, MT/US)
11.15
Current topics in emerging viruses
Y. Kawaoka (Madison, WI/US)
11.45
Mapping the intra-hepatic distribution of hepatitis B virus in chronic hepatitis B
virus infection
Z. Yuan (Shanghai/CN)
12.15–14.00
RoomVom-Stein-Haus
12.30–13.30
Room
Lunch Symposium – Hologic Deutschland GmbH
Lecture Hall 2
12.30
Optimisation of nucleic acid testing in diagnostic virology
T. Iftner (Tübingen/DE)
13.00
Persistent infections with high risk HPV types as necessary risk factor for
cervical cancer – implications for screenings – HPV DNA or RNA Test?
M. Obermeier (Berlin/DE)
14.00–15.30
Room
Chairs
Workshop 10 – Trafficking
Lecture Hall 2
B. Klupp (Greifswald, Isle of Riems/DE), B. Sodeik (Hanover/DE)
14.00
V55
Nipah virus matrix protein nuclear trafficking is cell-type independent
M. Ringel, P. Schepsky, Bo. Lamp, A. Maisner (Marburg/DE)
14.15
V56
The intra-cellular cholesterol transport inhibitor U18666A blocks the release
of HCV particles
F. Elgner, R. Medvedev, H. Ren, K. Himmelsbach, E. Hildt (Langen/DE)
14.30
V57
Subviral HBV filaments are released like infectious viral particles via MVBs
B. Jiang, K. Himmelsbach, H. Ren, K. Boller (Langen/DE)
E. Hildt (Giessen, Marburg, Langen/DE)
p 31
14.45
V58
Transport of Marburg virus glycoprotein is associated with the recycling
endosome in non-polarised cells
S. Halwe, Step. Becker, O. Dolnik (Marburg/DE)
15.00
V59
Effect of rapid changes in PI (4,5) P2 availability on HIV-1 Gag recruitment
and assembly
F. Mücksch, V. Laketa, B. Müller, C. Schultz, H.-G. Kräusslich (Heidelberg/DE)
15.15
V60
Transfer of HTLV-1 p8 to target T-cells depends on VASP, a novel interaction
partner of p8
N. Donhauser, E. Socher, S. Millen, H. Sticht, .A. K. Thoma-Kreß (Erlangen/DE)
14.00–15.30
Room
Chairs
Workshop 11 – Adaptive Immunity II
Lecture Hall 1
T. Grunwald (Leipzig/DE), T. Gramberg (Erlangen/DE)
14.00
V61
Intravital imaging of physical interactions between regulatory and effector
T cells in a murine retrovirus model
L. Otto, A. Hasenberg, G. Zelinskyy, U. Dittmer, M. Gunzer (Essen/DE)
14.15
V62
Hominid cytomegalovirus immunoevasin US11 driven diversification of HLA-A
C. Zimmermann (Freiburg/DE), D. Kowalewski (Tübingen/DE)
V. T. K. Le-Trilling (Essen/DE), F. Momburg (Heidelberg/DE)
S. Stevanović (Tübingen/DE), H. Hengel, A. Halenius (Freiburg/DE)
14.30
V63
IL1β is a potent mucosal adjuvant in adenoviral vector immunisations to
enhance heterologous immunity against Influenza A
D. Lapuente, A. Maaske, V. Stab (Bochum/DE)
D. Hannaman (San Diego, CA/US), C. Ehrhardt (Münster/DE)
W. Bayer (Essen/DE), M. Tenbusch (Bochum/DE)
14.45
V64
Non-hematopoietic cells in memory inflation
Z. Banki (Innsbruck/AT; Oxford/GB), J. Colston, C. Willberg
L. N. Lee (Oxford/GB), J. Holzki (Braunschweig/DE)
A. E. Denton (Cambridge/GB), H. Stoiber, D. Holm-von Laer (Innsbruck/AT)
L. Cicin-Sain (Braunschweig/DE), D. T. Fearon (Cambridge/GB)
B. Ludewig (St. Gallen/CH), P. Klenerman (Oxford/GB)
p 32
15.00
V65
The C-terminus of HSV-1 encoded ICP47 is required to “freeze” the TAP
(transporter associated with antigen processing) peptide transport cycle
A. Halenius, Ju. Busch, C. Gerke, T. Matschulla, H. Hengel (Freiburg/DE)
15.15
V66
PD-L1 expression on retrovirus-infected cells mediates immune escape from
CD8 +T cell killing
I. Akhmetzyanova, M. Drabczyk (Essen/DE), C. P. Neff (Aurora, CO/US)
K. Gibbert, T. Werner (Essen/DE), Jia Liu (Essen/DE; Wuhan/CN)
K. S. Lang (Essen/DE), B. E. Palmer (Aurora, CO/US), U. Dittmer
G. Zelinskyy (Essen/DE)
14.00–15.30
Room
Chairs
Workshop 12 – Virus Vectors and Gene Therapy
Lecture Hall 3
F. Kreppel (Ulm/DE), A. Ehrhardt (Witten/DE)
14.00
V67
Regulated TRIM5α expression as a tool to prevent HIV infection
C. Elsner, T. Klause, J. Bohne (Hanover/DE)
14.15
V68
Adenovirus type 5 transduction of tumor cell lines can be substantially
increased by complex formation between virus and the chemically designed
dendrimer PPD4
L. Frank, K. Hopfensperger, Yu. Wu, T. Weil, F. Kreppel (Ulm/DE)
14.30
V69
A carbohydrate-based model to determine the in vivo fate of defined
adenovirus immune complexes
R. F. Kratzer, A. Hoffmeister, S. Espenlaub, F. Kreppel (Ulm/DE)
14.45
V70
Human adenovirus D17 has tropism for endothelium cells and can use both
hCAR and CD46 as receptors
Jin Liu, P. Boehme (Witten/DE), J. Fu (Dresden/DE), Wen. Zhang
M. Solanki (Witten/DE), R. Yumul (Seattle, WA/US), A. Schmidtko (Witten/DE)
F. Stewart (Dresden/DE), A. Lieber (Seattle, WA/US), A. Ehrhardt (Witten/DE)
15.00
V71
Efficient oncolysis of non-small-cell lung cancer tissue upon influenza A virus
infection in a lung tumor model in mice
D. Masemann (Münster/DE), K. Koether (Münster/DE; Cambridge/GB)
M. Kuhlencord, G. Varga, J. Roth (Münster/DE), B. Lichty (Hamilton/CA)
V. Wixler, S. Ludwig (Münster/DE)
p 33
15.15
V72
Augmenting the therapeutic efficacy of oncolytic LCMV-GP pseudotyped
vesicular stomatitis virus via modulation of the innate immune system
C. Rodrigez Urbiola, C. Dold, P. Erlmann, L.-M. Schreiber, H. Fiegl, C. Marth
F. Santer, Z. Culig (Innsbruck/AT), A. Muik (Frankfurt/DE), G. Wollmann
D. von Laer, J. Kimpel (Innsbruck/AT)
15.30–17.30
Coffe Break within the Industrial Exhibition
15.30–17.30
Room
Poster Session 2
Vom-Stein-Haus (Halls, SR 06)
(Adaptive Immunity I & II, Emerging Viruses, Trafficking, Virus Vectors and
Gene Therapy, Structure and Assembly, Tumor Viruses, Antiviral Therapy and
Resistance, Evolution of Viruses – Viruses in Evolution, Signal Transduction)
17.30–18.45
Room
Laudations and Presentations for the Loeffler Frosch Award and Medal
Lecture Hall 1
18.45–19.45
Room
GfV General Assembly
Lecture Hall 1
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Scientific Programme • Friday, 8 April 2016
08.30–10.00
Room
Chairs
Workshop 13 – Structure and Assembly
Lecture Hall 1
E. Steinmann (Hanover/DE), C. Uetrecht (Hamburg/DE)
08.30
V73
The HCMV terminase subunit pUL89 -new insights into structure-function
relationships
A. Holzenburg, M. W. Sung (College Station, TX/US), S. M. Lapp
E. Bogner (Berlin/DE)
08.45
V74
The inner tegument proteins pUL36 and pUL37 of herpes simplex virus are
sufficient for intracellular motility but not for targeting capsids to the axons of
dorsal root ganglia neurons
A. Buch, O. Müller, L. Ivanova, K. Döhner (Hanover/DE)
J. Bosse (Hamburg/DE), A. Pohlmann, A. Binz, M. Hegemann (Hanover/DE)
M. Koltzenburg (London/GB), B. Rosenhahn, R. Bauerfeind
09.00
Re-programming viral nucleoprotein self-assembly – Tobamovirus-based
V75
nanosticks, boomerangs and star colloids for diagnostics and technical
purposes
F. J. Eber, F. Geiger, A. Mueller, C. Koch (Stuttgart/DE)
S. Shukla (Cleveland, OH/US), C. Azucena (Eggenstein-Leopoldshafen/DE)
Zh. Wu, C. Krill III (Ulm/DE), N. F. Steinmetz (Cleveland, OH/US)
H. Gliemann (Eggenstein-Leopoldshafen/DE), H. Jeske, S. Eiben
C. Wege (Stuttgart/DE)
09.15
V76
Viral budding regulated by a critical residue located at the putative dimeric
interface of the canine distemper virus matrix protein
F. Bringolf, M. Wys, M. Herren, Z. Andreas, P. Plattet (Bern/CH)
09.30
V77
Ion-channel function and cross-species determinants in viral assembly of
nonprimate hepacivirus p7
S. Walter, A. Bollenbach, J. Doerrbecker, S. Pfaender, R. J. P. Brown
G. Vieyres (Hanover/DE), C. Scott, R. Foster (Leeds/GB), A. Kumar
N. Zitzmann (Oxford/GB), S. Griffin (Leeds/GB), F. Penin (Lyon/FR)
T. Pietschmann, E. Steinmann (Hanover/DE)
09.45
V78
Prediction of conserved long-range RNA-RNA interaction in full viral genomes
M. Fricke, M. Marz (Jena/DE)
p 36
08.30–10.00
Room
Chairs
Workshop 14 – Tumor Viruses
Lecture Hall 2
B. Biesinger (Erlangen/DE), A. Kieser (Munich/DE)
08.30
V79
Papillomavirus-associated tumor formation critically depends on c-fos
expression induced by viral protein E2 and bromodomain protein Brd4
M. Delcuratolo, J. Fertey, M. Schneider, J. Schuetz, N. Leiprecht, B. Hudjetz
S. Brodbeck, S. Corall, M. Dreer, R. M. Schwab, M. Grimm (Tübingen/DE)
S.-Y. Wu (Dallas, TX/US), F. Stubenrauch (Tübingen/DE)
C.-M. Chiang (Dallas, TX/US), T. Iftner (Tübingen/DE)
08.45
V80
The fibronectin / α3β1 integrin axis serves as molecular basis for HPV8
induced keratinocyte invasion
S. Heuser, M. Hufbauer, J. Steiger (Cologne/DE), J. Marshall (London/GB)
A. Sterner-Kock, C. Mauch, P. Zigrino, B. Akgül (Cologne/DE)
09.00
V81
A highly conserved interaction of the cellular NCOR/SMRT complex with
papillomavirus E8Ê2C proteins inhibits viral replication
M. Dreer, J. Fertey, S. van de Poel, E. Straub, J. Madlung, B. Macek
T. Iftner, F. Stubenrauch (Tübingen/DE)
09.15
V82
A comparative epigenome and transcriptome analysis of KSHV and
MHV68 latency
T. Günther (Hamburg/DE), H. Adler (Munich/DE), A. Grundhoff (Hamburg/DE)
09.30
V83
Kaposi sarcoma’s herpesvirus (KSHV) latent associated nuclear antigen
(LANA) recruits components of the cellular MRN repair complex to modulate
an innate immunity signaling pathway and viral latency
G. Mariggiò, G. Zhang, S. Koch, J. Rückert, S. Santag, T. Schulz (Hanover/DE)
09.45
V84
The Tax-inducible actin-bundling protein Fascin is required for release and
cell-to-cell transmission of human T-cell leGBemia virus type 1 (HTLV-1)
C. Gross, V. Wiesmann, T. Wittenberg (Erlangen/DE)
J. Gettemans (Ghent/BE), A. K. Thoma-Kreß (Erlangen/DE)
p 37
08.30–10.00
Room
Chairs
Workshop 15 – Antiviral Therapy and Resistance
Lecture Hall 3
R. Kaiser (Cologne/DE), S. Ciesek (Hanover/DE)
08.30
V85
New strategies for anti-hepatitis C vaccine, neutralising monocloncal antibody
and drug development
X. Zhang (Wuhan/CN)
08.45
V86
Inhibition of coronavirus 2‘-O-Methyltransferase to reduce replication and
pathogenesis via multiple mechanisms
S. Wang, C. Zeng, Y. Wang, R. Pan, Y. Chen, D. Guo (Wuhan/CN)
09.00
V87
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus
genome
D. Todt, A. Gisa (Hanover/DE), A. Radonic, A. Nitsche (Berlin/DE)
P. Behrendt, P. V. Suneetha (Hanover/DE)
S. Pischke (Hanover, Hamburg/DE), B. Bremer, R. J. P. Brown (Hanover/DE)
M. P. Manns, M. Cornberg (Hanover, Braunschweig/DE)
C. T. Bock (Berlin/DE), H. Wedemeyer (Hanover, Braunschweig/DE)
E. Steinmann (Hanover/DE)
09.15
V88
Single domain antibodies against human respiratory syncytial virus
I. Rossey, B. Schepens (Ghent/BE), J. McLellan (Hanover/DE)
B. Graham (Bethesda, MD/US), X. Saelens (Ghent/BE)
09.30
V89
Macromolecular prodrugs of as antiviral agents
A. Zelikin (Aarhus/DK)
09.45
V90
Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor
by using a novel lentiviral pseudotype (hRSVpp) system
S. Haid, C. Grethe, D. Bankwitz (Hanover/DE), T. Grunwald (Leipzig/DE)
10.00–10.45
RoomVom-Stein-Haus
p 38
10.45–12.15
Room
Chairs
Plenary Lecture 3 – Viral interaction with the host and the immune system
Lecture Hall 1
U. Dittmer (Essen/DE), S. Pöhlmann (Göttingen/DE)
10.45
Cellular tools for virus warfare
B. ten Oever (New York, NY/US)
11.15
TRIM30α is a negative regulator in DNA virus infection by targeting STING
B. Sun (Shanghai/CN)
11.45
Infection and immune control of a human tumor virus in vivo
C. Münz (Zurich/CH)
12.15–13.45
RoomVom-Stein-Haus
12.30–13.30
Lunch Symposium – Qiagen GmbH
Respiratory diseases: Diagnostics and clinical implications
Room
Lecture Hall 2
Chair
A. Plaschke-Schlütter (Hombrechtikon/CH)
12.30
Respiratory pathogens: diagnostics and epidemiology
O. Adams (Düsseldorf/DE)
12.50
Panel diagnostics of respiratory pathogens using multiplex PCR:
A field report after 2000 analysed patient samples
13.10
Respiratory pathogens: Clinical implications
A. Pettke (Münster/DE)
p 39
13.45–15.15
Room
Chairs
Workshop 16 – Evolution of Viruses – Viruses in Evolution
Lecture Hall 3
S. Pleschka (Giessen/DE), G. Kochs (Freiburg/DE)
13.45
V91
Evolution of species D human adenoviruses (HAdV-D) – Are intestinal
infections of adults the recombination factory for the huge diversity of types?
A. Heim, E. Hage (Hanover/DE), S. Bergs, U.-G. Liebert (Leipzig/DE)
14.00
V92
Evolution of infectious pancreatic necrosis virus – IPNV
K. Ulrich (Stirling/GB), M. Dilcher (Göttingen/DE), .C. Palaiokostas (Edinburgh/GB)
S. Wehner (Stirling/GB), E. Thomson (Glasgow/GB), M. Weidmann (Stirling/GB)
14.15
V93
High Resolution Method (HRM) for genotyping Bovine ephemeral fever virus
(BEFV)
Y. Stram, O. Erster (Bet Dagan/IL), R. Stram, M. Rubistein-Giuni (Berlin/DE)
B. S. Sharir, M. Van Straten (Caesarea/IL), E. Kchinich (Bet Dagan/IL)
B. Sharir (Caesarea/IL)
14.30
V94
Analysis of bat-borne Makokou virus underlines the risk of emergence of
non-conventional hantaviruses
P. T. Witkowski (Berlin/DE), J. F. Drexler, R. Kallies (Bonn/DE), M. Lickova
S. Bokorova (Bratislava/SK), G. D. Maganga (Franceville/GA)
T. Szemes (Bratislava/SK), E. M. Leroy (Franceville/GA)
D. H. Kruger (Berlin/DE), C. Drosten (Bonn/DE), B. Klempa (Berlin/DE)
14.45
V95
Minimal requirements for high virulence of non-H5/H7 avian influenza viruses
J. Veits, S. Weber, E.-S. M. Abdelwhab
T. C. Mettenleiter (Greifswald, Isle of Riems/DE)
15.00
V96
In silico prediction and experimental confirmation of HA residues conferring
enhanced human receptor specificity of H5N1 influenza A viruses
S. Schmier (Frankfurt, Melsungen/DE), A. Mostafa (Dokki/EG; Giessen/DE)
T. Haarmann (Frankfurt, Darmstadt/DE), N. Bannert (Berlin/DE)
J. Ziebuhr (Giessen/DE), V. Velkovic, U. Dietrich (Frankfurt/DE)
p 40
13.45–15.15
Room
Chairs
Workshop 17 – Signal Transduction
Lecture Hall 1
O. Planz (Tübingen/DE), C. Ehrhardt (Münster/DE)
13.45
V97
Encephalomyocarditis virus 3C protease relieves TANK inhibitory effect on
TRAF6-mediated NF-kappaB signaling through cleavage of TANK
L. Huang, Q. Liu, L. Zhang, S. Cui, C. Weng (Harbin/CN)
14.00
V98
The nuclear shuttle protein of the Abutilon mosaic virus, a ssDNA plant virus,
forms a complex with the stress granule component G3BP
B. Krenz, S. Krapp, E. Greiner, U. Sonnewald (Erlangen/DE)
14.15
V99
The Epstein-Barr virus oncogene LMP1 activates MAPKinases through
IkappaB kinase 2 (IKK2) and the oncogenic serine/threonine kinase Tpl2
K. Sterz, St. Voigt, A. Kieser (Munich/DE)
14.30
V100
Differential activation of the PI3K–Akt–mTOR pathway by the alphaviruses
Semliki Forest virus (SFV) and chikungunya virus (CHIKV) to determine
replication complex localisation
B. Thaa, R. Biasiotto, K. Eng (Stockholm/SE), M. Neuvonen (Helsinki/FI)
B. Götte, L. Rheinemann (Stockholm/SE), M. Mutso, A. Utt (Tartu/EE)
F. Varghese, G. Balistreri (Helsinki/FI), A. Merits (Tartu/EE)
T. Ahola (Helsinki/FI), G. M. McInerney (Stockholm/SE)
14.45
V101
Functional comparison of the Molluscum Contagiosum virus vFLIP MC159
with the Murine Cytomegalovirus M36/vICA and M45/vIRA proteins
J. Hüttmann, E. Krause, T. Schommartz, W. Brune (Hamburg/DE)
15.00
V102
NF-κB and interferon-β regulation by the viral oncoprotein Tio in HeLa cells
D. Weidl, J.-C. Albrecht, A. Ensser (Erlangen/DE), A. Kieser (Munich/DE)
B. Biesinger (Erlangen/DE)
p 41
13.45–15.15
Room
Chairs
Workshop 18 – Vaccines
Lecture Hall 2
M. Tenbusch (Bochum/DE), M. Müller (Vienna/AT)
13.45
V103
A multi-antigenic DNA vaccine that induces broad HCV-specific T-cell
responses in mice
J. Gummow, Yanr. Li (Woodville/AU), W. Yu (Woodville, Adelaide/AU)
T. Garrod (Woodville, North Adelaide/AU), D. Wijesundara (Woodville/AU)
A. Brennan (Melbourne/AU), R. Mullick (Bangalore/IN)
I. Voskoboinik (Melbourne/AU), B. Grubor-Bauk, E. Gowans (Woodville/AU)
14.00
V104
Out-manipulating the manipulator – development of a live attenuated human
cytomegalovirus vaccine
A. Tomic, P. R. Varanasi, E. M. Borst (Hanover/DE), M. Golemac
S. Malic (Rijeka/HR), E. M. Mischak-Weissinger (Hanover/DE), P. Riese
C. Guzman (Braunschweig/DE), A. Krmpotic, S. Jonjic (Rijeka/HR)
M. Messerle (Hanover/DE)
14.15
V105
Adeno-associated virus (AAV) vector as a vehicle for a universal influenza vaccine
D. Demminger, T. Wolff (Berlin/DE)
14.30
V106
Effective tumor-vaccination with oncolytic measles virus
S. Hutzler (Langen/DE), S. Erbar, R. A. Jabulowsky (Mainz/DE)
J. Hanauer (Langen/DE), Ö. Türeci, R. Mitnacht-Kraus, S. Kreiter
M. Diken, C. Britten, U. Sahin (Mainz/DE), M. D. Mühlebach (Langen/DE)
14.45
V107
The improved antibody response against HIV-1 after a vaccination based on
intrastructural help is complemented by functional CTL responses
M. Storcksdieck, Bochum/DE), T. Niezold (Bochum/DE)
D. Hannaman (San Diego, CA/US), H. Streeck (Essen/DE)
K. Überla (Bochum, Erlangen/DE), M. Tenbusch (Bochum/DE)
15.00
V108
Viral vector vaccines expressing nucleoprotein and phosphoprotein genes of
avian bornaviruses ameliorate homologous challenge infections in cockatiels
and common canaries
M. Olbert (Freiburg/DE), A. Römer-Oberdörfer (Greifswald, Isle of Riems/DE)
C. Herden, S. Malberg (Giessen/DE), G. Sutter (Munich/DE), P. Staeheli
D. Rubbenstroth (Freiburg/DE)
15.15–16.00
RoomVom-Stein-Haus
p 42
16.00–17.30
Room
Chairs
Workshop 19 – Viral pathogenisis and persistence
Lecture Hall 2
A. Grundhoff (Hamburg/DE), M. Trilling (Essen/DE)
16.00
V109
Serum HBV RNA is pregenome RNA present in virions and may be
associated with persistence of HBV infection and viral rebound
J. Wang, X. Huang, T. Shen, X. Chen, F. Lu (Beijing/CN)
16.15
V110
Hepatitis B virus inhibits insulin receptor signaling and impairs liver
regeneration via intracellular retention of the insulin receptor
E. Hildt (Giessen, Marburg, Langen/DE), S. Barthel, T. Heinrich
S. M. Büchner, R. Medvedev, N. Kettern (Langen/DE)
16.30
V111
HBV strengthens intrahepatic myeloid-derived cells mediated T cell tolerance
through TLR1/2 induced Kupffer cell expansion and IL-10 production
Jia Liu (Essen/DE; Wuhan/CN), X. Huang, W. Wu, R. Broering
M. Roggendorf (Essen/DE), D. Yang (Wuhan/CN), M. Lu (Essen/DE)
16.45
V112
Interaction of the Merkel Cell Polyomavirus LT-Antigen with host cell
chromatin
J. Theiß, N. Fischer, A. Grundhoff (Hamburg/DE)
17.00
V113
A novel role for a viral interferon regulatory factor during the establishment
of KSHV latency
S. Koch, M. Damas, E. Hage, J. Rückert (Hanover/DE), A. Gallo
W. Brune (Hamburg/DE), T. Schulz (Hanover/DE)
17.15
V114
Nanoparticle exposure of persistently herpesvirus-infected cells reactivates
latent virus and restores features of an acute virus infection in vitro and in vivo
C. Sattler, F. Moritz, S. Chen, B. Steer, D. Kutschke, M. Irmler, J. Beckers
P. Schmitt-Kopplin, T. Stoeger, H. Adler (Munich/DE)
p 43
16.00–17.30
Room
Chairs
Workshop 20 – Host cell factors and modulation I
Lecture Hall 1
G. Gabriel (Hamburg/DE), R. König (Langen/DE)
16.00
V25
The tumor suppressor PTEN plays a critical role in antiviral innate immunity
S. Li, M. Zhu, Y. Cao, R. Pan, D. Guo (Wuhan/CN)
16.15
V116
Importin-α3 restricts pandemic H1N1 influenza A virus infection in the
mammalian host
N. Mounogou Kouassi, S. Thiele (Hamburg/DE)
P. Resa-Infante (Grenoble/FR; Hamburg/DE), S. Bertram
G. Gabriel (Hamburg, Lübeck/DE)
16.30
V117
Novel role of the vRNP-associated multifunctional host factor ANP32B for
IFN-β induction during influenza A virus infection
L. Brunotte (Münster/DE), P. Hubel (Martinsried/DE), H. Bolte (Freiburg/DE)
A. Pichlmair (Martinsried/DE), M. Schwemmle (Freiburg/DE)
16.45
V118
Influenza A virus infection triggers IFITM3 clustering in human lung cells
S. Kummer, H.-G. Kräusslich (Heidelberg/DE)
17.00
V119
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by
PP2A
K. Schott (Langen/DE), R. Derua (Leuven/BE), J. Seifried, A. Reuter
E. Schnellbächer, H. Schmitz, C. Tondera, N. Esly (Langen/DE)
A. Brandariz-Nuñez, F. Diaz-Griffero (New York, NY/DE)
V. Janssens (Leuven/BE), R. König (La Jolla, San Diego, CA/US, Langen/DE)
17.15
V120
Viral DDB1-interacting proteins exhibit discordant DDB1 affinities and
interactomes
C. Landsberg, V. T. K. Le-Trilling (Essen/DE), D. A. Megger
B. Sitek (Bochum/DE), M. Trilling (Essen/DE)
p 44
16.00–17.30
Room
Chairs
Workshop 21 – Epidemiology and Public Health
Lecture Hall 3
B. Klempa (Berlin/DE), B. Gärtner (Homburg/Saar/DE)
16.00
V121
Increase in Chikungunya virus notifications in NRW with exposure in the
Americas 2014
A. Maisa, I. Daniels-Haardt, A. Jurke (Münster/DE)
16.15
V122
Serological prevalence of hemorrhagic fever viruses in Equatorial Africa
I. Steffen, K. Lu (San Francisco, CA/US), S. Saragosti (Paris/FR)
N. Ndembi (Abuja/NG), C. A. Brennan (Abbott Park, IL/US)
W. M. Switzer (Atlanta, GA/US), A. W. Rimoin (Los Angeles, CA/US)
G. Simmons (San Francisco, CA/US)
16.30
V123
The Respiratory Virus Network – an initiative to collect and provide data on
respiratory virus diseases via internet
R. Kaiser, M. Neumann-Fraune, E. Knops, M. Timmen-Wego (Cologne/DE)
B. Gärtner (Homburg/Saar/DE), O. Adams (Düsseldorf/DE)
16.45
V124
Human infections by non-rodent associated hantaviruses in Africa
P. Heinemann, P. T. Witkowski (Berlin/DE), S. Essbauer (Munich/DE)
N. Krüger (Berlin/DE), C. G. Akoua-Koffi, F. Schaumburg (Münster/DE)
F. H. Leendertz, D. H. Krüger (Berlin/DE)
17.00
V125
Control and response measures under ILI, ARI and SARI surveillance
system in Moldova
C. Spinu, V. Eder, P. Scoferta, R. Cojocaru, I. Spinu, I. Gostev
A. Donos (Chisinau/MD)
17.15
V126
Cytomegalovirus seroprevalence among children and adolescents in Germany:
Data from the KiGGS interview and examination survey, 2003–2006
Se. Voigt, A. Schaffrath Rosario, A. Mankertz (Berlin/DE)
17.30–19.30
Room
Poster Session 3
Vom-Stein-Haus (SR 116, SR 118)
Vaccines, Viral Pathogenesis and Persistence, Host Cell Factors and
Modulation I & II, Epidemiology and Public Health, Zoonoses, Clinical Virology
20.00–01.00
Social Evening
(please refer to page 115)
p 45
Scientific Programme • Saturday, 9 April 2016
08.30–10.00
Room
Chairs
Workshop 22 – Zoonoses
Lecture Hall 1
T. W. Vahlenkamp (Leipzig/DE), M. A. Müller (Bonn/DE)
08.30
V127
Variegated squirrel 1 bornavirus (VSBV-1) – a novel zoonotic pathogen
B. Hoffmann (Greifswald, Isle of Riems/DE), D. Tappe (Hamburg/DE)
D. Hoffmann, D. Höper (Greifswald, Isle of Riems/DE)
C. Herden (Giessen/DE), K. Schlottau, M. Jenckel, T. Homeier-Bachmann
J. P. Teifke, C. Fast (Greifswald, Isle of Riems/DE), S. Herzog (Giessen/DE)
D. Cadar, J. Schmidt-Chanasit (Hamburg/DE), R. Ulrich
M. Beer (Greifswald, Isle of Riems/DE)
08.45
V128
Alimentary tract as entry route for hantavirus infection
P. T. Witkowski, C. Jürgensen, A. Petrich, J.-D. Schulzke, D. H. Krüger
R. Bücker (Berlin/DE)
09.00
V129
H5N1 highly pathogenic avian influenza A virus outbreak among poultry in
Ghana – 2015
I. A. Asante (Hamburg/DE; Accra/GH), S. Bertram (Hamburg, Lübeck/DE)
J. Awuni, A. N. O. Commey, W. K. Ampofo (Accra/GH)
G. Gabriel (Hamburg, Lübeck/DE)
09.15
V130
Virological characterisation of a newly established pig breed, Aachen Minipigs
E. Plotzki (Berlin/DE), G. Heinrichs (Heinsberg/DE), B. Kubícková
R. G. Ulrich (Greifswald, Isle of Riems/DE), J. Denner (Berlin/DE)
09.30
V131
Evolution and antiviral specificity of rodent Mx proteins
B. Muether (Freiburg/DE), L. Radosa (Berlin/DE), I. Eckerle (Bonn/DE)
M. Hölzer, M. Marz (Jena/DE), S. Drewes, M. Lenk
R. Ulrich (Greifswald, Isle of Riems/DE), D. Krüger, B. Klempa (Berlin/DE)
09.45
V132
Co-circulation of sandfly-transmitted phleboviruses and Leishmania infantum
in a zoonotic visceral leishmaniais focus located in arid bio-geographical
areas Central Tunisia
W. Fares, K. Dachraoui, W. Barhoumi, S. Cherni, S. Sakhria, W. Fraihi
I. Chelbi (Tunis/TN), J. Clos (Hamburg/DE), Stefanie Becker (Hanover/DE)
E. Zhioua (Tunis/TN)
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08.30–10.00
Room
Chairs
Workshop 23 – Host Cell Factores and Modulation II
Lecture Hall 2
A. Karlas (Berlin/DE), C. Claus (Leipzig/DE)
08.30
V133
Modulation of cellular metabolism by rubella virus is strain-specific and targets
mitochondrial activity and glycolysis
C. Claus, A. Lüdtke, K. Jahn (Leipzig/DE), J. Hübschen (Luxembourg/LU)
U. G. Liebert (Leipzig/DE)
08.45
V134
PIAS2 and PIAS1, novel interaction partners of Ebola and Marburg virus
VP30, negatively regulate transcription and replication of filoviruses
M. Klüver, Step. Becker (Marburg/DE)
09.00
V135
Deciphering the interactions between yellow fever virus and the human
immune system
F. Douam, G. Hrebikova, Q. Ding, A. Ploss (Princeton, NJ/US)
09.15
V136
A host genome-wide loss-of-function screen reveals effective chikungunya
antiviral drugs
A. Karlas (Berlin/DE), S. Berre, T. Couderc (Paris/FR), M. Varjak (Tartu/EE)
P. Braun, M. Meyer (Falkensee/DE), N. Gangneux (Paris/FR)
L. Karo-Astover (Tartu/EE), U. Klemm (Berlin/DE), A. Wurzlbauer
F. Bracher (Munich/DE), A. Merits (Tartu/EE), T. F. Meyer (Berlin/DE)
M. Lecuit (Paris/FR)
09.30
V137
KAP1 is a host restriction factor that promotes human adenovirus (HAdV)
E1B-55K SUMO modification
C. Bürck (Hamburg/DE), A. Mund (Copenhagen/DE), J. Berscheminski
L. Kieweg (Hamburg/DE), S. Müncheberg
S. Schreiner (Hamburg, Munich/DE), T. Dobner (Hamburg/DE)
09.45
V138
Severe beta-HPV infection and skin cancer in genetically predisposed
individuals with EV3 deficiency
S. J. de Jong, A. Crequer (New York, NY/US), L. Lorenzo
J.-H. Fabienne (Paris/FR), A. A. Arias (Medellin/CO), P. M. Nataly
R. C. Xavier (Bogota/CO), F. Jose Luis (Medellin/CO), V. K. Gunasekharan
L. Laimins (Chicago, IL/US), E. Imahorn, B. Burger (Basel/CH)
G. Orth (Paris/FR), E. Jouanguy, J.-L. Casanova (New York, NY/US; Paris/FR)
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08.30–10.00
Room
Chairs
Workshop 24 – Clinical Virology
Lecture Hall 3
J. Kühn (Münster/DE), J. Verheyen (Essen/DE)
08.30
V139
Identification of a new Enterovirus 71 genogroup C variant emerging in DE, 2015
S. Böttcher, P. Obermeier, K. Neubauer, S. Diedrich (Berlin/DE)
and on behalf of the LaNED
08.45
V140
Interim rsults of a phase Ib/IIa study of the entry inhibitor myrcludex B in
chronic hepatitis D infected patients
P. Bogomolov (Moscow/RU), A. Alexandrov (Bad Homburg/DE)
N. Voronkova, M. Macievich, K. Kokina, M. Petrachenkova (Moscow/RU)
T. Lehr (Saarbrücken/DE), F. A. Lempp (Heidelberg/DE)
H. Wedemeyer (Hanover/DE), M. Haag, M. Schwab (Stuttgart/DE)
W. E. Haefeli, A. Blank, S. Urban (Heidelberg/DE)
09.00
V141
CMV particles mediate acute myeloid leGBaemia cell death via soluble
factors irrespective of viral gene expression
L. Rink, V. T. K. Le-Trilling, M. Trilling (Essen/DE)
09.15
V142
Multiple virus infections in pediatric allogeneic transplant recipients including
Adeno-, Cytomegalo-and Epstein-Barr virus reactivations
Se. Voigt, J.-S. Kühl, J. Hofmann, W. Ebell (Berlin/DE)
09.30
Nona-valent HPV-vaccination could potentially prevent the majority of
V143
(pre)malignant anogenital lesions in HIV-positive men
U. Wieland, M. Hellmich, S. Silling (Cologne/DE)
N. Brockmeyer (Bochum/DE), H. Pfister (Cologne/DE)
A. Kreuter (Oberhausen/DE)
09.45
V144
Treatment of HIV and acute myeloid leGBemia by allogeneic CCR5-d32 blood
stem cell transplantation
B. Jensen (Düsseldorf/DE), E. Knops (Cologne/DE)
N. Luebke (Düsseldorf/DE), G. Dunay (Hamburg/DE)
R. Kaiser (Cologne/DE), R. Haas, D. Häussinger, G. Kobbe (Düsseldorf/DE)
10.00–10.45
RoomVom-Stein-Haus
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10.45–12.15
Room
Chairs
Plenary Lecture 4 – Evolution of Viruses – Viruses in Evolution
(organised in cooperation with the Münster Graduate School
of Evolution (MGSE))
Lecture Hall 1
P. Stäheli (Freiburg/DE), C. Leib-Mösch (Neuherberg/DE)
10.45
Mechanisms and consequences of RNA virus micro-evolution
R. Andino (San Francisco, CA/US)
11.15
Reverse genetic analysis of the newly discovered bat influenza A-like viruses
11.45
Paleovirology and our 100-million-year co-evolution with endogenous
retroviruses
R. Belshaw (Plymouth, Devon/GB)
12.15–12.45
Room
Poster Prizes & Farewell
Lecture Hall 1
p 49
Postersessions • Vom-Stein-Haus – Schlossplatz 34
Posters will be displayed during the whole duration of the conference.
The following topics will be included in the respective sessions:
Poster Session 1
Date and Time
Wednesday, 6 April 2016 • 19.30–21.30
Topics
Innate Immunity I & II
Diagnostic Tools
Viral Replication I & II
RoomsNumbers
SR07, basement
P1–P36
SR10, basement
P38–P68
SR11, basement
P69–P85
SR11, basement
P86–P111
Poster Session 2
Date and Time
Thursday, 7 April 2016 • 15.30–17.30
Topics
Adaptive Immunity I & II
Emerging Viruses
Trafficking
Tumor Viruses
Antiviral Therapy and Resistance
Evolution of Viruses –
Viruses in Evolution
Signal Transduction
RoomsNumbers
hall, basement
P112–P125
hall, basement
P126–P140
SR06, basement
P141–P144
SR06, basement
P145–P149
SR06, basement
P150–P172
SR06, basement
P173–P179
SR06, basement
P180–P217
hall, ground floor
hall, ground floor
P218–P225
P226–P230
Poster Session 3
Date and Time Friday, 8 April 2016 • 17.30–19.30
Topics
Vaccines
Host Cell Factors and Modulation I & II
Zoonoses
Clinical Virology
RoomsNumbers
SR116, first floor
P231–P256
SR116, first floor
P257–P289
SR118, first floor
P290–P338
SR116, first floor
P339–P343
SR116, first floor P344–P347
SR118, first floor
P348–P366
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Poster Session 1 • Virus Receptors and Entry
P1
Identification and characterisation of a receptor midgut protein for begomovirus in
Bemisia tabaci
V. S. Rana, S. Popli, G. K. Saurav, R. Rajagopal (Delhi/IN)
P2
Susceptibility of human pulmonary cells to Old World Hantaviruses
A. Müller, A. Baumann, M. Zeier, E. Krautkrämer (Heidelberg/DE)
P3
Identification of key residues in canine distemper virus attachment protein regulating
host cell entry
M. Herren, F. Bringolf, M. Wyss, P. Plattet (Bern/CH)
P4
Species-specific and inter-individual differences in Nipah virus receptor expression
influence NiV infection of primary airway epithelial cells from pigs and humans
L. Sauerhering, M. Zickler, M. Elvert, T. Matrosovich, M. Matrosovich
A. Maisner (Marburg/DE)
P5
Hyperfusogenic mutations in PrV glycoprotein gB – in search of the super-fuser
M. Vallbracht, C. Schröter (Greifswald, Isle of Riems/DE), J. Kühn (Münster/DE)
B. G. Klupp, T. C. Mettenleiter (Greifswald, Isle of Riems/DE)
P6
Species-specific domains of CD81 required by hepatitis C virus for cell entry
P. Banse, J. Bruening, S. Kahl, T. Pietschmann, G. Gerold (Hanover/DE)
P7
Human Norovirus GII.4 capsid protein contains multiple sialic acid and histo-blood group
antigen binding sites
H. Wegener, A. Mallagaray (Lübeck/DE), J. Lockhauserbäumer, C. Uetrecht (Hamburg/DE)
G. Hansman (Heidelberg/DE), T. Peters, S. Taube (Lübeck/DE)
P8
Flavivirus binding to cells
D. Haslwanter, D. Blaas, J. Blazevin, F. X. Heinz, K. Stiasny (Vienna/AT)
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P9
Flavivirus E protein stem interactions in virus entry
I. Medits, F. X. Heinz, K. Stiasny (Vienna/AT)
P11
A conserved eph receptor binding site in the N-terminal domain of the gH/gL glycoprotein
complexes of Kaposi’s sarcoma-associated herpesvirus and the related rhesus monkey
rhadinovirus
A. Großkopf (Göttingen/DE), A. Ensser, R. Desrosiers (Erlangen/DE)
A. Hahn (Göttingen/DE)
P12
TMPRSS11A and HAI-1 -a novel activator and inhibitor of influenza virus hemagglutinin
proteolytic cleavage
P. Zmora, A.-S. Moldenhauer, S. Pӧhlmann (Göttingen/DE)
P13
Superinfection exclusion during infection with African swine fever virus
G. Keil, R. Potugal (Greifswald, Isle of Riems/DE)
P14
Functional relevance of the N-terminal domain of pseudorabies virus envelope glycoprotein
H and its interactions with glycoprotein L
W. Fuchs, S. Rehwaldt, M. Vallbracht, C. Schröter, B. G. Klupp
T. C. Mettenleiter (Greifswald, Isle of Riems/DE)
P15
Early phlebovirus host cell interactions using Uukuniemi virus as a model
A. Hoffmann, P.-Y. Lozach, H. Fleckenstein, N. Brady, V. Lang (Heidelberg/DE)
P16
Branched actin polymerisation regulated by WASH is required for vesicle scission during
papillomavirus endocytosis
L. Kühling, P. Brinkert, C. Bannach, L. Greune, A. Schmidt, M. Schelhaas (Münster/DE)
P17
The tetraspanins CD151 and CD9 are novel host factors during initial events of human
cytomegalovirus infection
D. Hochdorfer (Ulm/DE), L. Florin (Mainz/DE), C. Sinzger, D. Lieber (Ulm/DE)
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P18
Entry of bat-associated influenza A viruses is restricted to bat cells, depends on
endosomal low pH and proteolytic activation of the hemagglutinin-like protein but does
not require canonical FLUAV receptors
M. Hoffmann (Göttingen/DE), N. Krüger (Hanover/DE), P. Zmora
F. Wrensch (Göttingen/DE), G. Herrler (Hanover/DE), S. Pöhlmann (Göttingen/DE)
P19
Mapping of amino acid residues controlling fusion activity within the N-terminal part of
the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B
M. Vallbracht (Greifswald, Isle of Riems/DE), T. Schräder, A. Krüger, A. Hofemeier
E. Lorentzen, M.-L. Romberg, W. Hafezi, J. Kuehn (Münster/DE)
P20
The contribution of cellular receptors to herpes simplex virus type 1 entry into skin cells
K. Thier, P. Petermann, D. Knebel-Mörsdorf (Cologne/DE)
P21
Hemagglutinin compensatory mutations provide new insights in virus-receptor interactions
B. Sawatsky (Langen/DE), R. Cattaneo (Rochester, NY/US), V. von Messling (Langen/DE)
P22
The cytoskeletal adaptor protein obscurin-like 1 interacts with L2 and is required for
HPV16 endocytosis
E. Wüstenhagen, L. Hampe, F. Boukhallouk, M. A. Schneider, G. A. Spoden
L. Florin (Mainz/DE)
P23
Comparative study of Lassa virus replication in immortalised cells and in primary cells
derived from the human airway epithelium
H. Müller, S. K. Fehling, J. Koepke, T. Strecker (Marburg/DE)
P24
The fusion and hemagglutinin-neuraminidase protein of a bat-derived paramyxovirus
show functional similarities to human mumps virus
N. Krüger (Hanover/DE), M. Hoffmann (Göttingen/DE), J. F. Drexler, M. Müller (Bonn/DE)
C. Sauder, S. Rubin (Silver Spring, MD/US), C. Örvell (Stockholm/SE)
C. Drosten (Bonn/DE), G. Herrler (Hanover/DE)
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P25
Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial
compound library
J. Martin, S. Beck, T. Weidner (Langen/DE), J. Herrmann (Saarbrücken/DE), C. Weber
B. Schnierle (Langen/DE)
P26
NTCP is the key host factor restricting hepatitis B virus infection in macaques and pigs
F. Lempp (Heidelberg/DE), P. Roques (Paris/FR), E. Wiedtke (Heidelberg/DE)
I. Chemin (Lyon/FR), F. Vondran (Hanover/DE), D. Grimm (Heidelberg/DE)
R. Le Grand (Paris/DE), S. Urban (Heidelberg/DE)
P27
Cell entry of human papillomavirus type 16 requires an unconventional trafficking route to
the trans-Golgi-network via late endosomes
P. Samperio Ventayol, M. Schelhaas (Münster/DE)
P28
Human coronavirus OC43 entry is caveolin-1-dependent
K. Kosowicz, K. Pyrc (Krakow/PL)
P29
Conformational changes in the capsid contribute to asynchronous uptake of human
papillomavirus type 16 by endocytosis
M. Becker, L. Greune, M. A. Schmidt, M. Schelhaas (Münster/DE)
P30
Importance of the GXXXA motif in the Ebolavirus GP transmembrane domain for entry
and sensitivity towards host-cell encoded antiviral factors
M. Gonzalez Hernandez, M. Hoffmann, S. Pöhlmann (Göttingen/DE)
P31
Characterisation of the susceptibility of the Chikungunya virus glycoprotein-mediated cell
entry process to pharmacological and immunological inhibition and cellular restriction
Se. Franz, S. Dapa (Hanover/DE), G. Simons (San Francisco, CA/US)
M. Brönstrup (Braunschweig/DE), C. Goffinet (Hanover/DE)
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P32
The coxsackievirus and adenovirus receptor – impact of glycosylation and the
extracellular D2 domain on coxsackievirus B3 infection
S. Pinkert, J. Kurreck (Berlin/DE), J. Bergelson (Philadelphia, PA/US), H. Fechner (Berlin/DE)
P33
SEVI and semen prolong the half-life of HIV-1
J. Müller, J. Münch (Ulm/DE)
P34
The Ephrin A2 receptor tyrosin kinase (EphA2) is downregulated by the KSHV
immediate-early transactivator RTA
F. Neipel, M. Fischer, A. Holzer (Erlangen/DE)
P35
Visualising the entry of a Picornaviridae, Coxsackievirus A16, into host cells occurs via
clathrin-mediated endocytosis through quantum dot-based single-particle tracking
Y. Xiong, L. Jia, B. Tang, F. Liu, Yingl. Liu, K. Wu, D. Pang (Wuhan/CN)
P36
Specific glycans increase the success of viral infections – native MS reveals glycan
mediated structural changes during cell attachment
H. Yan, J. Lockhauserbäumer (Hamburg/DE), H. Wegener, A. Mallagaray, S. Taube
T. Peters (Lübeck/DE), G. Hansman (Heidelberg/DE), C. Uetrecht (Hamburg/DE)
Poster Session 1 • Innate Immunity I & II
P38
Nucleic-acid binding proteins with antiviral activity across different species
M. Habjan (Martinsried/DE), C. Meignin (Strasbourg/FR), R. E. Boulos
J. Colinge (Montpellier/FR), J.-L. Imler (Strasbourg/FR), A. Pichlmair (Martinsried/FR)
P39
Allelic variations in the human MxA protein affect its antiviral activity
L. Graf, F. Sendker (Freiburg/DE), A. Dick (Berlin/DE), E. Barth, M. Marz (Jena/DE)
O. Daumke (Berlin/DE), G. Kochs (Freiburg/DE)
p 55
P40
KIR3DL1 in combination with HLA-Bw4-80T is associated with superior functionality of
NK cells and spontaneous immune control of HCV infection in people who inject drugs
T. Senff, C. Thöns (Düsseldorf/DE), T. Hydes (Southampton/GB), F. Heinemann, A. Heinold
M. Heilmann (Essen/DE), M. Uhrberg (Düsseldorf/DE), N. Scherbaum (Essen/DE)
S. Khakoo (Southampton/GB), J. Timm (Düsseldorf/DE)
P41
The role of Toll-like receptors in detection of MHV68 in vitro and in vivo
S. Murthy, K. A. Bussey, B. Chan, E. Reimer, G. Wolf, C. Standfuß-Gabisch
M. M. Brinkmann (Braunschweig/DE)
P42
Contribution of herpes virus persistence to inflammatory pathology in the aging host
Xi. Zheng (Braunschweig/DE)
P43
The mammalian response to virus infection is independent of small RNA silencing
S. Backes (Mainz/DE), B. ten Oever (New York, NY/US)
P44
Primary human hepatocytes exhibit toll-like receptor 2 activation upon infection with cell
culture-derived Hepatitis B virus
R. Broering, Zhe. Zhang, M. Trippler, C. Real, M. Werner, G. Gerken (Essen/DE)
J. Schlaak (Essen, Duisburg/DE), M. Lu (Essen/DE)
P45
The MCMV tegument protein M35 evades the type I IFN response via interaction with
regulatory proteins associated with RNAPII-mediated transcription of antiviral genes
V. G. Magalhaes, B. Chan (Braunschweig/DE), N. A. W. Lemmermann (Mainz/DE)
V. Juranic Lisnic, S. Jonjic (Rijeka/HR), M. J. Reddehase (Mainz/DE), O. Becherel
M. Larvin (Brisbane/AU), M. Brinkmann (Braunschweig/DE)
P46
TRIM19/PML restricts HIV infection in a cell type-dependent manner
B. Volkmann (Erlangen, Bonn/DE), T. Kahle, K. Eissmann, A. Herrmann (Erlangen/DE)
S. Schmitt (Erlangen, Bonn/DE), S. Wittmann, L. Merkel, N. Reuter, T. Stamminger
p 56
P48
RNA sensing induces a novel restriction to HIV infection in monocytes
H. Hofmann, B. Vanwalscappel, N. Bloch, N. Landau (New York, NY/US)
P49
Activation of type I and III interferon response by mitochondrial and peroxisomal MAVS
and inhibition by hepatitis C virus
S. Bender, A. Reuter, F. Eberle, E. Einhorn, M. Binder, R. Bartenschlager (Heidelberg/DE)
P50
E3 ubiquitin ligase and SUMO binding activity of KSHV-encoded RTA are crucial
mediators of Toll-like receptor degradation
H. Todt, K. Bussey, M. Brinkmann (Braunschweig/DE)
P51
Antiviral activity of different interferon (sub-) types against hepatitis E virus replication
D. Todt (Hanover/DE), C. François (Amiens/FR), Anggakusuma, P. Behrendt, M. Engelmann
L. Knegendorf, G. Vieyres, H. Wedemeyer (Hanover/DE), R. Hartmann (Aarhus/DK)
T. Pietschmann (Hanover/DE), G. Duverlie (Amiens/FR), E. Steinmann (Hanover/DE)
P52
Intercellular transfer of cGAS-dependent innate immunity in the context of HIV-1 Env
glycoprotein-mediated cell-cell fusion
S. Xu, A. Ducroux, A. Ponnurangam (Hanover/DE), T. Zillinger (Bonn/DE), A. Malassa
E. Ewald (Hanover/DE), V. Hornung (Munich/DE), W. Barchet (Bonn/DE)
C. Goffinet (Hanover/DE)
P53
Antiviral RNAi response in vector and non-vector cells against orthobunyaviruses
I. Dietrich, X. Shi, M. McFarlane (Glasgow/GB), M. Watson (Edinburgh/GB)
A.-L. Blomström (Glasgow/GB; Uppsala/SE), J. K. Skelton, R. M. Elliott, A. Kohl
E. Schnettler (Glasgow/GB)
P54
Establishment and characterisation of well-differentiated bat airway epithelial cell
cultures
R. Dijkman, H. R. Jonsdottir (Bern/CH), A. Moreira-Soto
E. Corrales-Aguilar (Costa Rica/CR), M. Schwemmle (Freiburg/DE), V. Thiel (Bern/CH)
p 57
P55
Measles virus stimulates NK cell infiltration into infected tissue, but not NK cell activity
V. Scheuplein (Langen/DE), S. Weil (Mainz/DE), J. Hanauer, A. H. Fiedler (Langen/DE)
J. Koch (Mainz/DE), M. D. Mühlebach (Langen/DE)
P56
A method pipeline for the detection of positively selected sites in silico – exemplarily
shown for bat Mx1
M. Hölzer (Jena/DE), J. Fuchs, G. Kochs (Freiburg/DE), M. Marz (Jena/DE)
P57
The human cytomegalovirus IE1 protein antagonises ND10-mediated intrinsic immunity
via the inhibition of PML de novo SUMOylation
E.-M. Schilling, M. Scherer, S. Klingl, J. Schweininger, J. Stump, Y. Muller, H. Sticht
P58
Perspectives of a HSV-1 d106S-based melanoma therapy
S. Thomann, J. B. Boscheinen (Erlangen/DE), E. Klapproth, A. Rohrhofer (Regensburg/DE)
S. Groß, B. Schuler-Thurner (Erlangen/DE), B. Schmidt, M. Werner-Klein
P. Schuster (Regensburg/DE)
P59
Differential activation of Toll-like receptor 3 by Hepatitis C and Hepatitis A virus
K. Esser-Nobis, O. Grünvogel, V. Lohmann (Heidelberg/DE)
P60
Viral suppressors of RNA silencing affect cellular RNA silencing in plant
R. Pertermann, T. Selvaraj, T. Gursinsky, J. Schuck, S.-E. Behrens (Halle/Saale/DE)
P61
IL-6 induction and regulation during influenza A virus and Staphylococcus aureus
co-infection
C. Klemm (Münster/DE), B. Löffler (Jena/DE), G. Peters, S. Ludwig
C. Ehrhardt (Münster/DE)
P62
A single nucleotide polymorphism located in the HLA-C promoter region and determining
HLA-C expression levels is associated with protection from Hepatitis C virus infection
F. M. Heinemann (Essen/DE), C. Thöns (Düsseldorf/DE), M. Lindemann, S. Ross, P. A. Horn
N. Scherbaum (Essen/DE), J. Timm (Düsseldorf/DE), A. Heinold (Essen/DE)
p 58
P63
The receptor binding domain and appropriate N-linked glycosylation of the Ebola virus
glycoprotein are required for tetherin counteraction
C. Brinkmann, I. Nehlmeier (Göttingen/DE), J. Nehls, M. Schindler (Munich/DE)
K. Walendy-Gnirß, S. Pöhlmann (Göttingen/DE)
P64
Investigation of the cytosolic cGAS-mediated DNA sensing pathway in T-cells of mouse
and human origin
A. Ponnurangam, C. Goffinet (Hanover/DE)
P65
The efficiency of virion incorporation of Env can determine SIV sensitivity to inhibition by
IFITMs
F. Wrensch, S.Gärtner, U. Sauermann, M. Winkler, S. Pöhlmann (Göttingen/DE)
P66
Cleavage of MAVS and interference with innate immune signaling is conserved among
hepaciviral NS3/4A proteases
Anggakusuma, R. Brown, D. Banda, M. Engelmann, E. Steinmann
P67
Development of a FACS-FRET assay to analyse IFITM-IFITM interactions
F. Wrensch, P. Bosch, M. Knoth, S. Gärtner (Göttingen/DE), M. Schindler (Tübingen/DE)
S. Pöhlmann, M. Winkler (Göttingen/DE)
P68
Modified vaccinia virus Ankara induces CXCL2 but not CCL2 in alveolar macrophage
MH-S cells
M. H. Lehmann, P. J. R. Price, C. Brandmüller, G. Sutter (Munich/DE)
p 59
Poster Session 1 • Diagnostic Tools
P69
Glucose detection using modified tobacco mosaic virus (TMV) particles as enzyme carriers
C. Koch (Stuttgart/DE), M. Bäcker (Aachen/DE), S. Eiben, F. Geiger (Stuttgart/DE)
H. Gliemann (Karlsruhe/DE), A. Poghossian, M. Schöning (Aachen/DE)
C. Wege (Stuttgart/DE)
P70
Exploring the virome of cattle with non-suppurative encephalitis of unknown etiology by
metagenomics
D. Wüthrich, C. Boujon, L. Truchet, S. Selimovic-Hamza, A. Oevermann, I. Bouzalas
R. Bruggmann, T. Seuberlich (Bern/CH)
P71
Comparison of 2 molecular assays designed for the quantification of HIV-1 in plasma samples
A. Berger, M. Stürmer (Frankfurt a. M./DE), J. Becker (Frankfurt/DE), O. T. Keppler (Munich/DE)
P72
Comparative analysis of different HBV-genotypes – establishment of a recombinant
HBsAg panel
M. Hassemer, M. Finkernagel (Langen/DE), K.-H. Peiffer (Frankfurt a. M./DE)
D. Glebe (Giessen/DE), M. Chudy, C. M. Nübling, S. Akhras (Langen/DE)
E. Hildt (Langen, Giessen, Marburg, Langen/DE)
P73
New immunological methods for the detection of porcine herpesviruses
E. Plotzki, M. Keller, D. Ivanusic, B. Ehlers, J. Denner (Berlin/DE)
P74
Evaluation of two versions of a 4th generation HIV-rapid test (Alere™) for the detection of
acute HIV infections
H. Rabenau, I. Friedrichs, A. Berger (Frankfurt a. M./DE), D. Münstermann
A. Lucht (Bad Salzuflen/DE), O. Keppler (Frankfurt a. M./DE)
P75
Development of a protocol for simultaneous Hepatitis C Virus genotyping and resistance testing
M. Bergmann, J. Camdereli, D. Häussinger, H. Bock, A. Walker, J. Timm (Düsseldorf/DE)
P76
Serological testing of Hepatitis E – Evaluation of four different serological Hepatitis E assays
I. Friedrichs, O. T. Keppler, H. F. Rabenau, A. Berger (Frankfurt/DE)
p 60
Poster Session 1 • Diagnostic Tools
P77
Validation of Illumina next generation sequencing for the molecular surveillance of
recently acquired HIV-1 infections in Germany using dried serum spots
K. Meixenberger, B. Altmann, A. Hauser, K. Hanke, C. Kuecherer, N. Bannert (Berlin/DE)
P78
Plant virus-based nanopores for novel types of bio-inorganic hybrid membranes
K. Altintoprak (Stuttgart/DE), A. Seidenstücker (Ulm/DE), A. Welle, P. Krolla-Sidenstein
H. Gliemann (Karlsruhe/DE), A. Plettl, O. Marti (Ulm/DE), C. Wege (Stuttgart/DE)
P79
Diagnostic assay development based on recombinant Theiler’s Murine Encephalomyelitis
Virus (TMEV) expressed proteins
K. Meissner, T. Vahlenkamp (Leipzig/DE)
P80
Occurrence of goose hemorragic polyomavirus in waterfowl and wild birds in Germany
K. Heenemann (Leipzig/DE), A. Hlinak (Frankfurt (Oder)/DE), T. Vahlenkamp (Leipzig/DE)
P82
A cross-reactive monoclonal antibody raised against recombinant hepatitis E virus
genotype 3 capsid antigen
B. Kubickova (Greifswald/DE), J. Schenk (Potsdam/DE)
K. Marcinkeviciute (Greifswald/DE; Vilnius/LT), J. Reetz (Berlin/DE), P. Dremsek (Greifswald/DE)
P. L. Tamosiunas, R. Petraityte-Burneikiene (Vilnius/LT), J. F. Drexler (Bonn/DE)
A. Andersson (Berlin/DE), D. Becher, M. H. Groschup (Greifswald/DE), F. Sellrie (Potsdam/DE)
R. Johne (Berlin/DE), R. Ulrich (Greifswald/DE)
P83
Pitfalls in PCR troubleshooting – Expect the unexpected?
L. Schrick, A. Nitsche (Berlin/DE)
P84
The potential of Droplet Digital PCR technology for the quantification of HIV-1 proviral
DNA and replication competent virus in different CD4+ subsets
G. Dunay, A.-D. Hüfner, O. Degen, E. Tolosa, J. Hauber, J. Schulze zur Wiesch (Hamburg/DE)
P85
Development of a rapid detection method for viral infections by use of an optical biosensor
technology
D. Vollandt, P. Patel, P. Prüger (Berlin/DE), A. Hartjes, G. Markovic, F. Pröll
G. Proll (Tübingen/DE), M. Niedrig (Berlin/DE)
p 61
Poster Session 1 • Viral Replication I & II
P86
Generation of a TB40/E-derived human cytomegalovirus genome with an intact US region
and a self-excisable BAC cassette
K. Laib Sampaio, M. Abdellatif, C. Sinzger (Ulm/DE)
P87
Time course of HIV-1 early post-entry events in human monocyte-derived macrophages
D. Bejarano, K. Peng, K. Börner, B. Müller, H.-G. Kräusslich (Heidelberg/DE)
P88
Functional dissection of alternatively spliced herpesvirus genes by splice site
mutagenesis
T. Schommartz (Hamburg/DE), S. Loroch (Dortmund/DE), M. Alawi
A. Grundhoff (Hamburg/DE), A. Sickmann (Dortmund/DE), W. Brune (Hamburg/DE)
P89
Novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus
A. W. Whisnant (Würzburg/DE; Durham, NC/US), T. Kehl, Q. Bao (Heidelberg/DE)
M. Materniak, J. Kuzmak (Pulawny/PL), M. Löchelt (Heidelberg/DE)
B. R. Cullen (Durham, NC/US)
P90
The pestiviral NS4A kink domain is a dynamic regulator of RNA replication and virion
morphogenesis
D. Dubrau (Lübeck/DE), M. A. Tortorici (Paris/FR), O. Klemens (Lübeck/DE)
F. Rey (Paris/FR), N. Tautz (Lübeck/DE)
P91
A conserved influenza A virus NP code regulates viral genome packaging
M. Juozapaitis, E. A. Moreira, A. Weber (Freiburg/DE), L. Kolesnikova (Marburg/DE)
Step. Becker (Marburg/DE), H. Bolte, S. Giese (Freiburg/DE), S. Lakdawala (Pittsburgh, PA/US)
M. Beer (Greifswald, Isle of Riems/DE), A. García-Sastre (New York, NY/US)
P92
Role of protein phosphatase 1 (PP1) during Ebola virus transcription
G. Stalmann, Step. Becker, N. Biedenkopf (Marburg/DE)
P93
Tetraspanin CD63 interacts with gp41 – a key molecule for cell-cell transfer of HIV-1
D. Ivanusic, M. Eschricht, J. Denner (Berlin/DE)
p 62
P94
Human norovirus polyprotein expression inhibits cell proliferation, causes membrane
rearrangements and leads to increased caspase activity
S. Doerflinger, V. Lohmann, G. Hansman (Heidelberg/DE)
P95
Hepatitis C virus infection perturbs the lipid profile of the host cell
S. Hofmann (Hamburg/DE), M. Krajewski (Borstel/DE), M. Klabes, M. Melling, P. Truschow
C. Scherer (Hamburg/DE), D. Schwudke (Borstel/DE), E. Herker (Hamburg/DE)
P96
Replication of neuropathogenic and non-neuropathogenic strains of equine herpesvirus 1
(EHV-1) in ED cell line
J. Cymerys, A. Slonska, J. Brzezicka, T. Dzieciatkowski, M. W. Banbura (Warsaw/PL)
P97
Infection and replication efficiency of different human cytomegalovirus glycoprotein O
genotypes
J. Kalser (Vienna/AT), B. Adler, I. Brizic (Munich/DE), H. Vietzen, E. Puchhammer-Stöckl
I. Görzer (Vienna/AT)
P98
Deciphering the RNA Chaperone activity of the West Nile Virus host factor AUF1
S. Friedrich, T. Schmidt, R. P. Golbik, S.-E. Behrens (Halle/Saale/DE)
P99
Determinants of the broad cell tropism of Bungowannah virus – an atypical pestivirus
I. Reimann, M. Richter, M. Beer (Greifswald, Isle of Riems/DE)
P100
Transcomplementational analysis of viral proteins interacting with DDB1
M. Rückborn (Essen/DE), Se. Voigt (Berlin/DE), V. T. K. Le-Trilling, M. Trilling (Essen/DE)
P101
Polycomb repressive complex 2 (PRC2) is important for efficient lytic replication of human
cytomegalovirus
A. Svrlanska, N. Reuter, T. Stamminger (Erlangen/DE)
p 63
P102
Modeling the intracellular replication of influenza A virus in the presence of defective
interfering RNAs
T. Laske, F. S. Heldt, T. Frensing, U. Reichl (Magdeburg/DE)
P103
Monoclonal antibodies against nsp4 of porcine reproductive and respiratory syndrome
virus (PRRSV) show cross-reactivity between genotypes
L. J. Sinn, Be. Lamp, A. Proksch, H.-W. Chen, K. Buczolich, C. Riedel
T. Rümenapf (Vienna/AT)
P104
Influence of three-dimensional cell cultivation on virus infection studies
R. Koban, M. Neumann, O. Bloch, A. Daugs, H. Ellerbrok (Berlin/DE)
P105
Analysis of a Rec-deficient mutant of a reconstituted HERV-K(HML-2)
S. Mostafa, O. Hohn, N. Bannert (Berlin/DE)
P106
Type I interferon antagonistic properties of Influenza B virus polymerase proteins
A. Schreiber, S. Liedmann, D. Anhlan, Y. Börgeling, C. Ehrhardt, S. Ludwig (Münster/DE)
P107
Secondary structure and functional role of the human coronavirus 229E 5‘-terminal
genome region
R. Madhugiri (Giessen/DE), M. Fricke (Jena/DE), N. Karl, D. Petersen (Giessen/DE)
M. Marz (Jena/DE), J. Ziebuhr (Giessen/DE)
P108
Identification of cellular RNA binding proteins that interact preferentially with poorly
spliced influenza virus mRNAs
K. Nilsson, S. Abdurahman, N. Kajitani, S. Schwartz (Lund/SE)
P109
Generation of an avian/mammalian rotavirus reassortant using a helpervirus-dependent
reverse genetics system
E. Trojnar, R. Johne, B. Kaufer (Berlin/DE)
p 64
P110
Semen enhances infection of transmitted/founder and chronic/control HIV-1 strains with
similar efficacy
M. Zou (Guangzhou/CN, Ulm/DE), J. A. Müller, J. Münch (Ulm/DE)
P111
The study of inclusion body fusion mechanism and function of human parainfluenza virus
type 3
She. Zhang, Y. Jiang, Q. Yan, M. Chen (Wuhan/CN)
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p 65
Poster Session 2 • Adaptive Immunity I & II
P112
To the bat MHC! Antigen processing and presentation during viral infection
A. Woon (Clayton/AU), J. Wynne (Geelong/AU), N. Dudek (Clayton/AU)
J. Ng (Singapore/SG), B. Ho (Clayton/AU), M. Baker (Geelong/AU), Lin. Wang (Singapore/SG)
A. Purcell (Clayton/AU)
P113
Activation of Fcγ receptors by hepatitis B virus anti-capsid antibodies
V. Falcone, M. Nassal (Freiburg/DE), E. Corrales-Aguillar (San José/CR)
H. Hengel (Freiburg/DE)
P114
Identification of quantitative binding motifs and Equine Herpesvirus-1-derived CTL
epitopes of equine MHC class I loci
To. Bergmann (Berlin/DE), R. M. Harman, D. M. Miller, D. F. Antczak (Ithaca, NY/US)
J. Sidney, A. Sette (San Diego, CA/US), K. Osterrieder (Berlin/DE; Ithaca, NY/US)
P115
Impact of human IgG1 heavy chain variants on the neutralisation capacity and antibody
dependent cellular cytotoxicity against HCMV
H. Vietzen, E. Puchhammer-Stöckl (Vienna/AT)
P117
Immunisation with immune complexes modulates the fine-specificity of antibody
responses to a flavivirus antigen
G. Tsouchnikas, J. Zlatkovic, J. Jarmer, J. Strauß, O. Vratskikh, M. Kundi, K. Stiasny
F. Heinz (Vienna/AT)
P118
Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions
S. Eickhoff, A. Brewitz (Bonn/DE), M. Y. Gerner (Bethesda, MD/US)
F. Klauschen (Berlin/DE), K. Komander (Bonn/DE), H. Hemmi (Wakayama/JP)
N. Garbi (Bonn/DE), T. Kaisho (Wakayama/JP), R. N. Germain (Bethesda, MD/US)
W. Kastenmüller (Bonn/DE)
P119
Cross-reactivity profiles of CD8+ T cells targeting an immunodominant epitope in the core
protein of HBV
J. Brinkmann (Düsseldorf/DE), H. Kefalakes (Essen/DE), A. Walker (Düsseldorf/DE)
G. Gerken (Essen/DE), J. Timm (Düsseldorf/DE)
p 66
*
* coming soon
Poster Session 2 • Adaptive Immunity I & II
P120
Genetic ablation or pharmacological inhibition of acid sphingomyelinase enhances CD4+
Foxp3+ regulatory T cell activity
C. Hollmann, D. Reuter, N. Müller, S. Werner, E. Avota (Würzburg/DE), L. Japtok
B. Kleuser (Potsdam/DE), K. A. Becker, E. Gulbins (Essen/DE), N. Beyersdorf
J. Schneider-Schaulies (Würzburg/DE)
P121
Induction of TFH-like cells in vitro
A. Kolenbrander (Bochum/DE), K. Überla, V. Temchura (Erlangen/DE)
P122
Molecular footprints within HDV-protein lead to identification of novel CD8 T cell epitopes
H. Karimzadeh (Munich/DE), B. Budeus (Essen/DE), A. Kosinska, T. Bauer (Munich/DE)
A. Heinold, D. Hoffmann (Essen/DE), U. Protzer, M. Roggendorf (Munich/DE)
P123
Identification of novel adenoviral peptide epitopes and their potential in adoptive transfer
immunotherapy
P. Günther, J. Peper, S. Kayser (Tübingen/DE), B. Faist (Munich/DE)
G. Jahn (Tübingen/DE), M. Neuenhahn, D. Busch, T. Feuchtinger (Munich/DE)
S. Stevanović, K. Dennehy (Tübingen/DE)
P124
Specificities of human CD4+ T cell responses to the live attenuated yellow fever virus
vaccine (17D-204)
M. Koblischke, J. Schwaiger (Vienna/AT), M. Mackroth (Hamburg/DE), I. Fae (Vienna/AT)
B. Knapp (Oxford/GB), G. Fischer, K. Stiasny (Vienna/AT), B. Fleischer (Hamburg/DE)
F. X. Heinz, J. H. Aberle (Vienna/AT)
P125
The role of cytotoxic CD4+ T cells in direct protective immunity against retrovirus infection
A. Malyshkina, I. Akhmetzyanova, U. Dittmer (Essen/DE)
p 68
Poster Session 2 • Emerging Viruses
P126
Frequency of astrovirus infection in cattle with non-suppurative encephalitis
S. Selimovic-Hamza, I. Bouzalas, A. Oevermann, L. Truchet, C. Boujon, T. Seuberlich (Bern/CH)
P127
Sequencing of West-African Ebola viruses under outbreak conditions using a novel,
pocket-sized nanopore sequencer
T. Hoenen (Hamilton, MT/US; Greifswald, Isle of Riems/DE)
P128
Detection of the first mesoniviruses in Europe
F. Zirkel, R. Katrin, M. Marklewitz, C. Drosten, S. Junglen (Bonn/DE)
P129
Novel atypical porcine pestivirus (APPV) associated with congenital tremor in newborn piglets
A. Postel, F. Hansmann, C. Bächlein (Hanover/DE), N. Fischer, M. Alawi
A. Grundhoff (Hamburg/DE), S. Derking, J. Tenhündfeld (Vreden/DE), V. M. Pfankuche
V. Herder, W. Baumgärtner, M. Wendt, P. Becher (Hanover/DE)
P130
Characterisation and inhibition of the Chikungunya virus (CHIKV) entry process
C. Weber, L. Henß, K. Sliva, B. Schnierle (Langen/DE)
P131
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in
dromedary camels
B. L. Haagmans, J. M. A. van den Brand, V. S. Raj (Rotterdam/NL), A. Volz (Munich/DE)
P. Wohlsein (Hanover/DE), S. L. Smits, D. Schipper, T. M. Bestebroer
N. Okba (Rotterdam/NL), R. Fux (Munich/DE), A. Bensaid, D. S. Foz (Barcelona/ES)
T. Kuiken (Rotterdam/NL), W. Baumgärtner (Hanover/DE), J. Segalés (Barcelona/ES)
G. Sutter (Munich/DE), A. D. M. Osterhaus (Utrecht/NL)
P132
Hendra virus attachment protein expression in a novel eukaryotic expression system
based on Leishmania tarentolae
K. Fischer, V. Pinho dos Reis, S. Finke (Greifswald, Isle of Riems/DE)
L. Sauerhering (Marburg/DE), E. Stroh, A. Karger (Greifswald, Isle of Riems/DE)
A. Maisner (Marburg/DE), H. Weingartl (Winnipeg/CA), M. H. Groschup, S. Diederich
A. Balkema-Buschmann (Greifswald, Isle of Riems/DE)
p 69
Poster Session 2 • Emerging Viruses
P133
Treatment with hyperimmune equine immunoglobulin or immunoglobulin fragments
completely protects rodents from Ebola virus infection
Xu. Zheng (Changchun/CN), G. Wong (Beijing/CN), Y. Zhao, Hu. Wang (Changchun/CN)
S. He (Winnipeg/CA), Y. Bi (Beijing/CN), W. Chen, H. Jin, W. Gai, D. Chu, Z. Cao
C. Wang (Changchun/CN), Q. Fan (Kunming/CN), H. Chi, Y. Gao, T. Wang, N. Feng, F. Yan
G. Huang, Y. Zheng, N. Li, Yue. Li, J. Qian, Y. Zou (Changchun/CN), G. Kobinger (Winnipeg/CA)
G. F. Gao (Beijing/CN), X. Qiu (Winnipeg/CA), S. Yang, X. Xia (Changchun/CN)
P134
Viral antigen distribution of Variegated Squirrel Bornavirus-1 (VSBV-1) in organs of
naturally infected squirrels
C. Herden, D. Nobach, J. Petzold (Giessen/DE), C. Fast, B. Hoffmann (Greifswald, Isle of Riems/DE)
D. Tappe (Hamburg/DE), D. Höper, J. P. Teifke (Greifswald, Isle of Riems/DE)
J. Schmidt-Chanasit (Hamburg/DE), R. G. Ulrich, M. Beer (Greifswald, Isle of Riems/DE)
P135
Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal
F. Amaro (Águas de Moura/PT), L. Ze-Ze (Águas de Moura, Lisboa/PT)
M. J. Alves (Águas de Moura/PT), J. Börstler, J. Clos, S. Lorenzen (Hamburg/DE)
Stefanie Becker Becker (Hanover/DE), J. Schmidt-Chanasit, D. Cadar (Hamburg/DE)
P136
The glycoprotein Gn/Gc of severe fever with thrombocytopenia syndrome virus is cleaved
by signal peptidase and cleavage is essential for host cell entry
T. Plegge, M. Spiegel, H. Hofmann-Winkler, S. Pöhlmann (Göttingen/DE)
P137
Loss of maternal MERS-CoV antibodies in camel calves triggers virus amplification in
farmed camel herds
B. Meyer, V. M. Corman, M. A. Müller (Bonn/DE), U. Wernery, P. Nagy (Dubai/AE)
C. Drosten (Bonn/DE)
P138
NFkappaB signalling pathway inhibition impairs Puumalavirus propagation
O. Planz, U. Wulle, C. Hartmayer (Tübingen/DE), P. Witkowski, D. Krüger (Berlin/DE)
P140
Characterisation of the non-coding control region of polyomavirus KI isolated from
nasopharyngeal samples from patients with respiratory symptoms or infection and blood
from healthy blood donors in Norway
X. Song, M. Van Ghelue, M. Ludvigsen (Tromsø/NO), S. A. Nordbø (Trondheim/NO)
B. Ehlers (Berlin/DE), U. Moens (Tromsø/NO)
p 70
Poster Session 2 • Trafficking
P141
HCV-induced oxidative stress triggers autophagy via impaired Nrf2 signaling
R. Medvedev, D. Ploen, F. Elgner, H. Ren (Langen/DE)
E. Hildt (Langen, Marburg-Giessen-Lagen/DE)
P142
Molecular characterisation of the interaction between the Lassa virus matrix protein Z and
the cellular motor protein KIF13A
V. Heinecke, A. Meyer, L. Wendt, T. Strecker, S. K. Fehling
P143
Intracellular trafficking of herpes simplex virus type 1 glycoprotein B in syncytial cells
C. Fischer (Münster/DE), M. Vallbracht (Greifswald, Isle of Riems/DE), S. Imdahl
P144
Subcellular trafficking and functional relationship of the HSV-1 Glycoproteins N and M
H. Striebinger (Munich/DE), C. Funk (Stuttgart/DE), V. Raschbichler (Munich/DE)
S. Bailer (Stuttgart, Munich/DE)
Poster Session 2 • Virus Vectors and Gene Therapy
P145
A novel pipeline to produce high-capacity adenoviral vectors for the delivery of the
complete CRISPR machinery exemplified by targeting HPV genomes in cervical cancer
cells
E. Ehrke-Schulz, T. Leitner, S. Dávid, Jin. Liu, M. Schiwon, Th. Bergmann, A. Ehrhardt (Witten/
DE)
P146
DARPins as CAR binding domains
L. Patasic, J. Seifried, I. Schneider, C. Buchholz, C. Tondera, H. Schmitz (Langen/DE)
A. Hombach, H. Abken (Cologne/DE), R. König (Langen/DE; La Jolla, San Diego CA/US)
K. Cichutek (Langen/DE)
p 71
Poster Session 2 • Virus Vectors and Gene Therapy
P147
Layer-by-Layer technology as a supportive tool for virus infection studies
U. Reibetanz, D. Hübner (Leipzig/DE), M. Jung (Halle/Saale/DE), U. G. Liebert
C. Claus (Leipzig/DE)
P148
Inhibition of Ad infection by use of AAV vectors expressing anti-adenoviral artificial
microRNAs
K. Schaar, A. Geisler, M. Kraus (Berlin/DE), C. Röger (Oldenburg/DE)
H. Fechner (Berlin/DE)
P149
Replacement of residual gag sequences by codon-optimised GFP in an HIV-1 vector leads
to rev-independent expression and encapsidation but inhibits infectivity
B. Grewe, B. Tippler (Bochum/DE), J. Bohne (Hanover/DE), R. Wagner
B. Asbach (Regensburg/DE)
Poster Session 2 • Structure and Assembly
P150
Analysing epitope of Dengue virus serotype 1 and 2 as the basis for vaccine development:
A descriptive study of partial envelope (Domain III)
A. Basuki, A. Pramudita, B. E. Dewi (Jakarta/ID)
P151
Influence of Nipah virus matrix protein on viral fusogenicity, particle stability and infectivity
E. Dietzel, M. Weis, L. Kolesnikova, A. Heiner (Marburg/DE), B. Sawatsky
V. von Messling (Langen/DE; Laval/FR), A. Maisner (Marburg/DE)
P152
Transmembrane domains of the tick-borne encephalitis virus E protein in virus assembly
J. Blazevic, F. X. Heinz, K. Stiasny (Vienna/AT)
P153
Processing of GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) type 1:
Efficiency of signal peptide cleavage is affected by glycosylation sites and dimerisation with M
B. Thaa (Stockholm/SE; Berlin/DE), S. A. Neumann, B. Peibst, E. Krause, M. Veit (Berlin/DE)
p 72
P154
African bat henipavirus GH-M74a glycoprotein – Study on the functional importance of N
glycans
L. Behner, K. Wittwer, M. Weis, A. Maisner (Marburg/DE)
P155
Functional characterisation of the N-terminal domain of the pseudorabies virus pUL31
protein
T. Hellberg, P. Gawol, D. Sydow, L. Paßvogel, W. Fuchs, T. Mettenleiter
B. Klupp (Greifswald, Isle of Riems/DE)
P156
Mapping domains of the Schmallenberg virus nonstructural protein NSm
F. Kraatz, K. Wernike, A. Aebischer, I. Reimann, M. Beer (Greifswald, Isle of Riems/DE)
P157
Mutational analysis of the hepatitis B virus S protein oligomerisation
S. Suffner, N. Gerstenberg (Neuherberg/DE)
M. Schindler (Neuherberg, Tübingen, Hamburg/DE), V. Bruss (Neuherberg/DE)
P158
Tubulins interact with S proteins of porcine and human coronaviruses and support
successful assembly and release of infectious viral particles
A.-T. Rüdiger (Hanover/DE), P. Mayrhofer (Munich/DE), I. Speckmann (Hanover/DE)
Y. Ma-Lauer (Munich/DE), G. Pohlentz, J. Müthing (Münster/DE)
A. von Brunn (Munich/DE), C. Schwegmann-Weßels (Hanover/DE)
P159
A C-terminal tetra-lysine motif of the human cytomegalovirus tegument protein pUL71
augments secondary envelopment.
C. Villinger, M. Schauflinger, D. Fischer, P. Walther, T. Mertens, J. von Einem (Ulm/DE)
P160
Mapping and functional characterisation of self-association domains of pUL37 of herpes
simplex virus type 1
W. Hafezi, A. Gossens, N. Kirschnick, J. Kühn (Münster/DE)
p 73
P161
The pUL94/pUL99 complex is a central regulator of human cytomegalovirus virion
assembly
Stefan Becker, C. Villinger, T. Mertens, J. von Einem (Ulm/DE)
P162
Conserved tryptophan motifs in the large tegument protein pUL36 are required for
efficient secondary envelopment of herpes simplex virus capsids
L. Ivanova, A. Buch, K. Döhner, A. Pohlmann, A. Binz, U. Prank, M. Sandbaumhüter
R. Bauerfeind, B. Sodeik (Hanover/DE)
P163
A tyrosine-based trafficking motif of tegument protein pUL71 is crucial for human
cytomegalovirus virion envelopment
A. Dietz, Stefan Becker, J. Keck, C. Villinger, J. von Einem (Ulm/DE)
P164
The herpes simplex virus protein pUL31 escorts nucleocapsids to sites of nuclear egress,
a process coordinated by its N-terminal domain
C. Funk (Stuttgart/DE), M. Ott, V. Raschbichler (Munich/DE), C.-H. Nagel, A. Binz
B. Sodeik, R. Bauerfeind (Hanover/DE), S. Bailer (Stuttgart, Munich/DE)
P165
Crystal structure of the papain-like protease 2 (PLP-2) of human coronavirus NL63
explains unique substrate specificity of the enzyme
A. Lindae, J. Lei, R. Hilgenfeld (Lübeck/DE)
P166
Glutamic acid residues in HIV-1 p6 regulate virus budding and membrane association of gag
M. Friedrich, C. Setz, F. Hahn, A. Matthaei, K. Fraedrich, P. Rauch (Erlangen/DE)
T. Fossen (Bergen/NO), U. Schubert (Erlangen/DE)
P167
Extracellular maturation of secreted hepatitis C virus particles by incorporation of
secreted Apoliporotein E confers enhanced infectivity and partial protection from
neutralizing antibodies
D. Bankwitz, R. Weller, K. Hueging, T. Pietschmann (Hanover/DE)
p 74
P168
MERS-coronavirus papain-like protease is a less efficient enzyme and binds ubiquitin
differently compared to its SARS-CoV counterpart
J. Lei, R. Hilgenfeld (Lübeck/DE)
P169
Probing the main protease of Human Coronavirus NL63 with peptidomimetics reveals
important differences between alpha-and betacoronavirus enzymes
L. Zhang, D. Lin (Lübeck/DE), H. Liu (Shanghai/CN), R. Hilgenfeld (Lübeck/DE; Shanghai/CN)
P170
Macrodomains of MERS Coronavirus
R. Hilgenfeld (Lübeck/DE)
P171
Acylation of human cytomegalovirus pUL99 regulates its function
J. Keck, A.-L. Wild, C. Villinger, J. von Einem (Ulm/DE)
P172
The hepatitis E virus intraviral interactome
A. Osterman (Munich/DE), T. Stellberger (Karlsruhe, Oberschleissheim/DE)
A. Gebhardt, M. Kurz, C. C. Friedel (Munich/DE), P. Uetz (Karlsruhe/DE; Richmond, VA/US)
H. Nitschko (Munich/DE), A. Baiker (Oberschleissheim/DE)
M. G. Vizoso-Pinto (Munich/DE; San Miguel de Tucumán/AR)
Poster Session 2 • Tumor Viruses
P173
Polyomavirus Infections and its clinical relevance in cancer patients – a prospective study
S. Loutfy, M. Moneer (Cairo/EG), S. Salem, E. Abada, E. Ahmed, L. Ibrahim
E.-C. Mohamed (Cairo, Helwan/EG)
P174
MMTV DNA-like env sequences and its association with presence of BRCA1/2 genes
mutations among familial and non-familial Egyptian breast cancer patients
S. Loutfy, Z. Abdullah, M. Shaalan, L. Hegazy, A.-R. Zekri (Cairo/EG)
p 75
Poster Session 2 • Tumor Viruses
P175
Characteristics of Epstein Barr Virus variants associated with gastric carcinoma in
Southern Tunisia
D. Ben Ayed-Guerfali, W. Ayadi, A. Khabir, T. Sallemi-Boudawara
R. Mokdad-Gargouri (Sfax/TN)
P176
The ORF012 gene of Marek’s disease virus type 1 produces a spliced transcript and
encodes a novel nuclear phosphoprotein essential for virus growth
T. Schippers, N. Osterrieder (Berlin/DE)
P177
hnRNP L interacts with HPV16 mRNAs and modulates viral RNA splicing
N. Kajitani, J. Glahder, S. Schwartz (Lund/SE)
P178
SUMO modification of adenovirus E1B-55K oncoprotein required for complete
transformation of primary mammalian cells
V. Kolbe, J. Bezgovsek, J. Berscheminski (Hamburg/DE), S. Schreiner (Munich/DE)
M. H. Tatham, R. T. Hay (Dundee/GB), T. Dobner (Hamburg/DE)
P179
Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate
human hepatoma cell proliferation during HCV infection
Q. Zhang, L. Wei, H. Yang, W. Yang, Q. Yang, Zhu. Zhang, K. Wu, J. Wu (Wuhan/CN)
Poster Session 2 • Antiviral Therapy and Resistance
P180
Immuno-modulating properties of anticancer/antiviral saliphenylhalamide, SNS-032,
obatoclax, and gemcitabine
S. Soderholm, D. Kainov (Helsinki/FI)
P181
Virtual screening and molecular docking for discovering new small molecules against
Ebola VP40 protein
H. Alam El-Din, S. Loutfy (Cairo/EG), S. Kassem (Giza/EG), A. Mayla, M. Elberry
N. Fathy (Cairo/EG), A. Naqvi (Agra/IN)
p 76
P182
Identification and generation of HCMV UL27-mutants with subsequent characterisation in
regard to resistance to antiviral agents
E. Imrich, K. Hamprecht, G. Jahn, K. Göhring (Tübingen/DE)
P183
Aescin as a novel fusion inhibitor against herpes simplex virus type 1 (HSV-1)
D. Ulrich, W. Hafezi, S. Brandt, A. Hensel, J. Kühn (Münster/DE)
P184
LNAs vs. HIV-1 RNA expression – an alternative approach to knock-down viral replication
F. Hillebrand, H. Schaal (Düsseldorf/DE)
P185
Novel procedure to assess resistance relevance of mutations in the thymidine kinase
gene of herpes simplex virus type 1
M. Kaspar, K. Bohn-Wippert, P. Bellstedt, M. Görlach, A. Sauerbrei (Jena/DE)
P186
Coffee inhibits HCV entry and replication in vitro
K. Singethan (Munich/DE), A. D. Keller, A. Wuestenberg, C. Loscher (Hamburg/DE)
A. Herrmann (Munich/DE), V. Lohmann, R. Bartenschlager (Heidelberg/DE), M. Dandri
G. Sass (Hamburg/DE), U. Protzer (Munich/DE), G. Tiegs (Hamburg/DE)
P187
Inhibition of influenza B viruses with neuraminidase inhibitors
S. Duwe, B. Schweiger (Berlin/DE)
P188
Cytosolic phospholipase A2a is a potential drug target for combating infections caused
by plus-strand RNA viruses
C. Müller, M. Hardt, S. Pleschka, J. Ziebuhr (Giessen/DE)
P189
Engineering a modified HsPUM1-HD in order to bind to internal ribosome entry site (IRES)
of hepatitis C virus (HCV)
S. J. Kiani, T. Taheri, M. Maleki, S. Rafati, K. Azadmanesh, S. M. Alavian, T. Mokhtari Azad
K. Samimi-Rad (Tehran/IR)
p 77
P190
Resistance determinants of an orally bioavailable 5-amidino analog of oseltamivir and
their impact on viral fitness – a reverse genetics study in the influenza virus N1
background
A. Hoffmann (Jena/DE), D. Schade (Dortmund/DE), J. Kirchmair (Hamburg/DE)
B. Clement (Kiel/DE), A. Sauerbrei, M. Schmidtke (Jena/DE)
P191
SOCS3 mRNA expression, polymorphisms and response to treatment in HCV genotype
3a infected patients
S. Khaliq, R. Aslam (Lahore/PK)
P192
Cytomegalovirus blocks T cell cytotoxicity by UL36 and UL37x1 and thereby also evades
HLA-independent killing of infected cells by CAR-T cells
J. Proff (Vienna/AT; Erlangen/DE), C. Walterskirchen, C. Brey, R. Geyeregger (Vienna/AT)
F. Full (Erlangen/DE; Chicago, IL/US), A. Ensser (Erlangen/DE), M. Lehner
W. Holter (Vienna/AT)
P193
AAV based heterologous replicon technology for detection and quantification of
adeno-and herpesvirus infections
S. Langer (Munich/DE), V. Kapper-Falcone (Freiburg/DE), H. Nitschko, G. Jäger (Munich/DE)
A. Ehrhardt (Witten/DE), U. Koszinowski (Munich/DE), Z. Ruzsics (Freiburg/DE)
P194
Vitamin D analogs lead to an inhibition of the release of hepatitis B virus in different
genotypes
M. Finkernagel, M. Hassemer, M. Biehl, K. Himmelsbach (Langen/DE), K.-H. Peiffer
C. Lange (Frankfurt a. M./DE), D. Glebe (Marburg, Giessen, Langen/DE), M. Chudy
M. C. Nübling (Langen/DE), E. Hildt (Marburg, Giessen, Langen/DE)
P195
Enrofloxacin, a potent antiviral compound against African swine fever virus in vitro, lacks
detectable antiviral activity in vivo
G. Keil, J. Pietschmann, R. Portugal, S. Blome (Greifswald, Isle of Riems/DE)
P196
Exploitation of PKR as a selector for the identification of immunostimulating influenza
virus RNAs useful for antiviral therapy
M. Budt, F. Jolmes, C. Mache, T. Wolff (Berlin/DE)
p 78
P197
Carboxylic acids of the trail of a slug to fight measles virus
A. R. de Toledo-Piza, C. A. Figueiredo, G. Negri, R. Z. Mendonça (São Paulo/BR)
P198
Tetrahalogenated benzimidazole D-ribonucleoside are active against RCMV in a
2-D as well as 3-D environment
A. Dittmer, I. Woskobojnik (Berlin/DE), J. C. Drach, L. B. Townsend (Ann Arbor, MI/US), Se. Voigt
E. Bogner (Berlin/DE)
P199
HTCC – Broad range inhibitor of coronavirus entry
A. Milewska, K. Pyrc (Krakow/PL)
P200
Development of multiplex qPCR method for cell-culture based testing of antiviral
compounds with potential activity against human adenovirus C
M. Przybylski, T. Dzieciatkowski, R. Zahorska (Warsaw/PL), A. Gorski (Warsaw, Wroclaw/PL)
P201
Antibody-based immunotherapy and prevention of HSV-induced ocular diseases
A. Krawczyk, M. Dirks (Essen/DE), A. Buch (Hanover/DE), M. Alt, U. Dittmer (Essen/DE)
L. Bagnewski, M. Busch, M. Henning (Münster/DE), A.-M. Eis-Hübinger (Bonn/DE)
B. Sodeik (Hanover/DE), A. Heilogenhaus (Münster/DE)
M. Roggendorf (Essen, Munich/DE), D. Bauer (Münster/DE)
P202
KSHV thymidine kinase as a potential target for FDA approved kinase inhibitors
G. Beauclair, J. Rückert, A. Dhingra, N. Samarina, S. Koch
T. F. Schulz (Hanover, Braunschweig/DE)
P203
Hepatitis C virus screening project of patients on current anti-HCV therapy
E. Knops (Cologne/DE), P. Kalaghatgi (Saarbrücken/DE), M. Neumann-Fraune, E. Heger
E. Schuelter (Cologne/DE), T. Lengauer (Saarbrücken/DE), V. Keitel (Düsseldorf/DE)
D. Nierhoff (Cologne/DE), N. Schuebel (Osnabrück/DE), T. von Hahn (Hanover/DE)
I. Peuser (Lüdenscheid/DE), N. Qurishi, K. Römer, S. Scholten (Cologne/DE)
M. Daeumer (Kaiserslautern/DE), J. Schulze zur Wiesch (Hamburg/DE), A. Baumgarten
M. Obermeier, H. Walter (Berlin/DE), R. Kaiser, S. Sierra (Cologne/DE)
p 79
P204
Drug susceptibility of BAC-derived HSV-1 with thymidine kinase variants
A.-K. Brunnemann (Kiel/DE), K. Liermann, S. Deinhardt-Emmer (Jena/DE)
G. Maschkowitz (Kiel/DE), A. Pohlmann, B. Sodeik (Hanover/DE), H. Fickenscher (Kiel/DE)
A. Sauerbrei (Jena/DE), A. Krumbholz (Kiel/DE)
P205
Docosanol and docosanoic acid reduce fusion activity of herpes simplex virus type 1
(HSV-1) glycoproteins
A. Pettke, A. Pogodalla, D. Ulrich, W. Hafezi, J. Kühn (Münster/DE)
P206
Synergistic resistance of group 2 influenza neuraminidase and structural basis of an
oseltamivir-zanamivir hybrid inhibitor
Ya. Wu, F. Gao, J. Qi, M. Pinto, G. F. Gao (Beijing/CN)
P207
Low frequency of the R263K mutation in HIV-1 integrase in patients of the AREVIR cohort
related to raltegravir or elvitegravir therapy failures
N. Lübke (Düsseldorf/DE), E. Knops, E. Heger (Cologne/DE), B. Jensen (Düsseldorf/DE)
T. Kümmerle (Cologne/DE), J. Timm (Düsseldorf/DE), R. Kaiser (Cologne/DE)
P208
A method for the treatment of herpes simplex virus (HSV ½)
C. Spinu, I. Spinu, P. Scoferta, V. Eder, A. Donos (Chisinau/MD)
P209
Structure–activity relationship study of arbidol derivatives as inhibitors of chikungunya
virus replication
R. Filosa, S. Collarile, M. De Rosa (Naples/IT), A. Brancale (Naples/IT; Cardiff/GB), M. Scuotto
C. Schiraldi (Naples/IT)
P210
Features of HIV persistent viremia after the start and restart of antiretroviral treatment
regimens
M. Widera, M. Dirks, R. Jablonka (Essen/DE), M. Däumer (Kaiserslautern/DE)
H. Walter (Berlin/DE), S. Esser, J. Verheyen (Essen/DE)
p 80
P211
Screening an FDA-approved drug library on a cell line that supports the full life cycle of
hepatitis delta virus
L. Nußbaum, F. Lempp, L. Rieble, Y. Ni, S. Urban (Heidelberg/DE)
P212
Broad and potent antiviral activity of the NAE inhibitor MLN4924
V. T. K. Le-Trilling (Essen/DE), D. A. Megger (Bochum/DE), B. Katschinski, C. D. Landsberg
M. U. Rückborn (Essen/DE), S. Tao (Düsseldorf/DE), A. Krawczyk, W. Bayer (Essen/DE)
I. Drexler (Düsseldorf/DE), M. Tenbusch, B. Sitek (Bochum/DE), M. Trilling (Essen/DE)
P213
A humanised neutralising antibody against MERS-CoV targeting the receptor-binding
domain of the spike protein
Yan. Li, G. F. Gao, J. Yan (Beijing/CN)
P214
Novel inhibitors of herpes simplex virus type 1
M. Pachota, K. Pyrć (Krakow/PL)
P215
Antiviral activity of sCAR-Fc against laboratory and clinical strains of coxsackievirus B
serotypes
S. Pinkert (Berlin/DE), M. Schmidtke (Jena/DE), S. Diedrich, H. Zeichhardt, H. Fechner (Berlin/DE)
P216
AAV9 vector-mediated expression of a soluble coxsackievirus-adenovirus receptor
inhibits coxsackievirus B3-induced chronic myocarditis in a therapeutic approach in mice
S. Pinkert, R. Klopfleisch, B. Dieringer (Berlin/DE), M. Schmidtke (Jena/DE), K. Savvatis
H. Fechner (Berlin/DE)
P217
Repurposing of licenced drugs for anti influenza treatment – the clinically approved MEK
inhibitor trametinib efficiently blocks IAV propagation
T. Schräder, S. E. Dudek, A. Schreiber, C. Ehrhardt, S. Ludwig (Münster/DE)
p 81
Poster Session 2 • Evolution of Viruses – Viruses in Evolution
P218
Trends in mosquito infection rates at the rainforest edge – a multitaxa study on the dilution effect hypothesis
M. Marklewitz, A. Kopp, H. Heidemann, K. Hermanns (Bonn/DE), D. Hobelsberger (Berlin/DE)
I. B. Rwego (Kampala/UG, St. Paul, MN/US), A. Estrada (Veracruz/MX), F. H. Leendertz (Berlin/DE)
L. Podsiadlowski (Bonn/DE), T. R. Gillespie (Atlanta, GA/US), C. Drosten, S. Junglen (Bonn/DE)
P219
Genomic characterisation of human parainfluenza viruses types 1 -4 from Vietnam
M. Linster, M. Moorthy (Singapore/SG), N. N. Q. Minh, D. L. A. Ha (Ho Chi Minh City/VN)
Z. Zhe, D. d/o Ravichandran, L. Xing Yi (Singapore/SG), T. A. Tuan,
H. M. Tuan (Ho Chi Minh City/VN), Y. Su (Singapore/SG), H. R. van Doorn (Ho Chi Minh City/VN)
G. J. D. Smith (Singapore/SG)
P220
Inactivation of multiple porcine endogenous retroviruses as a safety measure for
xenotransplantation
J. Denner (Berlin/DE)
P221
Detection of koala retrovirus-B (KoRV-B) in animals in European zoos
U. Fiebig, M. Keller, J. Denner (Berlin/DE)
P222
Virulence of Eurasian H7N7 avian influenza viruses in chickens after acquisition of
different hemagglutinin polybasic proteolytic cleavage site motifs
E.-S. Abdelwhab, J. Veits, T. C. Mettenleiter (Greifswald, Isle of Riems /DE)
P223
Discovery of a novel alphavirus in West Africa
K. Hermanns, F. Zirkel, C. Drosten, S. Junglen (Bonn/DE)
P224
Bovine ephemeral fever virus infection in Turkey
T. C. Oguzoglu, A. Ertürk, Ş. G. Çizmeci (Ankara/TR), B. T. Koç (Aydın/TR), Y. Akca (Ankara/TR)
P225
Impact of altered fidelity of DNA polymerase on herpesvirus genomic variability and
pathogenicity in vivo
J. Trimpert, D. Kunec, N. Osterrieder (Berlin/DE)
p 82
Poster Session 2 • Signal Transduction
P226
The G protein coupled receptor homolog pUS27 of human cytomegalovirus interacts
directly with TRAF6 to induce PAR3-regulated canonical NF-kB activation
I. Niemann, A. Reichel, M. Scherer, S. Mahmoudian, B. Krenz, J. Hofmann, B. Biesinger
H. Sticht, T. Stamminger (Erlangen/DE)
P227
Characterisation of MAPK signalling pathways after rubella virus infection
P. Rennert, H. Geyer, N. Friedrich, A. Mankertz (Berlin/DE)
P228
The mumps virus small hydrophobic protein decreases phosphorylation of p65, IKKβ and
IκBα in the context of a virus infection
St. Franz, N. Friedrich, H. Geyer, A. Mankertz (Berlin/DE)
P229
Measles virus mediated sphingomyelinase activation targets T cell functionality at
multiple levels
E. Avota, L. Collenburg, N. Müller, C. Börtlein, J. Schmitt, A. Schulze
S. Schneider-Schaulies (Würzburg/DE)
P230
Hepatitis C virus (HCV) induces suppressors of cytokine signaling (SOCS) proteins:
Revealing a novel immunomodulatory mechanism
O. Convery, C. O’Farrelly, N. J. Stevenson (Dublin/IR)
Poster Session 3 • Vaccines
P231
Viral determinants of the bias in the HIV-Env specific antibody response
R. Heß (Bochum/DE), M. Storcksdieck (Essen/DE), V. Stab (Bochum/DE)
V. Temchura (Erlangen/DE), M. Tenbusch (Bochum/DE), K. Überla (Erlangen/DE)
P232
Development of vaccination strategies for vector-based prophylactic and therapeutic
immunisation in the Friend retrovirus model
N. Bongard, U. Dittmer, W. Bayer (Essen/DE)
P233
Generation of a broadly-protective AAV-based influenza vaccine
K. Fiddeke, I. Sipo, M. Budt, T. Wolff, N. Bannert, S. Norley (Berlin/DE)
p 83
P234
Steps towards replacing embryonated eggs for poultry vaccine production
I. Jordan, V. Sandig (Berlin/DE)
P235
HBV capsid-derived virus-like particles as a universal antigen carrier for the induction of
robust B-and T-cell responses
S. Akhras, K. Himmelsbach, M. Toda, S. Scheurer, K. Boller, S. Vieths
P236
Protection of poultry with maternally derived α-NDV antibodies against highly pathogenic
avian influenza and Newcastle disease
C. Steglich, C. Grund, T. C. Mettenleiter, A. Römer (Greifswald, Isle of Riems/DE)
P237
Antibody response against the envelope proteins of the feline foamy virus – Mapping of
epitopes and neutralisation
M. Mühle (Berlin/DE), A. Bleiholder, M. Löchelt (Heidelberg/DE), J. Denner (Berlin/DE)
P238
Development of novel double-attenuated live vaccines against H1N1 and H3N2 influenza
virus infection in swine
S. Mamerow, R. Scheffter, T. C. Mettenleiter, J. Stech (Greifswald, Isle of Riems/DE)
P239
Competition of adenovirus epitopes with transgene epitopes – investigation of particular
mechanisms of immonusuppression in adenovirus-based immunisation
C. Hrycak, D. Schöne, U. Dittmer, W. Bayer (Essen/DE)
P240
Identification and characterisation of trimer stabilised HIV envelope proteins
A. Kliche, J. Koop, C. Ziegler, D. Peterhoff, B. Asbach, S. Anja, V. Schmid
R. Wagner (Regensburg/DE)
P241
Identification of novel HIV-1 vaccine candidates using mammalian cell-surface display
and FACS panning
B. Zimmer, V. Grassmann, T.-H. Bruun, T. Schubert, A. Gabele, A. Kliche
p 84
P242
Generation of HIV1 new envelope immunogens with optimised antigenicity profiles
V. Grassmann, M. Glögl, D. Peterhoff, A. Kliche, R. Wagner (Regensburg/DE)
P243
Expression of African swine fever virus proteins by a pseudorabies virus vector
A. Hübner, W. Fuchs, G. Keil, S. Blome, T. C. Mettenleiter (Greifswald, Isle of Riems/DE)
P244
Generation of inactivated influenza virus vaccines using low-energy electron irradiation
J. Fertey, L. Wierich, T. Grunwald (Leipzig/DE), E. Hiller, S. Bailer, S. Rupp (Stuttgart/DE)
A. Pohl, C. Wetzel (Dresden/DE), S. Ulbert (Leipzig/DE)
P245
Influenza A (H7N9) vaccine based on the recombinant measles virus vaccine platform
A. H. Fiedler, B. S. Bodmer, S. Hutzler, S. Vivian, A. L. Walz,, S. Prüfer, V. von Messlin
M. D. Mühlebach (Langen/DE)
P246
Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1
vaccine – a randomised double-blind phase 1/2a clinical trial
J. H. C. Kreijtz, M. Goeijenbier, F. M. Moesker, L. van den Dries, S. Goeijenbier
H. L. M. De Gruyter (Rotterdam/NL), M. H. Lehmann (Munich/DE), G. de Mutsert
D. A. M. van de Vijver (Rotterdam/NL), A. Volz (Munich/DE), R. A. M. Fouchier
E. C. M. van Gorp, G. F. Rimmelzwaan (Rotterdam/NL), G. Sutter (Munich/DE)
A. D. M. Osterhaus (Utrecht/NL)
P247
Myristoylation increases the CD8+ T cell response to a green fluorescent protein
prototype antigen delivered by modified vaccinia virus Ankara
L. Marr, A. Luelf, A. Freudenstein, G. Sutter, A. Volz (Munich/DE)
P248
The analysis of the humoral immune response and the reactivity pattern of monoclonal
antibodies reveal molecular determinants involved in Schmallenberg virus neutralisation
G. Roman-Sosa, K. Wernike, A. Karger (Greifswald/DE), E. Brocchi (Brescia/IT)
H. Schirrmeier (Greifswald/DE), C. Schelp (Bern/CH), M. Beer (Greifswald/DE)
P249
Attenuation of a very virulent Marek’s disease herpes virus by codon pair deoptimisation
K. Eschke, N. Osterrieder, D. Kunec (Berlin/DE)
p 85
P250
Codon pair deoptimisation of a major oncogene as an attenuation strategy for Marek’s
disease herpes virus
P. H. Khedkar, N. Osterrieder, D. Kunec (Berlin/DE)
P251
Licensed adjuvants increase magnitude but not breadth of influenza vaccine-induced
antibody responses
R. Schmidt, R. Wagner, E. Holznagel, T. Enkirch, K. Pfeffermann, B. Sawatsky
V. von Messling (Langen/DE)
P252
Influenza A virus neuraminidase-expressing vesicular stomatitis virus replicons protect
from challenge with matched strains
L. Walz (Langen/DE), G. Zimmer (Mittelhaeusern/CH), V. von Messling (Langen/DE)
P253
Human Cytomegalovirus-based therapeutic vaccine for human Papillomavirus-induced
cancer
M. Abdelaziz, M. Raftery, e. Voigt, A. Kaufmann, G. Schönrich (Berlin/DE)
P254
Generation of a vaccinia virus MVA based vaccine candidate against HCMV
E. Link, C. Brandmüller, S. Ameres, A. Moosmann, G. Sutter, M. H. Lehmann (Munich/DE)
P255
Ex vivo evaluation of Sendaivirus vectors for delivery of CMV IE-1 and pp65
R. Kiener, C. Schwegler (Regensburg/DE), M. Wiegand (Martinsried/DE), B. Asbach
P256
The viral vector vaccine VSV-GP as vaccine platform
J. Kimpel, A. Bresk, R. Tober, M. Krismer, S. Schneider, T. Hofer (Innsbruck/AT)
T. Grunwald (Leipzig/DE), H.-X. Liao, B. Haynes (Durham, NC/US), Z. Banki, L. Egerer
D. von Laer (Innsbruck/AT)
p 86
Poster Session 3 • Viral Pathogenesis and Persistence
P257
tRNA retrograde transport in nuclear import of HIV-1
G. Adigbli, A. Fassati (London/GB)
P258
A single amino acid change in the Marburg virus matrix protein VP40 provides a
replicative advantage in a species-specific manner
A. Köhler, L. Kolesnikova, U. Welzel, G. Schudt, A. Herwig, Step. Becker (Marburg/DE)
P259
Old World Hantaviruses cause functional impairment in human podocytes
S. Hägele (Heidelberg/DE), J. Reiser (Chicago, IL/US), M. Zeier, E. Krautkrämer (Heidelberg/DE)
P260
Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased
foam cell formation after transendothelial migration
A. Maisa (Münster/DE; Melbourne/AU), A. C. Hearps, T. A. Angelovich, C. F. Pereira
J. Zhou, M. D. Y. Shi, C. S. Palmer (Melbourne/AU), W. A. Muller (Chicago, IL/US)
S. M. Crowe, A. Jaworowski (Melbourne/AU)
P261
Highly sensitive PCR diagnostic systems revealed porcine cytomegalovirus (PCMV) in the
blood of Göttingen minipigs to be used as donors of islet cells
V. Morozov, J. Denner (Berlin/DE)
P262
Establishment of a suitable cell line model for the investigation of Na,K-ATPase
de-localisation during influenza A virus infection
I. Kuznetsova, C. Peteranderl, S. Herold (Giessen/DE), T. Wolff (Berlin/DE)
P263
Conserved death-receptor signaling inhibition identified by a chimeric mouse CMV
expressing a homologous human CMV gene
M. Z. Chaudhry, B. Kasmapour, M. Bajagic, R. Casalegno, L. Borkner (Braunschweig/DE)
T. Lenac (Rijeka/HR), A. Scrima, A. Scrima (Braunschweig/DE), S. Jonjic (Rijeka/HR)
L. Cicin-Sain (Braunschweig/DE)
P264
Rat brain organotypic slice culture as a model for studying measles virus neurotropism
S. Chey, U. G. Liebert, Jo. Busch (Leipzig/DE)
p 87
P265
Binding of the immunosuppressive domain of the transmembrane envelope protein gp41
of HIV-1 to human monocytes and B cells
M. Mühle, T. Kroniger, K. Hoffmann, J. Denner (Berlin/DE)
P266
Strain-specific cytopathogenicity of rubella virus appears to be related to viral impact on
mitochondrial metabolism
C. Claus, S. Rossmark, U. G. Liebert (Leipzig/DE)
P267
Directed knockdown of cellular genes by rabies virus expressing shRNAs
S. Nemitz, T. Nolden, S. Finke (Greifswald, Isle of Riems/DE)
P268
Annotating the HSV-1 proteome by ribosome profiling and quantitative proteomics
F. Erhard (Munich/DE), A. Rutkowski (Cambridge/GB), E. Wyler (Berlin/DE), H. Ayoubian
J. Menegatti (Homburg/DE), A. L’Hernault (Cambridge/GB), M. Landthaler (Berlin/DE)
C. Friedel, R. Zimmer (Munich/DE), F. Grässer (Homburg/DE), L. Dölken (Würzburg/DE)
P269
The Newcastle disease virus W protein – an editing product of the phosphoprotein
J. Karsunke, A. Karger, K. Franzke, M. Murr, T. C. Mettenleiter
A. Römer-Oberdörfer (Greifswald, Isle of Riems/DE)
P271
Experimental infection of horses with nonprimate hepacivirus mediates immune
protection against re-infection
S. Walter, S. Pfaender, D. Todt, E. Grabski, T. Gather, S. Möller, R. J. P. Brown, A. Postel
K. Hahn, C. Puff, V. Pfankuche, F. Hansmann, P. Becher, U. Kalinke, W. Baumgärtner
K. Feige, T. Pietschmann, J.-M. V. Cavalleri, E. Steinmann (Hanover/DE)
P272
The phosphoprotein of Borna disease virus impairs human GABAergic neurogenesis
C. Scordel (Munich/DE), A. Huttin, M. Cochet-Bernoin (Maisons-Alfort/FR)
M. Szelechowski (Toulouse/FR), A. Poulet (Evry/FR), J. Richardson (Maisons-Alfort/FR)
A. Benchoua (Evry/FR), D. Gonzalez-Dunia (Toulouse/FR), M. Eloit (Paris/FR)
M. Coulpier (Maisons-Alfort/FR)
p 88
P273
Avian nephritis virus is related with the runting-stunting syndrome in Brazil
L. Nunez, S. Santander-Parra, D. De la Torre, C. Carranza, C. Astolfi-Ferreira
A. Ferreira (Sao Paulo/BR)
P274
Infection of porcine intestinal slices by different transmissible gastroenteritis virus strains
T. Krimmling, A. Beineke, C. Schwegmann-Weßels (Hanover/DE)
P275
Characterisation of feline coronavirus 7b accessory protein
D. Florek, J. Ziebuhr, H.-J. Thiel, G. Tekes (Giessen/DE)
P276
High prevalence of adeno-associated virus (AAV) in human peripheral blood mononuclear
cells indicative of T-lymphocytes as sites of AAV persistence
D. Khalid, D. Hüser, T. Lutter, M. Heßler, U. Kalus, Y. Tauchmann, K. Hensel-Wiegel
D. Lassner, R. Heilbronn (Berlin/DE)
P277
Generation and characterisation of the first molecular clone of deformed wing virus
(DWV) – a major factor in honeybee colony collapse
Be. Lamp, L. Sinn, K. Buczolich, H.-W. Chen, T. Rümenapf (Vienna/AT)
P278
Mutations in measles virus fusion and matrix protein alter replication as well as
cytopathology in cultured cells and promote infection of neuronal cells
Jo. Busch, S. Chey, U. G. Liebert (Leipzig/DE)
P279
Investigation of virus infection-related congenital disorders and miscarriage events
through induced pluripotent stem cells
D. Hübner (Leipzig/DE), M. Jung (Halle/Saale/DE), U. G. Liebert, C. Claus (Leipzig/DE)
P280
Successful generation of human peripheral neurons to study varicella zoster virus
S. Zhu, B. Ritter, N. Stanslowsky (Hanover /DE), B. Kaufer, K. Osterrieder (Berlin/DE)
G. M. G. Verjans (Rotterdam/NL; Hanover/DE), A. Leffler, F. Wegner
A. Viejo-Borbolla (Hanover/DE)
p 89
P281
Genetic contribution of H7N9 virus to the virulence in mice
Y. Bi, G. Wong, Shu. Zhang, Yun Li, Ya. Wu, L. Fu, J. Haywood (Beijing/CN), Hai. Xiao (Tianjin/CN)
Ju. Liu (Beijing/CN), Yingx. Liu (Shenzhen/CN), W. Liu (Beijing/CN)
G. F. Gao (Beijing, Shenzhen/CN)
P282
In vitro evolution of persistent rabies virus
A. Ghanem, M. F. Eizinger, K.-K. Conzelmann (Munich/DE)
P283
Animal model for Ebola virus research in BLS 2 lab
X. Zhao, X. Qu, Wei Zhang, X. Zhou, G. F. Gao (Beijing/CN)
P284
Proteasome inhibition alters cell viability and inhibits Cowpox virus replication
M. Grossegesse, A. Fritsch, J. Döllinger, A. Nitsche (Berlin/DE)
P285
Cholestasis in mice reduces anticytomegaloviral immune responses
A.-K. Schupp, S. Rattay, A. Kislat, B. Homey, D. Häussinger, D. Graf
A. Zimmermann (Düsseldorf/DE)
P286
Alveolar macrophages are infected and depleted during pneumovirus infection in vivo
L. Prager, C. D. Krempl (Würzburg/DE)
P287
Dengue serotype determined by neutralisation and anti-ED3 responses is not correlated
to the Dengue serotype present in acute infection
H. Auerswald, L. Klepsch (Hamburg/DE), V. Duong, B. Y, P. Buchy
P. Dussart (Phnom Penh/KH), M. Schreiber (Hamburg/DE)
P288
Characterisation of Cowpox virus proteins based on protein interaction studies
I. Schlenther, L. Schrick, J. Döllinger, A. Nitsche (Berlin/DE)
P289
The secreted Pestiviral ribonuclease Erns forms high molecular weight complexes
reminiscent of Dengue virus NS1
T. Ruemenapf, Be. Lamp (Vienna/AT), T. Krey (Hanover/DE), M. Schweizer (Bern/CH)
B. Raynal (Paris/FR), B.-J. Bosch (Utrecht/NL), D. Veesler (Seattle, WA/US)
p 90
Poster Session 3 • Host Cell Factors and Modulation I & II
P290
Marburg virus VP30 counteracts the induction of the unfolded protein response
C. Rohde, Step. Becker, V. Krähling (Marburg/DE)
P291
L-Particles transmit viral proteins from HSV-1-infected mDC to uninfected bystander cells
inducing CD83 downmodulation
C. Heilingloh, M. Kummer, P. Mühl-Zürbes, C. Draßner, C. Daniel, M. Klewer
A. Steinkasserer (Erlangen/DE)
P292
Modulation of dendritic cell adhesion and migration by herpes simplex virus type 1 and
human cytomegalovirus
L. Grosche, C. Draßner, A. Steinkasserer, C. S. Heilingloh (Erlangen/DE)
P293
Annexin A8 and its diverse function during influenza A virus infection
S. Schloer, V. Gerke, C. Ehrhardt, S. Ludwig, U. Rescher (Münster/DE)
P294
Mammalian haploid genetic screen to identify host factors essential for Rift Valley fever
virus
S. Devignot (Giessen/DE), A. Leibbrandt, T. Burkard, J. Penninger (Vienna/AT)
F. Weber (Giessen/DE)
P295
Development of arenavirus lifecycle modelling systems for screening of host cells factors
involved in virus replication
E. Dunham, K. Shifflett, A. Watt, H. Feldmann (Hamilton, MT/US), T. Hoenen
A. Groseth (Greifswald, Isle of Riems/DE; Hamilton, MT/US)
P296
Protein signatures of permissive vs. non-permissive influenza A virus infections in human
host cells identified by quantitative proteomics
A. Sadewasser, K. Paki, K. Eichelbaum, B. Bogdanow, A. Karlas, M. Lesch, M. Selbach
T. Wolff (Berlin/DE)
P297
Genetic variations in Cytokine genes (IL10 and IL6) and toll like receptors (TLRs 3, 4, 7 and
8) in patients with DF and DHF
S. Khaliq, M. Raza (Lahore/PK)
p 91
P298
First demonstration of a kinase activity-dependent interaction between the herpesviral
CDK ortholog pUL97 and human cyclin B1
M. Steingruber, E. Socher, H. Sticht (Erlangen/DE), Y. Couté, A. Kraut (Grenoble/FR)
C. Hutterer, M. Marschall (Erlangen/DE)
P299
Peptidyl-prolyl isomerase Pin1 is an important effector in the phosphorylation-triggered
reorganisation of the nuclear lamina during herpesvirus nuclear egress
J. Milbradt, C. Hutterer, H. Bahsi, S. Wagner, A. C. Horn (Erlangen/DE)
B. B. Kaufer (Berlin/DE), Y. Mori (Kobe/DE), H. Sticht (Erlangen/DE), T. Fossen (Bergen/DE)
M. Marschall (Erlangen/DE)
P300
IFN treatment induces post-transcriptional regulation of SAMHD1 mRNA by regulation of
miR-181a and miR-30a
M. Rieß, N. V. Fuchs (Langen/DE), A. Idica, M. Hamdorf (Irvine, CA/US), H. Schmitz
C. Tondera, K. Cichutek, E. Flory (Langen/DE), I. Munk Pedersen (Irvine, CA/US)
R. König (Langen/DE; La Jolla, San Diego, CA/US)
P301
Establishment of a HEV replication system for screening of substances interfering with
hepatitis E virus replication
K. Funke (Langen/DE), E. Hildt (Giessen, Marburg, Langen/DE)
K. Himmelsbach (Langen/DE)
P302
The autophagosomal SNARE protein syntaxin 17 is an essential factor for the hepatitis C
virus life cycle
H. Ren, F. Elgner, B. Jiang, K. Himmelsbach, R. Medvedev, D. Ploen, E. Hildt (Langen/DE)
P303
Mechanism of Selective Autophagy of NEMO by Murine Cytomegalovirus M45
E. Muscolino, R. Brost, E. Krause (Hamburg/DE), S. Loroch (Dortmund/DE), A. Gallo
W. Brune (Hamburg/DE)
P304
Nrf2 activation in HBV replicating cells and its effect on T cell-mediated immune response
M. Biehl (Langen/DE), K. Wisskirchen, U. Protzer (Munich/DE), E. Hildt (Langen/DE)
p 92
P305
Herpes simplex virus 1 infection leads to widespread induction of antisense transcripts
on the host cell genome
E. Wyler, V. Franke (Berlin/DE), J. Menegatti (Homburg/DE), A. Boltengagen, L. Münster
A. Akalin, N. Rajewsky, C. Kocks (Berlin/DE), F. Grässer (Homburg/DE), M. Landthaler (Berlin/DE)
P306
The mouse cytomegalovirus encoded adapter protein m42 targets the receptor tyrosine
phosphatase CD45 for lysosomal degradation in myeloid cells affecting viral pathogenesis
N. Thiel, K. Keyser (Hanover/DE), I. Dekhtiarenko (Braunschweig/DE), C. Zimmermann
A. Halenius (Freiburg/DE), N. Lemmermann (Mainz/DE), L. Cicin-Sain (Braunschweig/DE)
M. Messerle (Hanover/DE)
P307
Perilipin-2 regulates lipid droplet morphology and hepatitis C virus replication
S. Lassen, C. Grüttner, E. Herker (Hamburg/DE)
P308
FG repeats are general binding motifs of nuclear pore proteins to the HIV-1 capsid
T. Fricke (New York, NY/US; Warsaw/PL), F. Di Nunzio (Paris/FR)
F. Diaz-Griffero (New York, NY/US)
P309
Expression of IL-1β mRNA in primary murine neurons infected with different strains of
equine herpesvirus type 1 (EHV-1)
A. Golke, J. Cymerys, T. Dzieciatkowski, A. Chmielewska, A. Tucholska, A. Slonska
M. W. Banbura (Warsaw/PL)
P310
Rift Valley fever virus NSs virulence factor blocks the nuclear export of host mRNAs
S. Lau (Marburg, Giessen/DE), M. Habjan (Martinsried, Munich/DE), G. Superti-Furga (Vienna/AT)
A. Pichlmair (Martinsried, Munich/DE), M. Kainulainen (Marburg/DE), F. Weber (Marburg, Giessen/DE)
P311
The MCMV tegument protein M25 is targeted to PLM bodies by sumoylated host proteins
I. Kutle, M. Dezeljin, K. Keyser, R. Niedenthal, M. Messerle (Hanover/DE)
P312
Comparative identification of cellular interaction factors of the PB2 proteins of H5N1 and
H3N2 influenza A viruses in human cells by mass spectrometry
U. Arnold, T. Wolff (Berlin/DE)
p 93
P313
Role of caspase-2 during human cytomegalovirus infection
J. Tang, E. Ostermann (Hamburg/DE), R. J. Lebbink (Utrecht/NL), W. Brune (Hamburg/DE)
P314
Herpes simplex virus 1 VP1-2 tegument protein interferes with the DNA damage response
T. Hennig (Würzburg/DE; London/GB), R. Serwa (London/GB), L. Dölken (Würzburg/DE)
P. O‘Hare (London/GB)
P315
HIV-1 gene expression is not inhibited by type-1 interferon responses in the absence of
accessory genes
Han. Xiao (Erlangen/DE), L. Legewie, B. Grewe (Bochum/DE), K. Überla (Erlangen/DE)
P316
Restrictive influence of SAMHD1 on hepatitis B virus life cycle
A. Sommer, L. Rivière, K. Schott (Langen/DE), Y. Ni (Heidelberg/DE), M. Rieß, E. Schnellbächer
N. Kettern (Langen/DE), C. Münk (Düsseldorf/DE), C. Donnerhak, E. Flory (Langen/DE)
S. Urban (Heidelberg/DE), E. Hildt (Langen/DE), R. König (La Jolla, San Diego, CA/US; Langen/DE)
P317
Analysis of host factors in measles virus replication
V. Tiwarekar, J. Wohlfahrt, S. Kendl, M. Fehrholz, J. Schneider-Schaulies (Würzburg/DE)
P318
T-cells expressing reduced restriction factors are preferentially HIV-1 infected in vivo
S. Bolduan, H. Koppensteiner, R. Brack-Werner, R. Draenert (Munich/DE)
M. Schindler (Tübingen, Munich/DE)
P319
Identification and characterisation of cellular interaction partners of Schmallenberg virus NSs
A. Aebischer, F. Kraatz, K. Wernike, I. Reimann, M. Beer (Greifswald, Isle of Riems/DE)
P320
Interactions of prototype foamy virus capsids with host cell polo-like kinases are
important for efficient virus entry
I. Zurnic, S. Hütter, N. Stanke, R. Helbig, U. Lehmann, G. Gerresheim, F. Lindel
D. Lindemann (Dresden/DE)
p 94
P321
Identification of macrophage host range factors of Cowpox virus
D. Bourquain, J. Yeonhwa, A. Nitsche (Berlin/DE)
P322
Preliminary comparison of differentially expressed ncRNAs in bat and human cells
infected with Ebola Zaire virus and Marburg virus
N. F. Mostajo Berrospi (Jena, Marburg/DE), M. Hoelzer (Jena/DE), Step. Becker (Marburg/DE)
M. Marz (Jena/DE)
P323
Virulence factor NSs of La Crosse virus sequesters Elongin C – a possible mechanism for
inducing degradation of the largest subunit of RNA polymerase II
A. Schoen (Marburg/DE), P. Verbruggen (Freiburg/DE), F. Weber (Giessen/DE)
P324
ESCRT requirements for Murine Leukemia virus release
C. Bartusch, R. Prange (Mainz/DE)
P325
Non-pathogenic Tacaribe virus and human pathogenic Junín virus differ in apoptosis
induction during infection
S. Wolff (Marburg/DE), A. Groseth (Greifswald, Isle of Riems/DE)
B. Meyer (Twin Cities, MN/US), D. Jackson (St. Andrews/GB), T. Strecker, A. Kaufmann
Step. Becker (Marburg/DE)
P326
Mutational analysis of the MCMV-encoded interferon antagonist dissects pM27
interactions with DDB1 and STAT2
V. T. K. Le-Trilling, T. Becker, C. Landsberg, M. Trilling (Essen/DE)
P327
Merkel cell polyomavirus (MCPyV) replication is negatively regulated by the host
restriction factor Kap1/TRIM28
S. Siebels, M. Czech-Sioli, C. Schmidt, F. Neumann, A. Grundhoff, N. Fischer (Hamburg/DE)
P328
DNA damage-binding protein 1 promotes transcription from covalently closed circular
DNA in hepatitis B virus infection
B. Qu (Heidelberg/DE), J. Sonnabend (Frankfurt a. M./DE), P. Hezel (Nuremberg/DE)
S. Urban (Heidelberg/DE)
p 95
P329
Cholesterol and related host factors in influenza A virus infection
A. Kühnl, A. Musiol, C. Ehrhardt, S. Ludwig (Münster/DE), T. Grewal (Sydney/AU), V. Gerke
U. Rescher (Münster/DE)
P330
Interaction of matrix proteins with nuclear ANP32B is conserved among Henipa-and
Avulaviruses
M. Günther, A. Bauer, L. Zaeck, A. Römer-Oberdörfer, S. Finke (Greifswald, Isle of Riems/DE)
P331
Discovery of a novel chemokine binding activity in varicella zoster virus
V. Gonzalez-Motos, B. Ritter (Hanover/DE), T. Lenac, S. Jonjic (Rijeka/HR), U. Kalinke
A. Viejo-Borbolla (Hanover/DE)
P332
Regulation of cell death upon influenza A virus and Staphylococcus aureus super-infection
A. van Krüchten, C. Klemm (Münster/DE), B. Löffler (Jena/DE), S. Niemann, G. Peters
S. Ludwig, C. Ehrhardt (Münster/DE)
P333
The SAMHD1-mediated inhibition of LINE-1 retroelements is regulated by phosphorylation
A. Herrmann, S. Wittmann (Erlangen/DE), N. Gilbert (Montpellier/FR), C. Shepard (Atlanta, GA/US)
D. Thomas, N. F. Bouzas (Frankfurt/DE), B. Kim (Atlanta, GA/US), T. Gramberg (Erlangen/DE)
P334
Herpes simplex virus type 1 infection in brain cells leads to an up-regulation of
neurotrophic fibroblast growth factors
V. Lübben, B. Förthmann, N. Hensel, A. Buch, M. Ciurkiewicz, A. Beineke, B. Sodeik
P. Claus (Hanover/DE)
P335
Screening for IFN signaling antagonists – Stathmin-1 as a potential cellular regulator?
M. Maywald (Düsseldorf/DE), H. Hengel (Freiburg/DE), A. Zimmermann (Düsseldorf/DE)
P336
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity
S. Wittmann (Erlangen/DE), R. Behrendt (Dresden/DE), K. Eissmann
B. Volkmann (Erlangen/DE), D. Thomas (Frankfurt/DE), T. Ebert, V. Hornung (Bonn/DE)
A. Cribier, M. Benkirane (Montpellier/FR), N. Ferreirós Bouzas (Frankfurt/DE)
p 96
P337
Virus supportive function of the macroautophagy-related proteins Beclin1 and Atg7
during influenza A virus infection
S. Dudek, S. Ludwig (Münster/DE)
P338
A bifunctional element in β-herpesviral kinases mediates cross-regulation with cyclin A
and inhibition of cellular DNA synthesis
M. Schmidt, H. Weisbach, I. Gruska, B. Vetter, B. Bogdanow, K. Imami, M. Selbach
C. Hagemeier, L. Wiebusch (Berlin/DE)
Poster Session 3 • Epidemiology and Public Health
P339
Scanning surveillance of neuroinfectious viruses in cattle livestock
L. Truchet, J. Walland, C. Boujon, S. Selimovic-Hamza, H. Posthaus, G. Schüpbach
A. Oevermann, T. Seuberlich (Bern/CH)
P340
Molecular detection and prevalence of viruses in wild boar population of eastern Saxony:
Potential risks for transmission to domestic pigs and humans
A. Muluneh, S. Jäckel (Dresden/DE)
P341
Proportion of recent HIV-1 Subtype A infections is increasing in Germany (2013 to 2015/I)
A. Hauser, A. Hofmann, K. Hanke, V. Bremer, B. Bartmeyer, C. Kuecherer
N. Bannert (Berlin/DE)
P342
High proportion of HIV-1 non-B subtypes in lately diagnosed HIV-patients
S. Girra, A. E. Alemayehu, A. Hoffmann, V. Bremer, B. Bartmeyer, C. Kuecherer, N. Bannert
A. Hauser (Berlin/DE)
P343
High prevalence of human papillomaviruses in Ghanaian pregnant women
S. Silling, H. Pfister (Cologne/DE), F. Völker, R. Lugert (Göttingen/DE)
P. Cooper (Eikwe via Axim/GH), U. Groß, M. Schulze (Göttingen/DE)
p 97
Poster Session 3 • Zoonoses
P344
A varicella-zoster virus-like herpes virus in a great ape species – The first genomic
sequence of a varicella virus infecting gorillas
J. Kühn, C. Ludwig (Münster/DE), S. Calvignac-Spencer, B. Ehlers (Berlin/DE)
P345
Detection of porcine cytomegalovirus (PCMV) in a baboon after transplantation of a pig
heart
V. A. Morozov (Berlin/DE), J.-M. Abicht, B. Reichart, T. Mayr, S. Guethoff (Munich/DE)
J. Denner (Berlin/DE)
P346
Immunogenicity and protective efficacy of recombinant modified vaccinia virus Ankara
candidate vaccines delivering West Nile virus envelope antigens
A. Volz (Munich/DE), S. Lim (Utrecht/NL), M. Kaserer, A. Luelf, L. Marr, S. Jany
C. Deeg (Munich/DE), G. Pijlmann (Wageningen/NL), A. D. M. Osterhaus
B. Martina (Utrecht/NL), G. Sutter (Munich/DE)
P347
Phylogenetic analysis of novel strains of Puumala hantavirus associated with its reservoir
rodent host, bank vole (Myodes glareolus), in Central Europe
R. Szabó (Bratislava/SK), L. Radosa (Berlin/DE), M. Ličková, M. Sláviková (Bratislava/SK)
M. Heroldová (Brno/CZ), M. Stanko (Košice/SK), M. Pejčoch (Prague/CZ)
D. H. Kruger (Berlin/DE), S. Essbauer (Munich/DE), B. Klempa (Bratislava/SK, Berlin/DE)
Poster Session 3 • Clinical Virology
P348
Primary vs secondary HCMV infection in pregnancy and outcome in the newborn
G. Jahn (Tübingen/DE), L. Ye, J. Xu (Shanghai/CN)
P349
Correlation of chikungunya viral load with observed clinical features
B. Siva Raghavendhar, P. Ray (New Delhi/IN)
P350
Identification of coxsackievirus A6 in adult patients with hand foot and mouth disease
A. Osterman, L. Jakob, H. Nitschko, G. Jäger (Munich/DE)
p 98
P351
Chronic persistent parvovirus B19 bone marrow infection resulting in
transfusion-dependent pure red cell aplasia in multiple myeloma after allogeneic
hematopoietic stem cell transplantation and severe graft versus host disease
M. Karrasch (Jena/DE), V. Schmidt (Jena, Erfurt/DE), A. Hammer, B. Hermann
A. Sauerbrei (Jena/DE)
P352
Transmission of a ganciclovir resistant CMV variant from a pregnant renal transplant
patient to her child
J. Korth, O. Witzke, J. Verheyen (Essen/DE)
P353
A rare case of severe enterovirus 71-induced rhombencephalitis and acute heart failure
following hand, foot, and mouth disease
M. Karrasch, E. Fischer, M. Scholten, A. Sauerbrei, A. Henke, D. Renz
H.-J. Mentzel (Jena/DE), A. Krumbholz (Jena, Kiel/DE), S. Böttcher (Berlin/DE)
S. Diedrich (Berlin/DE), R. Zell (Jena/DE)
P354
Next generation sequencing of human cytomegalovirus genomes from sequentially
sampled immunocompromised patients suggests turnover of viral strains
E. Hage (Hanover/DE), G. S. Wilkie (Glasgow/GB), S. Linnenweber-Held, A. Dhingra
E. Mischak-Weissinger, A. Schwarz, A. Heim (Hanover/DE), A. J. Davison (Glasgow/GB)
T. F. Schulz, T. Ganzenmueller (Hanover/DE)
P355
Clinical outcome and HBsAg variability of hepatitis B virus induced acute liver failure
O. E. Anastasiou, M. Widera, A. Canbay, J. Verheyen (Essen/DE)
P356
Isolation and characterisation of aviadenoviruses from commercial poultry in Germany
D. Lüschow, A. Kleine, H. M. Hafez (Berlin/DE)
P357
Prevalence and type of human parechovirus in stool samples from Ghanaian children
S. Graul (Freiburg/DE), D. Eibach, R. Krumkamp, J. Käsmaier (Hamburg/DE)
Y. Adu-Sarkodie (Kumasi/GH), J. May, E. Tannich (Hamburg/DE), M. Panning (Freiburg/DE)
P358
Detection of BK virus in patients after kidney transplantation
J. Korth, M. Widera, O. Witzke, J. Verheyen (Essen/DE)
p 99
P359
Rusa alfredi papillomavirus 1 – a novel deltapapillomavirus inducing endemic
papillomatosis in the endangered Visayan spotted deer
R. Fux, M. C. Langenmayer (Munich/DE), D. Jörgens, C. Schubert
J.-O. Heckel (Landau i. d. Pfalz/DE), G. Sutter (Munich/DE)
P360
Influence of different blood collection tubes on virus diagnostics
J. Klenner, C. Kohl, A. Nitsche (Berlin/DE)
P361
Human polyomavirus JC and BK serum antibody response in patients with progressive
multifocal leucoencephalopathy
O. Adams, M. Andree, C. Warnke (Düsseldorf/DE)
P362
Routine sequencing of enteroviruses in clinical materials identifies “new” group
C-enterovirus types in the Netherlands
C. Van Leer-Buter, R. Poelman, R. Borger, B. Niesters (Groningen/NL)
P363
An unusual course of parvovirus B19 infection
U. Reber, S. Aldabbagh, S. Pietzonka, O. Moser, A. Simon (Bonn, Homburg/Saar/DE)
A. Eis-Hübinger (Bonn/DE)
P364
Evidence of human herpesvirus-6 and -7 reactivation in miscarrying women with
pityriasis rosea
F. Drago, G. Ciccarese, F. Broccolo, F. Drago, A. Parodi (Genoa/IT)
P365
Encephalitis caused by a novel human adenovirus type of species D in an adult allogeneic
haematopoietic stem cell transplant recipient
E. Hage (Hanover/DE), A. Turki (Essen/DE), T. Ganzenmüller (Hanover/DE), R. Trenschel
S. Ross (Essen/DE), A. Heim (Hanover/DE)
P366
Macromolecular prodrugs of HDACi, panobinostat, against HIV latency
K. Zuwala, A. A. A. Smith, M. Tolstrup, A. N. Zelikin (Aarhus/DK)
p 100
Did you
Know?
Conventus is the professional
Congress Organiser for the GfV 2016*
*Gesellschaft für Virologie e. V.
Sponsors
We would like to give our sincere thanks to the following sponsors:
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p 102
Media Cooperations and Scientific Sponsors
We would like to thank the following media partners and scientific sponsors for their great support:
Media Cooperations
Springer-Verlag GmbH (Vienna/AT)
Archives of Virology
European Journal of Clinical Microbiology & Infectious Diseases
Virus Genes
succidia AG (Darmstadt/DE)
labor&more
TRILLIUM GmbH (Grafrath/DE)
Trillium Diagnostik
Scientific Sponsors
Cluster of Excellence „Cells in Motion“ (CiM)
Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V. (DVV, German Association for the Control of Virus Diseases)
Gesellschaft für Virologie e. V. (GfV, Society for Virology)
Münster Graduate School of Evolution (MGSE) German Research Platform for Zoonoses (Berlin/DE)
University of Münster (WWU)
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p 103
Industrial Exhibition
2nd Floor
Entrance
5
15
27
7
6
13
17
14
16
26
8
12
18
9
11
10
19
25 24 23 22
21
20
Ground Floor
30
29
28
4
3
2
1
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p 104
Exhibitors (in alphabetical order) • Vom-Stein-Haus – Schlossplatz 34
The following exhibitors are looking forward to welcoming you at their booth:
Exhibitors
Abbot GmbH & Co. KG (Wiesbaden/DE)
Acris Antibodies GmbH (Herford/DE)
altona Diagnostics GmbH (Hamburg/DE)
Analytik Jena AG (Jena/DE)
Beckman Coulter GmbH (Krefeld/DE)
Becton Dickinson GmbH (Heidelberg/DE)
Biocartis NV (Mechelen/BE)
Biomol GmbH (Hamburg/DE)
BIO-SYS GmbH (Karben/DE)
Biozol Diagnostica Vertrieb GmbH (Eching/DE)/BioLegend (San Diego, CA/US)
Biozym Scientific GmbH (Hessisch Oldendorf/DE)
Cepheid GmbH (Frankfurt a. M./DE)
GATC Biotech AG (Konstanz/DE)
German Research Platform for Zoonoses (Berlin/DE)
German Society for Immunology – DGfI (Berlin/DE)
Greiner Bio-One GmbH (Leipzig/DE)
Hologic Deutschland GmbH (Wiesbaden/DE)
Implen GmbH (Munich/DE)
Li-COR Biosciences GmbH (Bad Homburg/DE)
Luminex B. V. (`s-Hertogenbosch/NL)
New England BioLabs GmbH (Frankfurt a. M./DE)
OZ Biosciences (Marseille/FR)
PlasmidFactory GmbH & Co. KG (Bielefeld/DE)
Qiagen GmbH (Hilden/DE)
Sanofi Pasteur MSD GmbH (Berlin/DE)
SERVA Electrophoresis GmbH (Heidelberg/DE)
Takara Clontech (Saint-Germain-en-Laye/FR)
TIB Molbiol Syntheselabor GmbH (Berlin/DE)
Visitron Systems GmbH (Puchheim/DE)
Zymo Research Europe (Freiburg/DE)
Booth No.
6
8
9
27
11
13
2
23
20
17
19
1
26
28
29
16
10
4
14
7
21
24
30
15
25
12
18
22
3
5
The member companies of the „Voluntary Self-Regulation of the Pharmaceutical Industry (FSA) e. V.“ have more narrowly defined the FSA code to ensure more transparency. Congress organisers are obliged to inform potential congress
participants in advance about the scope and terms of the support of the pharmaceutical industry. We fulfil this obligation
and inform you about the amount of the sponsorship of companies involved:
Abbott GmbH & Co. KG (Wiesbaden/DE) • Silver Sponsor • 3.500 EUR
Sanofi Pasteur MSD GmbH (Berlin/DE) • Industrial Exhibition • 1.650 EUR
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p 105
Floor Plan
2nd Floor
1st Floor
Catering
Poster Exhibition
Ground Floor
Registration Desk
Information Booth
Conference Bags
Internet-Point
Catering
ENTRANCE
CONFERENCE
Basement
Poster Exhibition
Foyer
Hall
p 106
Site Map
1 Vom-Stein Haus
2 Lecture Halls/Speakers Ready Room
Bäc
kerg
asse
1
P
Promenade
er Tim
2
Schlossplatz
H
Krum
m
3 min
pen
Wilme
rgasse
e
ß
stra
lder
e
f
e
Jüd
Frauenstraße
Überwasserstraße
n
hage
Katt
P
Promenade
Schlossplatz 5
Schlossgarten
p 107
General Information
Conference Website
You will find current information on our website at www.virology-meeting.de.
Language
The conference language is English.
Registration
Registration Fees on-site
Regular (GfV-Member)
Regular (Non-Member)
Day ticket
Student*(GfV-Member)
Student* (Non-Member)
Conference Dinner (8 April 2016)
Regular
Student*
Accompanying Person
* Confirmation of status is required.
General Terms and Conditions
Please find all details on our website at www.virology-meeting.de.
200 EUR
250 EUR
120 EUR
100 EUR
170 EUR
40 EUR
20 EUR
40 EUR
Opening Hours
Wednesday Thursday Friday
Saturday
11.30–21.30 08.00–17.30 08.00–19.3008.00–10.45
Poster Exhibition
19.00–21.30
08.30–19.00
08.30–19.30
–
Registration Desk/
10.00–19.15 07.30–19.00 07.30–17.3007.30–13.00
Speakers Ready Room/Cloakroom
Education Credits and Certification
The conference is requested by the “Medical Chamber of Westfalen-Lippe”
(Ärztekammer Westfalen-Lippe) as follows:
6 April 2016
Category B 3 Points
7 April 2016
Category B 6 Points
8 April 2016
Category B 6 Points
9 April 2016
Category B 3 Points
For certification all attendants are required to sign the certification list near the registration daily. Certificates of attendance may be picked up upon leaving the conference at
the registration desk.
state at printing
p 108
WIRED
FOR TRANSFORMATION
Serologische
und Molekulare
Diagnostik in der
Infektiologie –
State of the Art
CHOOSE TRANSFORMATION
ADD-00057551_DE Mar 2016
General Information
Poster Prizes
All posters will be rated according to scientific basis and visual appearance. The
three best posters will be awarded.
Abstracts
All abstracts will be provided as a pdf-file on a memory stick. You will receive one
at the booth from Hologic Deutschland GmbH, booth number 10.
The pdf-file is also available on the website at www.virology-meeting.de.
Catering and Lunch
Tea, coffee, refreshments and snacks will be provided during the official programme
breaks and poster sessions within the industrial exhibition areas (please refer to pages
108–110). Free lunch boxes will be offered on Thursday and Friday during the industrial
symposia as well as within the industrial exhibition areas.
Cloakroom
The cloakroom can be found in the Central Auditorium Building – Schlossstraße 2.
Coats and luggage can be dispensed for free.
Internet
A wireless internet access (wifi) is available in the main building. You will receive
detailed information at the registration desk.
Furthermore, internet points are provided within the industrial exhibition on the ground
floor (please see pages 108–110).
Public Transport
All participants will receive a free ticket which entitles to any number of bus and rail
rides within the municipal area of Münster including night busses from
6–9 April 2016. Tickets of public transport as well as a map of Münster are available at
the registration desk.
p 110
27th Annual Meeting of
the Society for Virology
Save the Date
© PhilippN l wikimedia.com
DVV
Gesellschaft für Virologie e. V. (GfV)
und
Deutsche Vereinigung zur Bekämpfung
der Viruskrankheiten e. V. (DVV)
© 99173780 l Blackosaka • 90481797 l yurkaimmortal l fotolia.com
22–25 March 2017
Marburg • Germany
Philipps-University Marburg
Keynote speaker
Adolfo Garcia-Sastre │New York, USA
Thijs Kuiken │Rotterdam, the Netherlands
Andrew Mehle │Wisconsin, USA
Kanta Subbarao │Bethesda, USA
Jeffrey Weiser │ New York, USA
Registration Open!
For Registration and
Abstract submission
please visit the website
of the FluResearchNet:
www.fluresearchnet.de
Symposium
2016
National
on Zoonoses Research
13 – 14 October | Berlin
Steering Committee
Stephan Ludwig | Münster
Martin H. Groschup | Isle of Riems
Sebastian C. Semler | Berlin
Social Programme
Get-Together • Wednesday, 6 April 2016
We are looking forward to welcoming you to the Get-Together on
Wednesday at 19.15 within the industrial exhibition in the Vom-SteinHaus. Enjoy a first meet and greet with your colleagues and other
delegates in a relaxed atmosphere. The Get Together is included in
the registration fee. At the same time, you can visit the Poster Session 1 and meet the presenting authors at their posters for inspiring
discussion.
© Jan Reichel - Fotolia.com
Social Evening • Friday, 8 April 2016
We would like to welcome you to our conference dinner which will be
held at the “Speicher 10” in Münster! During the evening you are
invited to exchange and discuss current work and research findings
with your colleagues and friends while you enjoy the buffet. Later you
simply can relax or dance to the music of “Daniel Ligges & Band”.
These four professional musicians guarantee prime entertainment
and a ripping stage show.
Location
Speicher 10
An den Speichern 10
48157 Münster
Date
Friday, 8 April 2016
Time20.00–02.00
© Daniel Ligges & Band
There will be a bus shuttle provided for the ride from the venue to the “Speicher 10” and back at
the following times:
Forward Run
Way Back
p 114
19.40 (meeting point: Central Auditorium Building – Schlossplatz 34)
from 22.00–02.00
9th International
Filovirus Symposium
SEPTEMBER
2017
13–16 MARBURG
www.filovirus-meeting.com
SAVE the DATE
© pkproject - #93622169/yurkaimmortal - #90481833 - fotolia.com
Index of Presenting Authors and Chair Persons
A
Abada, E.
75
Abdelaziz, M.
86
Abdellatif, M.
62
Abdelwhab, E.-S.
82
Abdelwhab, E.-S. M.
40
Abdullah, Z.
75
Abdurahman, S.
64
Aberle, J. H.
68
Abicht, J.-M.
98
Abken, H.
71
Abraham, L.
25
Adams, O.
39, 45, 100
Adigbli, G.
86
Adler, B.
63
Adler, H.
37, 43
Adu-Sarkodie, Y.
99
Aebischer, A.
73, 94
Ahmed, E.
75
Ahola, T.
41
Akalin, A.
93
Akca, Y.
82
Akgül, B.
37
Akhmetzyanova, I.
33, 68
Akhras, S.
60, 84
Akoua-Koffi, C. G.
45
Alam El-Din, H.
76
Alavian, S. M.
77
Alawi, M.
30, 62, 69
Albrecht, J.-C.
41
Aldabbagh, S.
100
Alemayehu, A. E.
97
Alexandrov, A.
48
Alt, M.
79
Altintoprak, K.
61
Altmann, B.
61
Alves, M. J.
70
Amaro, F.
70
Ambiel, I.
25
Ameres, S.
86
Ampofo, W. K.
46
Anastasiou, O. E. 99
Anders-Össwein, M.
26
Anderson, F.
21
Andersson, A.
61
p 116
Andino, R.
15, 49
Andreas, Z.
36
Andree, M.
100
Angelovich, T. A.
87
Anggakusuma
57, 59
Anhlan, D.
64
Anja, S.
84
Antczak, D. F.
66
Arias, A. A.
47
Arnold, U.
93
Asante, I. A.
46
Asbach, B.
72, 84, 86
Aslam, R.
78
Astolfi-Ferreira, C.
89
Ataíde, M.
29
Auerswald, H.
90
Avota, E.
68, 83
Awuni, J.
46
Ayadi, W.
76
Aydilllo, T.
21
Aydin, I.
21
Ayoubian, H.
88
Azadmanesh, K.
77
Azucena, C.
36
B
Bächlein, C.
30, 69
Bäcker, M.
60
Backes, S.
56
Bader, M.
21
Bagnewski, L.
79
Bahsi, H.
92
Baiker, A.
75
Bailer, S.
71, 74, 85
Bajagic, M.
87
Baker, M.
66
Baldauf, H.-M.
25
Balistreri, G.
41
Balkema-Buschmann, A. 69
Banbura, M. W.
63, 93
Banda, D.
59
Banki, Z.
32, 86
Bankwitz, D.
38, 74
Bannach, C.
52
Bannert, N.
23, 40, 61, 64
83, 97
Banning, C.
25
Banse, P.
51
Bao, Q.
62
Barchet, W.
22, 57
Barhoumi, W.
46
Bartenschlager, R.
22, 24
57, 77
Barth, E.
55
Barthel, S.
43
Bartikowski, H.
25
Bartmeyer, B.
23, 97
Bartusch, C.
95
Basuki, A.
72
Bauer, A.
96
Bauer, D.
79
Bauer, T.
68
Bauerfeind, R.
21, 36, 74
Baumann, A.
51
Baumgarten, A.
79
Baumgärtner, W.
69, 88
Bayer, K.
25
Bayer, W.
32, 81, 83, 84
Beauclair, G.
79
Becher, D.
61
Becher, P.
30, 69, 88
Becherel, O.
56
Beck, S. 15, 22, 30, 31, 32, 46
47, 54, 62, 70, 74, 87, 91, 95
Becker, C.
30
Becker, D.
22
Becker, J.
43, 60
Becker, K. A.
68
Becker, M.
54
Becker, Stefan 74
Becker, Stefanie 46, 70
Becker, Stephan 22, 30, 32, 47
62, 87, 91, 95
Becker, T.
95
Beckers, J.
43
Beer, M.
15, 23, 30, 46, 62
63, 70, 73, 85, 94
Behner, L.
73
Behrendt, P.
38, , 57
Behrendt, R.
96
Behrens, S.-E.
58, 63
Beineke, A.
89, 96
Bejarano, D.
62
Bell-Sakyi, L.
30
Bellstedt, P.
77
Belov, V.
26
Belshaw, R.
15, 49
Ben ayed-Guerfali, D.
76
Benchoua, A.
88
Benda, C.
24
Bender, S.
22, 57
Benkirane, M.
96
Bensaid, A.
69
Bergelson, J.
55
Berger, A.
60
Berger, E.
30
Bergmann, M.
60
Bergmann, Th.
71
Bergmann, To.
66
Bergs, S.
40
Berre, S.
47
Berscheminski, J.
47, 76
Bertram, S.
44, 46
Bestebroer, T. M.
69
Beyersdorf, N.
68
Bezgovsek, J.
76
Bi, Y.
70, 90
Bialy, D.
21
Biasiotto, R.
41
Biedenkopf, N.
62
Biehl, M.
78, 92
Biesinger, B.
15, 37, 41, 83
Binder, M.
24, 57
Binz, A.
21, 36, 74
Blaas, D.
51
Blank, A.
48
Blazevic, J.
72
Bleiholder, A.
84
Bloch, N.
57
Bloch, O.
64
Blome, S.
78, 85
Blomström, A.-L.
57
Bock, C. T.
38
Bock, H.
60
Bodmer, B. S.
85
Boehme, P.
33
Bogdanow, B.
91, 97
Bogner, E.
36, 79
Bogomolov, P.
48
Bohn-Wippert, K.
77
Bohne, J.
33, 72
Bokorova, S.
40
Bolduan, S.
94
Bollenbach, A.
36
Boller, K.
31, 84
Bolte, H.
28, 44, 62
Boltengagen, A.
93
Bongard, N.
83
Börgeling, Y.
64
Borger, R.
100
Borkner, L.
29, 87
Börner, K.
62
Borst, E. M.
28, 42
Börstler, J.
70
Börtlein, C.
83
Bosch, B.-J.
90
Bosch, P.
59
Boscheinen, J. B.
58
Bosse, J. B.
25
Böttcher, S.
48, 99
Boujon, C. L.
60, 69, 97
Boukhallouk, F.
53
Boulant, S.
15, 21, 22, 25
Boulos, R. E.
55
Bourquain, D.
95
Bouzalas, I.
60, 69
Bouzas, N. F.
96
Bracher, F.
47
Brack-Werner, R.
94
Brady, N.
52
Brancale, A.
80
Brandariz-Nuñez, A.
, 44
Brandmüller, C.
59, 86
Brandt, S.
77
Brangwynne, C.
25
Braun, P.
47
Bremer, B.
29, 38
Bremer, C.
29
Bremer, V.
23, 97
Brennan, A.
42, 45
Brennan, C. A.
45
Bresk, A.
86
Brewitz, A.
29, 66
Brey, C.
78
Brillen, A.-L.
23
Bringolf, F.
36, 51
Brinkert, P.
52
Brinkmann, C.
59
Brinkmann, J.
66
Brinkmann, M. M.
56
Britten, C.
42
Brizic, I.
63
Brocchi, E.
85
Broccolo, F.
100
Brockmeyer, N.
48
Brodbeck, S.
37
Broering, R.
43, 56
Brönstrup, M.
54
Brost, R.
92
Brown, R. J. P.
36, 38, 88
Bruening, J.
51
Bruggmann, R.
60
Brune, W. 41, 43, 62, 92, 94
Brunnemann, A.-K.
80
Brunotte, L.
44
Bruss, V.
25, 73
Bruun, T.-H.
84
Brzezicka, J.
63
Buch, A.
21, 36, 74, 79, 96
Buchholz, C.
71
Büchner, S. M. 43
Buchy, P.
90
Bücker, R.
46
Buczolich, K.
64, 89
Budeus, B.
68
Budt, M.
15, 24, 78, 83
Bürck, C.
47
Burger, B.
47
Burkard, T.
91
Busch, D.
68
p 117
Busch, Jo.
Busch, Ju.
Busch, M.
Bussey, K. A.
87, 89
33
79
56
C
Cadar, D.
46, 70
Cai, X.
21
Calvignac-Spencer, S.
98
Camdereli, J.
60
Canbay, A.
99
Cao, Y.
44
Cao, Z.
70
Carranza, C.
89
Casalegno, R.
87
Casanova, J.-L.
47
Cattaneo, R.
53
Cavalcanti-Adam, A.
21
Cavalleri, J.-M. V.
88
Chan, B.
24, 56
Chaudhry, M. Z. 87
Chelbi, I.
46
Chemin, I.
54
Chen, H.-W.
64, 89
Chen, M.
65
Chen, S.
43
Chen, W.
64, 70, 89
Chen, X.
43
Chen, Y.
38
Cherni, S.
46
Chey, S.
87, 89
Chi, H.
20, 54, 69, 70, 82
Chiang, C.-M.
37
Chin, Y. E.
28
Chmielewska, A.
93
Chu, D.
70
Chudy, M.
60, 78
Cichutek, K.
71, 92
Čičin-Šain, L. 29
Ciurkiewicz, M.
96
Çizmeci, Ş. G. 82
Claus, C. 15, 47, 72, 88, 89
Claus, P.
96
Clement, B.
78
p 118
Clos, J.
Cochet-Bernoin, M.
Cojocaru, R.
Colinge, J.
Collarile, S.
Collenburg, L.
Colonna, M.
Colston, J.
Commey, A. N. O.
Convery, O.
Conzelmann, K.-K.
Cooper, P.
Corall, S.
Cordes, N.
Corman, V. M.
Cornberg, M.
Corrales-Aguillar, E.
Couderc, T.
Coulpier, M.
Couté, Y. Crequer, A.
Cribier, A.
Crowe, S. M.
Cui, S.
Culig, Z.
Cullen, B. R.
Cymerys, J.
Czech-Sioli, M.
46, 70
88
45
55
80
83
29
32
46
83
90
97
37
21
70
29, 38
66
47
88
92
47
96
87
41
34
62
63, 93
28, 95
D
Dachraoui, K.
Daeumer, M.
Damas, M.
Dandri, M.
Daniel, C.
Daniels-Haardt, I.
Dapa, S.
Daugs, A.
Däumer, M.
Daumke, O.
Dávid, S. Davison, A. J.
De Gruyter, H. L. M.
de Jong, S. J.
46
79
43
77
91
45
54
64
80
55
71
99
85
47
De la Torre, D.
89
de Mutsert, G.
85
De Rosa, M.
80
de Toledo-Piza, A. R.
79
Deeg, C.
98
Degen, O.
61
Deinhardt-Emmer, S.
80
Dekhtiarenko, I.
93
Delcuratolo, M.
37
Demminger, D.
42
Deng, W.
23
Dennehy, K.
68
Denner, J. 46, 60, 62, 82, 84
87, 88, 98
Denton, A. E.
32
Derking, S.
69
Derua, R.
44
Desrosiers, R.
52
Devignot, S.
91
Dewi, B. E.
72
Dezeljin, M.
93
Dhingra, A.
79, 99
Di, Nunzio, F.
93
Diaz-Griffero, F.
44, 93
Dick, A.
55
Dickow, J.
24
Diederich, S.
69
Diedrich, S.
48, 81, 99
Dieringer, B.
81
Dietrich, I.
57
Dietrich, U.
40
Dietz, A.
74
Dietzel, E.
72
Dijkman, R.
57
Diken, M.
42
Dilcher, M.
40
Ding, Q.
47
Dirks, M.
79, 80
Dittmer, A.
79
Dittmer, U. 15, 24, 32, 33, 39
68, 79, 83, 84
Dobner, T.
28, 47, 76
Doerflinger, S.
63
Doerrbecker, J.
36
Döhner, K.
21, 36, 74
Dold, C.
34
Dölken, L.
88, 94
Döllinger, J.
90
Dolnik, O.
32
Donhauser, N.
32
Donnerhak, C.
94
Donos, A.
45, 80
Douam, F.
47
Drabczyk, M.
33
Drabig, A.
29
Drach, J. C.
79
Draenert, R.
94
Drago, F.
100
Draßner, C. 91
Dreer, M.
37
Dremsek, P.
61
Drewes, S.
46
Drexler, I.
15, 29, 81
Drexler, J. F. 15, 30, 40, 53, 61
Drosten, C.
30, 40, 53
69, 70, 82
Dubrau, D.
62
Ducroux, A.
22, 57
Dudek, A.
28
Dudek, N.
66
Dudek, S. E.
81
Dunay, G. A.
48, 61
Dunder, J.
25
Dunham, E.
91
Duong, V.
90
Dussart, P.
90
Duverlie, G.
57
Duwe, S.
77
Dzieciatkowski, T. 63, 79, 93
E
Ebell, W.
Eber, F. J. Eberle, F.
Ebert, T.
Eckerle, I.
Eder, V.
Egerer, L.
48
36
57
96
46
45, 80
86
Ehlers, B.
60, 70, 98
Ehrhardt, A.
15, 33, 71, 78
Ehrhardt, C. 15, 32, 41, 58, 64
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©
International Endotoxin and Innate Immunity Society
14th Biennial Meeting
www.mediaserver.hamburg.de
22–24 September 2016
Hamburg/Germany
DEaDlInE for abStract SubmISSIon:
30 April 2016!
•
•
•
•
•
•
lipopolysaccharide transport
Structures of lipopolysaccharide
outer membrane Vesicles
Plant Innate Immunity
Epigenetic control of Innate Immunity
antimicrobial Peptides and
(Gram-negative) Sepsis
• Endotoxin Detection
• targeting Innate Immunity
www.ieiis2016.de
© Wolfgang Meinhardt I wikimedia.com
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p 133
Upcoming Conferences and Meetings
Frontiers of Retrovirology 2016
Complex retroviruses, retroelements and their hosts
12–14 September 2016 • Erlangen (DE)
www.frontiers-of-retrovirology.com
109th Annual Meeting of the German Zoological Society (DZG)
14–17 September 2016 • Kiel (DE)
www.dzg-meeting.de
14th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS)
22–24 September 2016 • Hamburg (DE)
www.ieiis2016.de
5th International Influenza Meeting
25–27 September 206 • Münster (DE)
www.fluresearchnet.de
46th Annual Meeting German Society for Immunology
27–30 September 2016 • Hamburg (DE)
Abstract-Deadline 23 May 2016
www.immunology-conference.de
National Symposium on Zoonoses Research
13–14 October 2016 • Berlin (DE)
27th Annual Meeting of the Society for Virology (GfV)
22–25 March 2017 • Marburg (DE)
9th International Symposium on Filoviruses
13–16 September 2017 • Marburg (DE)
www.filovirus-meeting.com
p 134
Cytotect® CP Biotest
Sicher und zuverlässig im gezielten
Management der CMV-Infektion nach
Transplantationen
Cytotect® CP Biotest: Risiken erkennen – professionell handeln
Cytotect®CP 100 E/ml Infusionslösung Wirkstoff: Cytomegalie-Immunglobulin vom Menschen Zusammensetzung: 50 mg/ml Plasmaproteine vom
Menschen (mind. 96 % Immunglobulin G), Gehalt an Antikörpern gegen CMV von 100 E*/ml (* Einheiten d. Referenzpräp. d. Paul-Ehrlich-Instit.), Höchstgehalt an IgA: 2000 mcg/ml, Glycin, Wasser f. Injektionszwecke. Anwendungsgebiete: Prophyl. klin. Manifestationen einer CMV-Infekt. b. Pat. unter immunsuppr. Ther., insb. Transplantat-Empf.. Gegenanzeigen: Überempfindlichkeit gegen jegl. Bestandteile od. hum. Immunglobuline; insb. b. Pat. mit IgAAntikörpern. Nebenwirkungen: Gelegentlich: Kopfschmerzen, Schwindel, Erbrechen, Übelkeit, Gelenkschmerzen, leichte Rückenschmerzen, niedriger
Blutdruck, Schüttelfrost, Fieber, allerg. Reaktionen. Selten: Überempfindlichkeitsreakt. m. plötzl. Blutdruckabfall, Einzelfälle bis z. anaphylakt. Schock,
vorrübergeh. Hautreaktionen. Sehr selten: thromboembol. Reakt. wie Myokardinfarkt, Schlaganfall, Lungenembolie, tiefe Venenthrombose. Nicht bekannt: revers. asept. Meningitis, resers. hämolyt. Anämie, Anstieg d. Serumkreatinin-Spiegels u./od. akutes Nierenversagen. Lagerung: Im Kühlschrank
lagern (2°C–8°C). In der Originalverpackung aufbewahren, um den Inhalt vor Licht zu schützen. Nicht einfrieren. Biotest Pharma GmbH, Landsteinerstr.
5, 63303 Dreieich Verschreibungspflichtig. Stand der Information August 2015
Biotest Pharma GmbH · Postfach 10 20 40 · 63303 Dreieich · www.biotest.de

here - 27th Annual Meeting of the Society for Virology

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