Scientific Program - 10th International Conference on

Transcription

ICFTD 2016
Program August 31, 2016
Scientific Program
10th International Conference on
Frontotemporal Dementias
August 31–September 2, 2016
Munich (GERMANY)
www.icftd2016.de
1
ICFTD 2016
12:15–12:30
Room
Chairs
Opening
Lecture Hall
Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)
12:30–13:50
Room
Chairs
Session 1: FTLD: current perspectives - future directions
Lecture Hall
Bruce Miller (San Francisco, CA/US), Julie Snowden (Manchester/GB)
12:30
Changing perspectives on frontotemporal dementia
Julie Snowden (Manchester/GB)
12:55
Frontotemporal dementia neuroanatomy: onset, spread, and implications for
treatment
William S. Seeley (San Francisco, CA/US)
13:20
O1
Social and Economic Burden of Frontotemporal Degeneration
James Galvin (Boca Raton/US), David Howard (Atlanta/US), Nadine Tatton, Sharon
Denny (Radnor/US)
13:35
O2
Toward tau PET imaging in FTLD: An update
Brad Dickerson, Scott McGinnis, Sara Makaretz, Christina Caso, Aaron Schultz,
Keith Johnson (Charlestown/US)
14:20–15:55
Room
Chairs
Session 2: Social cognition and behavior: challenges and interventions
Lecture Hall
Adrian Danek (Munich/DE), Mario Mendez (Los Angeles, CA/US)
14:20
Current concepts of social cognition and assessment in FTD
Bruno Dubois (Paris/FR)
14:45
Empathy and emotional processing in FTD
Katherine Rankin (San Francisco, CA/US)
15:10
An analysis of the trajectories of illness severity measurements in behavioral variant
frontotemporal dementia
Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)
O3
15:25
O4
15:40
DB1
Phenotype, neuropsychology and psychopathology of C9orf72 mutation carriers from
the German FTLD-Consortium
Janine Diehl-Schmid, Carola Rossmeier (Munich/DE), Sarah Straub, Theresia Kelm
(Ulm/DE), Johannes Kornhuber (Erlangen/DE), Klaus Fliessbach (Bonn/DE), Timo
Grimmer (Munich/DE), Alexander Kehl, Markus Otto (Ulm/DE), Matthias L. Schroeter
(Leipzig/DE), German FTLD-Consortium (Ulm/DE)
Reward deficits in behavioral variant frontotemporal dementia include insensitivity to
negative stimuli
David Perry, Samir Datta, Virginia Sturm, Kristie Wood, Jessica Zakrzewski, Bruce
Miller, Joel Kramer, Howard Rosen (San Francisco, CA/US)
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ICFTD 2016
15:42
DB2
Embodied Cognition of Dynamic Emotion in Frontotemporal Lobar Degeneration
Charles Marshall, Chris Hardy, Lucy Russell, Camilla Clark, Katrina Dick, Emilie
Brotherhood, Jennifer Nicholas, Jonathan Rohrer, James Kilner, Jason Warren
(London/GB)
15:44
Longitudinal decline in cognitive functioning in presymptomatic frontotemporal
dementia
Janne Papma, Lize Jiskoot, Elise Dopper, Tom Den Heijer, Reinier Timman, Rick
Van Minkelen, John Van Swieten (Rotterdam/NL)
DB3
15:46
DB4
The impact of context on emotion decoding in frontotemporal dementia
Fiona Kumfor (Randwick, Sydney, Sydney/AU), Agustin Ibañez (Buenos Aires,
Santiago/AR), John Hodges, Olivier Piguet (Randwick, Sydney, Sydney/AU)
15:48
Neuropsychological profiles in behavioural variant Frontotemporal Dementia and
Psychiatric disorders
Everard Vijverberg (Amsterdam, The Hague/NL), Sigfried Schouws, Paul David
Meesters, Sietske Sikkes (Amsterdam/NL), Esmee Verwijk (The Hague/NL), Hannie
Comijs, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols
(Amsterdam/NL)
DB5
15:50
DB6
Frontotemporal Dementia in Patients of African Descent
Keith Josephs (Rochester/US), William Hu (Atlanta/US), Argye Hillis (Baltimore/US),
Bradley Dickerson (Boston/US), Neill Graff-Radford (Jacksonville/US), Cameron
Davis (Baltimore/US), Rufus Akinyemi, Adesola Ogunniyi (Ibadan/NG), Nilufer Taner
(Jacksonville/US), Jonathan Graff-Radford (Rochester/US), Amza Ali (Mona/JM),
David Tang-Wai (Toronto/CA), Meredith Wicklund (Gainesville/US), Florence
Pasquier, Florence Lebert (Lille/FR), Julie Snowden (Manchester/GB), Nick Fox
(London/GB), Murray Grossman (Philadelphia/US), Chiadi Onyike (Baltimore/US)
15:55–17:30
Room
Postersession I - Caregiver
Ballroom
P35
Spouses' experience of behavioural-variant frontotemporal dementia in the prediagnostic phase
Kirrily Rogers (Parkville/AU), Amy Brodtmann, David Darby (Heidelberg, Box
Hill/AU), Vicki Anderson (Parkville/AU)
P36
Emotional Behavior in Dementia Patients and Spousal Caregivers: Rrelationship with
Caregiver Depression
Alice Verstaen, Anna Sapozhnikova, Sandy Lwi, Marcela Otero, Casey Brown, Dyan
Connelly, Robert Levenson (Berkeley/US)
P37
The Marte Meo-concept as a useful tool in understanding and counseling in FTD
Ursula Becker (Alfter/DE)
P38
Do neuropsychiatric symptoms lead to nursing home placement in bvFTD?
Differences and similarities between community and nursing home residents
Clarissa Giebel (Manchester/GB), Rachel Winson (Norwich/GB), David Knopman
(Rochester/US), Eneida Mioshi (Norwich/GB)
P39
Dimensions and Predictors of Perceived Burden Among Caregivers of Patients with
Frontotemporal Degeneration
James Galvin (Boca Raton/US)
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ICFTD 2016
P40
Unity with Creativity: A new model to leverage rare disease advocacy organization
expertise into high-quality local support for FTD caregivers
Sharon Denny, Bridget Moran (Radnor/US)
P41
Characteristics of caregiver burden among mild frontotemporal lobar degeneration
patients: comparison between behavioral variant frontotemporal dementia and
semantic dementia with right- and left-sided predominant cerebral atrophy.
Asuka Koyama, Ryuji Fukuhara, Yusuke Miyagawa, Maki Hotta, Mamoru Hashimoto,
Manabu Ikeda (Kumamoto/JP)
P42
Family experiences of living with behavioural variant Frontotemporal Dementia
(bvFTD): implications of a qualitative longitudinal research study for coping and
interventions
Jan Oyebode, Jenny LaFontaine (Bradford/GB), Michael Larkin (Birmingham/GB)
P43
An intervention program for caregivers of early-onset dementia patients with frontal
behavioral changes: an explorative study increasing their sense of competence
Flora Gossink, Yolande Pijnenburg, Philip Scheltens, Rikie Kleverwal, Aafke Pera,
Nicole Korten, Max Stek, Rose-Marie Droes, Annemiek Dols (Amsterdam/NL)
P44
Family repercussions as a consequence of the alterations of social cognition present
in a patient diagnosed with frontotemporal dementia - behavioral variant
Daniel Martinez Martinez, Delver Amaury Garzón Muñoz, Johana Andrea Ramírez
Torres, Adelaida Bedoya Salcedo, Milena García García (Bogotá/CO)
P45
Care for people with Young Onset Dementia: A web-based intervention aiming to
support family carers
Susanna Saxl, Helga Schneider-Schelte (Berlin/DE)
P46
Caregivers' Attitudes Toward Family Participation in Frontotemporal Degeneration
Biomarker Research
Courtney Igne (Philadelphia/US), Lauren Massimo (University Park, PA/US), Corey
McMillan, Rachael Langey, Collin York, Kim Firn, Olga Kofman, Amy Halpin, Murray
Grossman (Philadelphia/US)
P47
Service needs in Young Onset Dementia: How ‘closest’ relatives balance being a
carer, being a care manager and meeting their own needs.
Jan Oyebode (Bradford/GB), Bridget Jones (Guildford/GB), Heather Blakey
(Leeds/GB), Sahdia Parveen (Bradford/GB), Christian Bakker (Nijmegen/NL), Joany
Millenaar, Marjolein de Vugt (Maastricht/NL), Alexander Kurz (Munich/DE), Heather
Gage (Guildford/GB)
P48
The CARE Pathway Model for Dementia: Integrating Psychosocial and
Rehabilitative Strategies for Care of Persons with FTD Disorders
Darby Morhardt, Sandra Weintraub, Becky Khayum, Emily Rogalski, Marsel
Mesulam (Chicago/US)
P49
Dissociation of Clinical Diagnostic and Caregiver Distress Neuropsychiatric Features
in FTD
Lydia Hatfield, Jennifer Wynne Taylor, Matthew Harris, Nansi Greger-Holt, Daniel I.
Kaufer (Chapel Hill/US)
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ICFTD 2016
15:55–17:30
Room
Postersession I - Social cognition and behavior
Ballroom
P50
In extremis: decision-making deficit in behavioral variant frontotemporal dementia
Guilhem Carle, Nicolas Borderies, Carole Azuar, Aurélie Guignebert, Maeva Camus,
Goeffroy Gagliardi, Raphael Le Bouc, Richard Levy, Mathias Pessiglione (Paris/FR)
P51
Moral judgments in frontotemporal dementia
Ingo Uttner, Lukas Petersdorff, Sarah Anderl-Straub, Elisa Semler, Sarah Böhm,
Dorothée Lulé (Ulm/DE), Heiner Fangerau (Düsseldorf/DE), Markus Otto (Ulm/DE)
P52
Cross frequency coupling during response inhibition in behavioural variant
Laura Hughes, James Rowe (Cambridge/GB)
P53
Prolonged Visual Facial Gaze in Frontotemporal Dementia
Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Liang Li-Jung, Drew R. Carr,
Elvira Jimenez, Robin J Barrows, Valeiry Sabodash, Mario F. Mendez (Los
Angeles/US)
P54
Person-Based vs. Generalized Impulsivity Disinhibition in Frontotemporal Dementia
and Alzheimer’s Disease
Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Drew R. Carr, Joseph P
Barsuglia, Robin J Barrows, Elvira Jimenez (Los Angeles/US), Grace J Lee (Loma
Linda/US), Mario F. Mendez (Los Angeles/US)
P55
Emotion and Moral Dilemmas in Behavioral Variant Frontotemporal Dementia
Sylvia S. Fong (Los Angeles/US), Carlos D. Navarrete (East Lansing/US), Sean E.
Perfecto, Andrew R. Carr, Elvira E. Jimenez, Mario F. Mendez (Los Angeles/US)
P56
The pitfall of behavioral variant frontotemporal dementia mimics despite
multidisciplinary application of the FTDC criteria
Welmoed Krudop, Annemiek Dols, Cora Kerssens, Piet Eikelenboom, Niels Prins,
Christiane Möller, Siegfried Schouws, Didi Rhebergen, Eric Exel, van, Wiesje Flier,
van der, Sietske Sikkes, Philip Scheltens, Max Stek (Amsterdam/NL)
P57
Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral
prefrontal cortex in humans
Edward Huey, Seonjoo Lee, Adam Brickman, Masood Manoochehri, Erica Griffith,
D.P. Devanand, Yaakov Stern (New York, NY/US), Jordan Grafman (Chicago, IL/US)
P58
Combined intensity ratings of congruent and incongruent facial emotions highly
discriminate between behavioral-variant frontotemporal dementia and major
depressive disorder
Isabelle Chiu (Basel/CH), Olivier Piguet (Sydney/AU), Janine Diehl-Schmid, Lina
Riedl (Munich/DE), Johannes Beck, Thomas Leyhe, Edith Holsboer-Trachsler
(Basel/CH), Manfred Berres (Koblenz/DE), Andreas U. Monsch, Marc Sollberger
(Basel/CH)
P59
Executive functioning and mental attribution predict environmentally-driven
behaviours in behavioural variant frontotemporal dementia
Emma Flanagan (Norwich/GB), Maxime Bertoux (Norwich, Paris/GB), Bruno Dubois,
Valérie Hahn, Elodie Guichart-Gomez (Paris/FR), Eneida Mioshi (Norwich/GB), Marie
Sarazin (Paris/FR), Michael Hornberger (Norwich/GB)
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ICFTD 2016
P60
Emotion recognition in presymptomatic CHMP2B mutation carriers
Jette Stokholm, Peter Roos, Jørgen E. Nielsen (Copenhagen/DK), Adrian M. Isaacs
(London/GB), Jerry Brown (Cambridge/GB), Peter Johannsen (Copenhagen/DK)
P61
Emotion network breakdown relates to baseline autonomic dysfunction in behavioral
variant frontotemporal dementia
Virginia Sturm, Jesse Brown, Alice Hua, Sandy Lwi, Howard Rosen, Bruce Miller,
Robert Levenson, William Seeley (San Francisco/US)
P62
The Eating Behavior Inventory (EBI): a new clinical tool for the early diagnosis of
frontotemporal dementia.
Carole Azuar, Adriana Amaya, Maeva Camus, Aurelie Funkiewiez, Thomas Mauras,
Richard Levy, Isabelle Le Ber, Bruno Dubois (Paris/FR)
P63
Clinical types of FТD in elderly patients of Alzheimer’s disease outpatients clinic
(clinical-neuropsychological study)
Yana Fedorova, Irina Roshchina, Elena Ponomareva, Igor Kolykhalov, Natalia
Mikhаylova, Svetlana Gavrilova (Moscow/RU)
P64
Functional dissociation between anterior temporal lobe and inferior frontal gyrus in
the processing of dynamic body expressions: Insights from behavioral variant
Jan Jastorff, François-Laurent De Winter, Jan Van Den Stock, Mathieu
Vandenbulcke (Leuven/BE)
P65
Determinants of theory of mind performance in Alzheimer's disease
Siddharth Ramanan (Bangalore/IN), Leonardo Cruz de Souza (Belo Horizonte/BR),
Marie Sarazin (Paris/FR), Antonio Lúcio Teixeira, Paulo Caramelli (Belo
Horizonte/BR), Bruno Dubois (Paris/FR), Michael Hornberger, Maxime Bertoux
(Norwich/GB)
P66
Brain structural correlates of executive and social cognition profiles in behavioral
variant Frontotemporal Dementia and elderly Bipolar Disorder
Teresa Torralva, Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas
Couto, Indira Cordero (BUenos Aires/AR), Agustin Ibañez, Indira Cordero (Buenos
Aires/AR), Cruz Francy, Pablo Reyes, Diana Matellana (Bogota/CO), Marcelo
Cetkovich, Facundo Manes (Buenos Aires/AR)
P67
Uncovering the neural bases of cognitive and affective empathy loss in the
behavioural-variant of frontotemporal dementia
Muireann Irish, Nadene Dermody, Stephanie Wong, John Hodges, Olivier Piguet
(Sydney/AU)
P68
Multimodal evidence of interoceptive dimensions in neurodegeneration and stroke
Indira García-Cordero, Lucas Sedeño, Teresa Torralva, Laura de la Fuente, Jessica
Ferrari, Clara Rodriguez, Sandra Baez, Adrian Yoris, Sol Esteves, Margherita
Melloni, Paula Salamone, Facundo Manes, Adolfo Garcia, Agustin Ibañez (Buenos
Aires/AR)
P69
Bilingualism effect on cognitive development in Mongolian children
Delgertsetseg Chuluundorj, Nyamsuren Dorjpalam, Chuluundorj Begz
(Ulaanbaatar/MN)
P70
Multidimensional Apathy and Insight in Frontotemporal Lobar Degeneration and
Alzheimer’s Disease
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ICFTD 2016
Ratko Radakovic, Shuna Colville, Denise Cranley, John Starr, Suvankar Pal, Sharon
Abrahams (Edinburgh/GB)
P71
Do you have a strategy? Multimodal signatures of social bargaining in
neurodegeneration and frontal lesion
Margherita Melloni, Teresa Torralva (BUenos Aires/AR), Pablo Billeke (Santiago/CL),
Sandra Baez, Eugenia Hesse, Laura de La Fuente, Agustina Birba, Indira Garcia
Cordero, Adolfo Garcia, Lucas Sedeño, Facundo Manes, Agustin Ibañez (BUenos
Aires/AR)
P72
Changing the artistic experience in Behavioral variant of Frontotemporal Dementia
Claire Boutoleau-Bretonniere (Nantes, Bron/FR), Cédric Bretonnière, Christelle
Evrard, Laetitia Rocher (Nantes/FR), Audric Mazzietti, Olivier Koenig (Bron/FR),
Martine Vercelletto, Pascal Derkinderen (Nantes/FR), Catherine Thomas-Antérion
(Bron, Lyon/FR)
P73
Distinct neuropsychiatric subtypes of behavioural variant FTD have different
functional profiles
Claire M O'Connor, Lindy Clemson, Cassandra Kaizik, Naomi Daveson, John R
Hodges, Sharpley Hsieh, Olivier Piguet (Sydney/AU), Eneida Mioshi (Norwich/GB)
P74
Neural basis of motivational approach and withdrawal behaviors in
neurodegenerative disease
Shunichiro Shinagawa (Tokyo, San Francisco/JP), Adhimoolam Babu, Virginia
Sturm, Tal Shany-Ur, Parnian Toofanian Ross, Pardis Poorzand, Scott Grossman,
Bruce Miller, Katherine Rankin (San Francisco/US)
P75
Categorization impairment in bvFTD, PSP and AD
Béatrice Garcin, Emmanuelle Volle, Aurelie Funkiewiez, Nicolas Defoor, Bruno
Dubois, Richard Levy (Paris/FR)
P76
So close yet so far: executive contribution to memory processing in behavioural
Maxime Bertoux (Norwich/GB), Siddharth Ramanan (Bangalore, India./IN), Andrea
Slachevsky, Carolina Delgado, Fernando Henriquez, Gada Musa (Santiago,
Chile/CL), Foudil Lamari (Paris, France/FR), Michel Bottlaender (Saclay, France/FR),
Marie Sarazin (Paris, France/FR), Michael Hornberger (Norwich/GB), Bruno Dubois
(Paris, France/FR)
P77
Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes.
Claire Lansdall, Ian T.S. Coyle-Gilchrist, Patricia Vázquez Rodríguez
(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox
(Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson,
James B Rowe (Cambridge/GB)
P78
Fronto-striatal correlates of behavioural disturbances in behavioural-variant
Maxime Bertoux, Emma Flanagan (Norwich/GB), Olivier Piguet, John Hodges
(Sydney, Australia/AU), Michael Hornberger (Norwich/GB)
P79
The Brain Network Abnormalities Underlying Apathy and Impulsivity in
Frontotemporal Lobar Degeneration.
(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox
(Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson,
James B. Rowe (Cambridge/GB)
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ICFTD 2016
P80
Loss of White Matter Connectivity Related to Apathy and Impulsivity in
Frontotemporal Lobar Degeneration Disorders.
(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox, P.
Simon Jones, Karalyn Patterson, James B. Rowe (Cambridge/GB)
P81
Cognitive profile in the C9ORF72 expansion related frontotemporal lobar
degeneration
Noora-Maria Suhonen (Oulu/FI), Ramona M Haanpää, Tuomo Hänninen, Anne M
Remes (Kuopio/FI)
P82
Frontotemporal dysfunction in elderly patients with bipolar disorder
Yaroslav Kalyn, Elena Shipilova, Irina Roshchina, Yana Vologdina, Tatiana Safarova
(Moscow/RU)
P83
Looking but not seeing: Understanding emotional face perception in behaviouralvariant frontotemporal dementia
Rosalind Hutchings (Randwick/AU), Romina Palermo (Crawley/AU), Jason
Bruggemann (Kensington/AU), John Hodges, Olivier Piguet, Fiona Kumfor
(Randwick/AU)
P84
Should I trust you? Learning and memory of socially relevant information in dementia
Stephanie Wong (Randwick/AU), Claire O'Callaghan (Cambridge/AU), Fiona Kumfor
(Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier Piguet
(Randwick/AU), Michael Hornberger (Norwich/GB)
P85
Motivated to remember? Modulation of value-based learning and memory in
dementia
Stephanie Wong (Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier
Piguet (Randwick/AU), Michael Hornberger (Norwich/GB)
P86
The Awareness of Social Inference Test (TASIT): Application of a short version of the
TASIT for the clinical diagnosis of behavioural-variant frontotemporal dementia
Fiona Kumfor (Randwick, Sydney, Sydney/AU), Cynthia Honan (Launceston/AU),
Jessica Hazelton (Randwick, Sydney/AU), John R. Hodges (Randwick, Sydney,
Sydney/AU), Skye McDonald (Sydney/AU), Olivier Piguet (Randwick, Sydney,
Sydney/AU)
P87
Changes in sexual behaviour and intimacy in frontotemporal dementia: impact on
spousal carers.
Cassandra Kaizik (Randwick/AU), Rebekah Ahmed (Randwick, Sydney/AU), Claire
O'Connor (Sydney/AU), Eneida Mioshi (Norwich/GB), Olivier Piguet, John Hodges
(Randwick, Sydney/AU)
P88
Neurodegeneration With Brain Iron Accumulation Can Mimic Frontotemporal
Dementia
Ahmet Evlice, Hacer Bozdemir, Kezban Aslan (Adana/TR)
P89
Behavioral variant frontotemporal dementia can be conceptualized and individually
predicted with meta-analyses & pattern classification of imaging data
Matthias Schroeter, Sebastian Meyer, Jane Neumann (Leipzig/DE), Angela Laird
(Leipzig/US), Karsten Mueller, Markus Otto (Leipzig/DE)
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ICFTD 2016
P90
Neural correlates of verbal and nonverbal memory for item-item and item-location
information: Evidence from semantic dementia and Alzheimer's disease
Marshall Dalton (Sydney, Australia, London, UK/AU), Michael Hornberger , John
Hodges, Olivier Piguet (Sydney, Australia/AU)
P91
A spatial anticipation deficit is revealed by eyetracking metrics in behavioural variant
frontotemporal dementia.
Silvia Primativo, Camilla Clark, Keir Yong, Jason Warren, Jonathan Rohrer,
Sebastian Crutch (London/GB)
P92
Autonomic and Facial Expressive Emotional Responses: Relationships with Disease
Severity and Frontotemporal Dementia Subtypes
Alice Hua, Sandy Lwi (Berkeley/US), Bruce Miller (San Francisco/US), Robert
Levenson (Berkeley/US)
P93
Processing of auditory conflict in frontotemporal dementia
Camilla Clark, Jennifer Agustus, Jennifer Nicholas, Chris Hardy, Catherine
Mummery, Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren
(London/GB)
P94
Expectation and reward in frontotemporal dementia: the case of music
Camilla Clark, Hannah Golden, Oliver McCallion, Jennifer Nicholas, Miriam Cohen,
Catherine Slattery, Ross Paterson, Alexander Foulkes, Catherine Mummery,
Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)
P95
Longitudinal profiles of autobiographical memory retrieval in FTD
Annu Mothakunnel, Sharpley Hsieh, Ramon Landin-Romero, John R. Hodges, Olivier
Piguet, Muireann Irish (Sydney/AU)
P96
PERSONAL SPACE IN FRONTOTEMPORAL DEMENTIA
Sarah Anderl-Straub, Magdalena Nagl, Jens Dreyhaupt, Hans-Peter Müller, Markus
Otto, Ingo Uttner (Ulm/DE)
P97
All is not lost: Positive behaviors in Alzheimer’s disease and behavioral-variant
frontotemporal dementia with disease severity
Akira Midorikawa (Hachioji-shi, Sydney/JP), Cristian Leyton, David Foxe, Ramon
Landin-Romero, John Hodges, Olivier Piguet (Sydney/AU)
P98
Clinical Differentiation of Psychiatric Disorders from Behavioural Variant
Frontotemporal Dementia: A prospective study
Everard Vijverberg (Amsterdam, The Hague/NL), Flora Gossink, Welmoed Krudop,
Sietske Sikkes, Cora Kerssens, Niels Prins, Max Stek, Philip Scheltens, Yolande
Pijnenburg, Annemiek Dols (Amsterdam/NL)
P99
Music defines fMRI signatures of molecular nexopathies
Jennifer L Agustus, Camilla N Clark, Hannah L Golden, Catherine F Slattery, Phillip
D Fletcher, Jonathan D Rohrer, Jason D Warren (London/GB)
P100
Do criteria for behavioural variant frontotemporal dementia capture the cognitive and
behavioural profile of ALS/FTD?
Jennifer Adams, Jennifer Thompson, Matthew Jones, Jennifer Harris, Anna
Richardson, Tobias Langheinrich, David Neary, Julie Snowden (Salford/GB)
P101
Progression in late onset frontal lobe syndrome
Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek,
Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)
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ICFTD 2016
P102
Body schema processing in frontotemporal dementia
Rebecca Bond, Christopher Hardy, Lucy Russell, Charles Marshall, Camilla Clark,
Sebastian Crutch, Jonathan Rohrer, Jason Warren (London/GB)
P103
Vascular Frontotemporal Disorder
Michael Hoffmann, Fabian Rossi, Ramon Rodriguez Cruz, Annuli Khaki, Khizar Malik
(Orlando, Florida, Orlando/US)
P104
Risk of suicide in patients with behavioral variant Frontotemporal Dementia
Innocenzo Rainero, Milena Zucca, Elisa Rubino, Flora Govone, Alessandro Vacca,
Lorenzo Pinessi (Turin/IT)
P105
Moral processing deficit in behavioral variant frontotemporal dementia is associated
with emotion recognition deficits and both structural and functional lateral orbitofrontal
abnormalities
Jan Van den Stock, François-Laurent De Winter, Dante Mantini, Jan Jastorff, Rik
Vandenberghe, Mathieu Vandenbulcke (Leuven/BE)
P106
Demographic influence in Depression prevalence in frontotemporal dementia (FTD):
A meta-regression perspective
Amir Sepehry, Anita Afshinkia, Ging-Yuek Robin Hsiung (Vancouver/CA)
P107
Boxer’s Dementia with Aggression and Sexual Disinhibition - A Case Series
Viviana Chiappetta, Mohamed Eldefrawi, Sasidhar Gunturu, Monica Babillo, Marlene
Carrillo, Elba Contreras (Bronx/US)
P108
Psychotic symptoms and formal thought disorders in behavioral variant
Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek,
Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)
P109
Profile of Memory impairment in behavioral variant of the FTD
Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero,
Diana Lucía Matallana Eslava (Bogotá/CO)
P110
Semantic categorization into the variants of FTD
Cristian Triviño Martínez, Milena García García, Hernando Santamaría-García, Diana
Lucía Matallana Eslava (Bogotá/CO)
P111
A longitudinal study of neuropsychiatric and cognitive symptoms in patients with
FTDbv
Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero,
Diana Lucía Matallana Eslava (Bogotá/CO)
P112
Differences in social cognition between behavioral-variant frontotemporal dementia
and depression: preliminary results
Maya Lichtenstein, Nader Fallah, Andrew Howard (Vancouver/CA), Paul Eslinger
(Hershey/US), Howard Feldman (Vancouver, San Diego/US)
P113
Behavioral variant frontotemporal dementia mimicked by right carotid artery stenosis
without observable lesion on MRI.
Yong Bum Kim, Pil-Wook Chung, Heui-Soo Moon, Bum Chun Suh, Won Tae Yoon
(Seoul/KR)
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ICFTD 2016
P114
Neuropsychological Assessment of Medial Frontal Functioning in Frontotemporal
Dementia
Julia MacKinley, Mervin Blair, Kristy Coleman, Sascha Gill, Dhwanil Bhatty
(London/CA), Erin Warriner, Kathy Smolewska (Hamilton/CA), Stephen Pasternak
(London/CA), Mavis Kershaw (Victoria/AU), Elizabeth Finger (London/CA)
P115
Neural Correlates of Reversal Learning Deficits in Behavioral Variant Frontotemporal
Degeneration
Kylie Ternes, Joseph Kable (Philadelphia/US), Joseph McGuire (Boston/US), Katya
Rascovsky, Corey McMillan, Murray Grossman (Philadelphia/US)
P116
Compulsory mental care among patients with a neuropathologically confirmed
dementing disorder
Madeleine Liljegren, Maria Landqvist Waldö, Robert Rydbeck, Elisabet Englund
(Lund/SE)
P117
Qualitative assessment of verbal fluency performance in patients with bvFTD and
PPA
Esther van den Berg, Lize Jiskoot, Marielle Grosveld, John van Swieten
(Rotterdam/NL)
P118
Similar Findings on Clinical and Neuropsychological Measures in Asymptomatic
Mutation Versus Non-Mutation Carriers: Preliminary Data From LEFFTDS
Brad Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US),
Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Brad
Dickerson (Boston/US), Kelley Faber (Indianapolis/US), Julie Fields (Rochester/US),
Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal
(St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US),
Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao
(Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David
Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San
Francisco/US), David Knopman (Rochester/US), John Kornak, Joel Kramer (San
Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce
Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers
(Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw
(Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los
Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US),
Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)
P119
Differences on Neuropsychiatric Measures in Asymptomatic (CDR=0) Versus Mildly
Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS
Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Adam Boxer (San
Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US),
Bradford Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields
(Rochester/US), Tatiana Faroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),
Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford
(Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San
Francisco/US), John Hsiao (Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA),
Edward D. Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci
(Rochester/US), Anna Karydas (San Francisco/US), David Knopman
(Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter Kukull
(Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US),
Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine
Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland
(Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US),
11
ICFTD 2016
Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek
(Jacksonville/US)
P120
Investigating the role of face processing in behavioural variant frontotemporal
dementia
Lucy Russell, Martina Bocchetta, Sophie Harding, Sebastian Crutch, Jason Warren,
Jonathan Rohrer (London/GB)
P121
Neuropsychological profiles in familial frontotemporal dementia
Sophie Leijdesdorff, Esther van den Berg, Lize Jiskoot, Janne Papma, John van
Swieten (Rotterdam/NL)
P122
Longitudinal analysis of cognitive test score trajectories in behavior variant
P123
Social behavioral changes differ in frontotemporal dementia and semantic dementia
Harmony DUCLOS, Serges BELLIARD, Catherine MERCK, Vincent DE LA
SAYETTE, Francis EUSTACHE, Beatrice DESGRANGES, Mickaël LAISNEY
(Caen/FR)
P124
Longitudinal analysis of electronic messages to characterize language decline in
frontotemporal dementia with bulbar amyotrophic lateral sclerosis
Kalyani Kansal, Elsheba Abraham, Ashnaa Rao, Chiadi Onyike (Baltimore/US)
P125
Longitudinal performance of global measures of illness severity in semantic dementia
P126
Neuropsychiatric Symptoms in the Genetic Frontotemporal Dementia Initiative
(GENFI) Cohort
Leila Sellami (Québec/CA), Martina Bocchetta (London, United Kingdom/GB), John
van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti
(Milan/IT), Mario Masellis (Toronto/CA), James B Rowe (Cambridge/GB), Caroline
Graff (Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT),
Elizabeth Finger (London Ontario/CA), Alexandre Mendonça (Lisboa/PT), Sandro
Sorbi (Florence/IT), Katrina M Dick, Jonathan D Rohrer (London/GB), Robert Laforce
Jr (Québec/CA)
P127
Differences on Neuropsychological Measures in Asymptomatic (CDR=0) Versus
Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS
Joel Kramer (San Francisco/US), Sandra Weintraub (Chicago/US), Brad Boeve
(Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola
(Los Angeles/US), Christina Dheel (Rochester/US), Brad Dickerson (Boston/US),
Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tationa Faroud
(Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US),
Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray
Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao
(Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David
Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San
Francisco/US), David Knopman (Rochester/US), John Kornak (San Francisco/US),
Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San
Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers
Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US),
Zbigniew Wszolek (Jacksonville/US)
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ICFTD 2016
P128
Depressive symptoms in patients with frontotemporal lobar degeneration
Mamoru Hashimoto, Ryuji Fukuhara, Keiichiro Kaneda, Manabu Ikeda
(Kumamoto/JP)
P129
Virtual reality as an assessment of cognition in behavioural variant Frontotemporal
Dementia: A Feasibility Study.
Emilie Brotherhood, Jason Drummond, David Swapp, Lucy Russell, Silvia Primativo,
Chris Hardy, Anthony Steed, Mel Slater, Jonathan D. Rohrer, Jason Warren,
Sebastian Crutch (London, UK/GB)
P130
Mistakes, I’ve made a few: Intact awareness, but impaired emotional processing of
errors in bvFTD.
Howard Rosen, Carole Scherllng (San Francisco/US), Jessica Zakrzewski (San
Francisco, Gainsville/US), Samir Datta (San Francisco/US), Robert Levenson
(Berkeley/US), Virginia Sturm, Bruce Miller (San Francisco/US)
P131
Misdiagnosis of very early frontotemporal dementia
Florindo Stella (Rio Claro-SP, Brazil, São Paulo - Brazil, Campinas-SP, Brazil/BR),
Lucas Mella, Vítor Marques, Thiago Fontana (Campinas-SP, Brazil/BR), Júlia
Loureiro (São Paulo - Brazil, Campinas-SP, Brazil/BR), Luiz Silva (Campinas-SP,
Brazil/BR)
P132
CLINICAL AND NEUROCOGNITIVE CORRELATES UNDERLYING THE FIRST
SYMPTOMS IN BEHAVIORAL VARIANT OF FRONTO TEMPORAL DEMENTIA
(BVFTD)
Hernando Santamaría García (Bogotá, Buenos Aires/CO), Pablo Reyes
(Bogotá/CO), Sandra Báez (Buenos Aires/AR), Ángela Martínez, José Santacruz
(Bogotá/CO), Mariano Sigman (Buenos Aires/AR), Diana Matallana (Bogotá/CO),
Agustín Ibáñez (Buenos Aires/CO)
P133
Frontotemporal dementia and schizophrenia - whats the connection I? An updated
case series and review of the literature.
Dennis Velakoulis, Samantha Loi (Melbourne/AU)
P134
Neuronal correlates of theory of mind and emotion comprehension during insincere
communication in neurodegenerative disease
Gianina Toller, Tal Shany-Ur, Suzanne Shdo, Laura Bouvet, Clinton Mielke, Scott N.
Grossman, Pardis Poorzand, Bruce L. Miller, Katherine P. Rankin (San
Francisco/US)
P135
Intra-individual variability in cognitive measures as a differential marker of genetic
variant FTD: a neuropsychological perspective
Amir Sepehry, Dana Wittenberg, Pheth Sengdy, Penny Slack (Vancouver/CA), Matt
Baker, Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian Mackenzie, GingYuek Hsiung (Vancouver/CA)
P136
The Moral Emotions Assessment: a new tool for the early diagnosis of frontotemporal
dementia.
Chloe Daigmorte, Maeva Camus, Thomas Mauras, Aurélie Funkiewiez, Isabelle Le
Ber, Bruno Dubois, Richard Levy, Marc Teichmann, Carole Azuar (Paris/FR)
P137
ECOCAPTURE. A Quantitative Evaluation of Apathy Close to Real Life Situation by
Means of a Multimodal Sensor System Integrated.
Bénédicte BATRANCOURT, Karen LECOUTURIER, Carla ARAUJO (PARIS, F75013, Paris, France/FR), Vincent GUILLEMOT (F-75013, Paris, France/FR), Carole
AZUAR, Richard LEVY (PARIS, F-75013, Paris, France/FR)
13
ICFTD 2016
P138
Physical aggressiveness among patients with a neuropathologically confirmed
dementing disorder
Madeleine Liljegren, Maria Landqvist Waldö (Lund/SE), Alexander Frizell Santillo
(Malmö/SE), Elisabet Englund (Lund/SE)
P139
Neuropsychiatric symptoms in patients with Alzheimer's disease and frontotemporal
dementia. Why is it important the night time behaviors and anxiety in the clinical
presentation of the Frontolobar Degeneration dementia?
Adrian Martinez Ruiz, G. Isaac Acosta Castillo, Leonardo Ramirez, Ana Luisa Sosa
Ortiz (Mexico City/MX)
P140
Association between MoCA Subitem Scores and Corresponding Cognitive Test
Performance in Patients with bvFTD
Kristy Coleman (London/CA), Brenda Coleman (Toronto/CA), Julia MacKinley,
Stephen Pasternak, Elizabeth Finger (London/CA)
P141
The differences of characteristics in abnormal eating behaviors in semantic dementia
between right and left predominant temporal lobe atrophy
Ryuji Fukuhara, Mamoru Hashimoto (Kumamoto-city/JP), Shunichiro Shinagawa
(Tokyo/JP), Kazue Shigenobu (Osaka/JP), Hibiki Tanaka, Kazuhiro Kawahara,
Yusuke Miyagawa, Naoko Ichimi, Manabu Ikeda (Kumamoto-city/JP)
P142
Relationship between cognitive declines and independency in the activities of daily
living in patients with frontotemporal dementia.
Maki Hotta, Mamoru Hashimoto, Ryuji Fukuhara, Asuka Koyama, Miki Murata,
Kazuhiro Yoshiura, Tomohisa Ishikawa, Hibiki Tanaka, Manabu Ikeda
(Kumamoto/JP)
P143
Neurobiological Subtract of False-Belief Reasoning: Insights from Frontotemporal
Dementia and Alzheimer’s Disease
Belen Pascual, Sahil Bajaj, Joseph C Masdeu (Houston/US)
P144
Altered Fronto-Thalamic Functional Connectivity and its Association with Emotion
Recognition Deficits in Frontotemporal Dementia
Namita Multani, Cassandra Jessica Anor, David F. Tang-Wai, Ron Keren, Maria
Carmela Tartaglia (Toronto/CA)
P145
Frontal lobe dysfunction in early recovery period of ischemic stroke
Lyudmila Pustokhanova, Elena Morozova (Perm/RU)
P146
Longitudinal neuropsychological evaluation of progranulin (GRN) mutation carriers
Dana Wittenberg, Robin G.Y. Hsiung, Pheth Sengdy (Vancouver/CA), Matthew
Baker, Rosa Rademakers (Vancouver/US), Penny Slack, Howard H. Feldman, Ian R.
Mackenzie (Vancouver/CA)
P147
Cognitive and Behavioral Trajectory of Behavioral-Variant Frontotemporal Dementia
Differs According to Underlying Pathology
Jeffrey Phillips, David Irwin, Katya Rascovsky, Vivianna Van Deerlin, Virginia Lee,
John Trojanowski, Corey McMillan, Murray Grossman (Philadelphia/US)
P148
Variables affecting emotional reactivity to socioemotional stimuli in frontotemporal
dementia
Sylvia Fong, Mario F. Mendez (Los Angeles/US)
14
ICFTD 2016
P149
Patterns of neuropsychiatric symptoms in a Mexican sample diagnosed with
Alzheimer’s disease and frontotemporal dementia (behavioral and language variants)
according to stage of cognitive decline.
Juan Francisco Flores-Vazquez, Gilberto Isaac Acosta-Castillo, Airam CamposJiménez, Loreli Alvarez-Diaz, Adrian Martínez Ruiz, Ana Luisa Sosa-Ortiz (Mexico
City/MX)
P150
Differences on Novel Measures of Social Comportment in Asymptomatic (CDR=0)
Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From
LEFFTDS
Katherine Rankin, Joel Kramer, Howard Rosen (San Francisco/US), Brad Boeve
(Rochester/US), Adam Boxer (San Francisco/US), Giovanni Coppola (Los
Angeles/US), Brad Dickerson (Boston/US), Christina Dheel, Julie Fields, Ralitza
Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New
York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman
(Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US),
Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin
(Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas, John Kornak (San
Francisco/US), David Knopman (Rochester/US), Walter Kukull (Seattle/US), Ian
Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps
(Bethesda/US), Rosa Rademakers (Jacksonville/US), Les Shaw (Philadelphia/US),
Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John
Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Sandra Weintraub
(Chicago/US), Zbigniew Wszolek (Jacksonville/US)
P151
Greater facial expressive versus self-reported emotional reactivity correlates with
diminished right posterior insular volume in bvFTD
Peter Pressman (San Francisco, Berkeley/US), James J. Casey, Kuan Hua-Chen
(Berkeley/US), Clinton Mielke, Katherine Rankin (San Francisco/US), Robert W.
Levenson (Berkeley/US)
P152
Frontotemporal dementia and schizophrenia - whats the connection II? A
neuropsychological and social cognition comparison of patients with chronic
schizophrenia and FTD
Dennis Velakoulis, Hui-Minn Chan, Wendy Kelso, Rene Stalky (Melbourne/AU)
P153
The Attribution of Animacy and Agency in Frontotemporal Dementia vs. Alzheimer’s
Disease
Sylvia S Fong, Andrew R Carr, Madelaine Daianu (Los Angeles/US), Mariel B
Deutsch (Los Angeles, New York/US), Elvira E Jimenez, Kevin O Juarez, Michelle M
Mather (Los Angeles/US), Pongsatorn P Paholpak (Los Angeles, Khon Khaen/TH),
Sean E Perfecto, Paul M Thompson, Mario F. Mendez (Los Angeles/US)
P154
Social emotions in behavioral variant frontotemporal (bvFTD) patients. How FTD
patients experience schadenfreude and envy.
Hernando Santamaría García (Bogotá, Buenos Aires/CO), Sandra Baez (Bogotá,
Buenos Aires/AR), Pablo Reyes, Diana Matallana (Bogotá/CO), Agustín Ibáñez
(Buenos Aires/CO)
P155
Cross-cultural Adaptation and Validity of the Brazilian version of the Clinical staging
scale and disease progression in frontotemporal dementia
Thaís Bento Lima da Silva, Valéria Bahia, Mário Amore Cecchini, Luciana Cassimiro,
Viviane Amaral Carvalho, Henrique Cerqueira Guimarães, Paulo Caramelli, Marcio
Balthazar, Benito Damasceno, Cássio Bottino, Sonia Brucki, Leonardo Cruz de
Souza (SAO PAULO/BR), Eneida Mioshi (SAO PAULO/GB), Ricardo Nitrini, Mônica
Yassuda (SAO PAULO/BR)
15
ICFTD 2016
P156
Distinct Patterns of Cognitive Behavioral Change in Emerging FTLD in the Presence
and Absence of MND Support a ‘Bottom-Up’ Model of FTLD Onset.
Claire Flaherty (Hershey/US)
17:30–19:00
Room
Chairs
Session 3: Genetics of FTLD
Lecture Hall
Peter Heutink (Tuebingen/DE), Christine van Broeckhoven (Antwerp/BE)
17:30
Next generation sequencing approaches in FTD and ALS
Stefan Züchner (Miami, FL/US)
17:55
O5
Identification Of A Novel FTD-MND Gene On Chromosome 16
Carol Dobson-Stone, Agnes Luty (Sydney/AU), Elizabeth Thompson, Peter
Blumbergs (Adelaide/AU), William Brooks, Claire Shepherd (Sydney/AU), Justin
Yerbury (Wollongong/AU), Glenda Halliday, Peter Schofield, John Kwok (Sydney/AU)
18:10
Global initiative to identify genetic modifiers of disease onset and presentation in
patients with progranulin mutations
Cyril Pottier (Jacksonvile/US), Daniel J Serie (Jacksonville/US), Edward D Huey
(New York/US), Manuela Neumann (Tuebingen/DE), Peter Johannsen
(Copenhagen/DK), Jarosław Slawek (Gdańsk/PL), Elizabeth C Finger (London
Ontario/CA), Carol F Lippa (Philadelphia/US), Charles L III White (Dallas/US),
Thomas G Beach (Sun City/US), John B Kwok (Sydney/AU), Sandro Sorbi
(Florence/IT), Bernardino Ghetti (Indianapolis/US), Marsel M Mesulam, Elieen H
Bigio (Chicago/US), Raquel Sanchez-valle (Barcelona/ES), Stuart Pickering-Brown
(Manchester/GB), Amalia Bruni (Lamezia terme/IT), Ekaterina Rogaeva
(Toronto/CA), Jonathan D Rohrer (London/GB), Caroline Graff (Stockholm/SE), Ian R
Mackenzie (Vancouver/CA), Thomas D Bird (Seattle/US), Carlos Cruchaga (Saint
Louis/US), John C van Swieten (Rotterdam/NL), Bruce L Miller (San Francisco/US),
Adolfo Lopez de Munain (San Sebastián/ES), Vivianna M Van Deerlin
(Philadelphia/US), Giacomina Rossi (Milan/IT), Luisa Benussi, Barbara Borroni
(Brescia/IT), Daniela Galimberti (Milan/IT), Roberta Ghidoni (Brescia/IT), Isabelle Le
Ber (Paris/FR), Joanna Biernacka (Rochester/US), Dennis W Dickson
(Jacksonvile/US), Neill R Graff-Radford (Jacksonville/US), Brad F Boeve
(Rochester/US), Rosa Rademakers (Jacksonvile/US)
O6
18:25
DB7
18:27
DB8
Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and
Frontotemporal dementia: a novel pathway in neurodegeneration
Rita Cacace (Antwerp/BE), Tobi Van den Bossche (Antwerp, Edegem/BE), Jonathan
Lippiat (Leeds/GB), Jonathan Janssens (Antwerp/BE), Greet De Baets (Leuven/BE),
Sebastiaan Engelborghs, Anne Sieben (Antwerp/BE), Mathieu Vandenbulcke
(Leuven/BE), Peter de Rijk, Elise Cuyvers, Caroline Van Cauwenberghe, Caroline
Robberecht, Lubina Dillen, Céline Merlin, Nathalie Geerts (Antwerp/BE), Rik
Vandenberghe (Leuven/BE), Jean-Jacques Martin, Peter P. De Deyn (Antwerp/BE),
Joost Schymkowitz (Leuven/BE), Stuart Maudsley, Marc Cruts, Julie van der Zee,
Kristel Sleegers, Christine Van Broeckhoven (Antwerp/BE)
Symptom Onset in Genetic Frontotemporal Dementia
Katrina M Dick (London/GB), Bradley F Boeve (Minnesota, USA/US), Barbara
Borroni (Brescia, Italy/IT), Adam Boxer (San Francisco, California/US), Alexis Brice
(Paris, France/FR), Christopher R Butler (Oxford, UK/GB), Philippe Couratier
(Limoges, France/FR), Bradford C Dickerson (Charlestown, MA, USA/US), Simon
Ducharme (QC, Canada/CA), Elizabeth Finger (London, ON, Canada/CA), Daniela
Galimberti (Milan, Italy/IT), Alexander Gerhard (Manchester, UK/GB), Nupur Ghoshal
16
ICFTD 2016
(MO, USA/US), Caroline Graff, (Stockholm, Sweden/SE), Murray Grossman,
(Philadelphia, PA 19104, USA/US), John R Hodges, (Sydney, Australia/AU), Edward
D Huey (New York, USA/US), Robert Laforce Jr (QC, Canada/CA), Isabelle Le Ber
(Paris, France/FR), Johannes Levin (Munich, Germany/DE), Ian R Mackenzie
(Canada/CA), Mario Masellis (Toronto Canada/CA), Olivier Martinaud (France/FR),
Alexandre Mendonça, (Lisbon, Portugal/PT), Fermin Moreno (San Sebastián,
Spain/ES), Jennifer M Nicholas, (London, London, UK/GB), Chiadi U Onyike (MD,
USA/US), Markus Otto (Ulm, Germany/DE), Erik D Roberson (USA/US), Emily
Rogalski (United States/US), Howard J Rosen (San Francisco, California/US), James
B Rowe (Cambridge, UK/GB), Raquel Sanchez-Valle (Barcelona, Spain/ES), Isabelle
Santana (Coimbra, Portugal/PT), Sandro Sorbi (Florence, Italy/IT), John van Swieten
(Rotterdam, Netherlands/NL), Matthis Synofzik (Tuebingen, Germany/DE), Fabrizio
Tagliavini (Milano, Italy/IT), Rik Vandenberghe (Leuven, Belgium/BE), Jonathan D
Roher (London/GB)
18:29
DB9
18:31
DB10
ATXN2 polyQ intermediate repeats influence Frontotemporal Lobar Degeneration
phenotype
Elisa Rubino, Cecilia Mancini, Patrizia Ferrero, Marina Ferrone, Stefano Bianca,
Silvia Boschi, Milena Zucca, Laura Orsi, Salvatore Gentile, Lorenzo Pinessi, Alfredo
Brusco, Innocenzo Rainero (Turin/IT)
Gene-based analysis detects novel loci associated with frontotemporal dementia and
its clinical subtypes
Aniket Mishra (Amsterdam/NL), Raffaele Ferrari, FTD-GWAS Consortium (London,
UK/GB), Peter Heutink (Tuebingen/DE), John Hardy (London, UK/GB), Yolande
Pijnenburg, Danielle Posthuma (Amsterdam/NL)
18:35
Panel discussion: How do we move from large scale sequencing efforts in genetics to
biology?
Peter Heutink (Tuebingen/DE)
19:30–21:00
Room
Welcome reception
Foyer
17
ICFTD 2016
Program September 1, 2016
08:30–10:00
Room
Chairs
Session 4: Molecular neuropathology of FTLD
Lecture Hall
Manuela Neumann (Tuebingen/DE), Ian Mackenzie (Vancouver/CA)
08:30
Molecular neuropathology of FTLD with focus on C9orf72 mutations
Ian Mackenzie (Vancouver/CA)
08:55
Evidence from human studies for spreading/staging of TDP-43 pathology in FTLD
and ALS
Glenda Halliday (Sydney/AU)
09:20
New Models For Alzheimer's And other Related Tauopathies By Transmission Of
Neuronal And Glial Tau Pathology
John Trojanowski (Philadelphia/US)
O7
09:35
O8
Clinicopathological correlations in early vs. late age-of-onset frontotemporal dementia
and frontotemporal lobar degeneration
Sang Won Seo, Marie-Pierre Thibodeau, David C. Perry, Alice Hua, Manu Sidhu,
Stephanie E. Gaus, Gil Rabinovici, Katherine D. Rankin, Adam L. Boxer, Joel H.
Kramer, Howard J. Rosen, Maria Luisa Gorno-Tempini, Lea T. Grinberg, Eric J.
Huang, Stephen J. DeArmond, John Q. Trojanowski, Bruce L. Miller, William W.
Seeley (San Francisco/US)
09:50
DB11
TTBK1/2 hyper-activation drives pTau and pTDP accumulation
Laura Taylor, Pam McMillan, Nicole Liachko, Aleen Saxton, Tim Strovas, Brian
Kraemer (Seattle/US)
09:52
Cerebrospinal fluid phosphorylated tau levels are associated with post-mortem tau
inclusion burden in frontotemporal lobar degeneration
David Irwin (Philadelphia/US), Alberto Lleo (Barcelona/ES), Corey McMillan, Felicia
Cooper, David Wolk, Leslie Shaw, Edward Lee, John Trojanowski, Murray Grossman
(Philadelphia/US)
DB12
09:54
DB13
Testing reversibility of pathology in a new in vitro model for C9orf72 ALS/FTD
Frederike Riemslagh, Renate Hukema, Santoesha Nanhoe, Charlene den Hollander,
Helen de Boer, John van Swieten, Rob Willemsen (Rotterdam/NL)
09:56
Abundant lower motor neuron RNA foci with perinucleolar studding in C9orf72 FTDALS
Sarat Vatsavayai, Stephanie Gaus, Ji-Hye Hwang, Bruce Miller, William Seeley (San
Francisco/US)
DB14
10:30–12:00
Room
Chairs
Session 5: Progressive aphasias
Lecture Hall
Marilu Gorno-Tempini (San Francisco, CA/US), Peter Nestor (Magdeburg/DE)
10:30
Apraxia of speech and its rehabilitation
Maya Henry (Austin, TX/US)
10:55
The right hemisphere and its semantics
Peter Garrard (London/GB)
18
ICFTD 2016
11:20
O9
In vivo correlates of pathological diagnosis in clinical variants of primary progressive
aphasia
Edoardo Gioele Spinelli (Milan, San Francisco/IT), Maria Luisa Mandelli, Miguel
Santos (San Francisco/US), Stephen M Wilson (Tucson/US), Federica Agosta
(Milan/IT), John Q Trojanowski (Philadelphia/US), Eric J Huang, Lea T Grinberg (San
Francisco/US), Massimo Filippi (Milan/IT), Bruce L Miller, William W Seeley, Maria
Luisa Gorno-Tempini (San Francisco/US)
11:35
O10
Imaging tDCS effects in primary progressive aphasia
Kyrana Tsapkini, Yenny Webb-Vargas, Andreia Faria, Bronte Ficek, Tushar
Chakravarty, Constantine Frangakis, John Desmond, Martin Lindquist, Argye Hillis
(Baltimore/US)
11:50
Bilingualism in primary progressive aphasia: systematic review and case reports from
two European centers
Ana Sofia Costa (Braga/PT), Jennifer Wojtala (Aachen/DE), Sofia Rocha (Braga/PT),
Kathrin Reetz (Aachen/DE), Alvaro Machado (Braga/PT)
DB15
11:52
DB16
Differential binding of AV-1451 tau-PET across variants of primary progressive
aphasia
Jennifer Whitwell, Nirubol Tosakulwong, Joseph Duffy, Heather Clark, Mary
Machulda, Edythe Strand, Matthew Senjem, Ronald Petersen, Clifford Jack, Val
Lowe, Keith Josephs (Rochester/US)
11:54
DB17
Deficits in Rhythm Processing in PPA are linked to SMA atrophy
Jolien Schaeverbeke, Rose Bruffaerts (Leuven/BE), Manon Grube (Berlin,
Newcastle-upon-Tyne/GB), Veerle Neyens (Leuven/BE), Bruno Bergmans
(Brugge/BE), Eva Dries (Leuven/BE), Tim Griffiths (Newcastle-upon-Tyne/GB), Rik
Vandenberghe (Leuven/BE)
11:56
Anatomo-functional segregation of the mental lexicon: the model of Primary
Progressive Aphasia
Clara Sanches, Marc Teichmann, Olivier Colliot (Paris/FR), Alexandre Routier
(Paris/FI), Rafaella Miggliaccio (Paris/FR)
DB18
12:00–14:00
Room
Postersession II - Genetics
Ballroom
P157
C9orf72, does the size matter?
Clemence Fournier, Vincent Anquetil, Agnès Camuzat, Mathieu Barbier (PARIS/FR),
Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant, Florence Pasquier
(Lille/FR), GIE NeuroCEB Network (Paris/FR), Bruno Dubois, Charles Duyckaerts
(PARIS, Paris/FR), Alexis Brice (PARIS/FR), Isabelle Le Ber (PARIS, Paris/FR)
P158
RNA metabolism in Frontotemporal dementia.
Vincent Anquetil, Agnès Camuzat, Clemence Fournier, Pierre de la Grange, Mathieu
Barbier (Paris/FR), Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant,
Florence Pasquier (Lille/FR), Bruno Dubois, Véronique Sazdovitch, Danielle Seilhean
(Paris/FR), Luc Buée (Lille/FR), Alexis Brice, Charles Duyckaerts, Isabelle Le Ber
(Paris/FR)
19
ICFTD 2016
P159
A cluster of progranulin C157KfsX97 mutations in Southern Italy: clinical
characterisation and genetic correlations
Dario Saracino, Cinzia Coppola, Gianfranco Puoti, Giacomo Lus, Clemente Dato
(Naples/IT), Isabelle Le Ber (Paris/FR), Paola Caroppo, Elena Piccoli, Fabrizio
Tagliavini (Milan/IT), Giuseppe Di Iorio (Naples/IT), Giacomina Rossi (Milan/IT)
P160
Genetic screening of C9orf72 and TBK1 mutations and clinical correlations in
combined FTLD/ ALS phenotypes
Estrella Gómez-Tortosa, María Ruggiero (Madrid/ES), Emilio Franco-Macías
(Seville/ES), Cristina Prieto-Jurczynska, Begoña Venegas, Carlos Ordás, Silvia Gil
Navarro, Rosa Guerrero, Julián Pérez-Pérez, Mª José Sainz (Madrid/ES)
P161
TBK1 mutation frequencies and associated phenotypes in French frontotemporal
dementia and amyotrophic lateral sclerosis cohorts
Agnes Camuzat, Paola Caroppo, Anne De Septenville, Stephanie Millecamps
(PARIS/FR), Philippe Couratier (LIMOGES/FR), Mathieu Barbier (PARIS/FR),
Frederic Blanc (STRASBOURG/FR), Lucette Lacomblez (PARIS/FR), François
Sellal, Marie-Celine Fleury (STRASBOURG/FR), Alexis Brice, Isabelle Le Ber
(PARIS/FR), French Clinical and Genetic Research Network on FT French Clinical
and Genetic Research Network on FT (France/FR)
P162
Clinical features of TBK1 carriers and comparison with Belgian FTD patients carrying
another FTD-TDP causing mutation.
Sara Van Mossevelde (Antwerp, Wilrijk, Edegem/BE), Julie van der Zee, Ilse
Gijselinck (Antwerp, Wilrijk/BE), Sebastiaan Engelborghs (Wilrijk, Antwerp/BE), Anne
Sieben (Antwerp, Wilrijk, Ghent/BE), Tim Van Langenhove (Antwerp, Wilrijk,
Edegem/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets (Antwerp, Wilrijk,
Edegem/BE), Mathieu Vandenbulcke, Koen Van Laere (Leuven/BE), Sarah
Ceyssens (Antwerp, Edegem/BE), Marleen Van den Broeck, Karin Peeters, Maria
Mattheijssens (Antwerp, Wilrijk/BE), Patrick Cras (Wilrijk, Edegem/BE), Rik
Vandenberghe (Leuven/BE), Peter De Jonghe (Antwerp, Wilrijk, Edegem/BE), JeanJacques Martin (Wilrijk/BE), Peter P. De Deyn (Wilrijk, Antwerp/BE), Marc Cruts,
Christine Van Broeckhoven (Antwerp, Wilrijk/BE)
P163
TBK1 loss-of function and dominant-negative mutations in an extended European
cohort of FTD and ALS patients.
Julie van der Zee, Ilse Gijselinck, Sara Van Mossevelde, Federica Perrone,
Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets
(Antwerp/BE), Ellen Gelpi (Barcelona/BE), Ricardo Rojas-García (Barcelona/ES),
Jordi Clarimón, Alberto Lleó (Barcelona, Madrid/ES), Janine Diehl-Schmid,
Panagiotis Alexopoulos (Munchen/DE), Robert Perneczky (Munchen, London/DE),
Matthis Synofzik, Jennifer Just, Ludger Schöls (Tuebingen/DE), Caroline Graff,
Håkan Thonberg (Stockholm/SE), Barbara Borroni, Alessandro Padovani
(Brescia/IT), Albena Jordanova (Antwerp, Sofia/BE), Stayko Sarafov, Ivailo Tournev
(Sofia/BG), Alexandre de Mendonça, Gabriel Miltenberger-Miltényi, Frederico Simões
do Couto (Lisbon/PT), Alfredo Ramirez (Bonn/DE), Frank Jessen (Bonn,
Cologne/DE), Michael T. Heneka (Bonn/DE), Estrella Gómez-Tortosa (Madrid/ES),
Adrian Danek (Munich/DE), Patrick Cras (Antwerp/BE), Rik Vandenberghe
(Leuven/BE), Peter De Jonghe, Peter P. De Deyn, Kristel Sleegers, Marc Cruts,
Christine Van Broeckhoven, BELNEU consortium, EUEOD consortium
(Antwerp/BE)
P164
Large-scale Whole Genome Sequencing in ALS: Project MinE
Michael van Es (Utrecht/NL)
20
ICFTD 2016
P165
Investigating the genetic impact of TUBA4A in a Belgian cohort of FTD and ALS
patients
Federica Perrone, Hung Nguyen Phuoc, Sara Van Mossevelde (Antwerp/BE), Anne
Sieben (Antwerp, Ghent/BE), Jan De Bleecker (Ghent/BE), Mathieu Vandenbulcke,
Rik Vandenberghe (Leuven/BE), Sebastiaan Engelborghs, Jonathan Baets, Peter De
Jonghe, Patrick Cras, Peter De Deyn, Jean-Jacques Martin, Julie van der Zee,
Christine Van Broeckhoven (Antwerp/BE)
P166
Investigating the role of rare heterozygous CHCHD10 variants in a Belgian cohort of
FTD and ALS patients
Hung Nguyen Phuoc, Federica Perrone, Sara Van Mossevelde (Antwerp/BE), Anne
Sieben (Antwerp, Ghent/BE), Patrick Santens, Jan De Bleecker (Ghent/BE), Rik
Vandenberghe, Mathieu Vandenbulcke (Leuven/BE), Sebastiaan Engelborghs,
Jonathan Baets, Peter De Jonghe, Patrick Cras, Peter De Deyn, Jean Jacques
Martin, Julie Van Der Zee, Christine Van Broeckhoven (Antwerp/BE)
P167
Founder effect of P301L MAPT mutation in families with FTD in Baix Llobregat
County (Barcelona, Spain)
Leire Palencia-Madrid (Vitoria/ES), Sergi Borrego, Oriol Grau-Rivera, Ramon Reñe,
Isabel Hernandez (Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat,
Barcelona/ES), Anna Antonell, Mircea Balasa, Albert Llado (Barcelona/ES), Ellen
Gelpi (Barcelona/BE), Marian M. de Pancorbo (Vitoria/ES), Raquel Sanchez-Valle
(Barcelona/ES)
P168
ANALYSIS OF GENETIC POLIMORPHISMS AND GENETIC MUTATIONS IN
FRONTOTEMPORAL LOBAR DEGENERATION
María José Gil Moreno (Torrejón de Ardoz, Madrid/ES), María Sagrario Manzano
Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Miguel Calero Lara, Alberto
Rábano Gutiérrez (Madrid/ES)
P169
Impaired LTP-like cortical plasticity and intra-cortical facilitation in presymptomatic
FTLD mutation carriers.
Alberto Benussi, Maura Cosseddu, Ilaria Filareto, Valentina Dell'Era, Silvana Archetti,
Maria Sofia Cotelli (Brescia/IT), Anna Micheli (Bergamo/IT), Alessandro Padovani,
Barbara Borroni (Brescia/IT)
P170
Frontotemporal lobar degeneration spectrum: the first genetic screen in a Greek
cohort
Suzee Lee (San Francisco/US), Eliana Marisa Ramos (Los Angeles/US), Christos
Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing Wang,
Deepika Dokuru, Mochtar Pribadi (Los Angeles/US), Anastasios Bonakis, Vasiliki
Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce Miller (San
Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los Angeles/US),
Sokratis G. Papageorgiou (Athens/US)
P171
More than two-hundred and fifty FTD patients looking for genes: results from Italian
FTD Network
Antonella Alberici (Brescia/IT), Benedetta Nacmias (Florence/IT), Giancarlo
Logroscino (Lecce/IT), Amalia Bruni (Lamezia Terme, Catanzaro/IT), Fabrizio
Tagliavini (Milan/IT), Roberta Ghidoni (Brescia/IT), Daniela Galimberti (Milan/IT),
Laura Bonanni (Chieti/IT), Annachiara Cagnin (Padua/IT), Marco Bozzali (Rome/IT),
Vincenzo Silani (Milan/IT), Rosanna Turrone (Brescia/IT), Camilla Ferrari, Gemma
Lombardi, Valentina Bessi (Florence/IT), Rosa Capozzo, Chiara Zecca, Simone
Arcuti (Lecce/IT), Chiara Cupidi, Livia Bernardi, Nicoletta Smirne, Francesca
Frangipane (Lamezia Terme, Catanzaro/IT), Giacomina Rossi, Paola Caroppo, Pietro
Tiraboschi (Milan/IT), Luisa Benussi, Giuliano Binetti, Miriam Ciani, Silvia Fostinelli
21
ICFTD 2016
(Brescia/IT), Andrea Arighi, Chiara Fenoglio, Giorgio Fumagalli (Milan/IT), Marco
Onofrj (Chieti/IT), Elio Scarpini (Milan/IT), Sandro Sorbi (Florence/IT), Alessandro
Padovani, Barbara Borroni (Brescia/IT)
P173
TREM2 variant p.His157Tyr in Colombian patients with frontotemporal dementia.
Andrea Lopez-Caceres, Andres Laserna (Bogotá/CO), Cristian Triviño-Martínez,
Elkin Garcia-Cifuentes (Bogota/CO), Juan Carlos Gómez-Vega, Paola AyalaRamírez (Bogotá/CO), Pablo Reyes, Hernando Santamaría-García, Jose Manuel
Santacruz (Bogota/CO), Ignacio Zarante (Bogotá/CO), Diana Matallana (Bogota/CO)
P174
Utilizing FTD-associated MAPT-S305 mutations to develop cell models that express
4R Tau
Kathryn Bowles, Alison Goate (New York/US)
P175
Unraveling the genetic role of SORT1 in the Belgian frontotemporal dementia
population
Stephanie Philtjens, Eline Wauters, Sara Van Mossevelde, Julie van der Zee, Tim
Van Langenhove, Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke
(Leuven/BE), Maarten Versteven, Karin Peeters, Maria Mattheijssens, Marleen Van
den Broeck, Patrick Cras (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Peter P. De
Deyn, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)
P176
Differences in rate of participation in clinical research studies in asymptomatic
members of families with frontotemporal dementia (FTD)
Ging-Yuek R. Hsiung, Pheth Sengdy, Emily Dwosh (Vancouver/CA), Matt Baker,
Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian R. Mackenzie
(Vancouver/CA)
P177
Right temporal variant frontotemporal dementia with motor neuron disease: a novel
association with the C9orf72 expansion
Ione Woollacott, Katrina Dick, Elizabeth Gordon, Martina Bocchetta, Sophie Harding,
Katie Sidle, Jason Warren, Jonathan Rohrer (London/GB)
P178
VALIDATION OF FRONTOTEMPORAL LOBAR DEGENERATION PEDIGREE
CLASSIFICATION CRITERIA IN A NORTHERN ITALY COHORT: IMPLICATIONS
FOR GENETIC TESTING AND COUNSELING
LUISA BENUSSI, SILVIA FOSTINELLI, MIRIAM CIANI, ROBERTA ZANARDINI,
GIULIANO BINETTI, ROBERTA GHIDONI (BRESCIA/IT)
P179
Molecular mechanism of genetic anticipation in C9orf72 repeat expansion families
Marc Cruts, Ilse Gijselinck, Sara Van Mossevelde, Julie van der Zee, Anne Sieben,
Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Adrian Ivanoiu
(Brussels/BE), Olivier Deryck (Bruges/BE), Bavo Heeman, Veerle Bäumer, Marleen
Van den Broeck, Maria Mattheijssens, Karin Peeters (Antwerp/BE), Peter De Jonghe,
Patrick Cras (Antwerp, Edegem/BE), Jean-Jaques Martin, Peter Paul De Deyn,
Christine Van Broeckhoven (Antwerp/BE)
P180
The genetic landscape of clinical FTD: a systematic whole-exome sequencing study
of 125 consecutive cases
Cornelis Blauwendraat, Carlo Wilke, Iris Jansen, Patrizia Rizzu, Javier SimónSánchez, Peter Heutink, Matthis Synofzik (Tuebingen/DE)
P181
Myelin Oligodendrocyte Basic Protein and Longitudinal Decline in Behavioral-Variant
Lauren Massimo, Lior Rennert, Sharon Xie, Vivianna Van Deerlin, David Irwin, Corey
McMillan, Murray Grossman (Philadelphia/US)
22
ICFTD 2016
P182
Genetic overlap between 4-repeat tauopathies suggests a role for development in the
pathobiology of corticobasal degeneration
Jennifer Yokoyama (San Francisco/US), Chun Fan (San Diego/US), Yunpeng Wang
(Oslo/NO), Naomi Kouri (Jacksonville/US), Raffaele Ferrari (London/GB), Ole
Andreassen (Oslo/NO), John Hardy (London/GB), Adam Boxer, Bruce Miller (San
Francisco/US), Gerard Schellenberg (Philadelphia/US), Dennis Dickson
(Jacksonville/US), Anders Dale (San Diego/US), Rahul Desikan (San Francisco/US)
P183
Effects of multiple genetic loci on age at onset in frontotemporal dementia
Raffaele Ferrari (London/GB), M Grassi, F Graziano, F Palluzzi (Pavia/IT), S Archetti,
E Bonomi (Brescia/IT), AC Bruni, RG Maletta, L Bernardi, C Cupidi, R Colao
(Lamezia Terme/IT), I Rainero, E Rubino, L Pinessi (Torino/IT), D Galimberti, E
Scarpini, M Serpente (Milan/IT), B Nacmias, I Piaceri, S Bagnoli (Florence/IT), G
Rossi (Florence, Milan/IT), G Giaccone, F Tagliavini (Milan/IT), L Benussi, G Binetti,
R Ghidoni (Brescia/IT), A Singleton (Bethesda/US), J Hardy, P Momeni (London/GB),
A Padovani, B Borroni (Brescia/IT)
P184
Epigenetic modification in Italian FTLD patients carrying the C9orf72 repeat
expansion
Irene Piaceri, Andrea Tedde, Gemma Lombardi, Camilla Ferrari, Valentina Bessi,
Sandro Sorbi, Benedetta Nacmias, Silvia Bagnoli (Florence/IT)
P185
NIH EXAMINER as tool for tracking executive dysfunction in carriers of FTLDcausing mutations within the LEFFTDS Consortium
Howard Rosen, Peter Ljubenkov (San Francisco/US), Brad Boeve (Rochester/US),
Joel Kramer, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US),
Christina Dheel, Julie Fields, Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St.
Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US),
Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao
(Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA), Edward D. Huey (New
York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna
Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak (San
Francisco/US), Walter Kukull (Seattle/US), Ian Mackensie (Vancouver/US), Bruce
Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers
(Jacksonville/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US),
Arthur Toga (Los Angeles/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek
(Jacksonville/US), Tatiana Faroud, Kelly Faber, Ashley Vetor (Indianapolis/US), John
Trojanowski (Philadelphia/US), Katherine Rankin (San Francisco/US)
P186
TMEM106B polymorphism is associated with lower cortical volumes in a clinically
diagnosed FTD cohort
Sophie R. Harding, Martina Bocchetta, Elizabeth Gordon, Dave M. Cash, M. Jorge
Cardoso, Gary Adamson, Sebastien Ourselin, Jason D. Warren, Simon Mead,
Jonathan D. Rohrer (London/GB)
P187
The genetic correlation between Frontotemporal Dementia (FTD), and
neurodevelopmental diseases, and the convergence in functional pathways.
Erdogan Taskesen, Aniket Mishra, Danielle Posthuma (Amsterdam/NL), Yolande
Pijnenburg (Amsterdam, Londen/NL)
P188
Familial frontotemporal dementia - ALS syndrome by TARDBP gene mutation
Mikel Olabarrieta, Francesc Pujadas, Antonio Palasi (Barcelona/ES), Antoni Turon
(Salt (Girona)/ES), Anna Antonell (Barcelona/ES), Ellen Gelpi (Barcelona/BE),
Raquel Sánchez-Valle (Barcelona/ES)
23
ICFTD 2016
P189
Absence of Differences on Key Measures in Mildly (CDR=0.5) Versus Overtly
(CDR≥1) Symptomatic Mutation Carriers: Preliminary Data From LEFFTDS
David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San
Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields
(Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),
(Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San
Francisco/US), John Hsiao (Bethesda/US), Edward Huey (New York/US), Robin
Hsiung (Vancouver/CA), David Irwin (Philadelphia/US), Kejal Kantarci
(Rochester/US), Anna Karydas, John Kornak, Joel Kramer (San Francisco/US),
Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San
Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers
Angeles/US), John Trojanowski (Philadelphia/US), Sandra Weintraub (Chicago/US),
Zbigniew Wszolek (Jacksonville/US), Ashley Vetor (Indianapolis/US)
P190
The genetic and epidemiology of frontotemporal dementia in Sardinia
Francesca Di Stefano, Giuseppe Borghero, Antonino Cannas, Angela Sanna
(Monserrato/IT), Maria Rita Murru, Daniela Corongiu, Stefania Cuccu, Stefania
Tranquilli, Maria Giovanna Marrosu (Cagliari/IT), Adriano Chiò (Turin/IT), Francesco
Marrosu, Gianluca Floris (Monserrato/IT)
P191
Differences on Clinical Measures in Asymptomatic (CDR=0) Versus Mildly
Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS
David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San
Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields
(Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),
(Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San
Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward
Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US),
Anna Karydas, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian
Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps
(Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San
Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US),
Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor
(Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek
(Jacksonville/US)
P192
Estimation of Age of Onset in Presymptomatic Frontotemporal Degeneration
Prerana Vaddi, Elisabeth Mccarty Wood, Vivianna Van Deerlin, David Irwin, Murray
Grossman, Corey McMillan (Philadelphia/US)
P193
Targeted Multi-Gene Panel Sequencing in Korean Patients with Frontotemporal
Dementia: A preliminary result
Eun-Joo Kim (Busan/KR), Young-Eun Kim, Ja-Hyun Jang, Eun-Hae Cho
(Yongin/KR), Jay C. Kwon (Changwon/KR), Ki-Hyeong Park (Incheon/KR), Kyung
Won Park (Busan/KR), Jae-Hong Lee (Seoul/KR), Seong Hye Choi (Incheon/KR),
Soo Jin Yoon (Daejeon/KR), Jee H. Jeong, Byung-Ok Choi, Duk L. Na, Chang-Seok
Ki, Seung Hyun Kim (Seoul/KR)
24
ICFTD 2016
P194
Effect of predictive testing in adult onset neurodegenerative diseases on social and
personal life – a pilot study
Petra Cohn-Hokke (Amsterdam/NL), John van Swieten (Amsterdam, Rotterdam/NL),
Aad Tibben (Leiden/NL), Hanne Meijers-Heijboer (Amsterdam/NL), Anneke Kievit
(Rotterdam/NL)
P195
Gene-group based genetic burden tests reveals additional candidate genes for FTD.
Jeroen van Rooij, Tsz-Hang Wong (Rotterdam/NL), Javier Simón-Sánchez, Cornelis
Blauwendraat, Patrizia Rizzu (Tuebingen/DE), Peter Heutink (Tuebingen,
Amsterdam/DE), Matthis Synofzik (Tuebingen/DE), André Uitterlinden, Joyce van
Meurs, John van Swieten (Rotterdam/NL)
P196
The phenotypic variability of c9orf72 mutations: at the interface between neurology
and psychiatry
Carola Rossmeier, Dieter Edbauer, Janine Diehl-Schmid (Munich/DE)
P197
Anthropometric measures of asymptomatic individuals at-risk for familial
Ging-Yuek Hsiung, Pheth Sengdy (Vancouver/CA), Matt Baker, Rosa Rademakers
(Jacksonville/US), Howard Feldman, Ian Mackenzie (Vancouver/CA)
P198
TMEM106B and APOE as genetic modifiers of FTD-3 in the Danish CHMP2B family
Peter Roos, Nina Rostgaard, Peter Johannsen (DK-2100 København Ø/DK), Jeremy
M. Brown (Cambridge, UK/GB), Adrian M. Isaacs (London, UK/GB), Gunhild
Waldemar, Troels T. Nielsen (DK-2100 København Ø/DK), Jørgen E. Nielsen (DK2100 København Ø, Copenhagen, DK/DK)
P199
Probing FTD genetics with a next-generation sequencing gene panel
Carolin Koriath, Gary Adamson, Ron Druyeh, Janna Kenny, Martin Rossor, Jon
Schott, Catherine Mummery, Nick Fox, Jason Warren, John Collinge, Jon Rohrer,
Simon Mead (London/GB)
P200
Reduced disease penetrance of progranulin mutation p.tyr294* - a case report
Linn Öijerstedt (Stockholm, Huddinge, Stockholm/SE), Christin Andersson
(Huddinge, Stockholm/SE), Vesna Jelic, Caroline Graff (Stockholm, Huddinge,
Stockholm/SE)
P201
Prevalence, phenotypic variability and neuropsychological findings of C9orf72
mutations in a Bulgarian dementia cohort
Shima Mehrabian (Sofia/BG), Hakan Thonberg, Bengt Winblad (Stockholm/SE),
Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Katya Stoyanova
(Sofia/BG), Charlotte Forsell (Stockholm/SE), Draga Toncheva (Sofia/BG), Lena
Cavallin, Eric Westman (Stockholm/SE), Latchezar Traykov (Sofia/BG), Caroline
Graff (Stockholm/SE)
P202
Frequency and contribution of variants in 17 dementia related genes in a Bulgarian
dementia cohort
Hakan Thonberg (Stockholm/SE), Shima Mehrabian (Sofia/BG), Bengt Winblad
(Stockholm/SE), Katya Stoyanova (Sofia/BG), Charlotte Forsell (Stockholm/SE),
Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Draga Toncheva,
Latchezar Traykov (Sofia/BG), Caroline Graff (Stockholm/SE)
P203
Double mutations in TREM2 and C9orf72 genes in a Bulgarian individual with
atypical FTD phenotype and rapid progression
Latchezar Traykov, Shima Mehrabian (Sofia/BG), Hakan Thonberg (Stockholm/SE),
Margarita Raycheva (Sofia/SE), Charlotte Forsell (Stockholm/SE), Katya Stoyanova
25
ICFTD 2016
(Sofia/BG), Lena Lilius (Stockholm/SE), Draga Toncheva (Sofia/BG), Mariann
Harangi (Debrecen/HU), Gabor G. Kovacs (Vienna/AT), Bengt Winblad, Caroline
Graff (Stockholm/SE)
P204
Colombian Familial Dementia with Frontotemporal Features Associated with a
Presenilin-1 Mutation
Diana Matallana (Bogotá/CO), Katya Rascovsky (Philadelphia, PA/US), Paola Ayala,
Andrea Lopez, Ignacio Zarante (Bogotá/CO), Corey McMillan, David Irwin, Beth
McCarty-Wood, Viviana Van Deerlin, EunRan Suh, Murray Grossman (Philadelphia,
PA/US)
P205
Sporadic frontotemporal dementia: polygenicity and pleiotropy
Raffaele Ferrari (London/GB), Yunpeng Wang (Oslo/NO), Jana Vandrovcova
(London/GB), Anders M Dale (St. Louis/US), Ole A Andreassen (Oslo/NO), Bruce
Miller, Rahul S Desikan (San Francisco/US)
P206
NeuroX to screen neuro-genes in large FTLD cohort
Raffaele Ferrari, John Hardy (London/GB)
P207
GRN c.708+1_+4delTGAG DELETION IN A LARGE FAMILY DIAGNOSED WITH
FRONTO-TEMPORAL DEMENTIA
Gulsen BABACAN-YILDIZ (Istanbul/TR), Gamze GUVEN, Hasmet HANAGASI,
Basar BILGIC, Hakan GURVIT, Nihan ERGINEL-UNALTUNA (ISTANBUL/TR), Rita
GUEIRREIRO (ISTANBUL/GB), Ebba LOHMANN (ISTANBUL, Tuebingen/DE)
P208
Evaluation of a Novel PCR Technology for the Quantification of C9orf72
Hexanucleotide Repeat Expansions
Eran Bram, Kristen Culp, Nathan Nevitt, Jon Kemppainen, Gary Latham (Austin/US),
EunRan Suh, Kaitlyn Grando, Vivianna Van Deerlin (Philadelphia/US)
P209
CLINICAL AND GENETIC ANALYSES OF FAMILIAL AND SPORADIC
FRONTOTEMPORAL DEMENTIA PATIENTS IN SOUTHERN ITALY ( The
Apulia_FTD_Registry)
Rosa Capozzo (Tricase, Lecce/IT), Celeste Sassi (Bethesda, MD, USA, London,
UK/US), Monia Benahmed-Hammer (Bethesda, MD, USA/US), Simona Arcuti, Chiara
Zecca, Maria Rosaria Barulli, Rosanna Tortelli (Tricase, Lecce/IT), Francesco
Carnicella, Claudia Dell'Aquila (Andria, Italy/IT), Francesco Valluzzi (Monopoli, Italy,
/IT), Francescop Panza (Tricase, Lecce, Bari, Italy/IT), Andrew Singleton (Bethesda,
MD, USA/US), Giancarlo Logroscino (Tricase, Lecce, Bari/IT)
P210
Frontotemporal lobar degeneration spectrum: first genetic screen in a Greek cohort
Eliana Marisa Ramos (Los Angeles, CA, USA/US), Suzee Lee (San Francisco/US),
Christos Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing
Wang, Deepika Dokuru, Mochtar Pribadi (Los Angeles, CA, USA/US), Anastasios
Bonakis, Vasiliki Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce
Miller (San Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los
Angeles, CA, USA/US), Sokratis G. Papageorgiou (Athens/US)
P211
Psychiatric symptoms in CDR=0 MAPT mutation carriers
Edward Huey, Gayathri Cheran, Jill Goldman, Masood Manoochehri, Sarah Cines
(New York, NY/US), Tim Lynch, Brendan Kelly (Dublin/IE), Sarah Shair, Judith
Heidebrink, Henry Paulson (Ann Arbor/US), Stephanie Cosentino (New York, NY/US)
P212
Investigation of Mutation Related Covariance Pattern in Asymptomatic Carriers of
GRN and C9ORF72 mutations using [F18]-FDG PET
26
ICFTD 2016
Elham Shahinfard, Jessie Fu (Vancouver, B.C./CA), Claudia Jacova (Oregon/US),
Dinelle Katie, Pheth Sengdy, Siobhan McCormick (Vancouver, B.C./CA), Vesna
Sossi (Vancouver, Vancouver, B.C./CA), A. Jonathan Stoessl, Howard Feldman, Ian
Mackenzie, Ging-Yuek Robin Hsiung (Vancouver, B.C./CA)
P213
Results of a diagnostic NGS gene panel for patients with dementia.
Resie Vervenne - van Spaendonk, Fred van Ruissen, Margriet Smit, Daphne van
Beek, Petra Cohn-Hokke, Erik Sistermans, Janneke Weiss (Amsterdam/NL)
P214
Genetic mutations in Frontemporal dementia - report from the memory clinic from
Serbia
Elka Stefanova, Gorana Mandic, Valerija Dobricic, Tanja Stojkovic, Milena Jankovic,
Ivana Novakovic, Vladimir Kostic
P215
Closing the tau loop: the missing tau mutation
Allan McCarthy (Dublin/IE), Roisin Lonergan (Dublin/US), Diana Olszewska, Sean
O'Dowd (Dublin/IE), Gemma Cummins (Cambridge/GB), Brian Magennis, Emer
Fallon, Niall Pender (Dublin/IE), Edward Huey, Stephanie Cosentino (New York,
NY/US), Killian O'Rourke, Brendan Kelly, Martin O'Connell (Dublin/IE), Isabelle Delon
(Cambridge/GB), Michael Farrell (Dublin/IE), Maria Grazia Spillantini
(Cambridge/GB), Lewis Roland, Stanley Fahn (New York, NY/US), Peter Craig,
Michael Hutton (Surrey/GB), Tim Lynch (Dublin/IE)
P216
Bioinformatics and FTD: using genes to untangle molecular underpinnings of disease
Raffaele Ferrari (London/GB)
P217
C9orf72 repeat expansions and TARDBP mutations in two Brazilian Dementia
Research Centers
Leonel Takada, Valeria Bahia (Sao Paulo/BR), Henrique Guimarães, Leonardo
Souza (Belo Horizonte/BR), Thais Costa (Sao Paulo/BR), Thiago Vale (Belo
Horizonte/BR), Roberta Rodriguez, Fabio Porto (Sao Paulo/BR), João Machado,
Rogério Beato (Belo Horizonte/BR), Karolina Cesar, Jerusa Smid, Sonia Brucki,
Jessica Maximino (Sao Paulo/BR), Sarah Camargos (Belo Horizonte/BR), Gerson
Chadi (Sao Paulo/BR), Paulo Caramelli (Belo Horizonte/BR), Ricardo Nitrini (Sao
Paulo/BR)
12:00–14:00
Room
Postersession II - Neuropathology
Ballroom
P218
Multiple accumulation of neurodegenerative disease-related proteins in familial
granulin mutation brains
Masato Hosokawa (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Hiromi Kondo
(Tokyo/JP), Geidy Serrano, Thomas Beach (Sun City/US), Masato Hasegawa,
Haruhiko Akiyama (Tokyo/JP)
P219
P301L MAPT mutation with globular glial inclusions
Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau
(Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Albert
Lladó, Raquel Sánchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)
27
ICFTD 2016
P220
Clinical and neuropathological features of Frontotemporal dementia caused by the
P301L MAPT mutation in Baix Llobregat County (Barcelona, Spain)
Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau
(Barcelona/ES), Ramón Reñé (Hospitalet del Llobregat/ES), Isabel Hernández
(Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Anna
Antonell, Albert Lladó (Barcelona/ES), Ellen Gelpi (Barcelona/BE), Raquel SánchezValle (Barcelona/ES)
P221
Generation of specific and sensitive antibodies against C9orf72
Petra Frick (Tuebingen/DE), Dieter Edbauer, Elisabeth Kremmer, Regina Feederle
(Munich/DE), Ian Mackenzie (Vancouver/CA), Jeroen Pasterkamp (Utrecht/NL),
Manuela Neumann (Tuebingen/DE)
P222
CLINICAL AND NEUROPATHOLOGICAL CLASSIFICATION OF
FRONTOTEMPORAL DEMENTIA: ANALYSYS OF COMMON AND SPECIFIC
CHARACTERISTICS
María José Gil Moreno (Madrid/ES), María Sagrario Manzano Palomo (Parla,
Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez (Madrid/ES)
P223
CEREBROVASCULAR PATHOLOGY IN FRONTOTEMPORAL LOBAR
DEGENERATION: A NEUROPATHOLOGICAL STUDY
Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Guitérrez
(Madrid/ES)
P224
ARGYROPHILIC GRAINS PATHOLOGY IN FRONTOTEMPORAL LOBAR
DEGENERATION
Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez
(Madrid/ES)
P225
Neuropathology of ALS with Dementia
Eileen Bigio, Yasushi Nishihira, Qinwen Mao, Sandra Weintraub, Nailah Siddique,
Teepu Siddique, M-Marsel Mesulam (Chicago/US)
P226
106 FTD cases with refined neuropathological confirmation.
Anne Sieben (Wilrijk, Gent, Antwerp/BE), Sara Van Mossevelde, Julie van der Zee
(Wilrijk, Antwerp/BE), Joery Goossens (Wilrijk/BE), Peter Paul De Deyn (Wilrijk,
Groningen, Antwerp/BE), Patrick Cras (Wilrijk, Edegem/BE), Sebastiaan
Engelborghs, Christine Van Broeckhoven (Wilrijk, Antwerp/BE), Jean-Jacques Martin
(Wilrijk/BE)
P228
The effect of fetal and perinatal asphyxia on familial frontotemporal dementia gene
transcription as studied in a rat model.
Melinda Barkhuizen (Maastricht, The Netherlands, Potchefstroom, South Africa/NL),
Phyllis van der Ploeg, Fleur van Dijck, Kimberly Cox-Limpens (Maastricht, The
Netherlands/NL), Daniel van den Hove (Maastricht, The Netherlands, Würzburg,
Germany/NL), Harry Steinbusch, Boris Kramer (Maastricht, The Netherlands/NL),
Danilo Gavilanes (Maastricht, The Netherlands, Guayaquil, Equador/NL)
P229
MAPT mutations and sporadic frontotemporal tauopathies: lost in translation?
Shelley Forrest, Jillian Kril (Camperdown/AU), John Kwok (Randwick/AU), Maria
Grazia Spillantini (Cambridge/GB), John Hodges, Glenda Halliday (Randwick/AU)
P230
Targeting the cytoskeleton in frontotemporal dementia
Anna King, Nan Tian, Rachel Atkinson, James Vickers (Hobart/AU)
28
ICFTD 2016
P231
Clinical and pathological study of FTLD-FUS presenting chorea
Ito Kawakami (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Zen Kobayashi
(Tokyo/JP), Osamu Yokota (Okayama/JP), Takashi Nonaka, Kazuhiro Niizato,
Kenichi Oshima (Tokyo/JP), Shinji Higashi (Tokyo, Tsukuba/JP), Masato Hosokawa,
Masato Hasegawa, Haruhiko Akiyama (Tokyo/JP)
P232
Clinicopathological correlation of frontotemporal dementia disorders
Christer Nilsson, Christina Elfgren, Karin Nilsson, Ulla Passant, Alexander Frizell
Santillo, Susanna Vestberg, Maria Landqvist Waldö, Danielle van Westen, Elisabet
Englund (Lund/SE)
P233
pThr175 tau is associated with tau pathology in a spectrum of tauopathies
Alexander Moszczynski, Wencheng Yang, Michael Strong (London/CA)
P234
An AAV9 mediated rat model of pThr175 tau protein toxicity
Alexander Moszczynski, Jason Gopaul, Patrick Mccunn, Kathryn Volkening,
Madeline Harvey, Robert Bartha, Susanne Schmid, Michael Strong (London/CA)
P235
pThr175 tau as a toxic phosphoepitope in CTE and ALSci
Alexander Moszczynski (London/CA), Ann McKee (Boston/US), Wendy Strong,
Michael Strong (London/CA)
P236
Selective vulnerability of the locus coeruleus in frontotemporal lobar degeneration
(FTLD) with tau pathology
David Irwin, Mathew Byrne, David Wolk, Edward Lee, Murray Grossman, John
Trojanowski (Philadelphia/US)
P237
Prevalence of Amyloid pathology and PiB positivity in Frontotemporal dementia
Rachel Tan (Randwick, Sydney/AU), Jillian Kril (Sydney/AU), Yue Yang
(Randwick/AU), Olivier Piguet (Randwick, Sydney/AU), Lars Ittner (Sydney/AU), John
Kwok, John Hodges, Glenda Halliday (Randwick, Sydney/AU)
P238
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in
Niemann- Pick Disease Type C
Stefania Zampieri (Udine/IT), Sonia Canterini (Rome/IT), Kathy Newell (Kansas City,
Kansas/US), Cristiana Stuani (Trieste/IT), Jill Murrell, Bernardino Ghetti (Indianapolis,
Indiana/US), Maria Teresa Fiorenza (Rome/IT), Bruno Bembi (Udine/IT), Emanule
Buratti (Trieste/IT), Andrea Dardis (Udine/IT)
P239
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal
lysosomal storage pathology
Emma Clayton, Sarah Mizielinska (London/GB), James Edgar (Cambridge/GB),
Troels Tolstrup Nielsen (Copenhagen/DK), Ida Holm (Randers, Aarhus/DK), Peter
Johannsen, Jørgen Nielsen (Copenhagen/DK), Emmanuel Asante, John Collinge
(London/GB), FReJA Consortium (Jutland/GB), Adrian Isaacs (London/GB)
P240
Pathological prediction in behavioral variant frontotemporal dementia
David Perry, Jesse Brown, Katherine Possin, Andrew Trujillo, Anneliese Radke, Anna
Karydas, Ana Sias, Gil Rabinovici, Maria Luisa Gorno-Tempini, Adam Boxer, Mary
De May, Eric Huang, Katherine Rankin, Suzee Lee, Manu Sidhu, Stephanie Gaus,
Jose Vargas, Rik Ossenkoppele, Alainna Brown (San Francisco, CA/US), Giovanni
Coppola (Los Angeles, CA/US), Howard Rosen (San Francisco, CA/US), Daniel
Geschwind (Los Angeles, CA/US), John Trojanowski (Philadelphia, PA/US), Lea
Grinberg, Joel Kramer, Bruce Miller, William Seeley (San Francisco, CA/US)
29
ICFTD 2016
P241
TDP-43 Pre-Inclusions in Primary Progressive Aphasia: Morphology and Distribution
Garam Kim, Zach Parton, Sandra Weintraub, Eileen Bigio, M.-Marsel Mesulam,
Changiz Geula (Chicago/US)
P242
Sporadic FTLD TDP type C is a distinct clinicopathological entity from FTLD types
A/B
G Michael Baer, Matthew Byrne, Felicia Cooper, EunRan Suh, Leo McCluskey,
Lauren Elman, David Wolk, Vivianna M. Van Deerlin, Virginia Lee, Edward Lee,
Murray Grossman, John Trojanowski, David J. Irwin (Philadelphia/US)
P243
Tau aggregation and neurodegeneration predict regional atrophy and intrinsic
connectivity disruption in progressive supranuclear palsy
Salvatore Spina, Jesse A. Brown, Jersey Deng, Alissa Nana Li, Norbert Lee, Ji-Hye
Hwang, Stephanie E. Gaus, Eric J. Huang, Adam Boxer, Howard J. Rosen, Bruce L.
Miller, Lea Grinberg, William W. Seeley (San Francisco/US)
P244
TDP-43 Protein Pathology in Mouse Model's of Alzheimer's Disease
Liam Kaylor (Aurora, Hobart/US)
P245
Disproportionate von Economo neuron and fork cell TDP-43 aggregation is
associated with somatodendritic degeneration in sporadic behavioral variant FTD
Alissa Nana, Manu Sidhu, Stephanie Gaus, Ji-Hye Hwang (San Francisco/US), Libo
Li (San Francisco, Qiqihar/CN), Youngsoon Park, Eun-Joo Kim, Stephen DeArmond,
Lea Grinberg, Eric Huang, Bruce Miller, William Seeley (San Francisco/US)
P246
Utility of Ubiquitin/p62 aggregates screening in granular neurons of the cerebellar
cortex in a Brain Bank: experience of the Neurological Tissue Bank of the BiobancHospital Clinic-IDIBAPS,Barcelona(Spain)
Rainiero Avila (Sevilla, Barcelona/ES), Oscar Ramos, Oriol Grau, Anna Antonell,
Albert Lladó, Raquel Sanchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)
P247
Hypertrophic microglia are associated with more tangles and less neurons in primary
progressive aphasia with Alzheimer pathology
Daniel Ohm, Alfred Rademaker, Eileen Bigio, M.-Marsel Mesulam, Emily Rogalski,
Changiz Geula (Chicago/US)
P248
Biopsy in Dementia: A case report
Catharina Prix, Johannes Levin (Munich/DE), Nibal Ackl (Munich, Münsterlingen/CH),
Elisabeth Wlasich, Rupert Egensperger, Christoph Schwartz, Friedrich-Wilhelm
Kreth, Armin Giese, Adrian Danek (Munich/DE)
P249
C9ORF72 in 3D: A Novel Dimension in FTD-MND iPSN Cultures
Veronica Porterfield, Qing Zhong, Phylindia Gant, Erin Foff (Charlottesville/US)
P250
ER chaperones in the pathogenesis of amyotrophic lateral sclerosis (ALS)
ANAND GOSWAMI, Alfred Yamoah, Alice Dreser (Aachen/DE), Dirk Troost
(Amesterdam/NL), Joachim Weis (Aachen/DE)
P251
Cerebellar c9RAN proteins associate with clinical and neuropathological
characteristics of C9ORF72 repeat expansion carriers
Tania Gendron, Marka van Blitterswijk, Kevin Bieniek, Lillian Daughrity
(Jacksonville/US), Jie Jiang (La Jolla/US), Beth Rush, Otto Pedraza, John Lucas,
Melissa Murray, Pamela Desaro, Amelia Robertson, Karen Overstreet, Colleen
Thomas, Julia Crook, Monica Castanedes-Casey, Linda Rousseau (Jacksonville/US),
Keith Josephs, Joseph Parisi, David Knopman, Ronald Petersen, Bradley Boeve
(Rochester/US), Neill Graff-Radford, Rosa Rademakers (Jacksonville/US), Clotilde
30
ICFTD 2016
Lagier-Tourenne (Charlestown/US), Dieter Edbauer (Munich/DE), Don Cleveland (La
Jolla/US), Dennis Dickson, Leonard Petrucelli, Kevin Boylan (Jacksonville/US)
P252
Pick ‘n’ mix: neuropathological detection of peri-tumour tauopathy.
Roisin Lonergan (Dublin/US), Vijay Ashankar, Fiona Carty, Michael Alexander, Peter
Kelly, Killian O'Rourke, Michael Farrell, Tim Lynch (Dublin/IE)
12:00–14:00
Room
Postersession II - Progressive aphasias
Ballroom
P253
Eyes Reveal Semantic Deficit Early in Primary Progressive Aphasia
Argye Hillis, David Race (Baltimore/US)
P254
Semantic dementia and the left and right temporal lobes
Julie Snowden, Jennifer Harris, Jennifer Thompson, Christopher Kobylecki, Matthew
Jones, Anna Richardson, David Neary (Manchester/GB)
P255
UK speech and language therapy services for Primary Progressive Aphasia (PPA):
Referral patterns and barriers to access.
Anna Volkmer, Jason Warren, Aimee Spector, Suzanne Beeke (London/GB)
P256
Dynamic perceptual ‘stress tests’ in primary progressive aphasia
Chris Hardy, Rebecca Bond, Kankamol Jaisin, Charles Marshall, Camilla Clark, Lucy
Russell, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)
P257
Distinctive clinical presentations in Asian patients with left and right anterior temporal
atrophy
Amitabha Ghosh (Kolkata/IN), Ryuji Fukuhara (Kumamoto/JP), Adeline Ng Su Lyn
(Singapore/SG), Jacqueline Dominguez (Manila/PH), Paulus Anam Ong
(Bandung/ID), Aparna Dutt, Kishalaya Karan (Kolkata/IN), Manabu Ikeda
(Kumamoto/JP)
P258
Functional neuroanatomy of speech signal decoding in primary progressive aphasias
Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood,
David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren
(London/GB)
P259
Progressive aphasias as disorders of auditory information processing: behavioural
signatures and structural neuroanatomy
Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood,
David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren
(London/GB)
P260
Cross-sectional and longitudinal features of non-fluent/agrammatic primary
progressive aphasia with underlying corticobasal degeneration or progressive
supranuclear palsy pathology.
Miguel Angel Santos-Santos, Maria Luisa Mandelli (San Francisco/US), Richard J.
Binney (Philadelphia, San Francisco/US), Edoardo Spinelli (Milan, San Francisco/IT),
Jennifer Ogar (San Francisco/US), Maya L. Henry (Austin, San Francisco/US), Isabel
Hubbard (San Francisco/US), Stephen M. Wilson (Tuscon, San Francisco/US), John
Q. Trojanowski (Philadelphia/US), Lea T. Grinberg, Howie Rosen, Adam L. Boxer,
Bruce L. Miller, William W. Seeley, Maria Luisa Gorno-Tempini (San Francisco/US)
31
ICFTD 2016
P261
Grammatical dissociation in a Primary Progressive Aphasia patient: a prospective
assessment
Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello, Juan Pablo Barreyro, Teresa
Torralva, Facundo Manes, Macarena Martinez-Cuitiño (Buenos Aires/AR)
P262
Concreteness effect in a Semantic variant of Primary Progressive Aphasia patient:
semantic processing and neuroanatomic areas
Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello (Buenos Aires/AR), Teresa
Torralva (BUenos Aires/AR), Facundo Manes, Macarena Martinez-Cuitiño (Buenos
Aires/AR)
P263
Distinct neural correlates underlying the relative preservation of episodic memory in
semantic-variant PPA
Muireann Irish, Steffie Bunk, Sicong Tu (Sydney/AU), Michael Hornberger (Sydney,
Norwich/GB), John Hodges, Olivier Piguet (Sydney/AU)
P264
Focal Temporal Pole Atrophy and Network Degeneration in Semantic Variant Primary
Progressive Aphasia
Jessica Collins (Charlestown/US), Victor Montal (Barcelona/ES), Maria Luisa GornoTempini (San Francisco/US), Brad Dickerson (Charlestown/US)
P265
Limited abstract word processing in behavioral variant frontotemporal degeneration
Katheryn Cousins, Sharon Ash, Murray Grossman (Philadelphia/US)
P266
Patterns of hippocampal atrophy and memory loss among language subtypes of
Frontotemporal dementia and Alzheimer’s disease
Jagan Pillai, Aaron Bonner-Jackson, Michael Parsons, James Leverenz
(Cleveland/US)
P267
Transcranial direct current stimulation as a potential therapy for symptoms of Primary
Progressive Aphasia
Nicole White, Felix Gervits, Sharon Ash, H. Branch Coslett, Roy Hamilton, Murray
Grossman (Philadelphia/US)
P268
Neural Network Underlying Abnormal Syntax Processing in Primary Progressive
Aphasia: Evidence from Resting State Functional Magnetic Resonance Imaging
Borna Bonakdarpour, Allan Wang, Emily Rogalski, Robert Hurley, Marsel Mesulam
(Chicago/US)
P269
Recognizing Primary Progressive Aphasia between Frontotemporal Dementia
variants: Denomination mistakes like a tool for differential diagnosis
Nathalia Rodriguez, María Del Pilar Mayorga Sierra, Diana Lucía Matallana Eslava
(Bogotá/CO)
P270
Principal components analysis of neuropsychological features in nonfluent and
logopenic variant PPA
Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary,
Julie Snowden, Jennifer Thompson (Manchester/GB)
P271
Characterising Primary progressive Aphasia – a neuropsychological study
Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary,
Julie Snowden, Jennifer Thompson (Manchester/GB)
P272
MRI in nonfluent and logopenic variant PPA: ASl, DTI and VBM
Jennifer Harris, Jennifer Adams, Jennifer Thompson, Laura Parkes, Stephen Carter,
Anna Richardson, David Neary, Julie Snowden, Matthew Jones (Manchester/GB)
32
ICFTD 2016
P273
Different biomarkers of neurodegeneration in the CSF distinguishing progressive
non-fluent aphasia from other frontotemporal dementias
Peter Koertvelyessy (Magdeburg/DE), Johannes Prudlo (Rostock/DE), Hans-Jochen
Heinze, Daniel Bittner (Magdeburg/DE)
P274
Quantification of motor speech in primary progressive aphasia and frontotemporal
dementia
Matthew Poole (Parkville, Melbourne/AU), Amy Brodtmann, David Darby
(Melbourne/AU), Adam Vogel (Parkville, Melbourne, Tubingen/AU)
P275
Apraxia profiles - A novel cognitive marker for differentiating clinical variants of FTLD
and AD
Andreas Johnen, Sophia Reul, Thomas Duning, Hubertus Lohmann (Münster/DE)
P276
PPA interventions with impact: Making everyone happy
Regina Jokel (Toronto/CA)
P277
Artificial Grammar Learning in Vascular and Progressive Non-Fluent Aphasia
Identifies Domain General Impairments.
Thomas E Cope (Cambridge/GB), Benjamin Wilson (Newcastle/GB), Holly Robson
(Reading/GB), Lauren Dean, Manon Grube (Newcastle/GB), Karalyn Patterson
(Cambridge/GB), Timothy D Griffiths (Newcastle/GB), James B Rowe
(Cambridge/GB), Chris Petkov (Newcastle/GB)
P278
PET-FLORBETAPIR FINDINGS IN PRIMARY PROGRESSIVE APHASIA.
Alberto Villarejo, Sara Llamas-Velasco, Adolfo Gomez-Grande, Verónica PuertasMartín, Pilar Sarandeses-Fernández, Marta Gonzalez-Sánchez, Sebastian RuizSolis, Patrick Pilkington, David A. Pérez-Martínez, Alejandro Herrero-San Martín
(Madrid/ES)
P279
Developing an international graded naming task.
Ornella Billette (Magdeburg/DE), Zsolt Cséfalvay (Magdeburg/SK), Elisabeth Tute,
Peter Nestor (Magdeburg/DE)
P280
Classifying primary progressive aphasias individually with support vector machine
approaches in MRI data
Sandrine Bisenius, Karsten Mueller (Leipzig/DE), Janine Diehl-Schmid (Munich/DE),
Klaus Fassbender (Homburg/DE), Frank Jessen (Bonn/DE), Jan Kassubek (Ulm/DE),
Johannes Kornhuber (Erlangen/DE), Anja Schneider (Goettingen/DE), Katharina
Stuke (Leipzig/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE), Matthias L.
Schroeter (Leipzig/DE), FTLD Study Group Germany (Ulm/DE)
P281
Electrostimulation effects in the logopenic and non-fluent variants of primary
progressive aphasia
Kyrana Tsapkini, Tushar Chakravarty, Bronte Ficek, Kim Webster, John Desmond,
Chiadi Onyike, Constantine Frangakis, Argye Hillis (Baltimore/US)
P282
Verb regularization errors as an analogue for surface dyslexia in semantic dementia
in languages with high grapheme-phoneme transparency
Ornella Billette, Daniel Preiß, Peter Nestor (Magdeburg/DE)
P283
Aspects of natural conversation in primary progressive aphasia.
Cathleen Taylor-Rubin (Waverley, Sydney, Sydney/AU), Karen Croot, Emma Power
(Sydney/AU), Sharon A. Savage (Exeter/GB), John R. Hodges, Leanne Togher
(Sydney/AU)
33
ICFTD 2016
P284
Semantic dementia with combined TDP-43 and FUS pathology
Maria Landqvist Waldö, Christina Elfgren, Lars Gustafson, Ulla Passant (Lund/SE),
Alexander Frizell Santillo (Malmö/SE), Elisabet Englund (Lund/SE)
P285
Common and divergent neural correlates of anomia in amnestic and logopenic
presentations of Alzheimer’s disease
Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)
P286
Dissecting neurocognitive mechanisms underpinning sentence-processing deficits in
PPA
Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)
P287
Convergent language network involvement in non-semantic PPA variants
Cristian Leyton, Ramon Landin-Romero, Fiona Kumfor, James Burrell, John Hodges,
Olivier Piguet (Sydney/AU)
P288
Domain Specific learning Disabilities within Atypical neurodenerative diseases
primary progressive aphasia and Posterior Cortical atrophy
Zachary Miller (San Francisco/US), Lynne Rosenberg (New York/US), Miguel
Santos, Melanie Stephens, Maria Luisa Mandelli, Gil Rabinovici, Bruce Miller, Maria
Luisa Gorno-Tempini (San Francisco/US)
P289
Lexical representation and parsing of morphologically complex words in non-fluent
variant PPA and non-fluent post-stroke aphasia
Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Gonia
Jarema (Montréal/CA), Kyrana Tsapkini (Baltimore/US)
P290
Executive functions in non-fluent variant PPA: A comparison to non-fluent post-stroke
aphasia
Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana
Tsapkini (Baltimore/US)
P291
The effect of verbal working memory capacity in sentence comprehension: A
comparison between non-fluent post-stroke aphasia and non-fluent variant PPA
Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana
Tsapkini (Baltimore/US)
P292
Non-right handed primary progressive aphasia and apraxia of speech
Hugo Botha, Jennifer Whitwell, Joseph Duffy, Edythe Strand, Mary Machulda, Val
Lowe, Keith Josephs (Rochester/US)
P293
Neurochemical markers in the differential diagnosis of primary progressive aphasias:
Data from the German FTLD consortium
Patrick Oeckl, Sarah Anderl-Straub (Ulm/DE), Janine Diehl-Schmid (Munich/DE),
Christine A.F. von Arnim (Ulm/DE), Klaus Fassbender (Homburg/DE), Emily
Feneberg (Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Holger
Jahn (Hamburg/DE), Bernhard Landwehrmeyer (Ulm/DE), Martin Lauer
(Würzburg/DE), Johannes Levin (Munich/DE), Albert C. Ludolph (Ulm/DE), Johannes
Prudlo (Rostock/DE), Anja Schneider (Göttingen/DE), Matthias Schroeter
(Leipzig/DE), Elisa Semler, Petra Steinacker, Ingo Uttner (Ulm/DE), Jens Wiltfang
(Göttingen/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE)
P294
Speech fluency as a tool to differentiate between FTLD variants.
Angela Martínez (Bogotá, Lyon/CO), Diana Matallana (Bogotá/CO), Frédérique
Gayraud (Lyon/FR)
34
ICFTD 2016
P295
Predicting rate of clinical decline using neuroimaging in progressive agrammatic
aphasia and apraxia of speech
Jennifer Whitwell, Stephen Weigand, Joseph Duffy, Heather Clark, Edythe Strand,
Mary Machulda, Anthony Spychalla, Matthew Senjem, Clifford Jack, Keith Josephs
(Rochester/US)
P296
Cross-cultural Adaptation of the Boston Diagnostic Aphasia Examination - Short
Form in Filipino
Howell Henrian Bayona (Taguig City, Manila, Philippines/PH), Ivan Paul Bondoc
(Honolulu, Hawaii/US), Ellyn Loise Namoro, Fatima Faye Aclan, Alrenzo Ludwig
Domingo (Manila, Philippines/PH), Jacqueline Dominguez (Taguig City/PH)
P297
Long-Term functional and behavior features of Primary Progressive Aphasia
Syndrome.
Ismael L Calandri, María Alejandra Amengual, Daiana Actis, Ricardo F Allegri
(Buenos Aires/AR)
P298
Is the impairment on Luria three-step examination in FTD patients associated with
language impairments?
Linda Repetto, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H. Bak
(Edinburgh/GB)
P299
Different patterns of motor impairment in the behavioural and aphasic form of
Frontotemporal Dementia
Giulia Melchiorre, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H Bak
(Edinburgh/GB)
P300
Predictors of conversion to dementia in Primary Progressive Aphasia
Laura Veronelli (Milan, Italy, Boston, MA/IT), Sara J. Makaretz, Megan Quimby
(Boston, MA/US), Massimo Corbo (Milan, Italy/IT), Bradford C. Dickerson (Boston,
MA/US)
P301
Distinctive profile of verbal fluency tasks and overall cognitive functioning in a
Mexican sample in patients with frontotemporal dementia and Alzheimer's disease
José Alberto Téllez Martínez, Juan Francisco Flores Vázquez, Gilberto Isaac Acosta
Castillo, Airam Campos Jiménez, Loreli Álvarez Díaz, Adrian Martínez Ruíz, Ana
Luisa Sosa Ortíz (México/MX)
P302
Assessment of frontal function and behavioral symptoms across subtypes of primary
progressive aphasia, semantic dementia and progressive apraxia of speech
Erin Golden (Rochester/GB), Hugo Botha, Joseph Duffy, Edythe Strand, Heather
Clark, Mary Machulda, Jennifer Whitwell, Keith Josephs (Rochester/US)
P303
Cognitive and neuroanatomical features of amyloid positivity in primary progressive
aphasia (PPA)
Miguel Angel Santos-Santos, Gil D. Rabinovici, Nagehan Ayakta, Leonardo
Iaccarino, Gautam Tammewar, Maya L. Henry, Andreas Lazaris, Zachary Miller,
Maria Luisa Mandelli, Edoardo Spinelli, H. Isabel Hubbard, Howie Rosen, William
Jagust, Bruce L. Miller, Lea T. Grinberg, William W. Seeley, Maria Luisa GornoTempini (san francisco/US)
P304
Differentiating Frontotemporal Dementia Phenotypes in a Cinical Setting Using the
Computerized Self-Test (CST)
Monica Crane, Robert Anthony, Kevin Sellers, Kelly Knolton, John H. Dougherty
(Knoxville/US)
35
ICFTD 2016
14:00–15:30
Room
Chairs
Session 6: CBS, PSP and MND
Lecture Hall
Günter Höglinger (Munich/DE), Albert Ludolph (Ulm/DE)
14:00
PSP & CBD: overlaps and distinctions within the FTLD spectrum
Günter Höglinger (Munich/DE)
14:25
ALS - Pathology, genotype and phenoptype
Albert Ludolph (Ulm/DE)
14:50
Plasma neurofilament light chain predicts disease progression in progressive
supranuclear palsy
Julio Rojas, Anna Karydas, Jee Bang, Richard Tsai (San Francisco, CA/US), Kaj
Blennow, Victor Liman (Gothenburg/SE), Joel Kramer, Howard Rosen, Bruce Miller
(San Francisco, CA/US), Henrik Zetterberg (Gothenburg, London/SE), Adam Boxer
(San Francisco, CA/US)
O11
15:05
O12
15:20
DB19
15:22
DB20
15:24
DB21
Converging Multimodal Evidence of Myelin Associated Proteins As Biomarkers in
Four-Repeat Tauopathy
Corey McMillan, David Irwin, Matthew Byrne, Felicia Cooper, Kim Firn, Charles
Jester, Eunran Suh, Vivianna Van Deerlin, John Trojanowski, Murray Grossman
(Philadelphia/US)
Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and metaanalysis
Zhangyu Zou, Chunhui Che, Changyun Liu, Huapin Huang (Fuzhou/CN)
[18F]AV-1451 PET imaging differentiates the tauopathies of Progressive
Supranuclear Palsy (PSP) and Alzheimer’s disease (AD)
Patricia Vazquez Rodriguez, Luca Passamonti (Cambridge/GB)
On The Clinical Overlap Between Progressive Supranuclear Palsy and Corticobasal
Syndrome: evidence from the PiPPIN epidemiology study
James Rowe, Ian Gilchrist (Cambridge/GB)
15:26
DB22
Clinical comparison of FTLD and ALS-FTD patients – is there a difference?
Angela Rosenbohm, Raphael S Peter, Elisa Semler, Gabriele Nagel, Dietrich
Rothenbacher, Markus Otto, Albert C Ludolph, ALS-FTLD Register Swabia Study
Group (Ulm/DE)
16:00–17:30
Room
Chairs
Session 7: Biomarkers for FTLD
Lecture Hall
Markus Otto (Ulm/DE), Alessandro Padovani (Brescia/IT)
16:00
New physiological biomarkers of FTLD
Jason Warren (London/GB)
16:25
Blood and CSF biomarkers in the presymptomatic stage of hereditary FTD
John van Swieten (Rotterdam/NL)
36
ICFTD 2016
16:50
O13
17:05
O14
17:20
DB23
17:22
DB24
Data-driven Regions of Interest for Longitudinal Change in Three Variants of
Frontotemporal Lobar Degeneration
Howard Rosen, Richard Binney, Aleksandr Pankov, Gabriel Marx, Faye McKenna,
Xuanzie He, Adam Staffaroni, John Kornak, Suneth Attygalle, Adam Boxer, Norbert
Schuff, Maria-Luisa Gorno-Tempini, Michael Weiner, Joel Kramer, Bruce Miller (San
Francisco/US)
Multimodal imaging analysis of C9orf72-associated FTD in the Genetic
Frontotemporal dementia Initiative (GENFI) study
Martina Bocchetta, Nicolas Toussaint, Michael Hutel, Marc Modat, M. Jorge Cardoso,
Elizabeth Gordon, Katrina M Dick, David M Cash (London/GB), John van Swieten
(Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milan/IT), Mario
Masellis (Toronto/CA), Caroline Graff (Huddinge, Stockholm/SE), Fabrizio Tagliavini
(Milan/IT), Giovanni B Frisoni (Brescia/IT), Robert Laforce Jr (Québec City/CA),
Elizabeth Finger (London Ontario/CA), Alexandre de Mendonça (Lisbon/PT), Sandro
Sorbi (Florence/IT), Jason D Warren, Sebastien Ourselin, Jonathan D. Rohrer, on
behalf of the Genetic FTD Initiative (GENFI) (London/GB)
Increased CSF levels of biomarkers for neurodegeneration in FTLD-GRN mutation
carriers.
Joery Goossens, Sara Van Mossevelde, Tobi Van den Bossche, Anne Sieben, JeanJacques Martin, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven,
Julie van der Zee, Sebastiaan Engelborghs (Antwerp/BE)
Presymptomatic structural connectivity loss in familial frontotemporal dementia – a
four year follow-up study of Dutch FTD pedigrees
Lize Jiskoot, Jessica Panman, Elise Dopper, Janne Papma (Rotterdam/NL), Mark
Bouts, Christiane Möller (Leiden/NL), Tom den Heijer, Rick van Minkelen
(Rotterdam/NL), Serge Rombouts (Leiden/NL), John van Swieten (Rotterdam/NL)
17:24
DB25
Exosomal microRNAs in the cerebrospinal fluid as biomarkers in familial FTD
Raphael Schneider, TaeHyung Kim, Paul McKeever (Toronto/CA), Caroline Graff
(Stockholm/SE), John van Swieten (Rotterdam/NL), Robert Laforce Jr (Quebec
City/CA), Daniela Galimberti (Milan/IT), Mario Masellis (Toronto/CA), Jonathan
Rohrer (London/GB), Zhaolei Zhang, Janice Robertson, Maria Carmela Tartaglia
(Toronto/CA)
17:26
DB26
Brain glucose metabolic abnormalities differ between predementia carriers of GRN
and C9ORF72 mutations
Claudia Jacova (Hillsboro/US), Ging-Yuek Robin Hsiung, Elham Shahinfard, Katie
Dinelle, Pheth Sengdy, Siobhan McCormick, Vesna Sossi, A. Jon Stoessl, Howard
Feldman, Ian R Mackenzie (Vancouver/CA)
19:00–00:00
Room
Social Evening
Hofbräukeller
37
ICFTD 2016
08:30–09:30
Room
Chairs
Session 8: Hot topics - Late breaking news
Lecture Hall
Glenda Halliday (Sydney/AU), Masato Hasegawa (Tokyo/JP)
08:30
Selected Talk (To be selected after Late breaking news abstract submission
deadline)
08:45
Selected Talk (To be selected after Late breaking news abstract submission
deadline)
09:00
O15
A mouse model for FTD-like syndrome due to TREM2 mutations
Gernot Kleinberger, Benedikt Wefers, Marc Suárez-Calvet, Fargol Mazaheri
(Munich/DE), Atanas Todorov (Basel/CH), Matthias Brendel (Munich/DE), Eva
Mracsko (Basel/CH), Wolfgang Wurst (Munich/DE), Thomas Mueggler (Basel/CH),
Axel Rominger (Munich/DE), Irene Knuesel (Basel/DE), Christian Haass (Munich/DE)
09:15
DB27
TDP-43 loss of function inhibits endosomal trafficking and alters signaling in neurons
Benjamin Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin Schludi
(Munich/DE), Daniel Hornburg, Felix Meißner (Martinsried/DE), Michael Peitz
(Bonn/DE), Thomas Klopstock (Munich/DE), Albert Ludolph (Ulm/DE), Thomas
Arzberger, Peer-Hendrik Kuhn, Dieter Edbauer (Munich/DE)
09:17
Neuronal Progranulin Overexpression Reverses Social Deficits in Progranulininsufficient Mice
Andrew Arrant, Anthony Filiano, Daniel Unger, Allen Young, Erik Roberson
(Birmingham, AL/US)
DB28
09:19
DB29
Trehalose enhances progranulin expression in progranulin-deficient patient cells and
mouse brain
Christopher Holler, Georgia Taylor, Zachary McEachin, Qiudong Deng, William
Watkins, Kathryn Hudson, Charles Easley, William Hu, Chadwick Hales, Wilfried
Rossoll, Gary Bassell, Thomas Kukar (Atlanta/US)
09:21
DB30
Chloroquine rescues Cerebrospinal fluid progranulin deficiency in FTD
Daniel Bittner, Peter Körtvelyessy, Hans-Jochen Heinze, Mandy Busse, Stefan
Busse (Magdeburg/DE)
10:00–11:30
Room
Chairs
Session 9: Mechanisms of cell death
Lecture Hall
Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)
10:00
Insights on motor neuron degeneration in a mouse model of TDP-43 proteinopathy
Virigina Lee (Philadelphia, PA/US)
10:25
O16
Insights from iPSC and Drosophila Models of C9ORF72‐ Related ALS/FTD
Fen-Biao Gao (Worcester/US)
10:40
O17
Loss of TDP-43 Contributes to Non-coding RNA Mediated Toxicity
Elaine Liu, Jenny Russ, Edward Lee (Philadelphia/US)
38
ICFTD 2016
10:55
DB31
10:57
DB32
10:59
DB33
11:01
DB34
Fus regulates the transcriptome of the developing mouse brain through several
mechanisms
Chiara Valori (Tuebingen/DE), Cemil Kerimoglu (Göttingen/DE), Chieh-Yu Cheng,
Vignesh Sakthivelu (Tuebingen/DE), Ronald Naumann (Dresden/DE), Andre Fischer
(Göttingen/DE), Manuela Neumann (Tuebingen/DE)
Progranulin is neurotrophic in vivo, stimulating functional recovery after nerve crush
injury
Sander Beel, Louis De Muynck, Ludo Van Den Bosch, Wim Robberecht, Philip Van
Damme (Leuven, Belgium/BE)
C9orf72 differential expression in brain and monocytes suggests a possible role for
C9orf72 in monocyte function
Emily Lynes, Patrizia Rizzu, Ashutosh Dhingra, Melissa Castillo-Lizardo, Margherita
Franscescatto, Cornelis Blauwendraat, Sasja Heetveld, Elwira Pyz, Javier SimonSanchez, Matthis Synofzik, Peter Heutink (Tuebingen/DE)
RNA destabilization in frontotemporal lobar dementia and amyotrophic lateral
sclerosis
Hilary Archbold, Elizabeth Tank, Michelle Paulsen, Mats Ljungmann, Sami Barmada
(Ann Arbor/US)
11:05
Panel discussion: What is the toxic species for C9FTD/ALS?
Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)
11:30–13:30
Room
Postersession III - CBS, PSP, MND
Ballroom
P305
PLS-FTLD, expanding the spectrum of dementia in motor neuron disease
Michael van Es, Balint de Vries, Laura Rustemijer (Utrecht/NL), Anneke van der Kooi
(Amsterdam/NL), Joost Raaphorst (Amsterdam, Nijmegen/NL), Carin Schroder,
Tanja Nijboer, Joeren Hendrikse, Jan Veldink, Leonard van den Berg (Utrecht/NL)
P306
A voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) wholebrain analysis of gray matter and white matter changes in amyotrophic lateral
sclerosis (ALS) without dementia
Foteini Christidi, Efstratios Karavasilis, Sophia Xirou, Michael Rentzos, George
Velonakis, Vasiliki Zouvelou, Ioannis Zalonis, Panagiotis Ferentinos, Loukia Poulou,
Panagiotis Toulas, Thomas Zambelis, Nikolaos Karandreas, Nikolaos Kelekis,
Ioannis Evdokimidis (Athens, Greece/GR)
P307
Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron
disorders
Mary Kay Floeter, Rohan Katipally, Meridith Kim, Olivia Schanz, Matthew Stephen,
Laura Danielian, Tianxia Wu (Bethesda, MD/US), Edward Huey (New York, NY/US),
Avner Meoded (Bethesda, MD/US)
P308
Visuoperception test predicts pathologic diagnosis of Alzheimer disease in
corticobasal syndrome
Clara Boyd (New York, NY/US), Michael Tierney, Eric Wassermann (Bethesda,
MD/US), Salvatore Spina, Adrian Oblak, Bernardino Ghetti (Indianapolis, IN/US),
Jordan Grafman (Chicago, IL/US), Edward Huey (New York, NY/US)
39
ICFTD 2016
P309
Investigating progressive supranuclear palsy using VBM and SVM classification
Karsten Mueller (Leipzig/DE), Robert Jech, Cecilia Bonnet, Jaroslav Tintěra
(Prague/CZ), Harald E Möller (Leipzig/DE), Klaus Fassbender (Homburg/DE), Jan
Kassubek, Markus Otto (Ulm/DE), Evžen Růžička (Prague/CZ), Matthias L Schroeter
(Leipzig/DE)
P310
Genome-wide association study of plasma tau levels identifies risk variants for PSP
and CBD
Jin-Tai Yu, Jason Chen (San Francisco/US), Hui-Fu Wang (San Francisco/CN),
Henrik Zetterberg, Kaj Blennow (San Francisco/SE), Jennifer Yokoyama, Michael
Weiner, Joel Kramer, Howard Rosen, Bruce Miller, Giovanni Coppola, Adam Boxer
(San Francisco/US)
P311
The sequence of progression of symptom domains in the PSP-Rating Scale (PSPRS)
Claire Brittain (Windlesham/GB), Michael Irizarry (Windlesham/US), Jeremie Lebrec
(Windlesham/PT), Adam Boxer (San Francisco/US)
P312
Disentangling the neural correlates of corticobasal syndrome & corticobasal
degeneration with systematic & quantitative ALE meta-analyses
Franziska Albrecht, Sandrine Bisenius, Rodrigo Morales Schaack, Matthias
Schroeter (Leipzig/DE)
P313
Rapid progression of brain atrophy in progressive supranuclear palsy and
corticobasal degeneration
Shubir Dutt (San Francisco/US), Richard Binney (San Francisco, Philadelphia/US),
Hilary Heuer, Phi Luong, Suneth Attygalle, Priyanka Bhatt, Gabe Marx, Jonathan
Elofson (San Francisco/US), Maria Carmela Tartaglia (Toronto/CA), Irene Litvan (San
Diego/US), Scott McGinnis, Bradford Dickerson (Charlestown/US), John Kornak (San
Francisco/US), Dana Waltzman (San Francisco, Stanford/US), Lisa Voltarelli, Norbert
Schuff, Gil Rabinovici, Joel Kramer (San Francisco/US), Clifford Jack
(Rochester/US), Bruce Miller, Adam Boxer (San Francisco/US)
P314
Cerebrospinal Fluid Phosphorylated Tau Associated with Survival in 4-Repeat
Tauopathies
Kim Firn, Leslie M. Shaw, David J. Irwin, Murray Grossman, Corey T. McMillan
(Philadelphia/US)
P315
The relationship of iron accumulation to motor and cognitive performance
in amyotrophic lateral sclerosis
Nicola Spotorno, Julio Acosta-Cabronero, Judith Machts, Susanne Abdulla
(Magdeburg/DE), Katja Kollewe, Susanne Preti (Hannover/DE), Stefan Vielhaber,
Peter J. Nestor (Magdeburg/DE)
P316
Revised Clinical Diagnostic Criteria for Progressive Supranuclear Palsy (PSP)
Günter Höglinger, Gesine Respondek (Munich/DE), Maria Stamelou (Neurology/GR),
Carolin Kurz (Munich/DE), Keith Josephs (Rochester/US), Anthony Lang
(Toronto/CA), Brit Mollenhauer (Kassel/DE), Ulrich Müller (Giessen/DE), Christer
Nilsson (Lund/SE), Jennifer Whitwell (Rochester/US), Thomas Arzberger
(Munich/DE), Ellen Gelpi (Barcelona/BE), Armin Giese (Munich/DE), David Irwin
(Philadelphia/US), Wassilios Meissner (Bordeaux/FR), Alexander Pantelyat
(Baltimore/US), John van Swieten (Rotterdam/NL), Claire Troakes (London/GB),
Angelo Antonini (Venice/IT), Kailash Bhatia (London/GB), Yvette Bordelon (Los
Angeles/US), Jean Christophe Corvol (Paris/FR), Carlo Colosimo (Roma/IT), Richard
Dodel (Marburg/DE), Murray Grossman (Philadelphia/US), Jan Kassubek (Ulm/DE),
Florian Krismer (Innsbruck/AT), Johannes Levin (Munich/DE), Huw Morris
40
ICFTD 2016
(London/GB), Peter Nestor (Magdeburg/DE), Wolfgang Oertel (Marburg/DE), Gil
Rabinovici (San Francisco/US), James Rowe (Cambridge/GB), Thilo van Eimeren
(Cologne/DE), Gregor Wenning (Innsbruck/AT), Jin-Tai Yu (San Francisco/US),
Lawrence I. Golbe (New Brunswick/US), Irene Litvan (San Diego/US), Adam Boxer
(San Francisco/US)
P317
Whole-brain pattern of iron-aware tissue magnetostatics in amyotrophic lateral
sclerosis
Julio Acosta-Cabronero, Judith Machts (Magdeburg/DE), Katja Kollewe
(Hannover/DE), Susanne Abdulla (Magdeburg/DE), Susanne Petri (Hannover/DE),
Stefan Vielhaber, Peter Nestor (Magdeburg/DE)
P318
PROGRESSIVE SUPRANUCLEAR PALSY IN THE SPECTRUM OF
FRONTOTEMPORAL DEMENTIA: A NEUROPSYCHOLOGICAL AND
NEUROIMAGING STUDY
Leonardo Cruz de Souza, Elisa de Paula França Resende, Francisco Eduardo Costa
Cardoso, Henrique Cerqueira Guimarães, Leandro Boson (Belo Horizonte/BR),
Michael Hornberger, Maxime Bertoux (Norwich/GB), Paulo Caramelli, Antônio Lúcio
Teixeira (Belo Horizonte/BR)
P319
H46R SOD1 mutation is consistently associated with a relatively benign form of
Amyotrophic Lateral Sclerosis with very slow progression
Zhangyu Zou (Fuzhou/CN), Mingsheng Liu, Xiaoguang Li, Liying Cui (Beijing/CN)
P320
Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS
patients of Chinese origin
Zhangyu Zou (Fuzhou/CN), Xiaoguang Li, Mingsheng Liu, Liying Cui (Beijing/CN)
P321
Predicting Disease Progression in Progressive Supranuclear Palsy in Multicenter
Clinical Trials
Jee Bang, Iryna Lobach (San Francisco/US), Anthony Lang (Toronto/CA), Murray
Grossman (Philadelphia/US), David Knopman (Rochester/US), Bruce Miller (San
Francisco/US), Lon Schneider (Los Angeles/US), Rachelle Doody (Houston/US),
Andrew Lees (London/GB), Michael Gold (Research Triangle/US), Bruce Morimoto
(Lincoln/US), Adam Boxer (San Francisco/US)
P322
Unusual sporadic 4R-tauopathy with bulbar onset MND-like syndrome preceding
bvFTD
Johannes Prudlo, Stefan Teipel, Andreas Buettner (Rostock/DE), Manuela Neumann
(Tuebingen/DE)
P323
TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in
behavioral variant frontotemporal dementia
Rachel Tan (Randwick, Sydney/AU), Matthew Kiernan, Jillian Kril (Sydney/AU),
Masato Hasegawa, Masami Masada-Suzukake (Japan/JP), Carol Dobson-Stone,
John Kwok (Randwick, Sydney/AU), Michael Hornberger (Norwich/GB), John
Hodges, Glenda Halliday (Randwick, Sydney/AU)
P324
Loosing words and hand! A rare case of Semantic Dementia overlapping with
Corticobasal Syndrome.
Noémie MOREAU (Aix en Provence/FR), Marie LEGRAND (Pertuis/FR), Charlotte
ROSEAU (Aix en Provence/FR), Guillaume PUIGSERVER (Pertuis/FR), Laurent
RENIE, Bernadette BONNEFOI (Aix en Provence/FR)
41
ICFTD 2016
P325
Natural history and progression to dementia in progressive supranuclear palsy
Andrea Pilotto (Brescia, Italy, Tuebingen, Germany/IT), Stefano Gazzina, Alberto
Benussi, Marta Manes, Valentina Dell'Era, Maura Cosseddu, Rosanna Turrone,
Barbara Borroni, Alessandro Padovani (Brescia, Italy/IT)
P326
DESCRIPTION OF PROGRESSIVE SUPRANUCLEAR PALSY SUBTYPES FROM
THE NAVARRA BRAIN BANK
Javier Sánchez Ruiz de Gordoa, María Victoria Zelaya Huerta, Teresa Tuñon
Álvarez, Federico García Bragado, María Teresa Mendioroz Iriarte, Valle Coca
Pueyo, Elena Erro Aguirre (Pamplona/ES)
P327
Joint analysis of GWAS with epigenetic data revealed candidate markers in
FTD/MND, and convergence in pathways
Erdogan Taskesen, Aniket Mishra, Danielle Posthuma, Yolande Pijnenburg
(Amsterdam/NL)
P328
Multiple Pathologies and Heterogeneity in Corticobasal Syndrome and Corticobasal
Degeneration: complications in a complex disease
Rodrigo A. Santibanez (Vancouver, Santiago/CA), Ian R. Mackenzie, Michael
Marnane, Shervin Mortazavi, Connor Keller, Jennifer Li, Angela Kim, Ging-Yuek R.
Hsiung (Vancouver/CA)
P329
Disease-Specific Relationship Between Cerebrospinal Fluid & Longitudinal
Neuroimaging
Charles Jester, Kim Firn, Kylie Ternes, Leslie M Shaw, David Irwin, Dan Weintraub,
Murray Grossman, Corey McMillan (Philadelphia/US)
P330
Creutzfeldt Jakob Disease (CJD) and Supranuclear Palsy (PSP) in one patient - two
sides of the same medal?
Felix Mueller-Sarnowski, Wiebke Valentin, Janine Diehl-Schmid (Munich/DE)
P331
The Edinburgh Cognitive and Behavioural ALS Screen (ECAS); the effect of age,
education, and IQ.
Monica Mariana De Icaza Valenzuela, Thomas Bak, Suvankar Pal, Sharon
Abrahams (Edinburgh/GB)
P332
Serum neurofilament light chain (NfL) in Progressive Supranuclear Palsy (PSP)
Laura Donker Kaat, Lieke Meeter, Agnita Boon, Wan Zeng Chiu, John van Swieten
(Rotterdam/NL)
P333
Neuropathologic and Neurobiologic Characterization of Early Onset Amyotrophic
Lateral Sclerosis Associated with a Novel TDP43 S375G Variant
Kathy Newell (Kansas City/US), Bernardino Ghetti, Jill Murrell (Indianapolis/US),
Maurizio Romano, Elisa Salis, Christiana Stuani, Emanuele Buratti (Trieste/IT)
P334
Social Cognition in Amyotrophic Lateral Sclerosis in an Argentinean-cohort.
Preliminary Data.
Federico Exequiel Nahas (Ciudad Autonoma de Buenos Aires, Buenos Aires/AR),
Bruno De Ambrosi, Ismael Calandri, Fernanda Tapajoz, Patricia Zanuso, Martin
Nogues (Ciudad Autonoma de Buenos Aires/AR), Ricardo Allegri (Ciudad Autonoma
de Buenos Aires, Buenos Aires/AR)
42
ICFTD 2016
P335
Measuring Clinical and Cognitive Decline in CBD and PSP for Multicenter Clinical
Trials – the 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI)
Dan Luong, Lisa Voltarelli, Hilary Heuer, John Kornak (San Francisco/US), Kimiko
Domoto-Reilly, Bradford Dickerson (Boston/US), Irene Litvan (San Diego/US), Maria
Carmela Tartaglia (Toronto/CA), Bruce Miller, Adam Boxer (San Francisco/US)
11:30–13:30
Room
Postersession III - Blood and Imaging biomarkers
Ballroom
P336
IDENTIFYING CORTICAL ATROPHY IN THE MAIN VARIANTS OF FRONTOTEMPORAL DEMENTIA, IN 48 COLOMBIAN PATIENTS: A VBM ANALYSIS
Pablo Reyes, Maria Ortega, Santiago Gutierrez, Hernando Santamaría-García,
Felipe Uriza, Diana Matallana (Bogotá/CO)
P337
The diffuse not focal frontal atrophy subtype shows worse prognosis in behavioral
Jin San Lee (Seoul/KR), Na-Yeon Jung, Eun-Joo Kim (Busan/KR), Juyoun Lee
(Daejeon/KR), Young Kyoung Jang, Yeo Jin Kim, Hee Jin Kim, Sang Won Seo, JaeHong Lee (Seoul/KR), Byeong C. Kim (Gwangju/KR), Kyung-Won Park (Busan/KR),
Soo Jin Yoon (Daejeon/KR), Jee H. Jeong (Seoul/KR), Sang Yun Kim
(Seongnam/KR), Key-Chung Park (Seoul/KR), David S. Knopman (Rochester/US),
Duk L. Na (Seoul/KR)
P338
Tau imaging in patients with ALS/PDC in the Kii Peninsula
YASUMASA KOKUBO (Tsu/JP), Hitoshi Shinotoh, Hitoshi Shimada, Fumitoshi Niwa
(Chiba/JP), Ryogen Sasaki, Satoru Morimoto (Tsu/JP), Hironobu Endo, Soichiro
Kitamura, Shigeki Hirano (Chiba/JP), Ikuko Aiba (Nagoya/JP), Masanori Miyamura
(Ise/JP), Naruhiko Sahara (Chiba/JP), Shigeki Kuzuhara (Suzuka/JP), Makoto
Higuchi, Tetsuya Suhara (Chiba/JP)
P339
Analysis of regional MRI volumes and thicknesses on frontotemporal dementia
patients with C9ORF72 expansion
Ramona Haanpää, Yawu Liu, Anette Hall, Päivi Hartikainen (Kuopio/FI), Virpi
Moilanen (Oulu/FI), Hilkka Soininen, Anne Remes (Kuopio/FI)
P340
Brain network organization in frontotemporal dementia across countries, recordings
and methods
Lucas Sedeño (BUENOS AIRES/AR), Olivier Piguet (Sydney/AU), Adolfo García, Sol
Fitipaldi, Sofía Abrevaya, Indira García-Cordero, Sandra Baez, Laura Alethia de la
Fuente (BUENOS AIRES/AR), Fiona Kumfor (Sydney/AU), Teresa Torralva
(BUENOS AIRES/AR), John Hodges (Sydney/AU), Agustin Ibanez (BUENOS
AIRES/AR)
P341
Frontotemporal dementia and language networks: cortical thinning is driven by
dyslexia susceptibility genes
Marta Antonia Manes, Donata Paternicò (Brescia/IT), Enrico Premi (Brescia/JM),
Maura Cosseddu, Stefano Gazzina, Antonella Alberici (Brescia/IT), Silvana Archetti,
Elisa Bonomi (Brescia,Italy/IT), Maria Sofia Cotelli, Marinella Turla, Maria Cotelli
(Brescia, Italy/IT), Anna Micheli (Bergamo, Italy/IT), Roberto Gasparotti (Brescia,
Italy/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT)
43
ICFTD 2016
P342
A novel approach to investigate a rare Frontotemporal Disorder: proteomic studies
about Nasu-Hakola Disease.
Anna Maria Agresta, Antonella De Palma, Dario Di Silvestre (Segrate (Milan)/IT),
Anna Maria Bardoni, Roberta Salvini, Paolo Iadarola (Pavia/IT), Pier Luigi Mauri
(Segrate (Milan)/IT)
P343
Evolution of Cerebral PET Glucose Metabolism from presymptomatic to symtomatic
Frontotemporal Dementia Linked to Chromosome 3 (FTD-3) – a voxel based SPM
Analysis
Peter Johannsen, Ian Law, Christian Hansen, Peter Roos, Jette Stokholm
(Copenhagen/DK), Adrian M. Isaacs (London/GB), Jerry Brown (Cambridge/GB),
Jorgen E. Nielsen (Copenhagen/DK)
P344
Tau [18F]AV-1451 PET Uptake in Patients with Suspected 4-Repeat Tauopathy
Corey McMillan (Philadelphia/US), Daniel Schonhaut (San Francisco/US), David
Russell (New Haven, CT/US), Adam Boxer (San Francisco/US), Irene Litvan (San
Diego/US), Erik Roberson (Birmingham, AL/US), Ilya Nasrallah, Andrew Siderowf,
Michael Devous, Murray Grossman (Philadelphia/US), Gil Rabinovici (San
Francisco/US)
P345
In genetic frontotemporal dementia, functional network efficiency is maintained until
the onset of symptoms: evidence for functional resilience to structural change
Timothy Rittman, Robin Borchert, Simon Jones (Cambridge/GB), John Van Swieten
(Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberta (Milan/IT), Mario
Marsellis (Toronto/CA), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT),
Giovanni Frisoni (Geneva/CH), Robert La Force (Quebec/CA), Elizabeth Finger
(London/CA), Alexandre Mendonça (Lisbon/PT), Sandro Sorbi (Florence/IT),
Jonathan Rohrer (London/GB), James Rowe (Cambridge/GB), on behalf of the
Genetic FTD Initiative (GENFI) (London/GB)
P346
Disease-specific patterns of cortical and subcortical degeneration in a longitudinal
study of Alzheimer's disease and behavioural-variant frontotemporal dementia
Ramon Landin-Romero, Fiona Kumfor, Cristian Leyton, Muireann Irish, John Hodges,
Olivier Piguet (Sydney/AU)
P347
White matter changes in frontotemporal dementia and the C9ORF72 gene
expansions
Ramon Landin-Romero (Sydney/AU), Bonnie Yin Ka Lam (Hong Kong/HK), Fiona
Kumfor, Emma Devenney, Lauren Bartley, Glenda Halliday, John Hodges, Olivier
Piguet (Sydney/AU)
P348
The synaptic protein neurogranin as a clinical CSF biomarker in the diagnosis of FTD
Alexander Santillo, Shorena Janelidze, Joakim Hertze (Malmö/SE), Henrik Zetterberg
(Mölndal/SE), Maria Landqvist Waldö (Lund/SE), Kaj Blennow (Mölndal/SE), Oskar
Hansson (Malmö/SE)
P349
Different binding behavior of the Tau-PET tracer [F-18]-AV-1451 in AD and Taupositive FTLD
Jochen Hammes (Cologne/DE), Gérard N Bischof (Cologne, Jülich/DE), Klaus
Fliessbach (Bonn/DE), Kathrin Giehl, Frank Jessen, Bernd Neumaier, Juraj Kukolja,
Özgür Onur, Alexander Drzezga (Cologne/DE), Thilo van Eimeren (Cologne,
Jülich/DE)
P350
Transcriptome analysis in FTD patients: genes, pathways and networks
Wouter De Coster, Sara Van Mossevelde, Sebastiaan Engelborghs (Antwerp/BE),
Mathieu Vandenbulcke (Edegem/BE), Ligia Mateiu, Maria Mattheijssens, Karin
44
ICFTD 2016
Peeters (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Patrick Cras (Antwerp,
Edegem/BE), Peter Paul De Deyn (Antwerp, Groningen/BE), Marc Cruts, Christine
Van Broeckhoven (Antwerp/BE)
P351
Neural network organization in frontotemporal degeneration by means of graph
theory on resting-state EEG recordings: a study on behalf of the Italian FTD Network
Laura Bonanni, Raffaella Franciotti (Chieti/IT), Alberto Benussi (Brescia/IT), Marco
Bozzali (Rome/IT), Annachiara Cagnin (Padua/IT), Amalia Bruni (Lamezia Terme/IT),
Silani Vincenzo (Milan/IT), Giancarlo Logroscino (Bari/IT), Roberta Ghidoni
(Brescia/IT), Benedetta Nacmias (Florence/IT), Fabrizio Tagliavini (Milano/IT),
Alessandro Padovani (Brescia/IT), Marco Onofrj (Chieti/IT), Daniela Galimberti
(Milan/IT), Barbara Borroni (Brescia/IT)
P352
Characteristics and Progress on the Initial 256 Participants in the Advancing
Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL) North
American Rare Disease Clinical Research Consortium
Adam Boxer, Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Hilary
Heuer, Samara Laxineta (San Francisco/US), Murray Grossman (Philadelphia/US),
Giovanni Coppola (Los Angeles/US), Bradford Dickerson (Cambridge, MA/US),
Yvette Bordelon (Los Angeles/US), Robin Conwit (Bethesda/US), Christina Dheel
(Rochester/US), Kelley Faber (Indianapolis, IN/US), Howard Feldman
(Vancouver/CA), John Ferguson (Bethesda/US), Julie Fields (Rochester/US), Jamie
Fong (San Francisco/US), Tatania Foroud (Indianapolis, IN/US), Wendy Galpern
(Washington, DC/US), Nupur Ghoshal (St. Louis/US), Neill Graff-Radford
(Jacksonville, FL/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US),
David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Daniel Kaufer (Chapel
Hill/US), Anna Karydas (San Francisco/US), Alex Klein (New York/US), David
Knopman (Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter
Kukull (Seattle/US), Irene Litvan (San Diego/US), Ian Mackenzie (Vancouver/CA),
Mario Mendez (Los Angeles, Baltimore, MD/US), Bruce Miller (San Francisco/US),
Matthew Miller (Rochester/US), Chiadi Onyike, Alexander Pantelyat (Baltimore,
MD/US), Rosa Rademakers (Jacksonville, FL/US), Erik Roberson (Jacksonville, FL,
Birmingham/US), Margaret Sutherland (Bethesda/US), Maria Carmela Tartaglia
(Toronto/CA), Nadine Tatton (Radnor, PA/US), Arthur Toga (Los Angeles/US),
Ashley Vetor (Indianapolis, IN/US), Sandra Weintraub (Chicago/US), Zbigniew
Wszolek (Jacksonville, FL/US)
P353
Grey Matter Disease Distributions in a Colombian Cohort of Patients with
Pablo Reyes (Bogota/CO), Hernando Santamaría-Garcia (Bogota, Bogotá/CO),
Felipe Uriza, Angela Martinez (Bogota/CO), Angela Iragorri, Diana Matallana, Jose
Santacruz, Carlos Cano (Bogota, Bogotá/CO), Katya Rascovsky, Corey MacMillan,
Murray Grossman (Philadelphia, PA/US)
P354
EEG dominant frequency peak differentiates between Alzheimer’s disease and
frontotemporal lobar degeneration.
Joery Goossens (Antwerp/BE), Jorne Laton, Jeroen Van Schependom, Jeroen
Gielen (Brussels/BE), Hanne Struyfs, Sara Van Mossevelde, Tobi Van den Bossche,
Johan Goeman, Peter Paul De Deyn, Anne Sieben, Jean-Jacques Martin, Christine
Van Broeckhoven, Julie van der Zee (Antwerp/BE), Guy Nagels (Brussels/BE),
Sebastiaan Engelborghs (Antwerp/BE)
P355
The sAPPβ/YKL-40 ratio in cerebrospinal fluid as a novel diagnostic marker in
frontotemporal lobar degeneration-related syndromes: a multicentre study
Daniel Alcolea, Eduard Vilaplana, Marc Suárez-Calvet, Rafael Blesa, Jordi Clarimon
(Barcelona, Madrid/ES), Albert Lladó, Raquel Sánchez-Valle, José L. Molinuevo
45
ICFTD 2016
(Barcelona/ES), Guillermo García-Ribas (Madrid/ES), Yaroslau Compta, María José
Martí (Madrid, Barcelona/ES), Gerard Piñol-Ripoll (Lleida/ES), Guillermo AmerFerrer, Aina Noguera, Ana García-Martín (Palma de Mallorca/ES), Juan Fortea,
Alberto Lleó (Barcelona, Madrid/ES)
P356
CSF exploratory biomarker study for (differential) diagnosis of frontotemporal lobar
degeneration.
Joery Goossens, Julie van der Zee (Antwerp/BE), Sara Van Mossevelde (Antwerp,
Edegem/BE), Eugeen Vanmechelen (Ghent/BE), Tobi Van den Bossche (Antwerp,
Edegem/BE), Bart De Vil, Anne Sieben, Jean-Jacques Martin (Antwerp/BE), Patrick
Cras (Edegem, Antwerp/BE), Johan Goeman, Peter Paul De Deyn, Christine Van
Broeckhoven, Sebastiaan Engelborghs (Antwerp/BE)
P357
Dynamic connectivity state oscillations in presymptomatic GRN disease: from
Connectome to Chronnectome.
Enrico Premi (Brescia/JM), Matteo Diano (Turin/IT), Stefano Gazzina (Brescia/IT),
Franco Cauda (Turin/IT), Silvana Archetti, Roberto Gasparotti, Alessandro Padovani,
Barbara Borroni (Brescia/IT)
P358
Structural deficits and altered network connectivity in presymptomatic C9ORF72
Suzee Lee, Ana C. Sias, Maria Luisa Mandelli, Jesse A. Brown, Alainna B. Brown
(San Francisco/US), Anna M. Khazenzon (Stanford/US), Anna A. Vidovszky,
Theodore P. Zanto, Anna M. Karydas (San Francisco/US), Mochtar Pribadi, Giovanni
Coppola, Dan H. Geschwind (Los Angeles/US), Rosa Rademakers (Jacksonville/US),
Maria Luisa Gorno-Tempini, Howard J. Rosen, Bruce L. Miller, William W. Seeley
(San Francisco/US)
P359
Longitudinal decline of cerebral glucose metabolism in Frontotemporal Lobar
Degeneration Continuum
Alexandre Bejanin, Nagehan Ayakta, Daniel R Schonhaut, Gabe Marx, Gautam
Tammewar, Yann Cobigo, Faye McKenna, Leonardo Iaccarino, Marilu GornoTempini, Bruce L. Miller, William J. Jagust, Howard J. Rosen, Gil D. Rabinovici (San
Francisco/US)
P360
Serum neurofilament light chain protein is a measure of disease intensity in
Ione Woollacott, Jonathan Rohrer, Katrina Dick, Emilie Brotherhood, Elizabeth
Gordon, Alexander Fellows, Jamie Toombs, Ronald Druyeh, M. Jorge Cardoso,
Sebastien Ourselin, Jennifer Nicholas (London/GB), Niklas Norgren (Umea/SE),
Simon Mead (London/GB), Ulf Andreasson, Kaj Blennow (Gothenburg/SE), Jonathan
Schott, Nick Fox, Jason Warren (London/GB), Henrik Zetterberg (London,
Gothenburg/SE)
P361
Default, salience, and executive control network functional connectivity changes in
behavioural variant FTD and Alzheimer’s disease
Juan Wang, Adeline Ng, Joseph Lim, Boon Linn Choo, Christabel See, Levinia Lim,
Ting Ting Yong, Russell Chander, Heidi Foo, Angeline Zhang, Joanna Su, Ashwati
Vipin, Simon Ting, Shahul Hameed, Nagaendran Kandiah, Helen Zhou
(Singapore/SG)
P362
Principal Component Analysis of [18F]-AV-1451 Tau PET in Alzheimer Disease and
Karl Friedrichsen, Shruti Mishra, Nupur Ghoshal, Brian Gordon, Nelly JosephMathurin, Yi Su, Jon Christensen, Patricia Aldea, Jon McConathy, Beau Ances, Nigel
Cairns, John Morris, Tammie Benzinger (Saint Louis/US)
46
ICFTD 2016
P363
Grey matter network differences between behavioural variant Frontotemporal
Dementia and Alzheimer’s disease
Everard Vijverberg (Amsterdam, The Hague/NL), Betty Tijms, Joana Dopp, Yun
Jeong Hong, Philip Scheltens, Frederik Barkhof, Yolande Pijnenburg
(Amsterdam/NL)
P364
The REGISTRY FOR EARLY-ONSET DEMENTIA AND CAREGIVERS IN HONG
KONG (REACH) study – clinical characteristics of FTD patients in Hong
Kong
Bonnie Yin Ka Lam, Lisa Wing Chi Au, Adrian Wong, Valerie Wong, Lorraine Law, Liz
Yuen, Vincent Chung Tong Mok (Hong Kong/HK)
P365
Distinct subcortical atrophy patterns across four different neurodegenerative
syndromes
Julia Neitzel, Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo Grimmer,
Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE), Kathrin Finke,
Christian Sorg (Munich/DE)
P366
Testing the network degeneration hypothesis for intrinsic brain networks and four
distinct neurodegenerative syndromes
Julia Neitzel (Munich/DE), Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo
Grimmer, Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE),
Kathrin Finke, Christian Sorg (Munich/DE)
P367
Neurofilament light chain: a biomarker for disease onset and survival in genetic
Lieke Meeter, Elise Dopper, Lize Jiskoot (Rotterdam/NL), Raquel Sanchez-Valle
(Barcelona/ES), Caroline Graff (Stockholm/SE), Luisa Benussi, Roberta Ghidoni
(Brescia/IT), Yolande Pijnenburg (Amsterdam/NL), Barbara Borroni (Brescia/IT),
Daniela Galimberti (Milano/IT), Robert Jr Laforce (Québec/CA), Mario Masellis
(Toronto/CA), Rik Vandenberghe (Leuven/BE), Isabelle Le Ber (Paris/FR), Markus
Otto (Ulm/DE), Rick van Minkelen, Janne Papma (Rotterdam/NL), Serge Rombouts
(Leiden/NL), Mircea Balasa (Barcelona/ES), Linn Öijerstedt, Vesna Jelic
(Stockholm/SE), David Cash, Sophie Harding, M Jorge Cardoso, Sebastien Ourselin,
Katrina Dick, Martin Rossor (London/GB), Giuliano Binetti, Alessandro Padovani
(Brescia/IT), Elio Scarpini, Chiara Fenoglio (Milano/IT), Carmela Tartaglia
(Toronto/CA), Foudil Lamari (Paris/FR), Christian Barro, Jens Kuhle (Basel/CH),
Jonathan Rohrer (London/GB), Charlotte Teunissen (Amsterdam/NL), John van
Swieten (Rotterdam, Amsterdam/NL)
P368
Novel CSF biomarkers discriminating FTLD-TDP from non-demented controls.
Marta del Campo, Naura Elias, Marleen Koel-Simmelink, Lynn Boonkamp
(Amsterdam/NL), Daniela Galimberti (Milan/IT), William Hu (Atlanta/US), Charlotte
Teunissen (Amsterdam/NL)
P369
Analysis of Frontotemporal Lobar Degeneration Patients Using Automated Magnetic
Resonance Imaging Analyzing Tool: The MRI Characteristics of C9ORF72 Expansion
Carriers
Antti Cajanus, Anette Hall, Yawu Liu (Kuopio/FI), Timo Urhemaa, Juha Koikkalainen
(Tampere/FI), Daniel Rueckert (London/GB), Steen Hasselbalch (Copenhagen/DK),
Patrizia Mecocci (Perugia/IT), Wiesje van der Flier (Amsterdam/NL), Hilkka Soininen
(Kuopio/FI), Jyrki Lötjönen (Tampere/FI), Anne Remes (Kuopio/FI)
47
ICFTD 2016
P370
Accelerated Structural Gray Matter and White Matter Changes in Preclinical
Progranulin Mutation Carriers
Christopher Olm, Corey McMillan, David Irwin, Vivianna Van Deerlin, James Gee,
Murray Grossman (Philadelphia/US)
P371
Local thalamic atrophy in behavioural variant FTD
Alexander Santillo (Malmö/SE), David Jakabek (Wollongong/AU), Mark Walterfang
(Melbourne/AU), Karin Nilsson, Danielle van Westen (Lund/SE), Jeffrey Looi
(Canberra/AU), Brian Power (Fremantle/AU)
P372
STRUCTURAL BRAIN IMAGING DIFFERENTIATES BEHAVIORAL VARIANT OF
FRONTOTEMPORAL DEMENTIA FROM LATE LIFE DEPRESSION
Duygu Tosun, Howard Rosen, Jessica Zakrzewski, Bruce Miller, Joel Kramer,
Michael Weiner, Owen Wolkowitz, Craig Nelson, Scott Mackin (San Francisco/US)
P373
DIAGNOSTIC UTILITY OF ARTERIAL SPIN LABELED MAGNETIC RESONANCE
IMAGING AND FLOURODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY
IN THE BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA AND
ALZHEIMER’S DISEASE
Duygu Tosun, Norbert Schuff, Gil Rabinovici, Nagehan Ayakta, Bruce Miller (San
Francisco/US), William Jagust (Berkeley/US), Joel Kramer, Michael Weiner, Howard
Rosen (San Francisco/US)
P374
Replication of pathology-confirmed atrophy patterns via cortical thickness analysis in
dementia
Jee Hoon Roh, Jihye Hwang, Chan Mi Kim, Sohee Park, Jae-Hong Lee (Seoul/KR)
P375
Neuroanatomic and Neuropsychological Evidence of Cognitive Reserve in the ALSFTD spectrum
Katerina Placek, Kylie Ternes, Lauren Massimo, John Woo, Lauren Elman, David
Irwin, Murray Grossman, Corey T. McMillan (Philadelphia/US)
P376
Alteration of the brain morphometry and metabolism following donepezil treatment in
Alzheimer's disease: VBM with DARTEL and 1H-MR spectroscopy
Gwang-Woo Jeong, Choong-Man Mooon (Gwang-Ju/KR)
P377
Progranulin plasma levels predict the presence of GRN mutations but not the
development of symptoms
Daniela Galimberti, Chiara Fenoglio, Sara Cioffi, Giorgio Fumagalli, Andrea Arighi
(Milan/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT), Fabrizio Tagliavini
(Milan/IT), Mario Masellis, Carmela Tartaglia (Toronto/CA), John Van Swieten, Lieke
Meeter (Rotterdam/NL), Caroline Graff (Stockholm/SE), Alexandre Mendonca
(Lisbon/PT), Jonathan Rohrer (London/GB), Elio Scarpini (Milan/IT), on behalf of the
Genetic Initiative (GENFI) (London/GB)
P378
Regional differences in FDG-PET uptake in asymptomatic FTD patients with GRN
and C9ORF72 mutations
Karteek Popuri, Mahadev Bhalla, Adrienne Buller, Sohrab Towfighi (Burnaby/CA),
Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers
(Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), GingYuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)
P379
Network measures of glucose metabolism are altered in asymptomatic FTD subjects
Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers
48
ICFTD 2016
(Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), GingYuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)
P380
Network-level analysis of cortical gray matter atrophy in asymptomatic FTD subjects
Pheth Sengdy (Vancouver/CA), Rosa Rademakers (Jacksonville/US), Howard
Feldman, Ging-Yuek Hsiung (Vancouver/CA), Lei Wang (Chicago/US), Ian R
Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)
P381
Distinct patterns of brain atrophy in genetic frontotemporal dementia: visual rating
scales in the GENFI cohort
Giorgio Giulio Fumagalli, Paola Basilico (Milan/IT), Sophie Harding (London/GB),
Andrea Arighi (Milan/IT), Martina Bocchetta (London/GB), Matteo Mercurio (Milan/IT),
Katrina Dick (London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni
(Brescia/IT), Caroline Graff (Stockholm/SE), Mario Masellis (Toronto/CA), Fabrizio
Tagliavini (Milan/IT), James Rowe (Cambridge/GB), Robert Laforce (Quebec/CA),
Elizabeth Finger (London Ontario/CA), Giovanni Frisoni (Brescia/IT), Alexandre
Mendoca (Lisbon/PT), Sandro Sorbi (Florence/IT), Elio Scarpini (Milan/IT), Jonathan
Rohrer (London/GB), Daniela Galimberti (Milan/IT)
P382
Comparison of diagnostic significance of voxel-based diffusion tensor imaging and
FDG-PET in bvFTD
Gero Lueg, Julia Julia Lange-Grumfeld, Alexis Vrachimis, Hubertus Lohmann,
Andreas Johnen, Thomas Duning (Münster/DE)
P383
Novel Connectome Approach Identifies Imaging-Genetic Associations in Sporadic
Radhika Madhavan (Bangalore/IN), Asha Singanamalli (Niskayuna/US), Rakesh
Mullick, Vivek Vaidya (Bangalore/IN), Chinnappa Kodira (Niskayuna/US), Vivianna
Van Deerlin, Murray Grossman, David Irwin, Corey McMillan (Philadelphia/US)
P384
Altered expression of non-coding RNAs in neural-derived serum exosomes in
patients with FTD
Chiara Fenoglio, Maria Serpente, Sara Cioffi, Marina Arcaro, Emanuela Oldoni,
Giorgio Fumagalli, Andrea Arighi, Paola Basilico, Alessandra Cattaneo, Laura
Porretti, Daniela Galimberti, Elio Scarpini (Milan/IT)
P385
Autosomal Dominant and sporadic Frontotemporal Lobar Degeneration: from noncoding RNAs to the identification of preclinical biomarkers and therapeutic targets
Maria Serpente, Chiara Fenoglio, Sara Cioffi, Marina Arcaro, Emanuela Oldoni,
Andrea Arighi, Giorgio Fumagalli, Elio Scarpini, Daniela Galimberti (Milan/IT)
P386
In vivo molecular imaging of beta-amyloid and tau aggregates in monozygotic twins
with discordant clinical phenotypes
Ryan Townley, David Jones, Bradley Boeve, David Knopman, Ronald Peterson, Val
Lowe, Clifford Jack (Rochester/US)
P387
CSF neurofilament-light chain and p-Tau180/t-Tau for discrimination of
frontotemporal lobar degeneration pathology subtypes
Julio Rojas, Carole Scherling, Anna Karydas, Joel Kramer, Howard Rosen, Gil
Rabinovici, Zachary Miller, Bruce Miller, Adam Boxer (San Francisco, CA/US)
P388
18F-AV-1451 in frontotemporal dementia spectrum disorders
Richard Tsai, Alexandre Bejanin (San Francisco/US), Daniel Schonhaut (San
Francisco, Berkeley/US), Rik Ossenkoppele (Amsterdam/NL), James O'Neil, Mustafa
Janabi, Suzanne Baker (Berkeley/US), Andreas Lazaris (San Francisco/US),
49
ICFTD 2016
Nagehan Ayakta, Gautam Tammewar (San Francisco, Berkeley/US), Marilu GornoTempini, Bruce Miller, Adam Boxer (San Francisco/US), William Jagust
(Berkeley/US), Gil Rabinovici (San Francisco, Berkeley/US)
P389
Differential Longitudinal Decline of White Matter Integrity in Frontotemporal Lobar
Degeneration and Alzheimer’s Disease
Gabriel Marx, Fanny Elahi, Howie Rosen (Oakland/US)
P390
Patient-tailored disease epicenters in behavioral variant frontal temporal dementia
and semantic variant primary progressive aphasia
Jesse Brown, Jersey Deng, Isabel Sible, Ana Sias, Suzee Lee, Marilu GornoTempini, Howard Rosen, Bruce Miller, William Seeley (San Francisco/US)
P391
Atlas-based volumetric MRI analysis of c9orf72 mutation carriers
Sonja Schönecker, Christiane Neuhofer, Janine Diehl-Schmid, Markus Otto,
Catharina Prix (Munich/DE), German FTLD-Consortium (Germany/DE), Bavarian
Brain Banking Alliance (Bavaria/DE), Thomas Arzberger, Dieter Edbauer, Berend
Feddersen, Thomas Klopstock, Johannes Levin (Munich/DE)
P392
Blood markers of neuroinflammation in frontоtemporal dementia
Nataliya Mikhaylova, Lubov Androsova, Svetlana Zozulya, Yana Fedorova, Igor
Kolykhalov, Tatiyana Kliushnik (Moscow/RU)
P393
Results from the Frontotemporal Lobar Degeneration Neuroimaging Initiative
(FTLDNI)
Howard Rosen (San Francisco/US), David Knopman (Rochester/US), Bradford
Dickerson (Boston/US), Brad Boeve (Rochester/US), Marissa Urbano, Alyssa
Caplan, Samara Laxineta, Bruce Miller (San Francisco/US)
P394
Decreased prefrontal cortex and posterior cingulate activation during matrix
reasoning in asymptomatic carriers of GRN mutations
Courtney Alexander (Hillsboro/US), Dasa Zeithamova (Eugene/US), Ging-Yuek R.
Hsiung, Ian Mackenzie (Vancouver/CA), Claudia Jacova (Hillsboro/US)
P395
Comparison of [18F]T807 PET regional retention patterns in FTLD-tau and FTLDTDP
Charles Burke, Namita Multani, Karen Misquitta, Pablo Rusjan, Alan Wilson, Sylvain
Houle, David Tang-Wai, Maria Carmela Tartaglia (Toronto/CA)
P396
Patterns of longitudinal neuroanatomical change in genetic FTD: results from the
Genetic FTD Initiative (GENFI)
Jonathan Rohrer, Martina Bocchetta, Elizabeth Gordon, David Cash, Katrina Dick,
David Thomas, Jennifer Nicholas, M Jorge Cardoso, Sebastien Ourselin
(London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT),
Daniela Galimberti (Milano/IT), Mario Masellis (Toronto/CA), Caroline Graff
(Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT), Robert
Laforce Jr (Quebec/CA), Elizabeth Finger (London Ontario/CA), Alexandre Mendonca
(Lisboa/PT), Sandro Sorbi (Firenze/IT), Martin Rossor (London/GB)
P397
A case of Wilson’s disease presenting with depression as the initial symptom.
Hyuk Chang, Hyunyoung Park, JinSung Cheong (Iksan/KR)
P398
A Patient with Frontotemporal Dementia Presenting with Unilateral Apraxia.
Hyunyoung Park, Hyuk Chang, JinSung Cheong (Iksan/KR)
50
ICFTD 2016
P399
DTI changes in individuals with Primary Progressive Aphasia
Daniel Preiß, Ornella Billette, Julio Acosta-Cabronero, Peter Nestor (Magdeburg/DE)
P400
Clinical, genetic and pathological stratification in frontotemporal dementia:
implications for clinical trial design.
Elizabeth Gordon, Martina Bocchetta, M. Jorge Cardoso, Sebastien Ourselin, Jason
D. Warren, Jonathan D. Rohrer (London/GB)
P401
Computational modelling of combined M/EEG in FTD: layer specific insights into
altered neurobiology during the auditory mismatch negativity.
Alexander Shaw, Laura Hughes, James Rowe (Cambridge/GB)
P402
Frailty correlates with insula hypometabolism and frontal cortex atrophy in bvFTD
Innocenzo Rainero, Martina Amanzio, Federico D'Agata, Antonello Galati, Sara
Palermo, Elisa Rubino, Milena Zucca, Lorenzo Pinessi, Giancarlo Castellano
(Turin/IT)
P403
Phenomenology and anatomy of abnormal behaviours in frontotemporal dementia as
measured by the Cambridge Behavioural Inventory
Elizabeth Gordon, Jason D. Warren, Jonathan D. Rohrer (London/GB)
P404
Alteration in plasma lipids in frontotemporal dementia
Woojin Kim, Eve Jary, Russell Pickford, Lauren Bartley, Olivier Piguet, John Hodges,
Glenda Halliday (Sydney/AU)
P405
[18F]AV1451 PET in frontotemporal dementia from a MAPT mutation
William Bevan-Jones, Thomas Cope, Luca Passamonti, Timothy Fryer, Young Hong,
Simon Jones, Jonathan Coles, Patricia Vazquez Rodriguez, Ajenthan
Surendranathan, Robert Arnold, Franklin Aigbirhio, John O'Brien, James Rowe
(Cambridge/GB)
P406
The Inverse Cingulate Island Sign in Hippocampal Sclerosis Dementia
Will Mantyh, David Knopman, Jonathan Graff-Radford (Rochester/US), Melissa
Murray, Dennis Dickson (Jacksonville/US), David Jones (Rochester/US)
P407
Serum neuron-specific enolase is increased in mild neurocognitive disorder / mild
cognitive impairment and related to white matter hyperintensities
Maryna Polyakova, Katrin Arelin, Leonie Lampe, Francisca Then, Tobias Luck,
Jürgen Kratzsch, Karl-Titus Hoffmann, Steffi Rieder-Heller, Arno Villringer, Peter
Schoenknecht, Matthias L. Schroeter (Leipzig/DE)
P408
Can Neuroimaging Measures of Hippocampal Structure Predict Alzheimer's vs. FTLD
Neuropathologies?
Lei Wang, Veronika Hanko, Kathryn Alpert, Julie Schneider, Konstantinos Arfanakis,
David Bennett (Chicago/US)
P409
[18F]AV1451 PET imaging in Semantic Dementia
William Bevan-Jones, Thomas Cope, Luca Passamonti, Patricia Vazquez Rodriguez,
Ajenthan Surendranathan, Robert Arnold, Simon Jones, Timothy Fryer, Young Hong,
Jonathan Coles, Franklin Aigbirhio, John O'Brien, James Rowe (Cambridge/GB)
P410
Presymptomatic changes in gray matter volume, white matter integrity and
neuropsychological assessment in C9orf72 mutation carriers
Jessica L. Panman (Rotterdam, Leiden/NL), Lize C. Jiskoot, Elise G.P. Dopper
(Rotterdam, Leiden, Amsterdam/NL), Serge A.R.B. Rombouts (Leiden/NL), Tom den
Heijer, Sanne Franzen (Rotterdam/NL), Yolande A.L. Pijnenburg (Amsterdam/NL),
51
ICFTD 2016
Rick van Minkelen, Janne M. Papma (Rotterdam/NL), John C. van Swieten
(Rotterdam, Amsterdam/NL)
P411
Tau PET, Amyloid PET, and Structural Imaging in Primary Progressive Aphasia
Adam Martersteck, M.-Marsel Mesulam, Emily Rogalski (Chicago/US)
P412
PET Tau Imaging with AV-1451 in N279K and S305N Microtubule Associated Protein
Tau (MAPT) Mutation Carriers Relative to Alzheimer’s Disease Dementia and
Controls
Brad Boeve, David Jones, Val Lowe, Heather Wiste, Matthew Senjem, Kejal Kantarci,
David Knopman, Christina Dheel (Rochester/US), Zbigniew Wszolek, Rosa
Rademakers (Jacksonville/US), Ronald Petersen, Clifford Jack, Jr. (Rochester/US)
P413
Neurofilament light chain protein concentration in CSF and atrophy are correlated in
bvFTD patients – Data from the multicentric FTLD consortium’s study
Sebastian Meyer, Karsten Mueller, Sandrine Bisenius (Leipzig/DE), Janine DiehlSchmid (Munich/DE), Hans Foerstl (Leipzig, Munich/DE), Klaus Fassbender
(Homburg/DE), Jan Kassubek, Bernhard Landwehrmeyer, Albert Christian Ludolph
(Ulm/DE), Johannes Kornhuber (Erlangen/DE), Johannes Prudlo (Rostock/DE), Anja
Schneider (Goettingen/DE), Katharina Stuke, Matthias Schroeter (Leipzig/DE)
P414
Evolution from the Asymptomatic to Symptomatic State in Familial FTD: Longitudinal
Neuropsychological and MRI Findings in Three MAPT Mutation Carriers
Christina Dheel, Scott Przybelski, Matthew Senjem, Kejal Kantarci, David Jones,
Julie Fields, Mary Machulda, Clifford Jack, Jr. (Rochester/US), Rosa Rademakers
(Jacksonville/US), David Knopman (Rochester/US), Zbigniew Wszolek
(Jacksonville/US), Ronald Petersen, Bradley Boeve (Rochester/US)
P415
Neurofilament light chain, progranulin, and S-100B in longitudinal serum samples of
patients with amyotrophic lateral sclerosis
Petra Steinacker, André Huss, Benjamin Mayer, Patrick Oeckl, Dorothée Lulé,
Jochen Weishaupt (Ulm/DE), Jens Kuhle (Basel/CH), Thomas Meyer (Berlin/DE),
Susanne Petri (Hannover/DE), Albert C. Ludolph, Markus Otto (Ulm/DE)
P416
Presymptomatic cerebral perfusion biomarker changes in genetic frontotemporal
dementia: results from the GENetic Frontotemporal dementia Initiative (GENFI)
Henk Mutsaerts, Saira Saeed Mirza (Toronto/CA), Jonathan Rohrer, David Thomas,
David Cash, Enrico De Vita, Katrina Dick, Sebastien Ourselin (London/GB), John van
Swieten (Rotterdam/NL), Daniela Galimberti (Milan/IT), James B. Rowe
(Cambridge/GB), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT),
Robert Laforce Jr (Quebec/CA), Elizabeth Finger (London/CA), Alexandre Mendonça
(Lisbon/PT), Jo Knight (Lancaster/GB), Bradley MacIntosh, Mario Masellis
(Toronto/CA)
P417
Decreased Global Field Synchronization (GFS) is an EEG classifier of frontotemporal
dementia
Vesna Jelic (Stockhom/SE), Per Östberg (Stockholm/SE), Lars-Olof Wahlund
(Stockhom/SE), Thomas Koenig (Bern/CH)
P418
Longitudinal Arterial Spin Labeling in the Behavioral Variant of Frontotemporal Lobar
Degeneration
Faye McKenna, Yann Cobigo, Gabe Marx, Suneth Attygale, Howard Rosen, Bruce
Miller (San Francisco, CA/US)
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ICFTD 2016
P419
longstanding Bipolar Affective Disorder and Behavioral Variant Frontotemporal
Dementia. Findings in Clinical and Neuroanatomical Phenotypic Patterns.
Francy Cruz Sanabria, Rodrigo Pardo Turriago, Diana Matallana Eslava, Pablo
Reyes Gavilán (Bogotá/CO)
P420
Cerebral glucose metabolism in C9orf72 mutation carriers
Timo Grimmer, Janine Diehl-Schmid, Igor Yakushev (Munich/DE), German FTLDConsortium (Ulm/DE)
P421
Increased neurofilament light chain correlates with decreased white matter integrity in
presymptomatic and symptomatic granulin carriers
Jessica L. Panman (Rotterdam, Leiden/NL), Lieke H.H. Meeter (Rotterdam/NL), Elise
G.P. Dopper, Lize C. Jiskoot (Rotterdam, Leiden, Amsterdam/NL), Mark J.M.J. Bouts,
Christiane Möller (Leiden/NL), Rick van Minkelen (Rotterdam/NL), Raquel SanchezValle, Mircea Balasa (Barcelona/ES), Caroline Graff, Linn Öijerstedt, Vesna Jelic
(Huddinge, Stockholm/SE), Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Borroni
Barbara, Alessandro Padovani (Brescia/IT), Daniela Galimberti, Elio Scarpini, Chiara
Fenoglio (Milan/IT), Robert Jr Laforce (Québec/CA), Rik Vandenberghe (Leuven/BE),
Isabelle Le Ber, Foudil Lamari (Paris/FR), Markus Otto (Ulm/DE), Jonathan D.
Rohrer, David M. Cash (London/GB), Serge A.R.B. Rombouts (Leiden/NL), Charlotte
E. Teunissen (Amsterdam/NL), Janne M. Papma (Rotterdam/NL), John C. van
Swieten (Rotterdam, Amsterdam/NL)
P422
Tau-PET imaging with THK-5351 in patients with clinically diagnosed progressive
supranuclear palsy
Sonja Schönecker, Matthias Brendel, Joachim Havla, Günter Höglinger, Kai Bötzel,
Adrian Danek, Axel Rominger, Johannes Levin (Munich/DE)
P423
Multivariate diagnostic approaches in Frontotemporal lobar degeneration - Data from
the german FTLDc
Sarah Straub (Ulm/DE), Matthias L. Schroeter (Leipzig/DE), Janine Diehl-Schmid,
Adrian Danek (Munich/DE), Christine v. Arnim (Ulm/DE), Lars Bertram (Berlin/DE),
Beate Einsiedler (Ulm/DE), Klaus Fassbender (Homburg/Saar/DE), Emily Feneberg
(Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Hans-Jürgen
Huppertz (Zurich/CH), Holger Jahn (Hamburg/DE), Frank Jessen (Cologne/DE),
Elisabeth Kasper (Rostock/DE), Jan Kassubek, Hans A. Kestler (Ulm/DE), Johannes
Kornhuber (Erlangen/DE), Christian Kubisch (Hamburg/DE), Bernhard
Landwehrmeyer (Ulm/DE), Martin Lauer (Würzburg/DE), Ludwig Lausser (Ulm/DE),
Christina M. Lill (Berlin/DE), Albert Ludolph (Ulm/DE), Manuel Maler (Erlangen/DE),
Rainer Muche, Elmar Pinkhardt (Ulm/DE), Johannes Prudlo (Rostock/DE), Lina Riedl
(Munich, Rostock/DE), Anja Schneider (Göttingen/DE), Robert Schomburg
(Homburg/Saar/DE), Stefan Teipel (Rostock/DE), Ingo Uttner (Ulm/DE), Alexander E.
Volk (Hamburg/DE), Markus Otto (Ulm/DE)
P424
Functional connectivity differences between behavioral-variant frontotemporal
dementia and early-onset Alzheimer's disease
Gabriel Castrillon (Medellin, Munich/CO), Lina Velilla, Margarita Giraldo, Alejandra
Zapata, Catalina bustamante, Francisco Lopera (Medellin/CO), Yakeel Quiroz
(Medellin, Boston/US)
P425
A mass spectrometry based search for biomarkers in FTD-PGRN
Diana Nijholt, Lieke Meeter, Lennard Dekker, Jeroen van Rooij, Theo M. Luider, John
van Swieten (Rotterdam/NL)
53
ICFTD 2016
11:30–13:30
Room
Postersession III - Mechanisms of cell death
Ballroom
P426
Cellular changes and toxicity in mouse neuronal cell cultures produced by the
cerebrospinal fluid from motor neuron disease patients.
Alida Spalloni, Michele Nutini (Roma/IT), Antonella Alberici, Barbara Borroni,
Alessandro Padovani (Brescia/IT), Patrizia Longone (Roma/IT)
P427
Simulation of Pathogenic Protein Spread in an Artificial Neural Network
Konstantinos Georgiadis, Selina Wray, S_x0013_ebastien Ourselin, Jason D.
Warren, Marc Modat (London/GB)
P428
Regulation of synaptic growth by Rab8, IK2/TBK1 and AKT, modifiers of
Sean Sweeney, Ryan West (York/GB)
P429
The C9ORF72 repeat expansion induces apoptosis by the DNA damage response
(DDR)
Julie Atkin (Sydney/AU)
P430
Prion-like properties of fragmented α-synuclein fibrils
Airi Tarutani, Genjiro Suzuki, Aki Shimozawa, Takashi Nonaka, Shin-ichi Hisanaga,
Masato Hasegawa (Tokyo/JP)
P431
Loss-of progranulin leads to early cell type-specific changes in lysosomes of
Progranulin knockout mice
Julia Götzl, Alessio-Vittorio Colombo, Fargol Mazaheri (Munich/DE), Scott Smith
(Boston/US), Katrin Fellerer (Munich/DE), Oleg Butovsky (Boston/US), Sabina
Tahirovic, Anja Capell, Christian Haass (Munich/DE)
P432
Role of Trem2 in Neurodegeneration: A systems biology approach
Fargol Mazaheri, Gernot Kleinberger, Anna Daria, Georg Werner, Sabina Tahirovic,
Dietrich Trümbach, Sebastian Bultmann (Munich/DE), Oleg Butovsky (Munich/US),
Christian Haass (Munich/DE)
P433
Disease model for GRN-linked FTLD using patient- and engineered stem cells.
Joke Terryn, Philip Van Damme, Catherine Verfaillie (Leuven/BE)
P434
Characterization of the expression and effects of C9ORF72 in cell-based models and
human brain
Stina Leskelä, Ville Juutilainen, Mari Takalo, Mikael Marttinen, Hilkka Soininen, Mikko
Hiltunen, Anne Remes, Annakaisa Haapasalo (Kuopio/FI)
P435
Expression and function of frontotemporal dementia gene C9ORF72 in neuronal cells
Stina Leskelä, Mari Takalo, Hilkka Soininen, Anne Remes, Mikko Hiltunen,
Annakaisa Haapasalo (Kuopio/FI)
P436
Modeling frontotemporal lobar degeneration using patient-specific iPSCs and iPSCderived cortical neurons
Julia Japtok, Arun Pal, Benedikt Kretner, Vitaly Zimyanin, Xenia Lojewski, Marcel
Naumann, Jared Sterneckert (Dresden/DE), Tobias M. Boeckers (Ulm/DE),
Alexander Storch (Rostock/DE), Andreas Hermann (Dresden/DE)
P437
Using induced pluripotent stem cells to model C9orf72-linked Frontotemporal
Dementia
54
ICFTD 2016
Elisavet Preza (London/GB), Ming Zhang, Ekaterina Rogaeva (Toronto/CA), Adrian
Isaacs, Martin Rossor, John Hardy, Selina Wray (London/GB)
P438
The “stressed” autophagy: Environmental stress triggers Tau aggregation pathology
through an m-TOR-dependent blockage of autophagic clearance
Ioannis Sotiropoulos, Joana Silva, Maria Bélem Marques (Braga,
Braga/Guimarães/PT), Akihiko Takashima (Obu/JP), Paula Ludovico, Nuno Sousa
(Braga, Braga/Guimarães/PT)
P439
Impaired TDP-43 Repression of Nonconserved Cryptic Exons in Alzheimer’s Disease
Liam Chen (Baltimore/US)
P440
Modelling dipeptide pathology in C9orf72-linked frontotemporal dementia
Sarah Ryan, Janis Bennion Callister, Joan Sim, Sara Rollinson, Stuart PickeringBrown (Manchester/GB)
P441
Developmental regulation of tau splicing and phosphorylation is conserved in iPSCneurons and disrupted by the 10+16 intronic mutation in MAPT
Teresa Sposito, Elisavet Preza, Argyro Alatza, Colin Mahoney (London/GB), Trevor
Bushell, Michele Zagnoni (Glasgow/GB), Tilo Kunath (Edinburgh/GB), Nick Fox,
Martin Rossor, John Hardy, Selina Wray (London/GB)
P442
CAGE expression profiling of the human iPS-derived neurons carrying mutations in
the C9orf72.
Ashutosh Dhingra, Elwira Pyz, Javier Simon-Sanchez, Melissa Castillo-Lizardo,
Yvonne Theurer, Ludger Schöls (Tuebingen/DE), Dagmar Timmann-Braun
(Essen/DE), Johannes Prudlo (Rostock/DE), Matthis Synofzik, Patrizia Rizzu, Peter
Heutink (Tuebingen/DE)
P443
TDP-43 aggregation reflects its loss of function at the proteome level
Sonja Prpar Mihevc (Ljubljana/SI), Emanuele Buratti, Marco Baralle, Francisco
Ernesto Baralle (Trieste/IT), Boris Rogelj (Ljubljana/SI)
P444
C9orf72 loss of function in mice produces FTD like behavioral deficits
Maria Belen Lopez Herdoiza, Baptiste Wilmet, Stéphanie Godart, Delphine Roussel,
Caroline Le Duigou, Magali Frah, Jonas Beal, Delphine Bouteiller, Sebastien
Dussaud, Gaelle Bruneteau, Isabelle La Ber, Sophie Nicole, Alexis Brice, Morwena
Latouche (Paris/FR)
P445
Intranuclear (GGGGCC)n RNA foci induce formation of paraspeckle-like structures
Simona Darovic, Maja Štalekar (Ljubljana/SI), Youn-Bok Lee (London/GB), Jure
Pohleven (London/SI), Miha Modic (Munich/DE), Marko Fonovič, Boris Turk
(Ljubljana/SI), Micha Drukker (Munich/DE), Christopher Shaw (Munich/GB), Boris
Rogelj (Ljubljana/SI)
P446
Early markers of tau pathology in young Tau.P301L mice: synaptic plasticity,
cognition and neuronal synchrony
Amira Latif-Hernandez, An Schreurs, Tariq Ahmed (Leuven/BE), Disha Shah
(Antwerp/BE), Fred Van Leuven (Leuven/BE), Annemie Van der Linden
(Antwerp/BE), Rudi D'Hooge, Detlef Balschun (Leuven/BE)
P447
A Biphasic Social Dominance Phenotype in Progranulin-insufficient Mice is
Associated With Abnormal Cell Signaling and Neuronal Morphology in the Amygdala
and Prefrontal Cortex
Andrew Arrant, Anthony Filiano, Brian Warmus, Alicia Hall, Erik Roberson
(Birmingham, AL/US)
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ICFTD 2016
P448
Production, detection, and characterization of proganulin (PGRN) and granulins
(GRNs).
Christopher Holler, Georgia Taylor, Tom Kukar (Atlanta/US)
11:30–13:30
Room
Postersession III - Disease modulation
Ballroom
P449
Drug screening for progranulin-deficient FTD
James Julian Doyle, Claudia Maios, Andrew Bateman, Hugh Bennett, J. Alex Parker
(Montreal/CA)
P450
Clinical evidence for disease anticipation in C9orf72 families
Sara Van Mossevelde (Antwerp, Edegem/BE), Sebastiaan Engelborghs, Ilse
Gijselinck (Antwerp/BE), Jan De Bleecker (Ghent/BE), Julie van der Zee
(Antwerp/BE), Anne Sieben (Antwerp, Ghent/BE), Kristel Sleegers (Antwerp/BE), Rik
Vandenberghe (Leuven/BE), Tim Van Langenhove, Jonathan Baets (Antwerp,
Edegem/BE), Olivier Deryck (Edegem, Bruges/BE), Patrick Santens (Ghent/BE),
Adrian Ivanoiu (Brussels/BE), Christiana Willems (Hasselt/BE), Veerle Bäumer, Van
den Broeck Marleen, Karin Peeters, Maria Mattheijssens (Antwerp/BE), De Jonghe
Peter, Patrick Cras, Jean-Jacques Martin (Antwerp, Edegem/BE), Marc Cruts, Peter
P. De Deyn, Christine Van Broeckhoven (Antwerp/BE)
P451
Intracerebroventricular infusion of streptozotocin alters brain neurochemistry:
Embelin attenuates streptozotocin-induced neurochemical alterations and cognitive
impairment in rats
Rahul Deshmukh, Rimpi Arora (Moga/IN)
P452
The role of FTD/ALS assciated protein, TDP-43, in neurite and synapse health and
function
Rachel Atkinson, Jacqueline Leung, Carmen Fernandez-Martos (Hobart/AU), Julie
Atkin (Sydney/AU), James Vickers, Anna King (Hobart/AU)
P453
The Belgian GRN founder family anno 2016: a textbook example of phenotype
heterogeneity
Eline Wauters, Sara Van Mossevelde, Kristel Sleegers, Ilse Gijselinck, Stéphanie
Philtjens, Anne Sieben (Antwerp/BE), Tim Van Langenhove (Antwerp, Edegem/BE),
Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke (Leuven/BE), Maria
Mattheijssens, Karin Peeters, Ivy Cuijt, Jean-Jacques Martin (Antwerp/BE), Patrick
Cras (Antwerp, Edegem/BE), Patrick Santens (Ghent/BE), Rik Vandenberghe
(Leuven/BE), Peter P. De Deyn (Antwerp, Groningen, The Netherlands/BE), Julie van
der Zee, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)
P454
Loss-of progranulin leads to a cell-autonomous lysosomal phenotype
Georg Werner, Katrin Fellerer, Christina M. Lang, Christian Haass, Anja Capell
(Munich/DE)
P455
Nature and nurture in modulating brain damage in pre-symptomatic monogenic FTD:
results from the GENFI study.
Enrico Premi (Brescia/JM), Jonathan Rohrer (London, UK/GB), Mario Grassi (Pavia,
Italy/IT), John van Swieten (Rotterdam, Netherlands/NL), Daniela Galimberti (Milan,
Italy/IT), Caroline Graff (Huddinge, Sweden/SE), Mario Masellis (Toronto,
Canada/CA), Fabrizio Tagliavini (Milan, Italy/IT), James Rowe (Cambridge, UK/GB),
Robert Laforce (Laval, QC, Canada/CA), Elizabeth Finger (London, ON,
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ICFTD 2016
Canada/CA), Giovanni Frisoni (Brescia, Italy/IT), Alexandre de Mendoça (Lisbon,
Portugal/PT), Sandro Sorbi (Florence, Italy/IT), Stefano Gazzina, Maura Cosseddu
(Brescia/IT), Silvana Archetti, Roberto Gasparotti (Brescia, Italy/IT), Marta Manes,
Alessandro Padovani, Barbara Borroni (Brescia/IT)
P456
New onset Autoimmune disease presenting in symptomatic Fronotemporal dementia
patients
Zachary Miller, Natanya Russek, Robin Ketelle, Anna Karydas, Lea Grinberg, Maria
Luisa Gorno-Tempini, Bill Seeley, Bruce Miller (San Francisco/US)
P457
Lifecourse factors and cognitive reserve in FTD: education, bilingualism, and place of
dwelling play a role
Suvarna Alladi (Bengaluru/IN), Thomas H Bak (Edinburgh/GB), Shailaja Mekala,
Divyaraj Gollahalli, Bapiraju Surampudi, Vasanta Duggirala, Jaydip Ray Chaudhuri,
Subhash Kaul (Hyderabad/IN)
P458
TDP-43 and FUS are exported from the nucleus independent of Exportin-1/CRM1
Helena Ederle, Dorothee Dormann (Planegg-Martinsried/DE)
P459
Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau
pathology in wild-type and MAPT transgenic mice
Robert Rottscholl, Marlen Lunow, Britta Jainsch (Marburg/DE), Gesine Respondek,
Matthias Höllerhage, Thomas W. Rösler, Hong Xu (Marburg, Munich/DE), Emilie
Bony, Jessica Le Ven (Châtenay-Malabry/FR), Vincent Guérineau (Gif-surYvette/FR), Isabelle Schmitz-Afonso (Gif-sur-Yvette, Mont-Saint-Aignan Cedex/FR),
Pierre Champy (Châtenay-Malabry/FR), Wolfgang H. Oertel (Marburg/DE), Elizabeth
S. Yamada (Marburg, Belém/BR), Günter U. Höglinger (Marburg, Munich/DE)
11:30–13:30
Room
Treatment (pharmacological/ non-pharmacological)
Ballroom
P460
TREM2-deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Xianyuan Xiang, Georg Werner (Munich/DE), Bernd Bohrmann (Basel/CH), Fargol
Mazaheri, Anja Capell, Regina Feederle (Munich/DE), Irene Knuesel (Basel/DE),
Gernot Kleinberger, Christian Haass (Munich/DE)
P461
Low-dose Lithium treatment for agitation in Frontotemporal dementia: A case series
D.P. Devanand, Gregory Pelton, Kristina D'Antonio, Jesse Strickler, William Kreisl,
James Noble, Karen Marder, Anne Skomorowsky, Edward Huey (New York, NY/US)
P462
Communication Bridge: An internet-based person centered intervention for improving
access to care and quality of life for individuals with dementia
Emily Rogalski, Marie Saxon, Marya Corden, M.-Marsel Mesulam, Kathryn Borio,
Becky Khayum (Chicago/US)
P463
Improving speech production in progressive non-fluent aphasia: a study protocol
Carlo Wilke, Marc Himmelbach, Matthis Synofzik (Tuebingen/DE)
P464
INTERACTIVE SYSTEM DESIGN TO MAINTAIN FUNCTIONALITY IN FTLD
PATIENTS.
Angela Martínez (Bogotá, Lyon/CO), Daniela Patino-Hernandez, Elkin GarcíaCifuentes, Silvia Suarez, Andrea Patiño, Carlos A. Cano-Gutiérrez, Omar Ramírez
Perez, Diego A. Chavarro-Carvajal (Bogotá/CO)
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ICFTD 2016
P465
Neuroprotective effects of Cerebrolysin in triple repeat (3R) tau transgenic model of
Pick’s disease and fronto-temporal tauopathies
Edward Rockenstein, Kirenjeet Ubhi, Michael Mante, Jazmin Florio, Anthony Adame
(La Jolla/US), Stefan Winter, Dieter Meier (Unterach/AT), Eliezer Masliah (La
Jolla/US), Hemma Brandstaetter (Unterach/AT)
P466
Disease Modifing Treatment for a bvFTD case.
Mikel Tainta, Myriam Barandiarán, Alazne Gabilondo, Fermin Moreno, Begoña
Indakoetxea, Adolfo López de Munain (San Sebastian/ES)
P468
Non-invasive salience network modulation in behavioral variant frontotemporal
dementia: preliminary results from a case series
Lorenzo Pini (Brescia/IT), Ilaria Boscolo Galazzo (Verona, London/IT), Chiara
Cobelli, Clarissa Ferrari, Maria Cotelli (Brescia/IT), Giovanni Battista Frisoni (Brescia,
Geneva/IT), Rosa Manenti (Brescia/IT), Francesca Benedetta Pizzini (Verona/IT),
Michela Pievani (Brescia/IT)
P469
Identification of best-practice-strategies in caring for people with behavioral variant
frontotemporal dementia (bvFTD): Exploration of clinical expertise - Study protocol
Claudia Dinand (Witten/DE), Martin Berwig (Witten, Leipzig/DE), Margareta Halek
(Witten/DE)
P470
Efficacy of a group visual art therapy with frontotemporal dementia patients: a pilot
study
Silvia Fostinelli, Guido Uggeri, Michela Facchinetti, Luisa Benussi, Roberta Ghidoni,
Giuseppina Di Giovanni, Giuseppe Rossi, Elena Bertocchi, Rosaria Pioli, Giuliano
Binetti (Brescia/IT)
P471
Application of MarteMeo® Counselling to people with behavior variant frontotemporal
dementia and their caregivers (AMEO-FTD) – Study protocol for a feasibility study
Martin Berwig (Witten, Leipzig/DE), Claudia Dinand, Margareta Halek (Witten/DE)
P472
Effect of repetitive transcranial magnetic stimulation on cognitive, behavioral and
emotional functioning in behavioral variant of frontotemporal dementia
Katarzyna Kowalska, Jakub Antczak, Marta Banach, Aleksandra Klimkowicz Mrowiec (Kraków/PL)
P473
Advanced frontotemporal dementia - an indication for palliative care?
Lina Riedl, Janine Diehl-Schmid (Munich/DE)
P474
Improvement of speed processing and neuropsychiatric symptoms in FrontoTemporal Dementia after transcranial Direct Current Stimulation
Simona Gardini (Parma/IT), Roberta Ferrucci, Fabiana Ruggiero, Maurizio Vergari,
Francesca Mameli (Milan/IT), Marco Spallazzi, Federica Barocco, Anna Miucci
(Parma/IT), Andrea Arighi (Milan/IT), Paolo Caffarra (Parma, Parma, italy/IT), Elio
Scarpini, Alberto Priori (Milan/IT)
P475
Targeting tau protein in therapy of human tauopathies: Can we use the same vaccine
for treatment of various tau neurodegenerative diseases?
Norbert Zilka, Branislav Kovacech, Eva Kontsekova, Michal Novak (Bratislava/SK)
P476
Frontotemporal dementia (FTD): A review and a general approach to nonpharmacological treatment – the Hong Kong experience
Connie Tin Yee YAN, Joshua TSOH, Daphne ST LAW (Hong Kong/HK)
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ICFTD 2016
P477
Study design of a phase 2 randomized controlled trial of intranasal oxytocin for
symptomatic treatment in FTD
Elizabeth Finger (London/CA), Harold Feldman (San Diego, Vancouver/US), Jeffrey
Cummings (Las Vegas/US), Adam Boxer (San Francisco/US)
P478
Clinical drug trials in behavioral variant frontotemporal dementia: problems and
challenges
Janine Diehl-Schmid (Munich/DE)
13:30–14:50
Room
Chairs
Session 10: Disease modulation
Lecture Hall
Christian Haass (Munich/DE), Don Cleveland (San Diego, CA/US)
13:30
Gene silencing therapy for human neurodegenerative disease
Don Cleveland (San Diego, CA/US)
13:55
Therapeutic reduction of ataxin 2 improves motor performance and extends lifespan
in a mouse model of TDP-43 proteinopathy
Aaron Gitler (Stanford, CA/US)
14:20
hnRNP proteins as general enhancers or suppressors of TDP-43 gain- and loss-offunction pathological properties
Emanuele Buratti, Chiara Appocher, Sara Cappelli, Cristiana Stuani, Maurizio
Romano, Fatemeh Mohagheghi, Fabian Feiguin (Trieste/IT)
O18
14:35
O19
Reducing levels of Tmem106b as a therapeutic strategy in an FTLD-TDP mouse
model
Alexandra Nicholson, Ralph Perkerson, Jeannie Chew, Aishe Kurti, Tammee
Parsons, Emilie Perkerson, Karen Jansen-West, Monica Castanedes-Casey, Linda
Rousseau, Jeannette Stankowski, Dennis Dickson, John Fryer, Leonard Petrucelli,
Rosa Rademakers (Jacksonville/US)
15:10–16:40
Room
Chairs
Session 11: Treatment
Lecture Hall
Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)
15:20
A phase 3 trial of the tau and TDP-43 aggregation inhibitor, leuco-methylthioniniumbis(hydromethanesulfonate) (LMTM), for behavioural variant frontotemporal dementia
(bvFTD)
Howard Feldman (La Jolla/US), Serge Gauthier (Quebec/CA), Lon Schneider (Los
Angeles/US), Gordon Wilcock (Oxford/GB), Giovanni Frisoni (Geneva/CH), Peter
Bentham (Birmingham/GB), Jiri Hardlund (Aberdeen/GB), Karin Kook (Bethesda/US),
Damon Wischik, Bjoern Schelter, John Storey, Charles Harrington, Claude Wischik
(Aberdeen/GB)
O20
15:35
O21
An 8-week, Open-label, Dose-Finding Study of Nimodipine for the Treatment of
Progranulin Insufficiency from GRN Gene Mutations
Sharon Sha (Palo Alto/US), Zachary Miller, Sang-Won Min, Yungui Zhou, Laura Mitic,
Anna Karydas, Mary Koestler, Richard Tsai, Chiara Corbetta-Rastelli, Sophie Lin,
Emma Hare, Jesse Brown, Ryan Fitch, Ryan Powers, Lauren Herl Martens (San
Francisco/US), Mehrdad Shamloo (Palo Alto/US), Anne Fagan (St. Louis/US), Robert
Farese, Jr., William Seeley, Rodney Pearlman, Bruce Miller, Li Gan, Adam Boxer
(San Francisco/US)
59
ICFTD 2016
15:50
O22
Clinical trial of COMT-inhibition in 28 patients with FTD
Edward Huey (New York, NY/US), Venkata Mattay (Baltimore, MD/US), Christopher
Habeck, Masood Manoocheheri (New York, NY/US), Nicole Armstrong (Baltimore,
MD/US), D.P. Devanand (New York, NY/US), Daniel Weinberger (Baltimore, MD/US),
Jordan Grafman (Chicago, IL/US)
16:05
Panel discussion: Update and future directions on clinical trials in FTD and
associated disorders
Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)
16:40–17:00
Room
Chairs
Closing Remarks
Lecture Hall
Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)
60

Scientific Program - 10th International Conference on

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