Canadian Medications. Viagra Vom Zoll Abgefangen

Canadian Medications. Viagra Vom Zoll Abgefangen

ATP & HISTIDINE INTERRELATIONSHIPS
A CLUE TO PRE-HISTORIC "BIO"- CHEMISTRY ?
H2C
HN C
P-Ribosylformylglycinamide
NHCOCH2NH2
NH 2
N
C
C
N
CH
C
HC
N R -P
N
OH OH
P-Ribosylglycinamide
CH2OP
O
GLYCINE
ADP
P-Ribosylamine
C
N
OP-O-P
HC
OH OH
N
C
C
H2N
C
N
N
C
N
H2N
C N
C
CH
N
RP
P-Ribosyl5-amino-4-imidazole
N-succinylcarboxamide
C
C
NH
C
H
H
P OCH 2 C
C
N
C
C
N
RP
H
C
C
C
C
NH 2
OC
C
NH
HC
OH OH
+
C CH2CH(NH3)CH2OH
NH
C
H
CH
N
Glutamine
H
NH
CH
N
C
RP
+
OCCH2CH2CH (NH3 ) COO-
H
Histidinal
N
C
NH
HC
H 2N
CH
H
+
CH2CH(NH3)CHO
CH 2
O
N
R-P
P OCH 2
CONH 2
C
OH OH
N
OH
Histidinol
Fumarate
CH
CH
R-P-O-P-O-P
N
N
C
P-Ribosyl-5-aminoimidazole-4-carboxamide
N
OH
HC
N
-OOC.CH.CH2 COOHNCO
RP
N
RP
Fumarate
CH
C
HCO
NH
N
C
C
P-Ribosyl-AMP
N
Inosine-P (IMP)
H2 N
OH
C
O
C
CH
N
Succinate
RP
NH
HC
HC
N
H2N
CH 2 O P
O
HISTIDINE
C
N
P-Ribosyl- 5-formamidoimidazole-4-carboxamide
P-Ribosyl-ATP
NH
CH
N
H
CH
N
CH 2 O P
O
+
CH2CH(NH3)COO-
HC
C
C
P-Ribosyl5-amino-4-imidazole
carboxylate
Aspartate
N
C
R-P-O-P-O-P
OH
N
O
C
RP
H2N
Adenylosuccinate
HN
CH
N
-OOC
CH
HC
HC
Fumarate
N
P-Ribosyl- 5-amino-4-imidazole
N
C
ATP
PRPP
HC
H 2N C
-OOC.CH.CH 2 COONH
N
C
C
N
CH
HC
C
N
RP
N
NH 2
N
C
C
N
CH
C
HC
N R -P-O-P
N
NH2
CH2OP
O
P-Ribosyl-P-O-P
RP
ADENOSINE-P
(AMP)
NH2
OH OH
NH
P-Ribosylformylglycinamidine
NH
H2C
CHO
OC
NH
RP
CH2OP
O
NH
CHO
N
C
N
N
N
NH
CH
+
CH2CH(NH3)CH2OP
CH
C
N
C CH2COCH2O P
HC
N
C
H H
POCH2 C C
C
OH OH HN
Imidazole glycerol- P
RP
P-Ribosylformimino5-aminoimidazolecarboxamide
HC
*
P-Ribulosyl-5-formimino5-aminoimidazolecarboxamide
CH
C
H
NH
P Formatio
AT
n
Imidazoleacetol- P
Histidinol-P
PRPP
ATP
HISTIDINE
S
on
HI
TI
DIN
E F or m
at
i
Histidine and purines have a unique and fascinating interrelationship. They both originate
from the same compound - PRPP. Both are characterised by the heterocyclic imidazole group.
ATP is involved in the synthesis of histidine, not as a source of energy but as a supplier of one
each of its carbon and nitrogen atoms. One of the intermediary reactions ( ) involves the
splitting of the molecule into TWO imidazole fragments, one of which becomes the basis of the
histidine molecule while the other leads to the re-formation of the ATP - an ATP Cycle ! Since
this ATP feeds into a cycle, de novo ATP must be derived fron PRPP in the usual way shown
in the top (Purple) pathway.
*
The imidazole component of the histidine molecule is often a major influence in the active site
of an enzyme. Could the imidazole component of purines have a similar activity? Some
RNAs (Ribozymes) are known to be catalytic. Is this a clue to a pre-historic "RNA World"
responsible for catalysis before the evolution of the "Protein World" ?
Designed by Donald Nicholson
c 2002 IUBMB