Tuesday 3rd December 2013 Conference Program

Conference Program
Tuesday 3rd December 2013
Registration
1:00pm - 6:30pm
The conference registration desk will be manned from 8.00am each day of the meeting.
Afternoon Tea
3:00pm - 3:50pm
Whitesands Lobby
Whitesands Lobby
Conference Welcome
3:50pm - 4:00pm
Chairs: Sue Clark & Catherine Suter
Whitesands Conference Room
Keynote Lecture
4:00pm - 5:00pm
Chair: Sue Clark & Catherine Suter
Whitesands Conference Room
4:00pm Henk Stunnenberg
Epigenomics functionally indexing chromatin in health and disease
Session 1: The Epigenome
5:00pm - 6:30pm
Chair: Sue Clark
abs# 1
Whitesands Conference Room
NB: These presentations will be followed by 16 two minute fast forward presentations from abstracts also presenting as posters. Please
refer to poster numbers of these abstracts to find the details in the proceedings.
5:00 PM Ryan Lister
Global epigenomic reconfiguration during mammalian brain development
abs# 2
5:30 PM Mark A Rubin
The Estrogen receptor alpha regulated NEAT1 long non-coding RNA promotes prostate cancer progression
abs# 3
17:50PM Fast Forward Presentations
Welcome BBQ
6:30pm - 8:00pm
Mermaids Bar and Grill
This is an included function for all delegates.
Poster Session 1
8:00pm - 9:30pm
Whitesands Lobby & Sandy Foot Bar
Session sponsored by Agilent
Kirsten Grønbæk
Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma
with very poor outcome?
abs# 100
Stephanie Biergans
DNA methyltransferases in honeybees: Their role and target genes during long-term memory formation
abs# 101
Rhys Allan
A role for a histone methyltransferase in preserving immune homeostasis through a chromatin-independent mechanism
abs# 102
Emma Beckett
Circulating miRNAs (155, 15a and 182) correlate with blood folate in an MTHFR genotype dependent manner abs# 103
Bernadette Jones
The involvement of histone acetylation enzymes in a mouse model of chronic obstructive pulmonary disease abs# 104
Michelle Ong
Conference Program
The epigenetic regulator UHRF1 binds to both the N- and C-terminal domains of the deubiquitylase, USP7 abs# 105
Brendon Monahan
Repression of gene expression by the fission yeast SWI/SNF complex independent of its chromatin remodeling activity.
abs# 106
Tony Vuocolo
Epigenetic and transcriptional differences between brown and white adipose tissues.
abs# 107
Anjum Zafar
“Chromatin tethered Protein Kinase C family members and their dual- signalling and nuclear role in regulating transcription
of inducible genes in cancer stem cells”
abs# 108
Jasmine Li
Chromatinised PKC-θ marks enhancer domains in human memory CD4+ T cells
abs# 109
Joshua Denham
Leukocyte DNA methylation changes after 4 weeks of high-intensity exercise training
abs# 110
Peter Hickey
Simulating whole genome bisulfite sequencing data
abs# 111
Emily Remnant
Differential methylation in the honey bee germline
abs# 112
Jeannette Lechner-Scott
Methylation changes at the HLA-DRB1 locus in CD4+ T-Cells are associated with multiple sclerosis
abs# 113
Yukihiko Kato
Histone deacetylase inhibitor MS-275 restored retinoid sensitivity and had an antitumor effect in combination with retinoic
acid Am80 in human cutaneous T cell lymphoma abs# 114
Cheryl Li
Genome-wide mapping of 5-hydroxymethylcytosine in glioblastomas
abs# 115
Chamindie Punyadeera
Head and Neck Cancer Detection is Spitting Distance Away.
abs# 116
Sarah Cohen-Woods
Scars of stress: does exposure to stressful experience alter methylation of our DNA?
abs# 117
Christiane Theda
Differential methylation of whole blood genomic DNA of preterm versus term infants at birth and 18 years of age
abs# 118
Clare Stirzaker
Methyl-CpG-Binding Domain Protein MBD2 plays a critical role in initiating the spread of DNA hypermethylation and
chromatin remodeling in prostate cancer
abs# 119
Adam Cook
A balancing act between the chaperone NASP and lysosomal degradation to fine-tune histone supply and maintain genome
integrity
abs# 120
Ruth Pidsley
Epigenetic profiling of the prostate cancer microenvironment
abs# 121
David Humphreys
miRNA profiling in hearts with LVAD support
abs# 122
Andrew Stone
BCL-2 hypermethylation is a potential biomarker of sensitivity to anti-mitotic chemotherapy in endocrine-resistant breast
cancer.
abs# 123
Hugh French
The Role of RNA-directed Epigenetic Remodelling in Cancer
Eva Baxter
Cyclical DNA methylation in estrogen receptor-regulated transcription
Hannah Nicholas
SUMV-1 and SUMV-2 regulate vulval development in Caenorhabditis elegans
Christine Chiu
Quantification of global DNA methylation in the kidneys of spontaneously hypertensive mice
Warwick Locke
abs# 124
abs# 125
abs# 126
abs# 127
Conference Program
Epigenomic analysis of early breast carcinogenesis identifies differentially methylated loci as candidate biomarkers
abs# 128
Kristen Yeung
Global DNA methylation status in the offspring of experimental preeclamptic and normotensive baboon pregnancies
abs# 129
Jiang Hu
Investigating epigenetic mechanisms that control protocadherin expression in neurons
abs# 130
Richard D'Andrea
GADD45A expression in AML alters the DNA methylation and expression of key tumor suppressor genes
abs# 131
Jason Ross
“Stop_gap, measure”. Tools for handling deep bisulphite sequencing data.
abs# 132
Hilal Varinli
Reduced Methylome Sequencing using GW-COBRA and LA-COBRA
abs# 133
Michelle Holland
Environmental perturbation of the mammalian germ-line and developmental outcomes in the next generation abs# 134
Conference Program
Wednesday 4th December 2013
Session 2: Functional Epigenomics
8:30am - 10:30am
Chair: Phillippa Taberlay
Whitesands Conference Room
8:30 AM Ricky Johnstone
Novel cancer therapies that target the epigenome
abs# 4
9:00 AM Joel Mackay
Probing the structure and function of a 1-MDa chromatin remodeling complex
abs# 5
9:20 AM Sarah Harten
An ENU mutagenesis screen identifies the first mouse mutants of a novel epigenetic modifier, Rearranged L-Myc
Fusion (Rlf).
abs# 6
9:40 AM Andrew Keniry
Identifying novel epigenetic modifiers of pluripotency and reprogramming using X inactivation as a model system
abs# 7
10:00 AM Melissa Fullwood
3-D insights into chromatin and transcription in human cancer cells
abs# 8
Morning Tea
10:30am - 11:00am
Session 3: Epigenetics and Disease 1
11:00am - 1:00pm
Chair: Peter Molloy
Whitesands Lobby
Whitesands Conference Room
11:00 AM Assam (Sam) El-Osta
TBA
11:30 AM Jason Lee
EZH2-mediated regulation of protein stability in breast cancer
abs# 9
abs# 10
11:50 AM Florent Chang Pi-Hin
Extraction, amplification and methylation analysis of DNA from blood: where and how to improve the workflow
abs# 11
12:05 PM Phillippa Taberlay
Massive Reorganization of Nucleosome Distribution and DNA Methylation at Distal Regulatory Elements in
Cancer.
abs# 12
12:25 PM Jane Visvader
The mammary stem cell hierarchy and its molecular regulators
abs# 13
Lunch Break
1:00pm - 2:00pm
Whitesands Lobby
Afternoon Break
2:00pm - 4:00pm
Delegates are welcome to enjoy the surrounds of Shoal Bay. Afternoon Tea will be served when sessions start at 4.00pm
Session 4 - Development and Inheritance
4:00pm - 6:00pm
Chair: Peter Waterhouse
Whitesands Conference Room
NB: These presentations will be followed by 12 two minute fast forward presentations from abstracts also presenting as posters. Please
refer to poster numbers of these abstracts to find the details in the proceedings.
4:00 PM Ueli Grossniklaus
TBA
4:30 PM Ian Dodd
Collaboration between CpG sites is needed for stable inheritance of DNA methylation states
abs# 14
abs# 15
Conference Program
Conference Program
4:50 PM Jennifer Cropley
Environmentally induced epigenetic variation and inheritance: programming the risk of disease abs# 16
5:10 PM Daniele Belluoccio
Comprehensive Human and Mouse DNA Methylation Profiling with SureSelect Target Enrichment System
abs# 17
Dinner Break
6:00pm - 8:00pm
Delegates are welcome to book dinner at Shoal Bay Resort and Spa or another restaurant in town
Poster Session 2
8:00pm - 10:00pm
Session sponsored by
Whitesands Lobby
Boris Novakovic
Postnatal Stability, Tissue and Timing Specific Effects, of AHRR Methylation Change in Response to Maternal Smoking
throughout Pregnancy.
abs# 200
Boris Novakovic
Alternative Lengthening of Telomeres (ALT) in Human Placenta: First Evidence for ALT in Non-Cancerous Human Tissue
abs# 201
Leah Morenos
Epigenetic Modifications Regulate DLEU2 and Tumour Suppressor miR15a/16-1 in Paediatric Acute Myeloid Leukaemia
abs# 202
Maxim Nekrasov
Different strategies of chromatin remodelling at the promoters
abs# 203
Norah Algahtani
Role of IL-6 in inducing epigenetics modifications in breast stromal fibroblasts
abs# 204
Pamela Mukhopadhyay
What determines whether an X-linked gene is dependent upon Smchd1 for X inactivation?
abs# 205
Junxin Liang
Role of NPMT in cell growth and DNA damage repair
abs# 206
Sharon Hollins
miRNA regulation of gene expression in the adult entorhinal cortex following maternal infection and adolescent
cannabinoid exposure
abs# 207
Nur Anuar
Targeting a multi-copy histone variant gene for knockout using TALEN technology in mice.
abs# 208
Lloyd Graham
CRNDE – A long non-coding RNA involved in development, energy metabolism and cancer
abs# 209
Daniele Belluoccio
Comprehensive Human and Mouse DNA Methylation Profiling with SureSelect Target Enrichment System abs# 210
Renae Domaschenz
Comparative Epigenetic Landscapes and Regulation of the Epigenome Across Divergent Taxa
abs# 211
Ricardo De Paoli-Iseppi
Characterisation of Multiple Endocrine Neoplasia Type 1 (MEN1) promoter methylation in disease severity abs# 212
Edwina Wing-Lun
Maternal obesity alters cardiac microRNA expression in offspring independent of genotype
abs# 213
Sarah Ashley
Maternal folate status as a modifier of epigenetic profile in human neonatal CD4+ T cells
abs# 214
Belinda Goldie
Detection and analysis of miRNA in the nucleus of human neuronal cells
abs# 215
Jessica Stringer
Polycomb Repressive Complex 2 in germ-line development and epigenetic inheritance.
abs# 216
Susan van Dijk
DNA methylation profiling in a child cohort
abs# 217
Natasha Jansz
Identifying Functional Interactions Between Smchd1 and Other Epigenetic Modifiers.
abs# 218
Ying Hu
Conference Program
The wnt antagonist gene sfrp5 is down-regulated in azoxymethane-induced rat colon tumors
abs# 219
Navind Jayasooriah
Sertoli cell microvesicles as a vector for epigenetic inheritance
abs# 220
Shreya Bhattacharya
Identifying miRNA signatures that define Osteosarcoma
abs# 221
Raul Chavez Valencia
In vitro exposure of human blood mononuclear cells to active vitamin D does not induce substantial change to DNA
methylation on a genome-scale
abs# 222
Joshua Atkins
The influence of copy number variation on microRNA and target genes in a cohort of patients with schizophrenia abs# 223
Sarah Kinkel
Function of PRC2 accessory factors in haematopoietic stem cells.
abs# 224
Darcy Moore
Identification of epigenetic modifiers involved in neural stem cell function
abs# 225
Ksenia Skvortsova
The Role of 5-hydroxymethylcytosine and DNA Demethylation in Cancer abs
# 226
Emma Cazaly
Epigenomic and genomic analysis of familial prostate cancer.
abs# 227
Amanda Khoury
Does the boundary element CTCF play a role in epigenetic deregulation of domains in cancer?
abs# 228
Qian Du
Role of the Epigenetic Modifier MBD2 in DNA Methylation in Cancer
abs# 229
Lauren Bourke
The first mouse mutants of a novel epigenetic modifier Rearranged L-Myc Fusion (Rlf) display defects in heart development
abs# 230
Justin Bloomfield
Epigenetic Profiling During Brassica Reproductive Development
abs# 231
Kelan Chen
Structural and Functional Characterization of Epigenetic Regulator Smchd1
abs# 232
Raphael Ricon
Alteration of DNA methylation pattern of QQS along Arabidopsis development
abs#233
Conference Program
Thursday 5th December 2013
Session 5: Epigenetics and Disease 2
8:30am - 10:30am
Chair: Hamish Scott
Whitesands Conference Room
8:30 AM Peter Jones
Reactivating Epigenetically Silenced Genes
abs# 18
9:00 AM Clare Stirzaker
Epigenetic prognostic biomarker panel has potential to stratify triple negative breast cancers
abs# 19
9:20 AM Maxim Ivanov
Hydroxymethylcytosine (5hmC) in human liver: quantification, genome-wide mapping and profiling with singlebase resolution in ADME genes
abs# 20
9:40 AM Stephen Bradford
Epigenome profiling of primary human subcutaneous and visceral adipocytes reveals differences in potential
regulation of developmental and metabolism genes.
abs# 21
10:00 AM Jingde Zhu
Not available at time of printing
abs# 22
Morning Tea
10:30am - 11:00am
Session 6 – Chromatin
11:00am - 1:00pm
Chair: Adele Holloway
Whitesands Lobby
Whitesands Conference Room
11:00 AM David Tremethick
Histone variant selectivity at the transcription start site: H2A.Z or H2A.Lap1
abs# 23
11:30 AM Philippe Collas
Closing the nuclear lamina down on gene promoters
abs# 24
11:50 AM Fatima Valdes Mora
Defining the role of aberrant H2A.Z acetylation of promoter and enhancer regions in cancer-associated gene
activation
abs# 25
12:10 PM Anjum Zafar
Chromatin tethered Protein Kinase C family members and their dual- signalling and nuclear role in regulating
transcription of inducible genes in cancer stem cells
abs# 26
12:30 PM Peggy Farnham
Using GWAS, Epigenomics, and Genome Engineering to Characterize Cancer-Associated Enhancers abs# 27
Lunch Break
1:00pm - 2:00pm
Whitesands Lobby
Afternoon Break
2:00pm - 4:00pm
Session 7- Epigenetics Across Species
4:00pm - 6:00pm
Chair: Jennifer Cropley
Whitesands Conference Room
4:00 PM Frank Grutzner
Evolution of replication timing, interchromosomal interaction and monoallelic expression in mammals abs# 28
4:30PM Ben Oldroyd
TBA
abs# 29
5:00 PM Ozren Bogdanovic
Reading the epigenome: developmental and evolutionary dynamics of 5-(hydroxy) methylcytosine readers in
vertebrates
abs# 30
Conference Program
5:20PM Michelle Garred
BiSulfite Amplicon Sequencing and Targeted Expression Profiling on the Illumina MiSeq
5:35 PM David Martin
Genome methylation in D. melanogaster: it’s there after all
abs# 31
abs# 32
Dinner & Free Evening
6:30pm - 11:59pm
This evening is free for delegates to do as they please.
Morning Tea
10:30am - 11:00am
Whitesands Lobby
Session 9 - Epigenetics and RNA
11:00am - 12:40pm
Chair: Ryan Lister
Whitesands Conference Room
11:00 AM Peter Waterhouse
TBA
abs# 38
11:30 AM Charles Nicolet
Evaluation of Commercially Available RNA Amplification Kits on Small Input Samples for RNA-Seq abs# 39
11:45 AM Rob Richards
RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases
abs# 40
12:05 PM Shu Ly Lim
HEN1 is involved in the stabilization of pachytene piRNAs, retrotransposon silencing and translational regulation
during spermatogenesis.
abs# 41
12:25 PM Kevin Morris
Genomic dark matter: the complexity of long Non-Coding RNAs from mechanism to therapeutic abs# 42
Lunch Break
12:55pm - 2:10pm
Whitesands Lobby
Session 10 - Developmental Epigenetics
2:10pm - 3:30pm
Chair: Richard Saffery
Whitesands Conference Room
2:00 PM Jeffrey Craig
Epigenetic studies of a newborn twin cohort: insights into pre- and postnatal development
abs# 43
2:30 PM Julian Peat
Dissecting epigenetic reprogramming in the zygote: active demethylation by TET3 and the 6th base. abs# 44
2:50 PM Timothy Spector
Large Scale Integrated Epigenomic Twin studies for Common complex traits
abs# 45
Afternoon Tea
3:30pm - 4:00pm
Whitesands Lobby
Keynote Lecture
4:00pm - 5:00pm
Chair: Catherine Suter
Whitesands Conference Room
4:00 PM Vincent Colot
Transgenerational Epigenetic Inheritance In Arabidopsis
Awards and Conference Close
5:00pm - 5:30pm
Conference Dinner Cruise
6:30pm - 11:00pm
Moonshadow Cruise Vessel
abs# 46
Whitesands Conference Room
Conference Program
Dinner Bus Transfers will collect delegates attending dinner from the front of the Conference Venue at 6.30pm Sharp. Don't
be late.
Saturday 7th December
9.00AM Bus departs Shoal Bay Resort and Spa back to Newcastle Airport, Sydney (Garvan)
and Sydney Airport (Domestic Terminal). Please be on time as the bus will not wait.