Curriculum Vitae

Curriculum Vitae
Uğur ÖZBEK, M.D., Ph.D.
[email protected]
Present Position:
Director
Professor, Member-Genetics Department,
Institute of Experimental Medicine (DETAE),
Istanbul University, Turkey
Undergraduate Education:
Graduate Education:
1979-1981
Anittepe High School, Ankara, Turkey
Preclinic,
Cerrahpasa Medical Faculty, Istanbul University
1981-1986
Clinical
Cerrahpasa Medical Faculty, Istanbul University
Helsinki University Medical Faculty, Finland
04.31.1986 Doctor of Medicine (diploma nr.: 3717, Turkey)
Postgraduate Education and Positions:
1989-1995
Ph.D. student, Basic Oncology Department,
Oncology Institute, Istanbul University
1991
Laboratory rotation (6 months)
Prenatal Diagnosis Center (PRETAM),
Istanbul University Faculty of Medicine,
1991-1992
Laboratory rotation (8 months)
Molecular Genetics Lab., Biology Dept.,
Bogazici University, Istanbul
1994
Visiting Researcher, (6 months)
G. Gaslini Institute, Oncology Research Lab., Genoa,
Italy (fellowship from Italian Government)
1994-1996
Research Assistant
Genetics Department, Institute of Experimental
Medicine, Istanbul University
1995
PhD. degree in Cancer Genetics
Oncology Institute, Istanbul University
1996
Visiting Researcher, Tettamanti Leukemia Research
Lab., University of Milan, Italy
1996-97
Assistant Professor in Genetics
Genetics Department, Institute of Experimental
Medicine, Istanbul University
2.11.1997
Associate Professor in Basic Oncology
1998-2000
Research Associate, Genetics Department,
St. Jude’s Children Research Hospital, Memphis, USA
2002- 2007
2003
2003
2006-2007
2008
2009-
Chairman
Genetics Department, Institute of Experimental
Medicine, Istanbul University
Clinical Observer, Cancer Genetics Section,
Royal Marsden Hospital, Surrey Sutton, England
Full Professor, Genetics Department, Institute of
Experimental Medicine, Istanbul University, Turkey
Querido Chair, Visiting Professor
Erasmus University Medical Center
Rotterdam-the Netherlands
Specialist in Medical Genetics, Istanbul University
Director, Institute of Experimental Medicine, Istanbul
University
Ongoing International/National Projects-Partnerships:
1. Core Partner. EPICURE. Functional Genomics and Neurobiology of Epilepsy: a basis
for new therapeutic strategies. Integrated Project. EC contract number
LSH-CT-2006-037315 (EPICURE) FP6 - Thematic priority LIFESCIHEALTH
(http://www.epicureproject.eu/)
2. National Node representative: BBMRI Consortium.
http://bbmri.eu/images/ammap/world.htm
3. Partner. MedGeNet. Euro-Mediterranean Network for Genetic Services. FP6-2004INCO-MPC-3. (031968) (http://medgenet.tredueuno.it/)
4. Partner. PHGEN. Public Health Genetics European Network. OJ2005/C11
(http://www.phgen.eu)
5. Partner. ELN-European LeukemiaNet. (LSH-2002-2.2.0-3). Strengthen and develop
scientific and technological excellence in research and therapy of leukemia
(http://www.leukemia-net.org)
6. Partner. ORPHANET-European Orphan Disease Network. DG Public Health ( EC
Contract no. 2006 119) (www.orpha.net)
7. Partner. Bilateral collaborative agreement. Istanbul University-Ludwig Institute for
Cancer Research- New York Branch James Kerr programme
(http://www.licr.org/F_sites/f4_kerr.php)
8. Project coordinator. (2010-2013). TUBITAK-SBAG-109S2128. Intensified
Cooperation (IntenC): Promotion of German-Turkish Higher Education Research.
Project name: Genome-wide integrated methylome analyses in idiopathic
generalized epilepsies
9. Project coordinator. (2010-2013). TUBITAK-SBAG-109S295. Project name: Genome
wide expression array analysis in T cell acute lymphoblastic leukemia.
PUBLICATIONS
1. Møller RS, Weber YG, Klitten LL, Trucks H, Muhle H, Kunz WS, Mefford HC, Franke A,
Kautza M, Wolf P, Dennig D, Schreiber S, Rückert IM, Wichmann HE, Ernst JP, Schurmann
C, Grabe HJ, Tommerup N, Stephani U, Lerche H, Hjalgrim H, Helbig I, Sander T; EPICURE
Consortium.Zimprich F, Mörzinger M, Feucht M, Suls A, Weckhuysen S, Claes L, Deprez L,
Smets K, Van Dyck T, Deconinck T, De Jonghe P, Velizarova R, Dimova P, Radionova M,
Tournev I, Kancheva D, Kaneva R, Jordanova A, Kolonivej D, Møller RS, Kjelgaard DB,
Hjalgrim H, Helsinki B, Lehesjoki AE, Siren A, Baulac S, Leguern E, Campus K, Helbig I,
Muhle H, von Spiczak S, Ostertag P, Stephani U, Leber M, Leu C, Sander T, Toliat MR,
Trucks H, Nürnberg P, Hempelmann A, Rüschendorf F, Sander T, Elger CE, Kleefuß-Lie
AA, Kunz W, Surges R, Gaus V, Janz D, Sander T, Schmitz B, Klein KM, Reif PS, Oertel WH,
Hamer HM, Rosenow F, Becker F, Weber Y, Lerche H, Marini C, Guerrini R, Mei D, Norci
V, Zara F, Striano P, Robbiano A, Pezzella M, Bianchi A, Gambardella A, Tinuper P, La
Neve A, Capovilla G, Vigliano P, Crichiutti G, Vanadia F, Vignoli A, Coppola A, Striano S,
Giallonardo EM, Franceschetti S, Belcastro V, Benna P, Coppola G, De Palo A, Ferlazzo E,
Vecchi M, Martinelli V, Bisulli F, Beccaria F, Del Giudice E, Mancardi M, Stranci G, Scabar
A, Gobbi G, Giordano I, Koeleman BP, de Kovel C, Lindhout D, de Haan GJ, Ozbek U,
Bebek N, Baykan B, Ozdemir O, Ugur S, Kocasoy-Orhan E, Yücesan E, Cine N, Gokyigit A,
Gurses C, Gul G, Yapici Z, Ozkara C, Caglayan H, Yalcin O, Yapici Z, Yalcin D, Turkdogan D,
Ozkara C, Dizdarer G. Exon-disrupting deletions of NRXN1 in idiopathic generalized
epilepsy. Epilepsia. 2013 Feb;54(2):256-64. doi: 10.1111/epi.12078. Epub 2013 Jan 7.
2. Zorba OU, Sirma S, Ozgon G, Salabas E, Ozbek U, Kadioglu A. Comparison of apoptotic
gene expression profiles between Peyronie's disease plaque and tunica albuginea.
Comparison of apoptotic gene expression profiles between Peyronie's disease plaque
and tunica albuginea. Adv Clin Exp Med. 2012 Sep-Oct;21(5):607-14.
3. Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink
JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling,
Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
PLoS Biol. 2012 Nov;10(11):e1001430. doi: 10.1371
4. Uz B, Tatonyan SC, Sayitoglu M, Erbilgin Y, Ng OH, Buyukasik Y, Sayinalp N, Aksu S, Goker
H, Ozcebe OI, Ozbek U, Haznedaroglu IC. Local hematopoietic renin-angiotensin system
in myeloid versus lymphoid hematological neoplastic disorders. J Renin Angiotensin
Aldosterone Syst. 2012 Nov 6. [Epub ahead of print]
5. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C,
Akpinar B, Ozbek U, Buyukdevrim S, Yazici Z. The role of mediastinal adipose tissue
11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid expression in the
development of coronary atherosclerosis in obese patients with ischemic heart disease.
Cardiovasc Diabetol. 2012 Sep 25;11(1):115.
6. Atalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici-Duman B, Gunay D, Akpinar B,
Sagbas E, Ozbek U, Buyukdevrim AS. 11β-hydroxysteroid dehydrogenase type 1 gene
expression is increased in ascending aorta tissue of metabolic syndrome patients with
coronary artery disease. Genet Mol Res. 2012 Aug 31;11(3):3122-32.
7. Consortium E, Consortium E, Steffens M, Leu C, Ruppert AK, Zara F, Striano P, Robbiano
A, Capovilla G, Tinuper P, Gambardella A, Bianchi A, La Neve A, Crichiutti G, de Kovel CG,
Kasteleijn-Nolst Trenité D, de Haan GJ, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG,
Becker F, Lerche H, Steinhoff BJ, Kleefuß-Lie AA, Kunz WS, Surges R, Elger CE, Muhle H,
von Spiczak S, Ostertag P, Helbig I, Stephani U, Møller RS, Hjalgrim H, Dibbens LM,
Bellows S, Oliver K, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C,
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Guerrini R, Lehesjoki AE, Siren A, Guipponi M, Malafosse A, Thomas P, Nabbout R,
Baulac S, Leguern E, Guerrero R, Serratosa JM, Reif PS, Rosenow F, Mörzinger M, Feucht
M, Zimprich F, Kapser C, Schankin CJ, Suls A, Smets K, De Jonghe P, Jordanova A,
Caglayan H, Yapici Z, Yalcin DA, Baykan B, Bebek N, Ozbek U, Gieger C, Wichmann HE,
Balschun T, Ellinghaus D, Franke A, Meesters C, Becker T, Wienker TF, Hempelmann A,
Schulz H, Rüschendorf F, Leber M, Pauck SM, Trucks H, Toliat MR, Nürnberg P, Avanzini
G, Koeleman BP, Sander T. Genome-wide association analysis of genetic generalized
epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol
Genet. 2012 Oct 2. [Epub ahead of print]
Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C,
Akpinar B, Ozbek U, Buyukdevrim AS, Yazıcı Z. Mediastinal adipose tissue expresses a
pathogenic profile of 11 β-hydroxysteroid dehydrogenase Type 1, glucocorticoid
receptor, and CD68 in patients with coronary artery disease. Cardiovasc Pathol. 2012
Sep 3. [Epub ahead of print]
Hannon MM, Lohan F, Erbilgin Y, Sayitoglu M, O'Hagan K, Mills K, Ozbek U, Keeshan K.
Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. Br J Haematol. 2012
Sep;158(5):626-34
Yavuz EN, Ozdemir O, Catal S, Bebek N, Ozbek U, Baykan B. Bromodomain-containing
protein 2 gene in photosensitive epilepsy. Seizure. 2012 Oct;21(8):646-8
Sirma Ekmekci S, G Ekmekci C, Kandilci A, Gulec C, Akbiyik M, Emrence Z, Abaci N,
Karakas Z, Agaoglu L, Unuvar A, Anak S, Devecioglu O, Ustek D, Grosveld G, Ozbek U. SET
oncogene is upregulated in pediatric acute lymphoblastic leukemia. SET oncogene is
upregulated in pediatric acute lymphoblastic leukemia.
Vural B, Yakar F, Derin D, Saip P, Yakar A, Demirkan A, Karabulut A, Ugurel E, Cine N,
Kilicaslan Z, Tüzün E, Ozbek U. Evaluation of glutathione S-transferase P1 polymorphisms
(Ile105Val and Ala114Val) in patients with small cell lung cancer. Genet Test Mol
Biomarkers. 2012 Jul;16(7):701-6.
EPICURE Consortium, Leu C, de Kovel CG, Zara F, Striano P, Pezzella M, Robbiano A,
Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus
V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuß-Lie AA, Hallman K, Kunz WS,
Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF,
Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac
S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A,
Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U,
Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman
BP, Sander T. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34
and 13q31.3 for genetic generalized epilepsies. Epilepsia. 2012 Feb;53(2):308-318
Gialluisi A, Pippucci T, Anikster Y, Ozbek U, Medlej-Hashim M, Mégarbané A, Romeo G.
Estimating the Allele Frequency of Autosomal Recessive Disorders through Mutational
Records and Consanguinity: The Homozygosity Index (HI). Ann Hum Genet. 2011 Dec 21.
doi: 10.1111/j.1469-1809.2011
Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K.
Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray CrossComplementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange
Frequency in Patients with Chronic Lymphocytic Leukemia. Genet Test Mol Biomarkers.
2011 Nov 22. [Epub ahead of print]
Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic alterations in members of the
Wnt pathway in acute leukemia. Leuk Lymphoma. 2011 Oct 24. [Epub ahead of print]
Vural B, Uğurel E, Tüzün E, Kürtüncü M, Zuliani L, Cavuş F, Içöz S, Erdağ E, Gül A, Güre
AO, Vincent A, Ozbek U, Eraksoy M, Akman-Demir G. Anti-neuronal and stress-induced-
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phosphoprotein 1 antibodies in neuro-Behçet's disease. J Neuroimmunol. 2011 Oct
28;239(1-2):91-7. Epub 2011 Aug 27.
Saip R, Sen F, Vural B, Ugurel E, Demirkan A, Derin D, Eralp Y, Camlica H, Ustuner Z,
Ozbek U. Glutathione S-transferase P1 polymorphisms are associated with time to
tumor progression in small cell lung cancer patients. J BUON. 2011 Apr-Jun;16(2):241-6.
Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S,
Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S,
Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of
leukemic B cells in the childhood B cell acute lymphoblastic leukemia. Leuk Res. 2012
Jan;36(1):87-92. Epub 2011 Aug 2.
Eskazan AE, Soysal T, Erbilgin Y, Ozbek U, Ferhanoglu B. Chronic myeloid leukemia
patients with F317L BCR-ABL kinase domain mutation are resistant to dasatinib: is that
true for all the patients? Leuk Res. 2011 Sep;35(9):e145-6. Epub 2011 May 24
Gormez S, Demirkan A, Atalar F, Caynak B, Erdim R, Sozer V, Gunay D, Akpinar B, Ozbek
U, Buyukdevrim AS. Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis
Factor-α and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease.
Intern Med. 2011;50(8):805-10. Epub 2011 Apr 15.
Ostergaard M, Nyvold CG, Jovanovic JV, Andersen MT, Kairisto V, Morgan YG, Tobal K,
Pallisgaard N, Ozbek U, Pfeifer H, Schnittger S, Grubach L, Larsen JK, Grimwade D,
Hokland P. Development of standardized approaches to reporting of minimal residual
disease data using a reporting software package designed within the European
LeukemiaNet. Leukemia. 2011 Apr 15
Bahat G, Saka B, Erten N, Ozbek U, Coskunpinar E, Yildiz S, Sahinkaya T, Karan MA. BsmI
polymorphism in the vitamin D receptor gene is associated with leg extensor muscle
strength in elderly men. Aging Clin Exp Res. 2010 Jun;22(3):198-205
Erbilgin Y, Sayitoglu M, Hatirnaz O, Dogru O, Akcay A, Tuysuz G, Celkan T, Aydogan G,
Salcioglu Z, Timur C, Yuksel-Soycan L, Ure U , Anak S, Agaogl S, Devecioglu O, Yildiz I,
Ozbek U, Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL.
Disease Markers 28 (2010) 1–8
Atalar F, Tevfik Acuner T, Cine N, Oncu F, Yesilbursa D, Ozbek U, Turkcan S.Two fourmarker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1
(KCNH2, Kv11.1) is related to schizophrenia: a case control study. Behav Brain Funct.
2010 May 28;6(1):27
Vural B, Demirkan A, Ugurel E, Kalaylioglu-Wheeler Z, Esen BA, Gure AO, Gül A, Ozbek U.
Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with
Behçet's disease. Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S67-72.
Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK,
Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U. Comparison of the
cytogenetic and molecular analyses in the assessment of imatinib response in chronic
myelocytic leukemia. Genet Test Mol Biomarkers. 2009 Oct;13(5):599-602.
Baccarani M, Rosti G, Castagnetti F, Haznedaroglu I, Porkka K, Abruzzese E, Alimena G,
Ehrencrona H, Hjorth-Hansen H, Kairisto V, Levato L, Martinelli G, Nagler A, Nielsen JL,
Ozbek U, Palandri F, Palmieri F, Pane F, Rege-Cambrin G, Russo D, Specchia G, Testoni N,
Weiss-Bjerrum O, Saglio G, Simonsson B. A comparison of imatinib 400 mg and 800 mg
daily in the front-line treatment of patients with high risk, Philadelphia-positive, chronic
myeloid leukaemia: a European LeukemiaNet study. Blood. 2009 May 7;113(19):4497504
Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E,
Ozbek U, Buyukdevrim AS. Presence of fatty-acid-binding protein 4 expression in human
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epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008 NovDec;17(6):392-8.
Ustuner Z, Saip P, Yasasever V, Vural B, Yazar A, Bal C, Ozturk B, Ozbek U, Topuz E.
Prognostic and predictive value of vascular endothelial growth factor and its soluble
receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients.
Med Oncol. 2008 ;25(4):394-9.
Chtcheglova LA, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdorfer P. Localization of the
ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM
recognition imaging. Pflugers Arch. 2008 Apr;456(1):247-54.
Ince AT, Hatırnaz O, Ovünc O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S,
IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease
Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2008
Jun;53(6):1683-92.
Sayitoğlu M, Ar MC, Hatırnaz O, Ongören S, Ure U, Başlar Z, Sırma,S Aydın Y, Özbek U,
Ferhanoğlu B. Minimal Residual Disease (MRD) Detection with Translocations and T-Cell
Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic
Leukaemia Patients: A Pilot Study. Turkish Journal of Hematology. 2008 25 (3): 124-132.
Ustek D, Sırma S, Cakiris A, Cosan F, Oku B, Ozbek U. Cloning of chimerical translocations
as positive control for molecular genetic diagnosis of leukemia. Turkish Journal of
Hematology. 2008 25 (1):20-23
Gazioglu NM, Erensoy N, Kadioglu P, Sayitoglu MA, Ersoy IH, Hatirnaz O, Kisacik B, Oz B,
Sar M, Ozbek U, Ciplak N, Cagatay P. Altered cyclin D1 genotype distribution in human
sporadic pituitary adenomas. Med Sci Monit. 2007 Oct;13(10):CR457-63.
Kadioglu P, Oral G, Sayitoglu M, Erensoy N, Senel B, Gazioglu N, Sav A, Cetin G, Ozbek U.
Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary.
2008;11(1):29-35.
Olcay A, Nişanci Y, Ekmekçi CG, Ozbek U, Sezer M, Umman B, Buğra Z. Angiotensinogen
M235T polymorphism and left ventricular indices in treated hypertensive patients with
normal coronary arteries. Anadolu Kardiyol Derg. 2007 Sep;7(3):257-61.
Ozbek U, Kandilci A, Van Baal S, Bonten J, Boyd K, Grosveld GC. SET-CAN, the product of
the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic
progenitors and proliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007
Aug;171(2):654-666.
Yonal O, Hatirnaz O, Akyuz F, Ozbek U, Demir K, Kaymakoglu S, Okten A, Mungan Z. HFE
Gene Mutation, Chronic Liver Disease, and Iron Overload In Turkey.Dig Dis Sci. 2007
Nov;52(11):3298-302.
Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, Ferhanoglu B, Ozcelik T, Ozbek U. The SOCS1
gene methylation in chronic myeloid leukemia patients. Am J Hematol. 2007
Aug;82(8):729-30.
Kalayoglu-Besisik S, Ozturk GB, Caliskan Y, Nalcaci M, Gurses N, Cin N, Ozbek U, Sargin
D.. Autologous stem cells collected after debulking by high dose chemotherapy in late
phase chronic myeloid leukemia may improve Imatinib efficacy. Transfus Apher Sci. 2007
Feb;36(1):91-4.
Ustek D, Ekmekci CG, Selcukbiricik F, Cakiris A, Oku B, Vural B, Yanar H, Taviloglu K,
Ozbek U, Gul A. Association between reduced levels of MEFV messenger RNA in
peripheral blood leukocytes and acute inflammation. Arthritis Rheum. 2007
Jan;56(1):345-50.
Olcay A, Ekmekci CG, Ozbek U, Sezer M, Barcin C, Arslan E, Boztosun B, Nisanci Y..
Negative association of endothelial nitric oxide gene polymorphism with hypertension in
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Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy.
Cardiovasc Ultrasound. 2006 Aug 21;4:33.
Aydin-Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U. Role of CYP2D6, CYP1A1, CYP2E1,
GSTT1 and GSTM1 Genes in the Susceptibility to Acute Leukemias. Am J Hemat, 2006
Feb 21;81(3):162-170
Olcay A, Nisanci Y, Ekmekci CG, Umman B, Bugra Z, Sezer M, Acar RD, Ozbek U.
Aldosterone synthase -344C/T and angiotensin-converting enzyme I/D polymorphisms in
Turkish hypertensive patients with normal coronary arteries. Acta Cardiol. 2006
Feb;61(1):29-34
Erkan E, Muslumanoglu AY, Oktar T, Sanli O, Ozbek U, Kadioglu A. Polymorphism of
endothelial nitric oxide synthase gene in patients with erectile dysfunction. J Sex Med.
2006 Jan;3(1):69-75.
Chan, AO, Soliman AS, Zhang, Q, Rashid A, Bedeir A, Houlihan PC, Mokhtar N, Al-Masri
N, Ozbek U, Yaghan R, Kandilci A, Omar S, Kapran Y, Dizdaroglu F, Bondy ML, Amos CI,
Issa JP, Levin B, Hamilton SR. Differing DNA methylation patterns and gene mutation
frequencies in colorectal carcinomas from Middle Eastern countries. Clin Cancer Res.
2005 Dec 1;11(23):8281-7.
Einav U, Tabach Y, Get G, Yitzhaky A, Ozbek U, Amariglio N, Izraeli S Rechavi and
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Domany E. Gene expression analysis reveals a strong signature of an interferon induced
pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer.
Oncogene. 2005 Sep 22;24(42):6367-75.
Vural B, Chen L, Saip P.3, Chen Y , Ustuner Z.3, Gonen M, Jager E, Simpson AJ; Old LJ,
Ozbek U, Gure AO. Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish
SCLC patients and their correlation with clinical parameters. Cancer, 2005, May; 103
(12):2575-2583
Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K,
Cleveland JL, Grosveld GC. The Novel ETS Factor TEL2 Cooperates with Myc in B
Lymphomagenesis. Mol and Cell Biol. 2005 Mar; 25(6): 2395–2405
Aydin-Sayitoglu M, Yildiz I, Hatirnaz O, Ozbek U. Common Cytochrome p4503A (CYP3A4
and CYP3A5) and thiopurine S-methyl transferase (TPMT) polymorphisms in Turkish
population. Turk J Med Sci, 2005 35:1-5
Bebek N, Cine N, Oner GO, Eskazan E, Ozbek U. Genotype and allele frequencies of MDR1 C3435T polymorphism in Turkish population. Journal of Neurological Sciences
2005;22(3): 261-266
Akyerli CA, Beksac M, Holko M,d, Frevel M, Dalva K, Ozbek U, Soydan E, Ozcan M, Ozet
G, Ilhan O, Gurman G, Akan H, Williams BRG, Ozcelik T. Expression of IFITM1 in chronic
myeloid leukemia patients. Leukemia Research 29 (2005) 283–286
Aşıcıoğlu F, Oğuz-Savran F, Ozbek U. Mutation rate at commonly used forensic STR loci:
paternity testing experience. Disease Markers 2004, 20(6): 313-315.
Aydin M, Hatirnaz O, Erensoy N, Ozbek U. CYP2D6 and CYP1A1 mutations in the Turkish
population. Cell Biochem Funct. 2005 Jan 13; 23(2):133-135
Ekmekci CG, Gutierrez MI, Siraj AK, Ozbek U, Bhatia K. Aberrant methylation of multiple
tumor suppressor genes in acute myeloid leukemia. Am J Hematol. 2004 Oct
19;77(3):233-240
Sirma S, Agaoglu L, Yildiz I, Cayli D, Horgusluoglu E, Anak S, Yuksel L, Unuvar A, Celkan T,
Apak H, Karakas Z, Devecioglu O, Ozbek U. NAD(P)H:quinone oxidoreductase 1 null
genotype is not associated with pediatric de novo acute leukemia. Pediatr Blood Cancer.
2004 Oct;43(5):568-70.
58. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Salcioglu Z, Sarper N, Ozbek U. Real-Time
PCR analysis of af4 and dek genes expression in acute promyelocytic leukemia t(15;17)
patients. Exp Mol Med. 2004 Jun 30;36(3):279-82.
59. Savlı H, Sırma S, Nagy B, Aktan M, Dinçol G, Salcioglu Z, Ozbek U. Expression analysis of
DEK, AF4 and FLI1 genes in all-trans-retioic acid (ATRA) treated acute promyelocytic
leukemia t(15;17) patients by quantitative real-time PCR. Turk J Med Sci. 2004, 34: 8560. Duymaz-Tozkir J, Gul A, Uyar FA, Ozbek U, Saruhan-Direskeneli G. Tumour necrosis
factor-alpha gene promoter region -308 and -376 G-->A polymorphisms in Behcet's
disease. Clin Exp Rheumatol. 2003 Jul-Aug;21(4 Suppl 30):S15-8.
61. Kalayoglu-Besisik S, Caliskan Y, Sargin D, Gurses N, Ozbek U. Methylenetetrahydrofolate
reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell
transplantation. Transplantation. 2003, 27;76(12):1775-7.
62. Savlı H, Sırma S, Aktan M, Dinçol G, Özbek U. Quantification of all-trans-retinoic acid
dependent expression of CXCR4 gene in acute ptomyelocytic leukaemia. Turk J Haematol
2003, 20(3): 153-159.
63. Savlı H, Sırma S, Ozbek U. Identification of the FLI-1 gene expression by real-time
quantitative RT-PCR. Turk J Med Sci 2003, 33:21-25.
64. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U. Real-time PCR analysis of the
apoptosis
related
genes
in
ATRA
treated
APL
t(15;17)
patients.
Exp Mol Med. 2003, 31;35(5):454-9.
65. Gutierrez MI, Siraj AK, Bhargava M, Ozbek U, Banavali S, Chaudhary MA, El Solh H,
Bhatia K. Concurrent methylation of multiple genes in childhood ALL: Correlation with
phenotype and molecular subgroup. Leukemia. 2003, 17(9):1845-50.
66. Akyerli CB, Ozbek U, Aydin-Sayitoglu M, Sirma S, Ozcelik T. Analysis of MYH Tyr165Cys
and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol. 2003,
129(10):604-5
67. H. Savlı, A. Karadenizli, F. Kolaylı, S. Gündes, U. Ozbek, H. Vahaboglu. Expression stability
of six housekeeping genes: a proposal for resistance gene quantification studies of
Pseudomonas aeruginosa by real-time quantitative RT-PCR. Journal of Medical
Microbiology, 2003, 52: 1-6.
68. U. Özbek, Sırma S, Ağaoğlu L, Yüksel L, Anak S, Yıldız I, Devecioğlu O, Timur Ç, Meral A,
Gedikoğlu G. Prognostic significance of the TEL-AML1 fusion gene in pediatric acute
lymphoblastic leukemia in Turkey. J Pediatr Hematol/Oncol, 2003, March; 25(3): 204208.
69. Onay UV, Kavakli K, Kilinc Y, Gurgey A, Aktuglu G, Kemahlı S, Ozbek U, Caglayan
SH.Molecular pathology of haemophilia B in Turkish patients: identification of a large
deletion and 33 independent point mutations. Br J Haematol. 2003 Feb;120(4):656-659
70. Siraj A.K., Ozbek U., Sazawal S., Sırma S., Timson G., Al-Nasser A., Bhargava M., El Solh
H., Bhatia K., Gutierrez M.I. Preclinical validation of a monochrome real-time multiplex
assay for translocations in childhood acute lymphoblastic leukemia. Clinical Cancer
Research, 2002, Dec;8(12):3832-40.
71. Asicioglu F, Akyuz F, Cetinkaya U., Yılmaz S., Koluacık S., Vural B., Ozbek U. Turkish
population data on nine short tandem repeat loci: HumCSF1PO, HumTHO1, HumTPOX,
HumFES/FPS, HumF13B, HumVWA, D3S1358, D7S820, D16S539. Forensic Sci Int
126(3):252-253, 2002
72. Asicioglu F, Akyuz F, Cetinkaya U, Ozbek U. Allele distribution data of nine short tandem
repeat loci for Turkish population: WS1358, vWA, FGA, D8S1179, D21S11, D18S51,
D5S818, D13S317, D7S820. Forensic Sci Int 129 (1): 75-77 2002
73. B. Ömer, U. Özbek, A.Akköse, G. Kılıç. Genetic polymorphism of cytochrome p450 2E1 in
the Turkish polulation. Cell Biochem Function 2001, 19(4):273-275
74. Günay, A. Öztürk, T.Budak, U. Özbek, N. Üskent. Activated protein C resistance in
polycythemia vera. Turk J Haematol 2001;18(3):157-164
75. U.Özgen, S. Anak, U. Özbek, Nazan Sarper, E. Eryilmaz, L. Agaoglu, Ö. Devecioglu, N.
Yalman, G. Gedikoglu: Prognostic significance of Wilms tumor 1 gene in childhood acute
lymphoblastic leukemia. Turk J Haematol 2000, 17(4):183-188.
76. N. Sarper, U. Ozbek, L. Agaoglu, U. Ozgen A. Kandilci, S. Sirma, S. Anak, N. Yalman, E.
Eryilmaz, O. Devecioglu, G. Gedikoglu. Detection of BCR/ABL trascripts by reverse
transcriptase polymerase chain reaction in pediatric acute lymphoblastic leukemia:
Incidence and clinical features. Turk J Haematol 2000, 17(4):197-206.
77. Sarper N, Özbek U, Agaoglu L, Ozgen U, Eryilmaz E, Yalman N, Anak S, Devecioglu O,
Gedikoglu GIs AML1/ETO gene expression a good prognostic factor in pediatric acute
myeloblastic leukemia? Pediatr Hematol Oncol. 2000 Oct-Nov;17(7):577-83.
78. Özgen U, Anak S, Özbek U, Sarper N, Eryilmaz E, Agaoglu L, Devecioglu O, Yalman N,
Gedikoglu G. WT1 gene expression in childhood acute leukemias. Acta Haematol.
2000;103(4):229-30.
79. Sarper N, Özbek U, Agaoglu L, Ozgen U, Devecioglu O, Kandilci A., Sırma S., Karakas Z.,
Yalman N, Anak S, , Gedikoglu. Clinical outcome of children with ALL-AF4 positive acute
lymphoblastik leukemia. Haema. 2000; 3(2): 102-106.
80. F. Yesim, K. Demirci, D.B. Guney, K. Akarcay, N. Kir, U. Ozbek, S. Sirma, N. Unaltuna, E.
Ongor. Revalence of factor V Leiden in patients with retinal vein occlusion.Acta
Ophthalmol Scand. 1999 Dec;77(6):631-3.
81. Elter K, Erel CT, Cine N, Ozbek U, Hacihanefioglu B, Ertungealp E. Role of the mutations
Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women
with polycystic ovary syndrome. Fertil Steril. 1999 Mar;71(3):425-30.
82. Dincol G, Nalcaci M, Yavuz AS, Keskin H, Aktan M, Dogan O, Agan M, Ozbek U, Dincol
K.Case of hepatosplenic gammadelta T-cell lymphoma presenting with severe
hypersplenism.. Am J Hematol 1999 Apr; 60(4):313-4.
83. U. Özbek, B. Vural, S. Kalayoglu, T. Soysal, S. Anak, D. Sargýn, G. Gedikoglu, T. Akoglu, B.
Ferhanoglu, Y. Tangün, T. Özçelik: Evaluation of chimerism with DNA polymorphisms in
bone marrow transplantation. Turk J Pediatr. 1997 Jul; 39(3): 303-311.
84. U. Özbek, Y. Tangün: Frequency of factor V Leiden (Arg506Gln) in Turkey. Br J Haematol.
1997 May; 97(2): 504-505.
85. A. Gul, U. Özbek, C. Oztürk, M. Inanç, M. Konice, T. Ozçelik: Coagulation factor V gene
mutation increases the risk of venous thrombosis in behcet's disease. Br J Rheumatol.
1996 Nov; 35(11): 1178-1180.
86. H. Yazici, M. Müslümanoglu, D. Güzey, V. Yasasever, U. Özbek, N. Dalay: Amplification in
tumors and benign tissue of breast cancer patients. Cancer Lett. 1996 Oct 22; 107(2):
235-239.
87. U. Özbek, Y. Tangün: Frequency of factor V Leiden in Turkey. Int J Hematol. 1996 Oct;
64(3-4): 291-292.
88. G. Ogur, Z. Sengün, G. Arel-Kiliç, C. De Busscher, S. Basaran, U. Özbek, I. Ayan, E. Sariban,
E. Vamos: Clinical and cytogenetic studies of two cases of Klinefelter syndrome with
hereditary retinoblastoma and rhabdomyosarcoma. Cancer Genet Cytogenet. 1996 Jul 1;
89(1): 77-81.
89. S. Savasan, B. Zulfikar, A. Ozgeneci, U. Özbek, Z. Sengun: Monosomy 7
myeloproliferative disease associated with neurofibromatosis type I: a case report.
JChemother.1996 Jun; 8(3): 243-246.
90. G. Ogur, Z. Sengün, H. Onat, U. Özbek, G. Erseven, I. Ayan, S. Kurul, R. Kebudi, S. Inanç:
Correlation of chromosomal changes with morphological classification in non-Hodgkin’s
lymphoma. Turkish Journal of Oncology, 10(4):56-62 (1995).
PROFESSIONAL MEMBERSHIPS:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
The Human Genome Organization (HUGO)
American Society of Human Genetics (ASHG)
American Association for Cancer Research (AACR)
American Society of Hematology (ASH)
European Hematology Association (EHA)
European Society of Human Genetics (ESHG). PPLC committee member
Turkish Society of Hematology (THD). Board member-Treasurer. 2001-2005
Turkish Society of Genetics (TGD). Board member 2007-2009
Turkish Oncology Foundation (TOV)
Turkish Society of Epilepsy