Twenty-First Century Images the of
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Twenty-First Century Images the of
Images of the Twenty-First Century Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 11: 1989 Seattle, Washington • November 9-12, 1989 EDITED BY Yongmin Kim Francis A. Spelman 89CH2770-6 UNIVERS1TATSBIBLIOTHEK HANNOVER TECHNISCHE INFORMATIONSBIBLIOTHEK Part 1/6 THIS PART CONTAINS: Track 1. Cardiology Track 3. Physiological Control Systems Track 19. & Models Sleep & Respiration 0. Images ofthe Twenty-First Century TABLE OF CONTENTS Part 1/6 THIS PART CONTAINS: Track 1, Track 3. Physiological Control System Track 19. Eli Cardiology Lilly & Chair: Francis A. & Models Sleep & Respiration Co. Session Plenary Spelman, University of Washington Technologies and Health Care in the 21st Century Bioengineering, University ofWashington RF Rushmer, MD, Center for 1 Panel Discussion Meet the Editors of IEEE Transactions in Biomedical Western Reserve Engineering MR Neuman, Case 3 University Track 1: Cardiology Chair: Susan M. Blanchard Session 1.01: Heart Rate Session Chair: 1. Variability Stanley Reisman, New Jersey Institute of Technology Assessment of the HR Baroreflex in Human Identification M Subjects Using Appel, Harvard-MIT Division of Health Parametric Science & System Technology; 4 JP Saul, RD Berger, RJ Cohen 2. A Personal New Computer Jersey System for Heart Rate Variability Studies JA Zelano, ofTechnology; R Mackintosh, J Hirsch Based Institute 3. Spectrum Analysis of Heart Rate Variability X. Wang, Technology; SS Reisman, WN Tapp, BH Natelson New Jersey Institute of 4. Signal Analysis of Rhythmical Discharge in Cardiac Preganglionic Fibers and of Heart Rate Variability G Baselli, Universita Brescia, Italy; S Cerutti, LM 6 8 10 Finocchiaro, F Lombardi, A Malliani, N Montano IEEE EMBS 1989—xi 5. Power Spectrum Analysis of Heart Rate Variability Signal in the Diagnosis 12 of Diabetic Neuropathy S Cerutti, Politecnico, Milano, Italy; A Bianchi, B Bontempi, 6. G Comi, P Gianoglio, MGN Sora Using Breathing Bursts as Dwyer, Cornell University Medical College; Y Noguchi, HH Szeto Spectral Analysis Session 1.02: ECG of Heart Rate Variability Signal Processing a Time Base G 14 I Session Chair: Edward J. Berbari, VA Medical Center & University of Oklahoma HSC 1. Ropella, KM 16 RC Barr, B 18 Segmentation on Coherence Estimates of Cardiac Rhythms University; AV Sahakian, JM Baerman, S Swiryn Effect of Data Northwestern Design for Fan Adaptive Sampling Sacks, WT Krakow 2. A VLSI 3. Optimizing Signal Averaging Methods P LN Bohs, Duke University; Lander, University of Oklahoma Health 19 Science Center; EJ Berbari 4. Signal Averaged Health Science Center 5. Quality Control EJ Berbari, University of Oklahoma & VA Med. Center; P Lander ECG's and Enhancement of Surface HIS 21 22 Activity with Adaptive Filtering GGCano, Allegheny-Singer Research Institute, Pittsburgh; SA Briller 6. A Technique for the Determination of Left Ventricular Mass by Signal-Averaged Electrocardiography GWBotteron, University of Kansas Medical Center; Vacek, DB Wilson, SL Lawhorn Session 1.03: ECG Signal Processing 24 JL H Session Chair: Sergio Cerutti, Politecnico di Milano, Italy 1. Comparison of Individual Lead and Combined Lead Frequency Parameters of Signal Averaged Electrocardiograms MS Fuller, University of Utah; RAFreedman, D 26 Barton 2. Detection of Late Potentials by Means of Wavelet Transform OMeste, ofNice, France; H Rix, R Jane, P Caminal 3. Signal Averaging and Shape Classification Thierry, P Caminal, H Rix, University ofNice, France; Recognition Technique to QRS Complex Classification Chung Yuan Christian University, Taiwan; KP Lin, RY Lee Pattern 5. QRS Detection Based on Hidden Markov Modeling Research Institute, Pittsburgh; GG Cano 6. The Design of a Pipeline Processor for Xii—IEEE an DA 1989 WH Chang, Coast, Allegheny-Singer Automated ECG University, Korea; YS Lee, HR Yoon, MH Lee EMBS E 28 30 R Jane 4. Yonsei University Diagnosis KJLee, 32 34 36 Session 1.04: ECG Signal Processing m Session Chair: Willis J. Tompkins, University of Wisconsin - Madison 1. Real-Time 2. Spectral Analysis of Cardiac Cycle Length Variations: Resampling Overcomes Early Detection of R Waves of ECG Signals Scientific, Inc.,Mansfield, MA; Y Sun, JA Beyer Effects of Nonuniform Spacing KL Schreibman, University; CW Thomas, MN Levy 3. 4. A New Algorithm for University, Korea; Heart Rate P-Wave Detection in the ECG KK Kim, Variability System Silesian Technical SC TA Wrublewski, Mansfield 38 40 Case Western Reserve 42 Signal HKJoeng, Yonsei Hwang, MH Lee Based on University, Poland; Microcomputer IBM PC/XT ETkacz, 44 P Antosz 5. Discriminant Analysis of HRV's Auto Regressive Model Coefficient for Cardiac Arrhythmia YS Lee, Yonsei University, Korea; KJ Lee, HR Yoon 47 6. Real-Time Base-line Drift Correction and P-Wave Detection of ECG 49 Tsinghua University, China; Signal LZhou, HJ Li, GS Hu Session 1.05: Heart Sounds Session Chair: John L. Semmlow, Rutgers University 1. Parametric Modeling of Diastolic Heart Sounds: Before and After Angioplasty Akay, Rutgers University; JL Semmlow, W Welkowitz, J Kostis 2. Pattern 3. Study M Recognition of Normal, Lightly and Heavily Calcified Bioprosthetic Valves Implanted in the Mitral Position LG Durand, Clinical Research Institute of Montreal; M Blanchard, G Cloutier, HN Sabbah, PD Stein on the Generation of Closing Sound from Metallic Prosthetic Heart H Koymen, Middle East Technical University, Turkey; Ider, Y Zorlutuna, O Tasdemir, T Tezcaner, K Vural Implants A Valve Baykal, 4. High Sensitivity PCG Transducer for Extended Frequency Applications V Padmanabhan, Rutgers University; R Fischer, JL Semmlow, W Welkowitz 5. The Effects of Inertia on the 51 S3 55 YZ 57 Mechanics of the Left Ventricle During the Isovolumic 59 Phases M Lewkowicz, Theoretical Biomechanics Group, NIH; RS Chadwick 6. Processing and Session 1.06: Cardiac of Foetal Analysis Edinburgh, UX.; JH Dripps, Phonocardiograms 61 McDonnell, University of E P Grant Doppler Session Chair: Louis-Gilles Durand, Clinical Research Inst, of Montreal 1. Computer Aided Pattern Recognition & 3D Reconstruction of Carotid Stenosis Greene, University of Washington; DJ Phillips, K Beach, J Primozich, DE FM 63 Strandness, Jr. 2. Parametric Stenosis 3. Velocity Fields in the Region of SERittgers, University of Akron; DYFei Analysis of a Modeled Carotid Artery Characterization of Spectral Broadening of Doppler Signals G Cloutier, Clinical Research Institute ofMontreal; FLemire, LG Durand, Y Latour, M Jarry, A Solignac, L Allard, YE 65 67 Langlois IEEE EMBS 1989—Xiii 4. Quantitative Analysis of Doppler Flow Spectra in the Lower Limb Arteries LAllard, Clinical Research Institute ofMontreal; YE Langlois, LG Durand, GO Roederer, M Beaudoin, G Cloutier, P 5. An R Robillard Spectral Analysis of Ultrasonic Doppler Blood Flow Minimum Variance Method in 71 K Kaluzynski, Warsaw Technical University, Poland Velocity Signal 6. Roy, 69 Implantable Multichannel Ultrasonic Pulsed Doppler Blood Yeung, Stanford University; JJ Sebek, JD Meindl Flowmeter KW 73 Session 1.07: Ventricular Defibrillation Session Chair: Nitish V. Thakor, Johns Hopkins University 1. Computer Simulation of DefibriUating Electric Shocks: Critical Mass PM Auger, Faculte de Pharmacie, Dijon, France; A Bardou, A Coulombe, MC Govaere, JM Chesnais, D Von Euw 2. Experimental Results Pertinent to the Modelling of Defibrination RE Ideker, 75 77 Duke University Medical Center; W Krassowska, JM Wharton, WM Smith 3. Physio-Control 4. Corp., Redmond, WA; RL Barker Strength-Duration Relationship for Biphasic Defibrillation in Dogs DJ Lang, Cardiac Pacemakers, Inc. St. Paul, MN; DK Swanson, SM Bach, Jr., JE 5. Curve 80 Shapland 82 Fitting Defibrillation Success Rate Versus Energy BEGliner, Johns Hopkins University; 6. 79 Three-Dimensional Finite Element Model of Human Thorax M Ahmed, Y Murakawa, NV Thakor The Fundamental Law of Electrostimulation WEIrnich, Justus-Liebig-University, 84 FRG Session 1.08: Ventricular Session Chair: Steven 1. Swiryn, Tachycardia & Fibrillation Northwestern Patterns of Activation During University of California, University Ventricular Fibrillation in San Diego; SJ Worley, Open Chest Dogs PS Chen, 2. Imaging of Atrial Fibrillation in Man MAAllessie, University of Limburg, Netherlands; J Brugada, CJH Kirchhof 3. Computer Modeling of the Initiation of Myocardial George's Hospital, London; AJCamm 4. Fibrillation Kaplan, 5. vs. Fibrillation M Malik, The 88 St. 90 Random Noise: A Comparison Using Dimensionality Calculations DT Massachusetts Institute Tachyarrhythmia of Technology; 86 RE Ideker 92 RJ Cohen Threshold of Ischemic Heart in 3-Dimensional Computer Model 94 MG Fishier, Johns Hopkins University; NV Thakor 6. Computer Model of the Effects of Overdrive Pacing During Atrioventricular Reentrant Tachycardia M Malik, St. George's Hospital, London; AJCamm xiv--IEEE EMBS 1989 96 Session 1.09: Cardiovascular System Dynamics Session Chair: Wolf von Maltzahn, 1. Dynamics of Intraaortic University of Texas I Arlington at Counterpulsation with Double-Segmented Balloons PC Nardella, Medical Scientific, Inc., Mansfield, MA; 2. Mitral Pressure Half-time 98 Y Sun, TA Wrublewski Technique for Assessing Severity of Mitral Stenosis: Loyd, Linkoping University, Sweden; P Ask, B Wranne 100 the Pressure Drop-Flow Relationship of a Compliant Coronary 101 Essential Parameters D 3. In Vitro Study on Stenosis MSiebes, University of Southern California; DZD'Argenio 4. Theoretical and Experimental Analysis of Aortic Coarctation University, Sweden; J Engvall, D Loyd, B Wranne 5. State-Space Analysis of Ventricular/Vascular Coupling YSun, University of P 103 Ask, Linkoping 104 Rhode Island 6. Right Ventricular/Vascular Coupling During Acute Pulmonary Hypertension Fourie, University of Stellenbosch, South Africa; AR Coetzee, A Rebel, CT P 106 Bolliger Session 1.10: Cardiovascular System Dynamics II Session Chair: John K.-J. Li, Rutgers University 1. Comparison of Techniques for Assessing Pulmonary Input Impedance Spectra B Ha, University of North Carolina, Chapel Hill; CL Lucas, GW Henry, EG Frantz, JI 108 Ferreiro, R Seven, BR Wilcox 2. Variation in Emax of the Left Ventricle Among Mammals GM DrzewiecM, Rutgers University; N Krawciw, JK Li, W Welkowitz 3. Real-Time RD 4. Loading of the Isolated Heart with a Wave Transmission Arterial Kirkpatrick, Washington State University; H Taheri, KB Campbell Model-Based Parameters and Indices for Rutgers University; 5. 110 PS Assessing the Cardiovascular State CP Falkenhagen, G Drzewiecki Model JK 112 114 Li, Geipel, DS Berger, Reproducibility of Arterial Vascular Compliance Measurements SM Finkelstein, University ofMinnesota; GE McVeigh, DE Burns, KM McDonald, PF Carlye, JN 116 Cohn Session 1.11: Modeling of Left Ventricular Mechanics Session Chair: Herman B.K. Boom, University of Twente, The Netherlands 1. Cascaded Constant Flow Pulses as a Tool for Wijkstra, Radboud University Hospital, 2. Analyzing Ventricular Mechanics The Netherlands; H 118 DL Bell Kinetic Models for Pressure Response to Volume Change in Tetanized Isolated Heart KB Campbell, Washington State University; DL Bell, JA 120 Ringo 3. Effects of Arterial Load Changes on Systolic Pump Function JBaan, Leiden University Hospital, The Netherlands; ET Van Der Velde, LP Van Der Linden 122 4. An Ellipsoidal Shell Subtraction Model of the Right Ventricle: Validation and Application In Vivo MP Feneley, St. Vincent's Hospital, Durham, NC; JR Elbeery, JS Rankin 124 IEEE EMBS 1989—XV 5. Identification of Left Venticular Model Parameters HBK Boom, University of Twente, The Netherlands; HWijkstra Session 1.12: Noninvasive Cardiovascular Session Chair: 1. 126 Dynamics Gojmir Juznic, Institute of Physiology, Ljubljana, Yugoslavia The Use of a Continuous Non-invasive Blood Pressure Recorder to Study Experimental Stressors PJPretorius, University of Christian Higher Education, 128 South Africa; NT Malan, HW Huisman, PJ Laubscher, FC Etoff, FAJ de Klerk, SJ van 2. der Merwe A Positive Feed-back Mechanism Enhancing the Heart Beat G Juznic, Institute of Physiology, Ljubljana, Yugoslavia; 3. I Bardorfer, J Pecar, Left Ventricular Function in Patients with 130 D Peterec Attempted Coronary Reperfusion I V Fidler, M Porenta, 132 Kranjec, University Medical Center, Ljubljana, Yugoslavia; A Janezic 4. A Noninvasive Method for Measuring Regional Peripheral Compliance EA Lopez-Beltrao, University ofMinnesota; PL Blackshear, SM Finkelstein 5. Evaluation of Arterial Pulse Wave Velocity on the Basis of Multivariate Analysis M Okada, Niigata University School of Medicine, Japan; 6. 134 136 M Okada, M Yakata Non-Invasive Assessment of Myocardial Function HKesteloot, Katholieke 1-AP-l University, Leuven, Belgium Session 1.13: ECG Signal Processing Session Chair: Susan M. Blanchard, Duke 1. A Real-Time IV University Medical Center QRS Detection and Delineation Algorithm Based on the Inflection Angle HSHsiung, National Taiwan University, Taiwan; CK 138 of the ECG Waveform Cheng, 2. GJ Jan Hungary; 3. Arrhythmia Processing System Velkei, F Marton, J Tenczer New Interactive I Detection of Ventricular Fibrillation Using M Rohla, Semmelweis University, the Autocorrelation Function the ECG SG Guillen, Universidad Politecnica de Valencia, Spain; Analysis of 140 141 MT Arredondo, G Martin, JM Ferrero Corral 4. Detection of VF Signal by an M-ary Sequential Detection YZhu, University of Science & Technology ofChina, China 143 5. Knowledge Based Refining of K-NN Fuzzy Classifier: A Case Study in Ventricular Arrhythmia Diagnosis DCabello, Universidad de Santiago, Spain; SBarro,JM Salceda, R Ruiz, J Mira 145 6. Stabilizing Institute XVi—IEEE the Rate—A Straight Cortical Repercussion upon the Heart RMNegoescu, of Hygiene and Public Health, Romania; IE Csiki, M Pafhote EMBS 1989 147 Session 1.14: Artificial Hearts Session Chair: Joshua E. Tsitlik, Johns Hopkins University 1. 2. Development of the Physiological Control Scheme for Artificial Heart PKhanwilkar, University of Utah; Smith, DB Olsen Parameter Estimation of the an Electrohydraulic Total Crump, GB Bearnson, JK 149 KR Systemic Arterial Bed for Control of a Total Artificial 151 Heart TL Ruchti, Marquette University; RH Brown, X Feng 3. A 4. A DC/DC Resonant Power Converter for an Electric Artificial Heart J Range of Artificial Hearts LS Yu, A CMOS WJKolff 153 154 Cerny, DC Jeutter Marquette University; 5. University of Utah; Microcontroller Based PCM Encoder for Use with a Total Artificial Heart 157 AR Khomeshwari, Marquette University; DC Jeutter Session 1.15: Cardiac Assist Devices Session Chair: Dov Jaron, Drexel 1. Effects of the Device 2. System Timing on the Performance of a New Mechanical Cardiac Assist T Cui, Rutgers University; W Welkowitz, JKJ Li, S Petrucelli Prosthetic Valve Selection for a Pulsatile LVAD SGKovacs, University of South New LE Ondrovic, Coating Materials for 164 Artificial Heart Valves ABolz, M Schaldach In Vitro Assessment of the Flow Characteristics of the Central-Axis Prosthetic Heart Valve AAH Mansour, 5. 162 RG Connar Friedrich-Alexander-University Erlangen-Nurnberg, FRG; 4. 160 (MCAD) Florida; 3. University The Optimal Operating Point of the Ventricular Assist Device M Yoshizawa, University, Japan; H Takeda, JS Feng, S Nitta Tohoku Session 1.16: Databases in Session Chair: Francesco 169 Cardiology Pinciroli, Politecnico di Milano, Italy 1. MSx2/cardio: An Implementation of a Multiservice Medical Software Politecnico di Milano, Italy; C Combi, G Pozzi, R Rossi 2. Implementation of Regional Registry of Acute Myocardial Infarction (R.I.M.A.R Study) MBossi, Saronno Hospital, Italy; C DeVita, MD Etro 3. CADANS - 167 King Saud University, Saudi Arabia; A Customized Network for Interuniversity Cardiology Institute, Cardiology F Pinciroli, 171 173 in the Netherlands GT Meester, 175 The Netherlands; OEH Sartorius, D Fanggidaej, MGJ Gerritsen 4. A Teaching-Oriented Knowledge-Database for Clinical Arrhythmology T Carazza, 177 Politecnico di Milano, Italy; L Ballardini, C Busetti, F Pinciroli Session 1.17: Forward Problem in Session Chair: Ramesh M. 1. Electrocardiology Gulrajani, Hopital Computer Simulations du Sacre-Coeur, Montreal of Excitation in an Anatomically Based Model of the Human 179 Ventricular Conduction System AE Pollard, Duke University; RC Barr IEEE EMBS 1989- -xvii 2. Dynamic Simulation of Electrical Tokyo 3. Institute Phenomena in the Human Heart of Technology, Japan; Interactive Simulation of the Wei, D QRS Waveforms 181 TMusha, K Harumi A van 183 Oosterom, University of Nijmegen, The Netherlands Myocardial Anisotropy on Body Surface Potentials Using an Eccentric Spheres Model JA Schmidt, Duke University; TC Pilkington 185 A Simulation 186 4. The Effects of 5. Evaluation of the Study D Rotating Anisotropy of the Ventricular Myocardium: Wei, Gakken Co., Ltd., Japan; G Yamada, K Hasegawa, T Nakamura, T Musha 6. ECG Simulations with Lorange, Session 1.18: Ecole a Heart Model Polytechnique Incorporating Myocardial Anisotropy M 188 Gulrajani de Montreal; RM Electrocardiographic Mapping I Session Chair: Giorgio Arisi, Institute di Fisiologia, Parma, Italy 1. Forward Electrocardiography Based on Measured ofNijmegen, The Netherlands; A van Oosterom 2. Localization of Ventricular Ectopic Beats from Data G Huiskamp, University Intracavitary Potential Distributions: An Inverse Model in Terms of Sources E Macchi, Universita 189 191 Degli Studi, Italy; G Arisi, P Colli-Franzone, L Guerri, G Olivetti, B Taccardi 3. Inverse Epicardial Potential Solutions with an Isolated Heart Preparation B Soucy, 193 Ecole Polytechnique de Montreal; RM Gulrajani, R Cardinal 4. Rapid Localization of Accessory Pathways in W*PW Syndrome Using Unipolar Potential Mapping RLLux, University of Utah; PR Ershler, KP Anderson, JW 195 Mason 5. Intracardiac and Extracardiac Potential Distributions Beats B Taccardi, University of Utah; RL Lux, PR During Ershler, Ventricular B Ectopic Steadman, S 197 Watabe 6. Beat-to-Beat Measurement of Epicardial Conduction and Repolarization In Vivo in the Session 1.19: Electrocardiographic Mapping Session Chair: Emilio Macchi, Institute di Digital H 2. Interactive Cardiac Mapping I: Data Conversion of an Analog Cardiac Mapping Approach Polytechnical Institute, Canada; E Downar G Sun, CW Thomas, M I Parson, Ryerson Acquisition K Laurita, Case Western Reserve Kavuru, J Liebman, AL Waldo 3. Interactive Cardiac Mapping H: Data Analysis GSun, Case Western Reserve University; K Laurita, CW Thomas, J Liebman, J Wang, AL Waldo 4. Use of 5. Automatic Analyzer for Bipolar Cardiac Electrograms WM Smith, University Medical Center; EV Simpson, ND Danieley, RE Ideker an Duke On-Line Mapping of Cardiac Arrhythmias in Man MAAllessie, University of Limburg, The Netherlands; APG Hocks, GML Schmitz, Smeets, O Penn, CJHKirchof xviii—IEEE 199 Fisiologia, Parma, Italy 1. University; Anisotropy Dog FXWitkowski, University ofAlberta; PAPenkoske EMBS 1989 SJ Hollen, H Jas, JLR 202 204 206 208 l-AP-2 Session 1.20: Electrocardiographic Mapping III Session Chair: Susan M. Blanchard, Duke University Medical Center 1. A Multi-Processor Approach to Real Time Body Surface Potential Mapping M Clarke, Brunei University, UK.; RW Jones 213 2. Time-Dependent Clinical Indices of Body Surface Potential Maps Technion-HT, Israel; S Gilat, S Sideman 215 3. Using Impedance Imaging to Determine Intracavitary Probe Location Duke University; TC Pilkington, SL Tyler 4. Real Time Measurement of Intracavitary Probe Position SKun, Worcester Polytechnic Institute; RA Peura 218 5. Silicon Based Electrode Arrays RB Ash, North Carolina State Wortman, HT Nagle, JW Buchanan 210 6. Thin-Film Flexible Multielectrode Mastrototaro, Duke University; DR Adam, DL 217 Derfus, University; JJ Arrays for Voltage Measurements in the Heart JJ TC Pilkington, 212 RE Ideker, HZ Massoud Session 1.21: Analysis of Cardiac Electrograms Session Chair: William M. Smith, Duke University Medical Center 1. Local and Distant Components of Bipolar Cardiac Electrograms SM Blanchard, Duke University Medical Center; PJ Hendry, JS Kabas, PK Smith, JE Lowe, WM 220 Smith 2. Data Analysis 222 3. Adaptive Coherence Estimation on Brief Intracardiac Recordings A Sahakian, Northwestern University; K Ropella, J Baerman, S Swiryn 224 4. Computing ROC Curve Confidence Intervals for Cardiac Activation 226 Techniques for Measuring Spatial Inhomogeneity in Repolarization Using Optical Transmembrane Potentials G Salama, Massachusetts Institute of Technology; DS Rosenbaum, A Kanai, RJ Cohen, DT Kaplan Simpson, Duke University Medical Center; 5. Automated Interactive Cardiac University of South 6. Arrhythmia Sensing Detectors EV RE Ideker, KL Lee, WM Smith Electrophysiology Testing DS Buckles, Medical 228 Carolina and Detection RMT Lu, Telectronics by a Software-Based Arrhythmia Control System Pacing Systems, Sydney, Australia; P Haeusler, R 230 McCulloch Track 3: Physiological Control Systems Chair: JoelB. Session 3.01: Electric and Session Chair: Joel B, 1. Myklebust Magnetic Stimulation Myklebust, Medical College Finite Element and Models of Wisconsin Modeling of Electrode Contacts in Electrical Injury M Chilbert, of Wisconsin; T Prieto, A Sances, Jr., T Swiontek, J Myklebust 232 Medical College 2. Control of Epileptiform Activity with Electric Stimulation HKayyali, Case Western Reserve University; 234 D Durand IEEE EMBS 1989—xix Magnetic Field & the Current Density in the Vicinity of a Hemitoroidal Coil for Transcranial Magnetic Stimulation M Traad, University ofMiami; PP Tarjan, ED Smith, JW Levy 3. Model for 4. The Calculating the 236 Choi, University ofBritish 238 Multi-Channel Indirect Stimulation Reduces Muscle Fatigue WHappak, U University of Vienna, Austria; H Gruber, J Holle, W Mayr, Ch Schmutterer, 240 Design of a Flexible Magnetic Stimulator ASV Columbia; CA Laszlo, C Hershler 5. Windberger, U Losert, H Thoma Physiological Models Session 3.02: Session Chair: George R. Wodicka, Purdue University 1. Technology; FA Mussa-Ivaldi, 2. E Bizzi Matched Filter Theory Applied to Responses of Fly Lamina Cells Predicts Loss of Edge-Preference D 3. 242 Modeling of Multi-Joint Motor Systems J Mclntyre, Massachusetts Institute of An Orsorio, on Lowering Luminance RB 244 Pinter, University of Washington; MV Srinivasan Eye Model for Ocular Pulse Analysis WKinsner, University ofManitoba; Y 246 Yan 4. A Theoretical Model of Sound Transmission in the Thorax GR Wodicka, Massachusetts Institute of Technology; KN Stevens, DC Shannon 248 5. Estimation of Liver Analysis GBalestra, 250 Circulatory Parameters: Error Politecnico di Torino, Italy; G Belforte, G Molino 6. The Use of an "Infant Thermal Manikin" for the Assessment of Different Neonatal 252 for Premature Newborn Babies D Bolin, Institute ofNatl. Heating Equipments & I I Saiman, R Tunell Health, Sweden; Holmer, Board of Occupational Safety Session 3.03: Biochemical Kinetics Session Chair: J. B. Bassingthwaighte, University of Washington of a Model of Benzene Toxicokinetics in Mammals TJ Woodruff, University of California, Berkeley; FY Bois, JD Parker, D Auslander, S Selvin, M Smith, R Spear 254 Oxygen Exchange and Tracer Water Production EA Mates-Needham, University ofWashington; JB Bassingthwaighte 256 1. Design and Analysis 2. A Model for Blood-Tissue 3. A 4. Closed-Loop 5. Simulation of Adaptive Control of Lidocaine Serum Concentrations Based Time-Varying Compartmental Model to Assess Non-Steady State Glucose Kinetics in Hypoglycemia from Tracer Data ARuggeri, University of Padova, Italy; C Cobelli, G Toffolo, G Hetenyi Control of Multiple Drug Infusions DG Mason, University of Melbourne, Australia; IP Cade, RJ Siganporia, JS Packer Measurements TC Jannett, XX—IEEE EMBS 1989 University ofAlabama, Birmingham; JD 258 260 on Geyer Sparse 262 Session 3.04: Clinical Assessment I Session Chair: W. Clark Lambert, New Jersey Medical School 1. Impedance Estimation of Small Endotracheal Tubes with Forced Random Noise Analysis SR Quint, University of North Carolina, Chapel Hill; BR Wood, C Zhao.JMFullton 264 2. Applications of Optimization Techniques to Medicine: Houshyar, Western Michigan University; A Genaidy 267 3. Mathematical Diabetes and Screening A Modeling of the Co-Recessive Inheritance Model Linking Molecular Bayesian Epidemiologic Analysis of Cancer-Prone Cond WC Lambert, UMD-New Jersey Medical School; MW Lambert 269 Events to 4. Dynamic Analysis and Control of Cancer RR Mohler, Oregon State University; KS 272 Lee 5. LM 6. and Resuscitation Fluid Therapies in Burn Patients Roa, Universidad de Sevilla, Spain; T Gomez-Cia, A Cantero Pulmonary Capillary Dynamics Diagnosing Model Inadequacy in Human University of Southern California; Respiratory CO2 Controller F 274 276 Yang, MCK Khoo Session 3.05: Clinical Assessment II . Session Chair: G. A. 1. Dudley, NASA Experimental Evidence for Scannpath Eye Movements During Visual Imagery SA Brandt, University of California, Berkeley; LW Stark, S Hacisalihzade, J Allen, G 278 Tharp 2. Force and EMG Power GA Dudley, NASA; Spectrum in Response MR Duvoisin, to Concentric and Eccentric Exercise 280 PA Tesch 3. Magnetic and Electric Compound Action Signals in Human Sural Nerve LJ Van Briemen, Erasmus University, The Netherlands; J Meulstee, FLH Gielen 282 4. Distribution of Functional 284 Capillaries in Diaphragm Muscle WWang, University ofSouthern California; GC Sieck 5. A Pharmacokinetic Akber, Approach Simon Fraser Session 3.06: Cardiovascular Session Chair: Joel B. 1. to the Determination of University, Pulmonary Permeability SF 286 Canada Systems Myklebust, Medical College of Wisconsin A Mathematical Model of the Arterial University; E Baroreceptors TFItani, Northwestern 288 Koushanpour Systemic Autoregulation and Carotid Barorefiex R Burattini, University ofAncona, Italy; P Borgdorff, DR Gross, B Baiocco, N Westerhof 2. Interaction Between 290 3. Spectral Analysis of Heart Rate Variability: Effects of Unilateral Stellate Blockade ST Nugent, Dalhousie University, Canada; KRajagopalan, JPFinley 292 4. Simulation of Cardiovascular 294 University, China; 5. System with ECP Device K Ying, Tsinghua J Bai A Mathematical Study of the Relationship Between Cerebral Blood Volume and Intracranial Pressure Changes MUrsino, Bologna, Italy; 296 PDiGiammarco IEEE EMBS 1989—xxi 6. Multivariate Autoregressive Modeling for Analyzing Feedback-Network T Wada, School ofMedicine, Keio University, Japan in the Body 298 Session 3.07: Pulmonary Models Session Chair: J. M. Fouke, Case Western Reserve 1. Airway Exchange of Heat, Water, and Soluble Gases METsu, University of Washington; AL Babb, MP Hlastala 300 Using the Thermal Pulse Decay (TPD) Method Holmes, University of Illinois; H Arkin, MM Chen 302 Pattern Affects the Breathing 3. Tissue Blood Perfusion Measured 4. Optimal Design of Thermistor KR 1-AP-4 Probe for Surface Measurement of CBF D Wei, University; Case Western Reserve G Saidel, SC Jones l-AP-6 Effective Thermal Conductivity: Will It Permit Quantitative Hyperthermia Treatment Planning? HF Bowman, Harvard-MIT Division ofHealth Sciences MG WH Newman, SC Summit, S Chang, J Hansen, TS and Technology; Herman, 6. 299 Western Reserve Heat and Water Transport Across the Airway Wall CTsai, Case Fouke JM McFadden, Jr., GM ER Saidel, University; 2. 5. University Modelling Curley, GK Svensson the Thermoregulatory Control System Using Kernel Method AK Ahmed, 308 Faculty of Technological Studies, Kuwait Sleep Track 19: and Respiration Chair: Anne C. Comwell Session 19.01: Sleep & Session Chair: Anne C. 1. Respiration I Cornwell, Flushing Hospital/Medical Center Sudden Infant Death Syndrome (SIDS) and Sleep T 310 Hoppenbrouwers, University ofSouthern California 2. A Polysomnography High Risk Sleep Abnormality in Sudden A-Ventilatory Event (S.A.V.E.) Flushing Hospital/Medical Center; S at 313 for SIDS Infants AC Comwell, Laxminarayan 3. Sleep and Orcadian Temperature Rhythms in Winter Depression DH Avery, University ofWashington; K Dahl, M Savage, G Brengelmann, L Larson, M Vitiello, P Prinz 315 4. Sudden Infant Death Syndrome: New Results Using Statistical Data Analysis 317 Techniques JCaroff, Centre Hospitaller etUniversitaire Brest, France; Solaiman, D Alix, P Aubergier, E Girin, A Hillion 5. Heart Rate Variability in Infants Dalhousie 6. University, Canada; as a JP B Function of Sleep State ST Nugent, Decreased Vagal Tone in SIDS Victims? B Cauchemez, Hopital Lariboisiere, Paris; P Peirano, D Samson-Dolfus, N Monod, P Coumei XXii—IEEE EMBS 1989 319 Finley 321 Session 19.02: Sleep & Respiration Session Chair: Anne C. Comwell, 1. II Flushing Hospital/Medical Center Ontogeny of Respiratory Patterns in Relation to Sleep/Wake States in Fetal and Early Postnatal Life IR Moss, University of Texas Southwestern Medical Center at 323 Dallas 2. Technical Problems In Recognizing and Monitoring Infant Apnea JEYount, Oregon Health Sciences University 325 3. Perspectives on Periodic Breathing 327 4. 1/f Fluctuations in Fetal Breathing College; P in Infants JM Rates O'Brien, University of Maryland YNoguchi, Cornell University Medical 328 Cheng, G Dwyer, HH Szeto 5. A Nonparametric Statistical Approach to Breath Segmentation Wayne State University; RF Erlandson, T Roth 6. A Microprocessor-Based Sleep Apnea Ventilator KBehbehani, University of Texas at Arlington; THKang Session 19.03: TP Moyles Jr., 330 332 Sleep & Respiration III Session Chair: Anne C. Comwell, Flushing Hospital/Medical Center 1. Oxygen Desaturation Density in the At-Risk Infant RAHardoin, Brazosport Memorial Hospital, Lake Jackson, TX; JA Henslee, CP Christenson 334 2. Clinical Application of Near Infrared Spectroscopy to Neonatal Intensive Care JE 337 Brazy, University of Wisconsin-Madison; 3. Autoprotection Features of the FJ Vander-Vliet Lung Tissue During Artificial Ventilation G Boganyi, Budapest, Hungary 339 Biomedical Innovation Center, 4. Measuring Gas Exchange and Gas Mixing in Children JRBudd, University of 341 Minnesota; WJ Warwick 5. Locating Regional Lung Dysfunction by Analysis of Ventilation Distributions Carmack, Memphis State University; JR Hessler, RJ Estes 6. Recursive Estimation of Lung Mechanical Parameters in Newborn Infants During Mechanical Ventilation AR Silberberg, Chalmers University of Technology, Sweden; Additional KE Edberg, K Sandberg, 0 LJ 306 Hjalmarson Papers i-ap-i Authors' Index Keywords 343 ai Index ki IEEE EMBS 1989—XXiii