Document 6426323

Editorial
Essential
to the success
a high
scholarly
quality
of the
The
editor
manuscripts,
level
evaluation
is utterly
and all
of any journal
of
reporting
accorded
dependent
his effforts
that
of
to the
upon
would
attempts
scientific
to maintain
research
submitted
those
come
Acknowledgment
consuming
duties.
by the members
is the
manuscripts.
welcome
who
review
these
to naught
without
A. Alvares
J.C. Arcos
B.H.
Arison
ST.
N.R.
Aust
Bachur
R. Blum
K. Brendel
J.W. Bridges
R.R.
Brown
T.R.
Brown
Dingell
Domino
R. Donham
H.W.
D.E.
Dorough
Duggan
G.J. Dutton
F.S. Eberts
T.E. Eling
0. Elion
R.W.
D.A.
Estabrook
Price Evans
J.L.
P. Mazel
R.E. McMahon
H.M. Mehendale
R.E.
Holtzman
J. Hook
MG.
Horning
C.E. Inturrisi
C.C. Irving
M. Israel
Z.H.
M.O.
Lucier
Lynn
R.J. Mason
M. Marietta
DL.
Hill
E. Hodgson
Menzer
METABOLISM
of
chemicals
R. Schmid
Sporn
Stamey
R.C.
L. Sternson
W.G. Stillwell
Neal
D.W. Nebert
A. Neims
R.E. Notan
P.J. O’Brien
VT. Oliverio
S. Orrenius
J. Patel
Kaplowitz
J. Peterson
R.E. Peterson
A. Karim
Y. Kikkawa
K.A. Pittman
A. Poland
H.K.
CD.
C.C. Porter
A. Rane
Kimelberg
Klaassen
D. Koechel
GA.
Krishna
D.J.
B. La Du
G.L. Lage
J.J. Lech
R.J. Lefkowitz
RH.
E.S.
G.A.
W. Levin
R.R. Levine
Reed
M. Reidenberg
Reuning
Reynolds
S. Riegelman
D. Robard
R.J. Rubin
H.W. Ruelius
L. Lemberger
LePage
D.H.
Russell
G. Levy
E. Sanders
P.P. Saunders
J.E.
Fletcher
T.L. Loo
L.S.
J.R.
Fouts
TA.
R.R.
Loomis
454
1.0. Sipes
S. Sisenwine
M.B.
TA.
A. Kappas
N.
A..
Siemens
D.N. Silverman
Smith
Spirtes
R.A.
A.F. Junod
G.F. Kahl
W. Kalow
D. Shen
C.C.
MA.
Murphy
Shanker
Scheline
during
E.C. Schreiber
J. Selkirk
J.A. Miller
A.L. Misra
JR. Mitchell
M.R. Montgomery
T. Muther
V. Nair
Israili
James
J.D.
L. Fischer
A.B. Fisher
fate
P. ,Shore
C. Fenselau
Fenstermacher
for DRUG
R.E. Stitzel
S.J. Stohs
J. Sullivan
E. Swinyard
A.E. Takemori
T.R. Tephly
V. Thomas
R. Thompson
R.A. Van Dyke
L. Van Middlesworth
J.A. VandenHeuvel
M. Vore
D.P. Wallach
T. Walle
R.I.H.
Wang
M. Warner
E.L. Way
W. Weber
M.W. Whitehouse
F. Wiebel
G.R. Wilkinson
K.I.H.
Williams
R.T. Williams
J.T. Wilson
5K. Yang
D.W.
Yesair
D. Zakim
D.M.
Ziegler
scientific
thanks
of whom
Martin
M.R. Juchau
R.L. Juliano
J.M.
E.F.
each
Masters
Matthews
M. Chadwick
K.K. Chan
A.M. Cohen
Conney
scientists,
ofthe
many
B.S.
H.B.
D.M. Jerina
D. Jollow
R.T. Coutts
P. Dayton
F.J. Di Carlo
Lu
biological
members
with
BR.
M. Bush
I. Campbell
A.H.
the
other
N.S. Shah
K. Shiverick
D.G. Shand
G.L. Henderson
M. Heymann
A. Black
A.Y.H.
manuscripts
many
acknowledges
B. Goz
F. Greene
L.G. Hansen
J. Baron
L.Z. Benet
W. Berman
E. Bingham
K. Bischoff
or more
POSITION:
1976-1979.
following
from
G.W.
R.K.
C. Harris
Billings
of the
editor
share of the total chore is accomplished
Editorial
Advisory
Board,
but much
L. Galbery
JR. Gillette
N.C. Gillis
W.C. Govier
S. Barbonak
RE.
one
has come
The
tributions
the devoted
and conscientious
service
given by the reviewers.
This
editor
will always
be grateful
for the willing
and excellent
way in
which
reviewers
have
accepted
and discharged
these
very timeD.M. Ackerman
S. Agurell
help
community.
A large
of the
the
has
con-
reviewed
AND
the
DISperiod
Announcements
Metabolism
Drug
The
1979-80
meetings,
season
typically
invited
speaker,
Andrew
Polk,
consisting
in the
Wm.
Discussion
of this
group
of
a dinner
Delaware
H. Rorer,
Valley
Inc.,
Group
will
Fort
ical
include
and
region.
a number
a lecture
by
Information:
Washington,
Pa.
of
an
Dr.
19034.
Mechanisms
International
and
communications
mation:
Dr.
Thomas
Biological
Congress
(posters;
abstract
Robert
Snyder.
Jefferson
Effects.”
on Toxicology.
University,
Satellite
Invited
deadline,
Department
1020
symposium
lecturers
April
of
Locust
Street,
Drug
Metabolism
and
to
free
1, 1980). InforPharmacology,
Philadelphia,
Pa. 19107.
2nd
July
retariat,
international
on Toxicology
Congress
7-1 1, 1980, Brussels,
Belgium.
SdR Associated,
16 Avenue
Information:
des Abeilles,
Congress
5ccB- 1050 Brussels,
Belgium.
2nd
International
July
14-17,
Symposium
1980,
Guildford,
on
Biological
Surrey,
Reactive
England.
Intermediates
Subject:
7th
October
European
5-10,
Workshop
1980,
Zurich,
on
Switzerland.
concepts,
experimental
and clinical
methods,
new developments.
Information:
Administrative
Box
“Chem-
455
182, CH-40l3
Basic,
Switzerland.
Overview
of present
recent
trends
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#{216}SNI
AUTHOR
Acara, Margaret,
I 13
Agurell, Stig, 155
Aldridge,
A.,
Bo,
Andresen,
Andrews,
Arakawa,
Arison,
Harry
Edward,
Christina,
Ehrnebo,
S., 263
A.,
416
330
A., 335
M.,
P., 335
John W. A., 310
Fischer,
L. J., 319
L., 296
Bauer, J. E., 138
Beaubien,
A. R., 34
Becking.
George
C., 24
Ford, G. C., 226
Friel,
Patrick
B#{233}langer, Pierre
Fujii.
Toshihiko,
M.,
Fouts,
171
Bell, J. P., 81
Benet, Leslie Z., 373
Benoit, Frank, 24
Biggs,
S. R., 233
Bogentoft.
Conny,
108
Bolton, G. C., 388
Bopp, R. J., 356
Boreham,
D. R., 226
Brenner,
W., 194
Brenner-Pfaff,
Ursula, 404
Cagen, S. Z., 252
Carr, Keith, 346
Chaplin,
M. D., 81
Charpenteau,
Jean-Louis,
429
L. F., 233
Chien,M.M.,2l1
Cho, Arthur K., 65
Chu, lh, 24
Chu, N. I., 81
100
Colby, Howard
D., 52, 270
Confalone,
Pat N., 220
Coombs,
Renate
A., 132
Crabtree,
Ross E., 149
Colburn,
Wayne
A.,
Cressman,
William
Cresswell,
Peter
A.,
325
R., 393
Dahl#{246}f,
Carl G., 103
Dahlstr#{246}m, Bengt E., 108
Davis, Frank T., 360
Davis, Mary E., 425
DeGraeveJ.,
166
deLuna,
F. A.,
330
James
345
Raymond
L.,
Galtier,
Gangolli,
Gerber,
Gergely.
Pierre, 429
Sharat D., 181
N., 138
Vera, 416
Gibson,
J. E., 252
Andrew
T.,
Masahisa,
Hashimoto,
Yoshinobu,
Hitt,
Denson,
Hunt,
Donald
D., 446
252
Desaiah,
D., 28
Devereux,
Theodora
R., 70
Dhahir,
Patricia
H., 149
Ding, Teck Ling, 373
Dingell, James V., 61
Donald,
A. G., 241
Drew, Roger. 208
Duncan,
A. E. W., 330
C. Anthony,
Claes,
Jan-Erik,
155
285
L., 1
Livesey.
J. C..
Lundborg.
Lynn.
108
R. H.,
199
Per,
103
R. K., 138
Maddox,
M. L., 81
Madrid,
Visitacion
0.,
Maeda, Tadao, 435
Marquess.
Marsha
Richard
306
McHugh.
L., 270
1., 446
William
R., 1 I
K. M., 252
Suzanne
L., 40
McLennon.
McMahon,
Mechoulam,
Mehendale,
Midgley,
Migdalof,
Milburn,
Mimnaugh.
Mitchell,
Thomas
P., 204
Robert E., 76
Raphael,
155
H. M., 28, 425, 442
I.. 233
Bruce H., 325, 448
Peter, 100
Edward
G.. 208
Stephen
C., 399
Miyazaki.
Hisashi.
14, 20
Mold#{233}us,Peter, 416
Montgomery.
Mark
Muto,
435
Junko,
R.,
Nambu.
Iqbal, Zafar M., 44
lshida, Takashi,
162
Naruchi,
Nash,
Keiko,
Tatsuyuki,
14, 20
340
J. F., 356
A. El., 188, 290, 378
Nelson, Wendel
L., 351
Nordqvist,
Marianne,
155
Nowell, R. M., 215
Neims,
Jenkins,
A. B. A., 350
R., 138
Jernigan.
James
D.,
Johnson,
Peggy
B., 270
Jonen,
H. G.,
90
124
J. 0.,
Jansen,
132
Martinelli,
E., 335
Matin, S. B., 81
Maume, B., 166
Mayhew,
E., 124
14, 20, 435
A., 446
429
Lindgren,
Liu, Ann
340
Ho, 1. K., 28
Hook,
Gary E. R., 70
Claude,
McConnell,
McCormack,
Paul C., 100
Ben
404
340
Lindberg.
Mazze,
Haskins,
N. J., 226
Hassing.
J. M.. 49
Hawkins,
D. R., 233
Heider, John G., 129
Henry,
David P., 149
Hill, Donald
L., 11
Hills, Joanna
F., 448
Hinson,
Jack A., 296
Hirom,
Jyunji.
Lindsay,
Halldin,
Magnus,
155
Hama, K. M., 81
Harris, Rosalyn
A., 181
Deml, Erhard,
301
Dengler,
H. J., 145
Dent,
11
Gielen, J. E., 166
Gillette,
James R., 121, 296, 366
Gordon,
W. P., 138
Gram, Theodore
E., 208
Grech-B#{233}langer, Odeue,
171
Grey, A. A., 3 15
Griffin,D.,
138
Griffiths,
L. A., 388
Grindel,
Joseph
M., 325, 448
Gupta,
P. K., 7
Hashimoto,
Hannelore,
Kubo,
Lage, G. L., 280
Lake,BrianG.,
181
Lam, D. C. C., 285
Leal, Kenneth
W., 345
Leander,
Kurt, 155
Levy. Shlomo,
155
20
Furner,
Hasegawa,
Kreft,
Labouche,
R., 70
N.,
C., 310
Kahl, G. F., 166
Kahl. R.. 166
Kalow,W.,315
Kato, Ryuichi,
340
Kennedy.
K. A., 3 19
Kimmel,
Hazel B., I
Knowles,
John A., 40
Kolis, Stanley J.. 220
155
7
Cherie
Evelyn
132
Ferrari,
Findlay,
Fisk,
Chasseaud,
Jones,
129,
Eichelbaum,
M., 145
Eling. T. E., 420
Ende, M., 145
Epstein,
Samuel S., 44
Brian D., 360
Larry S., 296
Satoshi,
20, 435
B. H.,
Assandri,
Gwen
Dugger,
378
Alvinerie,
Michel, 429
Amos, B. A., 81
Anders,M.W.,
199
Anderson,
M. W., 420
Andersson,
Duthu,
INDEX
346
Ogilvie,
176
457
Richard
J., 383
AUTHOR
458
Oguri,
Kazuta,
Ohlsson,
Ohmiya.
Agneta.
155
Yoshio, 442
Barbara
A.. 132
Orwig,
162
Rustum,
Y. M., 124
Sasso, Gino J., 220
Schillings.
Roger T.. 40
Timbrell,
John A., 237
Tio, Cesario 0., 40
Schomerus,
T#{246}k#{233}s,
L., 81
Tom, Wai-Ming,
90
Trush, Michael
A., 208
Tuan,G.,
335
T#{252}ttenberg, K. H., 166
Schwartz,
Paalzow, Lennart K.. 108
Pakuts. A. P., 34
Palmer, R. F., 226
Pang, K. Sandy. 366
Papahadjopoulos.
D.. I24
Parker, Robert J., 100
Patel. V. 0.. 241
Patterson,
J. W.,
Pepper,
Edward
Perazzi,
A.,
81
S.. 393
335
Perez, Jorge, 383
Persson, Bengt A., 103
Pickett, R. D.. 420
Phillips,
John C., 181
Pitrolo, David A.. 52
Pohl, Lance R., 296
Pope,
Marlene
R., 270
Postma, Edward
J., 220
Powell, Mark L., 351
Radtke,
Rapport,
H. E., 194
Richard
Reg#{225}rdh,
Carl G., 103
Reinke,
L. A., 49
Remberg,
G., 145
Rice, Susan A., 260
Rickert,
M.,
Tocco,D.J.,330
145
Morton
A.,
Viateur,
220
24
Sekine, Kunio, 340
Sekine, Yutaka,
435
Shah, Nandkumar
S., 241
Shapiro,
B. H., 444
Shepard.
E. R.. 356
Sherizer,
Howard
G., 263
Shimakawa,
Keiko, 435
Shimokawa,
Noriaki,
435
Shiverick,
Kathleen
T., 290
Siddik, Zahid H., 208
Sigel. C. W., 94
Sisenwine,
Samuel F.. 1, 40
Sitar, Daniel S., 383
Smith. R. G., 138
Soliven,
Eva, 247
Sonawane,
B. R., 444
Sossi,
Nunzio,
61
Rosazza,J.P.,2I1
H., 49
Rubin, Alan, 149
Ruelius,
Hans W., 1, 40
Ruenitz,
Peter C., 204
Rumbaugh,
Richard
C., 52, 270
Unchern,
Utsui,
Surachai,
411
Yuzo, 20, 435
VandenHeuvel,
W. J. A., 330
Vanhaelen,
Maurice.
449
Vanhaelen-Fastr#{233}, Ren#{233}e,
449
Viau, Andr#{233},
24
Villeneuve,
David C., 24
Vore, Mary, 247
Vose, C. W., 226
Wagner,
Walker,
Wanders,
Heide,
301
S. J., 49
Strobl, Kristina,
366
Sullivan,
Hugh R., 76
Sum, Check Y., 65
Sweeney,
Wilson,
A. G.
Wolff,
Thomas,
Spenney,
J. G..,
215
Sternson,
Larry
A., 204
Robert
E., 270
Stohs,
E. F.,
280
Taber,
Talbot,
Douglass
Kenrick
Talcott,
Ronald
F., 346
C., 132
E., 260
14
Tanaka,
Keiichi,
Tang, B. K.. 3 15
Tannen,
Robert H., 274
Taylor.
Donald C., 393
Thithapandha,
Amnuay,
Thompson,
Thonnart,
R. M.,
Nadine,
138
449
Wang,
P. J., 81
R. W., 330
1. H., 306
Waring,
Rosemary
H.. 399
Warner,
Margaret,
188
Watson,
J. Throck,
346
Weber, Wendell
W., 194, 274
Welch, Richard
M., 310
Wilensky,
Alan J., 345
Williams,
Thomas
H., 220
D. E., 252
Ridolfo,
A. S.. 356
Ripamonti.
A., 335
Roerig. David L., 306
Roffey, Patrick, 76
Rosenberg,
Secours,
Stitzel,
L., 345
INDEX
E., 420
301
Woolley.
J. L., Jr.,
Woosley,
Raymond
Wright,
411
Richard
James
94
L., 346
M., 237
Yaffe, S. J.,444
Yamaguchi,
Hisao, 3.40
Yamaguchi.
Toshikazu.
435
Yoshida,
Aichi, 44
Yoshida,
Koji. 20, 435
Yoshimura,
Hidetoshi,
162
SUBJECT
Acebutolol-&
metabolism
Acetaminophen.
in rat
and
pharmacokinetics
2-Acetylaminofluorene,
Acetylator
polymorphism,
Acetylhydrazine
dimer metabolite,
rodent models,
effect
Acetylsalicylate
hydrolase
N-Acetyltransferase
of gastric
in baboons,
epoxidation,
genetics
P-450
demethylase.
Amitryptyline
and
Ammonium
Aryl
sulfate,
effect
hydrocarbon
specificity.
HPLC
on drug
hydroxylase,
330
determination,
181
stimulation
by polybrominated
metabolism,
Azathioprine,
in monkey,
373
genetics of N-acetylation
in, 194
Benoxaprofen,
stereochemical
inversion,
356
Benzo(ajpyrene
metabolism,
effects of diabetes,
N-demethylase
Benzylhydrazines,
in cytochrome
metabolism,
49
P-450
44
adrenal,
maturational
fractions,
changes,
188
52
and
bioavailability,
biphenyls,
81
anesthetics,
metabolism,
defluorination,
effect of isoniazid,
effect of pulmonary
edema, 383
90
multiple
solubilized,
steroid
Cytosine
arabinoside,
enzyme forms, 188
hydroxylation,
290
liposome-encapsulated.
comparative
metabolism,
Deer mouse, acetylator
polymorphism,
2’-Deoxycoformycin,
pharmacokinetics
N-Desethylation.
Desmethylimipramine.
chemical,
Diazepam,
on I-methadone
effect
113
Isolated
Ellipticine,
Endosulfan
Enterohepatic
stimulation
radioactivity.
350
glucuronide
and sulfate
metabolism
and
in perfused
lung cells,
lung.
drug
bioavailability.
416
conjugation
in. 416
310
mirex
effect,
effect
mice,
disposition.
I1
28
in, 70
search for in baboons,
in rodents,
274
metabolism,
237
260
choline
metabolism
194
and
excretion
on 2’-deoxycoformycin
cytosine
pharmacokinetics,
arabinoside,
distribution,
Lung
drug metabolism
after unilateral
pneumonectomy.
isolated cells, drug metabolism
in, 70
perfused,
amine persistence
in. 420
241
404
rat liver,
199
effects
Liposome-encapsulated
241
metabolite,
280
perfused,
disposition
in, effect
in man,
Maturational
morphine
changes.
disposition
adrenal
in, 425
drug
metabolism,
52
of ammonium
sulfate,
absorption
comparative
181
biphenyls,
Mebanazine,
and excretion,
129
biotransformation.
metabolism,
132
388
Meperidme
pharmacokinetics
and analgesia,
108
Mephenytoin
metabolism
in man, 138
6-Mercaptopurine.
pharmacokinetics
in monkey.
373
252
459
II
124
208
Mazindol
by polybrominated
296
420
metabolism
Kidney,
isolated
perfused.
ethanol
on, I 13
Leukemia,
disposition,
sulfone
124
metabolism
by Aspergilus
aiiaceus,
21 1
isomers, pharmacokinetics,
7
circulation,
pharmacokinetic
model, 100
hydrase,
hepatocytes.
isolated,
acetylation
polymorphism,
-acetylator
polymorphism
effect on acetyihydrazine
effect on drug metabolism,
by. 411
in leukemic
in isolated perfused
1,2-Dihaloethanes,
metabolism
of ethylene,
l-3-((Dimethylamino)-(m-dioxan-5-yl)methyljpyridine,
149
metabolism,
of total
persistence
274
metabolism
Dimethylnitrosamine
in isolated
Isoniazid
distribution,
346
on i-methadone
Didesmethylchlorpromazine,
Digitoxin
regulation
335
Deflazacort,
effect
in baboons.
194
of phenobarbital.
315
lminium
ion metabolism,
204
lmipramine
first-pass
kinetics, 34
metabolites,
biliary excretion,
P450
fractions,
260
N-Hydroxy-2-acetylaminofluorene.
dimer formation
during sulfation.
7-Hydroxychlorpromazine.
activation
of glucuronyltransferase.
61
N-Hydroxyphentermine.
metabolism
to nitro compound,
65
252
310
Current
Literature,
57, 1 18, 196, 243, 347, 451
Cyproheptadine.
induction
of drug metabolism
Cytochrome
340
34
disposition,
Hydrocodone,
Caffeine
pharmacokinetics
in dog. effect of inducers,
378
Canrenone,
antimineralocorticoid
effect, 103
Chlorphentermine,
persistence
in perfused
lung. 420
Chlorpromazine,
uptake in perfused
lung. 442
Choline,
renal
metabolism
and excretion,
effect
of ethanol,
Clocoumarol,
metabolism
in vitro, 449
metabolism
metabolites,
imipramine,
Fluorinated
Furosemide
Hepatocytes,
Bernard
B. Brodie Award Lecture,
121
Biphenyl
hydroxylases,
stimulation
by polybrominated
Bleomycin,
pharmacokinetics
and tissue disposition,
Codeine,
188
388
by pancreas.
hydroxylase,
fractions.
Flunisolide,
Half-lives
disposition
260
P450
(C)--Glucuronide
of feprazone.
340
Glucuronyltransferase.
activation
by 7-hydroxychlorpromazine.
61
Glutathione
transferase,
stimulation
by polybrominated
biphenyls.
252
Glutethimide,
stereochemistry
of human metabolism,
319
Guinea
pig strain differences
in adrenal drug metabolism,
270
Benzpyrene
Epoxide
kinetics,
Glucuronidation,
Baboons,
Benzphetamine
of isoniazid.
Genetics
of N-acetylation
N-Glucoside
metabolite
204
pharmacokinetics
247
biphenyls,
252
Azapetine
induction,
176
in cytochrome
human
First-pass
233
metabolism,
effect
Feprazone.
301
metabolism,
of isoniazid,
260
effect
in pregnancy.
0-de-ethylase,
stimulation
by polybrominated
biphenyls.
252
Ethylmorphine
demethylase.
adrenal,
maturational
changes.
52
4’-Ethynyl-2-fluorobiphenyl,
metabolism.
76
Extrahepatic
benzpyrene
metabolism,
effect of diabetes,
49
phenol.
metabolites,
glucuronyltransferases
reduction,
0-de-ethylase
270
cytochrome
on nitro
de-ethylase,
237
of,
and estradiol
Ethoxyresorufin
306
215
194
mucosa,
2-Aminomethyl-4-tert-butyl-6-iodo
Aminopyrine.
366
phenacetin,
296
274
circulation,
Adrenal
drug metabolism
guinea pigs, strain differences,
maturational
changes,
52
Aldrin
from
of isoniazid,
enterohepatic
Estrone
Ethanol
effect
360
man,
of formation
metabolism,
l-a-Acetylmethadol,
INDEX
of
460
SUBJECT
Metabolite
Methadone,
i-Methadone,
pharmacokinetics,
366
persistence
in perfused
lung. 420
disposition,
drug interactions,
241
Methoxsalen,
metabolism
in dogs,
Polymorphonuclear
shift in propranolol
Nitrite,
effect
on drug
Propylthiouracil,
Oxazepam.
diastereoisomeric
disposition
metabolism
351
glucuronides,
hydroxylation,
edema, effect
Radioactivity.
biological
Reduction
binding
drug
247
dosage.
345
in polymorphonuclear
metabolism
NIH shift,
of furosemide
of benzpyrene,
Solutes,
162
leukocytes.
in, 444
351
metabolism,
383
disposition
in rats, 24
bond.
oxidative
cleavage.
Pivhydrazine.
metabolism,
388
Pneum#{243}nectomy. effect on contralateral
Polybrominated
biphenyls,
stimulation
olism, 252
350
of nitro
hydrocodone.
compounds,
effect
effects
on drug
and metabolites,
of ethanol,
310
176
241
61
metabolism,
181
Spironolactone
effect on digitoxin
metabolism
280
metabolites,
antimineralocorticoid
effect, 103
Stereochemical
inversion
( R )-benoxaprofen,
356
Stereochemistry
of metabolism
of glutethimide
in humans,
319
Stereoselective
hydrolysis
of oxazepam
glucuronides,
40
Strain differences
in adrenal drug metabolism
in guinea pigs, 270
44
disposition,
half-lives,
of codeine,
SKF 525-A
effect on 1-methadone
disposition,
effects on glucuronyltransferase,
40
325
oxidative
N-dealkylation,
448
Pethidine
pharmacokinetics
and analgesia,
108
Phenacetin,
pharmacokinetics
of metabolism,
366
Phenobarbital,
N-glucoside
metabolite,
315
Phenolphthalein
enterohepatic
circulation,
100
glucuronide.
biliary excretion,
mirex effect, 28
Phenothiazine,
metabolism
in guinea
pig, 399
Phentermine,
N-hydroxylation,
65
l-Phenyl-2-(o-chlorophenyl)-2-4-(p-methoxybenzyl)nol, metabolism,
435
Photomirex,
Piperazinyl
and
rat,
Propranolol
Pulmonary
Radioimmunoassay
429
and
oxidation
Pseudohermaphrodite
Penfluridol
comparative
binding,,
263
N-Oxide
formation
from oxycodone
in rabbits,
Oxycodone.
biotransformation
in rabbits,
162
Pancreatic
and
285
group formation
from hydroxylamine.
65
reduction,
effect of ethanol,
176
p-Nitroanisole
demethylase.
effect of isoniazid,
260
1-Nitrosoadamantane,
microsomal
reduction.
171
Norgestrel,
metabolism
in female rhesus monkeys,
1
A, pharmacokinetics.
oxidation
canrenoate,
metabolites
in man, 226
Pregnancy,
estrogen
glucuronidation,
induction,
Prenazone,
human
metabolites,
340
Primidone
pharmacokinetics,
acute and chronic
Procainamide,
metabolism
in man, 346
Nitro
Ochratoxin
propylthiouracil
Potassium
220
hydroxylation,
metabolism,
leukocytes.
285
Methoxyflurane
defluorination,
isotope effect, 446
Metiamide
metabolism,
comparative,
393
Metyrapone.
N-oxidation.
166
Microbial
metabolism
of ellipticine.
21 1
Mirex effect on biliary excretion,
28
Morphine
disposition
in isolated
perfused
lung. 425
NIH
INDEX
Streptozotocin
diabetes,
effect
on
benzpyrene
metabolism,
Sulfadiazine,
metabolism
and disposition,
94
Sulfamethazine
pharmacokinetics
in baboons,
194
Sulfate conjugation,
regulation
in isolated hepatocytes,
Sulfone metabolites
of phenothiazines,
404
I-piperazinylletha-
435
Testosterone
hydroxylases,
multiplicity,
290
Tetrahydrocannabinol,
carboxylic
acid metabolites,
Tolmetin
disposition.
14
urinary
metabolites,
20
Triton X-l00, effects on glucuronyltransferase.
61
lung drug metabolism,
208
of hepatic and renal drug metabVerapamil,
metabolism
in man,
145
49
416
155