Ahrens, T., Sleeman, J.P., Schempp, ... Herrlich, P., and Simon, J.C. ...

Ahrens, T., Sleeman, J.P., Schempp, ... Herrlich, P., and Simon, J.C. ...

Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, M., Ponta, H.,
Herrlich, P., and Simon, J.C. Soluble CD44 inhibits melanoma tumor growth by
blocking cell surface CD44 binding to hyaluronic acid.
Oncogene. 20: 3399–3408, 2001.
Alaoui, J.M. A., XU.Y. Proteomic technology for biomarker profiling in cancer: an
update.
Zhejiang Univ Sci B. 7(6): 411–420, 2006.
Algire, G.H.,Chalkley, H. W. Vascular reactions of normal and malignant tissues in
vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic
transplants.
J. Natl Cancer Inst. USA 6, 73–85, 1945.
Anderson L. Candidate-based proteomics in the search for biomarkers of
cardiovascular disease.
J Physiol .563:23-60, 2005.
Artym ,V.V., Yamada, K.M., Mueller ,S.C. ECM Degradation Assays for Analyzing
Local Cell Invasion.
Methods Mol Biol. 522: 1-9, 2009.
Aruffo, A., Stamenkovi, I., Melnick, M., Underhill, C.B., Seed, B. CD 44 is the
priniple cell surface receptor for hyaluronate.
Cell.61: 1303-1313, 1990.
Asplund, T., Versnel, M. A., Laurent, T. C and Heldin, P. Human mesothelioma cells
produce factors that stimulate the production of hyaluronan by mesothelial cells and
fibroblasts.
Cancer Res. 53: 388-392, 1993.
Auvinen, P. K., Parkkinen, J.J., Johansson, R.T., Agren, U.M., Tammi, R.H.,
Eskelinen, M.J and Kosma, V.M. Expression of hyaluronan in benign and malignant
breast lesions.
Int J Cancer. 74: 477-81, 1997.
Baltimore , H. L. , Arnold, B.S,. Lawrence ,Z., Paul,M and James,D.
Molecular cell biology .3rd edition , W. H. Freeman and co , New York, 1995 .
Banerjee, S.D and Toole, B.P. Monoclonal antibody to chick embryo hyaluronanbinding protein: changes in distribution of binding protein during early brain
development.
Dev. Biol.146, 186-197, 1991.
133
Banerjee, S.D and Toole, B.P. Hyaluronan-binding protein in endothelial cell
morphogenesis.
J Cell Biol. 119: 643-652, 1992.
Banks,R.E.,Gearing,A.J.H.andHemingway,I.K.circulating ICAM-1,E-selsction and
VCAM-1 in human malignancies.
Br.J.Cancer.68: 122-124, 1993.
Bartolazzi, A., Peach, R., Aruffo, A., and Stamenkovic, I. Interaction between CD44
and hyaluronate is directly implicated in the regulation of tumor development.
J. Exp. Med.180:53–66, 1994.
Basil. C.F., Zhao, Y., Zavaglia, K., Jin, P., Panelli, M.C., Voiculescu, S.,
Mandruzzato, S., Lee, H.M., Seliger, B., Freedman, R.S., Taylor, P.R., Hu, N.,
Zanovello, P., Marincola, F.M. and Wang, E. Common cancer biomarkers.
Cancer Res. 66: 2953-2961, 2006.
Bast, R.C Jr., Lilja, H., Urban, N., Rimm, D.L., Fritsche, H., Gray, J., Veltri, R., Klee,
G., Allen, A., Kim, N., Gutman, S., Rubin, M.A and Hruszkewycz, A. Translational
crossroads for biomarkers.
Clin Cancer Res.11: 6103-6108, 2005.
Bertrand, P., Girard, N., Delpech, B., Duval, C., d’Anjou, J and Dauce, J.P
Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human
breast carcinomas: comparison between invasive and non-invasive areas.
Int. J. Cancer. 52:1–6, 1992.
Bidart, J.M., Thuillier ,F., Augereau ,C., Chalas ,J., Daver, A., Jacob ,N., Labrousse,
F., Voitot, H..Kinetics of serum tumor marker concentrations and usefulness in
clinical monitoring.
Clin. Chem. 45:1695-1707, 1999.
Bidard, F,C.,Pierga,J,Y., Vincent-Salomon,A., Poupon,M.F.A .class action against the
microenvironment: do cancer cells cooperate in metastasis?
Cancer Metastasis Rev. 27: 5-10, 2008
Bishop,J.M. Molecular themes in oncogenesis.
Cell, 64:235-248, 1991.
Bitter, T and Muir, H.M.Amodified uronic acid carbozole reaction.
Anal.Biochem.4:330-334.1962.
134
Blundell, C.D., Mahoney, D.J., Almond, A., DeAngelis, P.L., Kahmann, J.D., Teriete,
P., Pickford, A.R., Campbell, I.D and Day, A.J. The link module from ovulation
andinflammation associated protein TSG-6 changes conformation on hyaluronan
binding.
J. Biol. Chem. 278: 49261–49270, 2003.
Boregowda, R. K., Hitesh, N.A., Manjunath, S., Sunil B.K., Sunila Sunila.,
Thimmaiah K.N.,KarunaKumar, M., Bryan Toole., and Shib d Banerjee. Expression
of Hyaluronan in human tumour progression.
J Carcinog. 5: 2, 1-9,2006.
Borsig,L.,Wong,R.,Hynes,R,O.,Varki,N.M and Varki,A.Synergistic effects of L- and
P-selectin in facilitating tumor metastasis can involve non-mucin ligands and
implicate leukocytes as enhancers of metastasis.
Proc Natl Acad Sci U S A, 99:2193-2198, 2002.
Bosl,G,J., Bajorin, D,F., Sheinfeld ,J., Motzer,R.J., Chaganti,R.S. Cancer of the testis.
In: DeVita VT, Hellman S, Rosenberg SA, et al., eds.
Cancer, principles and practice of oncology. 6th ed. Philadelphia: Lippincott,
Williams & Wilkins:1491–1518, 2001.
Bot, P.T., Hoefer, I.E., Piek,J.J., Pasterkamp,G. Hyaluronic Acid: targeting immune
modulatory components of the extracellular matrix in atherosclerosis.
Curr Med Chem.15:786–791, 2008.
Bouck, N., Stellmach, V. & Hsu, S. C. How tumours become angiogenic. Adv.
Cancer Res. 69,135–174, 1996.
Bourguignon, L.Y. CD44-mediated oncogenic signaling and cytoskeleton activation
during mammary tumour progression.
J. Mammary Gland Biol, Neoplasia . 6: 287–297, 2001.
Bourguignon, L.Y., Singleton, P.A and Diedrich, F. Hyaluronan-CD44 interaction
with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1
activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to
keratinocyte adhesion and differentiation.
J Biol Chem. 279: 29654-29669, 2001.
Bradford, M. M. A rapid and sensitive method for quantitation of microgram
quantities of protein utilizing the principle of protein-dye-binding.
Anal Biochem.72:248-254,1976
135
Brat,D,J., Lillemoe,K.D., Yeo,C.J., Warfield,P.B and Hruban, R.H. Progression of
pancreatic intraductal neoplasias to infiltrating adenocarcinoma
of the pancreas.
Am J Surg Pathol. 22:163-169, 1998
Braun ,S., Pantel, K., Muller ,P., Janni ,W., Hepp F., Kentenich, C.R., Gastroph, S.,
Wischnik A, Dimpfl,T., Kindermann,G., et al. Cytokeratin-positive cells in the bone
marrow and survival of patients with stage I, II, or III breast cancer.
N Engl J Med.342(8):525–533,2000.
Calabro, A., Oken, M. M., Hascall, V. C and Masellis, A. M. Characterization of
hyaluronan synthase expression and hyaluronan synthesis in bone marrow
mesenchymal progenitor cells: predominant expression of HAS1 mRNA and upregulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma
patients.
Blood.100: 2578–2585, 2002.
Califano,J., Ahrendt ,S.A., Meininger, G., Westra ,W.H., Koch, W.M., Sydransky
D.Detection of telomerase activity in oral rinses from head and neck squamous cell
carcinoma patients.
Cancer Res.56:5720 – 5722, 1996.
Cannistra ,S.A., Abu-Jawdeh, G., Niloff, J., Strobel, T., Swanson, L., Andersen ,J and
Ottensmeier, C. CD44 variant expression is a common feature of epithelial ovarian
cancer: Lack of association with standard prognostic factors.
J Clin Oncol. 13: 1912-1921, 1995.
Carmeliet, P. Controlling the cellular brakes.
Nature 401, 657–658 ,1999.
Catalona,W.J., Richie ,J.P., Ahmann ,F.R., Hudson ,M.A., Scardino ,P.F., Flanigan
,R.C, et al. Comparison of digital rectal examination and serum prostate specific
antigen in the early detection of prostate cancer: results of a multicenter clinical trial
of 6,630 men.
J Urol.151:1283–1290, 1994.
Cavenee ,W.K., Dryja ,T.P., Phillips, R.A., Benedict,W.F., Godbout,R and Gallie,B.L
.Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.
Nature. 305:779-784,1983.
Chaly, N., Bladon ,T., Setterfield ,G., Little, J .E., Kaplan ,J .G., and Brown, D. L.
Changes in distribution of nuclear matrix antigens during the mitotic cell cycle.
The Journal of cell biology. 99:661-671, 1984.
136
Chan ,D.W., Beveridge ,R.A., Muss ,H., Fritsche ,H.A., Hortobagyi ,G., Theriault ,R.,
et al. Use of Truquant BR radioimmunoassay for early detection of breast cancer
recurrence in patients with stage II and stage III disease.
J Clin Oncol .15:2322–2328,1997.
Chen ,D.X., Schwartz ,P.E., Li ,X.G., Yang ,Z. Evaluation of CA 125 levels in
differentiating malignant from benign tumours in patients with pelvic masses.
Obstet Gynecol .72:23–27,1988.
Choy, A., Culloch,P.M.c. Induction of tumour cell shedding into effluent venous
blood breast cancer surgery.
Br J Cancer.73:79-82, 1996.
Chun, S.J., Bae, O.S., Kim, J.B. The significance of CD44 variants expression in
colorectal cancer and its regional lymph nodes.
J KoreanMed Sci. 15: 696-700,2000.
Corney DC., Flesken-Nikitin A , Choi J , Nikitin AY. Role of p53 and Rb in ovarian
cancer.
Adv Exp Med Biol. 622: 99-117, 2008.
Cristofanilli, M., Budd, G.T., Ellis, M.J, et al. circulating tumor cells, disease
progression, and survival in metastatic breast cancer.
NEnglJMed.351:781-791, 2004.
Csoka, A., Scherer,S and Stern, R. Expression analysis of six paralogous human
hyaluronidase genes clustered on chromosomes 3p21 and 7q31.
Genomics.60:351-361, 1999.
Culloch, P., Choy, A., Martin, L. Association between tumour angiogenesis and
tumour cell shedding into effluent venous blood during breast cancer surgery.
Lancet. 346: 1334-1335,1995.
Culty, M, O'mara., Underhill, T.E., Yeager, C. B and Jr, Swartz, R.P. Hyaluronan
receptor (CD44) expression and function in human peripheral blood monocytes and
alveolar macrophages.
J. Leuk. Biol.56: 605–611, 1994.
Cutforth, T and Rubin, G.M. Mutations in Hsp 83 and Cdc 37 impair signalling by the
sevenless receptor tyrosine kinase in Drosophila.
Cell. 77:1027-1036, 1994.
137
Dacai, L., Eric, P., Eugenia ,D., Kun,G., Hiroshi ,M., Tariq,H., Sanford,M., James,W.,
and Man-Sun Sy. Expression of hyaluronidase by tumour cells induces angiogenesis
in vivo.
PNAS .93: 7832-7837, 1996.
Dahl, I.M., Turesson, I., Holmberg, E., Lilja, K. Serum hyaluronan in patients with
multiple myeloma: correlation with survival and Ig concentration.
Blood. 93: 4144-4148, 1999.
Day, A. J. The structure and regulation of hyaluronan-binding proteins.
Biochem. Soc. Trans. 27, 115–121,1999.
Day, A. J and Sheehan, J. K. Hyaluronan: polysaccharide chaos to protein
organisation.
Current opinion in structural biology. 11(5):617-622, 2001.
Day, A. J and Prestwich, G. D. Hyaluronan-binding proteins, tying up the giant.
J. Biol. Chem. 277: 4585–4588, 2002.
Deb, T.B and Datta, K. Molecular cloning of human fibroblast hyaluronic acid-binding
protein confirms its identity with P-32, a protein co-purified with splicing factor SF2.
J Biol Chem. 271:2206-2212, 1996.
DeGrendele, C. H., P. Estess, and L. J. Picker & M. H. Siegelman. CD44 and its ligan
hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial
cell primary adhesion pathway.
J Exp Med. 183: 1119-1130, 1996.
Delmage, J.M., Powars, D.R., Jaynes, P.K and Allerton, S.E. The selective
suppression of immunogenicity by hyaluronic acid.
Ann. Clin. Lab. Sci. 16: 303–310, 1986.
Delpech , B., Bertrand, P. & Maingonnat, C. Immunoenzymoassay of the hyaluronic
acid-hyaluronectin interaction Application to the detection of hyaluronic acid in
serum of normal subjects and cancer patients.
Anal. Biochem.149: 555,1985.
Delpech, B., Chevallier, B., Reinhardt ,N., Julien, J.P., Duval, C., Maingonnat, C., et
al. Serum hyaluronan (hyaluronic acid) in breast cancer patients.
Int J Cancer. 15; 46: 388-390, 1990.
138
Delpech, B., Maingonnant ,C., Girard ,N., Chauzy, C., Maunoury, R., Olivier, A.,
Tayot ,J., Creissard P. Hyaluronan and hyaluronectin in the extracellular matrix of
human brain tumor stroma.
Euro J Cancer. 29A:1012-1017, 1993.
Denley,A., Kang,S., Karst,U., Vogt,P.K. Oncogenic signaling of class I PI3K
isoforms.
Oncogene. 27: 2561-2574, 2008.
Dennis, M.S., Zhang ,M., Meng,Y.G., Kadkhodayan ,M., Kirchhofer, D., Combs,D.,
et al. Albumin binding as a general strategy for improving the pharmacokinetics of
proteins.
J Biol Chem. 277:35035–35043,2002.
Devilee, P., Schuuring, E., van de Vijver, M. J and Cornelisse, C. J. Recent
developments in the molecular genetic understanding of breast cancer.
Crit. Rev. Oncogen. 5:247–270, 1994.
Dong, W.G., Sun, X.M., Yu,B.P., Luo,H.S., Yu,J.P. Role of VEGF and CD44v6 in
differentiating benign from malignant ascites.
World J Gastroenterol. 11: 2596-2600, 2003.
Duffy M. J. Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It
Clinically Useful?
Clinical Chemistry. 47:4, 624-630, 2001.
Dwivedi,C., Dixit,M., Hardy,R.E. Plasma lipid-bound sialic acid alterations in
neoplastic diseases.
Experientia;46:91–97, 1990.
Ehrmann, R. L. & Knoth, M. Choriocarcinoma. transfilter stimulation of
vasoproliferation in the hamster cheek pouch studied by light and electron
microscopy.
J. Natl Cancer Inst. 41:1329–1341, 1968.
Entwistle, J., Hall, C, L and Turely, E.A. HA receptors. Regulation of Signalling to the
Cytoskeleton.
J.Cell.Biochem. 61:569-577, 1996.
Etzioni, R., Etzioni,R., Urban ,N., Ramsey ,S., McIntosh, M., Schwartz, S., Reid, B.,
Radich, J., Anderson ,G., Hartwell, L.The case for early detection.
Nat. Rev. Cancer. 3:243-252, 2003.
139
Evanko, S.P., Wight, T.N., Intracellular localization of hyaluronan in proliferating
cells. J Histochem Cytochem. 47:1331-1342,1999.
Evanko ,S.P., Johnson, P.Y., Braun, K.R., Underhill,C.B., Dudhia ,J., Wight,T.N.
Platelet-derived growth factor stimulates the formation of versican-hyaluronan
aggregates and pericellular matrix expansion in arterial smooth muscle cells.
Arch Biochem Biophys.394:29–38, 2001.
Fedi, P., Tronick, S.R., and Aaronson, S.A. Growth factors In Cancer, R.C. Bast, D.L.
Morton, E. Frei D.W. Kufe, and R.R. Weichselbaum, eds (Baltimore, MD: Williams
and Wilkins).
Medicine, J.F. Holland, pp. 41–64,1997.
Feinberg, R.N and Beebe, D.C. Hyaluronate in vasculogenesis.
Science. 220:1177–1179, 1983.
Feinberg, A.P., Ohlsson, R and Henikoff, S. The epigenetic progenitor origin of
human cancer.
Nat.Rev.Genet. 7: 21-33, 2006.
Fenderson, B.A., Stamenkoyic and L, Aruffo., A, Localization of hyaluronan in
mouse
embryos during implantation, gastrulation and organogenesis.
Differentiation. 54: 85-98, 1993.
Ferguson, J., Ho, J-Y., Peterson, T.A and Reed, S.I. Nucleotide sequence of the yeast
cell division cycle start genes CDC 28, CDC 36, CDC 37, & CDC 39 and a structural
analysis of the predicted products.
Nucleic Acids Res. 14, 6681-6697, 1986.
Firestone, G.L and Wingoth, SD, Immunonoprecipitation of proteins.
Meth Enzymol. 182: 688-700, 1990.
Folkman ,J., Cole,P., Zimmerman,S. Tumor behavior in isolated perfused organs: in
vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal
segment.
Ann Surg. 164:491–502, 1966.
Folkman J. Tumor angiogenesis: therapeutic implications.
N Engl J Med.285:1182–1186,1971.
Folkman, J. in Cancer Medicine (eds Holland, J. F. et al.)
132–152, Decker, Ontario, Canada, 2000.
140
Forsburg,S.L and Nurse,P. Cell cycle regulation in the yeasts Saccharomyces cerevisiae
and Schizosaccharomyces-Pombe.
Annu. Rev. Cell Biol. 7:227-256,1991
Fowler JE Jr, Platoff GE, Kubrock CA, Stutzman RE. Commercial
radioimmunoassay for beta subunit of human chorionic gonadotropin: falsely positive
determinations due to elevated serum luteinizing hormone.
Cancer;49:136–139,1982.
Fox, S.B., Leek, R.D., Bliss, J., et al. Association of tumor angiogenesis with bone
marrow micrometastases in breast cancer patients.
J Natl Cancer Inst. 89: 1044-1049, 1997.
Franzmann, E. J., Erika ,P. R., Kermit,L. Carraway, K, L., Hamilton, Donald,T. Weed
and Jarrard Goodwin, W. Expression of tumour markers hyaluronic acid and
hyaluronidase (HYAL1) in head and neck tumours.
Int. J. Cancer. 106, 438–445, 2003.
Franzmann,E.J.,Reategui,E.P.,Pedroso,F.,Pernas,F.G.,Karakullukcu,Baris,M.,Carrawa
y,K. L., Hamilton,K., Singal,R., Goodwin,W.J. Soluble CD44 Is a Potential Marker
for the Early Detection of Head and Neck Cancer.
Cancer Epidemiology Biomarkers & Prevention.16:1348-1355, 2007.
Fraser, J. R. E., Kimpton, W. G., Laurent, T. C., Cahill, R. N. P., and Vakakis, N.
Uptake and degradation of hyaluronan in lymphatic tissue.
Biochem. j .256: 153-158,1988.
Fraser, J. R. E., and Laurent, T C. Turnover and metabolism of hyaluronan. In The
Biology of Hyaluronan.
Ciba Foundation Symp.143: 41-59, England ,1989.
Fraser,J.R.E.,Cahill,R.N,P., Kimpton,W.G., Laurent,T.C. Lymphatic system. In:
Comper WD, ed. Extracellular Matrix. 1. Tissue Function. Amsterdam:
Harwood Academic Publications; pp. 110–131,1996.
Fraser,J.R.E., Laurent,T.C., Laurent,U.B.Hyaluronan. Its nature, distribution,
functions and turnover.
J Intern Med 242, 27-33, 1997.
Frebourg T, Delpech B, Bercoff E et al. Serum hyaluronate in liver diseases: Study by
enzymoimmunological assay.
Hepatology. 6:392-395, 1986.
141
Friedrichs,K., Franke,F., Lisboa, B.W., Kugler, G., Gille ,I., Terpe, H.J., Hoizel
,F.,Maass, H and Gunthert ,U. CD44 isoforms correlate with cellular differentiation
but not with prognosis in human breast cancer.
Cancer Res. 55:5424-5433, 1995.
Fries,H., Elsasser,H.P., Mahlbacher,V., Neumann,K., Kern,H.F. Localization of
hyaluronate (HA) in primary tumors and nude mouse xenografts of human pancreatic
carcinomas using abiotinylated HA-binding protein.
Virchows Archiv. 424: 7-12, 1994.
Fukumura, D.,et al. Tumor induction of VEGF promoter activity in stromal cells.
Cell 94, 715–725,1998.
Gadducci, A., Ferdeghini ,M., Cosio,S., Annicchiarico, C., Fanucchi ,A., Prontera,C.,
Bianchi ,R., Genazzani ,A.R.The serum assay of soluble CD44 standard (sCD44-st),
CD44 splice variant 5 (sCD44-v5), and CD44 splice variant 6 (sCD44-v6) in patients
with cervical cancer.
Anticancer Res. Jan-Feb18(1B):537-539, 1998.
Gakunga, P, Frost G, Shuster S, Cunha G, Formby B, Stern R. Hyaluronan is a
prerequisite for ductal branching morphogenesis.
J. Development. 124:3987-3997, 1997.
Gerber, M,R., Farrell, A., Deshaies, R.J., Herskowitz, I and Morgan, D.O. Cdc37 is
required for association of the protein kinase Cdc28 with Gl and mitotic cyclins.
Proc. Natl. Acad. Sci. 92: 4651-4655, 1995.
Ghatak., S, Misra., S, Toole., B.P. Hyaluronan constitutively regulates ErbB2
phosphorylation and signalling complex formation in carcinoma cells.
J Biol Chem. 280:8875-8883, 2005.
Ghosh, A., Wang, X., Klein, E., Heston, W.D. Novel role of prostate-specific
membrane antigen in suppressing prostate cancer invasiveness.
Cancer Res. 65:727-731, 2005.
Gion ,M., Mione ,R., Leon ,A.E., Dittadi ,R. Comparison of the diagnostic accuracy
of CA27.29 and CA15.3 in primary breast cancer.
Clin Chem.45:630–637, 1999.
Gmachl,M., Sagan, S., Ketter,S., Kreil,G. The human sperm protein PH-20 has
hyaluronidase activity.
FEBS Lett. Dec 28;336(3):545-548, 1993.
142
Goebeler, M., Kaufmann, D., Brocker, E.B and Klein ,C.E. Migration of highly
aggressive melanoma cells on hyaluronic acid is associated with functional changes,
increased turnover and shedding of CD44 receptors.
J. Cell. Sci. 109:1957 - 1964. 1996.
Goi,T., Yamaguchi,A., Seki K, Nakagawara ,G., Urano,T., Shiku,H., Furukawa,K.
Soluble protein encoded by CD44 variant exons 8-10 in the serum of patients with
colorectal cancer. Br J Surg.84: 1452-1453,1997.
Goldman, E. The growth of malignant disease in man and the lower animals with
special reference to the vascular system.
Lancet 2, 1236–1240, 1907.
Gordon, L.M., Curtain,C.C., McCloyn,V., Kirkpatrick,A., Mobley,P.W., etal. The
amino-terminal peptide of HIV-1 gp41 interacts with human serum albumin.
AIDS Res Hum Retroviruses. 9:1145–1156,1993.
Goyette, M. C., Cho, K., Fasching, C. L., Levy, D. B., Kinzler, K. W and Paraskeva,
C. Progression of colorectal cancer is associated with multiple tumor suppressor gene
defects but inhibition of tumorigenicity is accomplished by correction of any single
defect via chromosome transfer.
Mol. Cell. Biol. 12: 1387–1395, 1992
Grammatikakis, N., Grammatikakis, A., Yoneda, M., Yu, Q., Banerjee, S.D and Toole,
B.P. A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell
cycle control protein, Cdc37.
J Biol Chem. 270:16198-16205, 1995.
Granger, H.J., Laine, G.A., Barnes, G.E and Lewis, R.E. Dynamics and control of
transmicrovascular fluid exchange.
In: Staub, N.C., Taylor, A.E. (Eds.) Edema. Raven Press, New York, pp. 189–228,
1984.
Green, S.J., Tarone, G and Underhil, B l. Aggregation of macrophages and fibroblasts
is inhibited by a monoclonal antibody to the hyaluronate receptor.
Journal Cell Science. 89:145-156, 1988.
Greenblatt, M. & Shubik, P. Tumor angiogenesis: transfilter diffusion studies in the
hamster by the transparant chamber technique.
J. Natl Cancer Inst. 41, 111–124 ,1968.
Greg l. Perkins, m.d., evan d. Slater, m.d., georganne k. Sanders, m.d., and john g.
Prichard, m.d., Ventura County Medical Center, Ventura, California.
Am Fam Physician. Sep 15;68(6):1075-1082, 2003.
143
Gronbaek,K and Guldberg,P. Acquired mutations--basic cancer biology.
Ugeskr Laeger. 168: 2335-2338, 2006.
Gronborg, M.., Kristiansen, T. Z., Iwahori, A.,Chang, R.,Reddy, R., Sato, N., Molina,
H., Jensen, O. N., Hruban, R. H., Goggins, M. G., Maitra, A., Pandey, A. Biomarker
discovery from pancreatic cancer secretome using a differential proteomic approach
Mol. Cell. Proteomics. 5 (1): 157– 171, 2006.
Gullino, P. M. Angiogenesis and oncogenesis.
J. Natl Cancer Inst. 61: 639–643 ,1978.
Guo, Y.J.,Liu,G.,Wang,X.et al., Potential use of soluble CD44 in serum as indicator
of tumour burden and metastasis in patients with gastric or colon cancer.
Cancer Res.54:422-426, 1994.
Guo, Y., Ma, J., Wang, J., Che, X., Narula, J., Bigby, M., Wu, M., and Sy, M.S.
Inhibition of human melanoma growth and metastasis in vivo by anti-CD44
monoclonal antibody.
Cancer Res., 54, 1561–1565, 1994.
Gunthert ,U.,Hofman, R., Ruby, W., Ruber,S.,Zoller , M., Haussman ,I., matzku,
S.,Weszel ,A., Ponta, H and Herrlich ,P. A new variant of glycoprotein CD44 confers
metastatics potential to rat carcinoma cells.
Cell .65:13-24, 1991.
Hall, C.L., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L.A., Wang, C,
Curpen, G.D., Savani, R.C., Greenberg, A.H and Turley, E.A. Overexpression of the
hyalurnan receptor RHAMM is transforming and is also required for H-ras
transformation.
Cell. 82:19-28, 1995.
Hall, M and Peters, G. Genetic alterations of cyclins, cyclin-dependent kinase and cdk
inhibitors in human cancer.
Adv. Cancer Res. 68: 67-108, 1996.
Hallgren, R., Engstrom- -Lauren, A. & Nisbeth, A.Circulating hyaluronate. A
potential marker of altered metabolism of the connective tissue in uremia.
Nephron.46:150, 1987.
Hanahan, D. & Weinberg, R. A. The hallmarks of cancer.
Cell 100, 57–70, 2000.
144
Harada,N., Mizoi,T., Kinouchi,M., Hoshi,K., Ishii,S., Sasaki ,I., Matsuno, S.
Introduction of antisense CD44s CDNA down-regulates expression of overall CD44
isoforms and inhibits tumour growth and metastasis in highly metastatic colon
carcinoma cells.
Int J Cancer.91: 67-75, 2001.
Hardwick, C., Hoare, K., Owens, R., Hohn, H. P., Hook, M., Moore, D., Cripps, V.,
Austen, L., Nance, D. M and Turley, E. A. Molecular cloning of a novel hyaluronan
receptor that mediates tumour cell motility.
J. Cell Biol. 117: 1343-1350, 1992.
Hautmann, S, H., Schroeder, G, L., Civantos, F., Duncan, R.C., Gnann, R., Friedrich,
M.G., et al.Hyaluronic acid and hyaluronidase. 2 new bladder carcinoma markers.
Urologe A. 40: 121-126, 2001.
Heng,H.H.Q., Spyropoulos,B., Moens ,P. FISH technology in chromosome and
genome research.
BioEssays. 19:75-84, 1997.
Heng,H.H.Q, Krawetz,S.A., Lu ,W., Bremer, S., Liu, G., Ye, C.J. Re-defining the
chromatin loop domain.
Cytogent Cell Genet.93:155-161, 2001.
Higashikawa, K., Yokozaki, H., Ue, T., Taniyama, K., Ishikawa, T., Tarin, D and
Tahara, E. Evaluation of CD44 transcription variants in human digestive tract
carcinomas and normal tissues.
Int J Cancer. 66: 11–17, 1996.
Hiltunen, E.L., Anttila, M., Kultti, A., Ropponen, K., Penttinen,J., Yliskoski,M.,etal.
Elevated hyaluronan concentration without hyaluronidase activation in malignant
epithelial ovarian tumors.
Cancer Res. 62: 6410-6413, 2002.
Hiscock, D.R., Yanagishita, M and Hascall, V.C. Nuclear localization of
glycosaminoglycans in rat ovarian granulosa cells.
J. Biol. Chem. 269:4539-4546,1994.
Hobarth, K., Marier, U and Marberger., M. Tropical chemoprophylaxis of bladder
cancer by mitomycin C and hyaluronidase.
Eur. Urol. 21:206-210,1992.
Hoon, D.S., Bostick, P., Kuo,C., et al. Molecular markers in blood as surrogate
prognostic indicators of melanoma recurrence.
Cancer Res.60:2253 -2257, 2000.
145
Hopwood, J., Dorfman ,A. Glycosaminoglycan synthesis by Wilms' tumor.
Pediatr Res. 12(1):52-56, 1978.
Horai, T., Nakamura, N., Tateishi, R and Hattori, S. Glycosaminoglycans in human
lung cancer.
Cancer (Phila.). 48:2016-2021, 1981.
Hu,Y.C., Sidransky, D., Ahrendt, S.A. Molecular detection approaches for smoking
associated tumors.
Oncogene.21:7289 – 7297, 2002.
Huang, L., Grammatikakis, N., Yoneda, M., Banerjee, S.D and Toole, B.P. Molecular
characterization of a novel intracellular hyaluronan-binding protein.
J Biol Chem. 275:29829-29839, 2000.
Hugosson, J., Aus,G., Lilja,H., Lodding,P., Pihl ,C.G., Pileblad ,E. Prostate specific
antigen based biennial screening is sufficient to detect almost all prostate cancers
while still curable.
J. Urol. 169:1720-1723, 2003.
Hyodo, L., Jinno, K., Tanimizu, M. et al. Detection of circulating ICAM-1 in
hepatocellular carcinoma.
Int.J.Cancer.55:775-779,1993.
Ibora, F., Cook, P.R., Jackson, D.A. Applying microscopy to the analysis of nuclear
structure and function.
Methods.29:131-141 2003.
Ide, A. G., Baker, N. H. & Warren, S. L. Vascularization of the Brown-Pearce rabbit
epithelioma transplant as seen in the transparent ear chamber.
Am. J. Radiol. 42: 891–899, 1939.
Iida, N and Bourguignon, L.Y. Coexpression of CD44 variant (vl0/exl4) and CD44S
in human mammary epithelial cells promotes tumorigenesis.
J Cell Physiol. 171:152-160,1997.
Inger, S., and Laurent, T.C. Concentration of Hyaluronan in the Serum of Untreated
Cancer Patients with Special Reference to Patients with Mesothelioma.
Cancer. 62:326-330, 1988.
Iozzo, R and Muller-Glauser, W. Neoplastic modulation of extracellular matrix:
proteoglycan changes in the rabbit mesentery induced by V2 carcinoma cells
Cancer Res. 45: 5677-5687, 1985.
146
Iozzo, R.V. Matrix proteoglycans: from molecular design to cellular function.
Annu Rev Biochem. 67:609-652, 1998.
Ishihara, M., Fedarko, N.S and Conrad, H.E. Transport of heparan sulfate in to the
nuclei of hepatocytes.
J. Biol. Chem. 261: 13575-13580, 1986.
Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M.,Shinomura,
T., Hamaguchi, M.,Yoshida,Y., Ohnuki,Y., Miyauchi, S., Spicer, McDonald A. P, J.
A and Kimata, K.. Three isoforms of mammalian hyaluronan synthases have distinct
enzymatic properties.
J. Biol. Chem. 274:25085 – 25092, 1999.
Itano,N.Simple primary structure, complex turnover regulation and multiple roles of
hyaluronan.
J Biochem. 144(2):131-137, 2008.
Jacobs, I and Bast, R.C.J. The CA 125 tumour-associated antigen.
Hum Reprod..4(1):1-12,1989.
Jakson, A.M., Alexandrov, A.B., Gribben, S.C.et al.Expression and shedding of
ICAM-1 in bladder cancer and its immunotherapy.
Int.J.Cancer.55:921-925, 1993.
Jauch,K.W., Heiss,M.M., Gruetzner,U.,et al. Prognostic significance of bone marrow
micrometastases in patients with gastric cancer.
J Clin Oncol. 14: 1810-1817, 1996.
Johnson, P.J. The role of serum alpha-fetoprotein estimation in the diagnosis and
management of hepatocellular carcinoma.
Clin Liver Dis.5:145–159, 2001.
Jortani, S.A., Prabhu, S.D., Valdes (Jr.), R. Strategies for developing biomarkers of
heart failure.
Clin. Chem. 50:265-278,2004.
Jung, C.S., Foerch ,C., Schänzer, A., Heck, A.,Plate, K. H., Seifert ,V., Steinmetz, H.,
Raabe ,A and Sitzer, M .Serum GFAP is a diagnostic marker for glioblastoma
multiforme
Brain. 130: 3336-3341, 2007.
147
Karjalainen, J. M. Reduced level of CD44 and hyaluronan associated with
unfavorable prognosis in clinical stage I cutaneous melanoma.
Am. J. Pathol. 157: 957–965, 2000.
Karvinen, S., Kosma, V. M., Tammi, M. I and Tammi, R. Hyaluronan, CD44 and
versican in epidermal keratinocyte tumours.
Br. J. Dermatol. 148: 86–94, 2003.
Kaufmann, M., Heider, K.H., Sinn, H.P., Von Minckwitz ,G., Ponta ,H and Herrlich
,P. CD44 variant exon epitopes in primary breast cancer and length of survival.
Lancet.345: 615-619, 1995.
Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P and Stamenkovic, I. Selective
suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene
driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and
impairs keratinocyte proliferation.
Genes Dev. 11: 996–1007, 1997.
Kerbel, R. S. Tumor angiogenesis: past, present and the near future.
Carcinogenesis. 21: 505–515, 2000.
Kim, S.Y., Toretsky,J.A., Scher,D., Helman,L.J. The role of IGF-1R in pediatric
malignancies.
Oncologist. 14: 83-91, 2009.
Kimata, K., Honma, Y., Okayama, M., Oguri, K., Hozumi, M and Suzuki, S.,
Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants
with high metastatic potential.
Cancer Res.43: 1347–1354, 1983.
Kinzler, K.W., and Vogelstein, B.Lessons from hereditary
colorectal cancer. Cell 87: 159–170,1996.
Kinzler, K. W. and Vogelstein, B. Landscaping the cancer terrain.
Science .280:1036–1037, 1998.
Knudson, C.B and Knudson, W. Hyaluronan binding proteins in development, tissue
homeostasis and disease,
FASEB. J.7:1233-1241, 1993.
Knudson,W., Biswas,C. and Toole, B. P. Interactions between human tumour cells
and fibroblasts stimulate hyaluronate synthesis.
Proc. Natl Acad. Sci. USA, 81:6767–6771, 1984.
148
Knudson, W., Biswas, C, Li, X, Q., Nemec, R, E and Toole, B.P. The role and
regulation of Tumor-associated hyaluronan.
Ciba Found. Symp. 143: 150-159, 1989.
Knudson, W, Tumor-associated hyaluronan. Providing an extracellular matrix that
facilitates invasion
Am J Pathol.148:1721-1726, 1996.
Kojima, J., Nakamura, N., Kanatani, M., Omori,K. The glycosaminoglycans in human
hepatic.
Cancer. Cancer Res.35: 542-547, 1975.
Koomen, J.M., Li ,D., Xiao, L.C., Liu ,T.C., Coombes ,K.R., Abbruzzese, J.,
Kobayashi, R.Direct tandem mass spectrometry reveals limitations in protein profiling
experiments for plasma biomarker discovery.
J. Proteome Res. 4:972-981, 2005.
Koretz, K., Moller, P., Lehnert, T., Hinz, U., Otto, H.F and Herfarth, C. Effect of
CD44v6 on survival in colorectal carcinoma.
Lancet. 345: 327-328, 1995.
Koyama,H., Hibi,T., Isogai, Z., et al. Hyperproduction of hyaluronan in neu-induced
mammary tumor accelerates angiogenesis through stromal cell recruitment: possible
involvement of versican/PG-M.
Am J Pathol. 170:1086–1099,2007
Laemmli,U.K. Cleavage of structural proteins during the assembly of the head of
bacteriophage T4.
Nature. 227: 680-685, 1970.
Lai,P.H., Chang ,Y., Chen,S.C, Wang, C.C., Liang ,H.C., Chang ,W.C., Sung ,H.W.
Acellular biological tissues containing inherent glycosaminoglycans for loading basic
fibroblast growth factor promote angiogenesis and tissue regeneration. Tissue Eng.
12:2499–2508,2006.
Lambeck, A .J. A., Crijns, A. P.G., Leffers ,N,.Wim,Sluiter,.Klaske, A,. ten
Hoor,Mike Braid.,Ate, G.J van der, Zee., T Daemen, Hans W. Nijman, and W.Martin
Kast. Serum Cytokine Profiling as a Diagnostic and Prognostic Tool in Ovarian
Cancer: A Potential Role for Interleukin 7.
Clinical cancer Res. 13: 2385-2391,2007.
Laurent,U.B.G., Laurent, T.C. On the origin of hyaluronate in blood.
Biochem Int ,2: 195–9, 1981.
149
Laurent, E.A., Loof L, Nyberg, A., Schroder T. Increased serum levels of hyaluronate
in liver disease.
Hepatology. 5:638-642, 1985.
Laurent, A., Laurent, U.B.G., Lilja, K. & Laurent, C.T. Concentrations of sodium
hyaluronate in serum.
Scand. J. Clin. Lab. Invest. 45: 497.1985.
Laurent, E.A., Hallgren R. Circulating hyaluronate in rheumatoid arthritis:
Relationship to inflammatory activity and the effect of corticosteroid therapy.
Ann Rheum .44:83-88, 1985.
Laurent, T. C., and Fraser, J. R. E. The properties and turnover of hyaluronan. In
Functions of Proteoglycans,
Ciba Foundation Symp.124: 9-29,England, 1986.
Laurent, T.C., Dahl, I.M.S., Dahl, L,B et al. The catabolic fate of hyaluronic acid.
Connect Tissue.
Res. 15:33-41, 1986.
Laurent, T.C and Fraser, J.R.E.Catabolism of hyaluronan. In Degradation of
BioactiveSubstances.
Physiology and Pathophysiology.249-265, CRC Press, Boca Raton, Florida, 1991.
Laurent, T.C and Fraser, J.R. Hyaluronan.
FASEB J. 6: 2397–2404,1992.
Lee, T.H., Wisniewski, H-G and Vilcek, J. A novel secretory tumor necrosis factorinducible protein (TSG-6) is a member of the family of hyaluronate binding proteins,
closely, related to the adhesion receptor CD44.
J Cell Biol. 116: 545-557, 1992.
Lesley, J., Hascall, V.C., Tammi, M., and Hyman, R.Hyaluronan binding by cell
surface CD44.
J. Biol. Chem. 275: 26967–26975, 2000.
Leu, A. J., Berk, D. A., Lymboussaki, A., Alitalo, K. & Jain, R. K. Absence of
functional lymphatics within a murine sarcoma: a molecular and functional
evaluation.
Cancer Res. 60, 4324–4327, 2000.
Lindemann, F., Schlimok, G., Dirschedl,P., et al. Prognostic significance of
micrometastatic tumour cells in bone marrow of colorectal cancer patients.
Lancet. 340: 685-689. 1992.
150
Liotta, L.A., Saidel, M.G., Kleinerman, J. The significance of hematogenous tumorcell clumps in the metastatic process.
Cancer Res. 36: 889-894. 1976.
Liotta, L.A., Petricoin ,E.F. Clinical proteomics: written in blood.
Nature.425:905,2003.
Liotta, L.A., Petricoin ,E.F. Serum peptidome for cancer detection:spinning biologic
trash into diagnostic gold
J. Clin. Invest. 116:26–30, 2006.
Lipponen ,P., Aaltomaa, S., Tammi ,R., Tammi ,M., Ågren ,U and Kosma,V.M.High
stromal hyaluronan level is associated with poor differentiation and metastasis in
prostate cancer.
Eur J Cancer. 37:849-856, 2001.
Liu,P.F., Wu,M.C., Cheng,H., Qian,G.X., Fu ,J.L. Clinical significance of expression
of metastasisa2associated splice variants of CD44 mRNA in early primary liver
cancer.
China Natl J New Gastroenterol. 2: 112-114, 1996.
Liu, N., Lapcevich, R.K., Underhill, C.B., Han, Z., Gao, F., Swartz, G., Plum, S.M.,
Zhang, L., and Gree, S.J. Metastatin: a hyaluronan-binding complex from cartilage
that inhibits tumor growth.
Cancer Res. 61, 1022–1028,2001.
Lokeshwar, V.B., Obek, C., Soloway, M.S and Block, N.L. Tumor-associated
hyaluronicacid: a new sensitive and specific urine marker for bladder cancer.
Cancer Res. 57: 773-779, 1997.
Lokeshwar,V.B., Soloway,M.S and Block, N.L. Secretion of bladder tumor-derived
hyaluronidase activity by invasive bladder tumor cells.
Cancer. Res. 131: 21-27,1998.
Lokeshwar, V.B, Obec, C., Phom, H.T., Wei, D., Young, M.J., Duncan R.C.,
Soloway, M.S and Block, N.L. Urinary hyaluronic acid and hyaluronidase: markers
for bladder cancer detection and evaluation of grade.
J. Urol.163, 348-356, 2000.
Lokeshwar,V.B.,Schroeder,G.L.,Selzer,M.G.,Hautmann,S.H.,Posey,J.T.,Duncan,R.C.,
Watson, R., Rose, L., Markowitz,S and Soloway,M.S. Bladder tumour markers for
monitoring recurrence and screening comparison of hyaluronic acidhyaluronidase and
BTA-Stat tests.
Cancer, 95, 61–72, 2002.
151
Lou, X., Xiao, T.,Zhao, K., Wang., Zheng, H., Lin, D.; Lu, Y., Gao, Y., Cheng, S.,
Liu, S., Xu, N. Cathepsin D is secreted from M-BE cells: its potential role as a
biomarker of lung cancer
J. Proteome Res, 6 (3): 1083– 1092, 2007.
Lowenthal,M. S.,Mehta, A.I., Frogale, K., Russell, W., Bandle, Robyn,P,. Araujo,
BrianL.Hood., Timothy, D. Veenstra.,Thomas P. Conrads., Paul Goldsmith., David
Fishman,4 Emanuel F. Petricoin III,and Lance A. Liotta .Analysis of albumin
associated peptides and proteins from ovarian cancer patients.
Clinical Chemistry.51 :10, 1933-1945,2005.
Lucas, M.G., Green, A.M and Telen, M.J. Characterization of serum In (Lu)-related
antigen: identification of a serum protein related to erythrocyte p80.
Blood .73: 596–600, 1989.
Ludwig, J.A., Weinstein,J.N. Biomarkers in cancer staging, prognosis and treatment
selection.
Nature Reviews Cancer.5 (11):845–856, 2005.
Margolis, R.K., Crockett, C.P., Kiang, W.L and Margolis, R.U.
Biochem. Biophys Acta. 451: 465-469, 1976.
Matsumura,K.,Kawanishi,I.,Fujii,S. et al. Altered expression of E-cadherin in gastric
cancer tissues and carcinomatous fluid.
Br.J.Cancer.66:1122-1130,1992.
Mayer, B., Jauch ,K.W., Gunthert ,U., Figdor, C.G, Schildberg, F.W., Funke ,I and
Johnson,J.P. De-novo expression of CD44 and survival in gastric cancer.
Lancet.342:1019-1022, 1993.
Mayer,S., zur, H.A., Watermann, D.O., Stamm ,S., Jäger ,M., Gitsch, G., Stickeler, E.
Increased soluble CD44 concentrations are associated with larger tumor size and
lymph node metastasis in breast cancer patients.
J Cancer Res Clin Oncol. Nov;134(11):1229-1235. Epub Apr 26, 2008.
McBride, W.H and Bard, J.B. Hyaluronidase-sensitive halos around adherent cells.
Their role in blocking lymphocyte-mediated cytolysis.
J. Exp. Med. 149, 507–515, 1979.
McClay, DR., and Ettensohn, C.A. Cell adhesion in morphogenesis.
Annu. Rev Cell Biol, 3, 319-345. 1987.
152
McCourt, P.A.G., Ek, B., Forsberg, N and Gustafson, S. Intercellular adhesion molecule-I is
a cell surface receptor for hyaluronan.
J Biol Chem. 269, 30081-30084, 1994.
Mehta, P., Ploutz-Snyder., Robert, Nandi., Jyotirmoy, Rawlins., Sekou,R., Sanderson,
Schuyler, O., Levine, Robert,A. Diagnostic Accuracy of Serum Hyaluronic Acid,
FIBRO Spect II, and YKL-40 for Discriminating Fibrosis Stages in Chronic Hepatitis C
Am J Gastroentology. 103:928-936, 2008.
Meyer, K and palmer J.W. The polysaccharide of the viterous humor.
J Bio Chem.107: 629-634, 1934.
Miyake,K., Underhill, C.B., Lesley, J and Kincade,P.W .Hyaluronate can function as
a cell adhesion molecule and CD44 participates in hyaluronate recognition.
J Exp Med .172: 69-75, 1990.
Mohapathra, S., Yang, X., Wright, J.A., Turley, E.A and Greenberg, A.H. Soluble hyaluronan
receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclinBl expression.
J Exp Med. 183:1663-1668, 1996.
Mulder,J.W.R., Kruyt, P.M., Sewnath, M., Oosting, J., Seldenrijk ,C.A., Weidema,
W.F.,Offerhaus, G.J.A and Pals, S.T. Colorectal cancer prognosis and expression of
exon-v6-containing CD44 proteins.
Lancet. 344: 1470-1472, 1994.
Muller, A., Homey, B., Soto, H., Ge, N., Catron, D and Buchanan, M.E. Involvement
of chemokine receptors in breast cancer metastasis.
Nature. 410:50-56, 2001.
Nikitenko, L.L. Vascular endothelium in cancer.
Cell Tissue Res. 335: 223-240, 2009.
Noble, P.W., McKee, C.M., Cowman, M and Shin, H.S. Hyaluronan fragments
activate an NF-kappa B/I-kappa B alpha auto-regulatory loop in murine macrophages.
J. Exp. Med.183: 2373–2378, 1996.
Noble,P.W. Hyaluronan and its catabolic products in tissue injury and repair.
Matrix Biol.; 21:25–29, 2002.
Omenn,G.S.,States,D.J.,Adamski,M.,Blackwell,T.W.,Menon,R.,Hermjako,b.H.,Apwe
iler,R., Haab,B.B., Simpson ,R.J., Eddes ,J.S, et al.. Overview of the HUPO Plasma
Proteome Project: results from the pilot phase with 35 collaborating laboratories and
multipleanalytical groups, generating a core dataset of 3020 proteins and a publiclyavailable database.
153
Proteomics. 5:3226-3245, 2005.
Paiva,P.,Van, Damme M.P., Tellbach, M., Jones, R.L., Jobling ,T., Salamonsen, L.A.
Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate
a role for hyaluronan in the progression of endometrial cancer.
Gynecol Oncol.98:193–202. 2005.
Pantel, K., Cote, R.J., Fodstad,O. Detection and clinical importance of
micrometastatic disease. JNatl CancerInst.91:1113-1124, 1999.
Peter, Carmeliet & Rakesh ,K. Jain, review article Angiogenesis in cancer and other
diseases.
Nature .407:249-257 doi:10.1038/35025220,2000.
Peterson, R.M., Yu, Q., Stamenkovic, I., and Toole, B.P. Perturbation of hyaluronan
interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in
ascites.
Am. J. Pathol., 156, 2159–2167, 2000.
Pia, N., Pia, H., Timo, S., Jani, L., Ritva, H., Ulf-Hakan, S., Taina, P and Tuula, S.
Endostatin inhibits human tongue carcinoma cell invasion and intravasation and
blocks the activation of MMP-2, MMP-9, MMP-13.
J. Biol. Chem. 278: 22404 –22411, 2003
Pirinen,R.T.,Tammi,R.H.,Tammi,M.I.,Paakko,P.K.,Parkkinen,J.J.,Agren,U.M.Expres
sion of hyaluronan in normal and dysplastic bronchial epithelium and in squamouscell carcinoma of the lung.
Int J Cancer (Ped Oncol). 79:251-255, 1998.
Pirinen,R.T., Hirvikoski, P., Johansson, R.T., Hollmen ,S., Kosma ,V.M. Reduced
expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high
cell proliferative activity and poor differentiation in non-small cell lung cancer.
J Clin Pathol. 54:391-395, 2001.
Ponder, B .Cancer Gene losses in human tumours.
Nature, 335:400-402,1988.
Ponta, H., Sherman, L. and Herrlich, P. CD44: from adhesion molecules to signaling
regulators. Nature Rev.
Mol. Cell Biol. 4:33–45, 2003.
Posey, J.T., Soloway, M.S and Ekici ,S. Evaluation of the prognostic potential of
hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer.
Cancer Res. 63: 2638-2644, 2003.
154
Qinghua Shi and Randall W. King,Chromosome nondisjunction yields tetraploid
rather than aneuploid cells in human cell lines.
Nature.doi: Editor's Summary Cancer and cell division 10.1038/03958 ,2005.
Ramanujan, S., Koenig, G. C., Padera, T. P., Stoll, B. R. & Jain, R. K. Local
imbalance of proangiogenicand antiangiogenic factors: a potential mechanism of focal
necrosis and dormancy in tumours.
CancerRes. 60:1442–1448 ,2000.
Reed, S.I. The role of p34 kinases in the Gl to S-phase transition.
Annu. Rev. Cell Biol. 8: 529-561, 1992.
Rhodes, J. M. Usefulness of novel tumour markers
Annals of Oncology. 10 suppl 4: S 118-S12117,1999.
Ripellino, J.A., Margolis, R.U and Margolis, R.K. Immunoelectron microscopic
localization of hyaluronic acid-binding region and link protein epitopes in brain.
J. Cell Biol. 108:1899-1907, 1989.
Richter, R., Schulz-Knappe,P., Schrader,M., Ständker,L., Jürgens, M., Tammen, H.,
Forssmann ,W.G.Composition of the peptide fraction in human blood plasma:
database of circulating human peptides.
J. Chromatogr. B Biomed. Sci. Appl. 726:25-35, 1999.
Ristamaki, R., Joelsuu, H., Salm, M. et al. Serum CD44 in malignant lymphoma: an
association with treatment response.
Blood.84:238-243,1994.
Ripellino J.A., Margolis, R.U and Margolis, R.K. Immunoelectron microscopic
localization of hyaluronic acid-binding region and link protein epitopes in brain.
J Cell Biol. 108:1899-1907, 1989.
Roboz, J., Greaves, J., Silides ,D., Chahinian, A.P., Holland, J.F. Hyaluronic acid
content of effusions as a diagnostic aid for malignant mesothelioma.
Cancer Res. 45: 1850-1854, 1985.
Rooney,P., Kumar, S., Ponting ,J., Wang, M. The role of hyaluronan in tumour
neovascularization.
Int J Cancer.60:632–636, 1995.
Ropponen, K., Tammi, M., Parkkinen, J., Eskelinen, M., Tammi, R, Lipponen P,
Agren U, Alhava, E., Kosma, V.M. Tumor cell associated hyaluronan as an
unfavorable prognostic factor in colorectal cancer.
Cancer Res. 58:342-347, 1998.
155
Rowley,J.D. The critical role of chromosome translocations inhuman leukemias.
Annu Rev Genet.32:495-519, 1998.
Ruoslahti, E., Yamaguchi,Y and La ,Jolla. Proteoglycans as modulators of growth
factor activities.
Cancer Research Foundation. 64: 867-869, 1991
Sahab, Z.J., Iczkowski, K.A., Sang, Q.X. Anion exchange fractionation of serum
proteins versus albumin elimination.
Anal Biochem. 368(1):24-32. Epub 2007
Sandra, Z.,Ljiljana ,P,R.,Danilo,V Dušan,V .Human cartilage glycoprotein 39—
biomarker of joint damage in knee osteoarthritis
International Orthopaedics (SICOT). 33:1165–1170, 2009.
Schaider,H., Rech-Weichselbraun,I., Richtig,E., Seidl,H., Soyer,H.P., Smolle,J and
Kerl,H. Circulating adhesion molecules as prognostic factors for cutaneous melanoma
J. Am. Acad. Dermatol.36: 209 - 213, 1997.
Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kundig, T., Wakeham, A.,
Shahinian, A., Catzavelos, C, Rak, J., Furlonger, C, Zakarian, A., Simard, J.J.L., Ohashi,
P.S., Piage, C.J., Gutierrez-Ramos, J.C and Mak, T.W. CD44 regulates hematopoietic
progenitor distribution, granuloma formation, and tumorigenicity.
Blood. 90:2217-2233, 1997.
Seth, R., Raymond, F.D and Makgoba, M.W. Circulating ICAM-1 isoforms:
diagnostic prospects for inflammatory and immune disorders .
Lancet.338:83-84,1991.
Sherman, L., Sleeman, J., Herrlich, P., Ponta, H., Hyaluronate receptors: Key players in
growth, differentiation, migration and tumor progression.
Curr Opin Cell Biol. 6: 726-733, 1994.
Sidransky D. Emerging molecular markers of cancer.
Nature Rev Cancer.2 (3):210–219, 2002.
Sjobring, U. Isolation and molecular characterization of a novel albumin-binding
protein from group G streptococci.
Infect Immun. 60(9): 3601–3608,1992.
Slevin, M., Kumar, S and Gaffney, J. Angiogenic oligosaccharides of hyaluronan
induce multiple signaling pathways affecting vascular endothelial cell mitogenic and
wound healing responses.
J. Biol. Chem. 277: 41046–41059, 2002.
156
Slevin, M., West, D., Kumar ,P., Rooney, P., Kumar ,S. Hyaluronan, angiogenesis
and malignant disease.
Int J Cancer.109:793–794,2004.
Spicer, A.P., and McDonald, J.A.. Eukaryotic hyaluronan synthases. Glycoforum:
science of hyaluronan today.
http://www.glycoforum.gr.jp/science/hyaluronan/HA07/HA07E.html,1998.
Sreeramaneni,R., Chaudhry,A., McMahon,M., Sherr,C.J., Inoue. K. Ras-Raf-Arf
signaling critically depends on the Dmp1 transcription factor.
Mol Cell Biol. 25: 220-232, 2005
Stamenkovic, I., Aruffo, A. Hyaluronic acid receptors.
Methods Enzymol. 245:195-216, 1994.
Steinberg ,W. The clinical utility of the CA 19-9 tumour-associated antigen.
Am J Gastroenterol.85:350–355, 1990.
Stern,R. Hyaluronan catabolism: a new metabolic pathway.
Eur J Cell Biol.83:317–325. 2004.
Stauder, R., Eisterer, W., Thaler, J and Gunthert, U. CD44 variant isoforms in nonHodgkin's lymphoma: A new independent prognostic factor.
Blood .85:2885-2899, 1995.
Sunil, B. K., Hitesh, N. A., Rajeev ,K. B.,Anil ,Thomas, Shib, D. Band M. Karuna
Kumar.Identification of a Novel Hyaluronic Acid Binding Protein inHuman Breast
Cancer Using a Monoclonal Antibody.
Advances in Biological Research 2 (1-2): 06-12, 2008
Suniti, Misra., B, P. Toole., and Shibnath, Ghatak. Hyaluronan Constitutively
Regulates Activation of Multiple Receptor Tyrosine Kinases in Epithelial and
Carcinoma Cells
J. Biol. Chem. 281:34936-34941, 2006.
Sy, M.S., Guom, Y.J and Stamenkovic, I. Distinct effects of two CD44 isoforms on
tumor growth in vivo.
J Exp Med. 174: 859-866, 1991.
Sy, M.S., Guo, Y.J., and Stamenkovic, I. Inhibition of tumor growth in vivo with a
soluble CD44-immunoglobulin fusion protein.
J. Exp. Med. 176: 623–662, 1992.
157
Takahashi, K., Stamenkovic, I., Cutler, M., Saya, H and Tanabe, K.K. CD44
hyaluronate binding influences growth kinetics and tumorigenicity of human colon
carcinoma.
Oncogene. 11: 2223-2232, 1995.
Tammi, M,I., Syrjanen, K.J., Saarikoski ,S.V., Kosma ,V.M. High levels of stromal
hyaluronan predict poor disease outcome in epithelial ovarian cancer.
Cancer Res.60:150–155, 2000.
Tammi, M. I., Day, A. J. and Turley, E. A. Hyaluronan and homeostasis: a balancing
act.
J. Biol. Chem.277: 4581–4584 ,2002.
Tarin,D and Matsumura,Y. Recent advances in the study of tumour invasion and
metastasis.
J.Clin.Pathol.47:385-390,1994.
Tawil,N.J., Gowri,V., Djoneidi, M., Nip, J., Carbonetto ,S and Brodt ,P.
Integrinalpha3beta1 can promote adhesion and spreading of metastatic breast
carcinoma cells on the lymph node stroma.
Int J Cancer.66:703-710, 1996.
Teder, P., William, R. Vandivier, Dianhua Jiang, Jiurong Liang, Lauren Cohn, Ellen
Puré, Peter M. Henson and Paul, W. Noble. Resolution of lung inflammation by
CD44.
Science. 296: 155–158. 2002.
Tchetgen ,M.B., Oesterling ,J.E. The effect of prostatitis, urinary retention,
ejaculation, and ambulation on the serum prostate-specific antigen concentration.
Urol Clin North Am.24:283–291,1997.
Thorne, R. F., Legg, J. W. & Isacke, C. M. The role of the CD44 transmembrane and
cytoplasmic domains in coordinating adhesive and signalling events.
J. Cell Sci. 117:373–380. 2004.
Tirumalai, R.S., Chan ,K.C., DaRue ,A.. Prieto, Haleem, J.. Issaq, Thomas
,P.Conrads., and Timothy .D. Veenstra. Characterization of the low molecular weight
human serum proteome. Mol. Cell. Proteomics. 1:1096-1103,2003.
Toole, B.P., Biswas, C and Gross, J. Hyaluronate and invasiveness of the rabbit V2
carcinoma.
Proc Natl Acad Sci. 76: 6299-6303, 1979.
158
Tool BP. Glycosaminoglycans in morphogenesis. Cell Biology of Extracellular
Matrix. In:
Hay ED, ed. New York: Plenum Press. 259-294,1981.
Toole B.P. Developmental role of hyaluronate.
Connect Tissue. Res.10:93-100, 1982.
Toole, B.P. Hyaluronan and its binding proteins, the hyaladherins.
Curr. Opin. Cell Biol. 2: 839–844. 1990.
Toole,B.P. Proteoglycans and hyaluronan in morphogenesis and differentiation.
Cell Biology of Extracellular Matrix
(Hay, E. D., ed). 305-339, 1991.
Toole, B.P. Hyaluronan, In proteoglycan: Structure, Biology and Molicular
Interactions.
Iozzo, R., ed. marcel Dekker.72: 61-92, 2000.
Toole, B. P. Hyaluronan in morphogenesis.
Semin. Cell. Dev.Biol.12: 79–87, 2001.
Toole, B. P., Wight, T. N and Tammi, M. Hyaluronan–cell interactions in cancer and
vascular disease.
J. Biol. Chem. 277:4593–4596, 2002.
Toole, B.P. Hyaluronan: from extracellular glue to pericellular cue.
Nature reviews cancer. 4:528-539, 2004.
Turley, E, A., Torrance, J. Localization of hyaluronate and hyaluronate-binding
protein on
motile and non-motile fibroblasts.
Exp Cell Res. 161: 17-28 ,1985.
Turley, E.A. Hyaluronan and cell locomotion.
Cancer Metastasis. Rev. 11: 21-30, 1992.
Turley, E. A., Noble, P.W and Bourguignon, L.Y. Signaling properties of hyaluronan
receptors.
J. Biol. Chem. 277:4589–4592, 2002.
Tuxen ,M.K., Soletormos,G., Dombernowsky,P. Tumour markers in the management
of patients with ovarian cancer.
Cancer Treat Rev.21:215–245,1995
159
Uhl-Steidl ,M., Muller-Holzner, E., Zeimet, A.G., Adolf ,G.R., Daxenbichler ,G.,
Marth, C and Dapunt. Prognostic value of CD44 splice variant expression in ovarian
cancer.
Oncology. 52: 400-406, 1995.
Underhill, C.B., Chi-Rosso, G., and Toole, B.P. Effects of detergent solubilization on
the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3
cells.
J. Biol. Chem., 258, 8086–8091,1983.
Underhill, C. CD44, The hyaluronan receptor.
J.Cell Sci. 103: 293-298, 1992.
Velikova, G., Banks, R,E., Gearing, A., Hemingway,I., Forbes,M,A., Preston,S.R., et
al. Serum concentrations of soluble adhesion molecules in patients with colorectal
cancer.
Br J Cancer:77:1857–1863, 1998.
Vogt PK., Gymnopoulos M and Hart JR. PI 3-kinase and cancer: changing accents.
Curr Opin Genet Dev. 19: 12-17, 2009.
Voit, C., Kro, M., Rademaker,J, et al. Molecular staging in stage II and III melanoma
patients and its effect on long-term survival.
JClin Oncol.23:1218-1227, 2005.
Volmer, M. W., Stuhler, K., Zapatka, M., Schoneck, A., Klein-Scory,S., Schmiegel,
W., Meyer, H. E., Schwarte-Waldhoff, I. Differential proteome analysis of
conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer.
Proteomics.5 (10):2587–2601, 2005.
Wang, C., Thor, A. D., Moore, D. H., II, Zhao, Y., Kerschmann, R., Stern, R.,
Watson, P. H and Turley, E. A. The overexpression of RHAMM, a hyaluronanbinding protein that regulates ras signaling, correlates with overexpression of
mitogen-activated protein kinase and is a significant parameter in breast cancer
progression.
Clin. Cancer Res. 4:567-576, 1998.
Watts, N.B. Clinical utility of biochemical markers of bone remodeling.
Clin. Chem. 45:1359-1368, 1999.
Weg-Remers, S., Hildebrandt, U., Feifel, G., Moser, C., Zeitz ,M and Stallmach, A.
Soluble CD44 and Cd44v6 serum levels in patients with colorectal cancer are
independent of tumour stage and tissue expression of CD44v6.
Am JGastroenterol .93: 790–794, 1998.
160
Weigel, P.H., Hascall, V.C., and Tammi, M. Hyaluronan synthases.
J. Biol. Chem.272:13997–14000, 1997.
Weinberg, R. A. How cancer arises.
Sci. Am. 275, 62–70, 1996.
Weng, L. P., Wu, C. C., Hsu, B. L., Chi, L. M.,Liang, Y., Tseng,C. P., Hsieh, L. L.,
Yu, J. S. Secretome-Based Identification of Mac-2 Binding Protein as a Potential Oral
Cancer Marker Involved in Cell Growth and Motility.
J. Proteome Res, 7, 3765–3775, 2008.
West, D.C., Hampson, I. N., Arnold, F and Kumar, S. Angiogenesis Induced by
DegradationProducts of Hyaluronic Acid.Science.
New Series.228: 1324-1326, 1985.
West,D.C, Kumar ,S. Endothelial cell proliferation and diabetic retinopathy.
Lancet. 1:715–716, 1988.
West ,D.C., Kumar S. The effect of hyaluronate and its oligosaccharides on
endothelial cell proliferation and monolayer integrity.
Exp Cell Res.183:179–196,1989.
Whibley,C., Pharoah,P.D., Hollstein, M. p53 polymorphisms: cancer implications.
Nat Rev Cancer. 9; 95-107, 2009.
Wight, T.N and Merrilees., M.J. Proteoglycans in atherosclerosis and restenosis. key
roles for versican.
Circ.Res. 94: 1158–1167, 2004.
Wollenberg,B., Jan,N.V., Sutier,W., Hofmann, K., Schmitt,U.M., Stieber, P. Serum
levels of intercellular adhesion molecule-1 in squamous cell carcinoma of the head
and neck.
Tumor Biol.18:88–94, 1996.
Xing,R.dong., Chang,Shi-min., LI ,Jian-hua., LI ,Hua., Han, Zheng-xue. Serum
hyaluronan levels in oral cancer patients.
Chinese Medical Journal , Vol. 121 No. 4:327-330,, 2008.
Xue, H., Lu, B., Lai, M. The cancer secretome: a reservoir of biomarkers.
J. Transl. Med, 6, 52, 2008.
161
Yang, B., Yang, B.L., Savani, R.C and Turley, E.A., Identification of a common
hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link
protein.
EMBO J. 13: 286-296, 1994.
Yang ,X., Wright,J. A. , Turley,E. A. , and Greenberg,A. H. Soluble hyaluronan
receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1
expression.
JEM vol. 183no. 41663-41668, 1996.
Yoneda, M. key molecules to an understanding of intracellular hyaluronan function.
Connective Tissue.33: 227-233, 2001.
Yu, Q., Toole, B.P., and Stamenkovic, I. Induction of apoptosis of metastatic
mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function.
J. Exp. Med. 186:1985–1996, 1997.
Yu, Q. and Stamenkovic, I. Localization of matrix metalloproteinase 9 to the cell
surface provides a mechanism for CD44-mediated tumor invasion.
Genes Dev. 13:35–48, 1999.
Zahalka, M.A., Okon, E., Gosslar, U., Holzmann, B., and Naor, D. Lymph node (but
not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent.
J. Immunol. 154:5345–5355, 1995.
Zalewski, B., Famulski ,W., Sulkowska,M., Sobaniec-Lotowska,M., Piotrowski,Z.,
Kisielewski,W.,Sulkowski,S.CD44 expression in colorectal cancer. An
immunohistochemical study including correlation with cathepsin D immune reactivity
and some tumour clinicopathological features.
Folia Histochem Cytobiol; 39:152-153, 2001.
Zalewski, B. Levels of v5 and v6 CD44 splice variants in serum of patients with
colorectal cancer are not correlated with pT stage, histopathological grade of
malignancy and clinical features
World J Gastroenterol.10(4):583-585, 2004.
Zeimet, A,G., Widschwendter ,M., Uhl-Steidl ,M., Muller-Holzner, E.,
Daxenbichler,G., Marth, C and Dapunt ,O. High serum levels of soluble CD44 variant
isoform v5 are associated with favourable clinical outcome in ovarian cancer
Br. J. Cancer. 76:1646 - 1651, 1997.
Zeng, C., Toole, B.P., Kinney, S.D., Kuo, J.W., and Stamenkovic, I. Inhibition of
tumor growth in vivo by hyaluronan oligomers.
Int. J. Cancer.77: 396–401, 1998.
162
Zermati Y., Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL,
Rosselli F, D'Amelio M, Amendola R, Castedo M, Hengartner M, Soria JC, Cecconi
F, Kroemer G. Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.
Mol Cell. 28: 624-637, 2007.
Zhang, H., Kelly, G., Zerillo, C., Jaworski, D.M., Hockfield, S. Expression of a
cleaved brain-specific extracellular matrix protein mediates glioma cell invasion in
vivo.
J Neuro Sci .18:2370-2376,1998.
Zhang, J.C., Wang,Z.R., Cheng,Y.J., Yang,D.Z., Shi,J.S., Liang ,A.L., Liu,N.N.,
Wang,X.M. Expression of proliferating cell nuclear antigenand CD44 variant exon 6
in primary tumours and corresponding lymph node metastases of colorectal carcinoma
with Dukes’ stageC or D.
World J Gastroenterol. 9: 1482-1486, 2003.
Zhang, L., Underhill ,C.B., Chen, L. Hyaluronan on the surface of tumor cells is
correlated with metastatic behavior.
Cancer Res. 55: 428-433, 1995.
Zhang,Y.L., Pang,L.Q., Wu,Y., Wang,X.Y., Wang,C.Q., Fan,Y. Significance of BclxL in human colon carcinoma.
World J Gastroenterol.14: 3069-3073, 2008.
Zhu, L., Hope, T.J., Hall, J., Davies, A., Stern, M., Muller-Eberhard, U., Stern, R and
Parslow, T.G. Molecular cloning of a mammalian hyaluronidase reveals identity with
hemopexin, a serum heme-binding protein.
J Biol Chem. 269: 32092-32097, 1994.
Ziegler,J.L and Buonaguro,F.M. Infectious agents and human malignancies.
Front Biosci. 14: 3455-3464, 2009.
Zink, D., Sadoni,N., Stelzer,E. Visualizing chromatin and chromosomes in living
cells.
Methods. 29:42-50, 2003.
163