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This article was downloaded by: [Consorci de Biblioteques Universitaries de Catalunya] On:
This article was downloaded by: [Consorci de Biblioteques Universitaries de Catalunya] On: 27 February 2009 Access details: Access Details: [subscription number 789296668] Publisher Informa Healthcare Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK Scandinavian Journal of Urology and Nephrology Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t713692219 Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it Jukka Sairanen a; Mikael Leppilahti b; Teuvo L. J. Tammela c; Ilkka Paananen d; Sirpa Aaltomaa e; Kimmo Taari a; Mirja Ruutu a a Department of Urology, Helsinki University Hospital, Helsinki, Finland b Division of Urology, Seinäjoki Central Hospital, Seinäjoki, Finland c Department of Surgery/Urology, Tampere University Hospital, and Medical School, Tampere, Finland d Department of Urology, Oulu University Hospital, Oulu, Finland e Department of Urology, Kuopio University Hospital, Kuopio, Finland First Published on: 09 January 2009 To cite this Article Sairanen, Jukka, Leppilahti, Mikael, Tammela, Teuvo L. J., Paananen, Ilkka, Aaltomaa, Sirpa, Taari, Kimmo and Ruutu, Mirja(2009)'Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it',Scandinavian Journal of Urology and Nephrology, To link to this Article: DOI: 10.1080/00365590802671031 URL: http://dx.doi.org/10.1080/00365590802671031 PLEASE SCROLL DOWN FOR ARTICLE Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Scandinavian Journal of Urology and Nephrology 2009, 18, iFirst article ORIGINAL ARTICLE Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it JUKKA SAIRANEN1, MIKAEL LEPPILAHTI2, TEUVO L. J. TAMMELA3, ILKKA PAANANEN4, SIRPA AALTOMAA5, KIMMO TAARI1 & MIRJA RUUTU1 1 Department of Urology, Helsinki University Hospital, Helsinki, Finland, 2Division of Urology, Seinä joki Central Hospital, Seinä joki, Finland, 3Department of Surgery/Urology, Tampere University Hospital, and Medical School, Tampere, Finland, 4 Department of Urology, Oulu University Hospital, Oulu, Finland, 5Department of Urology, Kuopio University Hospital, Kuopio, Finland Abstract Objective. Painful bladder syndrome/interstitial cystitis (PBS/IC) is an inflammatory bladder disease of unknown origin. Symptoms of PBS/IC compromise patients’ quality of life (QoL). This study evaluated a health-related quality of life (HRQoL) questionnaire in PBS/IC. Material and methods. 151 patients with PBS/IC filled in the HRQoL questionnaire before and after the treatment. Of these, 87 patients participated in a 3-month randomized study testing intravesical dimethyl sulfoxide (DMSO) and bacille CalmetteGuérin (BCG) and 64 patients took part in a 6-month randomized study evaluating oral cyclosporine A (CyA) and pentosan polysulfate sodium (PPS). The changes in HRQoL questionnaire were evaluated with respect to the changes in global response assessment (GRA). Results. The results of the HRQoL questionnaire reflected well the post-treatment GRA. Patients responding to their treatment had improved QoL. CyA treatment had more impact on emotional well-being, social functioning, activity limitation days, pain and physical capacity than PPS treatment (pB0.05). More patients responded to DMSO than BCG treatment according to GRA (pB0.01), but the results in HRQoL questionnaire were equal after DMSO and BCG treatments. Conclusions. The HRQoL questionnaire can be used in evaluating QoL in PBS/IC patients. Treatment of PBS/IC had obvious effects on QoL. Introduction Painful bladder syndrome/interstitial cystitis (PBS/ IC) is a debilitating bladder disease of unknown origin. The symptoms include bladder-related pain and urinary frequency in the day-time and nighttime. Treatment options have an unforeseeable effect on the symptoms as the aetiology remains elusive. Dimethyl sulfoxide (DMSO) and pentosan polysulfate sodium (PPS) therapies have shown to be superior to placebo, and the Food and Drug Administration (FDA) has approved only these two treatment options for PBS/IC [13]. Other treatments with reported promising results include intravesical bacille CalmetteGuérin (BCG) and oral cyclosporine A (CyA) [4,5]. Quality of life (QoL) of PBS/IC patients is compromised owing to the chronic state of the disease. It was shown in an Austrian health screening project that the prevalence of PBS/IC-related symptoms affected QoL in women who participated in the survey [6]. It is advisable, when conducting an interventional study on PBS/IC, to include an evaluation of QoL [7]. No specific questionnaire exists for PBS/IC for such studies. A single QoL question appears in some studies [8], and more comprehensive questionnaires like SF-36 have served in some other studies [911]. General questionnaires can evaluate different QoL aspects. Such a questionnaire should be simple enough to be incorporated in an outpatient clinic-based follow-up study. For example, the questions should be relevant Correspondence: J. Sairanen, Urologian klinikka, 1. kerros, PL 340, FI-00029 HUS, Finland. Tel: 35 8504271039. Fax: 35 8947178392. E-mail: jukka. [email protected] (Received 9 July 2008; accepted 8 December 2008) ISSN 0036-5599 print/ISSN 1651-2065 online # 2009 Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS) DOI: 10.1080/00365590802671031 Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 2 J. Sairanen et al. to patients, easy to understand and quick to answer. A comparative trial with four generic QoL instruments showed that none of those could be considered as the gold standard [12]. Authors suggested that researchers should select an instrument sensitive to the health states they are investigating. In 1995, Cleary et al. introduced a questionnaire to measure whether the effect of antiandrogen therapy differs from that of castration on the QoL in patients with prostate carcinoma (PC)[13]. This was tailored to be easy to answer; it covered domains of general health perceptions, pain, emotional wellbeing, vitality, social functioning, physical capacity, sexual interest, sexual functioning, activity limitation and bed disability. The questions in single domains were mainly adapted from QoL questionnaires previously established and validated. This HRQoL questionnaire was further translated and validated in several languages and proved effective in a cohort of 550 patients with PC. As it is also available in Finnish and Swedish, the two official languages in Finland, it was adapted for the present clinical PBS/ IC trials. A common endpoint in intervention studies is global response assessment (GRA) [14]. GRA classifications differ. On a six-point scale one category is for symptom deterioration and one for stable disease, whereas four are for symptom improvement. This study aimed to find out whether the change in HRQoL questionnaire correlates with the GRA. Two prospective, randomized, open-label, intervention studies on PBS/IC were conducted. In the first study, intravesical DMSO was compared with intravesical BCG. In the second study, the clinical effect of oral cyclosporine A (CyA) was compared with pentosan polysulfate sodium (PPS). In these two separate trials the usefulness of the HRQoL questionnaire was assessed by comparing its change with a GRA given by the patient. Further, the study investigated whether intravesical DMSO or BCG and oral CyA or PPS have different impacts on HRQoL. Material and methods Two consecutive clinical studies on the treatment of PBS/IC were carried out as multicentre studies in eight urological units in Finland. The first study comprised 75 patients with PBS/IC recruited from September 1999 to June 2002. The patients were randomized in a 1:1 ratio to six weekly instillations with either 50 ml 50% DMSO or 50 ml Tice strain BCG. The endoscopic appearance of the bladder after the last hydrodistension was similar in the DMSO and BCG groups. In the DMSO group 16 patients had extensive glomerulations, nine had moderate glomerulations and 12 had only light glomerulations. In the BGC group there were 21 extensive glomerulations, eight moderate glomerulations and nine light glomerulations. Five patients in the CyA group and 10 in the PPS group had a Hunner’s ulcer; these numbers do not differ statistically. All patients filled in the HRQoL questionnaire before treatment and in the follow-up at 3 months. They also marked in the follow-up their subjective global assessment of treatment response (GRA). GRA was graded as follows: 1 worse, 2no change, 3 slightly better, 4 moderately better, 5much better, and 6 completely cured. Participants who reported either of the two latter categories were considered treatment responders. At 3 months, if treatment response was not achieved, the patients were allowed to change to another treatment group without any specified washout period. Then a new baseline HRQoL questionnaire and a new outcome questionnaire at 3 months were obtained. The second study randomized 64 patients to either oral CyA (1.5 mg/kg twice a day) or oral PPS (100 mg three times a day). The same questionnaire was filled in by the patients before and after 6 months of treatment. GRA was analysed by the same method as described above. This study started randomizing patients in October 2002 and stopped in March 2004. The clinical results of that study were published in detail [15]. The patients who dropped out from their treatment before the study end were considered non-responders (GRA 1). Inclusion and exclusion criteria for patient selection for both studies depended on the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) criteria for PBS/IC [16]. During the study period, no other specific treatment for PBS/IC was given and the effect of any previous treatment (e.g. hydrodistension) had to have disappeared. No specific time limit was given to wait before starting DMSO, BCG, CyA or PPS treatment after a failed previous therapy. Analgesics or medication for insomnia were still allowed when necessary. The utility of the QoL questionnaire was assessed by comparing it with the subjective GRA. The changes in different categories of QoL were calculated according to treatment group. Quality of life questionnaire A 30-item questionnaire (Appendix) was selected. This previously validated questionnaire was available in Finnish and Swedish. It comprises different fields of QoL: general health perceptions, pain, emotional well-being, vitality, social functioning, Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 Quality of life with painful bladder/interstitial cystitis physical capacity, and both sexual interest and functioning. Questions about disability days and activity limitation days are also included. A question addressing the issue of erectile dysfunction was left out because 89% of the patients were females. Statistical analysis was done with SPSS 13.0. The Wilcoxon rank sum test was used to compare QoL points between different GRA categories. One-way ANOVA was applied to calculate the similarity of baseline characteristics between all treatment arms. Differences in the response rates between the treatments were calculated by Fisher’s exact test. The t test was used in comparison of treatment efficacy in the different domains of QoL. For both studies the sample size was calculated on a specific power analysis which was based on the improvement of clinical symptoms. In the CyA/PPS study a sample size of 64 was selected to detect a difference in response rates of 70% and 35%, and 80% power at a two-sided significance level of 5% was used. Loss of 10% of patients in the follow-up was estimated. In DMSO/BCG study the primary endpoint was alleviation of pain, as a visual analogue scale (VAS) score. A 50% reduction in pain on the VAS was calculated to be seen in 40% of patients in the DMSO group and 65% of patients in the BCG group. Power of 80% at a two-sided significance level of 5% was used. Patient loss in follow-up was estimated to be 20%, which raised the total number of patients needed to 72. All patients gave written informed consent. The study protocols were approved by the ethics committees of all participating hospitals. Results In the first study 37 patients were randomized to DMSO treatment and 38 to BCG treatment. Thirteen patients in the BCG group changed into the DMSO group at 3 months and 12 patients in the DMSO group changed into the BCG group. The total number of treatments with either instillation was 100 (50 in each group). Six patients in the DMSO group and seven in the BCG group dropped out before the 3 month final evaluation, leaving 87 treatments for analysis. In the second study, 29 patients out of 32 in both CyA and PPS groups completed the study, leaving 58 patients for final analysis. The patients’ baseline characteristics and number of responders to treatment are listed in Table I. The patients in the CyA/PPS study had smaller bladder capacities than in the DMSO-BCG study, resulting in more frequent voiding in 24 h. There was a higher response rate after DMSO therapy than after BCG therapy (p B0.01), and CyA therapy had a 3 significantly higher response rate than PPS therapy (p B0.001). In the whole cohort, when only the primary instillation therapy is included, 38 patients (27%) responded to the therapy (GRA 5 or 6), whereas 101 (73%) did not (GRA 14). When the secondary instillation (after group change) was also included, the number of treatment responders increased to 50 (32%) (Table II). Of the 164 HRQoL questionnaires distributed at the beginning, 158 were obtained before treatment (six patients did not return the questionnaire). After treatment 138 questionnaires were evaluated. There were 20 forms missing at follow-up, owing to 19 dropouts during the treatment and one form being lost. The questionnaire was usually answered conscientiously, but the questions concerning sexuality were left unanswered by half of the patients. Sixtyseven patients out of 164 (41%) reported having had sexual activity within the past month. There were no differences in sexual activity between the four treatment groups. Post-treatment GRA correlated with the change in HRQoL questionnaire (Table II). If the patient responded to the treatment (GRA 5 or 6), the HRQoL questionnaire improved significantly in aspects of general health perceptions, pain, emotional well-being, vitality, social functioning and physical capacity. Disability days and activity limitations days were also significantly changed in those patients. The domain of pain was improved also in patients in GRA 4 category. Furthermore, patients with impaired symptoms after treatment (GRA 1) experienced worse HRQoL in social functioning and had more disability days (Table II). HRQoL was statistically similar in all four treatment arms at baseline. DMSO and BCG therapies had an equal effect on HRQoL, but CyA therapy resulted in significant changes in HRQoL compared with PPS. The results are shown in Figure 1. Discussion This study showed a correlation between GRA and a common HRQoL questionnaire. The results indicate that patients having either GRA 5 or 6 (much improved or cured) after treatment also have improved QoL. They are the true treatment responders. No previous reports testing the effect of intravesical DMSO, oral PPS or CyA therapy on QoL in patients with PBS/IC exist to be used as a reference or comparison to the present study. In this study the response rate was higher after CyA therapy than after PPS therapy. CyA also had a significant impact on the HRQoL questionnaire. The superiority of CyA to PPS in the HRQoL 4 J. Sairanen et al. Table I. Baseline characteristics of the patients and the response rates in the treatment groups. Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 Female/male Age of the patients Duration of symptoms (years) Frequency in 24 h Nocturia episodes Mean voided volume (ml) VAS (cm) No. of treatment responders (%) (GRA 5 or 6) DMSO (n37) BCG (n38) CyA (n 32) PPS (n 32) Total (n 139) Difference between all study arms (one-way ANOVA) 37/0 61.4911.3 11.3910.1 14.295.7 4.092.5 147958 6.492.1 11 (30%) 34/4 57.9914.7 8.598.5 14.296.1 4.192.6 140963 6.892.1 4 (11%) 27/5 56.2914.7 7.897.0 16.794.4 3.992.2 122939 6.892.0 19 (59%) 26/6 59.7913.3 8.996.7 19.198.4 4.293.3 106946 7.092.1 4 (13%) 124/15 59.2913.0 9.798.7 15.596.17 4.092.6 136958 6.792.0 38 (27%) NS NS NS p 0.002 NS p 0.002 NS + Data are shown as mean9SD. Baseline characteristics compared between dimethyl sulfoxide (DMSO) and bacille CalmetteGuérin (BCG) groups or between cyclosporine A (CyA) and pentosan polysulfate sodium (PPS) groups were similar. VASvisual analogue scale; GRAglobal response assessment; NS not significant. *The response rate was higher in the DMSO group than in the BCG group (p B0.05) and in the CyA group than in the PPS group (p B0.001) (Fisher’s exact test). questionnaire is in accord with a previous report of its clinical effects on PBS/IC-related symptoms [15]. Both BCG and DMSO treatments had a similar impact on the HRQoL questionnaire. However, it is not possible to compare the HRQoL results directly between the two study groups (DMSO/BCG versus CyA/PPS) because these were two independent studies with different treatment protocols. Although the inclusion and exclusion criteria were similar in both protocols the patients had smaller mean voided volumes and higher frequency in 24 h in the CyA/ PPS study. There were no differences between the groups regarding patients’ age, gender distribution, mean symptomatic time before the studies, VAS score for pain or numbers of nocturia episodes. Most important was that there were no differences in any aspects of baseline results in the HRQoL questionnaire, making it possible to use that as an endpoint. In that respect, it is suitable to report the changes in HRQoL in different GRA categories of the whole cohort, but head-to-head comparison of treatment effect with voiding symptoms or symptom scores is Table II. Results of the health-related quality of life questionnaires after treatment with any of the four therapies according to the global response assessment (GRA) (1worse, 2no change, 3 slightly better, 4moderately better, 5much better, 6 completely cured). Measure Baseline (n158) GRA 1 (n11) GRA 2 (n 27) GRA 3 (n27) GRA 4 (n 23) GRA 5 (n34) GRA 6 (n 16) General health perceptions (010) 5.291.9 4.291.9 5.092.6 5.391.9 5.792.0 Pain (110) 5.491.8 6.192.2 5.992.2 4.092.2 Emotional well-being (0100) 62.0918.0 50.4914.4 59.7917.1 62.5915.1 3.791.4 p 0.007* 72.7914.7 Vitality (0100) 55.0916.7 48.5912.8 55.3918.0 55.5916.0 65.1917.7 Social functioning (16) 3.291.3 3.391.5 3.791.4 4.091.5 Physical capacity (1 best5 worst) 2.190.7 2.191.2 p0.03$ 2.791.0 2.090.9 1.990.9 1.790.7 7.392.2 p 0.011* 1.891.5 p 0.002* 81.5913.5 p 0.026* 75.1914.1 p 0.029* 5.491.0 p 0.002* 1.691.0 Sexual interest (15) Sexual functioning (15) Disability days (07) 1.790.8 2.591.3 1.191.7 1.790.8 3.191.6 1.291.4 1.990.8 2.090.7 0.490.9 1.790.9 2.791.3 0.591.0 Activity limitation days (07) 3.392.2 3.392.1 2.592.5 2.291.9 6.792.1 p0.001* 2.591.4 p0.001* 79.8916.2 p 0.01* 68.1914.9 p0.014* 5.091.1 p0.001* 1.490.5 p0.002* 1.890.8 2.791.1 0.290.6 p0.035* 1.091.4 p0.001* 1.590.7 3.391.6 2.191.9 p 0.026$ 4.392.0 2.191.1 1.690.7 0.691.8 0.390.7 p 0.01* Data are shown as mean9SD. Patients having a secondary treatment with either dimethyl sulfoxide (DMSO) or bacille CalmetteGuérin (BCG) are included. $ Significant difference compared with baseline towards impairment; *significant difference compared with baseline towards improvement. Wilcoxon Rank Sum test used in all measurements. DMSO BCG CYA PPS BCG CYA PPS 5.8±1.6 4.9±2.3 2.9±2.1 5.5±1.7 5.31.9 4.2±2.5 3.1±1.3 3.4±1.4 5.0±1.3 3.3±1.1 3.8±1.6 1.1±1.7 CYA PPS CYA 0.8±1.5 0.5±0.8 0.5±1.1 1.2±1.3 0.9±1.5 BCG PPS BCG CYA PPS DMSO BCG CYA 16 (50%) 16 (55%) 15 (52%) 11 (34%) 2.7±1.4 2.9±1.3 2.3±1.2 2.7±1.0 2.4±1.2 2.5±1.5 2.7±1.4 DMSO 18 (42%) (k) 2.0±1.0 1.6±0.6 1.8±0.8 2.0±1.0 2.2±1.0 1.7±0.9 1.7±0.9 1.6±0.8 1.6±0.8 DMSO 5.2±1.9 DMSO (j) (i) BCG 0.7±1.5 0.8±1.5 0.5±0.8 1.2±1.3 0.5±1.1 1.1±1.7 0.9±1.5 1.3±1.9 PPS PPS (h) 0.7±1.5 1.9±0.7 1.7±0.7 2.2±0.5 CYA DMSO 22 (44%) BCG 1.5±0.7 2.0±1.1 2.1±0.8 2.1±0.8 DMSO 4.2±1.6 53.8±16 PPS 1.3±1.9 CYA 60±16 63.9±16 50.3±12 58.0±21 65.2±16 56.7±19 BCG (g) 1.8±0.8 (f) DMSO 19 (43%) PPS CYA (e) 57.0±17 65.4±15 58.8±18 58.5±13 CYA BCG 18 (36%) BCG 75.9±15 65.5±20 65.4±21 70.6±18 DMSO DMSO 3.2±1.3 5.4±1.9 PPS 3.2±1.5 CYA 5.9±2.0 5.2±1.7 6.4±2.2 5.2±2.0 BCG (d) 63.70±19 (c) 5.4±2.7 5.2±1.9 5.9±2.2 DMSO 3.1±2.0 (b) (a) PPS Figure 1. Results of the HRQoL questionnaire after four treatments: dimethyl sulfoxide (DMSO), bacille CalmetteGuérin (BCG), cyclosporine A (CyA) and pentosan polysulfate sodium (PPS). The patients receiving DMSO or BCG as a secondary instillation are also included. Results are presented as mean9SD. Baseline results in the HRQoL questionnaire were comparable between all groups (one-way ANOVA). Number of patients included: DMSO 50 pretreatment and 44 post-treatment, BCG 50 pretreatment and 43 post-treatment, CYA 32 pretreatment and 29 posttreatment, PPS 32 pretreatment and 29 post-treatment. Black bars pretreatment values; white bars post-treatment values. (a) general health perceptions 010; (b) pain 110; (c) emotional wellbeing 0100; (d) vitality 0100; (e) social functioning 16; (f) physical capacity 15 (1 best, 5 worst); (g) disability days 07; (h) activity limitation days 07; (i) sexual interest 15 (1 best, 5 worst); (j) sexual functioning 15 (1 best, 5 worst); (k) number of patients (%) having sex (masturbation or intercourse). The effect of DMSO and BCG treatments on all aspects of the HRQoL did not differ from each other. The effect of CyA was greater than that of PPS on aspects of pain, emotional well-being, social functioning, physical capacity and activity limitation days (pB0.05; t test). Quality of life with painful bladder/interstitial cystitis Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 . 5 Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 6 J. Sairanen et al. possible only between DMSO and BCG, and between CyA and PPS. The treatments were not blinded in the CYA/PPS study because of the safety measurements in the CyA group and the different daily dosing intervals of the drugs. In the DMSO/ BCG study the patients were allowed to switch the treatment arms if they had no response to their treatment. The HRQoL questionnaire implemented in this study has never been used in PBS/IC before. It has been used in studies with prostate cancer under hormonal treatment [13,17,18]. The authors think that it is comparable to any other standard validated HRQoL questionnaire. Boccardo et al. [17] adopted the questionnaire for the follow-up of patients with bicalutamide monotherapy or total androgen blockade in the treatment of PC, but did not use the original method of calculating the points in different domains. The present study followed the original method of reading the results [13]. The prognosis of PBS/IC and PC is different and the gender distribution between the participants (93% of this PBS/IC cohort being female) was almost opposite. Head-to-head comparison of the results in the HRQoL questionnaire between PBS/ IC and PC is impossible. Still, some comparison can be made between these results and those of Clearly et al. [13], to recognize the impact of PBS/IC on QoL. The pain differed a lot between these populations, as PBS/IC patients had more pain than PC patients. In the Cleary study [13], the pain index (mean9SD) was 3.292.1 for the 487 PC patients under hormonal therapy, while it was 5.491.8 for the present 139 patients before starting the therapies. The pain index for the present cohort reduced to a mean of 3.892.3 after the therapies, which was still higher than that of patients with PC under hormonal therapy. These results can be considered as expected as PBS/IC is a syndrome with the most important symptom being pain [19,20]. Other impaired domains in PBS/IC patients were emotional well-being, social functioning and general health perceptions compared with PC patients in the study by Cleary et al. The HRQoL questionnaire used here was practical, easy to fill in and well received by the patients. The questions on sexuality were an exception, with a low response rate. This may be explained by the low sexual activity in the cohort and by the domain not being seen as important. The measures of sexual interest and functioning also worked poorly in the development procedure of this questionnaire [13]. The questions considering sexuality should be revised and asked separately, when that domain is of particular interest. In patients younger than these (mean age 59.2 years in this cohort) sexuality is an important issue. In this study only 40% of patients were sexually active. In a previous study, sexual function was proposed to be an important predictor of physical QoL [21]. However, that study also suffered, probably because of embarrassment, from lacking answers considering sexuality. Forty-nine per cent of women with PBS/IC reported difficulties in sexual intercourse due to exacerbation of their bladder symptoms [22], and fear of provoking the PBS/IC symptoms by sexual intercourse is reported to be significant [23]. In the present study, sexual activity did not increase in patients having a good treatment response. That may be due to neglecting the questions concerning sexuality, or it may reflect permanent low sexual activity among the cohort. After successful therapy, assessed subjectively, the QoL is improved. The sensitivity of the HRQoL questionnaire to identify treatment failures was interesting. Social functioning (p 0.03) and disability days (p 0.026) showed significant impairment in patients in GRA 1 category, in whom the symptoms became worse after treatment. The ability of a questionnaire to detect negative changes in QoL makes it a more reliable tool. Of the treatments in this study, only the effects of BCG therapy on QoL have been reported previously. In a cohort with eight patients, QoL (assessed by the Rand-36 questionnaire) improved after open-label BCG therapy by a mean of 64% [24]. This remarkable change may be explained by the reported results that all patients were treatment responders to BCG. In a placebo-controlled trial BCG had more positive impact on social function and fatigue than placebo, but not on any other Rand-36 domain [4]. In the latest clinical studies the effect of BCG therapy on PBS/IC has been somewhat disappointing, arguing against its the routine use [25]. Despite the HRQoL questionnaire used in this study proving effective in showing differences in treatment outcome in both improved and impaired GRA categories, the development of a questionnaire with additional questions regarding PBS/IC-related problems is still needed. Women and men could even have their own questionnaires as gender has a recognizable impact on the coping strategies to different diseases and on the outcome of treatments [2628]. In the future, a validated questionnaire should be internationally available for large-scale prospective studies. In Europe, the designing of such a questionnaire is possible, as the active European Society for the Study of IC/PBS (ESSIC) has demonstrated its productivity by proposing new diagnostic criteria and nomenclature on PBS/IC [29]. In conclusion, treatment response following therapy for PBS/IC-related symptoms also improves 7 Quality of life with painful bladder/interstitial cystitis Downloaded By: [Consorci de Biblioteques Universitaries de Catalunya] At: 10:07 27 February 2009 QoL aspects. The HRQoL questionnaire used in this study worked well in PBS/IC, even though it was not specially designed for this condition. However, the questions concerning sexuality should be revised. CyA therapy had more impact on the majority of the domains of QoL than PPS therapy. Despite DMSO therapy being more successful than BCG therapy in the number of treatment responders, DMSO and BCG therapies had an equal effect on the HRQoL questionnaire. [12] Hawthorne G, Richardson J, Day NA. A comparison of the assessment of quality of life (AQoL) with four other generic utility instruments. Ann Med 2001;33:35870. [13] Cleary PD, Morrissey G, Oster G. 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Summary of health-related quality of life questionnaire 1. Your initials 2. In which hospital are you being seen? 3. Today’s date 4. How much pain you have had on average since yesterday? (110: 1no pain; 10the worst pain you can imagine) 5. Which number best describes your worst pain during the past 7 days? (110: 1no pain; 10the worst pain you can imagine) 6. Which number best describes your least pain during the past 7 days? (110: 1no pain; 10the worst pain you can imagine) 7. How much did your pain interfere with your activities during the past 7 days? (110: 1not at all; 10extremely) 8. How much of the time, during the past month, has your health limited your ability to visit with close friends or relatives? (16: 1all of the time; 6none of the time) 9. How much of the time, during the past month, has your health limited your ability to participate in other social activities? (16: 1all of the time; 6 none of the time) 10. How much of the time, during the past month, have you been a very nervous person? (16: 1all of the time; 6none of the time) 11. During the past month, how much of the time have you felt calm and peaceful? (16: 1all of the time; 6 none of the time) 12. How much of the time, during the past month, have you felt downhearted and blue? (16: 1all of the time; 6 none of the time) 13. During the past month, how much of the time have you been a happy person? (16: 1all of the time; 6 none of the time) 14. How often, during the past month, have you felt so down in the dumps that nothing could cheer you up? (16: 1all of the time; 6 none of the time) 15. How often, during the past month, did you feel dull or sluggish? (16: 1 all of the time; 6none of the time) 16. During the past month, did you have or feel energy, pep or vitality? (16: 1 all of the time; 6none of the time) 17. How often, during the past month, have you felt tired, worn out, used up or exhausted? (16: 1all of the time; 6 none of the time) 18. For how many days during the past 7 days did you cut down on the things that you usually do because of your health? (17) 19. For how many days during the past 7 days did you stay in bed for all or most of the day because of your health? (17) 20. Which number best describes your overall health during the past month? (110) 21. How much difficulty have you had because of your health during the past month doing vigorous activities, like lifting heavy objects, running or participating in sports? (15: 1 no difficulty; 5unable to do) 22. How much difficulty have you had because of your health during the past month doing moderate activities, like moving a table, carrying shopping or bowling? (15: 1 no difficulty; 5unable to do) 23. How much difficulty have you had because of your health during the past month walking uphill or climbing a few flights of stairs? (15: 1 no difficulty; 5 unable to do) 24. How much difficulty have you had because of your health during the past month bending, lifting or stooping? (15: 1 no difficulty; 5 unable to do) 25. How much difficulty have you had because of your health during the past month going for a short walk outdoors? (15: 1no difficulty; 5unable to do) 26. How much difficulty have you had because of your health during the past month shaving, dressing, bathing or showering? (15: 1 no difficulty; 5unable to do) 27. How much did the following statement apply to you during the past month: ‘‘I was interested in having sex’’? (15: 1 not at all; 5a great deal) 28. How much did the following statement apply to you during the past month: ‘‘ I thought others found me sexually attractive’’? (15: 1 not at all; 5 a great deal) 29. How much did the following statement apply to you during the past month: ‘‘I felt sexually attractive’’? (15: 1not at all; 5a great deal) 30. Have you tried engage in any type of sexual activity, including masturbation or intercourse, during the past month? (1 Yes; 2No) 31. How much did the following statement apply to you during the past month: ‘‘I had difficulty becoming sexually aroused’’? (15: 1 not at all; 5 a great deal) 33. How much did the following statement apply to you during the past month: ‘‘I had difficulty reaching orgasm’’? (15: 1not at all; 5 a great deal)