An Approach to Preschool Wheezing: To Label As Asthma? R

REVIEWS
An Approach to Preschool Wheezing: To Label As Asthma?
Hugo P. Van Bever, MD, PhD, Eugene Han, MD, Lynette Shek, MD, Seo Yi Chng, MD,
and Daniel Goh, MD
Abstract: Asthma is considered a chronic disease, but not all
preschool wheezing is asthma since most will eventually grow out of
their symptoms. Although still a matter of debate, preschool wheezing can be classified in 2 major groups: virus-induced wheezing and
multitrigger wheezing, having a different prognosis and a different
treatment approach. Virus-induced wheezing is the most common
phenotype of preschool wheezing and is usually associated with a
good prognosis. Treatment should be conservative, but if preventive
treatment is required, leukotriene-receptor antagonists might be the
first choice treatment. Multitrigger wheezing is associated with an
allergic disposition and has a higher risk of persistent symptoms.
Inhaled corticosteroids may give short-term reduction in exacerbations, but the beneficial effect of long-term use of inhaled corticosteroids and other anti-inflammatory agents have not yet been
established. This review aims to give an opinion on preschool
wheezing, and its association with asthma.
(WAO Journal 2010; 3:253–257)
INTRODUCTION
D
iagnosing asthma in preschool children is not always
straightforward; it can be confusing or even impossible,
especially when trying to demonstrate chronic airway inflammation. There is increasing awareness that recurrent preschool wheezing exists in several phenotypes that have different prognoses and management strategies. With its
temporal nature, obvious relation to viral illnesses and lack of
data on an underlying inflammatory process, recurrent preschool wheezing should not be synonymous with asthma.
From the few studies that used bronchial biopsies or
bronchoalveolar lavage, it is clear that the inflammatory
reactions in preschool children differ from those in older
children with established asthma.1 However, these studies
were performed in those with severe wheezing or with
unusual clinical features, which limits the value of the
findings. The degrees of inflammation and compositions of
the infiltrates were variable, with neutrophils dominating
From the Department of Pediatrics, YLL School of Medicine, National
University, Singapore.
Correspondence to: Prof. Hugo Van Bever, Department of Paediatrics,
NUS–YLL School of Medicine, NUHS Tower Block, Level 12, 1E Kent
Ridge Road, Singapore 119228. Telephone: 65-6772 4420. Fax: 65-6779
7486. E-mail: [email protected].
Copyright © 2010 by World Allergy Organization
WAO Journal ●
November 2010
in some studies, eosinophils in others and no evidence of
either in the rest.2
The symptoms and signs of asthma in young children
are commonly mimicked by a range of recurrent lower airway
infections, such as bronchitis, bronchiolitis, and pneumonia.
Thus, given the multifactorial nature of all wheezing disorders it is highly likely that a large number of clinical phenotypes exist, and that those phenotypes described in the literature are mainly the extremes of a broad spectrum of
preschool wheezing disorders.3
DEFINITION OF ASTHMA AND
PRESCHOOL WHEEZING
Asthma is one of the most common chronic diseases of
childhood, and is defined as a chronic inflammatory disease
of the lower airways, leading to symptoms of recurrent
wheezing and cough. Because a clear distinction between
asthma and normality has never been established, many
children may have clinical manifestations that are caught in
the “gray zone.” Examples of this are a child with 2 wheezing
episodes within the last 3 months and a child with a prolonged cough for 2 weeks. Although both children cannot be
labeled as normal stricto sensu, they also lack the full features
of asthma.
Hence, asthma should be considered a syndrome, made
up of different phenotypes and occurring at all ages, with
symptoms that can start during infancy or childhood and can
persist up to adulthood.4 Although most definitions of asthma
do not state the duration of the disease or number of exacerbations before the diagnosis is considered, it is generally
accepted that the symptoms should last at least 6 months with
at least 3 exacerbations experienced. A conscious effort must
also be made to exclude other pulmonary diseases like bronchiectasis, structural airway disease and chronic lung disease.
The fact that most recurrent preschool wheezing does
not show the chronicity that is expected in asthma indicates
these children should not be considered the same entity.
Instead, it makes more sense that the diagnosis of asthma is
based on the prediction of the persistence of symptoms in
these children. A recent task force from the European Respiratory Society (ERS) proposed a new classification of preschool wheezing that would guide management and prognostication.5 The classification is certainly useful. However, not
everybody agrees with the new classification and the discussion is still wide open, suggesting more research on the
subject is needed.
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Van Bever et al
DIAGNOSING WHEEZING IN
YOUNG CHILDREN
Wheezing is a symptom that is not always easily
recognized. Other forms of noisy breathing, such as snoring
or even any type of noisy breathing (“ruttles”), are often
labeled as wheezing. Most parents describe wheezing as “any
sound” or “difficult breathing” and there was less than 50%
agreement between parents’ and clinicians’ reports of wheeze
and asthma.6 In another study, parents of 92 infants with
noisy breathing were interviewed, beginning with an open
questionnaire and then directed toward a more detailed description. Wheeze was the most commonly chosen word on
initial questioning (59%). However, only 36% of them were
still using this term at the end of the interview, representing
a decrease of one third, whereas the use of the word ruttles
doubled.7 These studies reflect the degree of inaccuracy
involved in the use of the term wheeze in clinical practice that
may lead to over-diagnosis. This has potentially important
implications in the assessment, management, and research in
preschool wheezing.
PHENOTYPES OF PRESCHOOL WHEEZING
Despite the inaccuracies in diagnosis, wheezing is generally accepted to be a common symptom in young children.
In studies on Singaporean youngsters, it was found that 25%
had wheezing before the age of 2 years.8 Similar results were
found in other studies, notably the Tucson Children’s Respiratory Study where the prevalence of preschool wheezing in
a cohort of 1,246 subjects was more than 30%.9 In different
population studies it was found that approximately 1 in 3
children has at least one episode of wheezing before their
third birthday, and that the cumulative prevalence of wheeze
is almost 50% at the age of 6 years.10 Even with its high
prevalence, there is still a lack of evidence regarding the
pathophysiology and treatment of preschool wheezing. Preschool wheezing is a heterogeneous disease in which 2 major
phenotypes can be distinguished: virus-induced wheezing and
multitrigger wheezing.
Virus-induced wheezing, which accounts for around
two-thirds of all preschool wheezing, is an intermittent form
of recurrent airway obstruction with normal premorbid lung
function and subjects are asymptomatic between episodes. As
these children have a favorable prognosis, they only need
supportive treatment. However, severe attacks induced by
respiratory syncytial virus (RSV) and clinically diagnosed as
bronchiolitis, can be associated subsequently with an increased risk of recurrent wheezing and allergic reactions
during early childhood.11 More recently, human metapneumovirus (HMPV) has been identified as a new respiratory
virus that can induce wheezing and lower respiratory tract
infections in otherwise healthy young children (mean age
11.6 months).12,13 Long-term effects of HMPV and its impact
on severity and persistence of asthma need to be established.
Furthermore, the role of rhinoviruses as a trigger of wheezing
in early life, and as a predictor of asthma at the age of 6 years,
became clear from recent studies, showing that rhinoviruses
are the most common trigger of acute wheezing at all ages.14
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WAO Journal • November 2010
Multitrigger wheezing is usually associated with allergy and is less prevalent in early life, manifesting during the
school-going years. There is usually a family history of
asthma and allergies. This form of wheezing tends to occur
during and between episodes and is more likely to persist
beyond early childhood, with associated significant deficits in
lung growth up to 11 years of age.15
The recent ERS task force proposed following after
approach to preschool wheezing5:
1. For clinical purposes, preschool wheezing should be described in terms of its temporal pattern and classified as
episodic (virus-induced) or multitrigger wheezing.
2. The use of the terms transient, late-onset and persistent
wheeze should probably be limited to population-based
cohort studies and should not be used clinically.
3. The term “asthma” should probably not be used in preschool children because data regarding underlying inflammation are lacking.
However, in real life, it can happen that a specific diagnosis
(viral-induced vs multitrigger wheeze) cannot be made, and
has to be delayed for a period of time until the clinical course
of the recurrent wheezing becomes obvious (ie, transient vs
persistent).
ATOPY AND OTHER RISK FACTORS
Atopy has been associated with persistence of asthmatic symptoms beyond preschool age and seems to be the
major risk factor for an unfavorable prognosis. In the MAS
study, a large cohort study performed in Germany, it was
demonstrated that any allergic sensitization early in life
increases significantly the risk of becoming asthmatic at an
older age.16 Therefore, it has been suggested that prevention
of asthma should be focused on the prevention of allergic
sensitization early in life.
At the moment, a lot of discussion is still ongoing
regarding the role of early exposure to allergens and the
subsequent risk of sensitization. For house dust mite and
pollen, it is generally accepted that an increased exposure
early in life increases the risk for subsequent sensitization and
subsequent allergic disease. In contrast, a study from
Manchester demonstrated that low house dust mite exposure early in life, increases the risk for subsequent sensitization to house dust mite at the age of 3 years.17 The role
of early exposure to pets is also controversial, as more and
more data are showing that early pet exposure induces
tolerance, instead of sensitization, especially in children
from allergic families and especially in those exposed to
dogs.18 –20 Besides allergy, other risk factors for the persistence of asthmatic symptoms beyond preschool age are
male sex and severe RSV bronchiolitis.4
DIAGNOSTIC APPROACH TO
PRESCHOOL WHEEZING
History taking is a main diagnostic tool in preschool
wheezing. The focus should be on confirming the presence of
wheeze (as opposed to other types of noisy breathing), iden© 2010 World Allergy Organization
WAO Journal • November 2010
tifying its temporal pattern, assessing its severity, and identifying possible triggers.
Physical examination can be completely normal, or
may reveal abnormal chest findings (hyperinflation, decreased air entry, wheeze). Signs of an underlying allergic
constitution (rhinitis, conjunctivitis, eczema) may be present.
It is also important to identify unusual or atypical clinical
features that would suggest other underlying chronic pulmonary diseases.
Because there is an increased prevalence of allergy in
preschool wheezing (around 30%), compared with healthy
preschoolers (12%),21 determination of an allergic disposition
via skin prick testing is indicated in the assessment of
preschool wheezing. This is especially so in those with
underlying allergic constitution or family history of allergies.
The Tucson group proposed an asthma index, based on
family history and atopic features, to predict persistence of
asthma.22 By using that index, they were able to show that
95% of preschool wheezing with a negative index did not
develop asthma between the ages of 6 –13 years. In other
studies, the presence of food allergy, especially to hen’s egg,
during the first 3 years of life was a risk factor for the
persistence of asthma until school-going age.
Apart from skin prick testing, other investigations like
viral isolation, radiologic imaging, pH probe studies (to
detect gastroesophageal reflux) and measurement of fraction
of exhaled nitric oxide have limited value in the work-up of
preschool wheezing.5 Spirometry is difficult to perform in
young children, but impulse oscillometry is an emerging,
noninvasive and accurate means of assessing lung function in
children as young as 3 years of age.23
The recent ERS task force recommends the following
approach to the assessment of preschool wheezing5:
1. The pattern and triggers of wheeze, personal and family
history of allergies, and household smoking should be
assessed by history taking.
2. Wheezing reported by parents should be verified by a
healthcare professional.
3. Allergy testing should be performed in children requiring
long-term management.
4. Other investigations should be avoided unless the wheezing is unusually severe, therapy-resistant or accompanied
by unusual clinical features.
PHARMACOLOGICAL THERAPY
Apart from environmental control, allergen avoidance
and parent education, pharmacological treatment should be
focused on prevention of symptoms and on improving the
long-term outcome of preschool wheezing.
Acute Therapy
Acute symptoms are commonly treated with shortacting beta-agonists, systemic corticosteroids (prednisolone)
and oxygen in severe cases. Oral prednisolone has not been
shown to be useful in mild-moderate wheezing associated
with viral infections.24 The role of ipratropium bromide is
less clear, although minimal additional effect to short-acting
beta-agonists has been reported, especially in infants.25 The© 2010 World Allergy Organization
An Approach to Preschool Wheezing
ophylline is not longer recommended because of its potential
side effects and its minimal bronchodilating effects.26 Intravenous or inhaled magnesium sulfate has been insufficiently
studied in preschool children, but from the available literature, it seems that intravenous magnesium sulfate is more
effective than inhaled magnesium sulfate in older children
with acute asthma.27
Preventive Therapy
Inhaled corticosteroids (ICS)
Most children with preschool wheezing will grow out
of their symptoms and do not need any preventive treatment;
especially when the symptoms are mild or infrequent. However, when symptoms are severe or frequent, the initiation of
a preventive treatment will decrease symptoms and improve
quality of life of the child and the family. Furthermore, by
suppressing bronchial inflammation, the risk for basal membrane thickening, permanent bronchial damage and impaired
lung growth may theoretically be reduced. However, it was
never shown that preventive treatment with ICS is able to
decrease the occurrence of persistent childhood or adult
asthma.28
The short-term effectiveness of ICS in young asthmatic
children has been shown, including the reduction of symptoms, improvement of lung function, and suppression of
bronchial hyperreactivity.29 In general, it appears that ICS are
more effective in multitrigger wheezing than in virus-induced
wheezing, as a number of negative studies in virus-induced
wheezing were published.30 –32 However, good comparative
studies on the effect of ICS in different phenotypes of
wheezing are still lacking.
However, recent studies were unable to demonstrate
significant long-term effects or disease modifying effects of
ICS in young asthmatic children. In a study on 285 young
children with a high risk for persistent asthma, inhaled fluticasone (88 ␮g twice daily) for 2 years was unable to change
the development of asthma symptoms or lung function abnormalities during a third, treatment-free year. These findings
do not support any disease-modifying effect of ICS after the
treatment is discontinued.28 This was also seen in older
asthmatic children, where asthma symptoms recur when ICS
is discontinued.33 In another study on 411 wheezing infants,
intermittent budesonide had no effect on the progression from
episodic to persistent wheezing and no short-term benefit
during episodes of wheezing in the first 3 years of life.34 In
yet another study on 129 preschool children with moderatesevere virus-induced wheezing, preemptive treatment with
high-dose inhaled fluticasone reduced the use of rescue oral
corticosteroids. However, this was at the price of decreased
height and weight gain.35
Taken together, it seems that ICS have a limited longterm effectiveness in young children with recurrent wheezing. Short-term effectiveness of ICS has been shown, but a
clear disease-modifying effect was never demonstrated.
Leukotriene-Receptor
Antagonists (Montelukast)
Effectiveness of montelukast in preventing both virusinduced and multitrigger wheezing has been shown in a
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WAO Journal • November 2010
Van Bever et al
number of studies.5 However, there are also studies that show
no improvement, such as a recent multicenter study on the
protective effect of montelukast on postbronchiolitis wheezing.36 From comparative studies between montelukast and
ICS published, it was concluded that the clinical effect of
montelukast is comparable to that of a low dose ICS, and that
montelukast might be more indicated to prevent virus-induced wheeze, while ICS should be used in cases of multitrigger wheeze.37,38
A latest study in 2009 showed that preschool children
with moderate-severe intermittent wheezing did not have
increased episode-free days or decreased corticosteroid use
with episodic use of either budesonide or montelukast in early
respiratory infections. However, that study did show decreased severity of acute illness in children with positive
asthma predictive indices.39
Long Acting Beta-Agonists (LABA)
Although it has been shown that LABAs have a bronchodilating effect in young children,40 there are no studies on
long-term efficacy or safety of LABAs, with or without
inhaled corticosteroids, in young asthmatic children. Therefore, the usage of LABAs is not recommended in preschool
children. In older children (6 to 17 years of age), a recent
study of Lemanske et al was able to show that adding a
LABA is the best way to go if asthma is uncontrolled with a
low dose of ICS.41
CONCLUSION
If asthma is considered a chronic disease, then not all
preschool wheezing is asthma because most will eventually
grow out of their symptoms. Although still a matter of debate,
it makes sense to classify preschool wheezing according to its
long-term prognosis, as a distinction between virus-induced
and multitrigger wheezing (ie, allergic wheezing) might better guide treatment and prognostication.
Virus-induced wheezing is the most common phenotype of preschool wheezing and is usually associated with a
good prognosis. Treatment should be conservative, but if
preventive treatment is required, leukotriene-receptor antagonists might be first choice. ICS also might be tried out in
these kids. Multitrigger wheezing is associated with an allergic disposition and has a higher risk of persistent symptoms.
It has been shown that ICS may give short-term reduction and
prevention of exacerbations, but the beneficial effect of longterm use of ICS and other anti-inflammatory agents have not
yet been established. Furthermore, a comparative study between the 2 wheezing groups on the effectiveness of ICS has
never been published. Therefore, further studies should attempt to determine if continuous long-term administration of
any preventive treatment is able to improve the long-term
outcome of any type of preschool wheezing.
A practical approach could be the after:
In a preschooler with recurrent wheezing, the possibility of an underlying allergy should be assessed (by skin prick
testing or determination of specific IgE).
If allergy is not present, the wheezing should be considered as nonallergic (ie, viral-induced wheezing), and usually little maintenance treatment is needed, as most of the
256
children will grow out of it. Therefore, treatment should be
focused on treating the symptoms (with beta-agonists, short
coursed of prednisolone, etc). If the symptoms seem frequently a leukotriene-receptor antagonist might be considered in the first place, before starting ICS.
In contrast, if allergy is present (positive skin prick test
or positive specific IgE) there is an increased risk that the
child will continue wheezing beyond preschool age. In this
case ICS might be necessary to control the underlying inflammation and to prevent symptoms. However, it has not
been shown that ICS will prevent the progress toward childhood asthma beyond preschool age.
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